Seyyed Shamsadin Athari

Zanjan University of Medical Sciences Iran

Dr. Seyyed Shamsadin Athari is an Assistant Professor of Immunology in the Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Iran. He has more than 170 journal papers and 35 books to his credit. He is also an editorial board member of more than eighty international journals. He has several medical inventions to his credit and has recorded gene sequences in gene banks. Dr. Athari has been invited as a speaker to more than fifty international congresses and symposia. He is the recipient of several awards from scientific societies.

4books edited

3chapters authored

Latest work with IntechOpen by Seyyed Shamsadin Athari

Phagocytosis, as an innate immune defense mechanism, is the first process to respond to pathogens. It is also one of the initiating branches of an adaptive immune response. This book provides a comprehensive overview of phagocytosis and related cells in the immune response. It presents the basics of phagocytosis as well as discusses management and therapeutic strategies for infections.

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Phagocytosis

Edited by Seyyed Shamsadin Athari

Books edited

By Seyyed Shamsadin Athari and Ghasem Vahedi

Part of the book: Allergen

Introductory Chapter: Sarcoidosis – New Perspectives

By Seyyed Shamsadin Athari and Entezar Mehrabi Nasab

Part of the book: Sarcoidosis

Immunopathology of the Sarcoidosis

By Entezar Mehrabi Nasab and Seyyed Shamsadin Athari

Sarcoidosis as a multisystemic inflammatory granulomatous disorder is characterized by local immune hyperactivation, inflammation, and granuloma formation. Many organs may be involved by sarcoidosis. The pathogenesis of sarcoidosis may be autoimmune response to an antigenic exposure. The lung is affected in the vast majority of patients, and common symptoms in lung sarcoidosis are nonproductive cough and dyspnea. The death cause is typically severe pulmonary complications, involvement of myocardia, and central nervous system. Sarcoid granuloma is comprised of epithelioid, mononuclear, and CD4+ T cells with a few CD8+ T cells. It was confirmed that there is association between HLA Class I and II genes as risk factors with sarcoidosis. Some alleles have protective effect against immunopathology of sarcoidosis, and some others are risk factor. The immune mechanisms of sarcoidosis are not completely understood. The inflammasome signal transductions pathway plays a critical role in sarcoidosis pathogenesis. Sarcoidosis treatment could potentially benefit from simultaneous modulation and fine-tuning of M2/Th2 and M1/Th1 pathways rather than targeting one pathway or the other. Future experimental investigations and clinical studies into sarcoidosis and all types of sarcoid reaction may increase our understanding.

Part of the book: Sarcoidosis