\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"1845",leadTitle:null,fullTitle:"Prostate Cancer - Diagnostic and Therapeutic Advances",title:"Prostate Cancer",subtitle:"Diagnostic and Therapeutic Advances",reviewType:"peer-reviewed",abstract:'In this book entitled "Prostate Cancer - Diagnostic and Therapeutic Advances", we highlight many of the significant advances made in our treatment armamentarium of prostate cancer. The book is subdivided into four sections termed: 1) novel diagnostic approaches, 2) surgical treatments options, 3) radiation therapy and its potential sequelae, and 4) medical management and its treatment complications. After reading the present book , readers will be very familiar with the major clinical advances made in our multifaceted treatment approach to prostate cancer over the past decade.This book is a tribute to our pioneering urologists and allied healthcare professionals who have continually pushed forward our traditional therapeutic envelope.',isbn:null,printIsbn:"978-953-307-319-4",pdfIsbn:"978-953-51-6590-3",doi:"10.5772/2271",price:139,priceEur:155,priceUsd:179,slug:"prostate-cancer-diagnostic-and-therapeutic-advances",numberOfPages:392,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"3be3f6b756cec080cfcacd2251b62a5c",bookSignature:"Philippe E. Spiess",publishedDate:"November 25th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/1845.jpg",numberOfDownloads:41474,numberOfWosCitations:11,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:14,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:30,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 20th 2011",dateEndSecondStepPublish:"February 17th 2011",dateEndThirdStepPublish:"June 24th 2011",dateEndFourthStepPublish:"July 24th 2011",dateEndFifthStepPublish:"November 21st 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"64476",title:"Dr.",name:"Philippe E.",middleName:null,surname:"Spiess",slug:"philippe-e.-spiess",fullName:"Philippe E. Spiess",profilePictureURL:"https://mts.intechopen.com/storage/users/64476/images/1906_n.jpg",biography:"Dr Philippe E. Spiess is an assistant professor with dual appointment in the department of Genitourinary Oncology at the Moffitt Cancer Center and the department of Urology at the University of South Florida in Tampa, Florida. Dr Spiess was born and raised in Montreal, Canada where he completed his urological training at McGill University. He subsequently completed his urologic oncologic training at the M. D. Anderson Cancer Center in Houston, Texas. Dr Spiess has published over 80 peer reviewed scientific papers in urologic oncology in addition to being a nationally and internationally recognized expert in the management of genitourinary malignancies. He has dedicated much of his research efforts to optimizing the surgical management of locally advanced and locally recurrent prostate cancer. He currently sits on the NCCN Panel for bladder and penile cancer in addition to being the video section editor of the International Brazilian Journal of Urology.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Moffitt Cancer Center",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1079",title:"Genitourinary Oncology",slug:"genitourinary-oncology"}],chapters:[{id:"24239",title:"Biomarkers of Aggressiveness in Prostate Cancer",doi:"10.5772/25310",slug:"biomarkers-of-aggressiveness-in-prostate-cancer",totalDownloads:2024,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Cuvillier Olivier and Malavaud Bernard",downloadPdfUrl:"/chapter/pdf-download/24239",previewPdfUrl:"/chapter/pdf-preview/24239",authors:[{id:"62957",title:"Dr.",name:"Olivier",surname:"Cuvillier",slug:"olivier-cuvillier",fullName:"Olivier Cuvillier"},{id:"68334",title:"Prof.",name:"Bernard",surname:"Malavaud",slug:"bernard-malavaud",fullName:"Bernard Malavaud"}],corrections:null},{id:"24240",title:"The Influence of Obesity on Prostate Cancer Diagnosis and Treatment",doi:"10.5772/25828",slug:"the-influence-of-obesity-on-prostate-cancer-diagnosis-and-treatment",totalDownloads:1267,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Piotr Bryniarski, Andrzej Paradysz and Mieczysław Fryczkowski",downloadPdfUrl:"/chapter/pdf-download/24240",previewPdfUrl:"/chapter/pdf-preview/24240",authors:[{id:"64693",title:"PhD.",name:"Piotr",surname:"Bryniarski",slug:"piotr-bryniarski",fullName:"Piotr Bryniarski"},{id:"64700",title:"Prof.",name:"Andrzej",surname:"Paradysz",slug:"andrzej-paradysz",fullName:"Andrzej Paradysz"},{id:"64701",title:"Prof.",name:"Mieczys?aw",surname:"Fryczkowski",slug:"mieczysaw-fryczkowski",fullName:"Mieczys?aw Fryczkowski"}],corrections:null},{id:"24241",title:"Renewing Perspectives on Men's Prostate Cancer Literacy and Engagement Along the Disease Continuum",doi:"10.5772/25822",slug:"renewing-perspectives-on-men-s-prostate-cancer-literacy-and-engagement-along-the-disease-continuum",totalDownloads:2256,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Margareth Santos Zanchetta, Margot Kaszap, Marko Monteiro, Franklin Gorospe IV and Roger Pilon",downloadPdfUrl:"/chapter/pdf-download/24241",previewPdfUrl:"/chapter/pdf-preview/24241",authors:[{id:"64667",title:"Dr.",name:"Margareth",surname:"Zanchetta",slug:"margareth-zanchetta",fullName:"Margareth Zanchetta"},{id:"70170",title:"Prof.",name:"Marko",surname:"Monteiro",slug:"marko-monteiro",fullName:"Marko Monteiro"},{id:"70171",title:"Dr.",name:"Margot",surname:"Kaszap",slug:"margot-kaszap",fullName:"Margot Kaszap"},{id:"70174",title:"Mr.",name:"Roger",surname:"Pilon",slug:"roger-pilon",fullName:"Roger Pilon"},{id:"70180",title:"Prof.",name:"Franklin",surname:"Gorospe",slug:"franklin-gorospe",fullName:"Franklin Gorospe"}],corrections:null},{id:"24242",title:"Prostate Specific Membrane Antigen as Biomarker and Therapeutic Target for Prostate Cancer",doi:"10.5772/26951",slug:"prostate-specific-membrane-antigen-as-biomarker-and-therapeutic-target-for-prostate-cancer",totalDownloads:3209,totalCrossrefCites:2,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Philipp Wolf",downloadPdfUrl:"/chapter/pdf-download/24242",previewPdfUrl:"/chapter/pdf-preview/24242",authors:[{id:"68380",title:"Dr.",name:"Philipp",surname:"Wolf",slug:"philipp-wolf",fullName:"Philipp Wolf"}],corrections:null},{id:"24243",title:"Future of Prostate Biopsy: Who Will Get It and How?",doi:"10.5772/25588",slug:"future-of-prostate-biopsy-who-will-get-it-and-how-",totalDownloads:2892,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Tine Hajdinjak",downloadPdfUrl:"/chapter/pdf-download/24243",previewPdfUrl:"/chapter/pdf-preview/24243",authors:[{id:"63835",title:"Dr.",name:"Tine",surname:"Hajdinjak",slug:"tine-hajdinjak",fullName:"Tine Hajdinjak"}],corrections:null},{id:"24244",title:"Radical Prostatectomy in High Risk Prostate Cancer",doi:"10.5772/25693",slug:"radical-prostatectomy-in-high-risk-prostate-cancer",totalDownloads:2771,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Jorge Rioja, Carlos Blanco and Jorge Aranda",downloadPdfUrl:"/chapter/pdf-download/24244",previewPdfUrl:"/chapter/pdf-preview/24244",authors:[{id:"64201",title:"Dr.",name:"Jorge",surname:"Rioja Zuazu",slug:"jorge-rioja-zuazu",fullName:"Jorge Rioja Zuazu"},{id:"70837",title:"Mr.",name:"Carlos",surname:"Blanco",slug:"carlos-blanco",fullName:"Carlos Blanco"},{id:"70838",title:"Mr.",name:"Jorge",surname:"Aranda",slug:"jorge-aranda",fullName:"Jorge Aranda"}],corrections:null},{id:"24245",title:"High-Intensity Focused Ultrasound (HIFU) - An Alternative Choice in Prostate Cancer Treatment",doi:"10.5772/25029",slug:"high-intensity-focused-ultrasound-hifu-an-alternative-choice-in-prostate-cancer-treatment",totalDownloads:2766,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Umberto Maestroni and Francesco Ziglioli",downloadPdfUrl:"/chapter/pdf-download/24245",previewPdfUrl:"/chapter/pdf-preview/24245",authors:[{id:"61181",title:"Dr.",name:"Umberto",surname:"Maestroni",slug:"umberto-maestroni",fullName:"Umberto Maestroni"},{id:"62240",title:"Dr.",name:"Francesco",surname:"Ziglioli",slug:"francesco-ziglioli",fullName:"Francesco Ziglioli"}],corrections:null},{id:"24246",title:"Radiotherapy in Prostate Cancer",doi:"10.5772/25784",slug:"radiotherapy-in-prostate-cancer",totalDownloads:4032,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Tatjana Arsenijević, Kata Dabić Stanković, Miodrag Aćimović and Ljiljana Radošević Jelić",downloadPdfUrl:"/chapter/pdf-download/24246",previewPdfUrl:"/chapter/pdf-preview/24246",authors:[{id:"64539",title:"Dr.",name:"Tatjana",surname:"Arsenijevic",slug:"tatjana-arsenijevic",fullName:"Tatjana Arsenijevic"},{id:"118162",title:"Dr.",name:"Kata",surname:"Dabic-Stankovic",slug:"kata-dabic-stankovic",fullName:"Kata Dabic-Stankovic"},{id:"118282",title:"Prof.",name:"Ljiljana",surname:"Radosevic-Jelic",slug:"ljiljana-radosevic-jelic",fullName:"Ljiljana Radosevic-Jelic"},{id:"118459",title:"Prof.",name:"Acimovic",surname:"Miodrag",slug:"acimovic-miodrag",fullName:"Acimovic Miodrag"}],corrections:null},{id:"24247",title:"Combination of Immunotherapy & Radiotherapy for the Treatment of Prostate Cancer",doi:"10.5772/27790",slug:"combination-of-immunotherapy-radiotherapy-for-the-treatment-of-prostate-cancer",totalDownloads:1956,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Zsuzsanna Tabi, Lisa K. Spary and John Staffurth",downloadPdfUrl:"/chapter/pdf-download/24247",previewPdfUrl:"/chapter/pdf-preview/24247",authors:[{id:"71544",title:"Dr.",name:"Zsuzsanna",surname:"Tabi",slug:"zsuzsanna-tabi",fullName:"Zsuzsanna Tabi"},{id:"71583",title:"Dr.",name:"John",surname:"Staffurth",slug:"john-staffurth",fullName:"John Staffurth"},{id:"71584",title:"Dr.",name:"Lisa",surname:"Spary",slug:"lisa-spary",fullName:"Lisa Spary"}],corrections:null},{id:"24248",title:"Bone Seeking Radiopharmaceuticals for Metastatic Bone Pain",doi:"10.5772/25874",slug:"bone-seeking-radiopharmaceuticals-for-metastatic-bone-pain",totalDownloads:2343,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Marnix G.E.H. Lam and Bernard A. Zonnenberg",downloadPdfUrl:"/chapter/pdf-download/24248",previewPdfUrl:"/chapter/pdf-preview/24248",authors:[{id:"64829",title:"Dr.",name:"Marnix G.E.H.",surname:"Lam",slug:"marnix-g.e.h.-lam",fullName:"Marnix G.E.H. Lam"}],corrections:null},{id:"24249",title:"Use of Radiobiological Modeling in Treatment Plan Evaluation and Optimization of Prostate Cancer Radiotherapy",doi:"10.5772/25634",slug:"use-of-radiobiological-modeling-in-treatment-plan-evaluation-and-optimization-of-prostate-cancer-rad",totalDownloads:2885,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Panayiotis Mavroidis, Dimos Baltas, Bengt K. Lind and Nikos Papanikolaou",downloadPdfUrl:"/chapter/pdf-download/24249",previewPdfUrl:"/chapter/pdf-preview/24249",authors:[{id:"63958",title:"Prof.",name:"Panayiotis",surname:"Mavroidis",slug:"panayiotis-mavroidis",fullName:"Panayiotis Mavroidis"},{id:"70854",title:"Prof.",name:"Bengt",surname:"Lind",slug:"bengt-lind",fullName:"Bengt Lind"},{id:"70855",title:"Prof.",name:"Nikos",surname:"Papanikolaou",slug:"nikos-papanikolaou",fullName:"Nikos Papanikolaou"},{id:"79882",title:"Prof.",name:"Dimos",surname:"Baltas",slug:"dimos-baltas",fullName:"Dimos Baltas"}],corrections:null},{id:"24250",title:"Current Options and Future Directions in Castrate Resistant Prostate (CRPC)",doi:"10.5772/26195",slug:"current-options-and-future-directions-in-castrate-resistant-prostate-crpc-",totalDownloads:1436,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Suzanne Richter and Srikala S. Sridhar",downloadPdfUrl:"/chapter/pdf-download/24250",previewPdfUrl:"/chapter/pdf-preview/24250",authors:[{id:"65820",title:"Dr.",name:"Kala",surname:"Sridhar",slug:"kala-sridhar",fullName:"Kala Sridhar"}],corrections:null},{id:"24251",title:"The Role of PDE-5 Inhibitors in Prostate Cancer",doi:"10.5772/25380",slug:"the-role-of-pde-5-inhibitors-in-prostate-cancer",totalDownloads:2696,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Anindita Das, Fadi N. Salloum and Rakesh C. Kukreja",downloadPdfUrl:"/chapter/pdf-download/24251",previewPdfUrl:"/chapter/pdf-preview/24251",authors:[{id:"63133",title:"Dr.",name:"Anindita",surname:"Das",slug:"anindita-das",fullName:"Anindita Das"},{id:"63137",title:"Dr.",name:"Fadi",surname:"Salloum",slug:"fadi-salloum",fullName:"Fadi Salloum"},{id:"63138",title:"Prof.",name:"Rakesh",surname:"Kukreja",slug:"rakesh-kukreja",fullName:"Rakesh Kukreja"}],corrections:null},{id:"24252",title:"Entering a New Era – Prostate Cancer Immuno-Therapy After the FDA Approval for Sipuleucel-T",doi:"10.5772/25553",slug:"entering-a-new-era-prostate-cancer-immuno-therapy-after-the-fda-approval-for-sipuleucel-t",totalDownloads:1512,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Thomas H. Brill",downloadPdfUrl:"/chapter/pdf-download/24252",previewPdfUrl:"/chapter/pdf-preview/24252",authors:[{id:"63709",title:"Dr.",name:"Thomas H.",surname:"Brill",slug:"thomas-h.-brill",fullName:"Thomas H. Brill"}],corrections:null},{id:"24253",title:"Skeletal Related Events in Prostate Cancer: Important Therapeutic Considerations",doi:"10.5772/25560",slug:"skeletal-related-events-in-prostate-cancer-important-therapeutic-considerations",totalDownloads:1859,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Miguel Álvarez Múgica, Jesús Ma Fernández Gómez, Antonio Jalón Monzón, Verónica Bulnes Vázquez, Erasmo Miguelez and Francisco Valle González",downloadPdfUrl:"/chapter/pdf-download/24253",previewPdfUrl:"/chapter/pdf-preview/24253",authors:[{id:"63733",title:"Dr.",name:"Miguel",surname:"Álvarez-Múgica",slug:"miguel-alvarez-mugica",fullName:"Miguel Álvarez-Múgica"},{id:"117909",title:"Prof.",name:"Jesus María",surname:"Fernández Gómez",slug:"jesus-maria-fernandez-gomez",fullName:"Jesus María Fernández Gómez"},{id:"117910",title:"Dr.",name:"Antonio",surname:"Jalón Monzón",slug:"antonio-jalon-monzon",fullName:"Antonio Jalón Monzón"},{id:"117912",title:"Dr.",name:"Verónica",surname:"Bulnes Vázquez",slug:"veronica-bulnes-vazquez",fullName:"Verónica Bulnes Vázquez"},{id:"122952",title:"Dr.",name:"Erasmo",surname:"Miguelez",slug:"erasmo-miguelez",fullName:"Erasmo Miguelez"},{id:"122953",title:"Dr.",name:"Francisco",surname:"Valle González",slug:"francisco-valle-gonzandatildeandiexcllez",fullName:"Francisco Valle González"}],corrections:null},{id:"24254",title:"Androgen Deprivation Therapy for Prostate Cancer",doi:"10.5772/28243",slug:"androgen-deprivation-therapy-for-prostate-cancer",totalDownloads:1947,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Stanislav Ziaran",downloadPdfUrl:"/chapter/pdf-download/24254",previewPdfUrl:"/chapter/pdf-preview/24254",authors:[{id:"73226",title:"Dr.",name:"Stanislav",surname:"Ziaran, PhD., Mph, Febu",slug:"stanislav-ziaran-phd.-mph-febu",fullName:"Stanislav Ziaran, PhD., Mph, Febu"}],corrections:null},{id:"24255",title:"A Review of Quality of Life Following Treatments for Localized Prostate Cancer",doi:"10.5772/25434",slug:"a-review-of-quality-of-life-following-treatments-for-localized-prostate-cancer",totalDownloads:1910,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sunao Shoji",downloadPdfUrl:"/chapter/pdf-download/24255",previewPdfUrl:"/chapter/pdf-preview/24255",authors:[{id:"63316",title:"Dr.",name:"Sunao",surname:"Shoji",slug:"sunao-shoji",fullName:"Sunao Shoji"}],corrections:null},{id:"24256",title:"Intermittent Androgen Suppression Therapy for Prostate Cancer Patients: A Choice for Improved Quality of Life?",doi:"10.5772/26778",slug:"intermittent-androgen-suppression-therapy-for-prostate-cancer-patients-a-choice-for-improved-quality",totalDownloads:1714,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Gerhard Hamilton, Ulrike Olszewski-Hamilton and Gerhard Theyer",downloadPdfUrl:"/chapter/pdf-download/24256",previewPdfUrl:"/chapter/pdf-preview/24256",authors:[{id:"67794",title:"Prof.",name:"Gerhard",surname:"Hamilton",slug:"gerhard-hamilton",fullName:"Gerhard Hamilton"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1985",title:"Prostate Cancer",subtitle:"Original Scientific Reports and Case Studies",isOpenForSubmission:!1,hash:"51d83bcaa97cb41331a0e6cc466f237f",slug:"prostate-cancer-original-scientific-reports-and-case-studies",bookSignature:"Philippe E. Spiess",coverURL:"https://cdn.intechopen.com/books/images_new/1985.jpg",editedByType:"Edited by",editors:[{id:"64476",title:"Dr.",name:"Philippe E.",surname:"Spiess",slug:"philippe-e.-spiess",fullName:"Philippe E. Spiess"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"777",title:"Prostate Cancer",subtitle:"From Bench to Bedside",isOpenForSubmission:!1,hash:"d5a01877eb8f560e8aeee899be80f547",slug:"prostate-cancer-from-bench-to-bedside",bookSignature:"Philippe E. Spiess",coverURL:"https://cdn.intechopen.com/books/images_new/777.jpg",editedByType:"Edited by",editors:[{id:"64476",title:"Dr.",name:"Philippe E.",surname:"Spiess",slug:"philippe-e.-spiess",fullName:"Philippe E. Spiess"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3274",title:"Advances in Prostate Cancer",subtitle:null,isOpenForSubmission:!1,hash:"fb7257d982e3228ceb9320f595ae1c58",slug:"advances-in-prostate-cancer",bookSignature:"Gerhard Hamilton",coverURL:"https://cdn.intechopen.com/books/images_new/3274.jpg",editedByType:"Edited by",editors:[{id:"67794",title:"Prof.",name:"Gerhard",surname:"Hamilton",slug:"gerhard-hamilton",fullName:"Gerhard Hamilton"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1312",title:"Advances in Cancer Management",subtitle:null,isOpenForSubmission:!1,hash:"dc1cad15f23e313cd067e7e7b4511005",slug:"advances-in-cancer-management",bookSignature:"Ravinder Mohan",coverURL:"https://cdn.intechopen.com/books/images_new/1312.jpg",editedByType:"Edited by",editors:[{id:"58197",title:"Prof.",name:"Ravinder",surname:"Mohan",slug:"ravinder-mohan",fullName:"Ravinder Mohan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"789",title:"Emerging Research and Treatments in Renal Cell Carcinoma",subtitle:null,isOpenForSubmission:!1,hash:"616688465519d2b5bcb1d867a3806714",slug:"emerging-research-and-treatments-in-renal-cell-carcinoma",bookSignature:"Robert J. Amato",coverURL:"https://cdn.intechopen.com/books/images_new/789.jpg",editedByType:"Edited by",editors:[{id:"73752",title:"Dr.",name:"Robert",surname:"Amato",slug:"robert-amato",fullName:"Robert Amato"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"559",title:"Bladder Cancer",subtitle:"From Basic Science to Robotic Surgery",isOpenForSubmission:!1,hash:"117cbfaa858282ed2cdb9a81ce411def",slug:"bladder-cancer-from-basic-science-to-robotic-surgery",bookSignature:"Abdullah Erdem Canda",coverURL:"https://cdn.intechopen.com/books/images_new/559.jpg",editedByType:"Edited by",editors:[{id:"69657",title:"Prof.",name:"Abdullah Erdem",surname:"Canda",slug:"abdullah-erdem-canda",fullName:"Abdullah Erdem Canda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5256",title:"Human Papillomavirus",subtitle:"Research in a Global Perspective",isOpenForSubmission:!1,hash:"8d66d3c0bc41a12be8217ca0cee52b60",slug:"human-papillomavirus-research-in-a-global-perspective",bookSignature:"Rajamanickam Rajkumar",coverURL:"https://cdn.intechopen.com/books/images_new/5256.jpg",editedByType:"Edited by",editors:[{id:"120109",title:"Dr.",name:"Rajamanickam",surname:"Rajkumar",slug:"rajamanickam-rajkumar",fullName:"Rajamanickam Rajkumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3395",title:"Human Papillomavirus and Related Diseases",subtitle:"From Bench to Bedside - A Diagnostic and Preventive Perspective",isOpenForSubmission:!1,hash:"c6c3820fb6deb675bd38fa1954ec4f56",slug:"human-papillomavirus-and-related-diseases-from-bench-to-bedside-a-diagnostic-and-preventive-perspective",bookSignature:"Davy Vanden Broeck",coverURL:"https://cdn.intechopen.com/books/images_new/3395.jpg",editedByType:"Edited by",editors:[{id:"93213",title:"Dr.",name:"Davy",surname:"Vanden Broeck",slug:"davy-vanden-broeck",fullName:"Davy Vanden Broeck"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"960",title:"Cancer of the Uterine Endometrium",subtitle:"Advances and Controversies",isOpenForSubmission:!1,hash:"e31a8846983568317bbe451b6e32b4c6",slug:"cancer-of-the-uterine-endometrium-advances-and-controversies",bookSignature:"J. Salvador Saldivar",coverURL:"https://cdn.intechopen.com/books/images_new/960.jpg",editedByType:"Edited by",editors:[{id:"71352",title:"Dr.",name:"J.S.",surname:"Saldivar",slug:"j.s.-saldivar",fullName:"J.S. Saldivar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3441",title:"Renal Tumor",subtitle:null,isOpenForSubmission:!1,hash:"8113c9de84f8da9eec92bea7f394e8ef",slug:"renal-tumor",bookSignature:"Jindong Chen",coverURL:"https://cdn.intechopen.com/books/images_new/3441.jpg",editedByType:"Edited by",editors:[{id:"158564",title:"Prof.",name:"Jindong",surname:"Chen",slug:"jindong-chen",fullName:"Jindong Chen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"corrigendum-to-eating-disorders-as-new-forms-of-addiction",title:"Corrigendum to: Eating Disorders as New Forms of Addiction",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/66065.pdf",downloadPdfUrl:"/chapter/pdf-download/66065",previewPdfUrl:"/chapter/pdf-preview/66065",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/66065",risUrl:"/chapter/ris/66065",chapter:{id:"52200",slug:"eating-disorders-as-new-forms-of-addiction",signatures:"Francisco J. Vaz-Leal, María I. Ramos-Fuentes, Laura Rodríguez-\nSantos and M. Cristina Álvarez-Mateos",dateSubmitted:"June 28th 2016",dateReviewed:"August 12th 2016",datePrePublished:null,datePublished:"February 1st 2017",book:{id:"5372",title:"Eating Disorders",subtitle:"A Paradigm of the Biopsychosocial Model of Illness",fullTitle:"Eating Disorders - A Paradigm of the Biopsychosocial Model of Illness",slug:"eating-disorders-a-paradigm-of-the-biopsychosocial-model-of-illness",publishedDate:"February 1st 2017",bookSignature:"Ignacio Jauregui-Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/5372.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"323887",title:"Prof.",name:"Ignacio",middleName:null,surname:"Jáuregui-Lobera",slug:"ignacio-jauregui-lobera",fullName:"Ignacio Jáuregui-Lobera"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"188555",title:"Prof.",name:"Francisco J.",middleName:null,surname:"Vaz-Leal",fullName:"Francisco J. Vaz-Leal",slug:"francisco-j.-vaz-leal",email:"fjvazleal@gmail.com",position:null,institution:null},{id:"188719",title:"Dr.",name:"María Cristina",middleName:null,surname:"Álvarez Mateos",fullName:"María Cristina Álvarez Mateos",slug:"maria-cristina-alvarez-mateos",email:"cristinaalvarezmateos@gmail.com",position:null,institution:null},{id:"195142",title:"Dr.",name:"Laura",middleName:null,surname:"Rodríguez Santos",fullName:"Laura Rodríguez Santos",slug:"laura-rodriguez-santos",email:"laura@unex.es",position:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}},{id:"195143",title:"Dr.",name:"María I",middleName:null,surname:"Ramos Fuentes",fullName:"María I Ramos Fuentes",slug:"maria-i-ramos-fuentes",email:"miramos@unex.es",position:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]}},chapter:{id:"52200",slug:"eating-disorders-as-new-forms-of-addiction",signatures:"Francisco J. Vaz-Leal, María I. Ramos-Fuentes, Laura Rodríguez-\nSantos and M. Cristina Álvarez-Mateos",dateSubmitted:"June 28th 2016",dateReviewed:"August 12th 2016",datePrePublished:null,datePublished:"February 1st 2017",book:{id:"5372",title:"Eating Disorders",subtitle:"A Paradigm of the Biopsychosocial Model of Illness",fullTitle:"Eating Disorders - A Paradigm of the Biopsychosocial Model of Illness",slug:"eating-disorders-a-paradigm-of-the-biopsychosocial-model-of-illness",publishedDate:"February 1st 2017",bookSignature:"Ignacio Jauregui-Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/5372.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"323887",title:"Prof.",name:"Ignacio",middleName:null,surname:"Jáuregui-Lobera",slug:"ignacio-jauregui-lobera",fullName:"Ignacio Jáuregui-Lobera"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"188555",title:"Prof.",name:"Francisco J.",middleName:null,surname:"Vaz-Leal",fullName:"Francisco J. Vaz-Leal",slug:"francisco-j.-vaz-leal",email:"fjvazleal@gmail.com",position:null,institution:null},{id:"188719",title:"Dr.",name:"María Cristina",middleName:null,surname:"Álvarez Mateos",fullName:"María Cristina Álvarez Mateos",slug:"maria-cristina-alvarez-mateos",email:"cristinaalvarezmateos@gmail.com",position:null,institution:null},{id:"195142",title:"Dr.",name:"Laura",middleName:null,surname:"Rodríguez Santos",fullName:"Laura Rodríguez Santos",slug:"laura-rodriguez-santos",email:"laura@unex.es",position:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}},{id:"195143",title:"Dr.",name:"María I",middleName:null,surname:"Ramos Fuentes",fullName:"María I Ramos Fuentes",slug:"maria-i-ramos-fuentes",email:"miramos@unex.es",position:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},book:{id:"5372",title:"Eating Disorders",subtitle:"A Paradigm of the Biopsychosocial Model of Illness",fullTitle:"Eating Disorders - A Paradigm of the Biopsychosocial Model of Illness",slug:"eating-disorders-a-paradigm-of-the-biopsychosocial-model-of-illness",publishedDate:"February 1st 2017",bookSignature:"Ignacio Jauregui-Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/5372.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"323887",title:"Prof.",name:"Ignacio",middleName:null,surname:"Jáuregui-Lobera",slug:"ignacio-jauregui-lobera",fullName:"Ignacio Jáuregui-Lobera"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11521",leadTitle:null,title:"Internal Combustion Engines - Recent Advances",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThe UN Climate Change Conference, UK 2021, came up with the Zero-Emission Vehicles Transition Council: 2022 Action Plan, with this highlighted statement: "We have agreed that our shared aim is to make zero-emission vehicles the new normal by making them accessible, affordable, and sustainable in all regions by 2030". At face value, this statement spells doom for the internal combustion engine. Though we desire to have zero-emission vehicles as soon as possible, however, practical realities will not make this possible as quickly as we want! MOTORTREND succinctly captured this essence in its feature article, HOW GASOLINE ENGINES CAN SURVIVE IN AN ELECTRIC CAR FUTURE "Advancing technology can keep conventional engines humming for decades. Combustion engines won't completely disappear any time soon, if ever. Certain transportation tasks or operating environments simply don't lend themselves to the battery- or hydrogen-powered electric propulsion. A century and a half of research and development have greatly increased the efficiency of combustion engines, and engineers have loads of additional tricks up their sleeves that promise to extract even more work from a molecule of fuel while producing even fewer harmful emissions". Therefore, the internal combustion engine will continue to be around for decades to come. Thus, the purpose of this book will be to bring together all current research and development work on the internal combustion engine targeted at further reducing its harmful emissions, to have an environmentally sustainable world even with its use.
",isbn:"978-1-80356-909-3",printIsbn:"978-1-80356-908-6",pdfIsbn:"978-1-80356-910-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"99cc881bcb3efe05085f2728ccbeab6b",bookSignature:"Prof. Akaehomen Akii Ibhadode",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11521.jpg",keywords:"Power Losses, Lightweighting, Downsizing, New Configurations, Biofuels, Synthetic Fuels, Fossil Fuels, Other Fuels, Carbon Dioxide, Carbon Monoxide, Hydrocarbons, Particulate Matter",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 5th 2022",dateEndSecondStepPublish:"June 14th 2022",dateEndThirdStepPublish:"August 13th 2022",dateEndFourthStepPublish:"November 1st 2022",dateEndFifthStepPublish:"December 31st 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Prof. Akaehomen Ibhadode is a researcher in IC engine, manufacturing engineering, and former Shell Professor of Lightweight Automobile Engine Development (2016 - 2020). He is a Fellow of the Nigerian Academy of Science, the Nigerian Society of Engineers, the Materials Science and Technology Society, and the Solar Energy Society of Nigeria. He holds four patents. He was the winner of the Nigeria Prize for Science and the winner of the Edwin Walker Prize of the Institution of Mechanical Engineers, UK.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"253342",title:"Prof.",name:"Akaehomen",middleName:"Akii",surname:"Ibhadode",slug:"akaehomen-ibhadode",fullName:"Akaehomen Ibhadode",profilePictureURL:"https://mts.intechopen.com/storage/users/253342/images/system/253342.jpg",biography:"AKII IBHADODE is a distinguished Professor of Manufacturing Engineering and former Shell Professor of Lightweight Automobile Engine Development (2016 - 2020). He was the Vice-Chancellor of the Federal University of Petroleum Resources, Nigeria from 2015 - 2020. He obtained a B.Sc. (Mechanical Engineering), University of Lagos in 1981, M.Eng. (Production Engineering), University of Benin in 1984, both in Nigeria, and a Ph.D. (Mechanical Engineering), University of Birmingham, United Kingdom in 1987. He has pioneered a number of researches leading to patents and industrial products. \n\nHe was the winner of the Nigeria Prize for Science (2010) of the Nigerian Academy of Science sponsored by the Nigerian Liquefied Natural Gas Limited, and the winner of the Edwin Walker Prize for 1988 of the Institution of Mechanical Engineers, United Kingdom. Since 2013 till date, he has mentored student teams which design and build Shell Eco-marathon Competition vehicles. He has supervised over one hundred M.Sc/Ph.D students. \n\nProf. Ibhadode is a Fellow of the Nigerian Academy of Science; Fellow of the Nigerian Society of Engineers; Fellow of the Materials Science and Technology Society of Nigeria, and Fellow of the Solar Energy Society of Nigeria, Chartered Engineer of the Council for the Regulation of Engineering in Nigeria; editor and reviewer of a number of journals among which is the International Journal of Engineering Research in Africa (JERA) published by Trans Tech Publications, Switzerland which he founded in 2009 and is the Editor-in-Chief.",institutionString:"University of Benin",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Benin",institutionURL:null,country:{name:"Nigeria"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"53596",title:"Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter",doi:"10.5772/66711",slug:"allergen-specific-immunotherapy-follow-up-by-measuring-allergen-specific-igg-as-an-objective-paramet",body:'\nAllergen‐specific immunotherapy (AIT) is indicated for atopic patients with IgE‐mediated allergic diseases, particularly in allergic rhinitis, mild or moderate asthma and hymenoptera sting allergy. AIT is an effective treatment that aims to induce changes in immune response against specific allergen components derived from causal agents instead of the exteriorized symptoms, helping for modifying the natural course of the allergic disease and improving the patients’ quality of life by the reduction of symptoms and medication use when naturally exposed to sensitized allergens. It involves a build‐up phase that consists of the administration of gradually increasing levels of specific allergens until an effective dose that enables the reduction of the severity of the disease is reached, even in the presence of the natural allergen exposure [1].
\nOn the one hand, the classical respiratory allergic disease is mediated by IgE antibodies to indoor or outdoor inhalant allergens through the development of Th2 cells that produce a well‐known cytokine profile, including IL‐4 and IL‐13 [2]. These cytokines are crucial to cause antibody class switch on B cells to induce the synthesis of IgE antibodies, which in turn bind to mast cells and basophils that possess Fc epsilon receptor (FcεR types I or II) on their membranes, inducing the sensitization phase. In subsequent contacts, allergens containing genuine‐ or cross‐reactive epitopes capable to cross‐link to IgE bound to target cells can activate these cells, with consequent release of preformed and newly formed vasoactive mediators. The preformed mediators (histamine) are responsible for early phase symptoms and newly formed those (leukotrienes and cytokines) for inducing a late‐phase response, characterizing the type I hypersensitivity reaction [3].
\nOn the other hand, the administration of allergens by AIT has been proved to cause early allergen‐specific mast cell desensitization, likely as a consequence of the development of regulatory T cells (Tr1 cells) that particularly produce IL‐10, which induces antibody class switch on B cells to produce IgG4 antibody subclass. An alternative way to produce other subclasses of IgG can be achieved due to the fact that AIT can provoke immune deviation from Th2 in favor of Th1 responses that culminate in the production of IFN‐γ, which induces B cells to produce IgG1 subclass [4]. In the initial phase of AIT the immunological response involves the production of IgG1 antibodies whereas IgG4 is the dominant subclass in prolonged AIT. Therefore, IgG antibodies induced by AIT may act as blocking antibodies, reflecting in the reduction of mast cell activation and degranulation as well as competing with IgE antibodies for allergen binding, blocking IgE‐dependent mast cell activation and inhibiting IgE‐facilitated allergen presentation [1].
\nCurrently, there is no routine laboratorial test for the detection of allergen‐specific IgG antibodies, particularly IgG1 and IgG4 subclasses. Physicians, who assist patients with respiratory allergy that have been submitted to AIT, are following the treatment of such patients only by subjective clinical parameters. The possibility of following such patients under AIT by laboratorial evaluation of allergen‐specific IgG1 and/or IgG4 levels has stimulated researchers to develop objective methods for quantifying allergen‐specific IgG antibodies.
\nThe detection of IgG antibodies, particularly IgG1 and IgG4 subclasses, against specific allergenic components, such as the major allergens of
Therefore, it becomes particularly interesting the development of a method for quantifying IgG subclasses against clinically relevant allergens. These antibodies can be detected in the serum or other biological fluids, such as saliva from patients with allergic respiratory disease using an immunoenzymatic technique (reverse ELISA) and allergen component‐specific monoclonal antibodies for monitoring patients under AIT. This assay represents a potential tool for monitoring patients with respiratory allergy, especially during AIT.
The balance of the different subsets of T helper cells such as Th1, Th2 and Treg with their cytokine profiles supports the maintenance of the homeostasis of the immune system. The breakdown of this balance among Th1, Th2 and Treg cells leads to excessive activation of Th1 or Th2 cells, culminating in the development of autoimmune diseases or induction of IgE‐mediated allergic diseases, respectively [2]. Allergies are one of the most prevalent diseases in the world, once they are a result of a breakdown in the immune tolerance that individuals usually have to food, inhalant and insect venom allergens [7, 8]. These diseases have a mechanism of response based on an interaction of the innate and adaptive immune system, with interaction of various cell types, cytokines, chemokines and costimulatory signals responsible for different T‐cell responses [9].
\nTh2‐cell subset is induced in a classical respiratory allergic disease, triggering a pathogenesis related to several indoor or outdoor inhalant allergens as excretions of house dust mite and cockroaches, animal dander, pollens and fungal spores, among others [10]. In addition, the dose and function of the allergen are relevant for allergic sensitization [7]. This step is the first event of the classical pathogenesis, which is mediated by producing specific IgE antibodies directed to epitopes derived from inhalant allergens through the development of Th2 cells. First of all, the allergens can pass through the epithelial tissue cells of the respiratory tract or directly bind in receptors of innate immune cells. Then, allergens are uptaken and processed by professional antigen‐presenting cells (APCs), as dendritic cells (DCs), that present peptides through class II major histocompatibility complexes (MHC II) to naive CD4+ T cells located in the submucosal layer, driving to effector and memory T cells of the Th2 phenotype (Figure 1) [11]. For that, APCs mediate the production and secretion of crucial cytokines as IL‐4, characterizing the occurrence of the third signal of the immune response, which will be responsible for the STAT‐6 activation and subsequently GATA‐3 (GATA‐binding protein 3 transcription factor) upregulation [12]. Besides the antigenic peptide presentation (first signal of the immune response), the participation of costimulatory molecules (second signal) is necessary to reach the development of Th2 cells by increasing the expression of genes encoded on 5q31‐33 chromosome (Figure 1). These genes are associated to IL‐3, IL‐4, IL‐5, IL‐9, IL‐13 cytokines and granulocyte‐macrophage colony stimulating factor (GM‐CSF) codification, related to Th2 pathway [13]. Some of these cytokines, such as IL‐4 and IL‐13, are responsible for switching the antibody class on B cell to induce the synthesis of IgE antibodies, which bind certain target cells that possess Fc epsilon receptor (FcεR) type I (high‐affinity) or type II (low‐affinity) on their membranes like mast cells and basophils, leading to the establishment of the sensitization phase [14].
Innate and adaptive allergic immune response. Sequential events for allergen sensitization and triggering the immune response that generates different allergic diseases depending on the affected organs are shown. CD4+: cluster of differentiation 4; DC: dendritic cell; GATA‐3: GATA‐binding protein 3 transcription factor; ILC2: group 2 innate lymphoid cell; LPS: lipopolysaccharide; NF‐κB: nuclear factor kappa B; PAR: protease‐activated receptor; STAT‐5: signal transducer and activator of transcription 5; STAT‐6: signal transducer and activator of transcription 6; TLR4: Toll‐like receptor type 4; TSLP: thymic stromal lymphopoietin.
Some allergens, as proteolytic protein or lipopolysaccharide (LPS), can stimulate other bias of Th2 response, once the linkage of proteolytic allergens to pattern recognition receptors (PRRs) like protease‐activator receptors (PARs), or a linkage of LPS to toll‐like receptors (TLRs), both localized in barrier epithelial cells, or even the production of reactive oxygen species (ROS) by damaged cells can promote various effects that drive to a proinflammatory response. For instance, PARs and TLRs can be a trigger to epithelial cells to produce cytokines, like thymic stromal lymphopoietin (TSLP), interleukin‐25 (IL‐25) and IL‐33 related to allergic inflammation (Figure 1) [15, 16]. IL‐25 and IL‐33 can upregulate NFκ‐B, together with TSLP that activate STAT‐5 promoting an increase of Th2 genes regulation. This way stimulates the production of chemokines and cytokine release that contribute to cell migration, especially DCs, basophils and eosinophils as well as group 2 innate lymphoid cells (ILC2) involved in allergic responses (Figure 1) [17, 18].
\nTaken together, there are mechanisms that promote a Th2 pathway by GATA‐3 upregulation induced especially by IL‐4‐activated STAT‐6, or a Th2 route in which GATA‐3 expression is induced in an IL‐4 and STAT‐6‐independent manner [2]. Thus, the maintenance of Th2 responses by environmental allergens is related to the type of recognition of the allergens in the epithelial barrier, which promotes the linkage of innate and adaptive responses [19].
Allergic subjects besides mast cells and eosinophils with a greater number of IgE receptors, have an increase of IgE‐producing B cells stimulated by IL‐4 and IL‐13‐secreting Th2 subset [20]. In a subsequent contact with allergens that contain genuine‐ or cross‐reactive epitopes capable to cross‐link IgE bound to target cells, calcium‐dependent activation of these cells can occur with release of preformed vasoactive mediators as histamine responsible for the early phase symptoms and newly formed vasoactive mediators like leukotrienes and cytokines for late phase symptoms (Figure 1) [21]. These mediators are characterized by the maintenance of long‐lasting symptoms due to the continued tissue inflammation and injury, characterizing typically the type I hypersensitivity reaction. Therefore, maturation of eosinophils induced especially by IL‐5 and basophils by IL‐3 and IL‐4 are the main secreting effector cells of inflammatory mediators observed in the classical allergic response [12]. Local symptoms or systemic anaphylaxis may be observed depending the affected organ and tissues in a particular individual response to sensitized allergens (Figure 1) [21].
\nThe intensity of the immune response to allergens is crucial to develop an allergic condition mediated by IgE antibody, or a healthy condition depending on the individual gene susceptibility, environmental pollutants, features of allergens, among others [22–24]. Other antibody classes have been analyzed because of this variation of response between allergic and healthy subjects, such as IgA and IgG subclasses [23–25]. In healthy individuals, B cell response to house dust mite allergens ranges from no response to predominantly production of IgG antibodies specific to allergens, particularly IgG1 or IgG4 subclass, in the absence or low concentration of IgE. Differently, IgG levels, particularly IgG4 subclass, have also been detected in allergic subjects in addition to high levels of IgE, but IgG1 levels have been found at similar levels in both healthy and allergic individuals [26, 27].
Allergen‐specific immunotherapy (AIT) is performed by the administration of increasing concentrations of allergens (build‐up phase) up to maintenance doses, mainly given by subcutaneous, epicutaneous, oral, sublingual, or recently by intralymphatic route. AIT aims to induce changes on the immune response of allergic individuals, drawing a state of allergen‐specific tolerance, which contributes with a curative effect for a long period of time [28–32].
\nThe cellular and molecular mechanisms of AIT are diverse, involving the very early mast cell and basophil desensitization, effect on antigen‐presenting cells, modulation of T and B cell repertories as well as modification of allergen‐specific antibody responses (Figure 2) [32].
Immunological changes induced by allergen‐specific immunotherapy (AIT). Desensitization of basophil/mast cells and upregulation of markers associated with dendritic cells (DCs) driving differentiation of IL‐10‐producing Treg and Breg cells and subsequent activation of B cells to synthesize allergen‐blocking factors, particularly IgG4 and suppression of IgE antibodies during AIT are shown. AIT: allergen‐specific immunotherapy; Breg cell: regulatory B cell; CTLA‐4: cytotoxic T lymphocyte antigen‐4; DC: dendritic cell; FcεRI: high‐affinity receptor for the Fc region of immunoglobulin E (IgE); H2R: histamine H2 receptor; PD1: programmed death‐1 receptor; PDL1: programmed death ligand‐1; SCIT: subcutaneous immunotherapy; ORAL/SLIT: oral/sublingual immunotherapy; Treg cell: regulatory T cell.
Although AIT reduces the allergic inflammation mediated by IgE‐dependent mechanism over the time, a very early effect on basophil and mast cell activation status is observed just after the initiation of the therapeutic regimen, leading to a lower risk to develop anaphylactic manifestations [33–35]. The subjacent mechanism of basophil and mast cell desensitization has not been elucidated yet; however, some clues highlight this issue. AIT leads to a controlled releasing of histamine and leukotrienes by basophil and mast cells after allergen administration, producing a gradual reduction of granule content of the inflammatory mediators in these cells in patients submitted to immunotherapy [31, 33, 36], although there is not a direct evidence of diminution of intracellular vasoactive mediator amount by histological analysis. Short‐term venom immunotherapy induces desensitization of FcεRI‐mediated basophil response. The levels of mRNA and FcεRI cell‐surface expression decreased in basophil cells from patients submitted to venom immunotherapy, indicating that the reduction in FcεRI expression contributes to the phenomenon of the early basophil desensitization observed after AIT [37, 38]. On the other hand, AIT also provokes an allergen‐mediated upregulation of the type 2 histamine receptor (H2R) gene, which was associated with the suppression of FcεRI‐mediated basophil activation, inducing a tolerogenic response (Figure 2) [34, 39]. The engagement of H2R with its agonists prevents further histamine and leukotriene releasing as well as IL‐4 and IL‐8 production by basophil cells [34]. The molecular mechanism involved in H2R‐dependent basophil desensitization is supposed to be mediated by the cAMP pathway because the stimulation with H2R agonist or with a direct cAMP inducer was able to inhibit the FcεRI‐mediated basophil activation [34]. In this way, the increase of concentration of cAMP activates PKA (Protein Kinase A, the principal intracellular target of cAMP), which in turn decreases the intracellular calcium influx, thus preventing FcεRI‐dependent basophil and mast cell degranulation [22].
\nAntigen‐presenting cells, particularly dendritic cells (DC), display an important role in the induction of allergic diseases driving Th2 responses and the IgE‐dependent pathophysiologic mechanism. Some evidences reveal that AIT can affect directly the phenotype of the antigen‐presenting cells correlating with clinical improvement in patients with allergic diseases [40–42]. A regulatory dendritic cell signature correlating with the clinical efficacy after allergen‐specific sublingual immunotherapy (SLIT) has been observed in peripheral blood mononuclear cells (PBMCs) from clinical allergic responders in comparison with nonresponders or patients that received only placebo [40]. Likewise, a report using transcriptomic and proteomic approaches demonstrated that PBMCs from allergic patients downregulate the expression of markers related with DC driving the differentiation of Th2 cells, whereas upregulate markers associated with DC driving differentiation of T regulatory cells, after only 4 months of SLIT. These results indicate that AIT has an early effect on antigen‐presenting cells that trigger the Th2 downregulation [42]. Therefore, the changes evoked during AIT regimen on antigen‐presenting cells, with a predominance of DC tolerogenic subsets inducing the development of T regulatory (Treg) cells, may be part of the mechanism behind of the therapeutic efficacy observed in AIT (Figure 2).
\nThe induction of the allergen‐specific tolerance is a pivotal event required in AIT procedures by generating allergen‐specific Treg cells [43], responsible for maintaining immune homeostasis. Treg cells have been characterized by stable expression of CD25, CD4 and FOXP3 (Forkhead box protein 3), expression of suppressive surface molecules, such as cytotoxic T lymphocyte antigen‐4 (CTLA‐4) and programed death 1 (PD1) and secretion of IL‐10 and TGF‐β cytokines [31]. Accordingly, increased numbers of Treg cells were also detected in nasal mucosa correlating with clinical efficacy after AIT, supporting the importance of these cells on tolerogenic phenomenon observed in patients upon AIT [44].
\nTGF‐β produced by Treg cells is a potent inhibitor of Th2, Th1 and Th17 effector response and has been associated with the suppression of seasonal allergic inflammation [31] and production of mucosal allergen‐specific IgA after AIT [30, 45, 46]. Likewise, IL‐10 produced by Tr1, Treg and Breg cells were markedly increased after AIT in allergic individuals and those cells were also associated with suppressor effect observed in several immunotherapeutical protocols [47–49].
\nIL‐10 acts as a potent suppressor cytokine, reducing the production of proinflammatory cytokines by mast cells, decreasing the eosinophil functions and also downregulating the expression of MHC class II and costimulatory molecules on surface of monocytes/macrophages and DCs, thus preventing allergen‐induced Th2 activation [50–53]. Importantly, IL‐10 is related with the antibody class switch on B cells, favoring the production of IgG4 subclass, a dominant antibody subclass in late phase response of AIT, which is associated with a gradual decreasing of IgE levels. Alternatively, AIT can also provoke immune deviation from Th2 in favor of Th1 responses that culminate in the production of IFN‐γ, inducing preferentially B cells to produce IgG1 subclass directed to allergenic components present in the formulation of the AIT [31].
\nTherefore, allergen‐specific IgG antibodies induced during AIT may act as blocking antibodies, reflecting in the reduction of mast cell activation and degranulation due to its competition with IgE antibodies for allergen binding and inhibiting IgE‐facilitated allergen presentation [54].
In addition to clinical parameters like improvement in symptoms and medication scores that are subjective, it should be very helpful if the medical assistant had also objective parameters such as complementary laboratorial tests for the follow‐up of allergic patients under AIT.
\nConsidering the several cellular and molecular mechanisms involved in AIT described before, such as the determination of the type 2 histamine receptor (H2R), basophil activation test, or a procedure for measuring regulatory dendritic cell signature, all of which can be correlated with the clinical efficacy of AIT, it becomes evident that complex methods should be employed and certainly would be difficult to be applied in the routine analysis.
\nTherefore, we can accomplish that measurement of specific IgG, particularly of the IgG4 subclass, might be used for monitoring patients receiving AIT, since it will be more simple and feasible in any clinical analysis laboratory. In this context, a previous study has demonstrated a lack of correlation between venom‐specific total IgG levels and prediction of systemic reactions, concluding that measuring specific IgG antibodies is not useful for monitoring AIT. In this study, the authors postulated that IgG subclasses could be probably involved, since the clinical improvement is not necessarily reflected in the total IgG antibody titre [55]. However, other investigators have found a correlation between low levels of venom‐specific IgG and a greater risk of anaphylaxis in patients submitted to venom allergen immunotherapy during 4 years and the opposite was also true, a lower risk of systemic reaction could be observed in those patients with high levels of venom‐specific IgG, concluding that the measurement of specific IgG is useful and beneficial, especially for advising greater risk of anaphylaxis in patients who present low levels of specific IgG [56]. An interpretation that we can point out is the existence of two groups of patients who are receiving AIT; one group includes the good responders and another those patients that are non‐ or low‐responders and such fact can be associated to their intrinsic genetic features, particularly related to the specific type of HLA (human leukocyte antigen). Also, we need to consider the presence of pre‐existing levels of allergen‐specific IgG subclasses before AIT, since the patients themselves may present stimulation of their immune system for attempting to synthesize blocking antibodies as an autoregulatory mechanism.
\nRecent experimental study using a high‐dose cutaneous exposure to
In addition, a study employing a nonclassical allergen intralymphatic immunotherapy using a modular antigen transporter Fel d 1 (MAT‐Fel d 1) has found a strong increase in allergen‐specific IgG4 levels and some increase in IgG2 antibody subclasses, but this procedure was not able to stimulate the production of IgG1 and IgG3 subclasses [58].
\nThe production of specific IgG antibodies to allergens, especially IgG4 subclass, is the most important immunological change induced by AIT [59–62]. However, in some studies there is a lack of correlation between increased IgG4 titres and clinical improvement [55], since the induction of IgG4 blocking antibodies may not be reflected in serum or other biological fluid samples, requiring bioassays as the inhibition of IgE‐facilitated allergen presentation for its possible detection [63]. Accordingly, production of specific IgG4 antibodies to relevant allergenic components has been associated with the protective activity due to its function as blocking antibody through mechanisms of competition for allergen between IgG4 and cell‐bound IgE antibodies [6]. In this context, several other investigators have found that clinical improvement after mite AIT was associated with increased levels of serum specific IgG4 or ratio of specific IgG4/IgG1 [64–66].
\nUnfortunately, there is no current routine laboratorial test for the detection of allergen‐specific IgG antibodies, particularly IgG1 and IgG4 subclasses, against crude allergen extract and/or clinically relevant allergen components that could be used as a useful tool for monitoring AIT. Physicians, who assist patients with respiratory allergy that have been submitted to AIT, are following the treatment of such patients only by clinical parameters (symptoms and medication scores) that are very subjective. The possibility of following such patients under AIT using allergen‐specific IgG1 and/or IgG4 antibody measurements will enable to monitor those patients by using objective parameters in association with subjective clinical parameters. This fact has stimulated researchers to develop objective methods for quantifying those allergen‐specific IgG antibodies.
\nIn 2001, our group has developed a reverse ELISA technique for quantifying Der p 2 allergen‐specific IgE antibodies, using capture Der p 2‐specific monoclonal antibodies. This technique was developed with the intention of helping the allergy diagnosis by means of a molecular allergen component, since the presence of Der p 2 allergen‐specific IgE antibodies indicates the occurrence of an allergic response in the patient. It has also been demonstrated that this technique has a higher sensitivity related to conventional ELISA [67].
\nOn the other hand, the detection of specific IgG antibodies or particularly IgG1 and IgG4 subclasses, against Der p 2, or against any other specific allergenic component, would indicate the development of a physiological response, i.e., a defense response against dust mite allergens.
\nThus, on the basis of the information described above, it becomes particularly interesting to develop a method for quantifying IgG antibody subclasses against clinically relevant allergens. These antibodies can be detected in the serum or other biological fluids, such as saliva from patients with allergic respiratory disease using an immunoenzymatic technique (reverse ELISA) and relevant monoclonal antibodies for monitoring patients under AIT.
Part of our group has developed a reverse ELISA technique as described in the European patent application registered as EP 2232265, providing a method for measuring allergen‐specific IgG antibody subclasses, including IgG1, IgG2, IgG3 and IgG4, for monitoring patients with allergic diseases under AIT [68]. As illustrated in Figure 3, allergen‐specific monoclonal antibodies, for example, anti‐Der p 1 or anti‐Der p 2, are bound to ELISA microtitration plates in order to capture the corresponding natural allergens, Der p 1 or Der p 2, respectively, present in the crude
Representative diagram (sequential steps A to F) of the reverse enzyme‐linked immunosorbent assay (ELISA). (1) Capture allergen‐specific (Der p 1 or Der p 2) monoclonal antibody; (2) crude
The reverse ELISA (rELISA) technique for the detection of IgG antibody subclasses has a great advantage over others that use indirect ELISA [69, 70]. It does not require purified allergens or antigens, which are often too expensive or difficult to obtain in a purified and isolated form, since the natural allergen components present in the crude allergen extract are bound on the microtitration plate by the capture allergen‐specific monoclonal antibody. Another advantage of this assay is that it does not require specific and exclusive equipment, avoiding a direct dependence between the producers of the diagnostic kits or the diagnostic equipment and the consumers.
\nThe rELISA assay also demonstrated higher sensitivity than the conventional ELISA (cELISA) in the measurement of allergen‐specific IgG subclasses, particularly IgG4 antibodies, to the crude
Sensitivity of cELISA and rELISA for the measurement of IgG4 antibodies to the crude extract of
cELISA and rELISA specificity for IgG4 antibodies to the crude extract of
In our previous study [71], rELISA was also employed for monitoring specific IgG4 levels to
Levels of IgG4 antibodies to the crude extract of
Furthermore, we were also able to show a significant increase in IgG1 and IgG4 levels to
Thus, our studies have shown that increased levels of allergen‐specific IgG subclasses, particularly IgG4 and IgG1, can be detected after variable period of AIT in the serum of patients receiving mite AIT, using major natural components in the ELISA technique that allow better reaction than their modified or recombinant counterparts without the need of purified allergen components. For this reason, the measurement of specific serum IgG subclasses, particularly IgG4, should be considered as a good marker of protective or blocking antibody that may be useful for monitoring activation of tolerance‐inducing mechanisms in patients under AIT.
\nTherefore, according to the results described above, reverse ELISA has shown to be a sensitive and alternative method for measuring natural allergen‐specific serum IgG antibody subclasses, especially IgG4, providing valuable information for monitoring patients with allergic respiratory disease during AIT with peptides or native or recombinant allergens of clinical relevance.
We can conclude that IgE‐mediated allergic patients submitted to AIT usually demonstrate immunological changes, in particular, induction of allergen‐specific IgG that may act as blocking factors competing with IgE antibodies and thus contributing for ameliorating the clinical symptoms. In this context, we recommend follow these patients under AIT using clinical (symptoms and medication scores) and laboratorial (allergen‐specific IgG subclass measurement) parameters since this technique has shown to be a potential tool for monitoring these patients.
\nWe thank the following Brazilian funding agencies: CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasília, DF), CNPq (Conselho Nacional de Pesquisa e Desenvolvimento, Brasília, DF) and FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Belo Horizonte, MG). We also thank the Post‐Graduation Program in Applied Immunology and Parasitology of the Federal University of Uberlandia for the payment of the article processing charge.
A deterministic system is a system whose governing physical laws are specified so that if the state of the system at some time is known, then one can precisely predict the state at a later time. Nondeterministic systems are divided into two categories: stochastic and random. A stochastic system has governing physical laws that even if the state at some point in time is known precisely, it is impossible to determine the state of the system at a later time precisely. It is possible to determine the probability of a state, rather than the state itself. A random system is one which has no apparent governing physical laws. Practically, we treat all unpredictable systems, stochastic or random as stochastic systems, since we employ the same methods to study them. While we are unable to predict the state of a random process, we can evolve a strategy to deal with such processes. Such a strategy is based on a branch of mathematics dealing with unpredictable systems, called statistics.
Estimation is the process of extracting information from data which can be used to predict the behavior of state variables in a system. The estimation uses statistical criteria to infer the actual value of unknown variables. Estimation models are used to process noisy measurements, filter them, and detect inaccuracies. When random signals are passed through a deterministic system, their statistical properties are modified. A deterministic system to which random signals are input, so that the output is a random signal with desired statistical properties is called a filter. Filters can be linear or nonlinear, time-invariant or time varying. However, for simplicity we will usually consider linear, time-invariant filters. Linear, time-invariant filters are commonly employed in control systems to reduce the effect of measurement noise on the control system. In such systems, the output is usually a superposition of a deterministic signal and a random measurement noise.
The output of a filter not only has a frequency content different from the input signal, but also certain other characteristics of the filter, such as a phase-shift or a change in magnitude. In other words, the signal passing through a filter is also distorted by the filter, which is undesirable. A filter would produce an output signal based upon its characteristics, described by the transfer-function, frequency or impulse response, or a state-space representation of the filter. However, a filter can be designed to achieve a desired set of performance objectives, i.e. the numerator and denominator polynomials of the filter’s transfer function, or coefficient matrices of the filter’s state-space model, can be selected by a design process to achieve the conflicting requirements of maximum noise attenuation and minimum signal distortion.
There are several prediction models to infer the system state, although, it can be shown that of all estimation tools Kalman Filter (KF) is the one that minimizes the variance of the estimation error which enables accurate estimation of the process.
The first application of state estimation was in the aerospace field to solve problems related to the prediction of position in aerospace vehicles. Nowadays, estimation has been applied in several fields of engineering and control systems. One common application is in data acquisition, to solve the problem of predicting the state of a system that cannot be measured directly due to the characteristics and complexity of the environment.
KF is an estimator proposed by Rudolph E. Kalman in 1960. It is an algorithm to estimate the evolution of a dynamic system, especially when data has a lot of noise. The principle of the filter is to find the probability of the hypothesis of predicted state and using the data from the measurement to correct it and improve the future estimation at each time. It is a suitable algorithm to apply in dynamic systems, linking real-time measurements and predicting the state of system parameters through time approaches. KF has been implemented in several fields, such as in navigation systems [1, 2, 3, 4], financial models [5, 6, 7], tracking vehicles [8, 9] and image processing [10, 11, 12]; only to mention some of them. Nevertheless, this statistical tool is useful for two main purposes: estimation and performance analysis of estimators.
In the field of IC technology, it has been implemented for thermal estimation. Multicore processors use a dynamic thermal management mechanism that use embedded thermal sensors for monitoring the real-time thermal behavior of the processor, this kind of sensors are susceptible to a variety of source of noise and this causes the discrepancies between actual temperatures observed by on-chip thermal sensors. Therefore, to fix the discrepancies in sensing, Kalman’s prediction is used to estimate real values from noisy sensor readings [13]. Another novel application of KF is in the electric vehicle industry, the estimation of the charge state of lithium-ion battery is an important parameter in order to guarantee a safe operation of them. The battery performance is influenced by aging; this fact makes difficult to predict the battery state, to overcome this issue the application of KF in combination with other methods is a suitable methodology [14, 15, 16, 17].
Recently, KF has been applied in several industrial applications. With the development of manufacturing process, welding automation emerges as one important tool to speed up the production rate in the assembly line in stronger and high-quality welds. Nevertheless, there are several factors that could influence the welding quality and the most important is the arc length, which could be influenced by the irregular surface of the workpiece and the loss of the tungsten electrode. To enhance the quality during the Gas-Tungsten Arc Welding (GTAW) process, KF is applied in order to keep the arc length stable and minimize the external noise [18]. In the field of sensorless control, KF have been used in intelligence electrical drives. To control induction motor drives without mechanical speed sensor at the motor shaft allows reduced hardware complexity, and low costs. Additionally, the use of induction motors without position sensor is useful for applications with abrasive and hard surface. Thereby, the application of an estimation method it’s necessary in order to predict the position and velocity of the shaft [19, 20, 21].
In applications related with radio astronomy, KF has been applied for the analysis of Very-Long-Baseline Interferometry (VLBI) data, in order to analyze parameters such as base line lengths, earth orientation parameters, radio source coordinates and tropospheric delays. Nowadays, modern antennas are being constructed and equipped with highly accurate broadband receiving systems. Besides the accurate observations gotten by astronomic instruments, it is necessary to implement estimation methods in order to optimize the models applied in data analysis [22, 23]. In power systems, one of the main difficulties is power quality due to total harmonics distortion (THD) that is mainly caused by nonlinear loads. THD effects are strongly correlated with issues as device heating, break down electronic components, network interference, etc. Several filters have been performed to decrease the effect of harmonics; nevertheless, the application of KF has shown an important reduction in the effect of harmonics [24, 25, 26]. In the field of biomedicine KF is widely used over other estimation methodologies to overcome the different sources of noise. Specifically, KF has been used to smooth and predict signals from Electroencephalogram and Electrocardiogram signals [27, 28]. Recently in the literature there are reports on a new methodology to protect the confidentiality of the transmitted data based on a Kalman filter. This strategy proposes the implementation of encrypted algorithm using KF, and is suggested to be used in Industrial cyber–physical systems (ICPSs) to protected data privacy [29, 30].
As it has been mentioned above, KF has been used in diverse fields of science and technology to predict specific parameters of interest according to the application. Temperature evolution is an important parameter to measure and predict, in order to study or control the temperature in an environment [31, 32], device [13, 33, 34] and process [18]. It is well known that RTDs are commercial devices very useful to monitor the temperature due their stability and accuracy. However, RTDs are self-heating causing noisy readings making the RTD a suitable example to implement KF for temperature estimation. Importantly, we searched in the literature and found no evidence of previous work reporting the use of a KF to filter the noise and predict the temperature behavior from RTD readings.
The final objective of this study is to obtain the specification of a linear dynamic system (Wiener filter [35]) which accomplishes the prediction, separation, or detection of a random signal [36]. With the state-transition method, a single derivation covers a large variety of problems: growing and infinite memory filters, stationary and non-stationary statistics, etc. Having guessed the “state” of the estimation (i.e., filtering or prediction) problem correctly, one is led to a nonlinear difference (or differential) equation for the covariance matrix of the optimal estimation error. From the solution of the equation for the covariance matrix we obtain the coefficients characterizing the optimal linear filter [36]. The following is a simplified derivation described previously in the references [37, 38].
The initial state,
Thus
The correlation matrix,
The correlation matrix is the expected value of the matrix
Consider a plant which we cannot model accurately using only a deterministic model, because of the presence of uncertainties called process noise and measurement noise:
In the linear, time-varying state-space representation above,
Since we cannot predict the state-vector,
Since the state-vector,
If T < t, this is a data-smoothing (interpolation) problem. If T = t, this is called filtering. If T > t, we have a prediction problem. Since the original treatment is general enough, the collective term estimation is used [36].
Hence, the best estimate to obtain for
Taking in consideration the deviation of the estimated state- vector,
The best estimate of state-vector happens if
The state-equation of the Kalman filter is that of a time-varying observer, and can be written as follows:
If we substitute Eq. (4) into Eq. (12) we get:
Substituting Eq. (13) into Eq. (7)
Here
Using Eqs. (6) and (7), we obtain:
Eq. (16) is the error covariance update equation, where
The trace of the error covariance matrix is the sum of the mean squared errors. The mean squared error may be reduced by minimizing the trace of
We rewrite Eq. (16);
Taking the trace of this expression gives:
Then, we differentiate with respect to
Setting to zero and solving for
Substitution of Eq. (20) into [17], gives:
Eq. (21) is the update equation for the error covariance matrix with optimal gain.
State projection is derived using;
To project the error covariance matrix into the next time interval, k + 1 we first find an expression for the error based on the prior error;
Eq. (7) in time k + 1 is;
Assuming that
This completes the description of the filter.
An algorithm loop is required to make the program in MATLAB and in C-code for the microprocessor. The loop is summarized in the Figure 1.
Recursive algorithm for the Kalman filter.
The KF assumes that the system model is linear and known, the system and measurement noises are white, and the states have initial conditions with known means and variances. The power spectral densities used can be treated as tuning parameters to design an observer with excellent performance and robustness. The linear Kalman filter can also be used to design observers for nonlinear plants, by treating nonlinearities as process noise with appropriate power spectral density matrix.
Since the Kalman filter is an optimal observer the appearance of matrix Riccati equation is not surprising. We are interested in a steady Kalman filter, i.e. the Kalman filter for which the covariance matrix converges to a constant in the limit
From the projections into
Using Eq. 30 in Eqs. 31 and 32 we get:
Rewriting Eq. 34 we get:
When in steady state:
Then we arrive at the Riccati equation:
The iterative solution of the Riccati equation is not required in real time. The observer gain is calculated off-line for predictive control applications [40]. Riccati equations are mainly used to control large scale systems, estimation, and, detection processes.
In this work the discrete-time algebraic Riccati equation (DARE) was solved to obtain the covariance matrix P of the Kalman gain. The discrete-time algebraic Riccati equation is represented by the next form [41]:
Where
Eq. (38) can be written in the short form:
Where:
The application of the Kalman filter implies solving the DARE, which can be solved by several solution methods. Computational methods to solve Riccati equations can be categorized into three classes: invariant subspace methods, deflating subspace methods, and Newton’s methods. The generalized Schur method that is classified as a deflating subspace method is used to solve DARE. The generalized Schur algorithm is a strong algebraic tool that allows computing classical decompositions of matrices, such as the QR and LU factorizations [42]. The next algorithm was used to solve DARE [43]:
Input arguments:
Output arguments:
Form the pencil
Transform the pencil
Using an orthogonal transformation and reorder the generalized real Schur form. So that all the pencil
Form the matrix:
Resistive temperature detectors (RTD) have attracted attention to be employed as thermal health monitors. As clinical thermometers they are stable and reliable presenting high accuracy and resolution [44]. One of the most widely used RTD is the emerging thin-film resistor which has minimal impact on complex circuits due to its small size and due to their negligible mass.
The basic function of the sensor is determined by a proportional increment of resistance when temperature is applied. RTDs can be employed on a rigid or flexible substrate [45, 46, 47], the metal combination with a flexible o rigid substrate can cover conformal applications. RTD fabrication can be done by metals like Pt [48, 49, 50], Cu [51], Ag [52], and Ni [53], among other materials. Nickel presents a suitable option for RTD fabrication due to its wide temperature linear range of operation and its relatively low price.
Clinical thermometers require a high definition and reliability because less than 1°C difference can indicate a health problem. The thermometer signal can be amplified by electronic means, but it is desirable to filter such readings. This work is focused to the filtering and prediction of an highly sensitive Nickel based thin film RTD (range, 273–325 K), to be incorporated to complex circuits [54], we present the theoretical analysis about the relation sensibility-resistance that matches with experimental results.
All metals produce an increase in its resistance to an increase in specific temperature, which means that resistance is linearly proportional to temperature change. This dependence between electrical resistance and temperature is the principle of operation used by a resistance temperature detector (RTD). The relation between temperature-resistance for Pt wire (RTD), is described by the equation known as the Calendar-Van Dusen, Eq. 41) [50].
Where R0°C is the resistance at 0°C, α and β are temperature coefficients and T is temperature, the temperature coefficients depend only on material properties. In addition, the RTD resistance depends on its geometrical design, according to Eq. 42.
Where “σ” is the resistivity, “L” length, “A” lateral area, “w” channel width, and “t” channel height. Only by increasing the length “L” or decreasing the area “A” that means reducing the “t” film thickness or the “w” channel wide, the resistance can increase.
The estimation of the thermal system is represented by the linear stochastic state-space description
Generally, the RTD system is modeled as an RLC circuit, which consists of a resistor a capacitor and an inductor in series with an input voltage. The output that we analyzed is the voltage across the resistor which is related to temperature change. The RLC circuit is represented by a second-order differential equation
Also, we may simplify the response of the system to that of a first-order RC circuit. This implies to solve a first-order ordinary differential equation:
In this work, a Kalman Filter is proposed to decrease the time response to improve the speed feedback and filtering of the perturbations by signal noise from physical signals as thermal detectors. In some instances, a reduced model is advisable to use in an embedded system due to easy implementation and low computational complexity [2].
Kalman filter can be embedded in a temperature system made by Resistance Thermal Detectors (RTD).RTD’s are robust elements that require relatively easy measurement, as a consequence are a useful thermal sensor for industry and medical applications. Nevertheless, these devices are exposing to vibration, electrical noise, and measurement errors generated by the thermoelectric effect caused by the temperature difference between electrical contacts, which affects the response time of the sensor. The implementation of the Kalman filter in a temperature system produces an optimal estimative of thermal behavior and decreases the uncertainties about the prediction of the temperature.
In order to describe the system in the state space, it is necessary to apply system identification methods using MATLAB. Then, after obtaining the system’s state space model we are able to use the Kalman filter algorithm to estimate the future output of the system.
To study the dynamics of our system, we used MATLAB functions
Using MATLAB we are able to acquire the Discrete-time identified state-space model:
with:
Estimated using
System ID using MATLAB. Input output model for a step response defined problem.
Bode diagram indicating the system is a second order system as described by the system transfer function.
Systems model and measured evolutions in time. Fit to estimation data: 90.27%.
We modify the MATLAB example for the time-varying case found in [55] and we code our own function to solve the Discrete Algebraic Riccati Equation. MATLAB functions like predict or forecast were found useful to understand the problem at hand, however they were not used in the code we present here.
w(1:n) = sqrt(Q)*randn(n,1);
v(1:n) = sqrt(R)*randn(n,1);
systv = ss(A,B,C,0,Ts);
ytv(1:n) = lsim(systv,U(1:n) + w(1:n)).
yvtv(1:n) = ytv(1:n) + v(1:n);
Ptv(:,:) = B(:,:)*Q*B(:,:)’; % Initial error covariance.
x = zeros(order,1); % Initial condition on the state.
order = 2;
yetv(1:n) = zeros(n,1);
ycov(1:n) = zeros(n,1);
for i = 1:n.
% Measurement update.
Mn(:,:) = Ptv(:,:)*C(:,:)’/(C(:,:)*Ptv(:,:)*C(:,:)’ + R);
x = x + Mn(:,:)*(yvtv(i)-C(:,:)*x); % x[n|n].
Ptv(:,:) = (eye(order)-Mn(:,:)*C(:,:))*Ptv(:,:); % P[n|n].
yetv(i) = C(:,:)*x;
errcov(i) = C(:,:)*Ptv(:,:)*C(:,:)’;
% Time update.
x = A(:,:)*x + B(:,:)*U(i); % x[n + 1|n].
Ptv(:,:) = A(:,:)*Ptv(:,:)*A(:,:)’ + B(:,:)*Q*B(:,:)’; P[n + 1|n].
end
%% DARE. We coded our own dare function [X,L,G] = sdare(A,B,Q,R).
[P_inf,L,M_inf] = sdare(atv,ctv’,Q,R);
for i = 1:p
% Measurement update.
x = x + M_inf’*(yvtv(i)-ctv*x); % x[n|n].
yetv_inf(i) = ctv*x;
errcov_inf(i) = ctv*P_inf*ctv’;
% Time update.
x = atv*x + btv*U(i); % x[n + 1|n].
P_inf = atv*P_inf*atv’ + btv*Q*btv’; % P[n + 1|n].
end
function [SD] = sdare(A,B,Q,R).
At = transpose(A);
Bt = transpose(B);
S1 = size(A);
E = eye(S1);
Z = zeros(S1);
Ri = inv.(R);
S = B*Ri*Bt;
Pdare = [A Z; −Q E];
Ndare = [E S; Z At];
[AA,BB,L,Z] = qz(Pdare,Ndare);
[AAS1,BBS1,QS1,ZS1] = ordqz(AA,BB,L,Z,‘udi’);
O = ZS1(1:2,1:2);
P = ZS1(3:4,1:2);
H = inv.(O);
SD = P*H;
end
Matlab was used to simulate the response of an RTD modelled as a second order system. In Figure 5(A) we show the plot of the true response y (cyan line) and the filtered response (red line). In Figure 5(B) the plot compares the measurement error with the estimation error. As can be seen in Figure 5(C) the time-varying filter also estimates the covariance errcov of the estimation error at each sample which shows when the filter reached steady state. As it can be seen, we have the possibility to predict the state after approximately 8 seconds. Also, we show the evolution of the estimated temperature response showing an error of −0.0948°C in the best of the cases and less than 1°C in the worst of the cases after 45 seconds.
(A) Evolution of the estimated temperature response showing an error of −0.0948°C in the best of the cases and less than 1°C in the worst of the cases. (B) Evolution of the measurement and estimation errors. (C) Evolution of the covariance of the error showing the possibility to predict the state after approximately 8 seconds.
The unit step response depends on the roots of the characteristic equation. If both roots are real-valued, the second-order system behaves like a chain of two first-order systems, and the step response has two exponential components. If the roots are complex, the step response is a harmonic oscillation with an exponentially decaying amplitude [56]. In our case, the roots of the characteristic polynomial:
The state description for an RC system is described above. From there, we know that the dynamics are dependent only on the RC constant. In addition, there is an amplificator in the system electronics that has a gain of 260. To solve for the RC constant of the system we use the least-squares method (Chi square minimization). The system has a solution of the form
Which is a linear equation. Using a linear fitting program:
We obtain
readings[readIndex] = analogRead(inputPin); // read from the sensor.
total = total + readings[readIndex]; // add the reading to the total.
readIndex = readIndex +1; // advance to the next position in the array.
time_equis_readings[time_equis_readIndex] = time_equis_readIndex;
time_equis_readIndex = time_equis_readIndex +1;
if (readIndex > = numReadings) // if we’re at the end of the array.
{
for(i = 0;i < =numReadings-1;i++).
{
Y[i] = log(readings[i]);
time1[i] = time_equis_readings[i];
sumx = (sumx +time_equis_readings[i]);
sumx2 = (sumx2 + time_equis_readings[i]*time_equis_readings[i]);
sumy = (sumy +Y[i]);
sumxy = (sumxy +time_equis_readings[i]*Y[i]);
}
den = (numReadings*sumx2-sumx*sumx);
a = (sumx2*sumy -sumx*sumxy)/den;
Bc = (n*sumxy-sumx*sumy)/den;
// State description.
A = -Bc;B=Bc;C = 260;D = 0;
//wrap around to the beginning:
readIndex = 0;time_equis_readIndex = 0;
}
// KALMAN.
errcov = C*P*C;
for(i = 0;i < =numReadings-1;i++).
{
Mn = P*C/((C*P*C + R)); // initial estimate.
X = X + Mn*(readings[i]-C*X); // update estimate Average_readings[i].
P = (1-Mn*C)*P; // update covariance.
y_e[i] = C*X;
errcov = C*P*C;
X = A*X + B*U; // project into k + 1.
P = A*P*A + B*Q*B; // project into k + 1.
}
timer0_millis = millis();
// Solution to the Riccati equation.
F = -Bc;H = 260;
SQ = sqrt((H*H*Q*R) + (F*F*R*R));
SR = F * R;
P_inf = (SQ + SR)/(H*H);
M_inf = P_inf*C/(C*P_inf*C + R);
for(i = 0;i < =numReadings-1;i++).
{
// Measurement update.
// M_inf;
x_inf = x_inf + M_inf*(readings[i]-C*x_inf); // % x[n|n].
//P_inf; % P[n|n].
y_e_inf = C*x_inf;
errcov_inf = C*P_inf*C;
// Time update.
x_inf = A*x_inf + B*U;
P_inf = A*P_inf*A + B*Q*B;
}
}
The experiments were performed in a thermal bath giving step responses to the desired setup temperature. Figure 6 depicts the upward and downward evolution of the temperature, the Kalman filter and the two predictors (using two different Q and R settings). As can be seen the predictors follow the Temperature of the sensor closely, especially for the upward way, while the Kalman filter lags behind.
Implemented system. Step response for the upwards and downwards evolution. Two different Kalman filters were used to predict (by solving the DARE equation) the evolution of the future state with different Q and R to calibrate the desired response. In blue the evolution of the RTD sensor analog input, in Yellow and red the two Kalman predictors and the Kalman estimation in cyan color.
Sliding control [57] is an additional tool to predict the behavior of a second order system basically smoothing the system by boundary layers. The prediction of the system state trajectory is given using an uncertain model of the system. The subspace which represents the quantity of uncertainties in the prediction process, forces the estimate state trajectory to switching gain to converge the estimates to within a boundary of the real state values. To predict the state trajectory of our RLC system it’s possible to switch its gain by the subspace represented by a first-order RC model. The estimated state trajectory is forced to keep a switch back and forth within the boundary layer represented in our case by a RC model. By creating a boundary layer, the system is further constrained to have a solution existing in between two RC model solutions.
In Figure 7 it can be clearly seen that the use of two estimators may help predict the behavior of the RTD in a much better way. The system needs to be calibrated first in order to have the two Kalman filters enveloping the required solution. As can be seen in the upward direction, both predictors (yellow and red) envelope the desired response (blue), that of the RTD sensor improving the response of the Kalman filter without boundaries (cyan). Unfortunately, this is not the case in the downward evolution. From the nonlinear control systems point of view these two evolutions demark a region where the RTD stands thus making possible to program a better estimator. It is left as an outlook to program a third estimator using this boundary layer in order to have a better predictor, especially for the downward evolution.
Ascending and descending step responses of the Kalman filter and two Predictors which function in real time. In blue the RTD sensor response, in cyan the estimator response, in yellow and in red the two differently calibrated Kalman predictors.
As it can be shown the implementation of the Kalman filter brings the opportunity to estimate the forecast in real time of a second order system using first, MATLAB and second that of two first order systems using a simple RC system coded in C-language for a microprocessor. It has been shown that the program is able to predict the evolution of temperature for a RTD system. Even if the system is implemented using a first order system we can find evolving solutions for our estimation and prediction to be good enough. We predict the state after approximately 8 seconds showing an error of −0.0948°C in the best of the cases. In addition, a boundary layer may be programmed using two first order Kalman predictors which may be tuned by setting Q and R properly. We believe this is the first report on the use of a Kalman filter to predict the evolution of temperature from a RTD.
Book - collection of Works distributed in a book format, whose selection, coordination, preparation, and arrangement has been performed and published by IntechOpen, and in which the Work is included in its entirety in an unmodified form along with one or more other contributions, each constituting separate and independent sections, but together assembled into a collective whole.
",metaTitle:"Attribution Policy",metaDescription:"DEFINITION OF TERMS",metaKeywords:null,canonicalURL:"/page/attribution-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"Work - a book Chapter (as well as Conference Papers), including any and all content, graphics, images and/or other materials forming part of, or accompanying, the Chapter/Conference Paper.
\\n\\nAttribution – appropriate credit for the used Work or book.
\\n\\nCreative Commons licenses – enable licensors to retain copyright while allowing others to use their Works in an appropriate way.
\\n\\nWith the purpose of protecting Authors' copyright and the transparent reuse of OA (Open Access) content, IntechOpen has developed Rules of Attribution of Works licensed under Creative Commons licenses.
\\n\\nIn case you reuse or republish any of the Works licensed under CC licenses, you must abide by the guidelines outlined below:
\\n\\nAll rights to Books and other compilations published on the IntechOpen platform and in print are reserved by IntechOpen. The Copyright to Books and other compilations is subject to a separate Copyright from any that exists in the included Works.
\\n\\nA Book in its entirety or a significant part of a Book cannot be translated freely without specific written consent by the publisher. Further information can be obtained at permissions@intechopen.com.
\\n\\nIn instances where permission is obtained from the publisher for reusing or republishing the Book, or significant parts of the Book, all of the following conditions apply:
\\n\\nEvery single Work that is used has to be attributed in the way described. If you are unsure about proper attribution, please write to permissions@intechopen.com.
\\n\\nIndividual Works originally published in IntechOpen books are licensed under Creative Commons licenses and can be freely used under terms of the respective CC license, if properly attributed. In order to properly attribute the Work you must respect all the conditions outlined below:
\\n\\nEvery single Work that is used has to be attributed in the way as described. If you are unsure about proper attribution, please contact Us at permissions@intechopen.com.
\\n\\nIn the event that you use more than one of IntechOpen's Works published in one or more books (but not a significant part of the book that is under separate Copyright), each of these have to be properly attributed in the way described.
\\n\\nIntechOpen does not have any claims on newly created copyrighted Works, but the Works originally published by IntechOpen must be properly attributed.
\\n\\nAll these rules apply to BOTH online and offline use.
\\n\\nParts of the Rules of Attribution are based on Work Attributing Creative Commons Materials published by the Australian Research Council Centre of Excellence for Creative Industries and Innovation, in partnership with Creative Commons Australia, which can be found at creativecommons.org.au licensed under Creative Commons Attribution 2.5 Australia license, and Best practices for attribution published by Creative Commons, which can be found at wiki.creativecommons.org under the Creative Commons Attribution 4.0 license.
\\n\\nAll the above rules are subject to change, IntechOpen reserves the right to take appropriate action if any of the conditions outlined above are not met.
\\n\\nPolicy last updated: 2016-06-09
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Work - a book Chapter (as well as Conference Papers), including any and all content, graphics, images and/or other materials forming part of, or accompanying, the Chapter/Conference Paper.
\n\nAttribution – appropriate credit for the used Work or book.
\n\nCreative Commons licenses – enable licensors to retain copyright while allowing others to use their Works in an appropriate way.
\n\nWith the purpose of protecting Authors' copyright and the transparent reuse of OA (Open Access) content, IntechOpen has developed Rules of Attribution of Works licensed under Creative Commons licenses.
\n\nIn case you reuse or republish any of the Works licensed under CC licenses, you must abide by the guidelines outlined below:
\n\nAll rights to Books and other compilations published on the IntechOpen platform and in print are reserved by IntechOpen. The Copyright to Books and other compilations is subject to a separate Copyright from any that exists in the included Works.
\n\nA Book in its entirety or a significant part of a Book cannot be translated freely without specific written consent by the publisher. Further information can be obtained at permissions@intechopen.com.
\n\nIn instances where permission is obtained from the publisher for reusing or republishing the Book, or significant parts of the Book, all of the following conditions apply:
\n\nEvery single Work that is used has to be attributed in the way described. If you are unsure about proper attribution, please write to permissions@intechopen.com.
\n\nIndividual Works originally published in IntechOpen books are licensed under Creative Commons licenses and can be freely used under terms of the respective CC license, if properly attributed. In order to properly attribute the Work you must respect all the conditions outlined below:
\n\nEvery single Work that is used has to be attributed in the way as described. If you are unsure about proper attribution, please contact Us at permissions@intechopen.com.
\n\nIn the event that you use more than one of IntechOpen's Works published in one or more books (but not a significant part of the book that is under separate Copyright), each of these have to be properly attributed in the way described.
\n\nIntechOpen does not have any claims on newly created copyrighted Works, but the Works originally published by IntechOpen must be properly attributed.
\n\nAll these rules apply to BOTH online and offline use.
\n\nParts of the Rules of Attribution are based on Work Attributing Creative Commons Materials published by the Australian Research Council Centre of Excellence for Creative Industries and Innovation, in partnership with Creative Commons Australia, which can be found at creativecommons.org.au licensed under Creative Commons Attribution 2.5 Australia license, and Best practices for attribution published by Creative Commons, which can be found at wiki.creativecommons.org under the Creative Commons Attribution 4.0 license.
\n\nAll the above rules are subject to change, IntechOpen reserves the right to take appropriate action if any of the conditions outlined above are not met.
\n\nPolicy last updated: 2016-06-09
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11661},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33642}],offset:12,limit:12,total:135275},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{sort:"dateEndThirdStepPublish"},books:[{type:"book",id:"11632",title:"Updated Research on Bacteriophages",subtitle:null,isOpenForSubmission:!0,hash:"d34dfa0d5d10511184f97ddaeef9936b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11632.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11616",title:"Foraging",subtitle:null,isOpenForSubmission:!0,hash:"955b60bb658c8d1a09dd4efc9bf6674b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11616.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11697",title:"Scoliosis",subtitle:null,isOpenForSubmission:!0,hash:"fa052443744b8f6ba5a87091e373bafe",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11697.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11699",title:"Neonatal Surgery",subtitle:null,isOpenForSubmission:!0,hash:"e52adaee8e54f51c2ba4972daeb410f7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11699.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11730",title:"Midwifery",subtitle:null,isOpenForSubmission:!0,hash:"95389fcd878d0e929234c441744ba398",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11730.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11369",title:"RNA Viruses Infection",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11794",title:"Coconut Cultivation",subtitle:null,isOpenForSubmission:!0,hash:"48e1cb42a4162f64cae3a2e777472f21",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11794.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11773",title:"Archaeology - Challenges and Updates",subtitle:null,isOpenForSubmission:!0,hash:"17d91462fa926279f65164ac0d5641cd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11773.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11797",title:"Clostridium difficile",subtitle:null,isOpenForSubmission:!0,hash:"4cb066b44bb8d4a8b93a627de26e3ebf",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11797.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11858",title:"Terahertz Radiation",subtitle:null,isOpenForSubmission:!0,hash:"f08ee0bf20cd8b5fa772b4752081f2fe",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11858.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11776",title:"Fashion Industry",subtitle:null,isOpenForSubmission:!0,hash:"e8d53d1029a7bccf825aa55d43fecc68",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11776.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11809",title:"Lagomorpha",subtitle:null,isOpenForSubmission:!0,hash:"1e8fd5779205c16e5797b05455dc5be0",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11809.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:26},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:7},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:16},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:41},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:16},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:66},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:6},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:489},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3737",title:"MATLAB",subtitle:"Modelling, Programming and Simulations",isOpenForSubmission:!1,hash:null,slug:"matlab-modelling-programming-and-simulations",bookSignature:"Emilson Pereira Leite",coverURL:"https://cdn.intechopen.com/books/images_new/3737.jpg",editors:[{id:"12051",title:"Prof.",name:"Emilson",middleName:null,surname:"Pereira Leite",slug:"emilson-pereira-leite",fullName:"Emilson Pereira Leite"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"1770",title:"Gel Electrophoresis",subtitle:"Principles and Basics",isOpenForSubmission:!1,hash:"279701f6c802cf02deef45103e0611ff",slug:"gel-electrophoresis-principles-and-basics",bookSignature:"Sameh Magdeldin",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4797},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7175,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1981,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2308,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1473,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318571,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271836,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",publishedDate:"July 1st 2013",numberOfDownloads:243450,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1582,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2082,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",publishedDate:"October 17th 2012",numberOfDownloads:256294,editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1322",title:"Inequality",slug:"inequality",parent:{id:"268",title:"Gender Studies",slug:"gender-studies"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:18,numberOfWosCitations:34,numberOfCrossrefCitations:26,numberOfDimensionsCitations:47,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1322",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"5472",title:"Gender Differences in Different Contexts",subtitle:null,isOpenForSubmission:!1,hash:"2f67b9514d1d24a468b8cdf15f0c1cdb",slug:"gender-differences-in-different-contexts",bookSignature:"Aida Alvinius",coverURL:"https://cdn.intechopen.com/books/images_new/5472.jpg",editedByType:"Edited by",editors:[{id:"145558",title:"Associate Prof.",name:"Aida",middleName:null,surname:"Alvinius",slug:"aida-alvinius",fullName:"Aida Alvinius"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"52349",doi:"10.5772/65287",title:"Gender Differences in PTSD: Susceptibility and Resilience",slug:"gender-differences-in-ptsd-susceptibility-and-resilience",totalDownloads:2710,totalCrossrefCites:12,totalDimensionsCites:20,abstract:"Posttraumatic stress disorder (PTSD) is anxiety disorder that has been estimated to affect individuals who are exposed to traumatic events. Women are diagnosed with PTSD approximately twice as often as men. In this review, we outline the evidence of gender differences related to PTSD, and the factors of resilience and susceptibility differ between men and women.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Jingchu Hu, Biao Feng, Yonghui Zhu, Wenqing Wang, Jiawei Xie\nand Xifu Zheng",authors:[{id:"190985",title:"Dr.",name:"Xifu",middleName:null,surname:"Zheng",slug:"xifu-zheng",fullName:"Xifu Zheng"},{id:"194981",title:"BSc.",name:"Yonghui",middleName:null,surname:"Zhu",slug:"yonghui-zhu",fullName:"Yonghui Zhu"},{id:"194982",title:"MSc.",name:"Wenqing",middleName:null,surname:"Wang",slug:"wenqing-wang",fullName:"Wenqing Wang"},{id:"194985",title:"Dr.",name:"Jingchu",middleName:null,surname:"Hu",slug:"jingchu-hu",fullName:"Jingchu Hu"},{id:"194986",title:"MSc.",name:"Biao",middleName:null,surname:"Feng",slug:"biao-feng",fullName:"Biao Feng"},{id:"194987",title:"Ph.D. Student",name:"Jiawei",middleName:null,surname:"Xie",slug:"jiawei-xie",fullName:"Jiawei Xie"}]},{id:"52472",doi:"10.5772/65410",title:"Gender and Health",slug:"gender-and-health",totalDownloads:3432,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Research has found differences between women and men in some health indicators. Women’s life expectancy is higher than men’s, but research on differences in morbidity has proved less consistent than on the differences in mortality. These differences vary in terms of the type of health indicator used, the life cycle period analyzed, and even the country where research is conducted. Generally, men have more life-threatening chronic diseases at younger ages, including coronary heart disease, as well as more externalizing mental health problems and substance use disorders. Women present higher rates of chronic debilitating conditions such as arthritis, frequent or severe headaches, gallbladder conditions, and also more internalizing mental problems such as affective and anxiety disorders. Results of research on the differences between women and men in self-rated health have also highlighted the complexity of gender differences in health. Although several studies have shown that women have poorer self-rated health than men, this is not the case in all countries. Also, differences in self-rated health vary depending on other psychosocial and demographic variables. The present study reviews the main differences in women’s and men’s health as well as the most relevant factors that may account for them.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"María Pilar Matud",authors:[{id:"189729",title:"Prof.",name:"M. Pilar",middleName:null,surname:"Matud",slug:"m.-pilar-matud",fullName:"M. Pilar Matud"}]},{id:"52503",doi:"10.5772/65457",title:"Gender and Leadership",slug:"gender-and-leadership",totalDownloads:4127,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"The topic of leadership has been addressed and applied for millennia. Yet, it is only within the past 80 years that leadership has been a topic of serious discussion. It is important to understand variables relevant to effective leadership. Gender is one such variable that must be examined with regard to optimizing leadership effectiveness. The topic of gender and leadership deserves serious and thoughtful consideration and discussion because of professional, political, cultural, and personal realities of the twenty‐first century. Women and men have been, are, and should be leaders. Gender must be considered to determine how each leader can reach maximum potential and effectiveness. The FourCe‐PITO conceptual framework of leadership is designed to help guide leadership development and education. The present chapter uses this conceptual framework of leadership to discuss how consideration of gender may affect and optimize leadership development and effectiveness. It is the goal of this chapter to lay out the issues that educators of leaders, potential leaders, and “practicing” leaders should be aware of, to achieve success for the good of the groups and individuals they have the responsibility to lead.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Kathryn E. Eklund, Erin S. Barry and Neil E. Grunberg",authors:[{id:"191531",title:"Dr.",name:"Neil E.",middleName:null,surname:"Grunberg",slug:"neil-e.-grunberg",fullName:"Neil E. Grunberg"},{id:"191532",title:"Dr.",name:"Erin S.",middleName:null,surname:"Barry",slug:"erin-s.-barry",fullName:"Erin S. Barry"},{id:"191533",title:"Ph.D. Student",name:"Kathryn",middleName:null,surname:"Eklund",slug:"kathryn-eklund",fullName:"Kathryn Eklund"}]},{id:"53190",doi:"10.5772/66433",title:"Sex Differences as a Statistical Variable",slug:"sex-differences-as-a-statistical-variable",totalDownloads:1805,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Gender differences are often seen as either biologically determined or culturally acquired or conditioned. However, in an age where gender equality is the main target, neither peer reviewers nor students show much interest in gender differences. Moreover, not only do people try to integrate their ‘ying’ and ‘yang’ in their personalities also transgender identities are publicly acknowledged, appreciated and respected. Thus, in this chapter, I argue that we need to downgrade gender differences to a statistical variable that explains variance, sharpens statistical effects and reveals strategies. I am giving examples from my developmental psychology research where the split-sample analysis by gender showed amazing and often unexpected effects.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Chris Lange-Küttner",authors:[{id:"190245",title:"Prof.",name:"Chris",middleName:null,surname:"Lange-Küttner",slug:"chris-lange-kuttner",fullName:"Chris Lange-Küttner"}]},{id:"53721",doi:"10.5772/66093",title:"Professional Women's Experience of Autonomy and Independence in Sindh-Pakistan",slug:"professional-women-s-experience-of-autonomy-and-independence-in-sindh-pakistan",totalDownloads:1644,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"This chapter summarises the part of findings of my doctoral studies at the University of Sussex, Brighton, UK. In this case study, there are elements of both qualitative and quantitative approaches; the former is the principal approach to this research while the latter works as complementary. Participants of the research were divided into two categories: academic and non‐academic. Forty semi‐structured interviews (20 from each category) and 100 survey questionnaire (50 from each category) were collected. This research argues that existing concepts of ‘autonomy’ and ‘independence’ may not be useful indices/indicators for measuring the social status or position of women in Sindhi society, due to variations in understanding or the meanings attributed to these concepts across the globe. Findings argue that these professional women perceived concepts of ‘autonomy’, ‘independence’ and ‘individuality’ categorically different than those of Westernised understandings. This research asserts that Sindhi society, similarly to that of Tamil society, emphasises social groups rather than individuals. Hence, ‘collective identities’ are the essence of Sindhi society; however, individuals find their autonomy, independence and individuality in the context of ‘others’, which means to be more responsible for group's interests.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Mukesh Kumar Khatwani",authors:[{id:"196384",title:"Dr.",name:"Mukesh",middleName:"Kumar",surname:"Khatwani",slug:"mukesh-khatwani",fullName:"Mukesh Khatwani"}]}],mostDownloadedChaptersLast30Days:[{id:"52503",title:"Gender and Leadership",slug:"gender-and-leadership",totalDownloads:4125,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"The topic of leadership has been addressed and applied for millennia. Yet, it is only within the past 80 years that leadership has been a topic of serious discussion. It is important to understand variables relevant to effective leadership. Gender is one such variable that must be examined with regard to optimizing leadership effectiveness. The topic of gender and leadership deserves serious and thoughtful consideration and discussion because of professional, political, cultural, and personal realities of the twenty‐first century. Women and men have been, are, and should be leaders. Gender must be considered to determine how each leader can reach maximum potential and effectiveness. The FourCe‐PITO conceptual framework of leadership is designed to help guide leadership development and education. The present chapter uses this conceptual framework of leadership to discuss how consideration of gender may affect and optimize leadership development and effectiveness. It is the goal of this chapter to lay out the issues that educators of leaders, potential leaders, and “practicing” leaders should be aware of, to achieve success for the good of the groups and individuals they have the responsibility to lead.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Kathryn E. Eklund, Erin S. Barry and Neil E. Grunberg",authors:[{id:"191531",title:"Dr.",name:"Neil E.",middleName:null,surname:"Grunberg",slug:"neil-e.-grunberg",fullName:"Neil E. Grunberg"},{id:"191532",title:"Dr.",name:"Erin S.",middleName:null,surname:"Barry",slug:"erin-s.-barry",fullName:"Erin S. Barry"},{id:"191533",title:"Ph.D. Student",name:"Kathryn",middleName:null,surname:"Eklund",slug:"kathryn-eklund",fullName:"Kathryn Eklund"}]},{id:"52349",title:"Gender Differences in PTSD: Susceptibility and Resilience",slug:"gender-differences-in-ptsd-susceptibility-and-resilience",totalDownloads:2708,totalCrossrefCites:12,totalDimensionsCites:20,abstract:"Posttraumatic stress disorder (PTSD) is anxiety disorder that has been estimated to affect individuals who are exposed to traumatic events. Women are diagnosed with PTSD approximately twice as often as men. In this review, we outline the evidence of gender differences related to PTSD, and the factors of resilience and susceptibility differ between men and women.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Jingchu Hu, Biao Feng, Yonghui Zhu, Wenqing Wang, Jiawei Xie\nand Xifu Zheng",authors:[{id:"190985",title:"Dr.",name:"Xifu",middleName:null,surname:"Zheng",slug:"xifu-zheng",fullName:"Xifu Zheng"},{id:"194981",title:"BSc.",name:"Yonghui",middleName:null,surname:"Zhu",slug:"yonghui-zhu",fullName:"Yonghui Zhu"},{id:"194982",title:"MSc.",name:"Wenqing",middleName:null,surname:"Wang",slug:"wenqing-wang",fullName:"Wenqing Wang"},{id:"194985",title:"Dr.",name:"Jingchu",middleName:null,surname:"Hu",slug:"jingchu-hu",fullName:"Jingchu Hu"},{id:"194986",title:"MSc.",name:"Biao",middleName:null,surname:"Feng",slug:"biao-feng",fullName:"Biao Feng"},{id:"194987",title:"Ph.D. Student",name:"Jiawei",middleName:null,surname:"Xie",slug:"jiawei-xie",fullName:"Jiawei Xie"}]},{id:"52472",title:"Gender and Health",slug:"gender-and-health",totalDownloads:3430,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Research has found differences between women and men in some health indicators. Women’s life expectancy is higher than men’s, but research on differences in morbidity has proved less consistent than on the differences in mortality. These differences vary in terms of the type of health indicator used, the life cycle period analyzed, and even the country where research is conducted. Generally, men have more life-threatening chronic diseases at younger ages, including coronary heart disease, as well as more externalizing mental health problems and substance use disorders. Women present higher rates of chronic debilitating conditions such as arthritis, frequent or severe headaches, gallbladder conditions, and also more internalizing mental problems such as affective and anxiety disorders. Results of research on the differences between women and men in self-rated health have also highlighted the complexity of gender differences in health. Although several studies have shown that women have poorer self-rated health than men, this is not the case in all countries. Also, differences in self-rated health vary depending on other psychosocial and demographic variables. The present study reviews the main differences in women’s and men’s health as well as the most relevant factors that may account for them.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"María Pilar Matud",authors:[{id:"189729",title:"Prof.",name:"M. Pilar",middleName:null,surname:"Matud",slug:"m.-pilar-matud",fullName:"M. Pilar Matud"}]},{id:"53212",title:"Broken Dreams—Balancing Self and Family Well-Being: The Experiences of Women Immigrants to Hamilton, ON",slug:"broken-dreams-balancing-self-and-family-well-being-the-experiences-of-women-immigrants-to-hamilton-o",totalDownloads:1512,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter presents the preliminary analysis of a study conducted in Hamilton, ON. It explores the intersection of women’s immigration, integration and mental health. Their perceptions of what is needed from them in relation to the various challenges/changes that moving to a new country entails is a particular focus of this research. To begin with, the term “women immigrant” (WI) is used, rather than immigrant women as commonly used—as the participants were women long before they became immigrants. Indeed immigration is one of their many experiences and it is a significant marker in their lives, but it does not define their identity.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Mirna Carranza",authors:[{id:"189735",title:"Dr.",name:"Mirna",middleName:null,surname:"Carranza",slug:"mirna-carranza",fullName:"Mirna Carranza"}]},{id:"52314",title:"Gender Difference in the Perception of Guilt in Consumer Boycott in Brazil",slug:"gender-difference-in-the-perception-of-guilt-in-consumer-boycott-in-brazil",totalDownloads:1804,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The aim of this chapter is to analyze consumer boycott from the perception of men's and women's guilt on a specific case involving Nike company through partners in its supply chain in China. The study was conducted with 281 consumers in the city of Rio de Janeiro (Brazil) in 2012. In the process of validating a scale of consumer boycott in Brazil, the 13 items of the original scale were kept, but were grouped in different factors. The emerged factors were perception of guilt, influence from others, boycott efficiency, and purchase frequency. Testing relationship among demographic variables and these factors, only gender was significant on perception of guilt. In this sense, we seek in psychology, psychoanalysis (also briefly in anthropology and history), features that could explain the reasons why women feel guiltier than men, and thus are more likely to boycott.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Breno de P.A. Cruz, Ricardo José Marques Pires-Jr. and Steven D. Ross",authors:[{id:"189599",title:"Associate Prof.",name:"Breno",middleName:"De Paula Andrade",surname:"Cruz",slug:"breno-cruz",fullName:"Breno Cruz"},{id:"189600",title:"Mr.",name:"Ricardo",middleName:"José Marques",surname:"Pires-Júnior",slug:"ricardo-pires-junior",fullName:"Ricardo Pires-Júnior"},{id:"189601",title:"Dr.",name:"Steven",middleName:null,surname:"Dutt Ross",slug:"steven-dutt-ross",fullName:"Steven Dutt Ross"}]}],onlineFirstChaptersFilter:{topicId:"1322",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 12th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,annualVolume:11418,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,annualVolume:11419,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,annualVolume:11421,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,annualVolume:11422,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,annualVolume:11423,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"83065",title:"Interventions and Practical Approaches to Reduce the Burden of Malaria on School-Aged Children",doi:"10.5772/intechopen.106469",signatures:"Andrew Macnab",slug:"interventions-and-practical-approaches-to-reduce-the-burden-of-malaria-on-school-aged-children",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Andrew",surname:"Macnab"}],book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}]},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",biography:"Dr. Kasenga is a graduate of Tumaini University, Kilimanjaro Christian Medical College, Moshi, Tanzania and Umeå University, Sweden. He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). Dr. Kasenga is married to Grace and blessed with three children, a son and two daughters: Happy, Lettice and Sungani.",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 22nd 2022",isOpenForSubmission:!0,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:20,paginationItems:[{id:"83065",title:"Interventions and Practical Approaches to Reduce the Burden of Malaria on School-Aged Children",doi:"10.5772/intechopen.106469",signatures:"Andrew Macnab",slug:"interventions-and-practical-approaches-to-reduce-the-burden-of-malaria-on-school-aged-children",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Andrew",surname:"Macnab"}],book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82559",title:"Perspective Chapter: Bioinformatics Study of the Evolution of SARS-CoV-2 Spike Protein",doi:"10.5772/intechopen.105915",signatures:"Črtomir Podlipnik, Radostina Alexandrova, Sebastian Pleško, Urban Bren and Marko Jukič",slug:"perspective-chapter-bioinformatics-study-of-the-evolution-of-sars-cov-2-spike-protein",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82521",title:"Challenges in Platelet Functions in HIV/AIDS Management",doi:"10.5772/intechopen.105731",signatures:"Gordon Ogweno",slug:"challenges-in-platelet-functions-in-hiv-aids-management",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82701",title:"Pathology of Streptococcal Infections",doi:"10.5772/intechopen.105814",signatures:"Yutaka Tsutsumi",slug:"pathology-of-streptococcal-infections",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yutaka",surname:"Tsutsumi"}],book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82634",title:"Bacterial Sexually Transmitted Disease",doi:"10.5772/intechopen.105747",signatures:"Lebeza Alemu Tenaw",slug:"bacterial-sexually-transmitted-disease",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82552",title:"Perspective Chapter: SARS-CoV-2 Variants - Two Years Post-Onset of the Pandemic",doi:"10.5772/intechopen.105913",signatures:"Adekunle Sanyaolu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Abdul Jan, Priyank Desai, Abu Fahad Abbasi, Jasmine Mangat, Zaheeda Hosein, Kareem Hamdy, Nafees Haider, Nasar Khan, Rochelle Annan, Olanrewaju Badaru, Ricardo Izurieta and Stella Smith",slug:"perspective-chapter-sars-cov-2-variants-two-years-post-onset-of-the-pandemic",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Fungal Infectious Diseases",value:4,count:1,group:"subseries"},{caption:"Parasitic Infectious Diseases",value:5,count:4,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:5,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:10,group:"subseries"}],publishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",publishedDate:"July 27th 2022",editedByType:"Edited by",bookSignature:"Dragana Gabrić and Marko Vuletić",hash:"4af8830e463f89c57515c2da2b9777b0",volumeInSeries:11,fullTitle:"Current Concepts in Dental Implantology - From Science to Clinical Research",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić",profilePictureURL:"https://mts.intechopen.com/storage/users/26946/images/system/26946.png",institutionString:"University of Zagreb",institution:{name:"University of Zagreb",institutionURL:null,country:{name:"Croatia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9493",title:"Periodontology",subtitle:"Fundamentals and Clinical Features",coverURL:"https://cdn.intechopen.com/books/images_new/9493.jpg",slug:"periodontology-fundamentals-and-clinical-features",publishedDate:"February 16th 2022",editedByType:"Edited by",bookSignature:"Petra Surlin",hash:"dfe986c764d6c82ae820c2df5843a866",volumeInSeries:8,fullTitle:"Periodontology - Fundamentals and Clinical Features",editors:[{id:"171921",title:"Prof.",name:"Petra",middleName:null,surname:"Surlin",slug:"petra-surlin",fullName:"Petra Surlin",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:"University of Medicine and Pharmacy of Craiova",institution:{name:"University of Medicine and Pharmacy of Craiova",institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9588",title:"Clinical Concepts and Practical Management Techniques in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9588.jpg",slug:"clinical-concepts-and-practical-management-techniques-in-dentistry",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Aneesa Moolla",hash:"42deab8d3bcf3edf64d1d9028d42efd1",volumeInSeries:7,fullTitle:"Clinical Concepts and Practical Management Techniques in Dentistry",editors:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",institutionURL:null,country:{name:"South Africa"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8202",title:"Periodontal Disease",subtitle:"Diagnostic and Adjunctive Non-surgical Considerations",coverURL:"https://cdn.intechopen.com/books/images_new/8202.jpg",slug:"periodontal-disease-diagnostic-and-adjunctive-non-surgical-considerations",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Nermin Mohammed Ahmed Yussif",hash:"0aee9799da7db2c732be44dd8fed16d8",volumeInSeries:6,fullTitle:"Periodontal Disease - Diagnostic and Adjunctive Non-surgical Considerations",editors:[{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",institutionString:"MSA University",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8837",title:"Human Teeth",subtitle:"Key Skills and Clinical Illustrations",coverURL:"https://cdn.intechopen.com/books/images_new/8837.jpg",slug:"human-teeth-key-skills-and-clinical-illustrations",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Zühre Akarslan and Farid Bourzgui",hash:"ac055c5801032970123e0a196c2e1d32",volumeInSeries:5,fullTitle:"Human Teeth - Key Skills and Clinical Illustrations",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui",profilePictureURL:"https://mts.intechopen.com/storage/users/52177/images/system/52177.png",biography:"Prof. Farid Bourzgui obtained his DMD and his DNSO option in Orthodontics at the School of Dental Medicine, Casablanca Hassan II University, Morocco, in 1995 and 2000, respectively. Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Prosthodontics and Implant Dentistry",value:2,count:3},{group:"subseries",caption:"Oral Health",value:1,count:6}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:303,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"117248",title:"Dr.",name:"Andrew",middleName:null,surname:"Macnab",slug:"andrew-macnab",fullName:"Andrew Macnab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. Gonzalez-Sanchez",slug:"juan-a.-gonzalez-sanchez",fullName:"Juan A. Gonzalez-Sanchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico System",country:{name:"United States of America"}}},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}}]}},subseries:{item:{id:"6",type:"subseries",title:"Viral Infectious Diseases",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11402,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null,series:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188"},editorialBoard:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}},{id:"188219",title:"Prof.",name:"Imran",middleName:null,surname:"Shahid",slug:"imran-shahid",fullName:"Imran Shahid",profilePictureURL:"https://mts.intechopen.com/storage/users/188219/images/system/188219.jpeg",institutionString:null,institution:{name:"Umm al-Qura University",institutionURL:null,country:{name:"Saudi Arabia"}}},{id:"214235",title:"Dr.",name:"Lynn",middleName:"S.",surname:"Zijenah",slug:"lynn-zijenah",fullName:"Lynn Zijenah",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSEJGQA4/Profile_Picture_1636699126852",institutionString:null,institution:{name:"University of Zimbabwe",institutionURL:null,country:{name:"Zimbabwe"}}},{id:"178641",title:"Dr.",name:"Samuel Ikwaras",middleName:null,surname:"Okware",slug:"samuel-ikwaras-okware",fullName:"Samuel Ikwaras Okware",profilePictureURL:"https://mts.intechopen.com/storage/users/178641/images/system/178641.jpg",institutionString:null,institution:{name:"Uganda Christian University",institutionURL:null,country:{name:"Uganda"}}}]},onlineFirstChapters:{paginationCount:10,paginationItems:[{id:"82112",title:"Comparative Senescence and Lifespan",doi:"10.5772/intechopen.105137",signatures:"Hassan M. Heshmati",slug:"comparative-senescence-and-lifespan",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hassan M.",surname:"Heshmati"}],book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:30,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81290",title:"Musculoskeletal Abnormalities Caused by Cystic Fibrosis",doi:"10.5772/intechopen.104591",signatures:"Mark Lambrechts",slug:"musculoskeletal-abnormalities-caused-by-cystic-fibrosis",totalDownloads:29,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81226",title:"Computational Methods for the Study of Peroxisomes in Health and Disease",doi:"10.5772/intechopen.103178",signatures:"Naomi van Wijk and Michal Linial",slug:"computational-methods-for-the-study-of-peroxisomes-in-health-and-disease",totalDownloads:32,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"80326",title:"Anti-Senescence Therapy",doi:"10.5772/intechopen.101585",signatures:"Raghad Alshadidi",slug:"anti-senescence-therapy",totalDownloads:110,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79828",title:"Cellular Senescence in Bone",doi:"10.5772/intechopen.101803",signatures:"Danielle Wang and Haitao Wang",slug:"cellular-senescence-in-bone",totalDownloads:119,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79668",title:"Identification of RNA Species That Bind to the hnRNP A1 in Normal and Senescent Human Fibroblasts",doi:"10.5772/intechopen.101525",signatures:"Heriberto Moran, Shanaz A. Ghandhi, Naoko Shimada and Karen Hubbard",slug:"identification-of-rna-species-that-bind-to-the-hnrnp-a1-in-normal-and-senescent-human-fibroblasts",totalDownloads:81,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79295",title:"Genetic and Epigenetic Influences on Cutaneous Cellular Senescence",doi:"10.5772/intechopen.101152",signatures:"Tapash Jay Sarkar, Maiko Hermsmeier, Jessica L. Ross and G. Scott Herron",slug:"genetic-and-epigenetic-influences-on-cutaneous-cellular-senescence",totalDownloads:135,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}}]},publishedBooks:{paginationCount:4,paginationItems:[{type:"book",id:"10664",title:"Animal Reproduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",slug:"animal-reproduction",publishedDate:"May 25th 2022",editedByType:"Edited by",bookSignature:"Yusuf Bozkurt and Mustafa Numan Bucak",hash:"2d66af42fb17d0a6556bb9ef28e273c7",volumeInSeries:11,fullTitle:"Animal Reproduction",editors:[{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"7",title:"Bioinformatics and Medical Informatics",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine"},{id:"8",title:"Bioinspired Technology and Biomechanics",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation"},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/129677",hash:"",query:{},params:{id:"129677"},fullPath:"/profiles/129677",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()