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Brian Harvey

Royal College of Surgeons in Ireland Ireland

Brian Harvey, Professor of Molecular Medicine, Royal College of Surgeons in Ireland Brian Harvey holds primary degrees in mathematics, physics and a PhD in biophysics from the National University of Ireland. He is Professor of Molecular Medicine at the Royal College of Surgeons in Ireland (www.rcsi.ie/molmed) and research professor at the Université de Paris Descartes and an Investigador at the Centro di Estudios Cientificos CECs Valdivia Chile. He was Ireland’s first and longest serving university vice-president for research from 1998-2010. His academic roles include Head of Department of Molecular Medicine at RCSI, Director of Research of the DOCTRID Research Institute (www.doctrid.ie), coordinator of the EU Marie Curie COFUND in assistive technologies (www.assistid.eu), scientific head of the EU COST Action ADMIRE (www.admirecost.eu) and coordinator of the National Biophotonics & Imaging Platform Ireland (www.nbipireland.ie). His role in promoting Irish biomedical research has been recognized by honours at home and abroad. He was awarded a knighthood (Chevalier) of the French Order of Merit in 2006 by the President of France and awarded the Order of Palmes Academiques by the Prime Minister of France in 2016, and was the recipient of the International Laureat Prix Servier in 2008. In 2000, Brian was elected member of the European Academy of Sciences and in 2007 elected to the Royal Irish Academy. In 2013, he was awarded a Doctor of Science honoris causa from Michigan State University. Brian has served on the European Research Council Advanced Awards Panel 2008-2016 and as president of the French National Research Agency ANR scientific evaluation council 2015-2016. His research specialty is in molecular endocrinology of steroid hormone actions in inflammation and cancer – see https://orcid.org/0000-0002-7388-8034 for publications

1books edited

2chapters authored

Latest work with IntechOpen by Brian Harvey

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.
COST ADMIRE

Aldosterone-Mineralocorticoid Receptor

Aldosterone-Mineralocorticoid Receptor

Authored by Brian Harvey

Chapters authored

The Cystic Fibrosis 'Gender Gap': Past Observations Present Understanding and Future Directions

By Sanjay H. Chotirmall, Catherine M. Greene, Brian J. Harvey and Noel G. McElvaney

Part of the book: Cystic Fibrosis

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na⁺ Transport by Non-genomic Mechanisms

By Warren Thomas and Brian Harvey

Aldosterone is the key regulating hormone of whole-body fluid and electrolyte homeostasis. Perturbations in aldosterone synthesis and over-activation of the mineralocorticoid receptor (MR) can lead to excess salt reabsorption and hypertension. The cortical collecting duct (CCD) is the main site of action in the kidney for aldosterone regulation of whole-body sodium homeostasis through actions on the epithelial sodium channel (ENaC) and the Na/K-ATPase (Na/K pump). Aldosterone stimulates ENaC trafficking into the apical cell membranes in the CCD and enhances channel stability and open probability, as well as activating the basolateral membrane Na/K pump to produce an overall increase in the transepithelial reabsorption of sodium. Aldosterone/MR regulates the activity of ENaC in the CCD through both rapid non-genomic (secs-mins) and latent genomic (hours-days) signaling pathways. These rapid and slow responses of renal Na+ transport pathways to aldosterone are often treated as distinct and separate events. However, recent evidence points to a close integration between genomic and non-genomic responses to aldosterone to regulate ENaC and Na/K pump activity via protein kinase signaling pathways. Here, we review the integration of aldosterone membrane-initiated non-genomic and nuclear genomic regulations of renal sodium transport via protein kinase signaling pathways and in particular via protein kinase D isoforms.

Part of the book: Aldosterone-Mineralocorticoid Receptor

Related collaborators

Catherine Greene

Royal College of Surgeons in Ireland - Bahrain , Bahrain

Noel G. McElvaney

Royal College of Surgeons in Ireland , Ireland

Iara Maria Sequeiros

University Hospitals Bristol NHS Foundation Trust , United Kingdom

Sanjay Chotirmall

Nanyang Technological University , Singapore

Marco Lucarelli

Sapienza University of Rome , Italy

Patrick Lebecque

Cliniques Universitaires Saint-Luc , Belgium

Batitucci

Ângela Maria Spagnol Perrone

Giselle V. Brunoro

Oswaldo Cruz Foundation , Brazil

Nabil Jarad

Bristol Royal Infirmary , United Kingdom