Levels of PBDEs reported in the environment and biota from different locales worldwide.
\r\n\t"
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:null,priceUsd:null,slug:null,numberOfPages:0,isOpenForSubmission:!1,hash:"cc796459268324e827219d1d904e4265",bookSignature:"Prof. Moulay Tahar Lamchich",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/7196.jpg",keywords:"Induction motor, smart motor, electrical vehicles, energy generation, drives, electromechanical, hybrid transportation, smart control, high efficiency motor, variable speed drives, power electronic, energy efficiency.",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 4th 2018",dateEndSecondStepPublish:"July 25th 2018",dateEndThirdStepPublish:"September 23rd 2018",dateEndFourthStepPublish:"December 12th 2018",dateEndFifthStepPublish:"February 10th 2019",remainingDaysToSecondStep:"3 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"21932",title:"Prof.",name:"Moulay Tahar",middleName:null,surname:"Lamchich",slug:"moulay-tahar-lamchich",fullName:"Moulay Tahar Lamchich",profilePictureURL:"https://mts.intechopen.com/storage/users/21932/images/system/21932.png",biography:"Moulay Tahar Lamchich is a Professor at the Faculty of Sciences Semlalia at Marrakech (Morocco). He completed his thesis in electromechanics in September 1991 and received his third cycle degree. Dr. Lamchich received his Ph.D. from the same university in July 2001. His main activity is based on short-circuit mechanical effects in substation structures, control of different types of machine drives, static converters, active power filters. In the last decennia, his research interests have included renewable energies, particularly the control and supervision of hybrid and multiple source systems for decentralized energy production, and intelligent management of energy. He has published more than fifty technical papers in reviews and international conferences. With IntechOpen, he has published two chapters and was editor of the books “Torque Control” and “Harmonic Analysis”. 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From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"878",title:"Phytochemicals",subtitle:"A Global Perspective of Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"ec77671f63975ef2d16192897deb6835",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/878.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"71864",title:"Generalized and Fundamental Solutions of Motion Equations of Two-Component Biot’s Medium",doi:"10.5772/intechopen.92064",slug:"generalized-and-fundamental-solutions-of-motion-equations-of-two-component-biot-s-medium",body:'\nVarious mathematical models of deformable solid mechanics are used to study the seismic processes of earth’s crust. The processes of wave propagation are most studied in elastic media. But these models do not take into account many real properties of an ambient array. These are, for example, the presence of groundwater, which affects the magnitude and distribution of stresses. Models, which take into account the water saturation of earth’s crust structures, presence of gas bubbles, etc., are multicomponent media. A variety of multicomponent media, complexity of processes associated with their deformation, lead to a large difference in methods of analysis and modeling used in solving such problems.
\nPorous medium saturated with liquid or gas, from the point of view of continuum mechanics, is essentially a two-phase continuous medium, one phase of which is particles of liquid (gas) and other solid particles are its elastic skeleton. There are various mathematical models of such media, developed by various authors. The most famous of them are the models of Biot, Nikolaevsky, and Horoshun [1, 2, 3, 4, 5]. However, the class of solved tasks to them is very limited and mainly associated with the construction and study of particular solutions of these equations based on methods of full and partial separation of variables and theory of special functions in the works of Rakhmatullin, Saatov, Filippov, Artykov [6, 7], Erzhanov, Ataliev, Alexeyeva, Shershnev [8, 9], etc. In this regard, it is important to develop effective methods of solution of boundary value problems for such media with the use of modern mathematical methods.
\nPeriodic on time processes are very widespread in practice. By this cause, here we consider also processes of wave propagation in Biot’s medium, posed by the periodic forces of different types. Based on the Fourier transformation of generalized functions, we constructed fundamental solutions of oscillation equations of Biot’s medium. It is Green tensor, which describes the process of propagation of harmonic waves at a fixed frequency in the space–time of dimension N = 1, 2, 3, under the action concentrated at the coordinates origin. By using this tensor, we construct generalized solutions of these equations for arbitrary sources of periodic disturbances, which can be described as both regular and singular distributions. They can be used to calculate the stress-strain state of a porous water-saturated medium by seismic wave propagation.
\nThe equations of motion of a homogeneous isotropic two-component Biot’s medium are described by the following system of second-order hyperbolic equations [1, 2, 3]:
\nHere N is the dimension of the space. At a plane deformation N = 2, the total spatial deformation corresponds to N = 3, at N = 1 the equations describe the dynamics of a porous liquid-saturated rod.
\nWe denote \n
Constants \n
where m is a porosity of the medium. The constant of attached density \n
Here \n
Further we use the next notations for partial derivatives: \n
There are three sound speeds in this medium:
\nwhere the next constants were introduced as:
\nThe first two speeds \n
We introduce also two velocities of propagation of dilatational waves in corresponding elastic body and in an ideal compressible fluid:
\nConstruction of motion equation solutions by periodic oscillations is very important for practice since existing power sources of disturbances are often periodic in time and therefore can be decomposed into a finite or infinite Fourier series in the form:
\nwhere periods of oscillation of each harmonic \n
The solution of Eq. (1) can be represented in the similar form:
\nwhere complex amplitudes of displacements \n
which give us the solution of problem for forces (4).
\nWe get equations for complex amplitudes by stationary oscillations, substituting (6) into the system (1):
\nTo construct the solutions of this system for different forces, we define Green tensor of it.
\nLet us construct \n
Here \n
Their complex amplitudes \n
Since fundamental solutions are not unique, we’ll construct such, which tend to zero at infinity:
\nand satisfy the radiation condition of type of Sommerfeld radiation conditions [10].
\nMatrix of such fundamental equations is named Green tensor of Eq. (8).
\nTo construct \n
where \n
Let us apply Fourier transformation to Eq. (10) and use property of Fourier transform of derivatives [10]:
\nThen we get the system of 2 N linear algebraic equations for Fourier components of this tensor:
\nBy using gradient divergence method, this system has been solved by us. For this the next basic function were introduced:
\nand the next theorem has been proved [11, 12].
\nTheorem 1.Components of Fourier transform of fundamental solutions have the form:\n
\n\nwhere the next constants have been introduced as:\n
\nThis form is very convenient for constructing originals of Green tensor.
\nIn this case let us construct the originals of the basic function but only over \n
which, in accordance with its definition (14), satisfies the equation:
\nUsing property (12) for derivatives from here, we get Helmholtz equation for fundamental solution (accurate within a factor \n
Fundamental solutions of Helmholtz equation, which satisfy Sommerfeld conditions of radiation:
\nare well known [10]. They are unique. Using them, we obtain:
\nwhere \n
These functions (subject to factor \n
The last property is true only for N = 2,3. In the case N = 1, all fundamental solutions of Eq. (16):
\ndo not decay at infinity.
\nFrom Theorem 1, the next theorem follows.
\nTheorem 2.The components of Green tensor of Biot’s equations at stationary oscillations with frequency ω, which satisfy the radiation conditions, have the form:\n
\nwhere
\n\nProof. By using originals of basic functions, property (12) of derivatives, we can obtain from formulas for \n
Then formulas of Theorem 2 follow from formulas of Theorem 1.
\nUnder the action of arbitrary mass forces with frequency \n
Note that mass forces may be different from the space of generalized vector function, singular and regular. Since Green tensor is singular and contains delta-functions, this convolution is calculated on the rule of convolution in generalized function space. If a support of acting forces are bounded (contained in a ball of finite radius), then all convolutions exist. If supports are not bounded, then the existence conditions of convolutions in formula (17) requires some limitations on behavior of forces at infinity which depends on a type of mass forces and space dimension.
\nThe obtained solutions allow us to study the dynamics of porous water- and gas-saturated media at the action of periodic sources of disturbances of a sufficiently arbitrary form. In particular, they are applicable in the case of actions of certain forces on surfaces, for example, cracks, in porous media that can be simulated by simple and double layers on the crack surface.
\nThere is another interesting feature of the Green tensor of the Biot’s equations, which contains, as one of the terms, the delta-function that complicates the application of this tensor for solving boundary value problems based on analogues of Green formulas for elliptic systems of equations or the boundary element method. Here, when constructing the model, the viscosity of the liquid is not taken into account, which, apparently, leads to the presence of such terms, and it requires improvement of this model taking into account a viscosity.
\nTo construct the non-stationary Green tensor, at first we also construct the originals of the basic functions in an initial space-time:
\nThey are originals of the classic wave equation:
\nDepending on the dimension of a space, solutions of this wave equation that satisfy the radiation conditions have the following form [10]:
\nHere \n
Using regularization of the general function \n
and the properties of Fourier transform of generalized functions convolution:
\nIt is easy to show that the next lemma is true.
\nLemma.The originals of the primitives of the basic functions satisfying the radiation conditions are representable in the following form:\n
\n\nfor N = 3\n
\nfor N = 2
\nfor N = 1
\nUsing these functions and the properties of the Fourier transform, we obtain the components of the Green tensor from the formulas of Theorem 1. We formulate the result in the next theorem.
\nTheorem 3.The components of Green tensor of motion equations of two-component Biot’s medium have the following forms:\n
\nHere
\nfor N = 1
\nfor N = 2
\nfor N = 3
\nUsing the properties of Green tensor, we obtain generalized solutions of non-stationary Biot’s equations under the action of arbitrary mass forces in the Biot’s medium, which satisfy the radiation condition at infinity. They have the form of tensor functional convolution:
\nIt’s taken according to the rules of convolution of generalized functions depending on the type of mass forces [10].
\nIn order to get the classic solution, we must present formulas (28) in regular integral forms. For this, let us present matrix of Green tensor as sum of regular functions and singular functions, which contain delta-function:
\nThen also write:
\nHere \n
The convolution with singular part is equal to:
\nIn 3D space, there are convolutions with simple layers on sound cones (see (27)). To construct their integral presentation, use this rule:
\nHere the internal integral is taken over sphere with center in the point x, and its radius is equal to \n
If components of acting forces \n
Substituting the formulas of Theorem 4 into (29), we obtain displacements and stresses of skeleton and liquid in Biot’s medium in spaces of dimension N = 1, 2, 3. Calculation of these convolutions by using these formulas essentially depends on the form of acting forces and gives possibility to construct regular presentation of generalized solution for wide class of acting forces, which are the classic solution of Biot’s equation.
\nUsing Biot’s law (2), we can define the generalized stresses in skeleton and a pressure in a liquid:
\nThese formulas also can be written in integral form by using the same rules. But we can apply here the next lemma, which was proved in [11].
\nLemma.Fourier transformations of the divergences of Green tensor have the next form:\n
\nFrom this lemma, we can prove easily the next theorem.
\nTheorem 4.Divergences of elastic and liquid displacement of Green tensor have the next form:\n
\nSubstituting these formulas in (30), we define the stresses in the skeleton and the pressure in the liquid of Biot’s medium.
\nIf we paste \n
The obtained solutions give possibility to study the dynamics of porous water- and gas-saturated media and rods under actions of disturbance sources of different forms and can be used for solutions of boundary value problems in porous media by using boundary element method.
\nThese solutions can be used for describing wave processes by explosions and earthquakes. In these cases mass forces are described by using singular generalized function, such as multipoles, simple and double layers, and others.
\nThis work was financially supported by the Ministry of Education and Science of the Republic of Kazakhstan (Grant AP05132272).
\nThe preservation and conservation of the environment are of great significance for healthy living. However, efforts to conserve the environment have been futile due to escalated pollution from biogenic and anthropogenic sources, which constantly release pollutants to the environment [1]. In the recent past, increased industrial and agricultural activities have immensely contributed to the pollution of aquatic environments such as rivers and streams, which pose major detrimental environmental problems to humans [2]. It is evident that industrial development has generated a myriad of new chemicals produced and applied in daily activity, which is becoming a major concern for citizens, the research community, and authorities [3]. Among the pollutant chemicals that have been introduced into the environment are polybrominated diphenyl ethers (PBDEs). PBDEs are toxic, lipophilic, hydrophobic, and persistent artificial chemicals characterized by high physical and chemical stability [4]. They are commonly applied as flame retardants in polymer products such as electronics, plastics, textiles, and building materials [5, 6]. PBDEs have become a growing concern over the last two decades due to their ubiquity, persistence and accumulation capacity in the environment, as well as their potential risks to human health and wildlife [7, 8]. PBDEs are normally additive compounds, meaning they are not covalently bound to the polymeric products [9]. Therefore, they may leach out into the surrounding environment during their production, usage, disposal, or recycling process [10]. PBDEs can be transported away from their sources for long-ranges through aqueous and/or terrestrial environmental compartments [11, 12]. In this context, monitoring and assessment of environmental pollution by these compounds are very important.
Their determination involves a series of steps from sample pre-treatment to quantification of analytes using various detection systems. Different sample preparation strategies that range from conventional to advanced strategies have been applied for the determination of PBDEs in environmental samples. Some of the conventional sample enrichment methods include Soxhlet extraction [13, 14] and liquid-liquid extraction (LLE) [15]. More recently, ultrasound-assisted extraction (UAE) [16, 17], pressurized liquid extraction (PLE) [18, 19], microwave-assisted extraction (MAE), solid-phase extraction (SPE), and solid-phase microextraction (SPME) have exhibited successful extraction of PBDEs from environmental samples [20, 21]. The application of SPE and SPME has advanced from conventional adsorbent formats to the most improved formats which allow easy transfer of analytes from their complex matrices. This has been achieved by using novel adsorbent materials to replace conventional silica-based adsorbents which exhibit low selectivity towards targeted analytes [22]. Similarly, analytical techniques for the qualitative and quantitative determination of PBDEs have advanced from well-known gas chromatography-electron capture detection (GC-ECD) to sensor-based techniques that are more advantageous in terms of excellent selectivity, with opportunities for in-situ application. The following sections provide detailed information on PBDEs, advances in sample pre-treatment methods and detection techniques with a view of providing the current state-of-the-art as far as their monitoring is concerned.
PBDEs comprise of two halogenated aromatic rings bonded by an ester bond and are classified in relation to the number and position of bromine atoms in a particular molecule [23]. They have a general molecular formula of C12H(10 - x) BrxO, where x is the number of bromine atoms in a molecule with numerical values [x = 1, 2, 3, …, 10 = m + n] (Figure 1). Substitution of bromine atoms can take place at 10 possible positions on the two benzene rings resulting in 209 possible congeners [24].
General structural formula of PBDEs.
Different congeners are easily identified by their corresponding IUPAC numbers ranging from 1 to 209. In this case, 2,2′,4,4′-tetrabromodiphenyl ether is BDE-47, with bromine atoms in ortho and para positions on the first and second benzene rings, respectively (Figure 2).
Chemical structure of 2,2′,4,4′-tetrabromodiphenyl ether (BDE 47).
Molecules with one to four bromine atoms are classified as low molecular mass PBDEs, whereas the ones with five to ten bromine atoms are categorized as high molecular mass PBDEs. Less brominated PBDEs are more persistent and toxic than highly brominated diphenyl ethers [25]. The substitution pattern also affects the physicochemical properties of PBDEs, whereby the solubility of PBDEs decreases significantly with an increase in bromine substitution. The aqueous solubility (SW) of low molecular mass PBDEs at room temperature ranges from 6.57 × 10−7 to 7.82 × 10−11 mol L−1 while those of high molecular mass have aqueous solubility values lower than 7.82 × 10−11 mol L−1 [26]. A wide range of PBDE congeners exhibit high lipophilic capacity and high resistance to degradation; a property that makes them bioaccumulate and magnify in biota [7]. PBDEs are also associated with high octanol-air partition coefficients (KOA) with values ranging between 9.3 and 12.0 from BDE-17 to -126, which is approximately 1 to 2 orders of magnitude greater than PCBs [27]. Therefore, PBDEs are easily transported through air from one point to another, increasing their chances of exposure to humans. Dissolved organic matter has shown a high tendency to interact with hydrophobic compounds such as PBDEs, which hinders their mobility and degradation in the environment [28]. Reported binding coefficients of PBDEs (log KDOC) towards organic matter range from 5.1 to 7.14, which implicates the high capability of PBDEs to adsorb and partition on organic matter [29].
PBDEs were commercially produced in three technical mixtures, typically known as pentaBDE, octaBDE, and decaBDE, basing on the number of bromine atoms [10]. By early 2000, the global production of commercial PBDE formulations was approximately 67,000 tons in the ratio 1:1.98:14.8 for octa-BDE, penta-BDE, and deca-BDE respectively, of which the United States production was approximately 50% of the global production [30]. Several governmental regulations and international environmental agencies have restricted and completely banned the use and production of some PBDE congeners [31]. In 2004, the European Union phased out the use and production of penta-BDE and octa-BDE. Consequently, in December 2004, Great Lakes Chemical Corporation, a sole manufacturer of penta-BDE and octa-BDE in North America, voluntarily phased out the production of these BDE formulations [32]. These efforts were boosted by the Stockholm Convention in 2012 when it listed commercial octa-BDE and penta-BDE among persistent organic pollutants that need to be eliminated. Despite the ban in the production of most PBDEs, they are still reported in air, soil and aquatic environments, which is attributed to their stability and subsequent release from techno-ecosystems, and production of deca-BDE, which still continues to be produced in some countries [33, 34].
There are diverse pathways by which PBDEs enter the environment. Major environmental sources of PBDE pollution comprise of leakage from consumer products and industrial facilities that synthesize PBDEs or PBDE-containing products [5]. Besides, PBDEs may enter the aquatic environment from illegal disposal of obsolete electrical appliances and electronic devices flame-retarded with PBDEs or other PBDEs-containing products [7]. They can also enter the aquatic environment through raw sewage and into the surrounding air through volatilization from products containing PBDEs and toxic fumes from e-waste recycling plants [35]. Since the first discovery of PBDEs in the aquatic environment on the West coast of Sweden in 1981, several studies have reported the presence of PBDEs in the environment [36]. This is despite the strict regulatory measures imposed by some governments and international environmental agencies to phase out some PBDE congeners and subsequent reduction in the production of particular PBDEs. BDE-47, 99, 100, and 153 are the ones that are frequently investigated because they are primary components of commercial mixtures, therefore, their ratios in the environment are expected to be significantly high. Moreover, less substituted BDE congeners such as BDE-28 and 47 are more toxic and non-biodegradable, hence their investigation in the environment and biota is of great significance in the monitoring of these pollutants [37]. Soil and sediment harbour higher concentrations of PBDEs, which is attributed to the organic carbon content, which makes them a sink for most organic pollutants [38]. Elevated levels of PBDEs have since been reported in agricultural soils after the application of sewage sludge at a concentration of 21 to 690 ng g−1 dry weight (dw) [39]. From statistics, human beings spend more than 70% of their lifetime indoors, in occupational offices, homes, learning institutions, and transport vehicles, and are therefore exposed to an array of contaminants from indoor dust [40]. The highest levels of PBDEs in dust samples have been reported in major industrialized cities in China and Europe at a concentration of 397–40,236 ng g−1 and 950–54,000 ng g−1, respectively [41, 42], with comparably lower levels of 1710 ng g−1 in African regions [43]. Table 1 presents a summary of reported PBDE levels in selected environmental matrices.
Country | Sample matrix | Concentration | Reference |
---|---|---|---|
South Africa | River water | 2.60–4.83 ng L−1 | [44] |
North America | River water | 0.00013–0.01 ng L−1 | [45] |
Great Britain | Indoor dust | 950–54,000 ng g−1 | [46] |
South Africa | Home dust | 1710 ng g−1 | [43] |
Office dust | 1520 ng g−1 | ||
Nigeria | Indoor dust | 3700–19,000 ng g−1 | [47] |
China | Indoor dust | 397–40,236 ng g−1 | [41] |
Uganda | Air | 0.00340–0.00984 ng m−3 | [48] |
Kenya | Soil | 0.19–35.64 ng g−1 | [49] |
China | Soil | 4.8–533 ng g−1 | [50] |
China | Sediment | 0.03- 5.22 ng g−1 | [51] |
China | Sediment | 0.13–1.98 ng g−1 | [52] |
Sweden | Sewage sludge | nd-450 ng g−1 | [53] |
Spain | Sewage sludge | 197–1185 ng g−1 | [39] |
Kuwait | Sewage sludge | 52.5–377* ng g−1 | [54] |
USA | Serum | 5.0–27.9 | [55] |
South Africa | Tigerfish | 5.8 | [56] |
Uganda | Breast milk | 0.59–8.11 | [57] |
Levels of PBDEs reported in the environment and biota from different locales worldwide.
Mean concentration.
nd, not detected.
The principal route for PBDE exposure to humans was thought to be through food consumption [58]. However, inhalation of contaminated indoor and outdoor dust is also a significant pathway via which human beings may be exposed to PBDEs [46, 59]. Dermal absorption is another potential route for PBDE exposure [60]. Numerous studies have reported levels up to 160.3 ng g−1 of PBDEs in human samples, such as serum and milk. Increased application of PBDEs in electronics has significantly aroused more research work on the concentration of these pollutants in the blood of workers in e-waste processing plants and other exposed populations [61]. BDE 47, 153, and 209 are the most predominant congeners reported in human serum and milk [55, 62]. The toxicity of PBDEs is backed up by numerous epidemiological studies. Scientific research has linked PBDE exposure to an array of adverse health effects [63]. To mention a few, penta- and octa-BDEs at a concentration of 10,000 ng g−1 have been associated with disruption of thyroid hormone homeostasis [7]. Moreover, penta- and tetra-BDEs, within the range of 8000–18,000 ng g−1, have been reported to affect the neurodevelopment of mice [64]. Exposure to high levels of deca-BDEs is likely to cause breast cancer [7]. PBDEs have been linked to developmental neurotoxicity and hence leading to severe effects on cognitive ability, behaviour, and health of both animals and humans [65, 66]. Several studies have also linked PBDEs with adverse effects on the human reproductive system. In particular, BDE-47, BDE-153, and BDE-154 in the range of 0.2–1.6 ng g−1 have been confirmed to have negative impacts on testosterone, luteinizing hormone, and estradiol [67]. Therefore, there is a need to have robust, accurate and reproducible methods to quantify PBDEs in different environmental matrices. The sections that follow will discuss these aspects with a particular focus on aquatic media.
Sample pre-treatment steps such as pre-concentration and clean-up are paramount before instrumental analysis [2, 68]. These steps ensure that analytes are enriched and converted into the right form/state to achieve their detection and any matrix that may interfere with the determination of the analytes is removed [69]. The choice of sample pre-treatment step is dependent on the physicochemical properties of the targeted analytes, their concentration in the environment, and the complexity of matrix interference [70, 71]. Soxhlet extraction, a traditional liquid-solid extraction method, has been used for decades in the extraction of analytes from their complex solid matrices. With the combination of polar and non-polar solvents, the Soxhlet extraction strategy has been proved to be efficacious, achieving extraction efficiencies greater than 70% [72, 73]. However, this method is hindered by several factors such as long extraction duration, excessive solvent consumption, and the need for subsequent clean-up steps [74]. With increasing demand for economical and fast sample extraction strategies with high enrichment factors, coupled with SPE clean-up procedures, techniques such as UAE, PLE, MAE, and supercritical fluid extraction (SFE) have been adopted in enrichment of analytes from solid matrices.
UAE encompasses the introduction of a finely divided sample contained in a sample holder in an ultrasonic bath with solvent and subjected to ultrasonic radiation. UAE is a vital technique in achieving sustainable green chemistry and is primarily employed in the extraction of analytes from solid sample matrices [75, 76]. This technique can achieve complete extraction with high reproducibility within a short duration. Moreover, small quantities of extraction solvents are used as compared to conventional Soxhlet extraction [77]. Methanol, acetonitrile, ethanol, and acetone are typical extractants used in this method in minimal volume. UAE based on ultrasound assisted-dispersive solid phase extraction (UAE-DSPE) coupled to GC-MS has been reported to achieve exemplary limits of detection and extraction efficiencies for 7 BDE congeners from dust samples collected from air conditioning filters in the range of 1.4–8.4 ng g−1 and 90–102%, respectively [78]. Some of the benefits of UAE include faster kinetics and an increase in extraction yield. Ultrasound can also reduce the operating temperature allowing the extraction of thermally labile compounds [79].
Unlike traditional Soxhlet extraction that consumes a large volume of solvent, PLE, also referred to as pressurized solvent extraction, has been of great interest due to its extraction effectiveness. Extraction of analytes from their environmental matrices is achieved via a synergistic mechanism that proceeds through liquid solvents at elevated temperature and pressure, which altogether enhance extraction throughput as compared with other techniques performed at ordinary atmospheric conditions [80]. PLE is viewed as another \'green\' option for traditional sample extraction methods. High temperature accomplishes a higher dispersion rate, while high pressure keeps the extraction solvent below its boiling point. During the determination of brominated flame retardants in e-waste samples, PLE and UAE were evaluated in regard to extraction efficiencies. PLE demonstrated high extraction efficiencies of 95–100% as compared to 10–50% for UAE [81]. When contrasted with the conventional methods, PLE shows a decrease in extraction time and a significant decrease in the overall consumption of organic solvents [82].
Another type of extraction technique that enables a three-fold reduction in extraction time and solvent is MAE. This is a sample extraction method that employs microwave energy to extract analytes from solid sample matrices in contact with extraction solvents. Microwave energy directly generates heat which initiates molecular motion of the analytes in the solid-solvent complex mixture, hence facilitating the mass transfer of the target analyte from the solid matrix to the extracting solvent [83, 84]. MAE has been reported to achieve good recoveries of 80–106%, 72.4–108.4%, and 80–110% in the extraction/pre-concentration of PBDEs from airborne particulate matter [85], e-waste materials [86], and sewage sludge samples [87], respectively. Compared with Soxhlet extraction, MAE achieves better recoveries and uses small amounts of solvents (30 mL versus 200 mL for Soxhlet extraction), at the same time allowing control of extraction parameters, such as extraction time and temperature [88]. However, MAE has some shortcomings, whereby the extracted sample usually contains some matrix interferences, such as lipids and lipophilic compounds, therefore, filtration and clean-up steps are required, which subsequently consume extra organic solvents.
Supercritical fluid extraction (SFE) is another method employed to extract PBDEs from solid matrices. Supercritical CO2 is often used as an extracting solvent, which has the capability of attaining recoveries above 97%. Moreover, the extraction efficiency of SFE can be further improved by the use of modifiers such as acetonitrile, toluene, and tetrahydrofuran [89]. A successful application of SFE in the extraction of PBDEs from polymeric materials was reported by Peng et al. [90]. The authors used supercritical CO2 as a solvent and SFE operating parameters such as temperature and pressure were optimized at 65°C and 20 MPa, respectively, achieving 97.6% extraction efficiency. This technique is a greener alternative to other techniques that use a large volume of solvents.
Numerous methodologies have been adopted in the determination of PBDE pollutants in liquid matrices. SPE and conventional LLE have been embraced as routine extraction techniques for PBDEs in liquid samples. The extractive capability of LLE is based on the transfer of analytes from an aqueous polar phase to a non-polar organic phase [91]. LLE coupled with GC-MS has been applied in the determination of 13 PBDEs and their metabolites in water, with recoveries of 77%-102% [92]. LLE has also been a desirable extraction method in the preparation of biota samples for the determination of PBDEs. Recently, a study aimed at assessing in utero exposure of 24 tri- to deca- BDE congeners on primiparous mothers in Kampala, Uganda reported a successful application of LLE, with appreciable recoveries of 81–91% [93]. However, LLE has some shortcomings; it suffers from low recovery, poor selectivity, high matrix interference in chromatographic analysis and increased sample loads [94]. In addition, the extraction of PBDEs from water samples requires extremely large volumes of solvents due to their hydrophobic character and low concentration in water, thus limiting its applications [95]. To overcome these challenges, different configurations of SPE have been adopted in sample enrichment strategies. SPE is a modern sample pre-treatment technique employed to concentrate analytes from liquid samples and to remove matrix interferents during the clean-up step, achieving exemplary recoveries and reproducible results over LLE [96, 97]. SPE protocols are usually performed by the use of a small column or separation cartridge packed with an appropriate sorbent material [98, 99]. Target analytes are adsorbed by the sorbent materials and later eluted with a solvent that has a greater affinity for the analytes. The chemistry behind this separation is based on intermolecular forces between the analytes, active sites of the adsorbent, and the liquid phase of the matrix [100]. SPE can be performed through an on-line or off-line approach. The on-line SPE configuration, which may enable automation, is directly coupled with specific analytical systems such as gas chromatography (GC) or high-performance liquid chromatography (HPLC). Whereas in the off-line protocol, a pre-concentration step is done separately using cartridges and further eluting the adsorbed analyte with an appropriate solvent for eventual chromatographic analysis [101]. Because of its robustness and flexibility, SPE has been widely employed in different analytical procedures in pre-concentration and clean-up steps in the determination of PBDEs [96, 102].
While SPE continues to be used because of its affordability and ease of use, other formats that offer high enrichment factors and shorter extraction times, such as SPME, stir-bar sorptive extraction (SBSE) and dispersive solid-phase extraction (DSPE), have been introduced [103]. SPME is an innovation and improvement of conventional SPE. Its stationary phase comprises of fused-silica fibers coated with a polydimethylsiloxane (PDMS) layer which are reusable. With this new formulation, the application of SPE has become versatile such that it can accommodate small volumes of samples. Furthermore, SPME has been considered an almost solvent-free extraction technique and can be easily automated as compared to conventional SPE [104, 105]. A miniaturized SPME has been applied in the extraction of PBDEs in environmental water samples followed by GC-MS quantitation, with low limits of detection and appreciable recoveries of 76.5–125.4% [106]. SBSE is a similar technique to SPME that has been adopted in the enrichment of PBDEs in liquid samples due to its improved extraction efficiency. The stir bars are coated with a thinner PDMS layer, as opposed to a thicker layer in SPME, a factor that allows improved enrichment efficiency [107, 108]. DSPE is another format of SPE based on the dispersion of solid sorbent materials in liquid samples to facilitate the isolation and extraction of target analytes from the complex sample matrix. In this process, matrix interferences remain embedded in the supernatant, which is later discarded while the target analyte is bound to the sorbent material and which is eventually eluted with a viable solvent [109]. DSPE has been employed in the enrichment and determination of PBDEs with recoveries within the range of 60–140% [110].
Complexity and matrix interferences encountered during sample preparation steps have attracted the invention of more selective sorbents to replace conventional silica sorbents that are associated with a number of drawbacks, such as instability at extreme pHs and low extraction efficiencies [111]. The new sorbents that include, nanocomposite materials, metal-organic frameworks, and molecularly imprinted polymers, among others, are characterized with high sensitivity and selectivity towards various environmental organic pollutants. They achieve fast dispersion and efficient recycling when applied in complex sample matrices [112, 113]. Reported nanocomposite sorbents in SPE for PBDE-containing samples include carbon nanotubes, graphene oxide (GO) [114, 115], and magnetic nanocomposite materials [113]. However, nanocomposite sorbents in classical SPE schemes have been associated with various drawbacks. A few of these challenges have been described in flow as well as batch systems, which originate from a slow flow rate of the sample through the packed SPE column and difficulty in separating the sorbent from the large volume of aqueous sample [113].
Other sorbent materials with fascinating properties are metal-organic frameworks (MOFs). These are hybrids of organic and inorganic materials characterized by a porous structure, large surface area, uniform nanoscale cavities, high adsorption capacity, and high thermal and chemical stability. Due to these advantageous properties, this class of materials has recently attracted enormous attention in the field of sample preparation [116]. The development of MOF adsorbents is still at its infancy stages, therefore, a limited number of studies have reported their application particularly in enrichment and determination of environmental PBDEs. A zirconium-based metal-organic framework material (UiO-66-OH) is a good example of a MOF. It has been synthesized and successfully applied as an adsorbent in SPME for enrichment and detection of 5 BDE congeners in milk samples using GC-MS, with low limits of detection in the range of 0.15–0.35 ng L−1 and excellent recoveries of 74.7%–118.0% [117]. A contrast study using silica-based sorbents in SPE for determination of 12 PBDEs in human serum, achieved mean recoveries of 64–95% and limits of detection in the range of 0.1–4.0 ng g−1 by using GC-MS [102], an evidence that MOF sorbents offer promising analytical results as compared with conventional sorbents.
With growing interest in sorbents that offer extraordinary extractive capability in SPE, molecularly imprinted polymers (MIPs) have been extensively explored as attractive options due to their robustness and selectivity towards particular target analytes providing exemplary substitute sorbents in sample clean-up and pre-concentration steps, especially in SPE and SPME [118]. MIPs are synthesized through molecular imprinting technology that involves polymerizing functional and cross-linking monomers in the presence of a target analyte, followed by the removal of the analyte to leave behind analyte-specific cavities. Their selectivity enables substantive removal of matrix interferents during the sample pre-treatment step [119]. MIP-based sorbents are readily available substitutes to silica-based adsorbents, which are reported to suffer from matrix interference, low selectivity, and sensitivity towards organic pollutants and may involve multiple steps that are labour-intensive for complete removal of interferences [120]. For example, commercial molecularly imprinted solid-phase extraction (MISPE) cartridges alongside alkaline extraction have been applied in aqueous enrichment and quantitation of PBDEs using GC-MS [121]. The extraction of PBDEs using MISPE gave recoveries above 60% compared to alkaline extraction which was below 60%. This confirms the selectivity capability of MIPs towards PBDEs from a complex environmental matrix. A more recent study has also reported recoveries of 60–87% in clean-up of soil and sediment samples using dummy molecularly imprinted polymers as SPE sorbent materials during determination of BDE-47 and BDE-99 [122].
However, a wide range of limitations still exist in MIPs, especially their poor water compatibility. Consequently, since MIPs and target analytes mainly interact through hydrogen-bonding, their recognition capability would be easily disturbed by polar solvents such as water. Therefore, the adsorption process is normally performed in non-polar or low-polar solvents such as dichloromethane and n-hexane rather than polar solvents. Additionally, polar solvents have a tendency to occupy binding sites, which affects the recognition capacity for the target analytes. In this context, it is necessary to continually invent new synthesis strategies for water-compatible MIPs [123, 124]. A summary of some of the sample pre-concentation strategies and their extraction efficiencies is presented in Table 2.
Sample preparation technique | PBDE congeners | Sample analyzed | Analytical technique | % Recoveries | Reference |
---|---|---|---|---|---|
SPE | BDE-28, 47, 49, 66, 85, 99, 100, 138, 153, 154, 183 & 209 | Human serum | GC-ECD | 64–95 | [102] |
BDE-47 and 99 | Soil and bottom sediment | GC-MS | 60–87 | [125] | |
PLE | BDE-28, 47, 99, 100, 153, 154 & 183 | Soil | GC-MS | 95 ± 9 | [68] |
BDE-28, 47, 99, 100, 154, 155 & 183 | Soil and sediment | GC-MS | 84–103 | [92] | |
LLE | BDE-17, 28, 47, 66, 71, 85, 99, 100, 138, 153, 154, 183 & 190 | Soil and sediment | GC-MS | 85–103 | [92] |
Soxhlet extraction | 42 mono- to deca-BDEs | Indoor dust sample | GC-MS | ≥ 70 | [72] |
UAE | BDE-1, 3, 7, 8, 28 & 47 | Industrial effluent | HPLC | 98.7 | [126] |
SPME | BDE-49, 99, 100, 153 & 154 | Milk and water | GC-ECD | 90–119 | [127] |
MAE | BDE-47, 99, 100, 138, 153, 154, 184 & 209 | Sewage sludge | GC-MS | 80–110 | [87] |
Examples of sample preparation strategies.
Sample pre-treatment steps are followed by quantification of the analytes using various detection systems. The choice of detection system depends on the physicochemical properties of the target analyte and the required detection levels. Detection techniques for quantification of PBDEs have evolved from liquid chromatography to gas chromatography and recently, miniaturized systems that involve the use of sensors. For chromatographic techniques, it’s important to optimize the operational parameters to actualize reliable instrumental results. It is highly recommended to use a sample injector with programmed temperature vaporization (PTV) to avoid degradation of thermally labile BDE congeners. Additionally, the temperature of injection should be accurately defined, especially when using a split/splitless injector, which minimizes chances of thermal degradation of higher BDEs congers as well as discrimination of lower brominated congeners [95, 128]. The choice of a column is another important aspect in the analysis of PBDEs where lower brominated congeners are well separated on longer columns, whereas higher brominated congeners are well separated on shorter columns. In the case of a mixture comprising of a wide range of BDE congeners, a short column is highly recommended, which well separates nona- and deca-BDEs [129]. HPLC coupled with mass spectrometry (MS), is one of the chromatographic techniques which has rarely been applied in the quantification of some PBDE congeners. The HPLC separation is hindered by several factors such as poor solubility of highly brominated diphenyl ethers in the polar solvents of the mobile phase, especially in reversed-phase, and, thus, requiring the sample to be enriched with an organic modifier. Normal phase HPLC has offered better separation of some PBDEs though it still results in incomplete separation, especially when an electrospray ionization detector is incorporated [130]. One group used an automated on-line sample preconcentration device coupled with HPLC-MS to determine decabrodiphenyl ether in human serum samples. This method achieved detection limits of 26.0 ng L−1 [130]. Otherwise, better detection limits of 0.2-25 ng L−1 were tenable when similar samples were analyzed for 12 PBDEs including decabromodiphenyl ether using gas chromatography-electron capture detection (GC-ECD) [102]. However, GC-ECD exhibits low selectivity and suffers from matrix interferences originating especially from halogenated species, as compared to GC-MS, which overcomes these challenges [131]. Fontana et al. [16] employed a coupled system, ultrasound-assisted emulsification microextraction-GC-MS (UAEMA-GC-MS) to determine PBDEs in water samples, with appreciably low detection limits of 1–2 ng L−1. Moreover, lower limits of detection are achievable when tandem-mass spectrometry (MS2) is utilized. For example, GC-MS2 has been reported to achieve detection limits within the range of 0.002–0.0136 ng g−1 lipid weight (lw) in the determination of PBDEs in breast milk and serum samples [132].
With the recent technological revolution, a more sensitive mass spectrometer, a high-resolution mass spectrometer (HRMS), has been found to be a promising alternative to a conventional mass spectrometer as it identifies the analyte without mass fragmentation and at the lowest mass unit [133]. With this new format of detection, very low detection limits of 0.000262–0.046 ng g−1 for 23 PBDEs in dust samples were achieved [134]. However, GC-HRMS is more expensive than conventional GC-MS, compelling researchers to often rely on GC-MS since it is less expensive and readily available. Besides, the demand for techniques that provide rapid results at minimal cost has resulted in the introduction of sensor technology in the determination of PBDEs. In this context, various detection systems have been fabricated and shown a discerning capability in the detection of PBDEs. For instance, an immunoassay detection system based on graphene oxide-polydimethylsiloxane has demonstrated desirable limits of detection of 0.018 ng g−1 for PBDEs in a standard solution and environmental water samples [135]. Similarly, a novel electrochemical immunoassay sensor used for the detection of BDE-28, 47, 99, 100, 153, and 154 in food samples, achieved a detection limit of 0.00018 ng L−1 [136]. These limits are comparable with those obtained by HPLC, GC-MS, or GC-HRMS. A surface-enhanced Raman scattering-based sensor is another detection system that has been successfully applied for rapid detection of BDE 47 in aqueous media, with detection limits of 0.0364 ng L−1 [137]. The use of sensory techniques is cheaper and a low concentration of contaminants can be detected. Moreover, the analysis duration is reduced from 10 minutes to 3 minutes. Thus, these sensor methods offer scope for further evaluation.
This chapter has discussed PBDEs as emerging environmental pollutants, their sources, and toxicological implications on humans and their determination in the environment. Sample pre-concentration methods for PBDE-containing samples that include UAE, PLE, UAME, PLE, SFE, SPE, SPME, SBSE, and DSPE have been critically reviewed as preferred alternatives to LLE and Soxhlet extraction due to their enhanced extraction efficiency. Novel SPE and SPME sorbents that provide the desired selectivity in the determination of PBDEs have also been discussed. Though these sorbents are promising, their application in MISPE in the determination of PBDEs has been scantly employed and its dynamics are still at its infancy stages. Therefore, there is room for continuous introduction of highly selective materials for the quantification of PBDEs in the environment. Alongside the evolution of sample pre-treatment techniques for the detection of PBDEs, rapid sensor-based techniques that achieve the desired figures of merit similar to traditional instrumentation techniques have demonstrated great potential.
ENN is grateful to the FLAIR fellowship programme, which is a partnership between the African Academy of Sciences and the Royal Society, funded by the UK Government’s Global Challenges Research Fund (GCRF), for financial support. BSM and VON thank the National Research Foundation (NRF) of South Africa, the University of KwaZulu-Natal (UKZN) and the UKZN Nanotechnology Platform for research support. BSM is also grateful for support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 734522, and for funding from NAS, USAID and DST (South Africa), under the PEER program cooperative agreement number: No. AID-OAA-A-11-00012.
The authors declare no conflict of interest.
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