Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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The deployment of renewable dispersed generation systems and energy storage units uncovered the need for smart metering to oversee and control those generation systems. This chapter presents the design and development of a robust, efficient, multi-functional, and low-cost smart meter. The proposed metering system has added features that enabled the utilities to recover the meter energy measurement data remotely. The system allows monitoring and transmission of energy consumed in real-time. It considers using a microcontroller board as the controlling unit to execute control and monitor activities. A liquid crystal display displays standard electrical measurements such as current, voltage, power, and energy consumption. The external communication device is required in the unit’s actualization, in conjunction with the control unit based on the existing mobile technology. It stands as the intermediary between the nearby available utility station and consumers or end-users. 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The arrival of new Low-Power-Wide-Area-Networks (LPWANs) technologies has opened up new technology integration possibilities in AMI. However, it is essential to understand the AMI architecture, envisioned application types, network requirements, features and limitations of existing technologies to determine a technology’s integration suitability in an application for smart metering technology. 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The western region of Libya is the most affected part especially after the civil war in Tripoli 2014. This chapter focus on the assessment of energy production by Al-Zawia Combined Cycle Power Plant “Al-Zawia CCPP” and Western Mountain Power Plant during the period of blackouts and insecurity. In addition, to figure out the main causes of the frequent blackouts and outages in order to find practical solutions to ease the severity of the problem. This research is done based on the data are collected from the recorded data in Al-Zawia CCPP and Western Mountain power plant during the last two years 2019–2020. The data shows the instability of the annual energy produced from Al- Zawiya PPCC and Western Mountain Power Plant in 2019, also illustrates the improvement in the total produced energy by the six gas units of the Western Mountain power plant after the end of the war on Tripoli in 2020. 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1. Introduction
Even though there is no global consensus on the optimal rate of cesarean section (CS), nevertheless the World Health Organization (WHO) advocates that this should be approximately 15% of all live births [1]. Many developed countries over the past 30 years are well in excess of this rate, without there being any significant improvement in either maternal or neonatal outcomes [2]. A study conducted on a worldwide scale using country-level data has found that as CS rates exceed 10% and increase up to 30% there is no essential effect on reducing maternal and neonatal morbidity or mortality rates. Moreover, the initial inverse relationship observed between CS rates and morbidity or mortality appears to be explained by socioeconomic factors [3].
The latest epidemiological data from Western countries has placed Greece among those with the highest CS rates reaching 54% for the year 2018 [4]. This rising CS trend however is not uncommon and represents a universal finding over the past decades [5]. The CS rate for 2019 in Canada was 29.1% [6] and for 2018 in the United States of America was 31.9% [7], whereas in the United Kingdom was 26.1% (Figure 1). Since an increasing number of women delay their first pregnancy until after the third decade of their life and as the percentage of women with obesity is getting higher, this constitutes a high-risk environment for more CS births in the future [8]. At present, it is contemplated that one in three newborns are born with a CS worldwide.
Figure 1.
Cesarean section trends in selected OECD countries for the time period between 2000 and 2017. (Source: OECD Health Statistics 2019. Access: https://DOI.org/10.1787/888934017937).
2. Mode of birth and the neonate
2.1 Neonatal outcomes
Cesarean birth has been associated with a variety of adverse neonatal outcomes in the literature. Fetal and neonatal complications include the increased risk for neonatal intensive care unit admission, respiratory morbidity, and mother-infant separation with all its consequences [9]. While CS delivery has been regarded as a method to reduce the risk of neonatal asphyxia, Kupari et al. [10] in their review found that the rate of neonatal intensive care admissions is higher after a cesarean birth. A recent study at a university based-tertiary hospital in Jordan showed that 50.5% of all deliveries were by CS, and from those 72% were performed at term. However, 30% of the newborns with a cesarean birth were admitted to the neonatal intensive care unit (NICU). The rate of NICU admissions was 23% among the elective ceserean births when compared to 43% among the emergency ceserean births. It is noteworthy that among the term neonates who were admitted to the NICU almost two thirds were born by elective CS between 37 and 386/7 weeks of gestation. Moreover, an estimated 18% of NICU admissions were complicated by sepsis and the mortality rate was 5% [11]. An earlier study also showed that an elective CS is associated with an almost two-fold increase in the rate of newborn transfers to the neonatal intensive care unit, and in the diagnosis of transient tachypnea of the newborn when compared with a planned vaginal birth [12].
Recent studies have highlighted the close interplay between host genetics, the prenatal environment and the route of birth on determining the newborn’s microbiome at birth. There is emerging evidence that neonates born by CS have different hormonal, physical, bacterial, and medical exposures, and that these exposures can subtly alter their physiology. The short-term risks of CS include the altered immune system development, the increased likelihood of allergy, atopy and asthma, and the reduced diversity of the intestinal microbiome. It is not clear in the literature how these alterations might affect the children’s health later on in life as young adults, although there is accumulating evidence of long-term effects. In the literature it is quoted that we have just started to realize the importance of the developing neonatal microbiome for the future health outcomes of the individual [13].
Formation of the microbiome begins in utero and the resulting disturbances may lead to changes in the fetal epigenetic programming [14]. Factors related to the labor and birth environment have been shown to influence the initial colonization process of the newborn microbiome. Studies have shown that there are distinct differences in the microbiome profiles of newborns born vaginally when compared to those born by CS [15]. The microbiome signature of pregnancy is dynamic and it changes throughout gestation even though the factors that regulate such changes are not yet fully understood [16]. It is possible that gestational changes in the microbiome may occur as a natural mechanism to prepare for the initial transfer of microbes to the newborns [15].
There is evidence showing that children born by a CS versus those born vaginally are more likely to develop immune-related disorders such as asthma and allergies [17], inflammatory bowel disease [17], and obesity [18]. These findings have led some researchers to suggest that the association between chronic disease and route of birth may be caused by alterations in the microbiome seeding of the neonate following the cesarean birth [19]. The hypothesis is that the mode of delivery affects the epigenetic state of the stem cells of the newborn, thus impacting on their plasticity and responsiveness later on in life [14]. It is important to note that neonates born to a CS when compared to neonates born vaginally have a smaller degree of similarity to the intestinal microbiome of their mother, which includes skin and oral cavity microbes, and bacteria from the operating room [18]. Furthermore, it has been shown that children with a slight exposure to their mother’s vaginal microbiome during labor, even if they were delivered by a CS, have a reduced risk of developing asthma than those born with an elective CS [17].
There is evidence that the previously described differences in the microbiome remain long term, and the adults who were born with a CS have fecal microbiota that are distinctly different from those of adults who were born vaginally [20].
2.2 Alterations to the neonatal microbiome
It has been shown that for neonates born with a CS, their microbiome consists of different maternal microbiota than in neonates born vaginally. Bacteria from the operating room [18] have also been found to be present, while the antibiotics that women receive intrapartum to reduce the risk of post-operative infection may also affect the newborn’s microbiome [21]. The question that has been raised in the literature is how the neonate can counter these alterations in its microbiome. An intervention that has been proposed involves the medical, midwifery and nursing personnel adopting a mother-friendly, family-centered approach in the operating room during the cesarean birth [15]. Early skin-to-skin contact with the neonate, early initiation of breastfeeding and support in a maternal-focused environment with a concurrent reduction of the time-spams of separation between the mother and the newborn while the neonate is hosted in the nursery, may also result in minimal disturbances to the neonatal microbiome. Breastfeeding after a cesarean birth may potentially be the way to minimize the adverse effects of the mode of delivery on the neonate’s microbiome by promoting optimal early newborn microbiota formation. This may occur despite the effect of the antibiotics given to the mother during the CS, which have been found to lower the counts of Bifidobacterium species in breast milk that are known to prevent infection and to provide anticarcinogenic capacities to the newborn [22].
Epigenetic programming during the perinatal period may induce very important physiological changes to the neonate. Potential adverse events may lead to epigenetic changes with serious implications for health and disease. There are studies as discussed earlier that suggest that epigenetic alterations are linked to early life environmental stressors such as the mode of delivery. However, it seems that epigenetic modifications due to perinatal environmental exposures can be potentially reversible [14]. It seems that during the first 3 years of life starting from conception to the second birthday of the child, there is a high turnover of the different types of colonizing bacteria, after which the microbiome is more stable [23].
3. CS and breastfeeding
3.1 The benefits of breastfeeding to the neonate and the mother
Among the postnatal factors that may contribute to lifelong health and disease through epigenetic mechanisms, infant feeding seems to play a key role (Table 1) [23]. Maternal breast milk is universally considered to be the normative standard for infant feeding, as it confers unique nutritional and non-nutritional benefits that could in some extent be explained through epigenetics [24]. WHO promotes early breastfeeding initiation during the first hour postpartum, exclusive breastfeeding up until the 6th month and maintaining breastfeeding up to the second year of the infant’s life or more in order to optimize its growth, development and good health [25]. The special content of breast milk with long chain poly-unsaturated fatty acids [26], oligosaccharides [27], lactoferrin [28] and other important nutrients makes it the ideal nutrition for newborns and infants.
A meta-analysis on the short-term effects of breastfeeding has indicated that breastfeeding reduces the severity of diarrhea and the risk of hospitalization and mortality due to respiratory infections by 72% and 77%, respectively [29]. With regards to the long-term effects of breastfeeding, another meta-analysis was performed by the World Health Organization in 2007 and was updated in 2013. The most recent meta-analysis suggests that a causal association exists between breastfeeding and the increased performance in intelligence (IQ) tests during childhood and adolescence, and has been estimated to lead to an average increase of 3.5 points of IQ score. Though the maternal intelligence scoring (IQ) was acknowledged as an important confounder, nevertheless it accounted for a small part of this association. The practical implications of this finding of the small increase of performance in intelligence tests are not yet clear [30].
The meta-analysis of 2013 also found a small reduction of about 10% in the prevalence of overweight or obese children exposed to longer durations of breastfeeding. However, there were confounding factors related to this finding since in the majority of study settings the duration of breastfeeding was higher in families with a higher educational and economic status. Breastfeeding was also found to have a protective effect against type-2 diabetes particularly among adolescents. Furthermore, a small protective effect of breastfeeding against systolic blood pressure was found, however as the authors state, residual confounding cannot be ruled out [30]. Finally, the American Association of Pediatrics [31] states that breastfeeding plays a protective role against the sudden infants death syndrome.
Breastfeeding confers numerous short-term and long-term benefits to the mother [25]. Women who do not breastfeed are in a greater risk of developing breast cancer and ovarian cancer [32, 33]. The protective role of breastfeeding is even greater among mothers with the BRCA1 mutation, and it has been estimated that those who breastfeed for at least one year have a 37% lower risk of breast cancer [34]. There is growing evidence indicating that breastfeeding seems to have a protective role against obesity later on in the mother’s life [35]. Breastfeeding also confers a lower risk of developing diabetes mellitus [36] and hyperlipidemia [37]. Studies have shown that even a single month of breastfeeding significantly reduces the risk of developing diabetes in later life [38]. Finally, it seems that breastfeeding and especially long term with a duration of more than 7 months, reduces the maternal risk of hypertension and cardiovascular disease [39, 40].
3.2 Cesarean birth and the initiation of breastfeeding
Though the importance of breastfeeding is well established in the literature, the way by which the mode of delivery interferes with breastfeeding is still obscure. A systematic review and meta-analysis has shown that newborns born with a CS are almost half as likely to initiate breastfeeding before hospital discharge when compared to newborns born vaginally [41]. There is an abundance of literature reports since the late 1990’s showing that women who deliver by CS are less likely to breastfeed and most probably will delay breastfeeding initiation. A recent study in Canada found that women planning to have a cesarean birth had no intention to breastfeed or did not initiate breastfeeding (7.4% and 4.3%, respectively) when compared to women with vaginal births (3.4% and 1.8%, respectively) [42]. This finding is further supported in the literature by a study from Ohio in the United States of America indicating that women who underwent a scheduled repeat cesarean delivery were less likely to initiate breastfeeding than those having a successful vaginal birth after a previous CS and those who ultimately delivered by cesarean birth after an unsuccessful trial of labor [43]. It seems that maternal choice for the mode of delivery may also influence her decision to breastfeed. This is a key element that needs to be thoroughly addressed by health care professionals, since to date the motivation of mothers to breastfeed is the most important determining factor for the success of breastfeeding. Another recent study in China calculated that the unadjusted odds ratio [OR] for lower breastfeeding rates associated with CS was 2.11 [95%CI: 1.58–2.81] and 1.36 [95%CI: 1.01–1.83] at the 5th day and 6th month post delivery. After adjusting for early breastfeeding behaviors, it is interesting that the negative effect of CS on long term breastfeeding was attenuated and was no longer significant. In fact, the authors of this study noted that although cesarean birth had a detrimental effect on early breastfeeding behaviors and long-term breastfeeding outcomes, it is not per se a negative factor. It rather seems that infants who have feeding difficulties in the immediate postpartum period may experience long-term feeding problems [44].
The main question therefore is whether being born with a CS increases the difficulties in breastfeeding. There is evidence that a CS can act as an independent risk factor for reduced breastfeeding rates due to the difficulties of early lactation for the mother and baby. In a recent study, women having a CS experienced more difficulties with breastfeeding, while those having an emergency CS were more likely to have an unsuccessful first breastfeeding attempt and were unable to breastfeed their baby within the first 24 h and upon leaving the hospital, than those having a vaginal birth [42]. These difficulties might originate from maternal reasons such as the adverse effect of the administered anesthesia drugs [45], postpartum maternal fatigue after a long eventful labor, or due to postpartum wound pain after the surgery [46]. Mothers after cesarean birth report greater pain scores when compared to those women having a vaginal birth, and more problems with latching on and positioning of the baby during breastfeeding [47]. Mothers after a cesarean birth need to deal with some practical difficulties, such as having to try to breastfeed with a drip in their arm, or not being able to move around easily and pick up their babies as easily as mothers after a vaginal birth. These minor issues can enhance maternal fatigue and postpartum depressive feelings following the birth [46].
Moreover, there has been fair discussion in the literature about the hormonal impact of cesarean birth on lactogenesis. Lactogenesis is the process of developing the ability to secrete milk and involves the maturation of alveolar cells. Stage I lactogenesis takes place during the second half of pregnancy whereas stage II lactogenesis starts with copious milk production after delivery. As the placenta detaches after the delivery of the neonate, there is a rapid drop in progesterone which enables the other hormones that are present in high levels such as prolactin, cortisol and insulin, to stimulate breast milk production. It has been noted that in primiparous women, stage II is slightly delayed and early milk volume is lower. A lower milk volume was also observed in women who had cesarean births compared with those who delivered vaginally [48]. It is postulated that the hormonal pathway that stimulates lactogenesis is disrupted by a CS delivery, either because of maternal stress or decreased oxytocin secretion, and can hinder the milk production [49]. This means that mothers following a cesarean birth may encounter more practical difficulties while trying to breastfeed than mothers after a vaginal birth [50].
Another issue is the breastfeeding difficulties of the new-born after the CS delivery. It has been noted that neonates after a cesarean birth are more likely to display poorly coordinated tongue movements and to perform unsatisfactory infant sucking activity [51] due to drug exposure or to a long tiring labour. Neonates born by CS are more likely to have mucus secretions, which can affect how interested they are in feeding [52]. Intravenous fluids administered during labour can cause mothers’ breasts to become swollen, making it harder for the newborn to latch on properly [53].
Another important inhibiting factor to breastfeeding after a CS is the psychological factor, namely the loss of confidence. Mothers and especially those after an emergency CS might be less likely to believe in their ability to nurture and feed their baby as they experience increased feelings of failure. In addition, their family members are usually more likely to suggest offering formula milk to the newborns so they could rest after the surgery [52]. This suggestion may sometimes also originate from the health care personnel along with the advice to keep the newborn at the nursery for long periods of time or overnight in order for the mother to sleep. Long separation periods between the mother and newborn make lactation establishment more difficult. It is a vicious circle where mothers do not trust their body to produce enough milk, those around them make them feel that they are not capable of feeding their offspring and that leads mothers quitting breastfeeding before practically ever starting it [54].
One of the major factors that has been acknowledged for its contribution to breastfeeding success is the early onset of lactation. Unfortunately, it has been proven that cesarean birth neonates have a delay in their onset of lactation as in many cases mother to baby contact inside the operating theatre is delayed, and when offered it is usually shorter in duration than recommended or even absent [55, 56]. Skin-to-skin contact begins ideally at birth and should last continuously until the end of the first breastfeeding [57]. This practice involves placing the dried, naked newborn in a prone position on the mother’s bare chest, and sometimes can be covered with a warm blanket. Women and newborns that practice skin-to-skin contact immediately after birth have been proven to show increased rates of breastfeeding at hospital discharge and up to six months postpartum [57].
3.3 Skin-to-skin contact after a cesarean birth
As mentioned above, early skin-to-skin contact is a key element for the success of breastfeeding as it leads to early initiation of breastfeeding and to the maternal hormonal response, that is the secretion of oxytocin and endorphins which are important to establish lactation [57]. Skin-to-skin contact provides however far more benefits for the mother and baby. This intimate contact evokes neurobehaviors that ensure the fulfillment of basic biological needs and affects the future programming of the infant’s physiology and behavior [57]. It is beneficial for the newborns by improving their cardio-respiratory stability [57], their thermo- and glucose regulation [57, 58], and it also reduces the stress of birth while facilitating a smooth transition to extrauterine life [59]. Moreover, since newborns born by CS do not acquire maternal vaginal microbes, skin-to-skin contact immediately after birth permits the microbial colonization of the newborn with maternal skin microbiota [60]. Mothers after a cesarean birth also benefit by appropriate skin-to-skin contact with their newborns, since due to the boost in oxytocin secretion it has been found that the risk of postpartum hemorrhage is ameliorated [61]. In addition, it reduces maternal stress, anxiety, and pain during and after the CS delivery [57]. Long term, it seems that skin-to-skin contact has significant positive effects on reducing the maternal depressive symptoms and the physiological stress she experiences during the postnatal period [62].
Although the WHO guidelines [25] state that keeping the mother and baby together for at least the first hour after birth leads to an improved initiation and duration of breastfeeding, however it is not always as easy to apply for women having a CS and especially an emergency CS [63]. Nevertheless, skin-to-skin contact is recommended by the relevant health authorities such as the National Institute for Health and Care Excellence (NICE) [50] and the Pan American Health Organization [64]. It has been reported that early initiation and a long duration of skin-to-skin contact when compared to a short time duration, has a dose–response effect on breastfeeding [65]. A recent study has shown that for infants after vaginal delivery, the average time from birth to first breastfeeding was 40.91 minutes, while for CS newborns the average time was 74.54 minutes. The duration of the first breastfeeding was maintained for 18.33 minutes for babies after a vaginal delivery, and only 14.98 minutes for those after cesarean birth (p = 0.00). Newborns after a vaginal delivery maintained a longer sucking duration for the first (p = 0.000) and second (p = 0.008) day postpartum. Correspondingly, cesarean birth newborns were more frequently (p = 0.000) supplied with formula, and they consumed more volumes (p = 0.000) of formula within the first 72 hours after birth [44]. In another quasi-experimental feasibility study in the United States of America, it was shown that women who practiced immediate skin-to-skin contact with their newborns during their CS surgery (within one minute after birth) were more satisfied with the experience and had lower levels of salivary cortisol across time (p = 0.015 and p = 0.003 respectively) than those who practiced early skin-to-skin contact (within the first hour after birth) [66]. It has been reported in the literature that in those cases where the mother is not capable of performing skin-to-skin contact during the surgery then the father can hold the baby [66, 67]. Although this can be a reliable alternative, a recent study found a statistically significant association between skin-to-skin contact with the mother and the exclusive breastfeeding rates upon discharge, which was maintained at three- and six-months postpartum, when compared to the groups that had paternal skin-to-skin contact or no skin-to-skin contact at all [67].
3.4 Cesarean birth and the duration of breastfeeding
As already mentioned, there is scientific evidence showing that a CS can lead to the early discontinuation of breastfeeding [68]. On the other hand, there are earlier studies showing that cesarean birth does not affect the duration of breastfeeding if women initiate breastfeeding from the time point of birth and maintain it for at least four weeks postpartum [69]. In a recent prospective cohort study of 3,021 women in Canada, it was shown that the mode of birth is a significant independent predictor for breastfeeding cessation at or prior to 12 weeks postpartum (p = 0.014). In the adjusted multivariable logistic regression model, women who had a planned CS were more likely to have early cessation of breastfeeding [≤12 weeks] [OR = 1.61; 95%CI: 1.14-2.26; p = 0.006] when compared to those who delivered vaginally. There was no significant difference in breastfeeding cessation between women who had an emergency CS and women who delivered vaginally in the adjusted analysis [42] (Table 2).
Another study found that cesarean births were associated with lower rates of exclusive breastfeeding at 6 months, with no difference found between planned versus emergency CS [70].
There is a large systematic review and meta-analysis on breastfeeding outcomes after cesarean birth that included data of 53 studies from 33 different countries. Prior and colleagues (2012) identified lower rates of any breastfeeding and exclusive breastfeeding at 6 months among women who had a cesarean birth (planned or unplanned) when compared with a vaginal birth (normal or instrumental). However, based on a subgroup analysis they found that although cesarean birth was associated with lower rates of initiation, those mothers who did initiate successfully were as likely to exclusively breastfeed at 6 months with those who had a vaginal birth. This important finding suggests that early interventions could be very effective following a cesarean birth in terms of establishing lactation and continuation of breastfeeding for a long period of time [41].
4. Effective interventions to promote early breastfeeding initiation following a cesarean birth
4.1 Prenatal preparation
Decisions about infant feeding are determined by a range of complex factors including the woman’s socio-demographic background, age, ethnicity, and peer support network [71]. To date, the most important factor for the success of breastfeeding is the mother’s motivation. As it has been commented earlier, mothers planning to have a cesarean birth report lower level of willingness to breastfeed their offspring [42, 43]. It has been reported in the literature that all health professionals need to look closely into this fact and identify the reasons that drive women to this decision. Antenatal programs addressing the importance of breastfeeding both for mothers and babies, with emphasis to the key effects on CS newborns’ health need to be implemented. There is a false impression that women after a CS are not able to breastfeed adequately their offspring and this involves the women themselves, their families and exists even among health professionals. As mentioned above, women after a CS may face more difficulties than women following a vaginal birth but with adequate help and consultation from health professionals and their family, they are able to provide the best nourishment to their newborns. The women themselves express lack of knowledge and skills about breastfeeding after the CS birth [54]. During the antenatal courses, midwives have the opportunity and ability to provide this knowledge in a secure relaxed environment and demonstrate coping strategies that women can easily rehearse and learn prior to their birth. This way their confidence will increase, and they will feel more confident and ready to breastfeed their newborns after their CS.
4.2 The importance of adequate bonding time
We know from the neuroendocrine mechanisms involved in the initiation and maintenance of lactogenesis that the mother-to-newborn contact is the most effective and powerful stimulus to milk production. Health professionals need to ensure undisturbed immediate or early skin-to-skin contact for mothers and their newborns after a cesarean birth. Skin-to-skin contact is a practice that requires minimal organizational effort or costs for the hospitals that offer it [67]. Numerous studies show that skin-to-skin contact is an easy to apply, low-cost and safe intervention that can have important health benefits both for the mother and newborn, as described in the previous sections. There are studies that prove the feasibility of applying this method to women undergoing an uncomplicated CS, and even on an emergent basis, while skin-to-skin contact can safely begin during surgery and continue uninterrupted for an extended time duration [66]. As an alternative, when the mother is not capable or willing to provide skin-to-skin contact, then the partner can assist and hold the newborn [67]. Furthermore, the health professionals need to ensure that the mother and newborn will have undisturbed time to bond by minimizing the separation time spams. This can be achieved with performing the clinical examination while the newborn is on the mother’s arms, delaying the first newborn bath for after the first 24 hours, and by delaying the transfer of the mother while she is breastfeeding [50]. Rooming-in should be offered to all mothers as well as reassurance that the health professionals will be present to provide their assistance if needed, as the Family-Centered Care and the Baby-Friendly Hospital Initiative (BFHI) recommends [72]. Mothers following a cesarean birth will require more help handling their newborn, so the hospital policies should allow for a family member to be present or additional helping staff to be allocated. On the other hand, undisturbed bonding time with the newborn means that there should be a minimum number of visitors and in specified time frames during the hospital stay. Moreover, while breastfeeding there should be an indication on the door to keep people away from entering so as to preserve privacy and comfort.
4.3 Dealing with practical difficulties after a cesarean birth
In a recent qualitative study exploring the breastfeeding behavior of mothers following a cesarean birth, some of the main reported challenges for breastfeeding after a CS included the physical discomfort and the lack of knowledge and coping skills in managing their depressive mood after a CS [54]. It is important to realize that health professionals need to provide extra care and consultation to women after a CS. Women that feel greater levels of pain and discomfort are usually more easily to quit breastfeeding, as they feel that they are not able to do it properly. Health professionals need to provide encouragement, emotional support and empowerment to these women to adopt their nourishing role. They also need to provide adequate analgesia for mothers so as not to feel sore while breastfeeding [50]. It needs to be explicit that there are numerous analgesic and antibiotic drugs that are compatible with breastfeeding and women and their families need to be aware of that. At this point, it is important to comment that mothers who require anesthesia or sedation sometimes may receive inconsistent information from health care professionals regarding the passage of drugs into their breast milk. This can potentially lead to the interruption of feeding, discarding of their breast milk or early cessation of breastfeeding. A recent consensus document launched by the Association of Anesthetists and endorsed by the Royal College of Midwives and the Royal College of Obstetricians and Gynecologists clearly states that ‘breastfeeding is acceptable to continue after anesthesia and should be supported as soon as the woman is alert and able to breastfeed, and that breast milk should not be discarded’ [73].
Health professionals need to provide consultation and guidance on a more practical level such as advising on different breastfeeding positions that women may find useful and comfortable after the surgery [50]. Midwives need to assist newborns to latch on effectively, especially if they are drowsy from medication or if the mothers’ breasts are engorged after having intravenous fluids. They also need to ensure that the newborn is feeding frequently. In case the newborn cannot breastfeed directly, they should assist the mother to express her milk and provide it to her newborn, so that the milk supply will be maintained and promoted.
Another very important element for health professionals is to provide the accurate birth weight to CS newborns. Researchers propose that using newborns’ weight at 24 hours rather than the immediate weight after birth, could be a more accurate reference for weight loss and in turn could support breastfeeding by reducing supplementation rates in the absence of a clinical need. We know that fluids administered intravenously during labor due to the transplacental passage could lead to the newborn’s weight inflation immediately after a cesarean birth [74]. In a recent study, it was noted that when the 24-hour weight was used as a reference among healthy full-term newborns delivered by CS, the overall supplementation rate decreased from 43.6% pre-intervention to 27.4% post-intervention, and in first-time mothers from 51.9% to 31.0% [75]. Thus, health professionals need to take under consideration these findings and not easily attribute any newborn’s loss of weight to the lack of adequate milk supply which in turn can easily enhance maternal stress and lead to formula supplementation and no or less breastfeeding.
Women following a cesarean birth tend to face more practical difficulties with breastfeeding than women following a vaginal birth. Therefore, midwives and health professionals will need to offer ongoing support providing necessary advice and consultation on practical issues such as breastfeeding positions. Some comfortable breastfeeding positions for mothers after a cesarean birth include the following:
Lying down on the side position: This position keeps pressure away from the CS scar and is quite restful for the mother and baby, and the hand with the cannula does not pose any extra difficulties. However, the mother might need some extra help to roll over and breastfeed from the other side.
Lying back breastfeeding position: The mother is not sitting upright as she is laying backwards, and her body is supporting the baby’s weight. The baby can be put diagonally so it does not apply pressure on the wound.
Rugby ball or under the arm position: The mother uses pillows to support her back and her baby under her arm. This position also keeps the baby away from the wound.
There are many different breastfeeding positions that a mother after a cesarean birth can try while breastfeeding. The most important element is to find a comfortable position for her that she can maintain for as long as her baby wants to feed. She also needs to feel free to ask for assistance from the health personnel while in hospital and from her family members while at home. It has been mentioned in the literature that women following a cesarean birth were not feeling comfortable asking for help from the health professionals as they considered it being a sign of failure, so they tried to endure as long as they could. This eventually led to exhaustion, frustration and the decision to quit breastfeeding quite early [54].
4.4 The significance of peer support and the partner’s role
There is a growing trend on the use of social media and mothers’ support groups among new mothers to find support and guidance while breastfeeding. The WHO has recently commented in a positive manner on their effectiveness to encourage women while breastfeeding. A recent Cochrane database systematic review on interventions for promoting the initiation of breastfeeding included 107,362 women from seven countries and found low-quality evidence that healthcare professional-led breastfeeding education and non-healthcare professional-led counseling and peer support interventions can result in some improvements in the number of women beginning to breastfeed [76]. Another systematic review that tried to identify effective interventions for women having a cesarean birth to increase uptake and duration of breastfeeding, identified a limited number of effective interventions such as immediate or early skin-to-skin contact, parent education, the provision of side-bed bassinets when rooming-in, and the use of breast pumps. However, there was one study that tested a bundle intervention consisting of parent education and targeted breastfeeding support and found an increased initiation and continuation of breastfeeding [77]. Both of the above mentioned systematic reviews conclude that more research is needed to explore the effectiveness of several interventions that are initiated prior to conception or during pregnancy and postpartum.
The role of the father or partner during breastfeeding has also been supported in the literature. A quasi-experimental study in China has shown that families where fathers in the antenatal period were specifically informed about ways to support their wives with breastfeeding, maintained exclusive breastfeeding at four and six months postpartum in a larger proportion than families who received standard antenatal care [78]. A recent systematic review highlighted the value of including fathers or partners in interventions to support breastfeeding. The review showed that the inclusion of fathers or partners in breastfeeding interventions improves breastfeeding initiation, duration, and exclusivity rates. Interventions that include face-to-face information delivery, that are designed in a culturally appropriate manner, and provide information on how partners can support breastfeeding are more likely to have a beneficial effect [79]. In a recent qualitative study from Canada, it was shown that fathers themselves perceived their role as much more complex than the limited role of a breastfeeding facilitator that is usually attributed to them. They see themselves as stakeholders in decision-making on how their child is to be fed and they react to the imbalance created by breastfeeding. They want to be considered as partners during the decision-making and they acknowledge the importance of providing emotional and practical support to their breastfeeding spouses. The researchers of this study comment that health professionals need to include fathers in the parental preparation programs and should find ways to support them effectively in managing their various roles [80].
5. Conclusion
Cesarean births represent almost one third of all births globally. There is evidence showing that this medical intervention has an impact on women’s infant feeding decision and leads to important breastfeeding difficulties that involve mainly the initiation and duration of breastfeeding. The WHO promotes breastfeeding as the ideal nutrition for all newborns and infants up to the sixth month of their life, and at least up to the second year supplemented with solid foods. Health professionals can play an important role on promoting women’s breastfeeding behaviors after a cesarean section. Through high quality antenatal education programs they can assist women to change their attitudes and beliefs concerning the feasibility of breastfeeding after a CS and help them become more confident and committed. The preparation for breastfeeding after a CS should ideally start in the antenatal period. Health professionals can also implement immediate and uninterrupted skin-to-skin contact and minimize separation as the standard of care during and after an uncomplicated cesarean birth. They can also provide advice and important guidance and practical support after the birth to mothers and their family members to create a strong support network. The network of family members alongside allocated health professionals can effectively assist during the lactation process in order to ensure that both the mother and infant receive the benefits of long-term breastfeeding.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"breastfeeding, cesarean section, cesarean birth, outcomes, interventions, neonate, mode of birth",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/75696.pdf",chapterXML:"https://mts.intechopen.com/source/xml/75696.xml",downloadPdfUrl:"/chapter/pdf-download/75696",previewPdfUrl:"/chapter/pdf-preview/75696",totalDownloads:280,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 7th 2020",dateReviewed:"February 16th 2021",datePrePublished:"April 12th 2021",datePublished:"November 10th 2021",dateFinished:"March 12th 2021",readingETA:"0",abstract:"The cesarean section rates in the developed countries are well above the 5% to 15% rate of all births as suggested by the World Health Organization (WHO) in 2009 and currently range widely between 25% and 50%. Moreover, the WHO guidance promotes early breastfeeding initiation during the first hour postpartum, exclusive breastfeeding up until the 6th month and maintaining breastfeeding at least up to the second year of the infant’s life. In this review, we discuss the current evidence on whether a cesarean section interferes with the initiation and the long-term duration of breastfeeding practice among new mothers. The literature shows that a cesarean birth does have a detrimental effect on breastfeeding outcomes, however it is not per se a negative factor. It rather seems that infants who have feeding difficulties in the immediate postpartum period may experience long term problems. Therefore, interventions are discussed to promote breastfeeding after cesarean section for health professionals. Emphasis is given on promoting early skin-to-skin contact and on counseling new mothers about the advantages of breastfeeding as well as providing practical support and guidance throughout the early postpartum period.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/75696",risUrl:"/chapter/ris/75696",signatures:"Angeliki Antonakou and Dimitrios Papoutsis",book:{id:"10460",type:"book",title:"Current Topics in Caesarean Section",subtitle:null,fullTitle:"Current Topics in Caesarean Section",slug:"current-topics-in-caesarean-section",publishedDate:"November 10th 2021",bookSignature:"Panagiotis Tsikouras, Nikolaos Nikolettos, Werner Rath and Georg Friedrich Von Tempelhoff",coverURL:"https://cdn.intechopen.com/books/images_new/10460.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-179-9",printIsbn:"978-1-83969-178-2",pdfIsbn:"978-1-83969-180-5",isAvailableForWebshopOrdering:!0,editors:[{id:"48837",title:"Prof.",name:"Panagiotis",middleName:null,surname:"Tsikouras",slug:"panagiotis-tsikouras",fullName:"Panagiotis Tsikouras"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"343453",title:"Assistant Prof.",name:"Angeliki",middleName:null,surname:"Antonakou",fullName:"Angeliki Antonakou",slug:"angeliki-antonakou",email:"angelantonakou@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"346827",title:"Prof.",name:"Dimitrios",middleName:null,surname:"Papoutsis",fullName:"Dimitrios Papoutsis",slug:"dimitrios-papoutsis",email:"dpapoutsis@uowm.gr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Western Macedonia",institutionURL:null,country:{name:"Greece"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Mode of birth and the neonate",level:"1"},{id:"sec_2_2",title:"2.1 Neonatal outcomes",level:"2"},{id:"sec_3_2",title:"2.2 Alterations to the neonatal microbiome",level:"2"},{id:"sec_5",title:"3. CS and breastfeeding",level:"1"},{id:"sec_5_2",title:"3.1 The benefits of breastfeeding to the neonate and the mother",level:"2"},{id:"sec_6_2",title:"3.2 Cesarean birth and the initiation of breastfeeding",level:"2"},{id:"sec_7_2",title:"3.3 Skin-to-skin contact after a cesarean birth",level:"2"},{id:"sec_8_2",title:"3.4 Cesarean birth and the duration of breastfeeding",level:"2"},{id:"sec_10",title:"4. Effective interventions to promote early breastfeeding initiation following a cesarean birth",level:"1"},{id:"sec_10_2",title:"4.1 Prenatal preparation",level:"2"},{id:"sec_11_2",title:"4.2 The importance of adequate bonding time",level:"2"},{id:"sec_12_2",title:"4.3 Dealing with practical difficulties after a cesarean birth",level:"2"},{id:"sec_13_2",title:"4.4 The significance of peer support and the partner’s role",level:"2"},{id:"sec_15",title:"5. Conclusion",level:"1"},{id:"sec_19",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Monitoring emergency obstetric care: A handbook, Geneva: World Health Organization; 2009.'},{id:"B2",body:'WHO statement on cesarean section rates: WHO; 2019. Available from: https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/cs-statement/en/ [Accessed 2021-01-02]'},{id:"B3",body:'Ye J, Zhang J, Mikolajczyk R, Torloni MR, Gülmezoglu AM, Betrán AP. 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Effect of early skin-to-skin mother--infant contact during the first 3 hours following birth on exclusive breastfeeding during the maternity hospital stay. J Hum Lact. 2010;26(2):130-137. DOI: 10.1177/0890334409355779.'},{id:"B66",body:'Crenshaw JT, Adams ED, Gilder RE, DeButy K, Scheffer KL. Effects of Skin-to-Skin Care During cesareans: A Quasiexperimental Feasibility/Pilot Study. Breastfeed Med. 2019;14(10):731-743. DOI: 10.1089/bfm.2019.0202.'},{id:"B67",body:'Guala A, Boscardini L, Visentin R, Angellotti P, Grugni L, Barbaglia M et al. Skin-to-Skin Contact in cesarean Birth and Duration of Breastfeeding: A Cohort Study. ScientificWorldJournal. 2017;2017:1940756. DOI: 10.1155/2017/1940756.'},{id:"B68",body:'Brown A, Jordan S. Impact of birth complications on breastfeeding duration: an internet survey. J Adv Nurs. 2013;69(4):828-839. DOI: 10.1111/j.1365-2648.2012.06067.x.'},{id:"B69",body:'Pérez-Escamilla R, Maulén-Radovan I, Dewey KG. The association between cesarean delivery and breast-feeding outcomes among Mexican women. Am J Public Health. 1996 Jun;86(6):832-836. DOI: 10.2105/ajph.86.6.832.'},{id:"B70",body:'Zanardo V, Pigozzo A, Wainer G, Marchesoni D, Gasparoni A, Di Fabio S et al. Early lactation failure and formula adoption after elective cesarean delivery: Cohort study. Archives of Disease in Childhood: Fetal and Neonatal Edition. 2013;98(1). DOI: 10.1136/archdischild-2011-301218'},{id:"B71",body:'McAndrew F, Thompson J, Fellows L, Large A, Speed M, Renfrew M. Infant feeding survey 2010: Summary. Health and Social Care Information Centre. Available at http://www.hscic.gov.uk/catalogue/PUB08694 [Accessed 2021-01-05]'},{id:"B72",body:'Theo LO, Drake E. Rooming-In: Creating a Better Experience. J Perinat Educ. 2017;26(2):79-84. DOI: 10.1891/1058-1243.26.2.79'},{id:"B73",body:'Mitchell J, Jones W, Winkley E, Kinsella SM. Guideline on anaesthesia and sedation in breastfeeding women 2020. Anaesthesia 2020;75: 1482-1493. DOI: 10.1111/anae.15179.'},{id:"B74",body:'Chantry CJ, Dewey KG, Peerson JM, Wagner EA, Nommsen-Rivers LA. In-hospital formula use increases early breastfeeding cessation among first-time mothers intending to exclusively breastfeed. J Pediatr. 2014;164(6):1339-45.e5. DOI: 10.1016/j.jpeds.2013.12.035.'},{id:"B75",body:'Deng X, McLaren M. Using 24-Hour Weight as Reference for Weight Loss Calculation Reduces Supplementation and Promotes Exclusive Breastfeeding in Infants Born by cesarean Section. Breastfeed Med. 2018;13(2):128-134. DOI: 10.1089/bfm.2017.0124.'},{id:"B76",body:'Balogun OO, O\'Sullivan EJ, McFadden A, Ota E, Gavine A, Garner CD, et al. Interventions for promoting the initiation of breastfeeding. Cochrane Database Syst Rev. 2016 Nov 9;11(11):CD001688. DOI: 10.1002/14651858.CD001688.pub3.'},{id:"B77",body:'Beake S, Bick D, Narracott C, Chang YS. Interventions for women who have a cesarean birth to increase uptake and duration of breastfeeding: A systematic review. Matern Child Nutr. 2017;13(4):e12390. DOI: 10.1111/mcn.12390'},{id:"B78",body:'Su M, Ouyang YQ. Father\'s Role in Breastfeeding Promotion: Lessons from a Quasi-Experimental Trial in China. Breastfeed Med. 2016;11:144-149. DOI: 10.1089/bfm.2015.0144.'},{id:"B79",body:'Abbass-Dick J, Brown HK, Jackson KT, Rempel L, Dennis CL. Perinatal breastfeeding interventions including fathers/partners: A systematic review of the literature. Midwifery. 2019;75:41-51. DOI: 10.1016/j.midw.2019.04.001.'},{id:"B80",body:'De Montigny Fr, Gervais Ch, Larivière-Bastien D, St-Arneault K. The role of fathers during breastfeeding. Midwifery. 2018; 58: 6-12 DOI: 10.1016/j.midw.2017.12.001'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Angeliki Antonakou",address:"angelantonakou@gmail.com",affiliation:'
Midwifery Department, School of Health Science, International Hellenic University, Greece
Midwifery Department, School of Health Science, University of Western Macedonia, Greece
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The Open Access model is applied to all of our publications and is designed to eliminate subscriptions and pay-per-view fees. This approach ensures free, immediate access to full text versions of your research.
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
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Services included are:
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XML Typesetting and pagination - web (PDF, HTML) and print files preparation
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Discoverability - electronic citation and linking via DOI
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Permanent and unrestricted online access to your work
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Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
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Open Access Funding
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For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
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Added Value of Publishing with IntechOpen
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Indexing and listing across major repositories, see details ...
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Long-term archiving
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Visibility on the world's strongest OA platform
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Live Performance Metrics to track readership and the impact of your chapter
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Dissemination and Promotion
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Benefits of Publishing with IntechOpen
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Proven world leader in Open Access book publishing with over 10 years experience
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+5,700 OA books published
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Most competitive prices in the market
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Fully compliant with OA funding requirements
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Optimized processes that assure your research is made available to the scientific community without delay
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Personal support during every step of the publication process
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+184,650 citations in Web of Science databases
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Currently strongest OA platform with over 175 million downloads
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
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The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
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OAPF Publishing Options
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1,400 GBP Chapter - Edited Volume
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850 GBP Chapter - Book Series Topic (Annual Volume)
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10,000 GBP Monograph - Long Form
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4,000 GBP Compacts Monograph - Short Form
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850 GBP Journal Article (Across Portfolio)
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During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
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*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
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Services included are:
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An online manuscript tracking system to facilitate your work
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Personal contact and support throughout the publishing process from your dedicated Author Service Manager
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Assurance that your manuscript meets the highest publishing standards
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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
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XML Typesetting and pagination - web (PDF, HTML) and print files preparation
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Discoverability - electronic citation and linking via DOI
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Permanent and unrestricted online access to your work
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What isn't covered by the Open Access Publishing Fee?
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If your manuscript:
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Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
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If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
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Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
\n\n
Open Access Funding
\n\n
To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\n\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
\n\n
Added Value of Publishing with IntechOpen
\n\n
Choosing to publish with IntechOpen ensures the following benefits:
\n\n
\n\t
Indexing and listing across major repositories, see details ...
\n\t
Long-term archiving
\n\t
Visibility on the world's strongest OA platform
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Live Performance Metrics to track readership and the impact of your chapter
\n\t
Dissemination and Promotion
\n
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Benefits of Publishing with IntechOpen
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Proven world leader in Open Access book publishing with over 10 years experience
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+5,700 OA books published
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Most competitive prices in the market
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Fully compliant with OA funding requirements
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Optimized processes that assure your research is made available to the scientific community without delay
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Personal support during every step of the publication process
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+184,650 citations in Web of Science databases
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Currently strongest OA platform with over 175 million downloads
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This chapter explains how artificial intelligence and blockchain can affect the Metaverse.",book:{id:"10394",slug:"advances-in-the-convergence-of-blockchain-and-artificial-intelligence",title:"Advances in the Convergence of Blockchain and Artificial Intelligence",fullTitle:"Advances in the Convergence of Blockchain and Artificial Intelligence"},signatures:"Hyun-joo Jeon, Ho-chang Youn, Sang-mi Ko and Tae-heon Kim",authors:[{id:"342782",title:"M.A.",name:"Hyun-joo",middleName:null,surname:"Jeon",slug:"hyun-joo-jeon",fullName:"Hyun-joo Jeon"},{id:"343117",title:"BSc.",name:"Ho-chang",middleName:null,surname:"Youn",slug:"ho-chang-youn",fullName:"Ho-chang Youn"},{id:"425798",title:"Dr.",name:"Sang-mi",middleName:null,surname:"Ko",slug:"sang-mi-ko",fullName:"Sang-mi Ko"},{id:"425799",title:"Dr.",name:"Tae-heon",middleName:null,surname:"Kim",slug:"tae-heon-kim",fullName:"Tae-heon Kim"}]},{id:"65993",title:"Automatic Speech Emotion Recognition Using Machine Learning",slug:"automatic-speech-emotion-recognition-using-machine-learning",totalDownloads:4556,totalCrossrefCites:21,totalDimensionsCites:42,abstract:"This chapter presents a comparative study of speech emotion recognition (SER) systems. 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In conclusion, this chapter will become a prerequisite for other contents in the book.",book:{id:"7466",slug:"introduction-and-implementations-of-the-kalman-filter",title:"Introduction and Implementations of the Kalman Filter",fullTitle:"Introduction and Implementations of the Kalman Filter"},signatures:"Youngjoo Kim and Hyochoong Bang",authors:null},{id:"53334",title:"Cloud Computing for Next-Generation Sequencing Data Analysis",slug:"cloud-computing-for-next-generation-sequencing-data-analysis",totalDownloads:4291,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"High-throughput next-generation sequencing (NGS) technologies have evolved rapidly and are reshaping the scope of genomics research. The substantial decrease in the cost of NGS techniques in the past decade has led to its rapid adoption in biological research and drug development. Genomics studies of large populations are producing a huge amount of data, giving rise to computational issues around the storage, transfer, and analysis of the data. Fortunately, cloud computing has recently emerged as a viable option to quickly and easily acquire the computational resources for large-scale NGS data analyses. Some cloud-based applications and resources have been developed specifically to address the computational challenges of working with very large volumes of data generated by NGS technology. In this chapter, we will review some cloud-based systems and solutions for NGS data analysis, discuss the practical hurdles and limitations in cloud computing, including data transfer and security, and share the lessons we learned from the implementation of Rainbow, a cloud-based tool for large-scale genome sequencing data analysis.",book:{id:"5416",slug:"cloud-computing-architecture-and-applications",title:"Cloud Computing",fullTitle:"Cloud Computing - Architecture and Applications"},signatures:"Shanrong Zhao, Kirk Watrous, Chi Zhang and Baohong Zhang",authors:[{id:"176364",title:"Dr.",name:"Shanrong",middleName:null,surname:"Zhao",slug:"shanrong-zhao",fullName:"Shanrong Zhao"}]}],onlineFirstChaptersFilter:{topicId:"9",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81877",title:"Genetic Algorithms for Chemical Engineering Optimization Problems",slug:"genetic-algorithms-for-chemical-engineering-optimization-problems",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104884",abstract:"Chemical engineering processes are frequently composed of multiple complex phenomena. These systems can be represented by a set of several equations, which are referred to as mathematical model of the process. Optimization in chemical engineering utilizes specialized techniques to determine the values of the decision variables at which the performance of the process, measured as the objective function(s), is minimum or maximum. The profitability of the process improves remarkably as a result of this selection. This benefit has encouraged the broad application of optimization for important industrial challenges. However, many problems in chemical engineering processes are hard to find the optimum using gradient-based algorithms. For example, the cases when the objective functions of the processes are multimodal, discontinuous, or implicit. Genetic algorithms (GAs) are a kind of metaheuristic searching optimization methods, which are inspired by nature, the mechanics of natural evolution and genetics. Genetic algorithms have received significant attention due to their remarkable advantages over classical algorithms. Compared with traditional optimization approaches, GAs are straightforward, robust, capable of handling the non-differentiable, discontinuous, or multimodal problems. The purpose of this paper is to give several case studies using genetic algorithms in chemical engineering optimization problems.",book:{id:"10694",title:"Genetic Algorithms",coverURL:"https://cdn.intechopen.com/books/images_new/10694.jpg"},signatures:"Nguyen Tuan-Anh and Nguyen Thi Anh-Nga"},{id:"81827",title:"Perspective Chapter: The Importance of Pipeline in Modern Cryptosystem",slug:"perspective-chapter-the-importance-of-pipeline-in-modern-cryptosystem",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.102983",abstract:"In this digital world, all the digital information transmitted through the wireless channel has a threat to its security. Along with security, encryption speed is also a significant factor in transmitting the data as fast as possible. The pipeline is the technique used to improve the throughput of the encryption process so that the amount of data encrypted per unit time will be increased. In this chapter, the design of the modern SMS4-BSK cryptosystem is briefed, various pipeline designs of SMS4 algorithms are surveyed and the pipeline implementation on SMS4-BSK cryptosystem is analyzed. The SMS4-BSK cryptosystem is robust, fast and has a throughput of 7.4 Gbps. This modern cryptosystem can resist all kinds of cryptanalysis attacks. The pipelining technique is implemented in this cryptosystem to improve the throughput further. The pipelining method is applied in the encryption architecture of the cryptosystem. The pipelined design is implemented in Kintex-7 FPGA. The design achieved a throughput of 9.9 Gbps. The pipeline implementation can be extended to the key scheduling architecture also as both the encryption and the key scheduling use the same architecture. As per the SMS4-BSK algorithm, the keys are generated in the host system to improve the throughput.",book:{id:"11190",title:"Cryptography - Modern Theory and Practices",coverURL:"https://cdn.intechopen.com/books/images_new/11190.jpg"},signatures:"Babu M, Sathish Kumar G.A, Gurumurthy J. and Josephine Shermila P."},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.104785",abstract:"Although its origins date a few decades back, contrastive learning has recently gained popularity due to its achievements in self-supervised learning, especially in computer vision. Supervised learning usually requires a decent amount of labeled data, which is not easy to obtain for many applications. With self-supervised learning, we can use inexpensive unlabeled data and achieve a training on a pretext task. Such a training helps us to learn powerful representations. In most cases, for a downstream task, self-supervised training is fine-tuned with the available amount of labeled data. In this study, we review common pretext and downstream tasks in computer vision and we present the latest self-supervised contrastive learning techniques, which are implemented as Siamese neural networks. Lastly, we present a case study where self-supervised contrastive learning was applied to learn representations of semantic masks of images. Performance was evaluated on an image retrieval task and results reveal that, in accordance with the findings in the literature, fine-tuning the self-supervised training showed the best performance.",book:{id:"11442",title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg"},signatures:"Yalin Bastanlar and Semih Orhan"},{id:"81745",title:"Hybrid Genetic Algorithms",slug:"hybrid-genetic-algorithms",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.104735",abstract:"Hybrid optimization methods have known significant interest in recent years and are being growingly used to solve complex problems in science and engineering. For instance, the famous evolutionary Genetic Algorithm can integrate other techniques within its framework to produce a hybrid global algorithm that takes advantages of that combination and overcomes the disadvantages. Several forms of integration between Genetic Algorithms and other search and optimization techniques exist. This chapter aims to review that and present the design of a hybrid Genetic Algorithm incorporating another local optimization technique while recalling the main local search methods and emphasizing the different approaches for employing their information. A test case from the aerospace field is presented where a hybrid genetic algorithm is proposed for the mechanical sizing of a composite structure located in the upper part of a launcher.",book:{id:"10653",title:"Optimization Algorithms",coverURL:"https://cdn.intechopen.com/books/images_new/10653.jpg"},signatures:"Leila Gharsalli"},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.99853",abstract:"We investigated if general insurance claims are normal or rare events through systematic, discontinuous or sporadic jumps of the Brownian motion approach and Poisson processes. Using firm quarterly data from March 2010 to December 2018, we hypothesized that claims with high positive (negative) slopes are more likely to have large positive (negative) jumps in the future. As such, we expected salient properties of volatile jumps on the written products/contracts. We found that insurance claims for general insurance quoted products cease to be normal. There exist at times some jumps, especially during holidays and weekends. Such jumps are not healthy to the capital structures of firms, as such they need attention. However, it should be noted that gaps or jumps (unless of specific forms) cannot be hedged by employing internal dynamic adjustments. This means that, jump risk is non-diversifiable and such jumps should be given more attention.",book:{id:"10820",title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg"},signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha"},{id:"81690",title:"Your Vital Signs as Your Password?",slug:"your-vital-signs-as-your-password",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.104783",abstract:"Cognitive biometrics (vital signs) indicate the individual’s authentication using his/her mental and emotional status specifically, electrocardiogram (ECG) and electroencephalogram (EEG). The motivation behind cognitive biometrics is their uniqueness, their absolute universality in each living individual, and their resistance toward spoofing and replaying attacks in addition to their indication of life. This chapter investigates the ability to use the vital sign as unimodal authentication in its status by surveying the recent techniques, their requirements and limitation, and whether it is ready to be used in the real market or not. Our observations state—that the vital signs can be considered as a PASSWORD due to their uniqueness, but it needs more improvements to be deployed to the market.",book:{id:"11195",title:"Recent Advances in Biometrics",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg"},signatures:"Hind Alrubaish and Nazar Saqib"}],onlineFirstChaptersTotal:98},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. 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