Part of the book: Advances in Protein Kinases
The incidence of obesity is growing worldwide. In the United States, it is now estimated that one in three adults is categorized as obese. Obesity is a risk factor for multiple forms of cancer, and obese individuals have a higher risk of death. This chapter will share insight into how obesity is associated with cancer development, progression, and drug resistance by looking at the interplay between adipocytes (fat cells) and cancer cells. In particular, we will focus on alterations that occur in an obese state and biological mechanisms such as inflammation, oxidative stress, and hormonal imbalances that contribute to increased cancer risk.
Part of the book: Obesity