\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
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\r\n\tFunctional food on health maintenance and protective effects to diseases have been remarked, and their markets are rapidly increasing in the past ten years. Moreover, genome editing using the CRISPR/Cas9 method is recently applied to several foods and genome editing food is one of the remarkable topics.
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Since 2008, she has been enrolled in a Ph.D. course at the Department of Chemical Technologies of Wood and Biotechnology, Siberian State University of Science and Technology. In the same year, she began working as a junior researcher at the biotechnology laboratory of the Krasnoyarsk Agriculture Research Institute. In 2011, Dr. Savitskaya completed an internship at the University of Ottawa, Canada.",institutionString:"Institute of Bioorganic Chemistry",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Institute of Bioorganic Chemistry",institutionURL:null,country:{name:"Russia"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:[{id:"81142",title:"Is There Still Room to Improve Medicinal Herbs (Functional Herbs) by Gene Editing for Health?",slug:"is-there-still-room-to-improve-medicinal-herbs-functional-herbs-by-gene-editing-for-health",totalDownloads:37,totalCrossrefCites:0,authors:[{id:"191307",title:"Dr.",name:"Nilay",surname:"Seyidoglu",slug:"nilay-seyidoglu",fullName:"Nilay Seyidoglu"},{id:"192225",title:"Prof.",name:"Cenk",surname:"Aydin",slug:"cenk-aydin",fullName:"Cenk Aydin"}]},{id:"81313",title:"Medicinal Mushroom of Potential Pharmaceutical Toxic Importance: Contribution in Phytotherapy",slug:"medicinal-mushroom-of-potential-pharmaceutical-toxic-importance-contribution-in-phytotherapy",totalDownloads:52,totalCrossrefCites:0,authors:[null]},{id:"81904",title:"Bioactive Ingredients in Functional Foods: Current Status and Future Trends",slug:"bioactive-ingredients-in-functional-foods-current-status-and-future-trends",totalDownloads:21,totalCrossrefCites:0,authors:[null]},{id:"80675",title:"Medicinal Mushroom Mycelia: Characteristics, Benefits, and Utility in Soybean Fermentation",slug:"medicinal-mushroom-mycelia-characteristics-benefits-and-utility-in-soybean-fermentation",totalDownloads:38,totalCrossrefCites:0,authors:[null]},{id:"81122",title:"Sources and Health Benefits of Functional Food Components",slug:"sources-and-health-benefits-of-functional-food-components",totalDownloads:51,totalCrossrefCites:0,authors:[null]},{id:"81948",title:"An Overview of Functional Food",slug:"an-overview-of-functional-food",totalDownloads:23,totalCrossrefCites:0,authors:[null]},{id:"81926",title:"Mushroom; Chemistry, Bioactive Components, and Application",slug:"mushroom-chemistry-bioactive-components-and-application",totalDownloads:16,totalCrossrefCites:0,authors:[null]},{id:"81434",title:"Ginger in the Prevention of Cardiovascular Diseases",slug:"ginger-in-the-prevention-of-cardiovascular-diseases",totalDownloads:35,totalCrossrefCites:0,authors:[null]},{id:"81204",title:"Functional Foods and Antioxidant Effects: Emphasizing the Role of Probiotics",slug:"functional-foods-and-antioxidant-effects-emphasizing-the-role-of-probiotics",totalDownloads:28,totalCrossrefCites:0,authors:[{id:"197582",title:"Dr.",name:"Najaf",surname:"Allahyari Fard",slug:"najaf-allahyari-fard",fullName:"Najaf Allahyari Fard"}]},{id:"81464",title:"MIND Diet",slug:"mind-diet",totalDownloads:13,totalCrossrefCites:0,authors:[null]},{id:"80889",title:"Edible Mushrooms, a Sustainable Source of Nutrition, Biochemically Active Compounds and Its Effect on Human Health",slug:"edible-mushrooms-a-sustainable-source-of-nutrition-biochemically-active-compounds-and-its-effect-on-",totalDownloads:90,totalCrossrefCites:0,authors:[null]},{id:"81082",title:"Food as a Dietary Source of Melatonin and Its Role in Human Health: Present and Future Perspectives",slug:"food-as-a-dietary-source-of-melatonin-and-its-role-in-human-health-present-and-future-perspectives",totalDownloads:28,totalCrossrefCites:0,authors:[null]},{id:"81505",title:"Food-Based PPARγ Ligands",slug:"food-based-ppar-ligands",totalDownloads:28,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"440212",firstName:"Elena",lastName:"Vracaric",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/440212/images/20007_n.jpg",email:"elena@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Based on the most recent available data collected by the international agency for cancer, an estimated 14.1 million new cancer cases and 8.2 million cancer-related deaths occurred in 2012, compared with 12.7 million and 7.6 million, respectively, in 2008 [4].
\nThe human body is dependent on regulated cell division and elimination which forms homeostasis within the body. Certain genes play vital roles in regulating the cell cycle. These genes are grouped into three categories, tumour suppressor genes (TSGs), proto-oncogenes and DNA repair genes. Any alteration in these groups of genes downregulates the cell control mechanisms and ultimately causes cancer cell development and malignant transformation [5]. Genetic changes in the progression of cancer typically affect two different types of genes, oncogenes (e.g.,
Despite of the evolving medical significance of cancers, few studies have been conducted to identify the possible risk factors that implicated in the initiation of cancer. However, there are well-established risk factors that have been identified for its association with the development of cancer such as clinical, genetic and epidemiological factors. In addition, biological agents have been implicated in various cancers including viruses, bacteria and parasites.
\nViruses have been the most studied in their relation to tumour formation. They are thought to be associated with 15–20% of all human cancers worldwide of which about 80% are cancers of the cervix and liver [6, 7]. Viruses have evolved multiple strategies to transform host cell. One common route is to alter the expression of cellular genes by integration of the viral genome into the cellular DNA. Viruses also help cause malignancy by introducing an oncogene into a cell to disrupt the regulation of cell division [8–10].
\nInfectious agents have been implicated, either as direct carcinogens or as promoters. Viral infections, in particular, human papillomaviruses (HPVs) are recognised as carcinogenic agents in humans and are responsible for a significant share of the global cancer burden [7, 11, 12].
\nHPVs are small double-stranded DNA oncogenic viruses of approximately 8 kbp. HPVs are ubiquitous in the human population, and occasionally infection leads to cervical cancer. Although the body is working to get the infection under control, HPVs infect and disturb cutaneous and mucosal epithelial cells of the anogenital tract, hands or feet which can lead to a variety of diseases with a range of severities depending on the types of HPV infection.
\nTo date, over 100 different types of HPV have been identified, and about one-third of these infect epithelial cells in the genital tract. The type HPV family is divided into two categories: low-risk HPVs and high-risk HPVs (HR-HPVs). The low-risk HPV types such as HPV 6 and HPV 11 commonly cause benign genital warts (condylomas). These lesions can regress even without treatment [13], due to cell-mediated immune responses [14]. While the high-risk types of HPV which include HPV 16, 18, 31, 35 and 45 are associated with the development of anogenital cancers and found in up to 99% of all cervical carcinomas [15, 16]. These HR-HPV types cause benign genital epithelial hyperproliferative lesions, such as low-grade premalignant cervical intraepithelial neoplasia (CIN I). In most premalignant cases, lesions can regress even without treatment. However, in a limited number of cases, the lesions persist or progress to invasive cancer due to the lack or ineffective immunological responses.
\nIt has been reported that the low-grade CIN I would progress to high-grade lesion (CIN III) and eventually invasive cervical cancer [17]. Consequently, the associations of the HPV infection in the development of cancer are an area of ongoing interest.
\nThe papillomaviruses are small double-stranded DNA viruses which belong to the papillomaviridae family [6]. HPVs infect cutaneous or mucosal epithelial cells initiating benign or cancerous lesions that depend on the HPV types. The lifecycle, oncogenic characteristics and molecular-based evidence of HR-HPVs are suggestive of a causal role for cancer. HPV infections are normally cleared by the immune system; however, the persistence of HPV could trigger a progression to malignant lesion in the presence of other risk factors. For instance, it is well documented that the persistent infection of the cervix with HR-HPV types 16 and 18 is an initiating event of the cervical cancer [18, 19]. Therefore, the establishment, persistence of HR-HPV infection and evasion of the host immune system are necessary for premalignant lesions to initiate and progress towards squamous carcinoma [20–22].
\nThe host immune response mechanism plays a significant role in controlling and limiting HPV infection. The suppression of HPV-induced lesion depends on the host inflammatory reaction and penetration of lymphocytes to the infected tissue [14]. Thus, the prevalence of HPV-induced lesions is higher in immunosuppressed individuals such as transplant recipients or human immunodeficiency virus (HIV)-infected patients [23, 24].
\nLack of HPV clearance and persistence of viral infection for many months are necessary before the onset of an immune response. The reasons of this fact are still unknown. And perhaps one of the most important ongoing questions in the field of papillomavirus research is the latency of the host immune response in eliminating the virus in immunocompetent hosts as well as immunosuppressed hosts.
\n\nThe nonlytic feature of HPV is one of the explanations for evading the recognition of HPV infection. HPV does not lyse the infected cell or cause viremia, and this will reduce the exposure of viral antigen to cell-mediated immunity and consequent lack of inflammation. HPV life cycle characterised by the physical evasion from the immune cells’ recognition through HPV restoration and protection within infected cells’ nuclei [25, 26]. Additionally, HPV has the ability to downregulate major histocompatibility complex class I (MHC I) and disrupt the interferon (IFN) pathway. HPV facilitates this mechanism using early oncoproteins, E5, E6 and E7, which have the ability to interfere and actively participate to the downregulation of host immune system. The role of E6 and E7 is to inhibit the production of IFN in natural killer (NK) cells or the expression of transporter associated with antigen processing (TAP) [27, 28].
\nE5 oncoprotein downregulates surface MHC class I by retaining it in the Golgi apparatus (Figures 1 and 2) [20, 29]. Downregulation of MHC class 1 has been observed with E5 from different PVs, including HPV-85 and HPV-16 (Figure 3), indicating that key functions of E5 are conserved between the PV species and HPV types [21].
\nThe expression of MHC I in control and transformed PalF cells using Define FACS as “Fluorescence-activated cell sorting” (
Total and surface expression of MHC-I using FACS analysis in normal HaCaT cells transfected with pcDNA (empty vectors), pcHPV16E5, HPV83-E5a (antisense orientation) and HPV83-E5s (sense orientation) [
E5 is the smallest HPV oncogenic protein that is located in the membranes of the endoplasmic reticulum (ER) and Golgi apparatus of the transformed cells. This hydrophobic protein is a structure of 83 amino acids in HR-HPV type 16, is expressed before the onset of viral replication. E5 contribute to cell transformation through interaction with several cellular proteins, including the epidermal growth factor receptor (EGF-R), the human receptor for colony stimulating factors (CSF-1). E5 may also reduce the processing and presentation of viral antigen through the interaction with 16 kDa subunit of the vacuolar H+-ATPase acidification of endosome [30].
\nThe human MHC class I molecules are known as human leukocyte antigen (HLA) system, which have a critical function in the recognition of virally infected cells. The proteasomes and other cytoplasmic proteases are playing a role in viral protein degradation into short chain peptides of 8–10 amino acids long. HLA molecules and intracellular viral antigenic peptides complex are transported through the Golgi apparatus to the cell surface of infected cells where it is presented and recognised by the cytotoxic CD8+ T cells. The activated cytotoxic T lymphocytes (CTLs) are able to destroy the infected cell through the mechanism of apoptosis that mediated either by granulate exocytosis (perforin and granzymes) or by Fas-Fas ligand interaction [26].
\nHigh frequency of virus-specific CTLs is a characteristic of persistent viral infection such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), however low frequency of HPV-specific CTL has been detected in CIN III and cervical cancer patients [31, 32].
\nCD4+ T helper lymphocytes (Ths) are able to identify foreign antigens that presented on MHC class II molecules (antigen-MHC II complex). MHC class II molecules are mostly expressed on professional antigen presenting cells (APCs) such as dendritic cells, macrophages and B cells, but they can also be expressed on the epithelial cells (target for HPV) by IFN treatment.
\nT helper cells are capable of secreting cytokines that allow the proliferation and maintenance of cytotoxic lymphocytes. Additionally, they play a role in activation of B cells for antibody production, as well as dendritic cells for antigen presentation. Th cells potentially have an important role in cell-mediated immunity against HPV infection. The reactivity of HPV-restricted Th cells was found in patients with a persistent papillomavirus infection [33, 34].
\nWhile E6 and E7 are presented throughout the course of the HPV infection, their functions are necessary for the maintenance of a transformed status. Expression of E5 takes place in the early stage of papillomavirus infection and in the deep layers of the infected epithelium. Ashrafi et al. [29] were the first to report that E5 protein of HPV downregulates the classical HLA (A and B) but not the nonclassical HLA-E. This potentially allows the cell to escape CTL and also NK cells’ killing [20].
\nThe downregulation of MHC class I by E5 oncoprotein allows the infected cell to evade cell-mediated immune response and this potentially enables other HPV oncoproteins in the establishment and persistence of virus infection. Interestingly, it has been reported that the oncogenic E5 also inhibits the Fas receptor [35] and HLA II [36]. This strongly indicates that E5 might have additional major role in negatively regulating the immune response.
\nThe downregulation of MHC I is an imperative mechanism to evade CTL-mediated immune clearance, however, the lack of surface MHC I will activate NK cells to attack and destroy the infected cells. Human NK cells express surface receptors (NKRs) that interact with HLA class I molecules, including killer cell immunoglobulin-like receptors (KIRs) that mainly recognise classical HLA-C and also C type lectin receptors which identify nonclassical HLA-E molecule. In the absence of classical HLA-C and non-classical HLA-E, NK-mediated cell lysis would be inhibited due to the recognition of MHC class I molecules by their inhibitory receptors. Consequently, certain viruses, including HIV and CMV, have the ability to escape both CTL and NK cells’ killing. HIV-negative proteins (Nef) and CMV US3/UL40 proteins have evolved to selectively downregulate HLA (A and B), the main presenters of peptides to CTLs, but not HLA-C or nonclassical HLA-E [37, 38].
\nHR-HPV types are considered as the most important aetiological factors for many types of cancers such as cervical cancer. The risk of cervical cancer has increased in parallel with the incidence of certain genotypes of HR-HPV. Therefore, the presence of these genotypes indicates a significant risk factor for the initiation and progression of almost 90% of cervical cancer cases [18].
\nDespite the medical significance of HR-HPV infection, there is still a lack of information on the incidence of cancers that are caused by different HR-HPV genotypes in different populations. An investigation on the incidence and distribution of HR-HPV genotypes in cervical cancer patients confirmed the presence of additional high-risk types (HPV-45 and HPV-39) other than common types (HPV-16 and HPV-18) [19].
\nBeing a sexually contagious virus, HPV virus has the ability to spread through sexual and skin-to-skin contact. HR-HPVs have also been found to be the causative agents for almost up to half of vaginal, penile, anal and oral cancers. These findings suggest that HR-HPV virions might be spread from the original infected site to other organs and lead to cancer development in various organs [18].
\nTo date, studies on the role of HPV in breast carcinogenesis have generated considerable controversies and it is still not clear whether HPV infection is implicated in breast cancer pathogenesis [39]. HPV infection is a sexually transmissible disease, and most breast cancers originate from mammary duct epithelia. Therefore, the relationship between HPV and breast cancer is imperative for many reasons. The exposure of the mammary ducts to the external environment increases the risk of HPV infection. Our unpublished data have shown the presence of HR-HPV types of viral DNA other than 16 and 18 in freshly collected human breast cancer tissue and this provides a solid basis to advance research in a crucial health problem affecting women.
\nThese initial findings support the association of HPV and breast cancer and highlight possible causative agents of breast cancer. Therefore, further research is required to investigate whether HR-HPV infection plays a role in the pathogenesis of breast cancer. The information gained will pave the way to better awareness of breast cancer risk factors other than those recognised to date.
\nIdentification of HPV pathogenesis offers means of therapeutic intervention targeted against HPV oncoproteins (E5, E6 and E7) which will facilitate early lesion eradication. This will also provide results central to our understanding of HPV pathogenesis and help elucidate early events in HPV infection that may determine persistence and disease development.
\nMoreover, our findings on the presence of high-risk HPV-39 and HPV-45 types in cervical cancer other than types 16 and 18 [19] and the presence of different types of HR-HPV in breast cancer will postulate a need for further assessment of the influence of current prophylactic vaccination programs that is protective against the two most common oncogenic papillomaviruses, HPV-16 and HPV-18, but not against other high-risk mucosal HPVs detected in our studies.
\nViral carcinogenesis and cancer prevention are rapidly developing sectors of this field, and the future translation of this chapter lead to a faster resolution of HPV infection, and with obvious advantages for all HPV-affected patients, and in particular for individuals affected by early HPV-related cancer diseases.
\nChronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease worldwide, characterized by persistent airflow limitation and associated respiratory symptoms. Its pathological features are mainly chronic inflammatory changes in airway, lung parenchyma, and pulmonary vessels, which are usually associated with exposure to harmful particles and gases. Many factors, such as genetic susceptibility, abnormal inflammatory response, and abnormal lung development, are involved in the pathogenesis. In 2020, there were about 550 million (about 7.4%) COPD patients in the world, with the highest proportion of patients with COPD in Oceania (about 10.9%) and the lowest in Africa (about 5.4%) [1]. It mainly affects the population over 40 years old. Men and women are at equal risk. In 1990, COPD caused appropriate 2.4 million deaths. Until 2019, the global deaths rose to 3.23 million. About 80% of the deaths occurred in low- and middle-income countries, on the one hand, due to the high prevalence of smoking. On the other hand, it is difficult for the public and medical workers to obtain information on diagnosis and treatment management in terms of the low coverage of COPD diagnosis (69.8% in low- and middle-income countries, 98.1% in high-income countries) [2]. With the increasing smoking rate in developing countries and the aging population in high-income countries, the latest data of the World Health Organization show that the prevalence of COPD will continue to rise in the next 40 years with more than 5.4 million deaths from COPD and its related diseases annually by 2060. COPD has become an important public health problem in the world because of its high incidence, high mortality, and social and economic burden. Advances in pulmonary imaging have enabled more detailed understandings of airway and parenchymal abnormalities, and new endoscopic interventions are playing an increasingly important role in the management of advanced emphysema. At present, there is still no etiology-specific treatment for emphysema other than the addition of alpha 1 antitrypsin in patients with emphysema associated with alpha 1 antitrypsin deficiency. Further prospective studies could help clarify the role of inhaled corticosteroids in combination with dual bronchodilator therapy in the prevention of exacerbations. Compared with asthma, there is little hope for developing COPD-specific biotherapies. However, we still cannot give up investigation of COPD pathogenesis and developing scientific prevention and management methods. Therefore, this chapter focuses on the pathogenesis of COPD and the latest research advances in treatment and management of COPD.
Clinical guidelines issued by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) tend to simplify the definition of COPD. COPD is actually a heterogeneous and complex disease. Smoking is globally recognized as the most important risk factor for COPD. But data from population-based studies show that only half of COPD cases are caused by smoking. Reports from South Africa, China, and South Korea indicate that the proportion of non-smoking COPD in men and women was different, and the morbidity of non-smoking COPD in women was more than 50%, suggesting that it may be related to household smoke exposure. COPD caused by exposure to biomass fuels is quite different from smoking-induced COPD in terms of phenotype, morbidity, and disease progression. Tuberculosis infection, occupational exposure, and frequent infections in children are also considered as major risks for the development of COPD. Agriculture is also a risk factor for COPD, where pesticide exposure is associated with accelerated decline in lung function, with a reduction of 6.9 ml per year in forced expiratory volume in 1 second (FEV 1). In addition to environmental exposure, genetic risk factors are increasingly associated with the development of nicotine addiction, chronic bronchitis, loss of lung function, and early lung development.
Unregulated inflammation, oxidative/antioxidant imbalance, proteolytic/anti-proteolytic imbalance, and imbalance of cell damage/repair are recognized mechanisms. At the same time, microbiota bias, air-pollutant-related damage, and autoimmune processes in lung tissue are all underlying pathogenesis of COPD. Epigenetic regulation has also been implicated in the pathogenesis of COPD.
The pathological changes of COPD are characterized by chronic inflammation of airway, lung parenchyma, and pulmonary vessels. When the body inhales harmful particles and gases, it can cause a variety of inflammatory cells to participate in the release of a variety of inflammatory mediators, leading to irreversible lung damage. Damage to airway epithelial cells triggers a nonspecific inflammatory response through the release of endogenous intracellular molecules or risk-associated molecular patterns. These signals are recognized by pattern recognition receptors such as Toll-like receptors 4 and 2 on epithelial cells, resulting in the release of cytokines, such as TNF-α, IL-1β, granulocyte-macrophage colony-stimulating factor (GM-CSF), transforming growth factor (TGF) -β1, MCP-1, LTB 4, and IL-8. Inflammatory cells such as macrophages, neutrophils, eosinophils, and dendritic cells are recruited to sites of inflammation to form innate immune responses, while Th1, Th17, and ILC3 lymphocytes constitute acquired immunity. At the same time, activated inflammatory cells release a variety of inflammatory mediators. The mediators act on airway epithelial cells, which in turn promote epithelial cell damage. In patients with COPD, tissue damage by inflammation is uninterrupted, and the inflammatory response persists even after smoking cessation. In the case of chronic bronchitis, prolonged exposure to risk factors leads to mucosal and glandular inflammation, increased mucus secretion and epithelial cell proliferation, and altered tissue repair of the small airways.
Circulating blood cells, including neutrophils, and inflammatory cells in the lungs have long been implicated as players in smoking-induced tissue damage. Neutrophils in the sputum and bronchoalveolar lavage fluid (BALF) of patients with COPD are found to rapidly appear at sites of inflammation in response to interleukin (IL) -8, and neutrophil numbers increase with interleukin (IL) -6. A variety of other chemokines can induce neutrophil migration, including chemokines CXC motif ligand 2 (CXCL2), leukotriene B4 (LTB4), and formyl-met-leuphe (fMLP), which are produced by the body’s own immune cells and diseased tissue cells and are related to host-microbe interactions. Alpha-1-antitrypsin (AAT) is the major anti-protease, which is also a candidate chemokine for neutrophils. Neutrophils are major destroyers of the elastic matrix of the alveoli. By secreting proteases and small cationic peptides, neutrophils are able to attack invading bacteria, viruses, pollutants, and in some autoimmune situations, their own tissues. Under the influence of environmental pollution (including cigarette smoke), enzymes and peptides released by neutrophils are able to cut collagen into pieces, thereby activating inflammatory cells and driving further chronic inflammation.
Circulating progenitors of pulmonary macrophages are originated from mononuclear cells in peripheral blood. When local inflammation occurs in the airways, monocytes migrate from the circulatory system to the lung tissue and differentiate into interstitial and alveolar macrophages. Pulmonary macrophages coexist with emphysematous areas and increase in number in the airways, lung parenchyma, BALF, and sputum of patients. The number of macrophages in the airways is positively correlated with the severity of COPD. Macrophages can be activated by cigarette smoke extracts to release inflammatory mediators including tumor necrosis factor (TNF) -a, interleukin-8, other chemokines such as CXCL9, CXCL10, and CXCL11, monocyte chemotactic peptide (MCP) -1, LTb4, and reactive oxygen species. In addition, alveolar macrophages also secrete elastase including MMP-2, MMP-9, MMP-12, cathepsins K, L, and S, and neutrophil elastase extracted from neutrophils. Inflammatory proteins that are upregulated in macrophages during acute exacerbations of COPD are regulated by transcription factors such as nuclear factor-κB (NF-κB), activator protein-1, and tyrosine kinase c-Src.
T lymphocytes are present in the entire human organism including the epithelial surface of lung and mediate host defense. Human lungs are rich in resident T cells (more than 10 billion). Th1-type cells are involved in a sustained autoimmune response with interferon gamma as the primary cytokine and lead to exaggerated pro-inflammatory responses that result in uncontrolled tissue damage. Emphysema is generally considered to be a Th1 disease. Studies have shown that the development of emphysema may be mediated by T lymphocytes, and all T cell phenotypes are increased in smokers with COPD. Although neutrophils are the predominant cells in the lung parenchyma of non-COPD smokers, there is an increase in T cells (CD3 and CD8), primarily CD8 cytotoxic T cells, with evidence of emphysema. Apoptosis may be one of the mechanisms of pulmonary emphysema. In emphysema, CD8 T-cell numbers are correlated with the severity of tissue destruction, and their accumulation continues even after smoking cessation. In addition, the number of T cells was correlated with smoking history. In conclusion, the different interrelationships between T cell subtypes in COPD may be important for the progression of inflammation.
Airway eosinophilia and Th2-type inflammation are associated with allergic airway diseases such as asthma. However, recent studies have reported that 20–40% of COPD patients exhibit stable sputum eosinophilia. The SPIROMICS (SubPopulations and InteRmediate Outcome Measures In COPD Study) cohort has found that stable sputum eosinophilia is related to an increased frequency of disease exacerbations. In the meantime, high blood eosinophil levels at steady state predict a better therapeutic response to inhaled corticosteroids, which may be used to guide treatment. Although stable sputum and blood eosinophilia would be regarded as biomarkers of disease and steroid responsiveness, further work is needed to assess the importance of increased Th2 inflammation during COPD exacerbations.
ROS are oxygen-rich unstable molecules that can be either donors or acceptors of free electrons. Intracellular ROS can induce functional and structural changes in cells. The intracellular redox state is determined by the oxidant load in the respirable air and the pooling capacity of the lung protective mechanisms to absorb oxidants. Alveolar lining fluid, alveolar epithelial cells, local macrophages, and lung fibroblasts are all major targets of ROS. They can also be a secondary source of ROS. It showed that most cell types induce ROS production, and all lung cells may be involved in the redox state transition of COPD. The body keeps a dynamic balance between oxidation and antioxidation in normal condition. However, under pathological conditions, the imbalance between oxidation and antioxidation leads to oxidative stress, lipid peroxidation, protein modification, DNA damage, and activation of pro-inflammatory factors such as transcription factors NF-κB, which initiate inflammatory response and further promote oxidative stress. At the same time, the increase of oxidant can initiate the expression of antioxidant and anti-inflammatory genes through activation of nuclear factor E2-related factor (Nrf2). Therefore, antioxidant therapy may be effective in controlling and alleviating the symptoms and disease progression of COPD. Both outdoor environmental smoke and indoor airs are sources of environmental ROS. For example, laser printers can significantly increase indoor air pollution from ozone and volatile organic compounds (VOCs), and appropriate filters may reduce this pollution. In addition, office buildings are carpeted with pesticides, and the use of caustic cleaning products can produce large amounts of inhalable chemicals and particles. Aerosol spray products, air fresheners, chlorine bleaches, cleaners, dry cleaning chemicals, and furniture and floor polishes may release VOCs and other toxic substances. Therefore, it is necessary to install proper ventilation and ventilation devices.
Proteolytic enzymes have damaging and destructive effects on tissues, while anti-protease inhibits the activity of elastase. Imbalanced proteolysis is a plausible mechanism to explain the long-term persistence of emphysema. This theory partly explains the development of COPD. Proteolytic enzymes in healthy human lungs are resisted by anti-proteases. When exposed to cigarette smoke, this balance is broken and tends to proteolysis. Cigarette smoke or irritants derived from polluted air recruit inflammatory cells to produce protease 3, cathepsins L and S, MMP-2, MMP-9, and MMP-12, which are secreted primarily by neutrophils and macrophages. The anti-proteolytic barrier is composed of AAT, secretory leukocyte protease inhibitor, and tissue inhibitors of MMPs (TIMPs). Various modified forms of AAT (oxidized, aggregated, cleaved, nitrated, and citrullinated) have been implicated in inflammatory lung tissue destruction, of which proteolysis and ROS attack are major processes. Deficiency of α1-antiprotease causes an imbalance between protease and anti-protease, resulting in emphysema. In addition to proteolytic enzymes and inhibitory substances secreted by host inflammatory cells, bacterial enzymes and inhibitors should also be considered. In lung fibroblasts, elastase released by
Cell senescence is an irreversible cell cycle arrest, which is a normal physiological phenomenon. Normal aging and emphysema share common pathophysiological features including the enlargement of alveolar space and the loss of elastic recoil. The accumulation of senescent cells in the body with aging leading to a senescence-associated secretion phenotype (senescence-related secretory phenotype, SASP) induces a pro-inflammatory state, which plays an important role in various age-related diseases. At present, the mechanisms of cell aging involved in COPD include oxidative stress, telomere shortening, mitochondrial dysfunction, activation of mTOR signal transduction, reduction of antiaging molecules, stem cell failure, and DNA damage repair defects. Cell senescence usually results in reduced proliferation with unchanged metabolic activity. This leads to increase inflammation and reduce cell regeneration, a process that is further accelerated by smoking and oxidative stress. Aging affects lung structures and inflammatory cells, fibroblasts, and progenitor cells, resulting in insufficient repair and regeneration. Defective clearance of apoptotic cells in patients with emphysema contributes to the persistence of pulmonary inflammation and increases the risk of acute exacerbation. It is also one of the important reasons leading to the progressive decline of lung function in patients. Autophagy dysregulation is present in cells from COPD patients as well. Insufficient autophagy results in the accumulation of the contents of damaged cells, causing senescence. In the normal lung, autophagy maintains a balance between organelle and protein production, degradation, and recycling. In COPD lung, chronic imbalance in autophagy leads to increased tissue senescence and insufficient repair.
The common symptom of AECOPD is transient dyspnea, sputum suppuration, and increased sputum volume. Mild symptoms also occur, such as nasal obstruction, wheezing, sore throat, cough, fever, chest tightness, fatigue, insomnia, or physical activity limitation. In most cases, exacerbation in inflammatory airway is triggered by infection. Respiratory virus (rhinovirus, influenza virus, RSV, parainfluenza virus, human metapneumovirus, coronavirus, and adenovirus) infection is the main cause. Bacterial infection and environmental factors such as air pollution and ambient temperature also trigger or aggravate acute events. Meanwhile, heart failure, pneumothorax, pulmonary embolism, and anxiety cause acute exacerbation. Rhinoviruses account for 60% of exacerbations, which is the most prevalent predisposing factor. At present, it is believed that the antiviral immunity of COPD patients is impaired after respiratory viral infection, but the specific mechanism of aggravation of the disease is not fully understood. Bacteria are also extremely important in the pathogenesis of COPD exacerbations. Common species include the nontypeable
AECOPD is also characterized by abnormal airway inflammation. Traditionally, airway eosinophilia and Th2-type inflammation have been associated with allergic airway diseases such as asthma. Recent studies have found that 20–40% of patients with COPD exhibit sputum eosinophilia. The SPIROMICS (SubPopulations and InteRmediate Outcome Measures In COPD Study) cohort has found that sputum eosinophilia in stable state is associated with an increased frequency of COPD exacerbations and deteriorations. In addition, the high level of eosinophil in blood indicates a better therapeutic response to inhaled corticosteroids, which may be used to guide treatment [4]. Although stable sputum and blood eosinophilia are considered as biomarkers of disease outcome and steroid responsiveness, further work is needed to assess the importance of increased Th2 inflammation during COPD exacerbations. In contrast to non-bacterial attacks, bacterial-associated COPD exacerbations result in airway neutrophilia and release of inflammatory mediators including IL-8, leukotriene B4, and TNF-α. Macrophages and T lymphocytes are also involved in the pathogenesis of COPD exacerbation.
These mechanisms mentioned above work together to produce two major pathologies: small airway pressure elevation and emphysema, which cause persistent irreversible airflow limitation. COPD is a chronic disease with high morbidity and mortality, which is a serious threat to human health. Because of its complex etiology and pathogenesis, at present, there are still no effective targeted drugs and treatments. We should further study the cellular and molecular mechanisms in the pathogenesis of COPD in order to detect the disease early and delay disease progression.
The imbalanced proteolysis theory is also supported by data from genome-wide association studies (GWAS) and gene expression studies. Recent COPD GWAS studies identified the following genome-wide locus that is strongly associated with the risk and development of COPD, including FAM13a at 4q22, the upstream enhancer of HHIP at 4q31, IREB2 and nicotinic acetylcholine receptors (CHRNA3 and CHRNA5) o at 15q25, the 19q13 locus with RAB4B, EGLN2, and CYP2A6, RIN3 at 14q32, MMP12 at 11q22, and TGFB2 at 1q41 [5, 6, 7, 8]. Epigenetic changes includes, but are not limited to, posttranslational modifications of histones, DNA methylation, and RNA modification, which regulate gene expression without altering the gene sequence. Screening of miRNA and mRNA profiles in lung samples from smokers with or without COPD revealed that 70 miRNAs and 2667 mRNA differentially expressed. Several miRNAs, including members of the miR15/107 family, were found to regulate TGF-β signaling in COPD [9]. DNA methylation is an important regulator of gene expression, which is strongly regulated by environmental factors. DNA methylation analysis of small airway epithelia from COPD subjects found 1120 differentially methylated genes, mostly hypermethylated, which showed enrichment for three pathways: G-protein-coupled receptor signaling, arene receptor signaling, and cAMP-mediated signaling. The methylation status of 144 genes was negatively correlated with gene expression, which involved in phosphatase and tensin homolog (PTEN) signaling, the nuclear factor erythroid-derived 2-related factor 2 (also known as Nrf2) oxidative stress response, and the effect of IL-17F on allergic inflammatory diseases [10]. The emerging role of epigenetics in the development of COPD will make it possible to reprogram, minimize risk, explain causes, and create new treatments for COPD.
Patients with dyspnea, chronic cough and/or expectoration, a history of recurrent lower respiratory tract infections, and/or a history of exposure to risk factors are considered as COPD. Pulmonary function tests are necessary to confirm the diagnosis of COPD, such as forced expiratory volume in 1 second/forced vital capacity, FEV1/FVC < 0.70 after inhalation of bronchodilator, which can confirm the presence of persistent airflow limitation. Lung function assessed by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the ratio of FEV1 to FVC (FEV1/FVC) reflect the physiological state of the lung, and these indices can be used to diagnose and monitor COPD. The goal of COPD assessment is to determine the degree of airflow limitation, the impact of the disease on the patient’s health, and the risk of long-term adverse outcomes (such as AECOPD, hospitalization, or death) to guide treatment. Spirometer is an important examination instrument for the diagnosis of COPD. Clinically, it is necessary to find indicators that can predict the occurrence and development of airflow limitation and comprehensively evaluate the respiratory physiology of COPD. Alveolar diffusion is the process of gas molecules exchange through the alveolar membrane (alveolar-capillary membrane). DLco was measured by single breath method to reflect the pulmonary diffusion function. Respiratory physiological indicators other than portable pulmonary function instruments can be supplemented to better assess COPD.
Recent studies have suggested that COPD may be caused by a decreased peak and/or an accelerated decline in lung function in early adulthood. COPD can start early in life and take a long time to manifest itself clinically, so identifying “early” COPD is difficult. In addition, the biological “early” associated with the initial mechanisms that ultimately lead to COPD should be distinguished from the clinical “early,” which reflects the initial perception of symptoms, functional limitations, and/or noted structural abnormalities. Pulmonary function tests are poorly correlated with clinical characteristics and lack sufficient sensitivity for early diagnosis. Meanwhile, due to the heterogeneity and phenotypic complexity of COPD, pulmonary function measurements provide limited information on prognosis, predictive outcome, and treatment strategy, which are not sufficient for accurate diagnosis, treatment, and efficacy evaluation. Patients with COPD often suffer from cardiovascular disease, skeletal muscle dysfunction, metabolic syndrome, osteoporosis, depression, anxiety, lung cancer, and other diseases. In view of the fact that these complications are independent risk factors for hospitalization and death, we should actively look for complications and give correct treatment to patients with COPD. The development of high-throughput technologies such as genomics, proteomics, and metabolomics has provided effective tools for elucidating global changes in complex inflammatory diseases such as COPD. Among them, COPD “omics” research mainly focuses on DNA (genetic) and RNA (transcriptome) markers. The advent of mass spectrometry (MS), including gas chromatography/MS and liquid chromatography/MS, has made proteomics and metabolomics more feasible for large-scale population studies. The multi-omics integration study by similarity network fusion significantly improved the accuracy of grouping COPD patients from healthy nonsmokers to smokers with normal lung capacity, indicating that multi-omics integration data can improve the accuracy of COPD diagnosis and help promote the understanding of its pathogenesis.
Metabonomics is a comprehensive assessment of low-molecular-weight (< 1000 Da) endogenous metabolites, which can reflect biochemical reactions and metabolic changes under given physiological or pathophysiological conditions. Endogenous metabolites include a variety of small molecules such as sugars, lipids, steroids, and amino acids. The expression of these metabolites in humans represents the functional phenotype of cell, organ, or tissue. Metabonomics is of great help in identifying disease-related metabolites. Through the detection of various biological fluids (blood, urine, bronchoalveolar lavage fluid), it can provide help for the early detection of complex diseases and in-depth understanding of the pathogenesis of diseases. Smoking increases levels of nicotine and its metabolites, but also has a strong effect on the systemic metabolism of amino acids, lipids, and other small molecules. A study that recruited 211 subjects with COPD found that peripheral blood monocyte sphingolipid pathway enzyme expression and plasma small molecules such as ceramide were biomarkers of COPD and emphysema, even after adjustment for smoking. Subsequent targeted plasma metabolomics studies in 129 subjects with COPD genes further identified five sphingomyelins associated with emphysema and four trihexosylceramides and three dihexosylceramides associated with COPD exacerbations [11]. These findings support sphingolipids as potential new therapeutic targets for emphysema. Urine is also a common and available sample for metabolomics studies. Urine metabolomics is less invasive to participants than serum/plasma because serum metabolites remain relatively constant due to the balance of metabolism in the body, and urine samples are more suitable for metabolomics differential analysis than blood. Urine profiles of COPD patients and healthy controls were successfully isolated with ultrahigh performance liquid chromatography/MS (UPLC/MS)-based metabolomics. Ten metabolic biomarkers associated with COPD were identified in urine samples involving amino acid metabolism, lipid and fatty acid metabolism, and glucose metabolism. Amino acid metabolism is related to nutritional status, oxidative stress, and inflammatory response. Muscle dysfunction is an important feature of COPD patients, particularly during cachexia. In COPD patients, the concentration of histidine is increased, and muscle is synthesized by methyltransferase conversion to methylhistidine during cross-linking of actin and inosine [12]. Reduced use of histidine for muscle growth may result in increased serum histidine levels. In COPD patients, branched-chain amino acids (BCAAs) have been reduced; BCAAs regulate protein production and glucose homeostasis by continuously delivering BCAAs to skeletal muscle [13]. The reduction of BCAAs in COPD may indicate the risk of protein malnutrition. For underweight COPD patients, hypermetabolism caused by COPD exacerbation and respiratory muscle weakness is the main reason for the decline of BCAA concentration. However, the hydrolysis of muscle proteins and the consumption of branched-chain amino acids are part of the basic physiological function of providing carbon for gluconeogenesis during fasting. Cachexia patients with weight loss show increased gluconeogenesis [14], which will lead to increased consumption and decreased content of BCAAs in humans.
Proteomics aims to identify potential protein biomarkers of disease and has become a popular tool for both basic and clinical research. Proteomics has the potential to reveal some disease mechanisms that cannot be determined at the genomic level and has the great advantage of direct clinical relevance. Proteomic approaches have been used in many chronic lung diseases, such as cystic fibrosis, idiopathic pulmonary fibrosis (IPF), sarcoidosis, asthma, and so on. With the development of analysis and detection technology, the identification of potential protein biomarkers can be achieved in COPD research. Plasma proteins are involved in inflammation, coagulation regulation, lipid metabolism, and oxidative stress, and changes between healthy people and mild COPD can be evaluated at an early stage of the disease, helping us to identify early COPD. Currently, the most promising blood biomarker for COPD is sRAGE. sRAGE is an isoform of the advanced glycation end product (RAGE) transmembrane receptor that lacks a transmembrane domain through proteolytic cleavage. RAGE is encoded by the AGER gene, and SNPs in AGER have been associated with COPD and emphysema in targeted and genome-wide association studies [15]. RAGE binds damage-associated molecular pattern molecules to perpetuate inflammation in lung epithelial cells. In COPDGene, subjects with more severe emphysema had lower plasma sRAGE. The SNP in AGER (rs2070600) was associated with lower sRAGE plasma levels in COPDGene and other cohorts. Plasma sRAGE is a predictor of emphysema progressions, and it will be the first blood biomarker for emphysema to be submitted to the US Food and Drug Administration and the European Medicines Agency Biomarker Certification Program [16, 17]. While sRAGE is currently the best biomarker for emphysema, blood markers of inflammation are also associated with COPD severity and progression. In a study of 2123 subjects from COPDgene and 1117 subjects from SPIROMICS, plasma IL-6 and IL-8 were found to be positively associated with emphysema progression, but not with COPD severity and smoking status [18]. The detection of proteins in BALF and EBC can also help to clarify the pathogenesis of COPD and lung defense mechanism. In order to obtain an accurate diagnosis of COPD, an invasive approach is required in some cases. Lung tissue sample obtained by transbronchial lung biopsy or open lung biopsy procedure can also be used to analyze proteomic changes. Comparisons of lung tissues from COPD patients and healthy controls using MALDI-TOF-MS revealed significantly higher levels of matrix ferroproteinase-13 (MMP-13) and thioredoxin-like 2 in COPD patients, which may be more closely associated with the development of airflow limitation. In COPD patients, the level of SP-a in lung tissue was increased, and the level of SP-a in induced sputum supernatant was increased, but the levels of other surfactant proteins (SP-B, SPC, SP-D) were not changed. These results suggest that SP-a may be involved in the pathogenesis of COPD. However, the determination of a protein as a biomarker requires a large amount of sample data as a basis. We still have a lot of work to do.
The aim of transcriptome analysis is to capture coding and non-coding RNAs and quantify the heterogeneity of gene expression in cells, tissues, organs, and even the whole body. Transcriptomics can provide functional characterization and annotation of genes/genomes previously revealed by DNA sequencing [19]. Currently, three transcriptomics-related technologies are employed, including real-time quantitative PCR (qPCR), microarray, and RNA sequencing. The sample sources for the COPD transcriptomics study were focused on peripheral blood, lung tissue, and sputum. Similar to the epigenome, the transcriptome can be influenced by factors such as age, gender, cell type, environmental exposure, and disease status. For example, a study conducted microarray gene expression profiling of peripheral blood mononuclear cells collected from 136 COPDGene subjects and found that 1090 transcripts associated with FEV 1% prediction and 1745 transcripts associated with FEV 1/FVC, genes that overrepresent pathways associated with immunity, inflammatory response, and sphingolipid (ceramide) metabolism and signaling. At single cell level, COPD was found to be associated with a decreased ratio of specific transcriptome features of CD4+ resting memory cells and naive B cells [20]. There are also studies using gene expression profiling of lung tissue to explore the molecular pathogenesis of early COPD with emphysema. RNASeq was used to detect 16,676 genes expressed in lung tissue. Among them, 1226 genes in the COPD group with emphysema and 434 genes in the non-emphysema group were differentially expressed with healthy smokers [21]. Xiao et al. explored the relationship between gene transcriptomics and several single-nucleotide polymorphisms in sputum. Distal gene loci and biomarker encoding genes may influence circulating levels of COPD-associated pneumonia proteins, and a subset of these protein quantitative trait loci may influence their susceptibility in the lung and/or COPD. A notable feature of transcriptomics research is that the number of potential transcription variables is usually very large, and special methods are needed to deal with the huge and disordered data. For example, the weighted gene co-expression network and clustering method can be used to reduce the dimensionality.
COPD exacerbations are highly heterogeneous events associated with increased airway and systemic inflammation and physiologic changes, and reliable and objective biomarkers are invaluable to aid diagnosis and guide appropriate treatment. In blood, urine, breath samples (including exhaled breath, sputum, bronchoalveolar lavage fluid, and bronchial biopsies), levels of various immune inflammatory cells and molecules are elevated, such as CRP, PCT, BNP, plasma fibrinogen, IL-6, sputum eosinophilia, IL1β, CXCL10 (IP-10), some of which have been used in clinical examinations to assist in the evaluation of COPD deterioration [22]. At present, the research on the pathogenesis of AECOPD is still insufficient, and there are contradictory conclusions. In recent years, the widespread use of high-throughput sequencing technology has enabled us to study COPD in greater depth. At the metabolomics level, newly discovered markers of differential metabolism may be associated with disease states; at the proteomics level, several disease-related proteins have been identified and are expected to be used in the early diagnosis of COPD, while in transcriptomics, some biomarkers may be used to evaluate the prognosis of the disease. In general, multi-omics studies provide a way to discover biomarkers for early diagnosis of COPD, but the identified prospective biomarkers need to be clinically validated for early diagnosis of COPD. Therefore, clinicians need to collect a large number of patient data and clinical samples. Only by combining proteomics, transcriptomics, metabolomics, and bioinformatics, can we obtain reliable and helpful results for clinical diagnosis and treatment.
Smoking cessation is the first step in the treatment of COPD and the key to reducing the progressive decline of lung function. Lung function and smoking-related comorbidities (lung cancer and cardiovascular disease) increase mortality rate over time in COPD patients. Cooking with stoves instead of open fires can reduce the progressive decline in lung function by reducing indoor air pollution in a manner similar to smoking cessation. It is different for COPD patients with high tobacco dependence to smoking cessation. Thus, up to 40% of patients, even those with severe COPD, are persistent smokers. Drug therapy and nicotine replacement therapy can improve long-term abstinence rates. Smoking legislation and counseling by medical professionals can also improve abstinence rates. Currently, the effectiveness and safety of e-cigarettes as a smoking cessation aid are uncertain.
Increasing physical activity of daily living is as important as smoking cessation in reducing morbidity and mortality rate in COPD patients. In the early stage of the disease, lack of physical activity is closely related to hospitalization and mortality. In COPD patients, walking for 15 minutes per day reduced the risk of death by 14%, and an increase of 600 steps per day was associated with a lower risk of hospitalization. GOLD 2022 introduces the meta-analysis that included a total of 23 studies with 1663 participants. Compared with other groups, the mean deviation of 6 minutes walking distance (6MWD), FEV1 as a percentage of predicted values, SGRQ scores, and Chronic Respiratory Disease Questionnaire (CRQ) scores in Tai Chi group were significantly improved [23]. Tai Chi may have the potential to reduce dyspnea, improve exercise ability and quality of life in patients with COPD. Patients with COPD may benefit from practicing Tai Chi, but more effective programs need to be further studied.
“Rehabilitation 2030” is a new strategic approach to prioritizing and strengthening rehabilitation services in the health system. As part of the WHO initiative, a series of rehabilitation interventions is being developed that includes pulmonary rehabilitation for COPD. Inpatient or outpatient pulmonary rehabilitation for patients with COPD is effective in improving multiple clinically relevant outcomes. There is evidence that the core components of pulmonary rehabilitation, including exercise training combined with disease-specific education and self-management interventions, can benefit almost every COPD patient.
Pulmonary rehabilitation is an effective multidisciplinary treatment strategy that improves dyspnea, exercise tolerance, and health-related quality of life. Classical exercise programs with individualized endurance and strength training remain the cornerstone of pulmonary rehabilitation, and education to promote behavior change and self-management are also necessary for successful intervention. Tele-rehabilitation has been proposed as an alternative to traditional methods. The results of multiple trials conducted in groups and individuals with multiple tele-rehabilitation delivery platforms (videoconferencing, telephone-only, websites with telephone support, mobile applications with feedback, centralized “hubs” for people to gather) show that tele-rehabilitation is safe and has similar benefits to center-based respiratory rehabilitation in a range of outcomes [24]. However, the evidence is still evolving and best practices have not yet been established.
Medical therapy for COPD is used to reduce symptoms, decrease the frequency and severity of exacerbations, and improve exercise tolerance and health. Maintenance drug therapy in the stable phase aims to improve symptoms, improve health-related quality of life, improve exercise intolerance, and reduce the risk of deterioration. In terms of airflow restriction, reduction of air entrapment, and improvement of exercise intolerance, inhaled long-acting beta2 agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) have similar effects. LAMA tiotropium appears to be superior to LABA in preventing exacerbations and is as effective as the combination of inhaled corticosteroids and LABA. Therefore, LAMA monotherapy should be superior to LABA monotherapy in patients with a history of exacerbation. Acute exacerbations occurred significantly less during LABA-LAMA (indacaterol-glycopyrrolate) therapy than during LAMA (glycopyrrolate) monotherapy. Besides, the addition of LAMA and inhaled corticosteroids to LABA resulted in less aggravation than LABA and inhaled corticosteroids alone. Clinicians are concerned about whether further escalation from LABA-LAMA to triple therapy consisting of LABA, LAMA, and inhaled corticosteroids will provide additional benefits. Two large-scale studies found that triple therapy (LABA/LAMA/ICS) can reduce the death rate of COPD [25, 26]. For the benefit of fixed triple therapy for AECOPD, ETHOS research published evidence-based medicine evidence in the New England Journal of Medicine in June 2020. In this study, 8578 patients with chronic COPD were enrolled, aged 40 ~ 80 years, with smoking history of ≥10 packs/year, cat score ≥ 10 points, maintenance treatment with ≥2 inhalants before screening, maintenance treatment time ≥ 6 weeks, FEV1 estimated value ≥25% and < 65%, and moderate or severe AECOPD history 12 months before screening; To compare the efficacy and safety of budesonide/glulomonium bromide/formforminhaled aerosol (MDI) and dual therapy (bud/form and gly/form) with two ICs doses, all cause death was the secondary endpoint; compared with laba/lama, the use of triple therapy containing high-dose ICs (not low-dose ICs) is associated with lower mortality. The results of this study have important clinical significance, and further research or analysis may help to determine whether specific patient subgroups show greater survival benefits. The potential benefit of reducing acute exacerbation by adding inhaled corticosteroids to LABA needs to be judged and weighed the potential risk of pneumonia. When fluticasone, an inhaled corticosteroid, is added to LABA, COPD patients with low eosinophil counts may have an increased risk of pneumonia. This suggests that there is a subgroup with a high eosinophil count, and the benefits of inhaled corticosteroids outweigh the risks. Clinicians must judge whether glucocorticoid treatment needs to be combined or stopped according to the clinical symptoms, acute exacerbation risk, asthma, bronchiectasis, pulmonary tuberculosis, blood eosinophils, and other indicators of patients, and select the route, dose, and course of glucocorticoid administration according to the heterogeneity of AECOPD. Eosinophils can predict the risk of acute exacerbation, and ICS has guiding value in preventing future AECOPD. The survey data showed that the blood eosinophil count was <100 cells/μl of COPD patients who were less likely to benefit from the treatment with the treatment plan containing ICS. In addition, the presence of Proteus, Haemophilus, and increased bacterial infections and pneumonia was associated with lower blood and sputum eosinophil counts. Therefore, a lower blood eosinophil count can identify characteristic individuals of the microbiome with an increased risk of clinical deterioration caused by pathogenic bacteria. Higher blood eosinophils and lung eosinophils in COPD patients were associated with higher levels of type 2 airway inflammation markers. These differences in airway inflammation may explain the different responses of eosinophils to ICS therapy. The estimated value of eosinophil whose number is <100cells/μl and ≥ 300 cells/μl can be used to predict the different probability of treatment benefit. It should be noted that the use of eosinophils, which can predict the efficacy of ICS, should always be combined with clinical assessment of the risk of acute exacerbation. In the population with low ICS use rate, a greater decrease in FEV1 was observed in mild to moderate COPD patients with high blood eosinophil count, which indicates that blood eosinophils can be used as a biomarker of decreased lung function and are not affected by ICS use. In young persons without COPD, higher eosinophil counts were associated with an increased risk of subsequent COPD [27]. In conclusion, blood eosinophils can help clinicians evaluate the possibility of beneficial preventive response to the addition of ICS to conventional bronchodilator therapy. Therefore, blood eosinophils count can be used as biomarkers combined with clinical evaluation when making decisions about the use of ICS. In view of the increasing importance of clinical features and individualized treatment decisions, further treatment options for this subgroup should be carefully examined. Bronchodilator therapy (LABA, LAMA, or a combination of both) has been proved to be generally safe in randomized controlled trials. However, owing to these trials usually excluding patients who have severe heart disease, clinicians should be aware of the cardiac events reported in meta-analysis and observational studies. Patients reported that symptoms of chronic bronchitis may benefit from the addition of oral phosphodiesterase 4 inhibitor roflukast, especially those who have been hospitalized for COPD deterioration or have received more than two deterioration treatments in the outpatient department. Macrolide therapy is recommended for long-term and low-dose use in patients who have smoked. However, it is necessary to consider the side effects associated with propenolactone, the uncertainty of treatment for more than 1 year, and the resistance of bacteria to macrolides. The World Health Organization (WHO) has formulated the necessary intervention measures for COPD in low- and middle-income countries, and it pointed out that if the symptoms persist, low-dose theophylline can be added according to drug availability. Gold2022 suggests that FEV1 accounts for 35% ~ 60% of the estimated value, and COPD patients with smoking history are the best subjects for α 1 antitrypsin deficiency (AATD) augmentation therapy (evidence level B). The existing clinical trials and registration data are almost completely concentrated on patients with ZZ (ZZAATD/PiZZ) genotype. Recent studies have shown that the risk of mild COPD in Z gene heterozygotes is increased. Different from ZZ genotype, Z gene heterozygotes will not develop COPD in the condition of non-smoking. Therefore, it is considered that quitting smoking can prevent the development of this kind of patients [28].
There are limitations in the evidence base of drug therapy for COPD. Almost all drug treatment studies included patients who had smoked for at least 10 years and excluded patients with asthma. It is not clear how effective COPD drugs are in patients who have never smoked or who have asthma. Due to the complexity of airway inflammation and related clinical phenotypes in COPD, a single inflammatory pathway or mechanism may not be enough to continuously inhibit inflammation in all patients with COPD. Each drug treatment plan should be individualized according to the severity of COPD symptoms, the risk of acute exacerbation, adverse reactions, complications, the availability and cost of drugs, as well as the patient’s response, preference, and ability to use various drug delivery devices.
For some patients with advanced emphysema whose medical treatment is ineffective, surgery or bronchoscopic intervention may benefit. Individualized treatment decisions should be based on the characteristics of emphysema, such as heterogeneous and homogeneous, complete lobar fissure or collateral ventilation. For most patients, the therapeutic effect needs to be combined with potential complications such as pneumothorax and pneumonia. Other interventions, including hot steam or sclerotherapy, can show some efficacy, but may lead to more complications. For patients with advanced COPD, lung transplantation is still an option to improve the quality of life and exercise endurance, but it has no effect on the overall survival rate. Palliative treatment is an effective method to control the late COPD symptoms.
For patients with stable COPD and moderate decline of oxygenation index when they rest or exercise, long-term oxygen therapy should not be conducted routinely, but individual factors of patients must be considered when evaluating patients’ demand for supplemental oxygen. For patients with severe resting hypoxemia ([pao2] ≤ 55 mmHg) or moderate hypoxemia (PaO2 ≤ 60 mmHg) and signs of heart failure, pulmonary hypertension, or polycythemia, long-term oxygen therapy can improve their survival rate. The application of transnasal high flow oxygen therapy (HFNC) in the rehabilitation of COPD is a hot spot in recent years. A meta-analysis from 10 RCTs compared HFNC with conventional oxygen therapy (COT) or NIV in improving respiratory rate, FEV1, tidal volume, oxygen partial pressure, total SGRQ score, 6MWD, and exercise tolerance time [29]. The comprehensive data of six studies showed that the respiratory rate of COPD patients in HFNC group was lower. The comprehensive data of three studies showed that FEV1 of HFNC group was lower. There was no difference in tidal volume between patients with COPD in HFNC group and control group; There was no significant improvement in oxygen partial pressure between HFNC group and control group. In the subgroup analysis of HFNC and COT, the total score of SGRQ in HFNC group increased. Two multicenter RCTs showed an increase in 6MWD after HFNC, but no increase in exercise tolerance time. The differences in evidence quality included in this meta-analysis are prominent, which indicate that more high-quality RCTs are needed to verify these evidences. For patients with stable hypercapnia and high inspiratory pressure, noninvasive positive pressure ventilation aims to reduce the partial pressure of carbon dioxide (PaCO2) in arterial blood by at least 20% or lower than 6.5 kPa, which can improve the survival rate. Therefore, patients who meet the condition and have a special home care environment can consider this method.
Comorbidities affect a large part of patients with COPD. A cluster analysis was conducted on 213 COPD patients, and five unique clusters of comorbidities were established: (1) fewer comorbidities; (2) cardiovascular clusters, including hypertension and atherosclerosis, (3) cachexia clusters, including low body mass index (BMI), muscle atrophy, osteoporosis, and impairment of renal function; (4) metabolic clusters, including high BMI, dyslipidemia, hypertension, and atherosclerosis sclerosis; (5) psychological cluster, including anxiety and depression. Cardiovascular disease is a common and important complication of COPD. Although the lung function is similar, there are important differences in dyspnea and quality of life in different clusters. Systemic inflammation in cardiovascular and metabolic clusters is at a high level. Lung cancer is common in COPD patients and is the leading cause of death. The United States Preventive Services Task Force (USPSTF) updated its recommendations for lung cancer screening in 2021,which recommend that conduct LDCT annual lung cancer screening for adults aged 50 ~ 80 who have 20 packs per year of smoking history and currently smoke or quit smoking within the past 15 years [30]. Osteoporosis and depression/anxiety are common complications of COPD, which are often missed, and are related to poor health status and prognosis. Gastroesophageal reflux is associated with increased risk of AECOPD and poor health. Overall, COPD combined with other that has a great impact on the prognosis. The existence of comorbidities should not change the treatment plan of COPD, and the comorbidities should be treated according to the conventional standard, which has nothing to do with the existence of COPD. When COPD is part of a multi-disease care plan, attention should be paid to ensuring the simplicity of treatment and minimizing multidrug treatment. Some drugs for COPD have been evaluated as well as the effects of treatment outside the lung. The inhaled combination of fluticasone furoate and viranterol (an inhaled corticosteroid and a LABA) did not affect mortality or cardiovascular outcomes in patients with moderate COPD and increased risk of cardiovascular disease, but it improved cardiac insufficiency associated with hyperinflation. In a meta-analysis, there were fewer major cardiovascular events after roflukast treatment, but no randomized controlled study has been conducted to test the potential benefits of roflukast treatment on cardiovascular outcomes in COPD.
Exacerbation of COPD is an acute exacerbation of respiratory symptoms (dyspnea, cough, expectoration, and suppuration) that requires a change in treatment strategy. AECOPD can be caused by a variety of factorshe, and the most common cause is viral or bacterial respiratory tract infection. Patients are often hospitalized with dyspnea as the main symptom. The exacerbation of respiratory symptoms in COPD patients needs to be identified as AECOPD or other causes. One important differential diagnosis is pulmonary embolism (PE). In a study that included 740 AECOPD patients, 44 patients were diagnosed with PE within 48 hours after being admitted to hospital [31]. Among the 670 patients who were considered to have no venous thromboembolism and did not receive anticoagulant therapy at the time of admission, five patients developed PE during the follow-up period, of which three patients developed PE related death. The overall case fatality rate in 3 months was 6.8%. In the patients with COPD admitted due to acute deterioration of respiratory symptoms, 5.9% detected PE using predefined diagnostic algorithms. Further studies are needed to understand the possible role of systematic screening for PE in this patient population. At the same time, cardiovascular events and pneumonia also need to be excluded during acute attack. The deterioration negatively affects lung function decline, health-related quality of life, and prognosis. The treatment goal of ECOPD is to minimize the adverse effects caused by this acute exacerbation and prevent the occurrence of acute exacerbation in the future. Recommended single-use short effect β receptor agonists with or without short acting anticholinergic drugs are the initial treatment for AECOPD. Short-term systemic glucocorticoid therapy (e.g., 40 mg prednisone for 5 days) with or without short course antibiotics is the preferred treatment for acute episode events. Severe exacerbations require hospitalization and individualized treatment, including noninvasive ventilation support (preferred), oxygen therapy, treatment of associated diseases (such as heart failure, pneumonia), and finally, weaning or invasive ventilation. Cohort studies have shown that more than half of AECOPD patients have cardiovascular disease. Even without clinical symptoms of cardiac involvement, biochemical evidence of cardiac dysfunction (such as high concentration of troponin I or B-type natriuretic peptide) is common during treatment. About 20% of AECOPD may be due to the deterioration of underlying cardiovascular disease, and such patients have poor prognosis after admission. In Europe, 11% of patients died within 90 days after admission. The hospital stay of 50% of the patients was extended to 3 months; 35% of the patients were readmitted within 90 days. Gold2022 gives discharge criteria and follow-up recommendations: record the ability to perform physical activities during the follow-up of 1–4 weeks and consider whether the patient is suitable for participating in lung rehabilitation, at the same time, increasing protective measures such as wearing masks, reducing social contact, and washing hands frequently can reduce the frequency of AECOPD.
It is generally recommended that COPD patients receive influenza vaccine and pneumococcal vaccine. Influenza vaccine can reduce the incidence of lower respiratory tract infection; S. pneumoniae vaccine can reduce lower respiratory tract infection and prevent acute exacerbation of COPD. The Centers for Disease Control and prevention of the United States recommended supplementary vaccination for the patients with COPD who are not vaccinated with Tdap vaccine (dtap/dtpa) to prevent the occurrence of pertussis, tetanus, and diphtheria, in addition recommended that patients aged 50 and over with COPD should be vaccinated with herpes zoster vaccine. Novel coronavirus vaccine can effectively prevent SARS-CoV-2 infection. Patients with COPD should be vaccinated with novel coronavirus vaccine according to the national recommendations.
Due to the complex and heterogeneous COPD, there are individual differences in its clinical management. To this end, scientists have proposed a management strategy based on treatable characteristics (TTs), which can identify TTs according to their clinical characteristics (phenotype) and/or through effective biomarkers of specific pathological mechanisms (endotype) in the lung, extrapulmonary, and behavioral/environmental domains. TTs can coexist, interact, and change over time in the same patient (either spontaneously or as a result of treatment). Because TTs-guided management can improve clinical outcomes, the design of future trials for the treatment of early-onset patients needs to consider the presence or absence of TTs. Again, it is important to note that since endomorphs may differ with age, it may be different in early-onset and elderly patients, and the better understanding gained from the current study of early-onset COPD patients may provide guidance for future treatment guidelines.
Chronic obstructive pulmonary disease (COPD), as a common and heterogeneous respiratory disease, is characterized by persistent and incomplete reversible airflow limitation. Due to the heterogeneity and phenotypic complexity of COPD, traditional diagnostic methods can only provide limited predictive outcome and treatment information, which is insufficient for accurate diagnosis and evaluation. With the development of omics technology in recent years, genomics, proteomics, and metabolomics are widely used in the study of COPD, providing good tools for the discovery of biomarkers for diagnosis and elucidation of the complex mechanisms of COPD. In this chapter, based on the risk factors and causes of COPD, combined with metabolomics, proteomics, and transcriptomics studies reported in recent years, possible biomarkers for the diagnosis of COPD are summarized. It is expected to explore important metabolites and proteins involved in important pathways of COPD progression through protein-protein interaction and multi-omics analysis to explain the pathogenesis of COPD. Finally, the prospects and challenges of COPD diagnosis and treatment research are put forward. In the foreseeable future, on a global scale, COPD will remain a major public health problem. Population development in high-income countries and a significant increase in NCDs in low-income countries will accelerate this health burden, with risk factors largely unchanged. A better understanding of the genetic molecules and biology of the different endomorphs and phenotypes of this disease is needed to enable the development of innovative drugs.
This work was supported by the National Natural Science Foundation of China (81970026, 82000029), Chengdu High-level Key Clinical Specialty Construction Project (ZX20201202020), Chengdu Science and Technology Bureau (2021-YF09–00102-SN).
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Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"104",title:"Geology and Geophysics",slug:"geology-and-geophysics",parent:{id:"10",title:"Earth and Planetary Sciences",slug:"earth-and-planetary-sciences"},numberOfBooks:71,numberOfSeries:0,numberOfAuthorsAndEditors:1537,numberOfWosCitations:2111,numberOfCrossrefCitations:1263,numberOfDimensionsCitations:2742,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"104",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"11139",title:"Geochemistry and Mineral Resources",subtitle:null,isOpenForSubmission:!1,hash:"928cebbdce21d9b3f081267b24f12dfb",slug:"geochemistry-and-mineral-resources",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11139.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. 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Ismail",coverURL:"https://cdn.intechopen.com/books/images_new/10013.jpg",editedByType:"Edited by",editors:[{id:"62122",title:"Dr.",name:"Basel I.",middleName:"I.",surname:"Ismail",slug:"basel-i.-ismail",fullName:"Basel I. 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Abdel Rahman",coverURL:"https://cdn.intechopen.com/books/images_new/7747.jpg",editedByType:"Edited by",editors:[{id:"92718",title:"Prof.",name:"Rehab O.",middleName:null,surname:"Abdel Rahman",slug:"rehab-o.-abdel-rahman",fullName:"Rehab O. Abdel Rahman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9247",title:"Mineralogy",subtitle:"Significance and Applications",isOpenForSubmission:!1,hash:"5149699e666cbb61c220646173769f18",slug:"mineralogy-significance-and-applications",bookSignature:"Ali Ismail Al-Juboury",coverURL:"https://cdn.intechopen.com/books/images_new/9247.jpg",editedByType:"Edited by",editors:[{id:"58570",title:"Prof.",name:"Ali",middleName:"Ismail",surname:"Al-Juboury",slug:"ali-al-juboury",fullName:"Ali Al-Juboury"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:71,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"17663",doi:"10.5772/24120",title:"Relationships between Lithospheric Flexure, Thrust Tectonics and Stratigraphic Sequences in Foreland Setting: the Southern Apennines Foreland Basin System, Italy",slug:"relationships-between-lithospheric-flexure-thrust-tectonics-and-stratigraphic-sequences-in-foreland-",totalDownloads:3869,totalCrossrefCites:12,totalDimensionsCites:48,abstract:null,book:{id:"1297",slug:"new-frontiers-in-tectonic-research-at-the-midst-of-plate-convergence",title:"New Frontiers in Tectonic Research",fullTitle:"New Frontiers in Tectonic Research - At the Midst of Plate Convergence"},signatures:"Salvatore Critelli, Francesco Muto,\nVincenzo Tripodi and Francesco Perri",authors:[{id:"55590",title:"Prof.",name:"Salvatore",middleName:null,surname:"Critelli",slug:"salvatore-critelli",fullName:"Salvatore Critelli"},{id:"55592",title:"Prof.",name:"Francesco",middleName:null,surname:"Muto",slug:"francesco-muto",fullName:"Francesco Muto"},{id:"55593",title:"Prof.",name:"Vincenzo",middleName:null,surname:"Tripodi",slug:"vincenzo-tripodi",fullName:"Vincenzo Tripodi"},{id:"85117",title:"Dr.",name:"Francesco",middleName:null,surname:"Perri",slug:"francesco-perri",fullName:"Francesco Perri"}]},{id:"37859",doi:"10.5772/50009",title:"Plate Tectonic Evolution of the Southern Margin of Laurussia in the Paleozoic",slug:"plate-tectonic-evolution-of-the-southern-margin-of-laurussia-in-the-paleozoic",totalDownloads:5317,totalCrossrefCites:16,totalDimensionsCites:46,abstract:null,book:{id:"2227",slug:"tectonics-recent-advances",title:"Tectonics",fullTitle:"Tectonics - Recent Advances"},signatures:"Jan Golonka and Aleksandra Gawęda",authors:[{id:"16567",title:"Dr.",name:"Jan",middleName:null,surname:"Golonka",slug:"jan-golonka",fullName:"Jan Golonka"}]},{id:"17670",doi:"10.5772/20299",title:"The Qatar–South Fars Arch Development (Arabian Platform, Persian Gulf): Insights from Seismic Interpretation and Analogue Modelling",slug:"the-qatar-south-fars-arch-development-arabian-platform-persian-gulf-insights-from-seismic-interpreta",totalDownloads:9086,totalCrossrefCites:18,totalDimensionsCites:44,abstract:null,book:{id:"1297",slug:"new-frontiers-in-tectonic-research-at-the-midst-of-plate-convergence",title:"New Frontiers in Tectonic Research",fullTitle:"New Frontiers in Tectonic Research - At the Midst of Plate Convergence"},signatures:"C.R. Perotti, S. Carruba, M. Rinaldi, G. Bertozzi, L. Feltre and M. Rahimi",authors:[{id:"38310",title:"Dr.",name:"Stefano",middleName:null,surname:"Carruba",slug:"stefano-carruba",fullName:"Stefano Carruba"},{id:"42459",title:"Prof.",name:"Cesare",middleName:null,surname:"Perotti",slug:"cesare-perotti",fullName:"Cesare Perotti"},{id:"42460",title:"Dr.",name:"Marco",middleName:null,surname:"Rinaldi",slug:"marco-rinaldi",fullName:"Marco Rinaldi"},{id:"42465",title:"Dr.",name:"Giuseppe",middleName:null,surname:"Bertozzi",slug:"giuseppe-bertozzi",fullName:"Giuseppe Bertozzi"},{id:"42466",title:"Dr.",name:"Luca",middleName:null,surname:"Feltre",slug:"luca-feltre",fullName:"Luca Feltre"},{id:"42467",title:"Dr.",name:"Mashallah",middleName:null,surname:"Rahimi",slug:"mashallah-rahimi",fullName:"Mashallah Rahimi"}]},{id:"57384",doi:"10.5772/intechopen.71049",title:"A Review: Remote Sensing Sensors",slug:"a-review-remote-sensing-sensors",totalDownloads:3722,totalCrossrefCites:24,totalDimensionsCites:43,abstract:"The cost of launching satellites is getting lower and lower due to the reusability of rockets (NASA, 2015) and using single missions to launch multiple satellites (up to 37, Russia, 2014). In addition, low-orbit satellite constellations have been employed in recent years. These trends indicate that satellite remote sensing has a promising future in acquiring high-resolution data with a low cost and in integrating high-resolution satellite imagery with ground-based sensor data for new applications. These facts have motivated us to develop a comprehensive survey of remote sensing sensor development, including the characteristics of sensors with respect to electromagnetic spectrums (EMSs), imaging and non-imaging sensors, potential research areas, current practices, and the future development of remote sensors.",book:{id:"6334",slug:"multi-purposeful-application-of-geospatial-data",title:"Multi-purposeful Application of Geospatial Data",fullTitle:"Multi-purposeful Application of Geospatial Data"},signatures:"Lingli Zhu, Juha Suomalainen, Jingbin Liu, Juha Hyyppä, Harri\nKaartinen and Henrik Haggren",authors:[{id:"213512",title:"Dr.",name:"Lingli",middleName:null,surname:"Zhu",slug:"lingli-zhu",fullName:"Lingli Zhu"},{id:"213522",title:"Dr.",name:"Suomalainen",middleName:null,surname:"Juha",slug:"suomalainen-juha",fullName:"Suomalainen Juha"},{id:"213523",title:"Prof.",name:"Jingbin",middleName:null,surname:"Liu",slug:"jingbin-liu",fullName:"Jingbin Liu"},{id:"220941",title:"Prof.",name:"Juha",middleName:null,surname:"Hyyppä",slug:"juha-hyyppa",fullName:"Juha Hyyppä"},{id:"220942",title:"Prof.",name:"Harri",middleName:null,surname:"Kaartinen",slug:"harri-kaartinen",fullName:"Harri Kaartinen"},{id:"220943",title:"Prof.",name:"Henrik",middleName:null,surname:"Haggren",slug:"henrik-haggren",fullName:"Henrik Haggren"}]},{id:"60049",doi:"10.5772/intechopen.75493",title:"GNSS Error Sources",slug:"gnss-error-sources",totalDownloads:3214,totalCrossrefCites:19,totalDimensionsCites:33,abstract:"This chapter discusses the most serious sources of error affecting global navigation satellite systems (GNSS) signals, classifying these in a new way, according to their nature and/or effects. For instance, errors due to clock bias or drift are grouped together. Errors related to the signal propagation medium, too, are treated in the same way. GNSS errors need to be corrected to achieve accepted positioning and navigational accuracy. We provide a theoretical description for each source, supporting these with diagrams and analytical figures where possible. Some common metrics to measure the magnitude of GNSS errors, including the user equivalent range error (UERE) and the dilution of precision (DOP), are also presented. The chapter concludes with remarks on the significance of the sources of error.",book:{id:"6540",slug:"multifunctional-operation-and-application-of-gps",title:"Multifunctional Operation and Application of GPS",fullTitle:"Multifunctional Operation and Application of GPS"},signatures:"Malek Karaim, Mohamed Elsheikh and Aboelmagd Noureldin",authors:[{id:"227711",title:"Mr.",name:"Malek",middleName:null,surname:"Karaim",slug:"malek-karaim",fullName:"Malek Karaim"},{id:"240292",title:"Prof.",name:"Aboelmagd",middleName:null,surname:"Noureldin",slug:"aboelmagd-noureldin",fullName:"Aboelmagd Noureldin"},{id:"243124",title:"Dr.",name:"Mohamed",middleName:null,surname:"Elsheikh",slug:"mohamed-elsheikh",fullName:"Mohamed Elsheikh"}]}],mostDownloadedChaptersLast30Days:[{id:"71931",title:"Open Pit Mining",slug:"open-pit-mining",totalDownloads:1769,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Open pit mining method is one of the surface mining methods that has a traditional cone-shaped excavation and is usually employed to exploit a near-surface, nonselective and low-grade zones deposits. It often results in high productivity and requires large capital investments, low operating costs, and good safety conditions. The main topics that will be discussed in this chapter will include an introduction into the general features of open pit mining, ore body characteristics and configurations, stripping ratios and stripping overburden methods, mine elements and parameters, open pit operation cycle, pit slope angle, stability of mine slopes, types of highwall failures, mine closure and reclamation, and different variants of surface mining methods including opencast mining, mountainous mining, and artisan mining.",book:{id:"8620",slug:"mining-techniques-past-present-and-future",title:"Mining Techniques",fullTitle:"Mining Techniques - Past, Present and Future"},signatures:"Awwad H. Altiti, Rami O. Alrawashdeh and Hani M. Alnawafleh",authors:[{id:"313182",title:"Prof.",name:"Rami",middleName:null,surname:"Alrawashdeh",slug:"rami-alrawashdeh",fullName:"Rami Alrawashdeh"},{id:"313522",title:"Dr.",name:"Awwad",middleName:null,surname:"Altiti",slug:"awwad-altiti",fullName:"Awwad Altiti"},{id:"313523",title:"Prof.",name:"Hani",middleName:null,surname:"Alnawafleh",slug:"hani-alnawafleh",fullName:"Hani Alnawafleh"}]},{id:"64027",title:"Stages of a Integrated Geothermal Project",slug:"stages-of-a-integrated-geothermal-project",totalDownloads:4511,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"A geothermal project constitutes two big stages: the exploration and the exploitation. Each one has a single task whose results allow defining the feasibility of a geothermal project, until achieving the construction and operation stage of the power generation plant. The first stage contains the area recognition, its limitation to the target, and elimination of external factors until defining a geothermal zone with characteristics to be commercially exploited. The main studies and analysis that can be applied during the exploration stage are listed, and the major indicator to continue with the project or suspend is the prefeasibility report. The major risks in the exploration stage are due to studies that are carried out on the surface; at this stage, the costs can be considered low. The main results of the exploration are the selection of sites to drill three or four initial wells. Each well provides a direct overview of the reservoir: depth, production thicknesses, thermodynamic parameters, and production characteristics. The drilling of three to four exploratory wells is recommended, as far as there is certainty of the feasibility of the project, and the development of the field begins with drilling of sufficient wells to feed the plant. In this stage, the cost increases, but the risks decrease.",book:{id:"7504",slug:"renewable-geothermal-energy-explorations",title:"Renewable Geothermal Energy Explorations",fullTitle:"Renewable Geothermal Energy Explorations"},signatures:"Alfonso Aragón-Aguilar, Georgina Izquierdo-Montalvo,\nDaniel Octavio Aragón-Gaspar and Denise N. Barreto-Rivera",authors:[{id:"258358",title:"Dr.",name:"Alfonso",middleName:null,surname:"Aragón-Aguilar",slug:"alfonso-aragon-aguilar",fullName:"Alfonso Aragón-Aguilar"}]},{id:"63059",title:"Generation, Evolution, and Characterization of Turbulence Coherent Structures",slug:"generation-evolution-and-characterization-of-turbulence-coherent-structures",totalDownloads:3734,totalCrossrefCites:4,totalDimensionsCites:5,abstract:"Turbulence stands as one of the most complicated and attractive physical phenomena. The accumulated knowledge has shown turbulent flow to be composed of islands of vortices and uniform-momentum regions, which are coherent in both time and space. Research has been concentrated on these structures, their generation, evolution, and interaction with the mean flow. Different theories and conceptual models were proposed with the aim of controlling the boundary layer flow and improving numerical simulations. Here, we review the different classes of turbulence coherent structures and the presumable generation mechanisms for each. The conceptual models describing the generation of turbulence coherent structures are generally classified under two categories, namely, the bottom-up mechanisms and the top-down mechanisms. The first assumes turbulence to be generated near the surface by some sort of instabilities, whereas the second assigns an active role to the large outer layer structures, perhaps the turbulent bulges. Both categories of models coexist in the flow with the first dominating turbulence generation at low Reynolds number and the second at high Reynolds number, such as the case in the atmospheric boundary layer.",book:{id:"7214",slug:"turbulence-and-related-phenomena",title:"Turbulence and Related Phenomena",fullTitle:"Turbulence and Related Phenomena"},signatures:"Zambri Harun and Eslam Reda Lotfy",authors:[{id:"243152",title:"Dr.",name:"Zambri",middleName:null,surname:"Harun",slug:"zambri-harun",fullName:"Zambri Harun"},{id:"252195",title:"Dr.",name:"Eslam",middleName:null,surname:"Reda",slug:"eslam-reda",fullName:"Eslam Reda"}]},{id:"64562",title:"Electrical Resistivity Tomography: A Subsurface-Imaging Technique",slug:"electrical-resistivity-tomography-a-subsurface-imaging-technique",totalDownloads:3225,totalCrossrefCites:8,totalDimensionsCites:12,abstract:"Electrical resistivity tomography (ERT) is a popular geophysical subsurface-imaging technique and widely applied to mineral prospecting, hydrological exploration, environmental investigation and civil engineering, as well as archaeological mapping. This chapter offers an overall review of technical aspects of ERT, which includes the fundamental theory of direct-current (DC) resistivity exploration, electrode arrays for data acquisition, numerical modelling methods and tomographic inversion algorithms. The section of fundamental theory shows basic formulae and principle of DC resistivity exploration. The section of electrode arrays summarises the previous study on all traditional-electrode arrays and recommends 4 electrode arrays for data acquisition of surface ERT and 3 electrode arrays for cross-hole ERT. The section of numerical modelling demonstrates an advanced version of finite-element method, called Gaussian quadrature grid approach, which is advantageous to a numerical simulation of ERT for complex geological models. The section of tomographic inversion presents the generalised standard conjugate gradient algorithms for both the l1- and l2-normed inversions. After that, some synthetic and real imaging examples are given to show the near-surface imaging capabilities of ERT.",book:{id:"8361",slug:"applied-geophysics-with-case-studies-on-environmental-exploration-and-engineering-geophysics",title:"Applied Geophysics with Case Studies on Environmental, Exploration and Engineering Geophysics",fullTitle:"Applied Geophysics with Case Studies on Environmental, Exploration and Engineering Geophysics"},signatures:"Bing Zhou",authors:null},{id:"17670",title:"The Qatar–South Fars Arch Development (Arabian Platform, Persian Gulf): Insights from Seismic Interpretation and Analogue Modelling",slug:"the-qatar-south-fars-arch-development-arabian-platform-persian-gulf-insights-from-seismic-interpreta",totalDownloads:9083,totalCrossrefCites:18,totalDimensionsCites:43,abstract:null,book:{id:"1297",slug:"new-frontiers-in-tectonic-research-at-the-midst-of-plate-convergence",title:"New Frontiers in Tectonic Research",fullTitle:"New Frontiers in Tectonic Research - At the Midst of Plate Convergence"},signatures:"C.R. 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He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"1",type:"subseries",title:"Oral Health",keywords:"Oral Health, Dental Care, Diagnosis, Diagnostic Imaging, Early Diagnosis, Oral Cancer, Conservative Treatment, Epidemiology, Comprehensive Dental Care, Complementary Therapies, Holistic Health",scope:"\r\n\tThis topic aims to provide a comprehensive overview of the latest trends in Oral Health based on recent scientific evidence. Subjects will include an overview of oral diseases and infections, systemic diseases affecting the oral cavity, prevention, diagnosis, treatment, epidemiology, as well as current clinical recommendations for the management of oral, dental, and periodontal diseases.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11397,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). 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