Hon-Chiu Leung

Assistant ProfessorBaylor College of MedicineUnited States of America

Dr Hon-Chiu Eastwood Leung finished his Ph.D. Degree in microbiology and molecular genetics from University of Texas, Houston in 1997. He did his post-doctoral training in Baylor College of Medicine studying genomics and proteomics profiles of pediatrics medulloblastoma and osteosarcoma. Dr. Leung was a research scientists in Ciphergen Biosystems Inc. Briefly, and then was recruited to Genome Institute of Singapore to lead the clinical proteomics section. In 2006 he returned to USA. He was the director of the genomics and proteomics core laboratory of the Texas Children´s Hospital and director of genomics profiling of Baylor College of Medicine. At present, he is the director of the mass spectrometry-proteomics core facility of Baylor College of Medicine.

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Latest work with IntechOpen by Hon-Chiu Leung

Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field.

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