Zuzana Storchova

Zuzana Storchova received her Ph.D. in Molecular Genetics at the Charles University in Prague, Czech Republic. She than continued working on mechanisms of DNA repair at the University of Zurich, Switzerland, in the laboratory of Prof. J. Jiricny. Her postdoctoral work in the laboratory of Prof. D. Pellman at the Dana-Farber Cancer Institute/Harvard Medical School in Boston, USA, focused on the consequences of polyploidy in budding yeast. Zuzana Storchova joined the Max Planck Institute of Biochemistry in Martinsried, Germany, in 2008. There she established a research group with the main focus on uncovering the causes and consequences of polyploidy and aneuploidy in yeast and human cells.

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Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies.

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