\r\n\t
",isbn:"978-1-83969-558-2",printIsbn:"978-1-83969-557-5",pdfIsbn:"978-1-83969-559-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"97b6de623f15598880112f6bafedc3e1",bookSignature:"Dr. Robert M.X. Wu",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11916.jpg",keywords:"Business Models, E-commerce Marketing Strategy, E-commerce Business Models, Digital Transformation, Business Intelligence, E-business Applications, Research, Information System Management, Marketing Management, Electronic Commerce, Internet Marketing, Information Systems",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 26th 2022",dateEndSecondStepPublish:"June 30th 2022",dateEndThirdStepPublish:"August 29th 2022",dateEndFourthStepPublish:"November 17th 2022",dateEndFifthStepPublish:"January 16th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"7 hours",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:'Dr. Wu holds a Ph.D. in e-Commerce, lectures at the School of Engineering and Technology in Australia, and is a Distinguished Professor at Shanxi Normal University, China. In 2011, Dr. Wu was recognized as a ‘Top 100 Outstanding Academic Leader for China’s Informatics’ by the China Informatics Society. He was awarded "Outstanding Contribution in Reviewing" by Q1 Journals such as Electronic Commerce Research and Applications (Elsevier).',coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"190913",title:"Dr.",name:"Robert M.X.",middleName:null,surname:"Wu",slug:"robert-m.x.-wu",fullName:"Robert M.X. Wu",profilePictureURL:"https://mts.intechopen.com/storage/users/190913/images/system/190913.jpg",biography:"Robert M.X. Wu has a diploma in Computer Science, a bachelor’s degree in Economics, and master’s and doctorate degrees in e-Commerce. He is currently lecturing e-commerce / Information Systems at Central Queensland University Australia (CQU). He has led more than ten industry-based research projects since 2012 and contributes to reviewing five A-level Australian Business Deans Council (ABDC) journals and Q1 journals.\r\nIn July 2011, Dr. Wu was recognized as a ‘Top 100 Outstanding Academic Leader for China’s Informatics’ by the China Informatics Society. In 2017 he was appointed Distinguished Professor at Shanxi Normal University, China. He was also awarded ‘Outstanding Contribution in Reviewing’ in 2016 and 2018 by the Electronic Commerce Research and Applications journal (Elsevier) and ‘Student Voice Commendation – EDUCATORS of THE YEAR 2020’ for Emerging Technologies in E-Business, CQU.",institutionString:"Central Queensland University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Central Queensland University",institutionURL:null,country:{name:"Australia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"9",title:"Computer and Information Science",slug:"computer-and-information-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"440204",firstName:"Ana",lastName:"Cink",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/440204/images/20006_n.jpg",email:"ana.c@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"10302",title:"A Complete Practical Ultra Wideband Test Bed in X-Band",doi:"10.5772/9011",slug:"a-complete-practical-ultra-wideband-test-bed-in-x-band",body:null,keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/10302.pdf",chapterXML:null,downloadPdfUrl:"/chapter/pdf-download/10302",previewPdfUrl:"/chapter/pdf-preview/10302",totalDownloads:3145,totalViews:62,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:18,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:null,dateReviewed:null,datePrePublished:null,datePublished:"March 1st 2010",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/10302",risUrl:"/chapter/ris/10302",book:{id:"3708",slug:"microwave-and-millimeter-wave-technologies-modern-uwb-antennas-and-equipment"},signatures:"Gholamreza Askari, Khatereh Ghasemi and Hamid Mirmohammad Sadeghi",authors:null,sections:null,chapterReferences:null,footnotes:null,contributors:null,corrections:null},book:{id:"3708",type:"book",title:"Microwave and Millimeter Wave Technologies",subtitle:"Modern UWB antennas and equipment",fullTitle:"Microwave and Millimeter Wave Technologies Modern UWB antennas and equipment",slug:"microwave-and-millimeter-wave-technologies-modern-uwb-antennas-and-equipment",publishedDate:"March 1st 2010",bookSignature:"Igor Minin",coverURL:"https://cdn.intechopen.com/books/images_new/3708.jpg",licenceType:"CC BY-NC-SA 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-7619-67-1",pdfIsbn:"978-953-51-6420-3",reviewType:"peer-reviewed",numberOfWosCitations:22,isAvailableForWebshopOrdering:!0,editors:[{id:"123258",title:"Dr.",name:"Igor",middleName:null,surname:"Minin",slug:"igor-minin",fullName:"Igor Minin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"750"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"10301",type:"chapter",title:"Directive Ultra-Wideband Planar Antennas",slug:"directive-ultra-wideband-planar-antennas",totalDownloads:4824,totalCrossrefCites:1,signatures:"A.-D. Capobianco, F.M. Pigozzo, A. Locatelli, D. Modotto, C. De Angelis, S. Boscolo, F. Sacchetto, M. Midrio",reviewType:"peer-reviewed",authors:[null]},{id:"10306",type:"chapter",title:"Ultra-Wideband Antenna",slug:"ultra-wideband-antenna",totalDownloads:7203,totalCrossrefCites:5,signatures:"Cheolbok Kim",reviewType:"peer-reviewed",authors:[null]},{id:"10307",type:"chapter",title:"Patch Antennas and Microstrip Lines",slug:"patch-antennas-and-microstrip-lines",totalDownloads:23019,totalCrossrefCites:1,signatures:"John R. Ojha and Marc Peters",reviewType:"peer-reviewed",authors:[null]},{id:"10299",type:"chapter",title:"UWB and SWB Planar Antenna Technology",slug:"uwb-and-swb-planar-antenna-technology",totalDownloads:4823,totalCrossrefCites:0,signatures:"Shun-Shi Zhong",reviewType:"peer-reviewed",authors:[null]},{id:"10302",type:"chapter",title:"A Complete Practical Ultra Wideband Test Bed in X-Band",slug:"a-complete-practical-ultra-wideband-test-bed-in-x-band",totalDownloads:3145,totalCrossrefCites:0,signatures:"Gholamreza Askari, Khatereh Ghasemi and Hamid Mirmohammad Sadeghi",reviewType:"peer-reviewed",authors:[null]},{id:"10308",type:"chapter",title:"Novel Polarization-Agile Annular Waveguide Slot Antennas",slug:"novel-polarization-agile-annular-waveguide-slot-antennas",totalDownloads:2910,totalCrossrefCites:0,signatures:"Siamak Ebadi and Keyvan Forooraghi",reviewType:"peer-reviewed",authors:[null]},{id:"10311",type:"chapter",title:"Reconfigurable Radiation Pattern Antennas in mm-Waves",slug:"reconfigurable-radiation-pattern-antennas-in-mm-waves",totalDownloads:4567,totalCrossrefCites:0,signatures:"Olivier Lafond, M. Caillet, B. Fuchs and M. Himdi",reviewType:"peer-reviewed",authors:[null]},{id:"10300",type:"chapter",title:"Characteristics of High-Gain Wideband Ring Loop Antenna and its Application",slug:"characteristics-of-high-gain-wideband-ring-loop-antenna-and-its-application",totalDownloads:4898,totalCrossrefCites:0,signatures:"Haruo Kawakami",reviewType:"peer-reviewed",authors:[null]},{id:"10304",type:"chapter",title:"Antenna Array Design in Aperture Synthesis Radiometers",slug:"antenna-array-design-in-aperture-synthesis-radiometers",totalDownloads:4380,totalCrossrefCites:4,signatures:"Jian Dong and Qingxia Li",reviewType:"peer-reviewed",authors:[null]},{id:"10314",type:"chapter",title:"Antenna Measurement",slug:"antenna-measurement",totalDownloads:6351,totalCrossrefCites:1,signatures:"Dominique Picard",reviewType:"peer-reviewed",authors:[null]},{id:"10317",type:"chapter",title:"The Interference between Ground Plane and Receiving Antenna and its Effect on the Radiated EMI Measurement Uncertainty",slug:"the-interference-between-ground-plane-and-receiving-antenna-and-its-effect-on-the-radiated-emi-measu",totalDownloads:3867,totalCrossrefCites:0,signatures:"Mikulas Bittera, Viktor Smiesko, Karol Kovac and Jozef Hallon",reviewType:"peer-reviewed",authors:[null]},{id:"10310",type:"chapter",title:"Analysis of Directive Sensor Influence on Array Beampatterns",slug:"analysis-of-directive-sensor-influence-on-array-beampatterns",totalDownloads:1661,totalCrossrefCites:4,signatures:"Lara del Val, Alberto Izquierdo, Maria I. Jimenez, Juan J. Villacorta and Mariano Raboso",reviewType:"peer-reviewed",authors:[{id:"3646",title:"Dr.",name:"Mariano",middleName:null,surname:"Raboso Mateos",fullName:"Mariano Raboso Mateos",slug:"mariano-raboso-mateos"},{id:"4377",title:"Dr.",name:"Lara",middleName:null,surname:"Del Val",fullName:"Lara Del Val",slug:"lara-del-val"},{id:"111759",title:"Dr.",name:"María Isabel",middleName:null,surname:"Jiménez",fullName:"María Isabel Jiménez",slug:"maria-isabel-jimenez"},{id:"111760",title:"Dr.",name:"Alberto",middleName:null,surname:"Izquierdo",fullName:"Alberto Izquierdo",slug:"alberto-izquierdo"},{id:"111761",title:"Dr.",name:"Juan José",middleName:null,surname:"Villacorta",fullName:"Juan José Villacorta",slug:"juan-jose-villacorta"}]},{id:"10312",type:"chapter",title:"Millimeter-Wave Radio over Fiber System for Broadband Wireless Communication",slug:"millimeter-wave-radio-over-fiber-system-for-broadband-wireless-communication",totalDownloads:4314,totalCrossrefCites:0,signatures:"Haoshuo Chen, Rujian Lin and Jiajun Ye",reviewType:"peer-reviewed",authors:[null]},{id:"10309",type:"chapter",title:"Measurement and Modeling of Rain Intensity and Attenuation for the Design and Evaluation of Microwave and Millimeter-Wave Communication Systems",slug:"measurement-and-modeling-of-rain-intensity-and-attenuation-for-the-design-and-evaluation-of-microwav",totalDownloads:2810,totalCrossrefCites:3,signatures:"Gamantyo Hendrantoro, Akira Matsushima",reviewType:"peer-reviewed",authors:[null]},{id:"10318",type:"chapter",title:"High-Temporal Global Rainfall Maps from Satellite Passive Microwave Radiometers",slug:"high-temporal-global-rainfall-maps-from-satellite-passive-microwave-radiometers",totalDownloads:2598,totalCrossrefCites:0,signatures:"Shoichi Shige, Satoshi Kida, Tomoya Yamamoto, Takuji Kubota and Kazumasa Aonashi",reviewType:"peer-reviewed",authors:[null]},{id:"10297",type:"chapter",title:"A Dual-Frequency Metallic Waveguide System",slug:"a-dual-frequency-metallic-waveguide-system",totalDownloads:2092,totalCrossrefCites:0,signatures:"Yoshihiro Kokubo",reviewType:"peer-reviewed",authors:[null]},{id:"10298",type:"chapter",title:"Applications of On-Chip Coplanar Waveguides to Design Local Oscillators for Wireless Communications System",slug:"applications-of-on-chip-coplanar-waveguides-to-design-local-oscillators-for-wireless-communications-",totalDownloads:2928,totalCrossrefCites:0,signatures:"Ramesh K. Pokharel, Haruichi Kanaya and Keiji Yoshida",reviewType:"peer-reviewed",authors:[null]},{id:"10305",type:"chapter",title:"Design Techniques for Microwave and Millimeter Wave CMOS Broadband Amplifiers",slug:"design-techniques-for-microwave-and-millimeter-wave-cmos-broadband-amplifiers",totalDownloads:4375,totalCrossrefCites:0,signatures:"Shawn S. H. Hsu and Jun-De Jin",reviewType:"peer-reviewed",authors:[null]},{id:"10313",type:"chapter",title:"Multi-Port Technology and Applications",slug:"multi-port-technology-and-applications",totalDownloads:3190,totalCrossrefCites:1,signatures:"Moldovan Emilia, Bosisio G. Renato, Wu Ke and Tatu Serioja O.",reviewType:"peer-reviewed",authors:[null]},{id:"10316",type:"chapter",title:"Wideband Representation of Passive Components Based on Planar Waveguide Junctions",slug:"wideband-representation-of-passive-components-based-on-planar-waveguide-junctions",totalDownloads:2137,totalCrossrefCites:0,signatures:"Fermin Mira, Angel A. San Blas, Vicente E. Boria and Benito Gimeno",reviewType:"peer-reviewed",authors:[null]},{id:"10303",type:"chapter",title:"Study and Application of Microwave Active Circuits with Negative Group Delay",slug:"study-and-application-of-microwave-active-circuits-with-negative-group-delay",totalDownloads:2061,totalCrossrefCites:1,signatures:"Blaise Ravelo, Andre Perennec and Marc Le Roy",reviewType:"peer-reviewed",authors:[null]},{id:"10319",type:"chapter",title:"Broadband GaN MMIC Power Amplifiers design",slug:"broadband-gan-mmic-power-amplifiers-design",totalDownloads:6706,totalCrossrefCites:0,signatures:"Maria-Angeles Gonzalez-Garrido and Jesus Grajal",reviewType:"peer-reviewed",authors:[null]},{id:"10315",type:"chapter",title:"Magnetron Based Radar Systems for Millimeter Wavelength Band – Modern Approaches and Prospects",slug:"magnetron-based-radar-systems-for-millimeter-wavelength-band-modern-approaches-and-prospects",totalDownloads:5717,totalCrossrefCites:1,signatures:"Vadym Volkov",reviewType:"peer-reviewed",authors:[null]}]},relatedBooks:[{type:"book",id:"3707",title:"Microwave and Millimeter Wave Technologies",subtitle:"from Photonic Bandgap Devices to Antenna and Applications",isOpenForSubmission:!1,hash:null,slug:"microwave-and-millimeter-wave-technologies-from-photonic-bandgap-devices-to-antenna-and-applications",bookSignature:"Igor Minin",coverURL:"https://cdn.intechopen.com/books/images_new/3707.jpg",editedByType:"Edited by",editors:[{id:"123258",title:"Dr.",name:"Igor",surname:"Minin",slug:"igor-minin",fullName:"Igor Minin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"10357",title:"Trend on Silicon Technologies for Millimetre-Wave Applications up to 220 GHz",slug:"trend-on-silicon-technologies-for-millimetre-wave-applications-up-to-220-ghz",signatures:"Gaetan Prigent, Thanh Mai Vu, Eric Rius and Robert Plana",authors:[null]},{id:"10341",title:"Integrated Silicon Microwave and Millimeterwave Passive Components and Functions",slug:"integrated-silicon-microwave-and-millimeterwave-passive-components-and-functions",signatures:"Philippe Benech, Jean-Marc Duchamp, Philippe Ferrari, Darine Kaddour, Emmanuel Pistono, Tan Phu Vuong, Pascal Xavier and Christophe Hoarauand Jean-Daniel Arnould",authors:[null]},{id:"10356",title:"Negative Refractive Index Composite Metamaterials for Microwave Technology",slug:"negative-refractive-index-composite-metamaterials-for-microwave-technology",signatures:"Nicola Bowler",authors:[null]},{id:"10352",title:"Dielectric Anisotropy of Modern Microwave Substrates",slug:"dielectric-anisotropy-of-modern-microwave-substrates",signatures:"Plamen I. Dankov",authors:[null]},{id:"10342",title:"Application of Meta-Material Concepts",slug:"application-of-meta-material-concepts",signatures:"Ho-Yong Kim and Hong-Min Lee",authors:[null]},{id:"10343",title:"Microwave Filters",slug:"microwave-filters",signatures:"Jiafeng Zhou",authors:[null]},{id:"10347",title:"Reconfigurable Microwave Filters",slug:"reconfigurable-microwave-filters",signatures:"Ignacio Llamas-Garro and Zabdiel Brito-Brito",authors:[null]},{id:"10339",title:"Electronically Tunable Ferroelectric Devices for Microwave Applications",slug:"electronically-tunable-ferroelectric-devices-for-microwave-applications",signatures:"Stanis Courreges, Zhiyong Zhao, Kwang Choi, Andrew Hunt and John Papapolymerou",authors:[null]},{id:"10344",title:"Advanced RF MOSFET´s for Microwave and Millimeter Wave Applications: RF Characterization Issues",slug:"advanced-rf-mosfet-s-for-microwave-and-millimeter-wave-applications-rf-characterization-issues",signatures:"Julio C. Tinoco and Jean-Pierre Raskin",authors:[null]},{id:"10353",title:"Development of Miniature Microwave Components by Using High Contrast Dielectrics",slug:"development-of-miniature-microwave-components-by-using-high-contrast-dielectrics",signatures:"Elena Semouchkina",authors:[null]},{id:"10355",title:"Broadband and Planar Microstrip-to-Waveguide Transitions",slug:"broadband-and-planar-microstrip-to-waveguide-transitions",signatures:"Kunio Sakakibara",authors:[null]},{id:"10354",title:"Microwave and Millimeter Wave Technologies A New X-Band Mobile Direction Finder",slug:"microwave-and-millimeter-wave-technologies-a-new-x-band-mobile-direction-finder",signatures:"Sergey Rаdionov, Igor Ivanchenko, Maksym Khruslov, Aleksey Korolev and Nina Popenko",authors:[null]},{id:"10346",title:"Characterization Techniques for Materials’ Properties Measurement",slug:"characterization-techniques-for-materials-properties-measurement",signatures:"Hussein Kassem, Valerie Vigneras and Guillaume Lunet",authors:[null]},{id:"10340",title:"Implementation of the Front-End-Module with a Power Amplifier for Wireless LAN",slug:"implementation-of-the-front-end-module-with-a-power-amplifier-for-wireless-lan",signatures:"Jong-In Ryu, Dongsu Kim and Jun-Chul Kim",authors:[null]},{id:"10350",title:"Millimeter-Wave Imaging Sensor",slug:"millimeter-wave-imaging-sensor",signatures:"Masaru Sato and Koji Mizuno",authors:[null]},{id:"10348",title:"Fractal Antenna Applications",slug:"fractal-antenna-applications",signatures:"Mircea V. Rusu and Roman Baican",authors:[null]},{id:"10345",title:"Analysis and Design of Radome in Millimeter Wave Band",slug:"analysis-and-design-of-radome-in-millimeter-wave-band",signatures:"Hongfu Meng and Wenbin Dou",authors:[null]},{id:"10349",title:"Design of Dielectric Lens Antennas by Multi-Objective Optimization",slug:"design-of-dielectric-lens-antennas-by-multi-objective-optimization",signatures:"Yoshihiko Kuwahara and Takashi Maruyama",authors:[null]},{id:"10358",title:"Modelling and Design of Photonic Bandgap Devices: a Microwave Accelerating Cavity for Cancer Hadrontherapy",slug:"modelling-and-design-of-photonic-bandgap-devices-a-microwave-accelerating-cavity-for-cancer-hadronth",signatures:"Roberto Marani and Anna Gina Perri",authors:[null]},{id:"10351",title:"Specific Millimeter-Wave Features of Fabry-Perot Resonator for Spectroscopic Measurements",slug:"specific-millimeter-wave-features-of-fabry-perot-resonator-for-spectroscopic-measurements",signatures:"Petr Piksa, Stanislav Zvanovec and Petr Cerny",authors:[null]}]}],publishedBooks:[{type:"book",id:"1565",title:"Bolometers",subtitle:null,isOpenForSubmission:!1,hash:"c193ef12df5ac7a70b88a3b56c786e45",slug:"bolometers",bookSignature:"A. G. Unil Perera",coverURL:"https://cdn.intechopen.com/books/images_new/1565.jpg",editedByType:"Edited by",editors:[{id:"92217",title:"Prof.",name:"Unil",surname:"Perera",slug:"unil-perera",fullName:"Unil Perera"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3623",title:"Advanced Microwave and Millimeter Wave Technologies",subtitle:"Semiconductor Devices Circuits and Systems",isOpenForSubmission:!1,hash:null,slug:"advanced-microwave-and-millimeter-wave-technologies-semiconductor-devices-circuits-and-systems",bookSignature:"Moumita Mukherjee",coverURL:"https://cdn.intechopen.com/books/images_new/3623.jpg",editedByType:"Edited by",editors:[{id:"24251",title:"Dr.",name:"Moumita",surname:"Mukherjee",slug:"moumita-mukherjee",fullName:"Moumita Mukherjee"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3707",title:"Microwave and Millimeter Wave Technologies",subtitle:"from Photonic Bandgap Devices to Antenna and Applications",isOpenForSubmission:!1,hash:null,slug:"microwave-and-millimeter-wave-technologies-from-photonic-bandgap-devices-to-antenna-and-applications",bookSignature:"Igor Minin",coverURL:"https://cdn.intechopen.com/books/images_new/3707.jpg",editedByType:"Edited by",editors:[{id:"123258",title:"Dr.",name:"Igor",surname:"Minin",slug:"igor-minin",fullName:"Igor Minin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3708",title:"Microwave and Millimeter Wave Technologies",subtitle:"Modern UWB antennas and equipment",isOpenForSubmission:!1,hash:null,slug:"microwave-and-millimeter-wave-technologies-modern-uwb-antennas-and-equipment",bookSignature:"Igor Minin",coverURL:"https://cdn.intechopen.com/books/images_new/3708.jpg",editedByType:"Edited by",editors:[{id:"123258",title:"Dr.",name:"Igor",surname:"Minin",slug:"igor-minin",fullName:"Igor Minin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4617",title:"Advanced Electromagnetic Waves",subtitle:null,isOpenForSubmission:!1,hash:"dffb45dc681f2d74f30ad9ab9c2c527f",slug:"advanced-electromagnetic-waves",bookSignature:"Saad Osman Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/4617.jpg",editedByType:"Edited by",editors:[{id:"100186",title:"Prof.",name:"Saad",surname:"Bashir",slug:"saad-bashir",fullName:"Saad Bashir"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"64348",title:"Updated Information on Some Cognitive Disorders",doi:"10.5772/intechopen.81826",slug:"updated-information-on-some-cognitive-disorders",body:'\nDisorders of cognition have been identified since the beginning of the humankind, and since then, different types of clinical presentation have been reported. The same happened with the clinical manifestations of dementia.
\nDementia is a neurodegenerative disorder characterized by a progressive decline in cognitive and functional abilities. This neurodegenerative process has multiple causes, clinical manifestations, and heterogeneity with respect to the impact of sex or gender on prevalence, risk factors, and outcomes [1, 2, 3].
\nIn 2015, it was estimated that there were 46.8 million people with dementia worldwide, of whom 58.0% were living in low- and middle-income countries, and that there were annually 9 million new global cases of dementia.
\nThe estimated prevalence of dementia varies from 4.7% in Central Europe to 8.7% in North Africa/Middle East, and 6.4% at North America. Currently, the number of patients with dementia is projected to increase to 131.5 million by 2050 [4].
\nApart from some neuropsychological test that we will describe at the end of this chapter, there are some radiological investigations that can help in increasing the certainty of dementia diagnosis. A positron emission tomography (PET) scan and a special form of MRI can more definitively confirm the diagnosis of various types of dementia and raise the accuracy of the diagnosis to 90%. A PET scan administered and reviewed by an expert delivers the most accurate and suggestive results while diagnosing dementia. The most accurate form of PET scanning for types of dementia is called stereotactic surface projection, which involves an advanced statistical analysis of the data.
\nWe did a bibliographic investigation, and then the PubMed, Embase, and Web of Science were searched. In this chapter, we comment about some types of dementia and cognitive impairment according to the available publications in the medical literature, and we also delivered some comments based on our clinical observation from working with affected patients in Mthatha (one of the rural areas of South Africa) over the past21 years.
\nThe first man who made allusions to dementia at the seventh-century BC was the Greek philosopher Pythagoras (Figure 1) followed by Solon, Aristotle, Plato, Cicero, Galen, Celsus, Roger Bacon, and others. That related cognitive dysfunction with the aging on the brain is not well described until 1906, when Alois Alzheimer (Figure 2) found at postmortem brains of affected younger people, with dementia symptoms the microscopic plaques and tangles now known as hallmarks of the disease.
\nPythagoras of Samos (c 570 BC–c 495 BC).
Alois Alzheimer 1864–1915 from Bavaria.
The concept of MCI is described in the nineteenth century when loss of recent memories was documented as the first sign of dementia [5]. Some degree of cognitive disturbance was thought to be part of normal aging, and then various names were used to define it such as (1) age-associated memory impairment, (2) age-associated cognitive decline, and (3) benign senescent forgetfulness [6, 7].
\nIn 1980, with the arrival of new neuropsychological test to measure subjective and objective cognition, an intermediate phase between normal aging and dementia became more widely accepted [8]. At that time, it was defined as the presence of subtle deficits in cognition with some impairment in executive function. Following an expert international conference, all previous definitions and the way of diagnosis and management of MCI were better performed [9, 10].
\nHistorically, the term MCI has been in the literature for almost four decades, with the initial use coming from investigators at the New York University who referred to stage 3 on the Global Deterioration Scale as being MCI [11].
\nIn 1999, some authors at the Mayo Clinic reported subjects in their community aging study presenting a memory problem beyond what was expected for age and who demonstrated a MCI (by neuropsychological test) yet did not meet criteria for dementia [12].
\nThe prevalence of MCI is estimated around 3–19% in the elderly people. However, in a community setting, 44% of people with MCI returned to normal after 1 year [13].
\nConversion rates to dementia vary according to the setting, with 11–33% conversion over 2 years [14].
\nIn 2015, other authors demonstrate that females with MCI have greater longitudinal rates of cognitive and functional progression than males [15].
\nGauthier et al. [9] also defined MCI as a syndrome of cognitive decline, which is greater than would be expected for an individual’s age and level of education but does not impede the individual’s ability to perform daily activities of normal life.
\nMost of our patients presenting MCI had behavioral changes, depression, anxiety, and apathy, and most of them were full aware on their condition and personal frustrations, and their daily skills and activities necessary for independent daily living within the home and their communities such as dressing, grooming, ambulating, feeding, bathing, continence, transferring, and toileting were not affected. However, some authors have report that MCI patients may have difficulties in performing instrumental activities such as cooking, shopping, cleaning, laundry, driving, self-medication, and making call telephonically, among others, comparing to age-matched normal cognitively people [16, 17].
\nThe Mayo Clinic criteria previously cited have been focused on a memory disorder and were delivered to clarify the earliest symptomatic stages of AD. However, soon later, it was well established that not all intermittent cognitive states were due to incipient AD and not all patients have just a memory impairment. To solve this dilemma, the Key Symposium was held in Stockholm, Sweden, in 2003, and in 2004, broad scope and other goal were delivered [18, 19].
\nIncluding a broad classification scheme beyond memory, the recognition of MCI could result from multiple causes and not just AD.
\nThe Key Symposium characterization has been very useful in our practice and allowed us to distinguish the amnestic form of MCI from the nonamnestic ones, among other benefits.
\nRecently, Su et al. demonstrated that CA1 atrophy and subiculum thinning is significantly greater in AD and MCI patients than their control group, but similar between MCI and AD, as have been reported in previous investigations. It is proved that CA1 and subiculum changes at the hippocampus occur early on these pathologies [20].
\nNumerous international studies have been completed involving several thousand subjects, and these studies tend to estimate the overall prevalence of MCI in the range of 12–18% in persons above the age of 60 years. Lifestyle modifications and other nonpharmacologic therapies have been investigated by Petersen who found that aerobic exercise may be effective at reducing the rate of progression from MCI to dementia. Criticism has been raised regarding the boundaries of the condition of MCI with respect to differentiating it from changes of cognitive aging and also differentiating it from dementia [21].
\nBiomarkers provide a path toward the early detection of people at high risk for cognitive disorder and thereby its early prevention and/or management.
MCI is well represented in our series PD, and in our opinion, Parkinson’s disease-cognitive rating scale seems to be more selective in detecting MCI and PDD than Montreal Cognitive Assessment.
\nPlasma α-synuclein level was not associated with the presence or type of cognitive impairment, but the
The biomarkers of cognitive disorder in patients with diabetes can be grouped according to the following three aspects:
Functional or metabolic changes by neuroimaging tools
Serum molecules or relevant complications
Genetic types
In diabetic patients with cognitive disorder such as specific factors related to associated depression, inflammation, poor glucose metabolism, insulin resistance, micro/macrovascular complications, neurotrophic molecules, adipokines, and Tau protein presented remarkable changes. In diabetic patients, some neuroimaging studies provide more information on functional, structural, and metabolic changes during the cognitive decline progression [23].
\nPublications from several authors suggest that greater degrees of atherosclerosis of the carotid artery are associated with the progression from MCI to dementia [24, 25].
\nIn another study, the authors demonstrated that alterations in the intima media thickness (IMT) of the common carotid artery and the number of plaque (confirmed by ultrasound) are associated with an increased risk of MCI and dementia. In MCI, the IMT was more frequently observed, whereas in patients with dementia, the most common finding was increased numbers of carotid plaques. These researchers suggest that their findings may aid in identifying elderly people at higher risk for the progression of MCI when morphological impairment of cerebrovascular structures has been identified. In other words, the presence of atherosclerotic changes and modifications in blood factors such as p-selectin glycoprotein ligand, platelet-leukocyte aggregates, and platelet-monocyte aggregation can be used to predict MCI and dementia [26].
\nSome authors introduced a novel methodology to get an accurate classification of patients with AD or MCI from cognitively unimpaired (CU) people for clinical diagnosis and adequate intervention, respectively. These researchers focused on differentiating AD or MCI from CU based on the multifeature kernel supervised within-class-similar discriminative dictionary learning algorithm confirmed that methodology had superior performance in face recognition. They also included structural MRI, fluorodeoxyglucose PET, and florbetapir-PET data from the Alzheimer’s Disease Neuroimaging Initiative database for classification of AD versus CU, MCI versus CU, as well as AD versus MCI, successfully [27].
\nTai Chi is a type of mind-body exercise that combines physical and cognitive-stimulating activity that provides good benefits on general cognition and instrumental activities of daily living in patients with MCI [28].
\nMueller et al. [29] have documented spoken language as a noninvasive, multidimensional, and informative biological sample for the early diagnosis of AD, primary progressive aphasia, and other cognitive disorders. They also confirmed that connected language analysis is one of the most promising state-of-the-art diagnostic tools for MCI. Their results provide evidence that features of connected language are associated with very early, subclinical memory loss in late-middle age. This study helped toward a better comprehension of early language dysfunction associated with a cognitive decline.
\nRecently, Shang et al. [30] investigated differences in plasma fatty acids, adiponectin, reptin, plasma markers of inflammation, serum amyloid A, plasma lipids, and low-density lipoprotein in patients with AD, MCI, vascular dementia, and ischemic stroke in comparison to normal controls. They found different levels in almost all patients, indicating that these diseases have diverse pathological mechanisms.
\nThe evaluation of inner retinal layers as a biomarker of MCI has brought more novel information about the possibility to predict cognitive decline, which can be used as prognostic information for patients who need to take financial and family decisions, advanced directives, afford care/residence decisions, etc. This reliable prognostic information and planification of the future will serve as significant societal benefit, taking into account the high societal cost of cognitive disorder care all over the world [31].
\nThe level of relationship between cognition and functional outcomes in the MCI population is affected mainly by cognitive domains and a little bit by age and educational level. Early identification of subtle functional disturbance in MCI and comprehension of its cognitive and noncognitive correlates are determinant in the diagnostic process because of its prediction for dementia progression [32].
\nA recent meta-analysis investigation showed that hearing impairment is associated with a higher risk of MCI and dementia in elderly people [33].
\nRecently, a group of Korean researches have confirmed that a dietary pattern based on seafood and vegetables in older Korean adults can reduce MCI remarkably [34].
\nRecent study made by Correa-Jaraba and colleagues confirmed that the event-related potential technique is useful for evaluating changes in brain electrical activity and increased amplitude of the P3a component is a novel neurocognitive marker for differentiating amnestic MCI [35].
\nOn the other hand, it seems to be that telerehabilitation by videoconference can improve cognitive function in patients with MCI, but this procedure needs more investigation to confirm its feasibility [36].
\nThree months ago, some investigators documented the association between the presence of hallucinations, delusions, anxiety, depression, and abnormal motor behavior, with the risk of developing incident dementia
Alzheimer’s disease is a progressive nonreversible neurodegenerative disorder, characterized by cognitive decline including learning capacity, emotional and behavioral alterations, motor skills impairment, including dysfunction of the autonomic nervous system and desynchronization of circadian rhythms. According to Picard et al. [41], early-onset Alzheimer’s disease (EOAD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of presenile neurodegenerative dementia (i.e., age at onset around 65 years old). Compared to the typical episodic memory dysfunction of late-onset AD, EOAD patients show a constellation of multidomain deficits at presentation, which can include not only memory, but also language, executive, visuospatial abnormalities, and behavioral disturbances like bvFTD cases [42].
\nVolumetric and cortical thickness studies have shown a prevalent involvement of posterior parietal regions in EOAD and of anterior fronto-insular-striatal areas in bvFTD [43, 44]. Some studies reported a greater white matter (WM) involvement in bvFTD compared to EOAD [45, 46, 47, 48, 49, 50]. Filippi et al. and Zhou et al. [51, 52] found a divergent pattern of altered functional connectivity in the default mode network (DMN) and salience network comparing EOAD and bvFTD patients.
\nSome specialists from Alzheimer’s Association consider that AD is the underlying cause of all types of dementia, and it is characterized by β-amyloid plaques, neurofibrillary tangles, and neurodegeneration in areas of the brain associated with cognition, such as the cortex and hippocampus. AD is also characterized by disturbances of the daily activities involving memory, speech and language, reasoning, planning, and other cognitive abilities [53].
\nThe Framingham Study, which followed up 2611 cognitively intact participants (1550 women and 1061 men) on many for 20 years, indicated that risk factor for AD in 65-year-old woman was almost twice that of men [1] because it seems to be that life expectancy is longer in ladies. Other epidemiologic investigations also confirmed that neurodegeneration develops more rapidly in females who are often diagnosed earlier than males [54, 55]. And they are often diagnosed earlier in the course of illness than men. In many cases, inflammation is another risk factor for AD that dysregulated neuroinflammatory reaction is another possible AD etiology, which is more pronounced in females [56, 57].
\nSome research suggests the important of sex differences in microglia development and in response to fluctuating gonadal steroids during the life and there are more microglia in female than males [58]. Females have been shown to have more microglia than males [1].
\nApart from the previous statements, some authors suggest that particular aspects of music perception such as pitch pattern analysis may open a channel on the processing of information streams in major dementia syndromes. Therefore, the potential selectivity of musical deficits for particular dementia syndromes and particular dimensions of processing warrants further systematic investigation [59].
\nBetween classical thiamine deficiency and Alzheimer’s disease (AD), many similarities exist and in both are associated reductions in brain glucose metabolism with cognitive deficits. Vitamin B1-dependent enzymes are critical components of glucose metabolism that are reduced in the brains of AD patients and by thiamine deficiency, and their decline could account for the reduction in glucose metabolism [59]. Nevertheless, many other conditions not related with AD can cause dementia as well, and it should be taken into account in the process of diagnosis and management. As the reader can see below, apart from AD, other types of dementia and their etiology are also listed.
\nIn the past decade, we applied the term “mild cognitive impairment (MCI) due to AD” to refer to the symptomatic predementia phase of AD; in other words, patients with cognitive decline whose primary underlying pathophysiologic was AD but no evidence of a remarkable impairment in social or occupational activities; currently, we separate those patients in two groups.
\nTypically, amnestic MCI is the type of prodromal stage of dementia due to AD, but other phenotypes can also mimic to this kind of dementia, such as posterior cortical atrophy (also known as the visual variant), logopenic aphasia, or a frontal lobe-dysexecutive presentation of AD. Therefore, as a general agreement, not all MCI is early AD. The Key Symposium characterization of MCI helps to differentiate between the amnestic form of MCI and the nonamnestic one. These clinical syndromes appeared to be aligned with causes in a differential fashion and may have variable outcomes [60]. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) criteria are useful in prediction of amnestic MCI progression to AD, including medial temporal lobe atrophy and hypometabolism in MRI and FDG-PET, respectively [10, 61, 62].
\nRecently, some researchers reported that plasma total tau and pTau181 levels were higher in AD dementia patients than those in cognitively unimpaired. Plasma pTau181 was more strongly associated with both Aβ and tau PET. Plasma pTau181 was a more sensitive and specific predictor of elevated brain Aβ than total tau and better than the combination of age and apolipoprotein E, and they concluded that plasma pTau181 may have utility as a biomarker of AD pathophysiology and as a noninvasive screener for elevated brain Aβ [63].
\nFew weeks ago, some authors have found that [18F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [18F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [18F]AV-1451 uptake and cortical thickness. Therefore, all these findings support a close relationship between tau and hypometabolism in Alzheimer’s disease but show that correlations between neuroimaging modalities vary across participants [64].
\nSome investigations have confirmed that people with MCI and a positive amyloid PET scan are more liable to progress rapidly and, again, ADNI data confirmed this. Nevertheless, it is well known that carriers of the apolipoprotein E4 (
The study done by Hansson and colleagues relieved more information with regard to these data and corroborates the suspicion that those individuals, particularly with amnestic MCI presenting low CSF levels of Aβ42 and elevated total tau and phosphorylated tau, are at the higher risk for progressing faster than those patients with the same clinical phenotype but normal biomarkers on the CSF [66, 67].
\nAll people presenting a mild cognitive impairment in our series did not present an early Alzheimer’s disease later.
\nThe criteria for MCI due to AD developed by the National Institute on Aging and the Alzheimer’s Association essentially adopted the Key Symposium criteria and explained more explicit some of the diagnostic features. These criteria also considered biomarkers for underlying AD’s pathophysiology trying to define the underlying cause and, hence, predict outcome.
\nNow, the pathological criteria for AD require the presence of Aβ deposition in plaques and tau deposition in neurofibrillary tangles. The absence of biomarkers of Aβ deposition strongly suggests that AD is not the cause of MCI.
\nThe definitive absence of evidence of either Aβ deposition strongly suggests that the MCI syndrome is not due to AD. This marker analyses the lower Aβ42 levels on CSF [68] and the evidence of Aβ deposition, using a variety of specific ligands in PET scan [69] and the increased accumulation of tau or phosphorylated tau in the CSF is another biomarker [68].
\nAD and atrophy in entorhinal cortex (ERC), the hippocampus, and its subfields Cornu Ammonis 1(CA1) and subiculum are simultaneous, and these abnormalities can predict conversion from MCI to clinical AD. It has been documented that in the early stages of AD, some changes at the stratum radiatum, lacunosum, and molecular involving ERC and CA1 can be observed [70].
\nLewy body dementia and other types of cognitive disorder are not included in this revision due to limitation of space.
\nParkinson’s disease (PD) is an idiopathic type of parkinsonism, which progresses gradually in spite of the medical or surgical treatment implemented and it is characterized by bradykinesia, tremor at rest, gait disturbance, postural problems, rigidity, dysarthria, dysfunction of the judgment, reasoning, memory, depression, anxiety, insomnia, and cognitive decline due to loss of midbrain dopaminergic neurons in the pars compacta of the substantia nigra and consequent loss of dopamine input to the caudate nucleus and putamen (striatum), and it is more prevalent in men, whereas rigidity, difficulties pertaining to daytime sleepiness, dribbling saliva, interest in sex, and problems having sex are more common among men with PD [71].
\nDementia affected almost 50% of our patients with PD within the first decade after diagnosis is made, but the intensity of their manifestations varied considerably among them. Prospective investigations reveal patient differences in the progression of cognitive deficits and in risk factors for developing PD dementia (PDD) [72].
\nAs new disease-modifying treatments in Parkinson’s are emerging, early intervention to slow or prevent Parkinson’s dementia is becoming a realistic prospect.
Earlier detection of cognitive involvement offers the hope of prognostic information.
Finding the earliest features of cognitive involvement may provide insights into underlying mechanisms of disease progression, ultimately leading to identification of novel therapeutic targets [73].
The concept of MCI is introduced in the 1980s, and it is characterized mild cognitive deficits that did not qualify to a diagnosis of dementia in patients with AD, and more recently, it was also introduced for patients with PD [5].
\nAs far as we remember, the concept of “mild cognitive impairment” as a transitional or predementia state in Parkinson’s disease was delivered before 2014, and we also believe that PD-MCI is a transitory stage between normal cognition and dementia.
\nA recent study showed a strong correlation between the extent of neurofibrillary tangles and alpha synuclein [74]. It seems to be that the insula lobe is one of the vulnerable regions by alpha-synuclein deposition.
\nThe treatment of cognitive symptoms has shown some good results with the introduction of cholinesterase inhibitors (ChEIs) that is more effective in PDD, compared to AD, because of their early, prominent CNS cholinergic disturbance [75].
\nRivastigmine has been approved by the United States and European Union for the treatment of PDD with promissory results, while levodopa and other dopaminergic medications are still effective for tremor and parkinsonian motor symptoms of PDD. For the treatment of psychotic manifestations, atypical antipsychotics (e.g., quetiapine, clozapine) have been used in PDD. There is current evidence-based medicine favoring clozapine in PDD [76].
\nNovel information about imagenological assessment of PDD is positron emission tomography (PET) scan using C-labeled radiotracer Pittsburgh compound B that has been widely applied for the in vivo assessment of amyloid-β (Aβ) deposition in patients with AD, with successful results [77, 78].
\nProgressive supranuclear palsy is included in the classification of Parkinsonism and is also a form of dementia that is characterized by vertical gaze palsy, falling backward, hypokinesia, rigidity, irritability, dysphagia, dysarthria, apathy, depression, and cognitive decline, which is sometimes misdiagnosed as PD. Based on clinical observations from our series of patients with Parkinsonism, neuropsychologically assessed at the early to moderate stages, cognitive decline was a common problem found and some of those patients developed dementia with reduction of quality of life and functional disability. However, an important number of patients presenting mild cognitive impairment (MCI) did not develop dementia up to date. Because we have not resting-state functional MRI (rs-fMRI) facilities in our setting, we could not document the expected structural and functional connectivity alterations of the brain. Recently, some author confirmed that the temporal connectivity alterations found in patients with PD and PD-MCI could be related to the presence of cognitive impairment in PD [79].
\nIdiopathic normal pressure hydrocephalus (iNPH) is an important geriatric disease, a treatable cognitive disorder, which can be reliably diagnosed with an organized approach, and its prevalence is expected to increase gradually. This type of hydrocephalus is characterized by late-onset, surgically treated progressive neurodegenerative disease caused by inadequate cerebrospinal fluid (CSF) dynamics and ventriculomegaly, while other types (including low-pressure hydrocephalus) are usually secondary to head injury, subarachnoid hemorrhage, infections, and other disorders that cause an accumulation of the cerebrospinal fluids (CSF) in the ventricular system of the brain mainly associated to its impaired drainage [80]. Approximately 700,000 persons may have iNPH in the United States. Neuroimaging with either CT or MRI is required for the diagnosis of iNPH [81].
\nThe iNPH, the most common form of hydrocephalus in adult’s population, affects the brain parenchymal on the cerebral hemisphere causing cognitive dysfunction, lack of balance, urinary urgency with or without incontinence, problem-solving disabilities, dysarthria, and apraxia of gait apart from spasticity, hyperreflexia, and other upper motor neuron signs.
\nGait apraxia is typically the first and worst disturbance in patients with iNPH. The overall prevalence of iNPH ranges from 0.02% to up to 5.9%, depending upon age and specific population studied [82, 83]. Another author reported a prevalence about 0.51–2.9% in the elderly population [84]. Some authors found that the male-to-female ratio for those with idiopathic NPH (iNPH) is 1.39:1 (
In patients presenting Huntington disease with an associated inability to walk or rapid progression of their symptoms, a diagnosis of iNPH should be considered, and they are going to improve the cognitive disorder, gait, and chorea after the lumbar puncture and surgical treatment [86].
\nMild apathy is the more common neuropsychiatric symptom in patients with iNPH, and the frontal lobe pathology is the main cause of increased correlation between neuropsychiatric symptoms and cognitive impairment [87].
\nMCI is quite common presentation in patients with iNPH, and their neuropathological findings are generally consistent with white matter damage, regardless of the underlying, yet unknown, pathophysiological mechanisms [88, 89, 90, 91, 92].
\nDiffusion tensor imaging (DTI) is a useful MRI technique that can reflect the structural integrity and interstitial space of the white matter by detecting the directionality of extracellular water diffusion [fractional anisotropy (FA)] and of free water diffusion [mean diffusivity (MD)] and has been applied to evaluate white matter damage in iNPH [93, 94, 95, 96]. Some authors have confirmed that after shunt surgery in patients presenting iNPH, the fractional anisotropy (FA) in the corona radiata decreases, and the regions involved were located between the enlarged lateral ventricles and Sylvian fissures. The plasticity of the brain for mechanical pressure from the CSF system is also confirmed by their findings [97]. An interesting exception found in iNPH is the increased FA within the corticospinal tract [98, 99, 100, 101, 102].
\nTreatment outcome can be predicted by quantitative image biomarker from diffusion MRI, which also serves to distinguish between reversible and irreversible changes in iNPH [103].
\nAlzheimer’s disease can be differentiated from iNPH by cerebral retention of Pittsburgh compound B (PIB:
In 2016, several studies on iNPH were published in the medical literature [105]. Below, interested readers can find a summary from the most relevant conclusions.
\nThere is no standardization of care or differentiation between various types of hydrocephalus among the confirmed cases of hydrocephalus in the Middle East.
\nThe most common complication seen in postshunting surgery is subdural hematoma, and it shows reduced and even worsening of gait in iNPH.
\nRemarkable improvements in gait and clinical outcome are seen in patients presenting iNPH after shunting surgical procedures.
\nAfter 6 months of shunt surgery in patients presenting iNPH, the best test for identifying clinical improvements is the European-iNPH scale.
\nSome authors have demonstrated that the vascular brain expansion (during cardiac cycle) is quickly compensated by CSF volume flush, toward the spinal compartment due to a decreased spinal canal compliance, a decreased vascular brain expansion, or an increase of subarachnoid space resistance to CSF flow.
\nBased on the knowledge that venous drainage helps to control intracranial pressure, some authors have highlighted the potential role of the right side of the heart and the jugular vein valves in the physiopathology of the intracranial pressure.
\nIn iNPH, the main goal of shunt therapy is to improve the patient’s mobility and a mean improvement of 0.4 mph has been confirmed.
\nDr. Hakim described the iNPH for the first time in 1964, but its physiopathology was not satisfactorily elucidated as yet. Although changes seen on the brain parenchymal after shunt surgery have not been documented, it seems to be that a number of patients with cerebral atrophy could be presenting a reversible subarachnoid augmentation.
\nAt the present moment, reliable biomarkers for selection of iNPH patients for shunt therapy and T-tau or Aβ-42 for predicting shunt responsiveness are not available and need to be identified. Nevertheless, some potential microRNA biomarkers in the CSF are useful to differentiate iNPH patients from other presenting overlapping symptoms of other disorders such as AD, PD, and progressive supranuclear palsy.
\nA possible genetic component involved in the pathogenesis of iNPH may be present.
\nIn iNPH patients, the endoscopy third ventriculostomy is also a choice of treatment although some authors have found that it is not effective in treatment of iNPH [106, 107].
\nVentriculoatrial shunt (VAS) is another choice of treatment of iNPH, and some authors recommend it as a first choice because it is more physiological, no cardiopulmonary complications have been reported, and less shunt malfunction in the follow-up is found.
\nThe CSF tap test shows good results for diagnosis of iNPH, but its accuracy is not certain, even for bedridden patients, indicated.
\nThe relationship between radiological markers and mortality rate in iNPH is unknown. However, in AD and VaD, the radiological findings are related with high mortality.
\nA possible comorbidity between FTD and iNPH is suspected because the prevalence of the C9ORF72 is greater than expected.
\nThe genetic and pathophysiological mechanism in AD and iNPH are completely independent.
\nSometimes, the best selection of iNPH patients for VPS can be very difficult, but the CSF tap test by removing 30–50 ml of CSF can be used as prognostic test for shunt surgery outcome, but its negative predictive value is not certain. The most common interval between the LP and the formal follow-up examination is between 2 and 4 hours, and nauseous vomiting and headache are less frequent in iNPH patients than the other ones. Shunt surgery is not contraindicated in patients under antithrombotic therapy, and neurotoxic proteins in CSF can be removed from the brain and also improve learning, retention, and delayed recall of verbal memory. The vast majority of patients improve some memory functions [108].
\nAfter shunt surgery, some patients do not get the proper regular follow-up by their attending neurosurgeons apart from the first checkout surgical wound and are seen again when the shunt mechanism has failure (i.e., overdrainage due to shunt setting that is too low); patients develop some complication or neurological manifestations (headache that worsens with sitting and standing and improves when lying down) and pain or discomfort from the shunt components, including abdominal pain that requires surgical approach or risk of shunt infection. Longitudinal care can be provided by neurologists if they are well trained. Some adjustable shunts can be affected by strong external magnetic fields [81].
\nApart from iNPH patients with depression, the associated presence of delirium, hallucinations, visual or auditory agnosia, impaired naming, anosognosia, failure to recognize close relatives, families, and friends suggest a comorbidity with other types of dementia or neurological disorder [109].
\nObviously, in patients presenting dilatation of the ventricular system with an associated cognitive decline only or even only urinary incontinence, the attending doctor should search for another neurological disorder before considering iNPH mainly in those patients without gait disturbances. In cases presenting delirium and ventriculomegaly, the underlying cause of the delirium should be found, treatment initiated, and the patient must recover and return to a stable baseline before looking for iNPH [81]. Currently, the iNPH is the only type of dementia that has an effective treatment for slowing its progression or for curative purposes.
\nFrontotemporal dementia (FTD) is a common neurodegenerative disease associated with progressive atrophy of the frontal and temporal lobes, leading to changes in personality, behavior, and/or speech and language disorder. FTD is less common than the before-mentioned dementias. Among these clinical presentations, Pick’s disease is the most common type of presentation due to damage on the frontal and temporal lobes characterized by behavior and personality (apathy) disorders, which usually precede memory loss and dysarthria.
\nSometimes, clinical manifestations such as behavioral and personality changes, psychomotor slowness, and decline in executive functions can be seen in both iNPH and behavioral FTD (BvFTD) at the same time and indistinctly [110], and other neuropsychiatric symptoms are frequently detected in both diseases [111, 112] including mania, aggression, disturbances of impulse control, obsessive-compulsive disorder, and psychosis, including paranoia and hallucinations [113, 114, 115]. It is well known that personality changes, impulsive behavior, apathy, decreased social interest, and executive dysfunctions, including impairment in solving problems and inhibitory control, are typical manifestations of BvFTD [116]. Almost one-half of patients with frontotemporal lobe degeneration (FTLD) have a familial component, and some authors have found mutations in microtubule-associated protein tau, progranulin, and expanded hexanucleotide repeat in a noncoding region of the chromosome 9 open reading frame 72 (C9ORF72) as a common cause of the problem [117]. The expansion of C9ORF72 as a major genetic cause of FTLD has been confirmed by others [118]. On the other hand, Majounie et al. [119] reported that the C9ORF72 repeat expansion is the highest in Finland and is present in about 48% of familial FTLD.
\nAmyotrophic lateral sclerosis (ALS) is the most common motor presentation associated with the
To distinguish BvFTD from iNPH can be a very difficult task considering that both have similar clinical manifestations. Extrapyramidal clinical manifestations of parkinsonism are predominant in patients with BvFTD [117]. Apart from disorder of gait, other remarkable symptoms of iNPH are balance disturbances and psychomotor slowing [123]. Deficits in executive functions are core cognitive changes in both iNPH and BvFTD [116, 123].
\nSome authors have confirmed in large studies that the prevalence on FTD is 15 to 22/100,000 individuals [124, 125].
A new of variant of FTD named phenocopy frontotemporal dementia (phFTD) has been described by Meijboom et al. recently [127]. It is an uncommon and poorly understood clinical syndrome characterized by similar clinical manifestations of BvFTD without abnormalities on MRI of the brain and without associated cognitive disorder. In contrast to phFTD, functional connectivity and white matter (WM) microstructural abnormalities have been observed in bvFTD. Some authors concluded that phFTD and bvFTD may belong to the same disease spectrum.
\nCanu et al. [128] reported some multiparametric MRI findings useful to differentiate early onset of AD (EOAD) from BvFTD based on the cortical thinning of the precuneus, posterior cingulate, superior and inferior parietal lobe, supramarginal, postcentral, and lingual gyri, and lateral occipital cortex bilaterally, and the left rostral and caudal middle frontal gyri seen in EOAD. Compared with the control group, the authors found a widespread pattern of cortical thinning involving all cerebral lobes, and compared to EOAD, BvFTD patients showed cortical thinning on the lateral orbitofrontal gyrus and temporal pole bilaterally, right entorhinal cortex, and right medial orbitofrontal gyrus. A severe cortical involvement is suggestive of EOAD, while a prominent white matter damage might be indicative of bvFTD.
\nWernicke encephalopathy and Korsakoff syndrome [Wernicke-Korsakoff syndrome (WKS)] and alcohol-related dementia (ARD) are preventable, life-threatening neuropsychiatric syndromes resulting from thiamine deficiency mainly in patients with chronic alcoholism, anorexia nervosa or patients who have undergone bariatric surgery for obesity, chronic hepatic disease, immunodeficiency syndromes, nutritional deficiencies of any cause, metastatic carcinomas, hyperthyroidism, prolonged parenteral nutrition, hyperemesis gravidarum, long-term dialysis and diuretic therapy, among other causes, and clinically, patients’ complaints about short-term memory, confusional states, and neuropsychiatry manifestations.
\nIn most of our patients, WKS is an acute nutritional disorder characterized by the clinical triad of ophthalmoplegia, cerebellar disorder, and altered mental state secondary to neuronal loss and hemorrhagic lesions in the periaqueductal gray matter of the midbrain, the anterior thalamus, and hypothalamus.
\nAltered mental state includes abulia, inattentiveness, and progressive memory disturbance with progressive deterioration of level of consciousness until comatose state if no treatment is received.
\nBefore ophthalmoplegia is established, the eye movement abnormalities begin with limitations of abduction or horizontal gaze, and gait ataxia progresses to inability to stand.
\nAll patients presenting thiamine deficiency improve their symptoms rapidly when thiamine is replaced in a timely fashion. Sometimes, patients do not improve completely, and nystagmus, broad-based gait, and cognitive dysfunction including a selective amnestic disorder (Korsakoff syndrome) remain present.
\nSome authors said that during the acute symptomatic stage of Wernicke encephalopathy, there is an impairment of the glucose and oxidative cellular energy metabolism, leading to an imbalance of the ionic gradients across the cell membrane causing cytotoxic edema (intracellular water shift and cell injury) and vasogenic edema because of breakdown of the blood-brain barrier permeability with intravascular fluids penetrating into cerebral parenchymal [102]. Currently, it is well known that the MRI findings of cytotoxic or vasogenic edema are a remarkable information to detect WE in clinical settings and the presence of bilateral symmetrical signal hyperintensities in the periventricular region of the third ventricle, periaqueductal area, and hypothalamus confirms clinical impressions of WE [129, 130].
\nDry beriberi happens when thiamine (vitamin B1) deficiency affects the central and peripheral nervous system, and wet beriberi happens when it damages the cardiovascular system. Ophthalmoplegia and nystagmus are present in 85% of patients with dry beriberi [131].
\nIn developing countries, Wernicke syndrome is more likely to occur in nutritionally deficient alcoholics than in comparably deficient nonalcoholics, and thiamine deficiency in a nonalcoholic is more likely to produce wet beriberi with polyneuropathy than Wernicke syndrome [132]. However, several of Korsakoff’s original patients had not been heavy drinkers [133].
\nNeuropathological report and MRI studies have confirmed that excessive and prolonged use of alcohol may lead to structural and functional damage that is permanent in nature [134].
\nChronic and excessive drinking of alcohol can affect mentation in a different way, the commonest affected mechanism are systems of neurotransmitter by inhibition of excitatory glutamate receptors and by inhibition of γ-aminobutyric acid receptors [135]. In conclusion, alcohol intoxication has some mechanism to produce nervous system damage, including glutamate excitotoxicity and oxidative stress, which is increased by thiamine deficiency, hyperhomocysteinemia, and folate deficiency. Homocysteine functions as an agonist at glutamate NMDA receptors, increasing NMDA receptor transmission and the potential for excitotoxicity [136, 137, 138].
\nBy neuropsychological investigations, Goldstein and Shelly [139] documented brain pathology in about 78% of patients with chronic alcoholism. However, there is debate about the relative contributions of the direct toxic effect of alcohol (ARD), and the impact of thiamine deficiency, to lasting damage [140]. The two main syndromes about alcohol-associated cognitive disorders are WKS and ARD. The last one has enjoyed little recognition as a discrete clinical entity because of lack of a distinct pathophysiological profile [141, 142].
\nCurrently, it is well known that low-to-moderate ethanol consumption can reduce the risk of coronary syndrome and ischemic stroke due to the inhibitory effect of alcohol on platelet aggregation and the reduction of inflammatory markers and also by changing the lipid profile [143], while attempts to define a safe dose threshold for ethanol have been inconsistent. Parson and Nixon [144] reviewed 19 published studies addressing this issue and concluded that 5 or 6 “standard drinks” per day over extended periods resulted in “cognitive inefficiencies”, that 7–9 drinks per day resulted in “mild cognitive deficits,” and that 10 or more drinks per day caused impaired cognition of a degree encountered in frank alcoholics.
\nThe neurotoxic effect of ethanol on memory and learning has been confirmed in animal studies [145, 146], and the abnormalities are found on the dentate granule cells, loss of hippocampal CA1 and CA3 pyramidal neurons, mossy fiber-CA3 synapses, pathological changes in neurons of cerebral cortex, hypothalamus, brainstem, loss of cholinergic neurons in the basal forebrain, and impaired pruning of redundant cortical synapses during early development [147, 148, 149, 150, 151, 152].
\nMuch of the debate surrounding ARD encompasses whether it is possible to have a dementia that is the direct result of ethanol neurotoxicity—a primary alcoholic dementia—or whether the clinical presentation of dementia represents another underlying pathology (that is, thiamine deficiency) or multiple factors (for example, neurotoxicity in combination with nutritional deficiencies). Attempts to clarify this have been hindered by confounding factors that often accompany the lifestyles of alcohol abusers, such as head injury, psychiatric and other substance abuse comorbidities, and a higher rate of vascular risk factors [153].
\nAccording to neuroimaging and neuropathological findings, the main damage on the brain (in ethanol abuser) is prominent white matter loss (most remarkable in the prefrontal cortex, corpus callosum, and cerebellum) and neuronal loss in the hypothalamus, superior frontal association cortex, and cerebellum [154]. Nevertheless, the most susceptible region is the frontal lobe with documented evidence of markedly decreased neuron density, volume shrinkage, and abnormal glucose metabolism and perfusion [155]. Cholinergic neurotransmission in the basal forebrain, which plays a key role in attention, learning, and memory, also appears to be damaged by prolonged ethanol intake [156, 157].
\nThiamine deficiency as a main cause for the development of ARD is another hypothesis, and ethanol abusers are at particularly high risk of thiamine deficiency due to poor dietary nutrition and also because of the direct effect of ethanol on thiamine metabolism [130].
\nApart from deficient in thiamine, nicotinic acid, other B vitamins, and folate, alcoholics frequently develop neurological disorders associated with malnutrition, including cerebellar degeneration, amblyopia, polyneuropathy, and disorders affecting cognition. In pellagra, nicotinic acid deficiency results in skin, gastrointestinal, and mental abnormalities, which can progress to memory impairment, delusions, hallucinations, dementia, or delirium; hypertonus and startle myoclonus may be present. Symptoms usually improve following treatment with nicotinic acid or nicotinamide [158].
\nSome authors documented that ARD and WKS are different pathological process with overlapping clinical symptoms and both can be associated with ataxia and polyneuropathies [159].
\nOne of the problems that we afford is the variety of available definitions for “standard drink” and its different meanings from country to country. While a standard drink in the United Kingdom contains 8 g of alcohol, a standard drink in Australia contains 10 g and in America and Japan contains 14 and 19.7 g, respectively [160], which affect the best comprehension of the information delivered in the medical literature.
\nAs it was mentioned before, in the review made by Parson and Nixon in 1989, they found that consumption of five to six drinks per day (which, by US standards, equates to 70–84 g) over extended periods results in “cognitive inefficiencies,” while consumption of 10 or more standard drinks a day manifests as moderate cognitive deficits equivalent to that found in individuals with diagnosed alcoholism [144], and studies conducted by Oslin and colleagues [161] suggested that consuming 35 standard drinks a week for men and 28 for women for 5-year history constitutes a sufficient level of neurotoxic burden to risk the development of ARD. However, other studies found that light to moderate ethanol intake
Damage of the brain seen on MRI is the biggest in female’s alcoholic patients compared with the male’s ones. Therefore, it seems to be that females are more susceptible than males to adverse ethanol’s effect, but their recovery after abstinence is better [171].
\nBecause of the introduction of thiamine supplementation programs in some countries, as well as general dietary habits, there is no direct correlation between the prevalence of WE and per capita consumption of standard drinks, but all patients under suspicion of having WE should be treated immediately with parenteral thiamine [130]. Thiamine given orally does not work because it reaches poor concentration in plasma; therefore, a dosage of 200 mg IV three times a day (1 g may be required in the first 24 hours) for 5–7 days followed by oral thiamine in doses of 100 mg eight hourly for 1–2 weeks is strongly recommended. At this point, it is very important to highlight that other electrolyte deficiencies such as magnesium and niacin should also be corrected. Apart from parenteral thiamine, to eat food with a high content of vitamins such as peas, lentils, brown rice, pork, organ meats, milk, eggs, nuts, fruits, and vegetables is suggested. Alcohol interferes with thiamine uptake [172]. This treatment should be continued until no further improvement in signs and symptoms is evident [173].
\nSome patients with ARD and WKS have shown cognitive improvement following treatment with memantine, although these findings require replication [174, 175].
\nAs we also mentioned before, ARD and WKS have some similarities. However, some neuropsychological studies have largely attempted to differentiate these syndromes by limiting individuals with more global cognitive impairment from WKS investigations and by excluding individuals with past symptoms of WKS from ARD studies, but the validity of this distinction is now being brought into question [140].
\nEthanol concentration in blood raises blood levels of high-density lipoprotein cholesterol (HDL-C) in a dose-dependent fashion, and some studies suggest that this effect accounts for at least half of the protection against CAD [176]. Ethanol also increases insulin sensitivity [177], prevents platelet aggregation [178], increases fibrinolysis [179], opposes thrombin activity [180], and reduces inflammatory markers such as plasma C-reactive protein and fibrinogen levels [181].
\nIn a prospective 12-week study done by Cheon et al. on patients with probable ARD, they found that memantine (a low-affinity NMDA receptor antagonist) improved global cognition, quality of life, and behavioral symptoms on their patients [174]. Another investigation reported that rivastigmine at the dose of 3–12 mg per day for 2 months improved clinical manifestations of ARD [185].
\nBecause not all ARD patients recover from abstinence, around 20% of them need long-term admissions and the amount of ARD patients will increase gradually due to the growing proportion of aging population and rise in per capita ethanol consumption [174, 183].
\nResults of neuroimaging studies have corroborated postmortem neuropathological studies and have expanded the understanding of the neuropsychological deficits resulting from thiamine deficiency, alcohol neurotoxicity, and their combined effect [188].
\nFirst of all, it is very important to highlight the importance of clinical assessment on any type of dementia followed by imagenology and other investigations. The best assessment can be done by the well-skilled health-care professional knowing the clinical features of all dementia, duration, frequency, and rate of progression. This professional must guarantee an adequate comfortableness of the patients, while the process of diagnosis is finished. Therefore, the patient’s fears regarding type of dementia and condition should be well managed including a full review of the patient’s health care, family history and treatment history, proper evaluation for depression, toxic substance abuse and nutrition, and other conditions that can cause memory dysfunction such as infections, chronic anemia, vitamin deficiency, diabetes mellitus type 2, chronic kidney or liver disease, thyroid gland disease, cardiopulmonary disorders, and other risk factors for dementia including hearing loss. Currently, there is no single test that confirms Alzheimer’s disease, although to achieve 90% accuracy is certain. Nevertheless, to identify the true underlying cause of the problem can be very difficult.
\nFindings from physical examination are crucial, and some laboratory tests such as CFS levels of total tau protein results are of relevant importance for identifying type of dementia and way of management. One of the most recent investigations has documented the results from evaluation of cerebrospinal fluid phosphorylated tau231 as a biomarker in the differential diagnosis of Alzheimer’s disease and vascular dementia by assessing whether the use of sensitive and specific biomarkers such as phosphorylated tau proteins could contribute to an earlier and more accurate diagnosis of AD and VD, as well as to their differentiation, and the authors found that FS (p-tau231 and MMSE) has a strong potential to provide an early distinction between AD and VD [189, 190].
\nObviously, according to the statement mentioned before, not every health professional is familiar with the complexities of dementia diagnosis. Therefore, to select the medical doctor with the necessary skill and experience to diagnose all different types of dementia is mandatory.
\nBelow, we describe the most commonly used tests to diagnose dementia.
\nThe MMSE is the most widely used cognitive screening test worldwide, and it is a very brief investigation of the patient’s cognitive status used in diagnosing dementia types and serves to evaluate appearance and behavior, attitude, perception, orientation, judgment, cognition, abstraction, and insight. It can be administered quickly and repetitively. Patient is requested to identify the time, date, and place (including street, city, and state) where the test is taking place, be able to count backward, identify objects previously known by them, be able to repeat common phrases, perform basic skills involving math, language, and comprehension, and demonstrate basic motor skills. This examination provides information to distinguish organic from “functional” illnesses and also provides objective data regarding the patient’s improving or deteriorating sensorium. It helps substantiate clinical decisions on competence, potential for danger, and hospitalization [191].
\nThe Mini-Cog is a brief, cognitive screening test that is frequently used to evaluate cognition in older adults in various settings; the mini-cog takes only a few minutes to administer and is used as an initial screening for different types of cognitive disorders. The patient is required to identify three objects in the office, then draw the face of a clock in its entirety from memory, and finally, recall the three items identified earlier.
\nThere are currently few studies assessing the diagnostic test accuracy of the Mini-Cog in community settings. The limited number of studies and the methodological limitations that are present in the study done by Fage et al.
Montreal Cognitive Assessment (MoCA) is a cognitive screening instrument that was designed to address some of the limitations of the MMSE [196].
\nBased on the MoCA scores, the patients were further categorized as normal cognition (PD-NC) if their MoCA scores were 26–30 or mild cognitive impairment (PD-MCI) if their scores were 18–25 according to a Malaysian study [197].
\nSome authors discovered that the Parkinson’s disease-cognitive rating scale (PDCRS) was better than MoCA in detecting MCI, while other test was more specific for executive dysfunction.
\nThey failed to demonstrate the association between plasma α-synuclein levels and cognitive impairment in their PD patients. However, genotype
We would like to thank Dr. NE Cishe, Director of the Research Office Walter Sisulu University; Penelope Dawson, Department of Research, Walter Sisulu University in South Africa; and Lorna Maria, Thabo Humberto Jorge, and Fatima Susana Adolfina for their unconditional support.
\nThe authors declare that this chapter was written in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We believe financial barriers should not prevent researchers from publishing their findings. With the need to make scientific research more publicly available and support the benefits of Open Access, more and more institutions and funders are dedicating resources to assist faculty members and researchers cover Open Access Publishing Fees (OAPFs). In addition, IntechOpen provides several further options presented below, all of which are available to researchers, and could secure the financing of your Open Access publication.
",metaTitle:"Waiver Policy",metaDescription:"We feel that financial barriers should never prevent researchers from publishing their research. With the need to make scientific research more publically available and support the benefits of Open Access, more institutions and funders have dedicated funds to assist their faculty members and researchers cover the APCs associated with publishing in Open Access. Below we have outlined several options available to secure financing for your Open Access publication.",metaKeywords:null,canonicalURL:"/page/waiver-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"At IntechOpen, the majority of OAPFs are paid by an Author’s institution or funding agency - Institutions (73%) vs. Authors (23%).
\\n\\nThe first step in obtaining funds for your Open Access publication begins with your institution or library. IntechOpen’s publishing standards align with most institutional funding programs. Our advice is to petition your institution for help in financing your Open Access publication.
\\n\\nHowever, as Open Access becomes a more commonly used publishing option for the dissemination of scientific and scholarly content, in addition to institutions, there are a growing number of funders who allow the use of grants for covering OA publication costs, or have established separate funds for the same purpose.
\\n\\nPlease consult our Open Access Funding page to explore some of these funding opportunities and learn more about how you could finance your IntechOpen publication. Keep in mind that this list is not definitive, and while we are constantly updating and informing our Authors of new funding opportunities, we recommend that you always check with your institution first.
\\n\\nFor Authors who are unable to obtain funding from their institution or research funding bodies and still need help in covering publication costs, IntechOpen offers the possibility of applying for a Waiver.
\\n\\nOur mission is to support Authors in publishing their research and making an impact within the scientific community. Currently, 14% of Authors receive full waivers and 6% receive partial waivers.
\\n\\nWhile providing support and advice to all our international Authors, waiver priority will be given to those Authors who reside in countries that are classified by the World Bank as low-income economies. In this way, we can help ensure that the scientific work being carried out can make an impact within the worldwide scientific community, no matter where an Author might live.
\\n\\nThe application process is open after your submitted manuscript has been accepted for publication. To apply, please fill out a Waiver Request Form and send it to your Author Service Manager. If you have an official letter from your university or institution showing that funds for your OA publication are unavailable, please attach that as well. The Waiver Request will normally be addressed within one week from the application date. All chapters that receive waivers or partial waivers will be designated as such online.
\\n\\nDownload Waiver Request Form
\\n\\nFeel free to contact us at funders@intechopen.com if you have any questions about Funding options or our Waiver program. If you have already begun the process and require further assistance, please contact your Author Service Manager, who is there to assist you!
\\n\\nNote: All data represented above was collected by IntechOpen from 2013 to 2017.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'At IntechOpen, the majority of OAPFs are paid by an Author’s institution or funding agency - Institutions (73%) vs. Authors (23%).
\n\nThe first step in obtaining funds for your Open Access publication begins with your institution or library. IntechOpen’s publishing standards align with most institutional funding programs. Our advice is to petition your institution for help in financing your Open Access publication.
\n\nHowever, as Open Access becomes a more commonly used publishing option for the dissemination of scientific and scholarly content, in addition to institutions, there are a growing number of funders who allow the use of grants for covering OA publication costs, or have established separate funds for the same purpose.
\n\nPlease consult our Open Access Funding page to explore some of these funding opportunities and learn more about how you could finance your IntechOpen publication. Keep in mind that this list is not definitive, and while we are constantly updating and informing our Authors of new funding opportunities, we recommend that you always check with your institution first.
\n\nFor Authors who are unable to obtain funding from their institution or research funding bodies and still need help in covering publication costs, IntechOpen offers the possibility of applying for a Waiver.
\n\nOur mission is to support Authors in publishing their research and making an impact within the scientific community. Currently, 14% of Authors receive full waivers and 6% receive partial waivers.
\n\nWhile providing support and advice to all our international Authors, waiver priority will be given to those Authors who reside in countries that are classified by the World Bank as low-income economies. In this way, we can help ensure that the scientific work being carried out can make an impact within the worldwide scientific community, no matter where an Author might live.
\n\nThe application process is open after your submitted manuscript has been accepted for publication. To apply, please fill out a Waiver Request Form and send it to your Author Service Manager. If you have an official letter from your university or institution showing that funds for your OA publication are unavailable, please attach that as well. The Waiver Request will normally be addressed within one week from the application date. All chapters that receive waivers or partial waivers will be designated as such online.
\n\nDownload Waiver Request Form
\n\nFeel free to contact us at funders@intechopen.com if you have any questions about Funding options or our Waiver program. If you have already begun the process and require further assistance, please contact your Author Service Manager, who is there to assist you!
\n\nNote: All data represented above was collected by IntechOpen from 2013 to 2017.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6669},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2457},{group:"region",caption:"Asia",value:4,count:12710},{group:"region",caption:"Australia and Oceania",value:5,count:1016},{group:"region",caption:"Europe",value:6,count:17716}],offset:12,limit:12,total:134177},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{sort:"dateEndThirdStepPublish",topicId:"114"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:0},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4428},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"219",title:"Pharmacology",slug:"pharmacology-toxicology-and-pharmaceutical-science-pharmacology",parent:{id:"19",title:"Pharmacology, Toxicology and Pharmaceutical Science",slug:"pharmacology-toxicology-and-pharmaceutical-science"},numberOfBooks:52,numberOfSeries:0,numberOfAuthorsAndEditors:1306,numberOfWosCitations:1376,numberOfCrossrefCitations:859,numberOfDimensionsCitations:2104,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"219",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editedByType:"Edited by",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9829",title:"Biosimilars",subtitle:null,isOpenForSubmission:!1,hash:"c72171c1d1cf6df5aad989cb07cc8e4e",slug:"biosimilars",bookSignature:"Valderilio Feijó Azevedo and Robert Moots",coverURL:"https://cdn.intechopen.com/books/images_new/9829.jpg",editedByType:"Edited by",editors:[{id:"69875",title:"Dr.",name:"Valderilio",middleName:"Feijó",surname:"Feijó Azevedo",slug:"valderilio-feijo-azevedo",fullName:"Valderilio Feijó Azevedo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10881",title:"Drug Repurposing",subtitle:"Molecular Aspects and Therapeutic Applications",isOpenForSubmission:!1,hash:"eca3f2d5ca97b457d38a2442b36d3ac7",slug:"drug-repurposing-molecular-aspects-and-therapeutic-applications",bookSignature:"Shailendra K. Saxena",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg",editedByType:"Edited by",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10234",title:"High-Throughput Screening for Drug Discovery",subtitle:null,isOpenForSubmission:!1,hash:"37e6f5b6dd0567efb63dca4b2c73495f",slug:"high-throughput-screening-for-drug-discovery",bookSignature:"Shailendra K. Saxena",coverURL:"https://cdn.intechopen.com/books/images_new/10234.jpg",editedByType:"Edited by",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11038",title:"Vaccine Development",subtitle:null,isOpenForSubmission:!1,hash:"2604d260662a3a3cc91971ea07beca61",slug:"vaccine-development",bookSignature:"Yulia Desheva",coverURL:"https://cdn.intechopen.com/books/images_new/11038.jpg",editedByType:"Edited by",editors:[{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10357",title:"Drug Metabolism",subtitle:null,isOpenForSubmission:!1,hash:"3bd3ae5041cab45020555b49152b1ddc",slug:"drug-metabolism",bookSignature:"Katherine Dunnington",coverURL:"https://cdn.intechopen.com/books/images_new/10357.jpg",editedByType:"Edited by",editors:[{id:"232694",title:"Dr.",name:"Katherine",middleName:null,surname:"Dunnington",slug:"katherine-dunnington",fullName:"Katherine Dunnington"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10735",title:"Metformin",subtitle:"Pharmacology and Drug Interactions",isOpenForSubmission:!1,hash:"fee7e27a0fa000d000c459ff6e4b749e",slug:"metformin-pharmacology-and-drug-interactions",bookSignature:"Juber Akhtar, Usama Ahmad, Badruddeen and Mohammad Irfan Khan",coverURL:"https://cdn.intechopen.com/books/images_new/10735.jpg",editedByType:"Edited by",editors:[{id:"345595",title:"Prof.",name:"Juber",middleName:null,surname:"Akhtar",slug:"juber-akhtar",fullName:"Juber Akhtar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10578",title:"Pharmacogenetics",subtitle:null,isOpenForSubmission:!1,hash:"ca2bc2ff6e15a7b735d662d9664086b1",slug:"pharmacogenetics",bookSignature:"Islam A. Khalil",coverURL:"https://cdn.intechopen.com/books/images_new/10578.jpg",editedByType:"Edited by",editors:[{id:"226598",title:"Dr.",name:"Islam",middleName:null,surname:"A. Khalil",slug:"islam-a.-khalil",fullName:"Islam A. Khalil"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10716",title:"Corticosteroids",subtitle:"A Paradigmatic Drug Class",isOpenForSubmission:!1,hash:"d600ff66a3b0544bcbb713ea46287590",slug:"corticosteroids-a-paradigmatic-drug-class",bookSignature:"Celso Pereira",coverURL:"https://cdn.intechopen.com/books/images_new/10716.jpg",editedByType:"Edited by",editors:[{id:"66336",title:"Prof.",name:"Celso",middleName:null,surname:"Pereira",slug:"celso-pereira",fullName:"Celso Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10236",title:"Plasmodium Species and Drug Resistance",subtitle:null,isOpenForSubmission:!1,hash:"964a389525d1147af3e527c056ac1a73",slug:"plasmodium-species-and-drug-resistance",bookSignature:"Rajeev K. Tyagi",coverURL:"https://cdn.intechopen.com/books/images_new/10236.jpg",editedByType:"Edited by",editors:[{id:"269120",title:"Dr.",name:"Rajeev",middleName:"K.",surname:"Tyagi",slug:"rajeev-tyagi",fullName:"Rajeev Tyagi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9833",title:"New Insights into the Future of Pharmacoepidemiology and Drug Safety",subtitle:null,isOpenForSubmission:!1,hash:"33c717cdacfd3327b4c5d516f96010e9",slug:"new-insights-into-the-future-of-pharmacoepidemiology-and-drug-safety",bookSignature:"Maria Teresa Herdeiro, Fátima Roque, Adolfo Figueiras and Tânia Magalhães Silva",coverURL:"https://cdn.intechopen.com/books/images_new/9833.jpg",editedByType:"Edited by",editors:[{id:"227508",title:"Prof.",name:"Maria Teresa",middleName:null,surname:"Herdeiro",slug:"maria-teresa-herdeiro",fullName:"Maria Teresa Herdeiro"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10232",title:"Theranostics",subtitle:"An Old Concept in New Clothing",isOpenForSubmission:!1,hash:"a283d1440c4b263c007d3f893f34c4f7",slug:"theranostics-an-old-concept-in-new-clothing",bookSignature:"Elisabeth Eppard",coverURL:"https://cdn.intechopen.com/books/images_new/10232.jpg",editedByType:"Edited by",editors:[{id:"245845",title:"Dr.",name:"Elisabeth",middleName:null,surname:"Eppard",slug:"elisabeth-eppard",fullName:"Elisabeth Eppard"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:52,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"40253",doi:"10.5772/50486",title:"Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development",slug:"lipid-nanoparticulate-drug-delivery-systems-a-revolution-in-dosage-form-design-and-development",totalDownloads:11245,totalCrossrefCites:21,totalDimensionsCites:103,abstract:null,book:{id:"2509",slug:"recent-advances-in-novel-drug-carrier-systems",title:"Recent Advances in Novel Drug Carrier Systems",fullTitle:"Recent Advances in Novel Drug Carrier Systems"},signatures:"Anthony A. Attama, Mumuni A. Momoh and Philip F. Builders",authors:[{id:"142947",title:"Prof.",name:"Anthony",middleName:null,surname:"Attama",slug:"anthony-attama",fullName:"Anthony Attama"}]},{id:"67939",doi:"10.5772/intechopen.85991",title:"Molecular Docking in Modern Drug Discovery: Principles and Recent Applications",slug:"molecular-docking-in-modern-drug-discovery-principles-and-recent-applications",totalDownloads:3853,totalCrossrefCites:25,totalDimensionsCites:59,abstract:"The process of hunt of a lead molecule is a long and a tedious process and one is often demoralized by the endless possibilities one has to search through. Fortunately, computational tools have come to the rescue and have undoubtedly played a pivotal role in rationalizing the path to drug discovery. Of all techniques, molecular docking has played a crucial role in computer aided drug design and has swiftly gained ranks to secure a valuable position in the modern scenario of structure-based drug design. In this chapter, the principle, sampling algorithms, scoring functions and diverse available software’s for molecular docking have been summarized. We demonstrate the interplay of docking, classical techniques of structure-based design and X-ray crystallography in the process of drug discovery. In addition, we dwell upon some of the limitations faced in docking studies. Finally, several success stories of molecular docking approaches in drug discovery have been highlighted, concluding with remarks on molecular docking for the future.",book:{id:"7867",slug:"drug-discovery-and-development-new-advances",title:"Drug Discovery and Development",fullTitle:"Drug Discovery and Development - New Advances"},signatures:"Aaftaab Sethi, Khusbhoo Joshi, K. Sasikala and Mallika Alvala",authors:[{id:"252956",title:"Dr.",name:"Mallika",middleName:null,surname:"Alvala",slug:"mallika-alvala",fullName:"Mallika Alvala"},{id:"287101",title:"Mr.",name:"Aaftaab",middleName:null,surname:"Sethi",slug:"aaftaab-sethi",fullName:"Aaftaab Sethi"},{id:"295049",title:"Ms.",name:"Khusbhoo",middleName:null,surname:"Joshi",slug:"khusbhoo-joshi",fullName:"Khusbhoo Joshi"},{id:"295050",title:"Ms.",name:"Sasikala",middleName:null,surname:"K",slug:"sasikala-k",fullName:"Sasikala K"}]},{id:"29240",doi:"10.5772/31087",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:27075,totalCrossrefCites:27,totalDimensionsCites:57,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"40262",doi:"10.5772/51384",title:"Nanotechnology in Drug Delivery",slug:"nanotechnology-in-drug-delivery",totalDownloads:15379,totalCrossrefCites:11,totalDimensionsCites:53,abstract:null,book:{id:"2509",slug:"recent-advances-in-novel-drug-carrier-systems",title:"Recent Advances in Novel Drug Carrier Systems",fullTitle:"Recent Advances in Novel Drug Carrier Systems"},signatures:"Martins Ochubiojo Emeje, Ifeoma Chinwude Obidike, Ekaete Ibanga Akpabio and Sabinus Ifianyi Ofoefule",authors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}]},{id:"40281",doi:"10.5772/52115",title:"Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery",slug:"magnetic-nanoparticles-synthesis-surface-modifications-and-application-in-drug-delivery",totalDownloads:12616,totalCrossrefCites:19,totalDimensionsCites:43,abstract:null,book:{id:"2509",slug:"recent-advances-in-novel-drug-carrier-systems",title:"Recent Advances in Novel Drug Carrier Systems",fullTitle:"Recent Advances in Novel Drug Carrier Systems"},signatures:"Seyda Bucak, Banu Yavuztürk and Ali Demir Sezer",authors:[{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"},{id:"129638",title:"Prof.",name:"Seyda",middleName:null,surname:"Bucak",slug:"seyda-bucak",fullName:"Seyda Bucak"}]}],mostDownloadedChaptersLast30Days:[{id:"49459",title:"Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration",slug:"pharmacokinetics-of-drugs-following-iv-bolus-iv-infusion-and-oral-administration",totalDownloads:15401,totalCrossrefCites:15,totalDimensionsCites:22,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"Tarek A. Ahmed",authors:[{id:"175649",title:"Dr.",name:"Tarek A",middleName:null,surname:"Ahmed",slug:"tarek-a-ahmed",fullName:"Tarek A Ahmed"}]},{id:"29240",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:27075,totalCrossrefCites:27,totalDimensionsCites:57,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:4035,totalCrossrefCites:14,totalDimensionsCites:29,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]},{id:"65128",title:"Natural Products in Drug Discovery",slug:"natural-products-in-drug-discovery",totalDownloads:6591,totalCrossrefCites:17,totalDimensionsCites:42,abstract:"Drug discovery using natural products is a challenging task for designing new leads. It describe the bioactive compounds derived from natural resources, its phytochemical analysis, characterization and pharmacological investigation. It focuses on the success of these resources in the process of finding and discovering new and effective drug compounds that can be useful for human resources. From many years, natural products have been acting as a source of therapeutic agents and have shown beneficial uses. Only natural product drug discovery plays an important role to develop the scientific evidence of these natural resources. Research in drug discovery needs to develop robust and viable lead molecules, which step forward from a screening hit to a drug candidate through structural elucidation and structure identification through GC–MS, NMR, IR, HPLC, and HPTLC. The development of new technologies has revolutionized the screening of natural products in discovering new drugs. Utilizing these technologies gives us an opportunity to perform research in screening new molecules using a software and database to establish natural products as a major source for drug discovery. It finally leads to lead structure discovery. Powerful new technologies are revolutionizing natural herbal drug discovery.",book:{id:"8290",slug:"pharmacognosy-medicinal-plants",title:"Pharmacognosy",fullTitle:"Pharmacognosy - Medicinal Plants"},signatures:"Akshada Amit Koparde, Rajendra Chandrashekar Doijad and Chandrakant Shripal Magdum",authors:[{id:"268668",title:"Dr.",name:"Akshada",middleName:"Amit",surname:"Koparde",slug:"akshada-koparde",fullName:"Akshada Koparde"}]},{id:"48805",title:"Biopharmaceutics and Pharmacokinetics",slug:"biopharmaceutics-and-pharmacokinetics",totalDownloads:26121,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"S. Lakshmana Prabu, T.N.K. Suriyaprakash, K. Ruckmani and R.\nThirumurugan",authors:[{id:"91590",title:"Dr.",name:"Sakthivel",middleName:null,surname:"Lakshmana Prabu",slug:"sakthivel-lakshmana-prabu",fullName:"Sakthivel Lakshmana Prabu"},{id:"128690",title:"Dr.",name:"Suriyaprakash",middleName:null,surname:"Tnk",slug:"suriyaprakash-tnk",fullName:"Suriyaprakash Tnk"}]}],onlineFirstChaptersFilter:{topicId:"219",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81238",title:"Artificial Intelligence in Healthcare: An Overview",slug:"artificial-intelligence-in-healthcare-an-overview",totalDownloads:31,totalDimensionsCites:0,doi:"10.5772/intechopen.102768",abstract:"The healthcare industry is advancing ahead swiftly. For many healthcare organizations, being able to forecast which treatment techniques are likely to be successful with patients based on their makeup and treatment framework is a big step forward. Artificial intelligence has the potential to help healthcare providers in a variety of ways, including patient care and administrative tasks. The technology aims to mimic human cognitive functions, as it offers numerous advantages over traditional analytics and other clinical decision-making tools. Data becomes more precise and accurate, allowing the healthcare industry to have more insights into the theranostic processes and patient outcomes. This chapter is an overview of the use of artificial intelligence in radiology, cardiology, ophthalmology, and drug discovery process.",book:{id:"10882",title:"Smart Drug Delivery",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg"},signatures:"Syed Shahwar Anwar, Usama Ahmad, Mohd Muazzam Khan, Md. Faheem Haider and Juber Akhtar"},{id:"79411",title:"Phospholipid Based Nano Drug Delivery Systems of Phytoconstituents",slug:"phospholipid-based-nano-drug-delivery-systems-of-phytoconstituents",totalDownloads:121,totalDimensionsCites:0,doi:"10.5772/intechopen.101040",abstract:"The development of phytochemistry and phyto-pharmacology has enabled elucidation of composition and biological activities of several medicinal plant constituents. However phytoconstituents are poorly absorbed due to their low aqueous solubility, large molecular size and poor membrane permeability when taken orally. Nanotechnology based drug delivery systems can be used to improve the dissolution rate, permeability and stability of these phytoconstituents. The current chapter aims to present the extraction of phytoconstituents, their identifications, and development/utilization of phospholipid based nano drug delivery systems (PBNDDS). The content of the chapter also provides characteristic features, in-vitro, in-vivo evaluations and stability performance of PBNDDS. The results from the UHPLC and GC-MS showed different phytoconstituents in the extracted samples with quantitative value. Dynamic light scattering (DLS) data showed PBNDDS of different phytoconstituents in the range of 50–250 nm with PDI value of 0.02–0.5, which was also confirmed by the electron microscopic data. Phytoconstituents loading or entrapment for PBNDDS was in the range of 60–95%. PBNDDS exhibited better in-vitro and in-vivo performance with improved Physico-chemical stability.",book:{id:"10882",title:"Smart Drug Delivery",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg"},signatures:"Mohammad Hossain Shariare and Mohsin Kazi"},{id:"79292",title:"Aliphatic Polyester Nanoparticles for Drug Delivery Systems",slug:"aliphatic-polyester-nanoparticles-for-drug-delivery-systems",totalDownloads:109,totalDimensionsCites:0,doi:"10.5772/intechopen.100977",abstract:"Drug delivery systems using aliphatic polyester nanoparticles are usually prepared via an emulsion process. These nanoparticles can control drug release and improve pharmacokinetics. Aliphatic polyesters are linear polymers containing ester linkages, showing sensitivity to hydrolytic degradation. The byproducts then promote autocatalytic degradation. These byproducts could enter the Krebs cycle and be eliminated from the body, resulting in the high biocompatibility of these nanoparticles. The properties of these polyesters are linked to the drug release rate due to biodegradation, i.e., polymer crystallinity, glass transition temperature, polymer hydrophobicity, and molecular weight (MW), all of which relatively influence hydrolysis. Mathematical equations have been used to study the factors and mechanisms that affect drug dissolution compared to experimental release data. The equations used as models for predicting the kinetics of drug release include the zero-order, first-order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas equations. Aliphatic polyester-based controlled drug delivery has surrounded much of the current activity in the estimation parameters of nanoparticles and stimulated additional research. Polymeric nanoparticles have potential in a wide range of applications, such as in biotechnology, vaccine systems, and the pharmaceutical industry. The main goal of this chapter is to discuss aliphatic polyester nanoparticles as drug carrier systems.",book:{id:"10882",title:"Smart Drug Delivery",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg"},signatures:"Narumol Kreua-ongarjnukool, Nopparuj Soomherun, Saowapa Thumsing Niyomthai and Sorayouth Chumnanvej"},{id:"78844",title:"Targeted Nano-Drug Delivery System to Colon Cancer",slug:"targeted-nano-drug-delivery-system-to-colon-cancer",totalDownloads:122,totalDimensionsCites:0,doi:"10.5772/intechopen.100059",abstract:"Cancer has been considered as the most cause of death in world. Employing of nanocarriers as drug delivery systems provide a platform for delivering drugs with increasing the anti-cancer efficacy, enhancing bioavailability of drugs, reducing side effects, enhancing the circulation half-life of drugs, improving the distribution of drugs and overcoming drug resistance. A number of nanocarriers have been studied as drug delivery systems for improving the treatment of cancer including liposomes, micelle, polymeric nanoparticles, carbon nanotubes, dendrimers, solid lipid nanoparticle (SLN) and nanostructure lipid carrier (NLC). In order to enhance recognition and internalization of nanocarriers by the target tissues, their surfaces can be modified with targeting ligands such as integrins, transferrin, folic acid, polysaccharides and antibodies. In this chapter, we are going to introduce the targeted nanocarriers for improving the cytotoxic action of drugs with further attempt of decreasing dose to achieve higher anticancer activity. Targeted nanocarriers would provide a promising therapeutic approach for cancer.",book:{id:"10882",title:"Smart Drug Delivery",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg"},signatures:"Eskandar Moghimipour and Somayeh Handali"},{id:"78619",title:"Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery",slug:"strategies-to-develop-cyclodextrin-based-nanosponges-for-smart-drug-delivery",totalDownloads:127,totalDimensionsCites:1,doi:"10.5772/intechopen.100182",abstract:"In recent years, the development of various cyclodextrin (CD)-based nanosponges (NSs) has gained great importance in the controlled and-or targeted release of drugs due to their versatility and simple preparation. In this chapter, an introduction of different administration routes is explained. Further, different ways to obtain CD-NSs and their classification are shown with a brief explanation of the characterization of the inclusion complexes. Finally, illustrative examples in diverse processes or diseases will be reviewed and explained to demonstrate the potential of CD-NSs. Therefore, this division will serve to compile information on CD-NSs in recent years and to illustrate to readers how to generate and apply different derivatives of interest.",book:{id:"10882",title:"Smart Drug Delivery",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg"},signatures:"Gjylije Hoti, Silvia Lucia Appleton, Alberto Rubin Pedrazzo, Claudio Cecone, Adrián Matencio, Francesco Trotta and Fabrizio Caldera"},{id:"78313",title:"Smart Drug-Delivery Systems in the Treatment of Rheumatoid Arthritis: Current, Future Perspectives",slug:"smart-drug-delivery-systems-in-the-treatment-of-rheumatoid-arthritis-current-future-perspectives",totalDownloads:204,totalDimensionsCites:0,doi:"10.5772/intechopen.99641",abstract:"Rheumatoid arthritis (RA) is a progressive autoimmune inflammatory disorder characterized by cellular infiltration in synovium causing joint destruction and bone erosion. The heterogeneous nature of the disease manifests in different clinical forms, hence treatment of RA still remains obscure. Treatments are limited owing to systemic toxicity by dose-escalation and lack of selectivity. To overcome these limitations, Smart drug delivery systems (SDDS) are under investigation to exploit the arthritic microenvironment either by passive targeting or active targeting to the inflamed joints via folate receptor, CD44, angiogenesis, integrins. This review comprehensively deliberates upon understanding the pathophysiology of RA and role of SDDSs, highlighting the emerging trends for RA nanotherapeutics.",book:{id:"10882",title:"Smart Drug Delivery",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg"},signatures:"Largee Biswas, Vikas Shukla, Vijay Kumar and Anita Kamra Verma"}],onlineFirstChaptersTotal:7},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:14,paginationItems:[{id:"82457",title:"Canine Hearing Management",doi:"10.5772/intechopen.105515",signatures:"Peter M. Skip Scheifele, Devan Marshall, Stephen Lee, Paul Reid, Thomas McCreery and David Byrne",slug:"canine-hearing-management",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82285",title:"Parvovirus Vectors: The Future of Gene Therapy",doi:"10.5772/intechopen.105085",signatures:"Megha Gupta",slug:"parvovirus-vectors-the-future-of-gene-therapy",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:38,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}]},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}]},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",biography:"Naceur M’HAMDI is Associate Professor at the National Agronomic Institute of Tunisia, University of Carthage. He is also Member of the Laboratory of genetic, animal and feed resource and member of Animal science Department of INAT. He graduated from Higher School of Agriculture of Mateur, University of Carthage, in 2002 and completed his masters in 2006. Dr. M’HAMDI completed his PhD thesis in Genetic welfare indicators of dairy cattle at Higher Institute of Agronomy of Chott-Meriem, University of Sousse, in 2011. He worked as assistant Professor of Genetic, biostatistics and animal biotechnology at INAT since 2013.",institutionString:null,institution:null}]},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null}]}]},openForSubmissionBooks:{paginationCount:6,paginationItems:[{id:"11475",title:"Food Security Challenges and Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11475.jpg",hash:"090302a30e461cee643ec49675c811ec",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"292145",title:"Dr.",name:"Muhammad",surname:"Haseeb Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",hash:"a58c7b02d07903004be70f744f2e1835",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11477",title:"Public Economics - New Perspectives and Uncertainty",coverURL:"https://cdn.intechopen.com/books/images_new/11477.jpg",hash:"a8e6c515dc924146fbd2712eb4e7d118",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 27th 2022",isOpenForSubmission:!0,editors:[{id:"414400",title:"Dr.",name:"Habtamu",surname:"Alem",slug:"habtamu-alem",fullName:"Habtamu Alem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11457",title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",hash:"8df7150b01ae754024c65d1a62f190d9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 7th 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11473",title:"Social Inequality - Structure and Social Processes",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",hash:"cefab077e403fd1695fb2946e7914942",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:14,paginationItems:[{id:"82457",title:"Canine Hearing Management",doi:"10.5772/intechopen.105515",signatures:"Peter M. Skip Scheifele, Devan Marshall, Stephen Lee, Paul Reid, Thomas McCreery and David Byrne",slug:"canine-hearing-management",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82285",title:"Parvovirus Vectors: The Future of Gene Therapy",doi:"10.5772/intechopen.105085",signatures:"Megha Gupta",slug:"parvovirus-vectors-the-future-of-gene-therapy",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:38,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",doi:"10.5772/intechopen.99671",signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:153,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78849",title:"Application of Vermicompost Fertilizer in Aquaculture Nutrition: Review",doi:"10.5772/intechopen.100326",signatures:"Sonnia Nzilani Musyoka and Rita Nairuti",slug:"application-of-vermicompost-fertilizer-in-aquaculture-nutrition-review",totalDownloads:71,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Nutrition - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11416.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"78543",title:"Pulmonary Vein: Embryology, Anatomy, Function and Disease",doi:"10.5772/intechopen.100051",signatures:"Chan I-Ping and Hsueh Tung",slug:"pulmonary-vein-embryology-anatomy-function-and-disease",totalDownloads:182,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78564",title:"Anatomy of the Rhesus Monkey (Macaca mulatta): The Essentials for the Biomedical Researcher",doi:"10.5772/intechopen.99067",signatures:"Christophe Casteleyn and Jaco Bakker",slug:"anatomy-of-the-rhesus-monkey-macaca-mulatta-the-essentials-for-the-biomedical-researcher",totalDownloads:348,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"77999",title:"Bronchus-Associated Lymphoid Tissue (BALT) Histology and Its Role in Various Pathologies",doi:"10.5772/intechopen.99366",signatures:"Tuba Parlak Ak",slug:"bronchus-associated-lymphoid-tissue-balt-histology-and-its-role-in-various-pathologies",totalDownloads:212,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78242",title:"Genomic Instability and Cyto-Genotoxic Damage in Animal Species",doi:"10.5772/intechopen.99685",signatures:"María Evarista Arellano-García, Olivia Torres-Bugarín, Maritza Roxana García-García, Daniel García-Flores, Yanis Toledano-Magaña, Cinthya Sofia Sanabria-Mora, Sandra Castro-Gamboa and Juan Carlos García-Ramos",slug:"genomic-instability-and-cyto-genotoxic-damage-in-animal-species",totalDownloads:150,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}}]},subseriesFiltersForOFChapters:[{caption:"Animal Nutrition",value:20,count:1,group:"subseries"},{caption:"Animal Science",value:19,count:13,group:"subseries"}],publishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9959",title:"Biomedical Signal and Image Processing",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9959.jpg",slug:"biomedical-signal-and-image-processing",publishedDate:"April 14th 2021",editedByType:"Edited by",bookSignature:"Yongxia Zhou",hash:"22b87a09bd6df065d78c175235d367c8",volumeInSeries:10,fullTitle:"Biomedical Signal and Image Processing",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",institutionString:"University of Southern California",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9973",title:"Data Acquisition",subtitle:"Recent Advances and Applications in Biomedical Engineering",coverURL:"https://cdn.intechopen.com/books/images_new/9973.jpg",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering",publishedDate:"March 17th 2021",editedByType:"Edited by",bookSignature:"Bartłomiej Płaczek",hash:"75ea6cdd241216c9db28aa734ab34446",volumeInSeries:9,fullTitle:"Data Acquisition - Recent Advances and Applications in Biomedical Engineering",editors:[{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9905",title:"Biometric Systems",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9905.jpg",slug:"biometric-systems",publishedDate:"February 10th 2021",editedByType:"Edited by",bookSignature:"Muhammad Sarfraz",hash:"c730560dd2e3837a03407b3a86b0ef2a",volumeInSeries:8,fullTitle:"Biometric Systems",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",institutionString:"Kuwait University",institution:{name:"Kuwait University",institutionURL:null,country:{name:"Kuwait"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8622",title:"Peptide Synthesis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8622.jpg",slug:"peptide-synthesis",publishedDate:"December 18th 2019",editedByType:"Edited by",bookSignature:"Jaya T. Varkey",hash:"de9fa48c5248dbfb581825b8c74f5623",volumeInSeries:0,fullTitle:"Peptide Synthesis",editors:[{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",institutionString:"St. Teresa’s College",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",slug:"computer-vision-in-dentistry",publishedDate:"September 18th 2019",editedByType:"Edited by",bookSignature:"Monika Elzbieta Machoy",hash:"1e9812cebd46ef9e28257f3e96547f6a",volumeInSeries:7,fullTitle:"Computer Vision in Dentistry",editors:[{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",editedByType:"Edited by",bookSignature:"Anna Nowinska",hash:"da2c90e8db647ead30504defce3fb5d3",volumeInSeries:6,fullTitle:"Novel Diagnostic Methods in Ophthalmology",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska",profilePictureURL:"https://mts.intechopen.com/storage/users/261466/images/system/261466.jpeg",institutionString:"Medical University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",institutionString:"University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}}]}},subseries:{item:{id:"6",type:"subseries",title:"Viral Infectious Diseases",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11402,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null,series:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188"},editorialBoard:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}},{id:"188219",title:"Prof.",name:"Imran",middleName:null,surname:"Shahid",slug:"imran-shahid",fullName:"Imran Shahid",profilePictureURL:"https://mts.intechopen.com/storage/users/188219/images/system/188219.jpeg",institutionString:null,institution:{name:"Umm al-Qura University",institutionURL:null,country:{name:"Saudi Arabia"}}},{id:"214235",title:"Dr.",name:"Lynn",middleName:"S.",surname:"Zijenah",slug:"lynn-zijenah",fullName:"Lynn Zijenah",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSEJGQA4/Profile_Picture_1636699126852",institutionString:null,institution:{name:"University of Zimbabwe",institutionURL:null,country:{name:"Zimbabwe"}}},{id:"178641",title:"Dr.",name:"Samuel Ikwaras",middleName:null,surname:"Okware",slug:"samuel-ikwaras-okware",fullName:"Samuel Ikwaras Okware",profilePictureURL:"https://mts.intechopen.com/storage/users/178641/images/system/178641.jpg",institutionString:null,institution:{name:"Uganda Christian University",institutionURL:null,country:{name:"Uganda"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"82124",title:"Assessment of Diversity, Growth Characteristics and Aboveground Biomass of Tree Species in Selected Urban Green Areas of Osogbo, Osun State",doi:"10.5772/intechopen.104982",signatures:"Omolara Aremu, Olusola O. Adetoro and Olusegun Awotoye",slug:"assessment-of-diversity-growth-characteristics-and-aboveground-biomass-of-tree-species-in-selected-u",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}}]},publishedBooks:{paginationCount:7,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Dr.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:null,institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/103961",hash:"",query:{},params:{id:"103961"},fullPath:"/profiles/103961",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()