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\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
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\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
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\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
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\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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It involves the systematic investigation of existing social, ecological, and geological conditions and processes in the landscape, and the design of interventions that will produce the desired outcome. The scope of the profession includes: urban design; site planning; town or urban planning; environmental restoration; parks and recreation planning; visual resource management; green infrastructure planning and provision; and private estate and residence landscape master planning and design - all at varying scales of design, planning and management. This book contains chapters on recent developments in studies of landscape architecture. For this reason I believe the book would be useful to the relevant professional disciplines.",isbn:null,printIsbn:"978-953-51-0654-8",pdfIsbn:"978-953-51-5304-7",doi:"10.5772/2761",price:139,priceEur:155,priceUsd:179,slug:"landscape-planning",numberOfPages:374,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"3c7b088d1bfbcf17d7f2fe6f47137af2",bookSignature:"Murat Ozyavuz",publishedDate:"June 13th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/2406.jpg",keywords:null,numberOfDownloads:66548,numberOfWosCitations:50,numberOfCrossrefCitations:19,numberOfDimensionsCitations:65,numberOfTotalCitations:134,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 25th 2011",dateEndSecondStepPublish:"November 18th 2011",dateEndThirdStepPublish:"January 27th 2012",dateEndFourthStepPublish:"February 26th 2012",dateEndFifthStepPublish:"April 26th 2012",remainingDaysToSecondStep:"10 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz",profilePictureURL:"https://mts.intechopen.com/storage/users/93073/images/549_n.jpg",biography:"Assoc. Prof. Dr. Murat Ozyavuz was born in 1976 in Turkey and lived there until coming to Ankara (Turkey) in 1999. He studied Landscape Architecture at the Ankara University and obtained B.S. degree in 1999. He obtained his M.S. and Ph.D. degrees from the Landscape Architecture Department of Institute of Natural and Applied Sciences in 2003 and July 2008, respectively (M. S. Thesis, Arboretum Planning Principles and Thrace University Güllapoğlu Arboretum Landscape Planning Studies, Ph.D. thesis, Planning of İğneada – Demirköy Part of Yildiz Mountains as a Biosphere Reserve). During his Ph.D. studies, he mostly worked on Landscape Planning, Protected Areas, Geographic Information Systems and Remote Sensing. Now, Dr. Ozyavuz is an Associate Professor at the Department of Landscape Architecture, Faculty of Fine Arts, Design and Architect, Namık Kemal University. He has many national and international publications and has worked on many research projects.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Namık Kemal University",institutionURL:null,country:{name:"Turkey"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"849",title:"Landscape Ecology",slug:"landscape-ecology"}],chapters:[{id:"37552",title:"Protected Areas",slug:"protected-areas",totalDownloads:2207,totalCrossrefCites:0,authors:[{id:"93073",title:"Dr.",name:"Murat",surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}]},{id:"37553",title:"Land Use/Cover Classification Techniques Using Optical Remotely Sensed Data in Landscape 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"73567",title:"Current State-of-the-Art of Clustering Methods for Gene Expression Data with RNA-Seq",doi:"10.5772/intechopen.94069",slug:"current-state-of-the-art-of-clustering-methods-for-gene-expression-data-with-rna-seq",body:'In recent years, RNA-seq based on Next generation Sequencing has become an attractive alternative for conducting quantitative analysis of gene expression. This approach offers a number of advantages compared to microarray analysis such as the discovery of novel RNA species (RNA-seq is not limited by prior knowledge of the genome of the organism, it can be used for the detection of novel transcripts), the higher sensitivity for genes expressed either at low or very high level and the unbiased approach compared to microarrays that are subject to cross-hybridization bias. Overall, RNA-seq is a better technique for many applications such as novel gene identification, differential gene expression, and splicing analysis.
The principle of RNA-seq is based on high-throughput next generation sequencing (NGS) technologies. The first step in the technique involves converting the population of RNA to be sequenced into cDNA fragments with adaptors attached to one or both ends, each molecule is then sequenced to obtain either single end short sequence reads or paired end reads [1]. These reads are stored in fastq files formats and consist of raw data for many analysis pipelines (Figure 1).
RNA sequencing.
The primary objective of this chapter is to present algorithms for clustering gene expression data from RNA-seq. Therefore, in the first section, we will describe the different steps of the gene expression analysis workflow from preprocessing the raw reads to gene expression clustering and classification. In the second part of the chapter we will describe traditional, model-based and machine learning clustering methods for gene expression data, then we will conclude this chapter with a study for clustering samples of four public datasets from recount2, using different clustering methods and also evaluating the performance of each one using the adjusted rand index (RDI) and accuracy.
RNA-seq has become a common tool for scientists to study the transcriptome complexity, and a convenient method for the analysis of differential gene expression. A typical RNA-seq data analysis workflow starts by preprocessing raw reads for contamination removal and quality control checks. The following step is to align the reads to a reference genome, or to make a de novo assembly if there is not any. Following the alignment, the quantification step aims to quantify aligned reads to produce a count matrix to use as entry data for Differential Expression (DE) analysis. Normalization and DE analysis normally go together as most of the methods have built-in normalization and accept only raw count matrix. For this study, we are more interested in the clustering step, we will perform Normalization of the raw counts separately and do the clustering without going through differential gene expression analysis. In the following section we describe with more details each step of the pipeline (Figure 2).
RNA-seq data analysis workflow.
Preprocessing raw reads consist of checking the quality of the reads, adapters trimming, removal of short reads and filtering bad quality bases. Tools like FastQC can generate a report summarizing the overall quality of the sequence information [2]. Based on this report we can determine how the quality trimming should be set up. Trimmomatic is one of many tools used to clean up the raw data. It can be used to remove adapters from the reads, trim off any low-quality bases at the ends of reads, and filter short reads that can align to multiple locations on the reference genome. Once the trimming step is done, it is a good practice to recheck the quality of the reads by rerunning FastQC.
Now that we have explored the quality of our raw reads, we can move on to read alignment. Read alignment is one of the first steps required for many different types of analysis. It aims to map the huge number of short RNA sequences generated by NGS instruments (reads) to a reference genome in order to identify the correct genomic loci from which the read originated. In RNA-seq, alignment is a major step for the calculation of transcript or gene expression levels; several splice-aware alignment methods have been developed for RNA-seq experiments such as STAR, HISAT2 or TopHat. These aligners are designed to specifically address many of the challenges of RNA-seq data mapping using a strategy to account for spliced alignments [3, 4, 5].
Quantification of gene expression is to count the number of reads that map to each gene using methods such as HTSeq-count, FeatureCounts or kallisto [6, 7, 8]. This step is crucial if we want to do a gene differential expression analysis, which means to identify genes (or transcripts), if any, that have a statistically significant difference in abundance across the experimental groups or conditions.
The read counts generated in the quantification step need to be normalized to make accurate comparisons of gene expression between samples or when doing an exploratory data analysis. Several normalization methods are used for this purpose such as CPM (counts per million), TPM (transcripts per kilobase million), RPKM/FPKM (reads/fragments per kilobase of exon per million reads/fragments mapped), DESeq2’s median of ratios and EdgeR’s trimmed mean of M values (TMM) [9].
Cluster analysis techniques have proven to be helpful to understand gene expression data by uncovering unknown relationships among genes and unveiling different subtypes of diseases when it comes to clustering biological samples [10]. In the following section, we present methods for sample-based and gene-based clustering, starting with traditional methods used after data transformation then model-based clustering for data generated using a combination of probability distributions (Figure 3).
Cluster analysis of RNA-sequencing data.
Traditional clustering algorithms like hierarchical clustering and k-means cannot be directly applied to RNA-seq count data, to apply these methods for cluster analysis of RNA-seq data, that tend to follow an over-dispersed Poisson or negative binomial distribution, we need to transform the data in order to have a distribution closer to the normal distribution. In the following section, we present popular methods for data transformation:
Logarithmic, widely used method to deal with skewed data in many research domains, often used to reduce the variability of the data and make the data conform more closely to the normal distribution. However, it was demonstrated in [11], that in most circumstances the log transformation does not help make data less variable or more normal and may, in some circumstances, make data more variable and more skewed.
Variance stabilizing transformation: This method was used to transform microarray data to stabilize the asymptotic variance over the full range of the data [12].
Eight data transformations (r, r2, rv, rv2, l, l2, lv, and lv2) for RNA-seq data analysis were proposed in [13], these methods deal with the two common properties when it come to the count matrix generated in the quantification step, Sparsity and Skewness; Sparsity means that many counts in the count matrix are zero. Skewness means that the histogram of all counts in the count matrix is usually skewed.
Hierarchical clustering method is the most popular method for gene expression data analysis. In hierarchical clustering, genes with similar expression patterns are grouped together and are connected by a series of branches (clustering tree or dendrogram). Experiments with similar expression profiles can also be grouped together using the same method. This clustering technique is divided into two types: agglomerative and divisive. In an agglomerative or bottom-up clustering method each observation is assigned to its own cluster. In a comparative study on Cancer data [14], three variants of Hierarchical Clustering Algorithms (HCAs): Single-Linkage (SL), Average-Linkage (AL) and Complete-Linkage (CL) with 12 distance measure have been used to cluster RNA-seq Samples. The same methods will be used in our study along with hierarchical clustering with Poisson distribution [15].
K-medoids is a partitional clustering algorithm proposed in 1987 by Kaufman and Rousseeuw. It is a variant of the K-means algorithm that is less sensitive to noise and outliers because it uses medoids as cluster centers instead of means that are easily influenced by extreme values. Medoids are the most centrally located objects of the clusters, with a minimum sum of distances to other points. After searching for k representative objects in a data set, the algorithm which is called Partitioning Around Medoids (PAM) assigns each object to the closest medoid in order to create clusters. Like in k-means the number of classes to be generated needs to be specified.
Yaqing Si et al. described a number of Model based clustering methods for RNA-seq data in their paper [16], these methods assume that data are generated by a mixture of probability distributions: Poisson distribution when only technical replicates are used and Negative binomial distribution when working with biological replicates. The first method they proposed is a model-based clustering method with the expectation-maximization algorithm (MB-EM) for clustering RNA-seq gene expression profile. The expectation-maximization algorithm is widely used in many computational biology applications, the authors in [17] explain how this algorithm works and when it is used. The second method is an initialization algorithm for cluster centers, the idea behind this method is to randomly choose one cluster center and then gradually add centers by selecting genes based on the distance between each gene and each of the selected centers. Two other stochastic algorithms have been proposed in this paper, a stochastic version of the expectation-maximization algorithm and a classification expectation maximization algorithm with simulated annealing. The last method in this paper is a model-Based Hybrid-Hierarchical Clustering Algorithm, it does not require to pre-specify the number of clusters to be generated as it is required by the previous methods. The authors propose to use agglomerative clustering starting with k0 clusters to speed up the calculation, then, it repeatedly identifies the two clusters that are closest together and merges the two most similar clusters. This method was called hybrid because it combines two steps: Obtaining the initial K0 clusters using one of the previous described algorithms then agglomerative clustering to build the hierarchical tree.
Classification in machine learning is a supervised learning approach in which the algorithm learns from the data given to it and makes new observations, then applies the conclusions to new data. Clustering on the other hand is an unsupervised learning problem for grouping unlabeled features. The learning algorithm that learns the model from the training data and maps the input data to a specific class is called classifier, in the following section, we briefly present three widely used classifiers for grouping RNA-seq data.
Random forests (RF): an ensemble method that trains a large number of individual decision trees, each tree gives a class prediction, the category that wins the majority votes is used as the final decision of the random forest model. The algorithm can perform both classification and regression tasks and has better accuracy among current algorithms.
Support Vector Machine (SVM): one of the most popular supervised learning models, used for both classification and regression, the data points are separated using an optimal hyperplane or a set of hyperplanes in a multidimensional space with the maximum possible margin between support vectors.
Poisson linear discriminant analysis: an approach used for the classification and clustering of RNA-seq data using a Poisson log linear model [15].
To test these algorithms, we used MLSeq (Machine learning interface for RNA-sequencing data) which is an R package including more than 80 machine learning algorithms and a pipeline to classify RNA-seq data including normalization, filtering and transformation steps [18].
Deep learning is also a technique that can be used to learn better data representation of high-dimensional data. The two recently published surveys [19, 20] present a taxonomy of existing deep clustering algorithms, by describing the different Neural Network Architecture that exists for feature representation, clustering loss function and Performance Evaluation Metrics for Deep Clustering. In [20], the authors categorize current deep clustering models into following three categories:
Auto-Encoders Based Deep Clustering
CDNN-Based Deep Clustering (feed-forward networks trained only by specific clustering)
Generative Adversarial Network (GAN)
These approaches are already used in the analysis of RNA-seq data, for example, an unsupervised deep embedding algorithm that clusters single cell (scRNA-seq) data was proposed in [21], another paper use a Lasso model and a multilayer feed-forward artificial neural network to analyze RNA-Seq gene expression data [22]. In [23], the authors used a Deep Neural Network model from the R package h2o for cancer data classification and in [24], ladder networks were used for gene expression classification.
Clustering algorithms and software packages corresponding to the algorithms are shown in Table 1.
Methods | Implementation in R |
---|---|
Hierarchical clustering | hclust() function in “stats” |
k-means | “cluster”, “factoextra” |
k-medoids | “cluster”, “factoextra” |
SOM | “kohonen” |
Model-based clustering with the expectation-maximization algorithm (MB-EM). Stochastic version of the expectation-maximization algorithms (Deterministic annealing (DA) algorithm). Classification expectation maximization (CEM) algorithm with simulated annealing (SA). | “MBCluster.Seq” |
Machine learning algorithms | “MLSeq” |
Clustering algorithms and software packages corresponding to the algorithms.
Recount2 is a multi-experiment resource of analysis-ready RNA-seq gene and exon count datasets. It contains 2041 different studies and over 70,000 human RNA-seq [25]. We selected for our study four different datasets based on the number of samples and the number of classes. We then performed sample-based clustering on each dataset and compared the results to the classes in the phenotype table in recount2 to evaluate the performance of each method. The methods used to classify the data are 3 subtypes of the hierarchical clustering with the Euclidean distance, hierarchical clustering with a Poisson model and k-medoids.
Description of the four datasets from recount2 is shown in Table 2.
Dataset (accession) | Number of samples | Number of classes | Classes |
---|---|---|---|
SRP032789 | 20 | 4 | 17 breast tumor samples of three different subtypes:
|
SRP049097 | 54 | 4 | 3 subtypes of Leiomyosarcoma:
|
SRP042620 | 168 | 6 |
|
SRP044668 | 94 | 3 |
|
Description of the four datasets from recount2.
There are several similarity measures for cluster evaluation, we chose to work with the adjusted Rand index which is the corrected-for-chance version of the Rand index. It is a measure used in data clustering to evaluate the performance of a clustering method, by comparing the results of a clustering algorithm against known classes from external criteria [26]. In our study, we performed different sample-based classification method on four different datasets, after that, we compared the results to the class labels we associated to each sample based on the field “characterization of the samples” in the phenotype table in recount2, then we used the ARI for cluster validation.
Figures 4–6 are examples to show the standard deviation of the transformed data, across samples, against the mean, using the shifted logarithm transformation, the regularized log transformation and the variance stabilizing transformation.
Standard deviation of the transformed data using the shifted logarithm transformation.
Standard deviation of the transformed data using the regularized log transformation.
Standard deviation of the transformed data using the variance stabilizing transformation.
Three widely used machine learning algorithms were used for the classification of the four datasets, Random forests, support vector machine and Poisson linear discriminant analysis. To perform this analysis, we first split the data into two parts as training and test sets, with 70% of samples for the training dataset, and the remaining 30% samples for the testing dataset, the training set is used to fit the parameters of the model, that is used thereafter to predict the responses for the observations in the test dataset. Normalization was applied with Deseq median ratio method and the variance stabilizing transformation was applied for the normalization of the dataset. The model was trained using 5-fold cross validation repeated 2 times. The number of levels for tuning parameters is set to 10.
All experiments are performed on a machine with 16 GB RAM, 1024 GB hard disk running with a windows operating system and MLSeq R package.
Clustering the samples of the three datasets to the sub-classes defined in the phenotype table of recounts2 was not easy. We first tried to visualize the separation between the subtypes using principal component analysis (Figures 7 and 8–10), then using 4 variants of the hierarchical clustering and k-medoids we classified the samples of each dataset (Figures 11 and 12 show the hierarchical clustering plots of the dataset SRP032789). The performance of the 5 methods was different depending on the dataset (Tables 3–5), making it impossible to make a general system of recommendation. However, we can see that the k-medoid method has relatively better performance than the other methods for all the datasets. In the second part of the study, we compared a few machine learning methods used for the classification of RNA-seq data. The performance of the models surpasses the classical methods used before, also RF and PLDA performed better than SVM which does not perform very well when the data set is large and has noise. Note that the model accuracies given in this study should not be considered as a generalization. The results can depend on several criteria: normalization and transformation methods, gene-wise overdispersions, outliers, number of classes etc. (Tables 6–11).
PCA of data from the study SRP032789.
PCA of the data from the study SRP049097.
PCA of the data from the study SRP042620.
PCA of the data from the study SRP044668.
Dendrograms obtained for the dataset from SRP032789 study using three variants of the hierarchical clustering method with the Euclidean distance.
Dendrograms obtained for the dataset from the study SRP032789 using the hierarchical clustering method with the Poisson distance.
hclus (complete) | hclust (single) | hclust (average) | hclust (complete) | k-medoids |
---|---|---|---|---|
Euclidean | Euclidean | Euclidean | Poisson distance | Euclidean |
0.4146015 | 0.3818763 | 0.4146015 | 0.4146015 | 0.6798897 |
Performance of clustering methods (SRP032789).
hclus (complete) | hclust (single) | hclust (average) | hclust (complete) | k-medoids |
---|---|---|---|---|
Euclidean | Euclidean | Euclidean | Poisson distance | Euclidean |
0.02880412 | −0.003409256 | 0.0005777741 | 0.1874828 | 0.2791547 |
Performance of clustering methods (SRP049097).
hclus (complete) | hclust (single) | hclust (average) | hclust (complete) | k-medoids |
---|---|---|---|---|
Euclidean | Euclidean | Euclidean | Poisson distance | Euclidean |
0.1944569 | 0.005551586 | 0.1285448 | 0.1468464 | 0.2579758 |
Performance of clustering methods (SRP042620).
hclus (complete) | hclust (single) | hclust (average) | hclust (complete) | k-medoids |
---|---|---|---|---|
Euclidean | Euclidean | Euclidean | Poisson distance | Euclidean |
0.2379903 | −0.007755123 | 0.399417 | 0.2657942 | 0.3771837 |
Performance of clustering methods (SRP044668).
Classifier | Accuracy | Kappa |
---|---|---|
rf | 1 | 1 |
SVM | 0.6667 | 0.5 |
PLDA | 1 | 1 |
Classification results for SRP032789 data.
Classifier | Accuracy | Kappa |
---|---|---|
rf | 0.8235 | 0.765 |
SVM | 0.7647 | 0.6909 |
PLDA | 0.7647 | 0.6866 |
Classification results for SRP049097 data.
Classifier | Accuracy | Kappa |
---|---|---|
rf | 0.9412 | 0.9249 |
SVM | 0.5882 | 0.4685 |
PLDA | 0.7843 | 0.7267 |
Classification results for SRP042620 data.
Classifier | Accuracy | Kappa |
---|---|---|
rf | 0.8214 | 0.7271 |
SVM | 0.6786 | 0.5218 |
PLDA | 0.7143 | 0.5573 |
Classification results for SRP044668 data.
SRP032789 | SRP049097 | SRP042620 | SRP044668 | |
---|---|---|---|---|
rf | 176.67 | 781.31 | 4234.89 | 1412.19 |
SVM | 1080.92 | 2333.52 | 6645.21 | 1597.89 |
PLDA | 31.45 | 60.93 | 234.98 | 72.66 |
Computational time in seconds.
The authors declare no conflict of interest.
Recently there has been raging debate regarding changing the geo-political designation of Portmore, Jamaica, from a municipality to a parish. The historical development of Portmore is intrinsically tied to Kingston. Portmore’s development began in the early seventeenth century and has developed from being a single community into a vast network of housing schemes. Some of the early communities include Queens Town, now renamed Edgewater and Port Henderson. Queens Town was established after the 1692 earthquake, which destroyed Port Royal. This community was established as a twin city to Kingston but was destroyed by a storm surge in 1722. Since its inception, Portmore as served as a dormitory of Kingston. In fact, by Jamaican government’s definition Portmore is included in the designation of the Kingston Metropolitan Area (KMA) and by extension an agglomeration of Kingston, the capital of Jamaica.
The major justification, for a change in geo-political status, offered by the government representatives, is that parish status would allow for greater autonomy for the elected officials from Portmore. The push for autonomy is influenced by the fact that the population and communities in Portmore increased since 2002 when the area was first designated as a municipality. As reported in the Jamaica Daily Gleaner on December 16, 2020, the communities in Portmore increased from 22 in 1991 to 40 communities in 2001 with the construction of several housing schemes, including that of Greater Portmore.
This chapter will attempt to shed light on the relevant explanations for designating or creating urban agglomeration for the purpose of administration and governance in the case of the largest urban space in Jamaica. Understanding the evolution of the theoretical discourse in urban planning and urban economics can provide a lens through which to examine the efficacy of the proposed geo-political designation, the intergovernmental relationship associated with the geo-political designation, particularly as it relates to autonomy, and the allocation of resources for the provision of local government services. This understanding will help to direct the decision makers as to the most appropriate designation for Portmore given its current realities and importance of implementing measures to support decentralization and autonomy at the local level for major urban areas.
Ebenezer Howard, pioneering urban planner, offers one of the earliest works on designation of urban areas. Howard, in his 1902 seminal writing,
An exploratory approach was used to examine the case of Portmore as a Municipality and the efficacy of the proposed change in the geo-political designation from a municipality to a parish. In this regard, the first objective was an in-depth look at the case of Portmore with specific emphasis on the socio-economic, political, legislative, and relevant policy arrangements.
Specifically, detailed information on the proposed change, relevant legislative documents, existing policies, available reports, and prior research were assembled and studied.
The review took account of the existing context of the Municipality of Portmore and its connection to the Kingston Metropolitan Area (KMA), details of the current and proposed geo-political arrangement, the rationale for the proposed changed and the readiness of Portmore for the proposed change from municipality to parish status. In addition to this, economic roles, and functions of the Municipality of Portmore in relation to the neighboring urban centers, the academic literature on local government reform, public financing, urban economics, and urban planning provided a basis for objectively interrogating the proposed change. This also informed the analysis and discussion of the existing fiscal relationships between the local authorities and central government and narrow down key considerations for the government and key stakeholders in determining the way when considering changing sub-national geo-political status. The existing legislative and policy environments and the implications for sustainable development also guided the study.
One of the most recent discourses on geo-political treatment of large, urbanized areas is presented by Fang [4]. Fang suggests that urban agglomerations are very different from the simple clustering of similar administrative units or geographic location. Instead, urban agglomeration is an emerging urban spatial form that is driven by concentrated industries and populations, a highly connected transportation network, an enhanced central city and favorable regional incentive policies. Urban agglomerations are evidently a product of the late stages of metropolitan development. Furthermore, “one can only claim that there is an urban agglomeration when the networks grow in strength and frequency and the socioeconomic ties among the central and peripheral cities become more integrated Fang and Hu ([2], p. 133).
Cities are characterized by urban agglomeration as there exists agglomeration economies. Agglomeration economies are generally either pecuniary or technological in nature [5]. These are resource advantages. The former can result from a large and diverse labor market. Thus, firms in the KMA that rely on Portmore for its labor supply can enjoy greater productivity through lower labor and transportation costs due to proximity to work and stronger competition for jobs. This is of major consideration when other urban areas such as May Pen or Old Harbor are considered (see Map showing designated towns and areas in Jamaica). Portmore is one of the largest residential settlements in Jamaica and the English-speaking Caribbean. It is also one of the fastest growing urban areas in the island. However, as aforementioned, Portmore has been a dormitory for Kingston. Its main pull factors are proximity to Kingston and its affordable housing stock, in comparison to the KMA.
Technological agglomeration economies result from knowledge spill-over across and within industries. It implies thicker upstream and downstream linkages between economic activities in an urban area. To capitalize on these economies, local governments, with the autonomy to design and attract the right kind of industries will most likely promote the appropriate mix of land uses and production linkages that will trap the benefits of knowledge sharing and the cross-fertilization of ideas, inputs, and outputs, that will maximize returns to firms and by extension to the locality.
Presently, in the Municipality of Portmore, the leading sources of private-sector income are retail and services. There is also a fairly recent trend of a growing number of Business Process Outsourcing (BPO) firms in the Municipality. In addition to this, the steady demand for housing in the area stimulates growth in new outputs of housing and commercial properties. However, the strength of linkages between these economic activities is questionable. For example, there is no evidence of strategic clustering of industries and spatial concentration of suppliers, supply chains, complementary industries, and local institutions to maximize on locational competitiveness [6].
In fact, it is arguable that the informal economic activities in the area perform fairly well in establishing linkages when compared to the formal activities. It must be noted that although the informal sector is a source of employment and income for many residents, it is not a source of revenue for the government. Further, with the exception of the Municipality’s fishing industry, these informal economic activities are diverse and very difficult to locate. Strategic clustering in any urban agglomeration is significant as land use patterns are substantial to the maximization of the benefits of agglomeration economies.
A further consideration is the potential intercity dynamics—The economic competition between Kingston and Portmore. If Portmore fails to create and supply the jobs to match its endowment of labor, the region will continue to serve as a dormitory for Kingston’s labor input. An alternative arrangement to serving as a dormitory is for Portmore to use its labor supply as a source of competitive advantage to attract the type and quantity of productive activities to the area. According to Reilly’s [7] law of gravitation the capacity of two cities to attract retail spending from the catchment area in between them is dependent on the size and the square of the distance from any location between the two cities. However, while large population and labor supply is a potent pull factor for firms, the existing spending power in the locality is also an important consideration. Arguably, higher income cities are more likely to attract higher income residents which makes them more attractive to both large and small businesses. Harvey and Jowsey [8] noted that:
When these are taken account of, the pull-factor of a more affordable housing stock in Portmore which makes housing more accessible to residents in lower income groups, may not necessarily translate to making the area more attractive to more businesses. Therefore, Portmore’s current ability to attract the kind of economic activities in the quantities that will generate linkages and capitalize on economies, and which will provide job opportunities for its residents is questionable.
As mentioned earlier, Portmore lacks the level of diversity in economic activities and the type of upstream and downstream linkages to fully capitalize on the benefits of agglomeration economies that will likely be needed for the economic viability of the area if it is designated as a parish. However, other considerations include the quality and quantity of its urban infrastructure and services, particularly when compared to neighboring areas. Local governments in Jamaica and throughout the world are preoccupied with identifying the necessary funding to address these issues. It is likely to be more challenging should Portmore be designated parish, to generate the necessary resources to support the demand on its resources which would necessitate increasing investments in some public goods and services and land resources.
The prospects of maximizing scale economies in Portmore will likely depend on intensifying land use in the area. However, given the relatively inelastic supply of land for the various uses in the area, more intensive use will invariably take the form of high-rise developments. High-rise development is the most likely response to increased demand for residential or commercial properties in more urbanized areas where suitable land is relatively scarce. On this point, Portmore’s geographical location makes it vulnerable to natural disasters. Consequently, building sound and resilient high-rise structures are likely to be costly. Whereas the land input may be minimized, the capital input would likely be substantial, such that these developments would not be feasible if the cost of capital is not sufficiently low.
Further, if the designation of parish results in altering the land use patterns in Portmore in pursuit of agglomeration economies, through a larger, more diversified economic base, then as mentioned earlier, the demand for services, facilities and urban infrastructure will likely increase. Any foreseeable increase demand on the services and infrastructure must be matched by the revenues generated by economic activities in the area. For this to be feasible, the marginal benefits from additional users in the area should equate the change in costs for the provision of public goods and services by the local government. Public goods are non-rivalry and non-excludable and cannot be efficiently allocated through the market mechanism. These include some levels of school and educational facilities, safety and security services, access to and maintenance of recreational facilities and markets, sewers and sanitation, public health facilities, and roads.
It must be noted, that in countries with decentralized governments, the market could be relied upon to smooth out differences in the marginal costs and benefits of the changes that may accompany a change in the geo-political designation from a municipality to a parish. However, even in a democratic society, as long as central governments have a high level of autonomy over revenues and the sources of income, local governments are not empowered to make the necessary adjustments to manage its provision of public goods and services. This generally results in sub-optimal allocations at the local level. Therefore, the designation of parish may be accompanied by increased fiscal responsibility but not necessarily by the level of autonomy and financial independence of the local government that is needed to avoid welfare loss to its residents.
To evaluate the extent of their financial independence if the designation is changed to parish, Portmore’s local government should assess the following:
The amount of actual revenue from taxes and fees that will be available to the local authority.
The extent and efficiency of its sources of income.
The real power and methods by which the local government can influence increase in fees to cover rising costs.
The possibility of incurring debt as part of financial autonomy and financial management.
The strength and size of the economic base of the locality.
Level of diversity in economic activities of the locality.
With the proposed change of the geo-political designation of the area, the arrangements for financing of, for example, public goods and services will necessarily be changed. Thus, the amount of actual revenue from taxes and fees and how these would be allocated to the newly established parish are pertinent to the decision. It must be noted that property taxes and council fees are the primary sources of revenue for local governments in Jamaica. However, property tax rates are set by central government and it is calculated on the unimproved land value, the buildings are not taxed. Consequently, increased tax revenues to the local authority are largely dependent on the demand for land. A noteworthy point on this topic is that the costly re-valuation exercise that is required to capture gains from appreciation in property value, is arguably not undertaken as often as is needed for local governments to capture its share of the gains in property value that is needed to finance investments in public goods and services to support residents and businesses in the area. In fact, disinvestment, and a lack of maintenance of public goods and services by local governments as they rely on this income to cover some of these costs is not far-fetched.
The corollary of the foregoing is that alongside the potential benefits of parish designation touted by government officials, decision-makers are tasked to take an objective look at the Municipality’s opportunities to expand and deepen its economic activities to cover both internal and external costs. This objective evaluation should include serious considerations as to whether or not the type, size and diversity of current and potential economic activities in Portmore can sufficiently capture the benefits of agglomeration economies and what changes will be made to empower the local government to manage the fiscal affairs of the proposed parish.
In Jamaica, as in most developed country that have adopted a market driven economy, the bulk of funding for local government services is appropriated by Central government. The assumption behind central government’s control of funding for local services has been influenced by the notion of achieving economies of scale and efficiency in the delivery of these services.
For a small island state such as Jamaica, with a parliamentary system almost akin to a unitary form of government, centrally controlled funding for local government services might seem logical at first. However, further examination of income and expenditure at the local level reveals that services are duplicated across agencies and there are no clear lines of accountability towards the allocation of these funds.
Historically there has been a “tug-of war” between the national government and the local authority about who should bear the cost for delivering services. Central to the conflict is the control of powers. The central government wants to maintain control and access to revenues which are generated at the local level. In Jamaica, like any other modern democracy there is the tension between the nation state and local authorities, as the officials at the local level become more concerned with increasing their share of powers and resources visa-vis the claims of other localities and the national state ([9], p. 35).
There are several treatises on local government reform which Jamaica can adopt to carry out the much-needed reform. One line of argument, at the broader macro level, placed the discourse into two camps: neo-Marxist left and the neo-conservative right. The neo-Marxist argues that growth and decline at the local level, particularly in the urban areas is influenced by decisions made at the national level as a function of economic forces [9]. The neo-conservatives believe that decisions at the local level should be left to ‘invisible’ force of the market and those local areas that can grow as a result will do so. Central to both lines of arguments is that national government can and does influence the growth and decline of local municipalities. This is the main point carried by political economists.
Another theory on local government reform, while arguing from the perspective of market forces, introduces a more complex variable, that of globalism. According to Clarke [10] “global economic change process general transcend scale, yet in some instances are very sensitive to local contextual factors, including state actions” ([10], p. 12). According to Clarke, local officials over the world operate under heightened conditions of economic and political uncertainty. They have new social and economic roles and responsibilities that are unanticipated. Local officials must reconstruct relations between public and private sector at the local level, in the context of the “new globalism” in addition to concentrating on providing the most basic governance issues.
Proponents of the “new global reality of local government” further argue that to the extent that the legitimacy of democratic regimes is tied to economic performance rather than governance based on civic values, the new localized state suggest a subordination of political will to private interest, particularly at the local level. Furthermore, democratization trends at the national level have left unclear the autonomy of local government relative to other ties. Local governments are victims of structural adjustment programmers in developing countries, national government focus on complying with international debt programmer rather than providing financial and administrative resources for the delivery of local services.
Attempts have been made at redistributing local influence. This is evidence by increased participation of the citizenry in the decision-making process. However, full participation is hampered by the fact that those who tend to “benefit” from the new privatization of services is the party ‘faithful’s’ and the often-gained new position of influence in newly privatized local government. Local government’s inability to carry out new roles and functions are constrained by “poor capital” and uneven development patterns. Uneven allocation restricts the ability of local governments to compete for new private investment.
New localism generates extensive competition among states and between local areas. This heightened level of competition has been known to exacerbate uneven development. In this era of globalism, local leaders must now move in a decision-making arena where pivotal investors operate at global scales, and at a magnitude and pace that defies local involvement. However, local leaders are asked to perform in this market as entrepreneurs under public constraints. National government also influences local leaders’ performance in the global context.
The national government is wary of the fiscal and political consequences of proactive local development efforts. The local decision makers are also limited by the knowledge base and skills to act as public entrepreneurs. In the past local councilors were tied to their local context and the skills there are less likely to transfer when dealing in a global context. Schoburg [11] supports this position. She argues that most local government authority in Jamaica are hampered by an organizational framework built on values that are no longer compatible with contemporary leadership and management technologies or development norms. Furthermore, the operations of local government in the Caribbean and in Jamaica specifically, lack a culture of high performance ([11], p. 19).
Peterson [12] also acknowledged constraints associated with local government. He is of the view that local governments are limited by their ability to implement and redistribute polices or social welfare type policies. These local decision-makers fear that this would encourage the movement of capital. Instead, local decision-makers are likely to seek out developmental policies that serve to increase local capital base. In their view, this represents a maximization of “the public interest.” Stone [13], among others, expanded Peterson’s argument by pointing out that the political culture of the locality also plays a significant role in the policies developed for that locality. The influence of political culture is most evident in policy making at the local government level here in Jamaica.
Recognizing the limitations associated with resource mobilization, local governments have opted to privatize the provision of certain services. Theories of privatizing local government services have also influenced the discourse on local government reform. Boyne [14] in his analysis of local government reform in Great Britain, points out that since the 1980s there has been efforts to privatize government services. This effort of privatizing is driven by the belief that the market can produce goods and services more efficiently. It is also driven by the belief that resource decisions are seen as more rational when left to individuals who choose alternatives based on their own preferences through a market bidding process. Market like disciplines will prevent consumers of public goods and services from over consuming their services and smooth out inefficiencies in the provision of these goods and services.
The historical overview of local government reform in Great Britain, provided by Boyne [14] mirrored that of Jamaica. Boyne notes that in Great Britain, local authorities have been shaped by central government into service providers whose primary role lies in supplementing the welfare state rather than economic production.
The industrialists shaped municipal policies to give their businesses the competitive edge. As large companies expanded, they began to focus on national and international base of power and gave limited attention to local politics. The national government oftentimes step in and control the provision of infrastructure and social services. In the 1980s, like Great Britain, there was restricted funding for local government in Jamaica. To address funding constraints, the more independent local government in Great Britain developed strategies for economic development. Greater London Council and the more radical councils developed schemes for allocating funds to stimulate local businesses.
In Great Britain, the Local Government Reform Act of 1980 forced local authorities to operate many services as if they were private companies without the capacity to generate a trading loss for a few years or to expand their business through national or international trade. Under this Act, local authorities could not use power to expand entrepreneurial skills to expand into markets other than those directly tied to the needs of the local authority. In other words, the local authorities were limited by Central government.
Hero [15] introduced a departure from the market-centered approach theory to local government reform. Hxe criticized efforts to evaluate local government solely in terms of the empirical distribution of concrete goods and services. People must be placed in the equation. Hero states that the value of ordinary individuals should be measured by the degree to which “outputs” of the system, in the form of security services and material support benefit them ([10]. p. 41). Unfortunately, Hero’s suggestions were not taken into consideration until in the 1990s in Great Britain and New Zealand. In the 1990s, under the leadership of Prime Minister Blair, the “Best Value” system was introduced as a means of ensuring effective and efficient service delivery. This system set targets for local authorities. Included in these targets is a strong customer service component.
In general, existing research on local government reform points to the influence of global economic forces. These forces limit the decision-making capacity of local government, particularly as it relates to economic development. This also impact on service delivery. Although the local authorities are constrained by global forces, the average taxpayers are still concerned about effective and efficient delivery of local services such as fire, sanitation, and provision of social services.
In Jamaica there is an increasing demand for efficient and effective service delivery. With this demand there is a tendency to argue for prioritizing some of these services as a means of achieving these goals. Walker and Davis [16] have conducted extensive research on impact on contracting government services in Great Britain. They argue that services that are easily defined, monitored, and for which appropriate measures for performance can be implemented are the best to be contracted. They also warned that the difficulty in contracting service the recipients (taxpayers) do not often get the best possible service but rather the best service according to the contract.
The promulgation of the various Acts governing local government inclusive of the Parish Council Acts of 1887, the Parochial Rate and Finance Act of 1990, the Kingston and St. Andrew Act of 1925 and Municipal Act of 2003, and most recently the Local Governance Act of 2016, among others, serve to further blur the distinction between the provision of and funding for services at local and central government levels. Increasingly, research on local government recognizes that the powers of national or central government have increased significantly since the 1960s. The central government have assumed more interest in maintaining order and authority at the local level as well as securing public revenues and preserving the interest of public officials in pursuit of the government overall goals relating to growth and development.
In Jamaica, as in other developing states, government spending on public service delivery at the local government level has seen a mercuric rise since the 1980s. Concomitant with this increase in spending, central government has increased its regulatory powers and the decision-making authority have become more centralized. This is evident by the passage of various acts of parliament to centralize funding mechanisms. This is with the aim to achieve economies of scale, eliminate duplication of services and increase service efficiency.
The emphasis on market driven forces to influence the provision of and funding for local government services also served to blur the lines between the responsibilities of local and central government to provide these services. However, Gurr and King [9] argue that “the provision of such public services as water supply, for protection and waste management cannot be left up to the market neither can it be the sole responsibility of one layer of government” Gurr and King ([9], p. 33). According to Gurr and King, “Whatever other interest is pursued by the national government, some minimum level of the public services must be provided if the local authority is to survive at all” Gurr and King, ([9], p. 35).
Ragoonath [17], in his essay, “Challenges for Local Government in the Caribbean” is of the view that Jamaica and other Small Island Developing States of the region is faced with issues of rebuilding credibility to a local government system. The rebuilding is necessary since for many years local government structures of the region has been “‘hijacked’ and even emasculated by central governments, and at the same time being an arena for corruption and mismanagement, all in the context of self-interest, political expediency and even party paramount.” ([17], p. 100). To remedy the situation Ragoonath calls for, reform of the legislative and the administrative structures in order that participation is enhanced, and citizens are empowered. He further argued that such reform must be because of consensus. Consensus will only come after consultation, and when trust is developed or inculcated. Moreover, the opinions of those at the bottom must be considered, alongside all other opinions [17].
In justifying the proposed geo-political parish status for Portmore, a newly elected government official representing Portmore stated that,
It is important to note that the existing Town and Country Planning Act (1957) and other legislative provisions make allowances for the Portmore Municipality and the other parishes to prepare its land use plan to address issues of urban blight, transportation, and settlement needs. Unfortunately, in this statement, the elected official failed to recognize these existing legislations and failed to mention the enabling legislative enactments and or policies and programmers that will be implemented for the Jamaican society to achieve the principles of sustainable development as measured by the Sustainable Development Goals (SDG) 11—safe, inclusive, and resilient cities and communities. Elsewhere in Small Island Developing States in the Caribbean and throughout the world, elected officials at the city level, policy makers, and city planners are actively working to create environmentally friendly, safe, and resilient communities, neighborhoods, and cities for their citizens without compromising the needs of the future generation.
The current administration in Jamaica must take care to adhere to the principles of the agreement under the New Urban Agenda which is the Framework for the implementation of SDG 11. By signing the New Urban Agenda, the government agreed to:
Support appropriate policies and capacities that enable subnational and local governments to register and expand their potential revenue base, while ensuring that poor households are not disproportionately affected.
Promote sound and transparent systems for financial transfers from national governments to subnational and local governments based on the latter’s needs, priorities, functions, mandates, and performance-based incentives, as appropriate, to provide them with adequate, timely and predictable resources and enhance their ability to raise revenue and manage expenditures.
Support the development of vertical and horizontal models of distribution of financial resources to decrease inequalities across subnational territories, within urban centres and between urban and rural areas, as well as to promote integrated and balanced territorial development.
Provide the transparency of data on spending and resource allocation as a tool for assessing progress towards equity and spatial integration.
Promote best practices to capture and share the increase in land and property value generated because of urban development processes, infrastructure projects and public investments. Measures such as gains-related fiscal policies could be put in place, as appropriate, to prevent its solely private capture, as well as land and real estate speculation.
Support the creation of robust legal and regulatory frameworks for sustainable national and municipal borrowing, based on sustainable debt management, supported by adequate revenues and capacities, by means of local creditworthiness as well as expanded sustainable municipal debt markets when appropriate.
To ensure that the government is not in breach of the New Urban Agenda and is able to achieve the SDGs, it is imperative that the necessary steps are taken to further enact the recommendations of the National Advisory Committee on Local Government Reform. The detailed Report prepared by the National Advisory Committee on Local Government Reform in 2009 for the government of Jamaica, recommend urgent need to reform the local government and governance structures to ensure sustainable development for Jamaica as a Small Island Developing States (SIDS).
In addition, the Report, among other things, proposed a legal framework that makes local government relevant to current realities and emerging trends regarding local governance and conducive to the achievement of good governance, sustainable development, empowerment of communities, and the active participation of citizens in the local governance process. In essence, the Report encourage decentralized local services provision, revenue collection and decision-making.
These recommendations in the Report are in keeping with several global think tanks approach to decentralization. Chief among them is the World Observatory on Subnational Government Finance and Investment. The World Observatory on Subnational Government Finance and Investment proposes the following definition: ‘decentralization consists of the transfer of powers, responsibilities and resources from central government to sub-national governments, defined as separated legal entities elected by universal suffrage and having some degree of autonomy’. This is in line with the view that the level of autonomy of the local government is critical to the decision about the proposed change in the geo-political designation of the Municipality of Portmore.
The proposal to change the geo-political designation of the Municipality of Portmore raises several questions about the economic profile of the area and the capacity to enjoy the benefits of urban agglomeration given its location attributes. The efficacy of the proposal was also considered against the background of the competitive advantage of the locality when compared to competing urban spaces, the political economy arrangements, and the legislative and policy environment to support this change. The economic viability of the proposition is at best questionable as the economic base of the municipality is limited and its capacity to generate linkages demand serious considerations. The change would most likely be accompanied by more intensive land use if this can be achieved without compromising the goals of sustainable development. Furthermore, many of these services are funded in part by several agencies but there is no clear picture of the total amount being allocated for these services. A reporting mechanism which emphasizes the services rather than the agency or Ministry will give a clearer picture of how much is being allocated for the particular service.
Another recommendation to ensure clearer understanding of the delivery of the public services is to develop clearer performance measures and a reporting format that is intrinsic to the whole process of the service being delivered. This includes, the management, planning, monitoring and evaluation of the service. Well defined and easily measured goals reported in a concise manner will help the decision makers and the general public has a better understanding of how the public purse is being spent towards the delivery of these services. These clear structures will help decision makers and the average citizens to determine the most appropriate urban agglomeration and the attendant government and governance structure. It is important for local government to concentrate on service delivery and get the necessary support from central government to support these service deliveries rather than an “upgrade” parish status without the requisite autonomy for expanding it economic base for improve service delivery.
Decision-makers are of the view that Portmore’s has the potential to attract the kind of economic activities in the quantities that will generate linkages and capitalize on economies, and which will provide job opportunities for its residents without acknowledging that the municipality’s current position is based on the relationship that exist within the network provided by the Kingston urban agglomeration. For Portmore to exist above or outside of the existing agglomeration, there is need for the appropriate mix of land uses and production linkages that will trap the benefits of knowledge sharing and the cross-fertilization of ideas, inputs, and outputs, that will expand returns to firms and by extension to the locality. Review of the draft land use plans for the Municipality of Portmore does not suggest that consideration is given to land use management that increase the return on investment to enable the provision of basic urban services.
It is also evident that central government in Jamaica continues to maintain autonomy over revenues and the sources of income and local government at the parish level are not empowered to make the necessary adjustments to manage its provision of public goods and services. As a result, the designation of parish may be accompanied by increased fiscal responsibility but not necessarily by the level of autonomy and financial independence of the local government that is needed for the area to grow at the same level or rate of the larger metropolitan area. More emphasis is needed to make local government relevant to current realities and emerging trends regarding local governance and conducive to the achievement of good governance, sustainable development, empowerment of communities, and the active participation of citizens in the local governance process rather than changing status of an urban areas which is the direct result of the principles of urban agglomeration.
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It plays a major role in enhancement of overall farm productivity, soil enrichment through litter fall, maintaining environmental services such as climate change mitigation (carbon sequestration), phytoremediation, watershed protection and biodiversity conservation. It is an effective and alternative management system to meet the target of increasing forest cover to 33 % as given by the national forest policy. Their scope and potential in any state including Chhattisgarh is tremendous. Farmers use generally N2-fixing trees like some from the Leguminosae family including Acacia spp., Dalbergia sissoo, etc., on their farmland for enhancing their field crops and generating incomes and employment. Therefore, rural people should make some strategy for the implementation of agroforestry model with suitable combination of trees and field crops, and this combination does not only generate income for the upliftment of socioeconomic value but also concerns the ecological and environmental stability on the sustained basis, i.e. emphasis should be more on scientific management of these models.",book:{id:"4757",slug:"precious-forests-precious-earth",title:"Precious Forests",fullTitle:"Precious Forests - Precious Earth"},signatures:"M.K. Jhariya, S.S. Bargali and Abhishek Raj",authors:[{id:"175133",title:"Dr.",name:"S. S.",middleName:null,surname:"Bargali",slug:"s.-s.-bargali",fullName:"S. S. 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The plant phenotype and ecology can be affected by the impact of the symbiotic microbes on the environment and competition for soil resources.",book:{id:"5877",slug:"plant-ecology-traditional-approaches-to-recent-trends",title:"Plant Ecology",fullTitle:"Plant Ecology - Traditional Approaches to Recent Trends"},signatures:"Ying-Ning Ho, Dony Chacko Mathew and Chieh-Chen Huang",authors:[{id:"198872",title:"Dr.",name:"Ying-Ning",middleName:null,surname:"Ho",slug:"ying-ning-ho",fullName:"Ying-Ning Ho"},{id:"199676",title:"Prof.",name:"Chieh-Chen",middleName:null,surname:"Huang",slug:"chieh-chen-huang",fullName:"Chieh-Chen Huang"},{id:"201133",title:"Dr.",name:"Dony",middleName:"Chacko",surname:"Mathew",slug:"dony-mathew",fullName:"Dony Mathew"}]},{id:"36984",doi:"10.5772/29590",title:"Individual-Based Models and Scaling Methods for Ecological Forestry: Implications of Tree Phenotypic Plasticity",slug:"individual-based-models-and-scaling-methods-for-ecological-forestry-implications-of-tree-phenotypic-",totalDownloads:2655,totalCrossrefCites:4,totalDimensionsCites:23,abstract:null,book:{id:"617",slug:"sustainable-forest-management-current-research",title:"Sustainable Forest Management",fullTitle:"Sustainable Forest Management - Current Research"},signatures:"Nikolay Strigul",authors:[{id:"78465",title:"Prof.",name:"Nikolay",middleName:null,surname:"Strigul",slug:"nikolay-strigul",fullName:"Nikolay Strigul"}]}],mostDownloadedChaptersLast30Days:[{id:"58228",title:"Pepper Crop under Climate Change: Grafting as an Environmental Friendly Strategy",slug:"pepper-crop-under-climate-change-grafting-as-an-environmental-friendly-strategy",totalDownloads:2132,totalCrossrefCites:9,totalDimensionsCites:17,abstract:"Pepper is an extremely important vegetable worldwide in socio-economic terms. However, persistent land use, monoculture, and intensified production processes have led to soil diseases. This, along with abiotic stress, and mainly salinity of soil and waters, water stress, and suboptimal temperatures, can lead to physiological disorders emerging in peppers, e.g., cracking and Blossom end rot, which induce plant senescence, and lower not only in yields, but also in product quality. Salinity and water shortage are the two main environmental problems that crops face in the Mediterranean Region. One way of overcoming stresses from an ecological or integrated crop management viewpoint is to use grafted plants as an adaptation strategy. Initially, grafting technology has expanded in Solanaceae and Cucurbitacea species to overcome biotic stress. Nowadays, grafts are being used as several approaches to cushion the impact of climate change on agricultural systems. Furthermore, grafts allow desirable varieties by organoleptic or productivity traits, but they are sensitive to abiotic stress and can be grown under abiotic stress. As far as we know, very few studies on grafted pepper plants under abiotic stress are available.",book:{id:"6171",slug:"climate-resilient-agriculture-strategies-and-perspectives",title:"Climate Resilient Agriculture",fullTitle:"Climate Resilient Agriculture - Strategies and Perspectives"},signatures:"Consuelo Penella and Angeles Calatayud",authors:[{id:"213492",title:"Dr.",name:"Angeles",middleName:null,surname:"Calatayud",slug:"angeles-calatayud",fullName:"Angeles Calatayud"},{id:"213498",title:"Dr.",name:"Consuelo",middleName:null,surname:"Penella",slug:"consuelo-penella",fullName:"Consuelo Penella"}]},{id:"65961",title:"The Disturbed Habitat and Its Effects on the Animal Population",slug:"the-disturbed-habitat-and-its-effects-on-the-animal-population",totalDownloads:1522,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"Changes in the “habitat” may interfere with the normal functioning of all biological systems. 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In this chapter, a summary is given for all the technologies that have been used for forest fire detection with explanation of what parameters these systems looking for to understand the fire behaviour.",book:{id:"6304",slug:"forest-fire",title:"Forest Fire",fullTitle:"Forest Fire"},signatures:"Ahmad AA Alkhatib",authors:[{id:"215875",title:"Dr.",name:"Ahmad",middleName:null,surname:"Alkhatib",slug:"ahmad-alkhatib",fullName:"Ahmad Alkhatib"}]}],onlineFirstChaptersFilter:{topicId:"34",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. 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His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Plant Physiology",value:13,count:1},{group:"subseries",caption:"Human Physiology",value:12,count:2},{group:"subseries",caption:"Cell Physiology",value:11,count:8}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2020",value:2020,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. 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At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"onlineFirst.detail",path:"/online-first/81497",hash:"",query:{},params:{id:"81497"},fullPath:"/online-first/81497",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()