\r\n\tFurthermore, during the preparation of high-quality dairy products, several physical, chemical, enzymatic, and microbial transformations take place. We will consciously focus on this interaction of different constituents of milk under different processing conditions for the development of the products.
",isbn:"978-1-83768-093-1",printIsbn:"978-1-83768-092-4",pdfIsbn:"978-1-83768-094-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"420e687768b56ca7b3238d77f63f1302",bookSignature:"Dr. Neelam Upadhyay",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12173.jpg",keywords:"Protein, Fat, Lactose, Carbohydrates, Milk Processing, Milk Products, Milk Constituents, Acid Coagulated, Enzyme Treated, Heat Treated, Dairy Products, Protocols of Manufacturing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 18th 2022",dateEndSecondStepPublish:"June 15th 2022",dateEndThirdStepPublish:"August 14th 2022",dateEndFourthStepPublish:"November 2nd 2022",dateEndFifthStepPublish:"January 1st 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"21 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Upadhyay has received many awards most notable being the Young Woman Scientist Award 2020 from the Agro-Environmental Development Society and the Best Poster Award 2021 from the National Conference on Moringa Food Conclave 2021. She is a dedicated researcher in food and dairy processing and has published many research articles and papers in both national and international journals and publications.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"269538",title:"Dr.",name:"Neelam",middleName:null,surname:"Upadhyay",slug:"neelam-upadhyay",fullName:"Neelam Upadhyay",profilePictureURL:"https://mts.intechopen.com/storage/users/269538/images/system/269538.jpg",biography:"BRIEF BIODATA\n1.\tName in full: Neelam Upadhyay \n2.\tDate & Place of Birth: 29th December, 1987 at Delhi\n3.\tField of specialization: Food Technology\n4.\tPresent Position/ Designation: Scientist- Senior Scale\n5.\tAddress:\t(a)\tOfficial:\tTel. No.:0184-2259258\n\t\t\t\tE-mail: \ticar.neelam@gmail.com; neelam.upadhyay@icar.gov.in \n\t\t\t\tAddress: \tLaboratory No. 146, Dairy Technology Division, ICAR- \n\t\t\t\t\t\tNational Dairy Research Institute, Karnal \n\t\t\t(b)\tResidential: Tel. No.: +91-9255772587\n\tAddress (Permanent): 41-D, MIG DDA Flats, Shivam Enclave, Delhi-110032\n6.\t(a) Academic career and (b) professional attainments\n(a) Examination\tClass/ Percentage\tYear of Passing\tSubjects Taken\tName of University / Board\nXth \t1st/83\n(415/500)\t2003\tMathematics, Social Science, Science, English, Hindi\tK.V., Mumbai (CBSE)\nXIIth\t1st/78.2 \n(391/500)\t2005\tPhysics, Mathematics, Chemistry, Biology, English\tK.V., Delhi (CBSE)\nB.A.Sc. (Hons.)\t1st/83.43 (2044/2450)\n(3rd position)\t2008\tFood Technology\tSRCASW, University of Delhi, Delhi\nM.Sc.\t1st/8.62\n(1st position)\t2010\tFood Science & Technology\tCCS Har. Agri. Uni., Hisar, Haryana\nTitle of Research:\tDevelopment of flavoured whey-soya milk beverage\nMajor Advisor:\tDr. R. S. Dabur (Professor and Head)\nPh.D.\t1st/8.0\n(1st position)\t2014\tDairy Chemistry\tNational Dairy Research Institute, Karnal, Haryana\nTitle of Research: \tDetection of vegetable oil and animal body fat adulteration in ghee using solvent fractionation technique\nMajor Advisor:\tDr. Darshan Lal (Principal Scientist and Ex-Head)\nDistinctions during Academics\nDegree\tDistinctions\nBachelor of Applied Science (Hons.)\ti.\tY.K. Kapoor Memorial Scholarship 2006 by All India Food Processor’s Association \nii.\t3rd position in university\niii.\tReceived highest attendance award\niv.\tReceived trophy for ‘Most Disciplined Student’ for the graduation period 2005-2008\nv.\tCertificate of Honor from Honb’le Mr. Justice K.G. Balakrishnan, Chief Justice of India\nMaster of Science\ti.\t1st position in discipline and 2nd position in college\nii.\tReceived recognition for academic excellence from Jawaharlal Nehru Memorial Fund; \niii.\tQualified GATE\niv.\t2nd in inter-college yoga competition\nv.\tParticipated in various events of All India Youth Festival organized at UAS, Bangalore.\nDoctor of Philosophy\ti.\tReceived Merit Certificate for Academic Excellence in PhD course work\nii.\tReceived Certificate of Appreciation for outstanding work in the field of Dairy Processing during PhD\niii.\tQualified ICAR’s National Eligibility Test in 2010; Qualified the ICAR’s All India Examination, ICAR-SRF (PGS_-2011-2012 for award of ICAR-SRF (PGS) with 2nd rank (both in first attempt) \niv.\tQualified Agricultural Research Service Examination-2013 conducted by Agricultural Scientist Recruitment Board against the single vacancy (for UR) in the discipline of Food Technology\nv.\tStage Management Secretary of student’s council 2010-11\nvi.\tLiterary secretary of Student’s Council 2011-12\nvii.\tCompleted certificate e-course on “Publishing a Journal Manuscript - the Groundwork” directed by Springer in 2013\nviii.\tHave successfully completed certificate e-course – “Peer Review Academy” directed by Springer in 2013\nix.\tReceived a certificate on accomplishment IRIS 4-2 Information Literacy Plagiarism Quiz (on-line) in 2013 developed by Distance Learning Council of Washington, USA \n (b) Position Held\tInstitution \tPeriod of Appointment\tNature of Appointment\nScientist (Food Technology)\tICAR- National Academy of Agricultural Research Management, Hyderabad\t3 months\n(1st January, 2015 till 31st March, 2015)\tPermanent\n(Received ‘A’ grade for FOCARS)\nScientist \n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t10th March, 2015 till 31st December, 2018\n(after availing 10 days of transfer period)\tPermanent\nScientist-Senior Scale\n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t1st January, 2019 till date\tPermanent\n\n7. Special attainments in Research\n(https://scholar.google.co.in/citations?hl=en&user=PRz0Tz4AAAAJ&view_op=list_works&sortby=pubdate)\nPublications\tNumbers\tRemarks \nResearch Articles\t35\n(24 Intl, 9 National, 2 others)\tTotal Impact: 72.302\n\nBook Chapters\t7\t5 APA/CRC Press; 1 InTech Open; \n1 National\nReview Articles\t2\tTotal Impact:8.327\nTechnical Articles\t7\tCompendium of trainings, seminars, etc\nInstitute publication\t1\t\nPopular Article\t12\t6 in English; 5 in hindi\nCitations \t1066\t(as per googlescholar)\nH-index/ i10-index\t15/ 17\t\n.\n.\nJournal\tNumber of publications\tImpact factor\nResearch Articles\t35\t72.302\nInternational\t24 (15 as either corresponding or first author)\t72.302\nNational\t9 (3 as first or corresponding author)\tNAAS score\nOthers\t2\t\nReview article (International)\t2\t8.327\nInternational\t2\t8.327\n.\n \n\n\n\nRESEARCH ARTICLES\nInternational Journals \n1.\tTiwari, S., Upadhyay, N.*, Singh, A. K. (2022). Stability assessment of emulsion of carotenoids extracted from carrot bio-waste in flaxseed oil and its application in food model system. Food Bioscience, 47, 101631. https://doi.org/10.1016/j.fbio.2022.101631.\n2.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Singh, A. K., & Borad, S. G. (2021). Buffalo milk protein concentrate 60: Effect of skim milk heat treatment on its reconstitutability and functionality. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 148, 111638. \n3.\tUttamrao, H. J., Meena, G. S., Khetra, Y., Upadhyay, N., Singh, A. K., Arora, S., & Borad, S. G. (2022). Homogenization and sodium hydrogen phosphate induced effect on physical and rheological properties of ultrafilterd concentrated milk. Journal of Food Science and Technology, 59(3), 956-967. \n4.\tTiwari, S., Upadhyay, N.*, Malhotra, R. (2021). Three way ANOVA for emulsion of carotenoids extracted in flaxseed oil from carrot bio-waste. Waste Management, 121, 67-76. \n5.\tRanvir, S., Sharma, R., Gandhi, K., Upadhyay, N., Mann, B. (2020). Assessment of proteolysis in ultra-high temperature milk using attenuated total reflectance–Fourier transform infrared spectroscopy. International Journal of Dairy Technology. 73(2): 366-375. doi: 10.1111/1471-0307.12683. \n6.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). High performance liquid chromatographic (HPLC) determination of available lysine in milk protein-maize composite extrudates and its stability during storage. Journal of the Indian Chemical Society, 97(11a), 2344-2350\n7.\tTiwari, S., Upadhyay, N.*, Singh, A. K., Meena, G. S., & Arora, S. (2019). Organic solvent-free extraction of carotenoids from carrot bio-waste and its physico-chemical properties. Journal of Food Science and Technology, 1-10. 10.1007/s13197-019-03920-5\n8.\tBaria, B., Upadhyay, N.*, Singh, A. K., & Malhotra, R. K. (2019). Optimization of ‘green’extraction of carotenoids from mango pulp using split plot design and its characterization. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 104, 186-194. \n9.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Borad, S. G., & Singh, A. K. (2019). Effect of change in pH, heat treatment and diafiltration on properties of medium protein buffalo milk protein concentrate. Journal of Food Science and Technology, 56(3), 1462-1472. \n10.\tUttamrao, H. J., Meena, G. S., Borad, S. G., Punjaram, S. A., Khetra, Y., Upadhyay, N., & Singh, A. K. (2019). Effect of disodium phosphate and homogenization on physico-chemical and rheological properties of buffalo skim milk based ultrafiltered retentate. Journal of food science and technology, 56(5), 2426-2435. \n11.\tMeena, G.S., Dewan, A., Upadhyay, N., Barapatre, R., Kumar, N., Singh, A.K., & Rana, J.S. (2019). Fuzzy Analysis of Sensory Attributes of Gluten Free Pasta Prepared From Brown Rice, Amaranth, Flaxseed Flours and Whey Protein Concentrates. Journal of Food Science and Nutrition Research, 2(1), 022-037. DOI: 10.26502/jfsnr.2642-1100006\n12.\tPatil, A. T., Meena, G. S., Upadhyay, N.*, Khetra, Y., Borad, S., & Singh, A. K. (2018). Production and characterization of milk protein concentrates 60 (MPC60) from buffalo milk. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 91, 368-374. https://doi.org/10.1016/j.lwt.2018.01.028 \n13.\tUpadhyay, N.*, Jaiswal, P., & Jha, S. N. (2018). Application of attenuated total reflectance Fourier Transform Infrared spectroscopy (ATR–FTIR) in MIR range coupled with chemometrics for detection of pig body fat in pure ghee (heat clarified milk fat). Journal of Molecular Structure, 1153, 275-281. \n14.\tUpadhyay, N.*, Kumar A., Goyal A. and Lal, D. (2017). Complete liquification time test coupled with solvent fractionation technique to detect adulteration of foreign fats in ghee (heat-clarified milk fat). International Journal of Dairy Technology. 70(1): 110-118. doi: 10.1111/1471-0307.12323. \n15.\tUpadhyay, N.*, Goyal A., Kumar A. and Lal, D. (2017). Detection of adulteration of caprine body fat and mixture of caprine body fat and groundnut oil in bovine and buffalo ghee using Differential Scanning Calorimetry. International Journal of Dairy Technology. 70(2): 297-303. May 2017.doi:10.1111/1471-0307.12336. \n16.\tKumar, A., Upadhyay, N.*, Ghai, D.L., Kumar, A. Gandhi, K. and Sharma, V. (2016). Effect of preparation and storage of khoa on physico-chemical properties of milk fat. International Journal of Dairy Technology. 69(2): 294-300. doi: 10.1111/1471-0307.12266. \n17.\tUpadhyay, N.*, Jaiswal, P. & Jha, S.N. (2016). Detection of goat body fat adulteration in pure ghee using ATR-FTIR spectroscopy coupled with chemometric strategy. Journal of Food Science and Technology. 53 (10): 3752-3760. doi:10.1007/s13197-016-2353-2 ISSN 0022-1155\n18.\tRathi, M., Upadhyay, N.*, Dabur, R.S. and Goyal A. (2015). Formulation and physic-chemical analysis of whey –soymilk dahi. Journal of Food Science and Technology. 52(2): 968-975. doi 10.1007/s13197-013-1074-z. ISSN: 0022-1155. \n19.\tKanthale, P., Kumar, A. Upadhyay, N.*, Lal, D., Rathod G. and Sharma, V. (2015). Qualitative test for the detection of extraneous Thiocyanate in Milk. Journal of Food Science and Technology. 52(3): 1698-1704. DOI: 10.1007/s13197-013-1174-9. ISSN: 0022-1155.\n20.\tGoyal, A., Sharma, V., Upadhyay, N., Singh, A.K., Arora, S. and Ghai, D.L. (2015). Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids. Journal of Food Science and Technology. 52(7):4256-4265. \n21.\tUpadhyay, N.*, Kumar, A., Rathod, G., Goyal, A. and Lal, D. (2015). Development of a method employing reversed-phase thin-layer chromatography for establishing milk fat purity with respect to adulteration with vegetable oils. International Journal of Dairy Technology. 68(2): 207-217. doi. 10.1111/1471-0307.12178. \n22.\tGoyal, A., Siddiqui, S. Upadhyay, N., Soni, J. (2014). Effects of ultraviolet irradiation, pulsed electric field, hot water and ethanol vapours treatment on functional properties of mung bean sprouts. Journal of Food Science and Technology. 51(4): 708-714. doi 10.1007/s13197-011-0538-2. Publisher Springer. ISSN (electronic version): 0975-8402. \n23.\tKundu, H., Grewal, R.B., Goyal, A., Upadhyay, N.*, and Prakash S. (2014). Effect of incorporation of pumpkin (Cucurbita moshchata) powder and guar gum on the rheological properties of wheat flour. Journal of Food Science and Technology. 51(10):2600-2607. DOI: 10.1007/s13197-012-0777-x. ISSN: 0022-1155. \n24.\tUpadhyay, N.*, Kumar, A., Goyal, A. and Lal, D. (2014). A planar chromatographic method to detect adulteration of vegetable oils in ghee. JPC-Journal of Planar Chromatography-Modern TLC. 27 (6): 431-437. DOI: 10.1556/JPC.27.2014.6.5 \nNational Journals\n1.\tPonbhagavathi, T. R., Singh, A. K., Raju, P. N., Upadhyay, N. (2021). Textural and Sensory Characteristics of Milk Protein-Maize Flour-based Extrudates. Journal of Agricultural Engineering, 58(2), 124-136. 10.52151/jae2021581.1740\n2.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). Effect of Rennet Casein and Whey Protein Concentrate on Extrusion Behavior of Maize Flour. Current Journal of Applied Science and Technology. 39(33), 16-27, Article no.CJAST.57830.\n3.\tUpadhyay, N.*, Kumar, A., Lal, D., Kant, R., & Goyal, A. (2018). Detection of groundnut oil and goat body fat adulteration in ghee using principal component analysis on fatty acid profile. Indian Journal of Dairy Science. 71(5):464-472. \n4.\tUpadhyay, N.*, Kumar, A., Gandhi, K., Goyal, A. and Lal, D. (2014). Standardization of solvent fractionation technique for detection of adulteration in ghee by enriching animal body fat and vegetable oil in different fractions. Indian Journal of Dairy Science. 67 (4):323-327.\n5.\tGandhi. K., Upadhyay, N., Aghav, A.D., Sharma, V., and Lal, D. (2014). Detection of adulteration of ghee (clarified milk fat) with palmolein and sheep body fat using Reichert-Meissl (RM) value coupled with solvent fractionation technique. Indian Journal of Dairy Science. 67(5): 387-393. Received Second Best Paper Award during 44th Dairy Industry Conference organized by ICAR-NDRI, Karnal and Indian Dairy Association from 18-20, February 2016.\n6.\tAghav, A.D., Gandhi, K., Upadhyay, N., Kumar, A. and Lal, D. (2014). A study on the physico-chemical changes occurring in the milk fat during preparation of Paneer. Indian Journal of Dairy Science. 67 (5): 398-404.\n7.\tKumar, A., Upadhyay, N., Gandhi, K., Lal, D. and Sharma, V. (2013). Detection of soybean oil and buffalo depot fat in ghee using Normal-Phase Thin Layer Chromatography. Indian Journal of Dairy Science. 66(4): 294-99. ISSN: 0019-5146.\n8.\tKumar, A., Upadhyay, N., Gandhi, K., Kumar, A., Lal, D. and Sharma, V. (2013). Reverse-Phase Thin Layer Chromatography of Unsaponifiable Matter of ghee for detecting adulteration with soybean oil and buffalo depot fat. Indian Journal of Dairy Science. 66(6): 496-501. ISSN: 0019-5146.\n9.\tUpadhyay, N.*, Dabur R.S. and Rathi, M. (2011). Development and Shelf life Study of Flavoured Whey-soya milk beverage. Indian Journal of Dairy Science. 64(2): 92-101. ISSN: 0019-5146.\nOther Journals\n1.\tDewan, A., Meena, G.S., Upadhyay, N., Barapatre, R. Singh, A.K., Rana, J.S. (2017). Formulation of non-Gluten Pasta from the Optimized levels of Dairy and Non-Dairy ingredients. Madridge Journal of Food Technology. 2(2): 92–98. \n2.\tGalmessa, U., Prasad, S., Kumaresan, A., Oberoi, P. S., Baithalu, R. K., Upadhyay, N., and Dang, A. K. (2015). Modulation of Milk Fatty acid profile milk yield and composition through supplementation of omega-3 fatty acid in transition cow’s diet. Journal of Science and Sustainable Development. 3(1): 25-38. ISSN: 2070-1748\nREVIEW ARTICLES\n1.\tUpadhyay, N.*, Goyal, A. Kumar, A., Lal, D. and Singh, D. (2014). Preservation of milk and milk products for analytical purposes: A review. Food Reviews International. 30(3):203-224. DOI 10.1080/87559129.2014.913292. ISSN: 1525-6103\n2.\tGoyal, A., Sharma, V., Upadhyay, N., Gill, S. and Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology. 51(9): 1633-1653. DOI 10.1007/s13197-013-1247-9. ISSN: 0975-8402. \nBOOK CHAPTERS\n1.\tKumari, L., Sharma, M., & Upadhyay, N. (2021). Three-Dimensional Printing of Food Products: Printing Techniques, Novel Applications, and Printable Food Materials. Handbook of Research on Food Processing and Preservation Technologies: Volume 3: Computer-Aided Food Processing and Quality Evaluation Techniques, 55. Boca Raton, CRC Press\n2.\tUpadhyay, N.*, Harshitha, C. G., Pathak, N. K., & Sharma, R. (2021). Fourier Transform Infrared (FTIR) Spectroscopy with Chemometrics: Evaluation of Food Quality and Safety. Handbook of Research on Food Processing and Preservation Technologies: Volume 5: Emerging Techniques for Food Processing, Quality, and Safety Assurance, 271.\n3.\tNagarajappa, V., Upadhyay, N., Chawla, R., Mishra, S.K., & Nath, S. (2019). Functional Properties of Milk Proteins. In: Engineering Practices for milk products- Dairyceuticals, Novel Technologies, and Quality (pp 3-26). Apple Academic Press.\n4.\tUpadhyay, N., Kumar, M. C. T., Sharma, H., Borad, S., & Singh, A. K. (2019). Pulse Electric Field Processing of Milk and Milk Products. In: Non-thermal Processing of Foods (pp.129-144). Boca Raton, CRC Press\n5.\tUpadhyay, N., Nagaraj, V., & Singh, A. K. (2019). Advances in Fractionation of Milk Lipids: Analysis and Applications of fractions In: Recent Technologies in Dairy Science (pp. 325-344). Today and Tomorrow’s Printers and Publishers.\n6.\tNagaraj, V., Upadhyay, N.*, Nath, B. S., & Singh, A. K. (2018). Advances in Fractionation and Analysis of Milk Carbohydrates. In Technological Approaches for Novel Applications in Dairy Processing (pp. 127-147). IntechOpen. http://dx.doi.org/10.5772/intechopen.76312\n7.\tUpadhyay, N.*, Veena, N., Borad, S., & Singh, A. K. (2017). Application of Natural Antioxidants in Dairy Foods. In Natural Antioxidants (pp. 281-318). London: Apple Academic Press.\nINSTITUTE PUBLICATION\n1.\tDr. T. K. Datta, Dr. Meena Malik and Dr. Neelam Upadhyay (2017). Foundation Programme for Freshers at ICAR-NDRI 2017.\nPOPULAR AND LEAD ARTICLES\n1.\tPatil, A. T., Meena, G. S., Upadhyay, N., & Singh, A.K. (2017). Milk protein concentrates- Their Applications. Indian Dairyman, 69(9), 44-48.\n2.\tUpadhyay, N.* and R.K. Malik (2015). Nutritive Value of Milk. In: In Touch, Heinz Nutrition Foundation of India. Volume 17, Number 2&3, 2-11. (Lead Article). \n3.\tGoyal, A., Sharma, V., Upadhyay, N., Sihag, M. and Kaushik, R. (2013). High Pressure Processing and its impact on milk proteins: A Review. Research and Reviews: Journal of Dairy Science and Technology. 2 (1): 1-9. ISSN: 2319-3409.\n4.\tKumar, A., Upadhyay, N., and Naagar, S. (2012). Allergenicity of Milk Proteins, and its Management. Indian Food Industry. 31 (5&6): 45-50. ISSN: 0972-2610.\n5.\tGoyal, A. and Upadhyay, N. (2012). Nuclear Magnetic Resonance Spectroscopy in Dairy Science. Indian Food Industry. 31(1): 39-45. ISSN: 0972-2610.\n6.\tUpadhyay, N.*, Goyal, A. and Rathod, G. (2011). Microwave Spectroscopy and its applications in online processing. Indian Food Industry. 30(5&6): 63-73. ISSN: 0972-2610.\n7.\tउपाध्याय, नी*. (२०१८) भारत में कुपोषण: स्थिति और इससे निपटने के लिए रणनीतियाँ. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. २४-२९. \n8.\tउपाध्याय, नी.*, सिंह, आ.कु., गांगुली, स., सबिखी, ल. (२०१८) खाध्य और डेयरी क्षेत्र मे महिला उद्यमिता: कारण, समस्याए एवम उपलब्ध मंच. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. ६४-६९.\n9.\tउपाध्याय, नी*. (२०१९) ek¡ dk nw/k % f'k'kqvksa ds ekufld] 'kkjhfjd ,oa lkekftd mRFkku gsrq ve`r. दुग्ध—गंगा (नवाँ अंक). अकटूबर –मार्च १०२-१०४.\n10.\tउपाध्याय, नी*, fç;k ;koys (२०१९) [kk| inkFkksaZ esa —f=e ds cnys çk—frd jax o.kZd ds mi;ksx dh vko';drk दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १०२-१०५.\n11.\tuhye mikè;k;, fuys'k dqekj ikBd (२०१९) d`f\"k] [kk| ,oa Ms;jh m|ksx ds Hkfo\"; eas lkSj ÅtkZ dk egRo दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १२६-१३०. \n12.\tवैज्ञानिक और तकनीकी विषय के मूल हिंदी लेख जोकि गेहूँ एवम् जौ स्वर्णिमा में प्रकाशित हुए: उपाध्याय, नी*, राकेश कुमार (2020) महिला उद्यमिता के माध्यम से महिला सशक्तिकरण. गेहूँ एवम् जौ स्वर्णिमा (बारहवााँ अंक), पृष्ठ सं. 55-58; भाकृअनुप- भारतीय गेहूँ एवम् जौ अनुसंधान संस्थान, करनाल- १३२००१ द्वारा प्रकाशित\n\n8. Concepts/Processes/Products/Technologies/Patents/Others\n(i)\tConcepts \nCurrently, I am working on the integrated approach of application of green technology for the development of functional foods by utilizing under-utilized/ indigenous fruits and vegetables and/ or bio-waste. In the research projects, I am also keenly working on food chemistry and instrumental food analysis and applications of technologies/ products in dairy and non-dairy products. \nBesides this, I am working on development of functional food for addressing menopausal symptoms in osteopenic mice model. \n(ii)\tProducts/ Technologies ready for commercialization- 5\n1. Production of Milk Protein Concentrate 60 (MPC60), a high protein low lactose powder from buffalo milk (Co-Inventor)\n2. Technology for omega-3 rich mixed fat table spread (Inventor)\n3. Lipid and water soluble yellow natural colouring ingredient from bio-waste (Inventor)\n4. Technology for preparation of encapsulated flaxseed oil for its applications in foods (Inventor)\n5. Production of buffalo milk based Milk Protein Concentrate 60 (MPC60) powder with improved solubility (Co-Inventor)\n(iii) Expertise on\n1.Gas Liquid Chromatography\t5.Thin Layer Chromatography\n2.Fourier Transform Infra-red Spectroscopy\t6. Spectrophotometry\n3.Differential Scanning Calorimetry\t7.Chemical analysis including titration, distillation, etc.\n4.High Pressure Liquid Chromatography\t\n\n\n9. List of completed, on-going and submitted projects\nTitle of Project\tDuration\tRole\tFunding\tStatus\tRemarks\nEffect of storage on Baudouin test, sesamin test and RP-TLC test to detect adulteration of vanaspati and vegetable oils in ghee\t2015-2017\tCo-PI\tICAR-NDRI\n\tCompleted\tTwo research articles on RP-TLC\nPreparation and Characterization of Micro/nano delivery systems for “green” carotenoids\t2016-2019\tPI\t-Do-\t\t3 research articles+ 3 products/ technologies\nTechnology Development for the Production of Milk Protein Concentrate (MPC60) From Buffalo Milk\t2016-2019\tCo-PI\t-Do-\t\t4 research articles+ 2 products/ technologies\nTechnology of Goat Milk based Functional Beverage\t2017-2020\tCo-PI\t-Do-\t\tOne oral presentation\nTechnology for Moringa oleifera enriched cheese spread\t2020-2023\tPI\t-Do-\tOn-going\tCharacterization and incorporation of M. oleifera- pods in cheese spread is complete; shelf life study and animal trial is in progress\nDevelopment of flaxseed-rich probiotic dairy foods to address menopause symptoms\t2020-2023\tCo-PI\tDST\t\tDeveloped method -estimation of phytoestrogen; validation -in progress\nNutritional and therapeutic validation of chhachh and ghee prepared from indigenous cows by traditional method\tThree years (proposed)\tPI\tSEED Division, DST\tSubmitted \n \t\nCharacterization of Moringa oleifera leaves for functional bioactives and its application in table spread as model food system\tThree years (proposed)\tPI\tSYST, DST\t\t\nOther research work: \nDetection of adulteration of goat body fat and pig body fat in ghee using ATR-FTIR coupled with chemometrics; carried out during Professional Attachment Training at ICAR-CIPHET, Ludhiana\n\n\n\n10. Awards & honours \nName of Award\tYear\tAwarding Agency\nBest Paper Award\t2022\tGSAT (Gender Advancement for Transforming Institutions Self-Assessment Team), NDRI\nBest Poster Award\t2021\tNational Conference on Moringa Food Conclave-2021\nYoung Woman Scientist Award\t2020\tAgro Environmental Development Society during International Web-conference \nSecond Best Poster Award\t2020\tIndian Dairy Association\nCommendation certificate for Institute’s Magazine in which I am co-Editor\t2020\tTown Official Language Implementation Committee, Karnal\nLetter of Appreciation to editorial board of Institute’s magazine for receiving ICAR’s Second Prize and Trophy under Ganesh Shankar Vidyarthi Hindi Patrika Puraskar (2018-19)\t2020\tICAR- National Dairy Research Institute, Karnal\nAssociate Fellowship\t2019\tNational Academy of Dairy Science India\nFirst Prize in E-poster \t2018\tIndian Dairy Association\nOne Best oral Presentation\t2018\tHome Science Association of India\nBest Oral Presentation to my Master’s student\t2018\tICMR- National Institute of Nutrition\nBest Poster Award\t2016\tIndian Dairy Association\nSecond Best Paper Award\t2016\tIndian Dairy Association\nICAR-SRF (PGS) with 2nd rank\t2011-12\tICAR\nGATE (Engg Sciences: Food Tech; Thermodynamics)\t2010\tMHRD, GoI\nInstitution level awards\nThird prize in poster presentation \t2021\tICAR- National Dairy Research Institute, Karnal\nInstitute’s Rajbhasha Gaurav Certificate\t2020\t\nFirst prize in Scientific and Technical writing\t2019\t\nConsolation prize in Scientific and Technical writing \t2020, 2019 \t\nFirst prize in Poster Presentation- 2020, 2018, 2017\t\t\nThird prize in poster presentation\t2019\t\nFirst Prize in hindi extempore\t2017\t\nThird, first and second prize in hindi essay writing in consecutive years – 2020, 2019, 2018\t\t\n\n\n11. Teaching Assignments \n(a) Teaching: Actively involved either as course in-charge or associate \nClass\tB.Tech (DT)\tMSc/ MTech\n(FT) (till 2021)\tM.Tech (DT)\tPhD (DT/ DC/ FSQA)\nNo. of courses\t1-2\t2-3\t0-1\t2-3\nDT- Dairy Technology, DC- Dairy Chemistry, FT- Food Technology, FSQA- Food Safety Quality Assurance\n(b) Student’s guided\nDegree\tMajor Advisor \tCo-Advisory\tStatus/ Remarks\nM. Tech (DT)\t8\t2\tCompleted\n\t1\t0\tOn going\nM. Tech/ M Sc (FT/ FSN)\t2\t1\tCompleted\nM. Tech (DC)\t0\t3\tCompleted\nM. Tech (DM)\t0\t1\tCompleted\nPhD (DT)\t2 \t0\tOngoing \n\t0\t2\tCompleted\nPhD (DC)\t0\t1 \tCompleted\n\t\t1\tOn going\ni.\tThree students under my guidance as major advisor and one student as co-advisory member nominated for Best thesis award; \nii.\tOne represented NDRI at zonal-level student research convention ANVESHAN-2018\n\n12. Lectures/ member/convener of committees: \ni.\tLectures: \na.\tEntrepreneurship Development Programme (EDP) (conducted by SINED-TBI/BPD unit, ICAR-NDRI) and Online Training of Master Trainers on Fat and Oilseed processing conducted by SINED-TBI/BPD unit (ICAR-CIPHET); \nb.\tStudent’s Counselling session at SRCASW, University of Delhi, \nc.\tWorkshop conducted at DAV college, Karnal, etc\nd.\tDelivered talks at various villages on the importance of mother’s milk, nutrition in first 1000 days of an infant’s life, nutri-thali, etc\nii.\tTraining Organized: \na.\tTwenty one days Training at Centre for Advanced Faculty Training (DT Division) on ‘R & D strategies and interventions for effective agribusiness and entrepreneurship development in dairy and food sector’; \nb.\tone/two months or shorter duration trainings for students and others under BPD unit and KVK, NDRI, Karnal\nc.\tFive days training on the aspects of dairy processing to the farmers of Karnal district. \niii.\tGeneral Secretary, Staff Club, NDRI, Karnal\niv.\tMember: Student Empowerment Unit, Conferences organized from 2015 till 2018, convocation, credit seminar evaluation committees; Mera Gaon Mera Gaurav program, Farmer’s First Door programme, Swatchh Bharat Abhiyan, coordinator and mentor of different groups for organizing Foundation Program-2017, 2018, Nodal officer of Poshan Maah-2020 etc\nv.\tConvener/ Rapporteur of sessions: Conference, Dr. K. K. Iya Memorial oration; International conference of Proteomics Society of India\nvi.\tOther responsibilities: Management Representative of QMS-IS/ISO 9001:2008 and HACCP- IS 15000:2013 of Experimental Dairy (essential part of institute) until Jan 2019; one of the editors of Institute hindi magazine Dudgh Ganga which also received coveted award from ICAR (until 2019).\nvii.\tResource Generation on account of consultancy provided in field of dairy processing and by conducting sponsored trainings \nMore than ₹ 2 50 000/- (Two lakhs fifty thousand only)\nviii.\tBesides research, teaching and extension activities, I am also involved in promotion of Hindi language and have won several prizes during competitions (like extempore, essay, e-mail writing) organized by Official Language Units.\nix.\tLifetime Member of three scientific bodies: Indian Dairy Association- RE/NZ/LM/10852/HR; Association of Food Scientists & Technologists (INDIA)- AFST/LM/9-2018/KRN/2444; Lifetime member of Home Science Association of India; Membership number: HSAI-2017-HR-127-LF\nx.\tReviewed research papers of Journal of Ayurveda and Integrative Medicine (Elsevier), LWT, International Journal of Food Properties, Indian Journal of Dairy Science, Indian Journal of Natural Products and Resources, United Scientific Group, etc. \n\n\n\n\n\n\n\n\nDated: 12-04-2022\t \nNeelam Upadhyay",institutionString:"National Dairy Research Institute",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Dairy Research Institute",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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\n
1. Introduction
\n
The prevalence of hepatitis C virus (HCV) antibodies in Croatia is low in the general population (reported <1%). HCV seroprevalence in the Croatian adult general population is similar to the prevalence rates of many European countries (for example Spain, France, Belgium, Poland, and Bulgaria) [1–5]. In comparison with other European countries, there have also been changes in the HCV epidemiology in Croatia over the past few decades. According to the published data, the estimated number of HCV-infected patients in Croatia is around 39,000, although the experts’ opinion is that the real numbers are significantly smaller [6, 7]. There was no significant difference in the HCV seropositivity between males and females in the Croatian population, with the highest prevalence in the 30–39 age group (1.7%) [8]. Routine HCV screening of blood products was introduced in Croatia in 1992.
\n
The prevalence of HCV infection in some population groups in Croatia is shown in Table 1 [9–21]. Patients requiring multiple transfusions have a high prevalence of HCV infection, but with the implementation of mandatory anti-HCV and HCV RNA screening of blood/blood donations, the risk of transfusion-associated hepatitis C has virtually been eliminated. [22]. HCV seroprevalence in the Croatian pregnant women is comparable to data reported in Switzerland and Spain [23, 24]. In this population, injecting drug users (IDU), history of blood products transfusion before 1992 and hospitalization with surgical procedures were identified as most common risk factors [25]. Since blood donors represent a strictly controlled group, it is expected that the HCV prevalence is lower than in the general population [26]. There are no published data on the HCV prevalence in the Croatian healthcare workers who have sustained contaminated needle stick injuries (occupationally exposed groups) [27].
Prevalence of HCV infection in Croatia in different population groups.
\n
Prevalence of HCV genotypes in Croatia varies by different population groups and regions.The prevalence of genotypes in Croatian population is shown in Table 2. In the general population, genotype 1 is the most widely distributed, while genotype 3 is predominant among IDUs. The most commonly detected subtype is 1b and it is predominant in hemodialysis patients. In prison population, genotype 1 and 3 are equally distributed and similar genotype distribution is found in groups with high-risk sexual behavior [28–31]. Similar pattern of genotype distribution is found in other European countries, where genotypes 1 and 3 also account for the majority of HCV infections with the most frequent subtype 1b [32]. The prevalence of genotype 4 is rising in Europe (in countries such as France, Germany, Greece, Italy, Poland, Portugal, Spain, Sweden, and Switzerland) due to immigration in these areas [33].
\n
\n
\n
\n\n
\n
HCV genotype
\n
Prevalence
\n
\n\n\n
\n
Genotype 1
\n
60.4–79.8%
\n
\n
\n
Genotype 1, subtype 1b
\n
41.6%
\n
\n
\n
Genotype 3
\n
12.9–47.9%
\n
\n
\n
Genotype 3 (IDUs)
\n
60.5–83.9%
\n
\n\n
Table 2.
Prevalence of HCV genotypes in Croatia.
\n
\n
\n
2. Indications for treatment in Europe and Croatia
\n
Following new trends in the management of viral hepatitis, an expert panel held the first Croatian Consensus Conferences on Viral Hepatitis in 2005, and later in 2009 and 2013. With the development of new classes of direct-acting antiviral agents (DAAs) and interferon-free regimens, the landscape of HCV treatment has significantly changed. The European Association for the Study of the Liver (EASL) published its recommendations in 2015, with the latest update in September 2016, and the World Health Organization in May 2016 adopted the first-ever Global Health Sector Strategy on viral hepatitis with the longer-term aim to reduce new viral hepatitis infection by 90% by 2030. Management of HCV infection in Croatia is in accordance with the EASL Guidelines published in 2015, Croatian Guidelines (published by the Croatian Referral Centre for the Diagnostics and Treatment of Viral Hepatitis at University Hospital for Infectious diseases ‘Dr. Fran Mihaljević’ and updated in April 2016), and the recommendations of the Croatian Health Insurance Fund (HZZO) which covers the costs of treatment for all patients in accordance with the recommended guidelines. These recommendations are based on currently licensed drugs and updated regularly, following approval of new drug regimens.
\n
There are some differences comparing EASL and Croatian Guidelines, which are listed as following. According to EASL Guidelines from 2015 and Croatian Guidelines, treatment should be prioritized (considered without delay) in patients with significant fibrosis or cirrhosis (METAVIR Score F3 or F4), including decompensated (Child-Pugh B or C) cirrhosis, in patients with clinically significant extra-hepatic manifestations, in patients with HCV recurrence after liver transplantation, and in HBV/HIV-coinfected patients (not in latest EASL Guidelines in 2016). Compared with EASL Guidelines, in Croatia, treatment is also prioritized in patients before or after solid organ transplantation and justified for individuals at risk of transmitting HCV (IDU, men who have sex with men with high-risk sexual practices, women of child bearing age who wish to get pregnant, hemodialysis patients, and incarcerated patients); in EASL Guidelines, they are in prioritized category. In Croatia, treatment is justified in patients with moderate cirrhosis (METAVIR F2) and in patients with long disease duration (>20 years), regardless of fibrosis (not in EASL recommendations; indication of moderate cirrhosis was in previous EASL recommendations from 2015.). Treatment can be deferred in Croatian patients (not in EASL Guidelines) with no or mild disease (METAVIR Score F0 and F1) and in patients with none of the clinically significant extra-hepatic manifestations. The latest EASL recommendations from 2016 (not in Croatian Guidelines) say that treatment should be considered without delay in patients with significant fibrosis or cirrhosis (METAVIR score F2, F3, or F4), including decompensated (Child-Pugh B or C) cirrhosis, in patients with clinically significant extra-hepatic manifestations (e.g., symptomatic vasculitis associated with HCV-related mixed cryoglobulinemia, HCV immune complex-related nephropathy, and non-Hodgkin B cell lymphoma), in patients with HCV recurrence after liver transplantation, and in individuals at risk of transmitting HCV (active injection drug users, men who have sex with men with high-risk sexual practices, women of child-bearing age who wish to get pregnant, hemodialysis patients, and incarcerated individuals). In all recommendations, treatment is not recommended in patients with limited life expectancy due to non-liver-related comorbidities [34–38].
\n
\n
\n
3. Therapeutic protocol
\n
The goal of therapy is to cure HCV infection to prevent hepatic cirrhosis, decompensation of cirrhosis, hepatocellular carcinoma, severe extrahepatic manifestations, and death. The endpoint of therapy is undetectable HCV RNA in blood by a sensitive assay 12 weeks (SVR12—sustained virologic response) and/or 24 weeks (SVR24) after the end of treatment [37].
\n
For decision-making related to therapies/drug selection, various factors are important: age, duration of infection, stage of fibrosis/cirrhosis, response to previous antiviral therapy, extrahepatic manifestations, comorbidities (HBV/HIV coinfection, autoimmune disease), concomitant therapy, genotype (1, 2, 3, 4), subgenotype (1a, 1b), HCV RNA viral load, presence of mutations that confer resistance to certain antiviral drugs and IL-28B genotype (CC, CT, TT) if interferon-based therapies are being considered.
\n
With the introduction of the first two protease inhibitors (PI) in 2011, the new era of HCV therapy began. Boceprevir and telaprevir as the first-generation of oral direct-acting antiviral agents (DAAs) became available in Croatia in 2013, for the treatment of genotype 1 HCV patients who failed PegIFN and ribavirin therapy.
\n
Croatia is a member of the European Union and all drugs registered by European Medicines Agency are also approved for use in Croatia. Available drugs for the treatment of HCV in Croatia (with costs covered directly by Croatian Health Insurance Fund—HZZO) in 2016 are: PegIFN, ribavirin, simeprevir, sofosbuvir, combination of ombitasvir + ritonavir-boosted paritaprevir ± dasabuvir, and sofosbuvir + ledipasvir. In the European Union, there are some drugs that are not yet available in Croatia: velpatasvir, daclatasvir, grazoprevir, and elbatasvir.
\n
Croatian Guidelines for the treatment are based on EASL and AASLD recommendations, but are somewhat more restrictive. For the treatment of naive patients with genotype 1 in 2016, it was still recommended to use the combination therapy with PegIFN and ribavirin (24–48 weeks) for patients with mild fibrosis and favorable predictors of response. For those patients with unfavorable predictors, if they achieve rapid virologic response (RVR), standard PegIFN and ribavirin combination is also recommended, otherwise a protease inhibitor (PI)—simeprevir or sofosbuvir should be added. In those with advanced fibrosis (F3), simeprevir or sofosbuvir should be added to PegIFN + ribavirin. Patients with significant (F4) fibrosis, who have contraindications to IFN therapy, presence of extrahepatic manifestations, HIV-coinfection or in transplanted patients, IFN-free regimens should be used for 12 weeks (ombitasvir, ritonavir-boosted paritaprevir, dasabuvir ± ribavirin; sofosbuvir and ledipasvir ± ribavirin; sofosbuvir and simeprevir ± ribavirin). For patients with decompensated cirrhosis, the combination of sofosbuvir and ledipasvir with or without ribavirin should be used, which is the same as recommended by the EASL and AASLD Guidelines. The main difference to EASL Guidelines is that, according to EASL, naive patients with or without compensated cirrhosis are treated with fixed-dose combination of sofosbuvir and ledipasvir without ribavirin.
\n
For the treatment of experienced patients with genotype 1, triple combination of PegIFN, ribavirin, and a PI (simeprevir or sofosbuvir) is recommended in those with previous relapse or partial response (F1-F3 fibrosis). For nonresponders to PegIFN-ribavirin treatment (regardless of fibrosis) and for patients with F4 fibrosis (regardless of type of response), as well as for patients with TT IL-28B genotype, contraindications to IFN therapy, presence of extrahepatic manifestations, HIV-coinfection and transplanted patients, IFN-free regimens are offered (previously mentioned for treatment of naive patients). For patients with decompensated cirrhosis, the only treatment option currently available is the combination of sofosbuvir and ledipasvir with ribavirin for 12 weeks or without ribavirin for 24 weeks. This is also the only available option for patients previously treated with the triple combination of PegIFN + ribavirin + first-generation PIs (boceprevir or telaprevir) (in Croatia, there are only a few patients that have not responded to treatment with new-generation DAAs, as they have recently become available). According to EASL, experienced, DAA-naive patients with genotype 1b with or without compensated cirrhosis should be treated with fixed-dose combination of sofosbuvir and ledipasvir without ribavirin, and with ribavirin in those patients with genotype 1a. In EASL Guidelines, for the treatment of naive and experienced patients with genotype 1, there are two more options (not available in Croatia): fixed-dose combination of sofosbuvir and velpatasvir without ribavirin, ritonavir-boosted paritaprevir, ombitasvir and dasabuvir with or without ribavirin, grazoprevir and elbasvir with or without ribavirin, and sofosbuvir and daclatasvir with or without ribavirin.
\n
For the treatment of patients with genotype 4, the same recommendations as for genotype 1 apply, with the exception of fixed combination of ombitasvir, paritaprevir, and ritonavir, which is used without dasabuvir. In patients with cirrhosis, duration of treatment is 24 weeks. In EASL Guidelines, for the treatment of these patients, there are few more options available: sofosbuvir and velpatasvir without ribavirin, grazoprevir and elbasvir with or without ribavirin, and sofosbuvir and daclatasvir with or without ribavirin.
\n
For the treatment of naive patients with genotype 2, with F1-F3 fibrosis, the use of standard combination treatment with PegIFN and ribavirin for 24 weeks is still recommended. Naive patients with F4 fibrosis, nonresponders (regardless of fibrosis), patients with contraindications to IFN therapy, with presence of extrahepatic manifestations, HIV-coinfection and transplanted patients are treated with combination of sofosbuvir and ribavirin (12 weeks without cirrhosis and 16–20 weeks with cirrhosis). In EASL recommendations, for the treatment of these patients there are two options: sofosbuvir and velpatasvir without ribavirin and sofosbuvir and daclatasvir without ribavirin.
\n
For the treatment of naive patients with genotype 3, with F1-F3 fibrosis, it is still recommended to use PegIFN and ribavirin for 24 weeks. Naive patients with F4 fibrosis and nonresponders to PegIFN + ribavirin therapy (regardless of fibrosis) are treated with combination of sofosbuvir, PegIFN, and ribavirin for 12 weeks. Patients with F1-F3 fibrosis and with contraindication to IFN therapy are treated with combination of sofosbuvir and ribavirin for 24 weeks. Those patients with F4 fibrosis and with contraindication to IFN therapy are treated with combination of sofosbuvir and daclatasvir for 12 weeks or combination of sofosbuvir, ledipasvir, and ribavirin for 24 weeks. In EASL Guidelines, for treatment of naive and experienced patients there are two options: sofosbuvir and velpatasvir with or without ribavirin and sofosbuvir and daclatasvir with or without ribavirin [37, 38].
\n
\n
\n
4. Croatian Health Insurance Fund (HZZO)—reimbursement requirements
\n
Croatian Health Insurance Fund (HZZO) is covering over 99% of the population. HCV treatments are funded from a separate budget for expensive medicines [39]. HZZO has listed conditions that patients have to fulfill in order for HCV treatment to be covered from the before-mentioned fund: age between 18 and 70 years, HCV RNA positive, with a specified genotype, histologic evidence of chronic inflammation (biopsy finding) or fibroscan result larger than 8 kPa, and abstinence of IDU and significant alcohol consumption for the past 12 months. In patients with normal alanine aminotransferase (ALT) level, treatment is indicated with fibrosis F ≥ 2 or fibroscan finding >8 kPa. Patients who are IDUs need to have evidence of abstinence from illegal substances for at least one year and documented psychiatrist\'s finding and results of toxicology testing every 3 months during medical treatment. Treatment reimbursement requirements in Croatia include: specialist recommendation for treatment, Hospital\'s drug committee approval, and request for treatment sent to Expert committee for the treatment of hepatitis C of HZZO for final approval of treatment modality and duration (respect priorities among patients). All other Croatian patients with chronic hepatitis C (not fulfilling the above-mentioned requirements) can also be treated based on the judgment of the treating physician, but with a more restricted reimbursement options.
\n
\n
\n
5. Conclusion
\n
Regarding improvements in therapy and prevention, clinical care for patients with HCV in Croatia has advanced significantly during the past two years. Comparing epidemiology, indications for the treatment, available drugs, and therapeutic protocols, it is clear that Croatia accompanies European trends in HCV treatment. In future, rapid changes in the treatment of chronic HCV infection with the innovation of new drugs will lead to more effective, shorter treatment courses and PegIFN-free modalities.
\n
\n\n',keywords:"hepatitis C virus, Croatia, epidemiology, treatment, direct-acting antivirals (DAAs)",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/56687.pdf",chapterXML:"https://mts.intechopen.com/source/xml/56687.xml",downloadPdfUrl:"/chapter/pdf-download/56687",previewPdfUrl:"/chapter/pdf-preview/56687",totalDownloads:1245,totalViews:231,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:10,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:"November 23rd 2016",dateReviewed:"July 20th 2017",datePrePublished:null,datePublished:"October 4th 2017",dateFinished:"August 8th 2017",readingETA:"0",abstract:"The prevalence of hepatitis C virus (HCV) antibodies in Croatia is low in the general population (reported <1%), similar to the prevalence rates of many European countries, but is higher in the populations at risk, especially among intravenous drug users. With the development of new classes of direct-acting antiviral agents and interferon-free regimens, the landscape of HCV treatment has completely changed. Management of HCV infection in Croatia is in accordance with the European Association for the Study of the Liver (EASL) recommendations published in 2015, recently updated Croatian Guidelines (published in April 2016) and the recommendations of Croatian Health Insurance Fund (HZZO) which covers the costs of treatment. HZZO approved simeprevir at the beginning of 2015. By the end of the 2015 sofosbuvir, combination of sofosbuvir + ledipasvir and the combination of ombitasvir, paritaprevir and ritonavir ± dasabuvir became available. Although the drawback of these new highly effective treatments is their price, prioritization of patients on a national level offers equal opportunities to patients in need for treatment. Due to improvements in therapy and prevention, clinical care for patients with HCV in Croatia advanced significantly during the last two years.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/56687",risUrl:"/chapter/ris/56687",book:{id:"6014",slug:"update-on-hepatitis-c"},signatures:"Marko Duvnjak, Nina Blažević and Lucija Virović Jukić",authors:[{id:"202346",title:"Dr.",name:"Marko",middleName:null,surname:"Duvnjak",fullName:"Marko Duvnjak",slug:"marko-duvnjak",email:"marko.duvnjak1@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"202360",title:"Dr.",name:"Lucija",middleName:null,surname:"Virovic-Jukic",fullName:"Lucija Virovic-Jukic",slug:"lucija-virovic-jukic",email:"lucija.jukic@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"204985",title:"Dr.",name:"Nina",middleName:null,surname:"Blazevic",fullName:"Nina Blazevic",slug:"nina-blazevic",email:"nina.blazevic05@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Indications for treatment in Europe and Croatia",level:"1"},{id:"sec_3",title:"3. Therapeutic protocol",level:"1"},{id:"sec_4",title:"4. Croatian Health Insurance Fund (HZZO)—reimbursement requirements",level:"1"},{id:"sec_5",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Muñoz-Gámez JA, Salmerón J. Prevalence of hepatitis B and C in Spain – further data are needed. Revista Española de Enfermedades Digestivas. 2013;105:245-248\n'},{id:"B2",body:'Meffre C, Le Strat Y, Delarocque-Astagneau E, et al. Prevalence of hepatitis B and hepatitis C virus infections in France in 2004: Social factors are important predictors after adjusting for known risk factors. Journal of Medical Virology. 2010;82:546-555\n'},{id:"B3",body:'Van Damme P, Thyssen A, Van Loock F. Epidemiology of hepatitis C in Belgium: Present and future. Acta Gastro-Enterologica Belgica. 2002;65:78-79\n'},{id:"B4",body:'Gańczak M, Szych Z. 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Introduction and utilization of high priced HCV medicines across Europe: Implications for the future. Frontiers in Pharmacology. 2016;7:197\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Marko Duvnjak",address:"marko.duvnjak1@gmail.com",affiliation:'
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
University of Zagreb School of Medicine, Zagreb, Croatia
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
University of Zagreb School of Medicine, Zagreb, Croatia
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1. Introduction
With the evolution of the human being from the time of the Homo’s, they tried to survive and explore nature (the environment). In 1859 Charles Darwin (1809–1882) published his book entitled the origin of the species [1], where he described that the species that would survive be those that adapted more quickly to its environment or the change of the environment. In such a way that a struggle for survival was generated and later for the observation of nature, learning, and understanding of it, answering questions that were raised and that nowadays, the scientific community continues to make new questions about it.
The advance of science and technology has grown thanks to a set of multidisciplinary groups generating knowledge and developing what we know as technology, however, some scientists have excelled for their most relevant contributions. This is the case of the area of physics as a cornerstone in the strengthening of science, which has had transcendental epochs, so to speak, since the time of ancient, classical, modern, and contemporary physics. For example, in ancient Greece, the knowledge developed and established up to that time was manifested by the natural philosophy of Aristotle (384–322 AC). At that time Democritus (460–370 BC) argued for the first time the word atom, which means indivisible and which he described as the smallest part that made up all “things.” This was the first approach to the description of very small things. Later in classical physics, the observations of Galileo Galilei (1564–1642) and Isaac Newton (1643–1727) laid the foundation of the behavior of bodies (dynamics). It was the latter who with his book entitled Mathematical Principles of Natural Philosophy [2], established the behavior of different natural phenomena under mathematical arguments. Similarly, the observations made in the laboratory by Michael Faraday (1791–1867) and the dazzling capacity of James Clerk Maxwell (1831–1879), unify the electricity and magnetism manifested in treaties bearing the same name [3]. And so-the transformation of natural philosophy to physics, classical physics, was presented.
After this, new contributions to knowledge emerged, as did J.J. Thomson (1886–1943), H. Becquerel (1852–1908), M. Plank (1858–1947), E. Rutherford (1871–1937), N. Bohr (1885–1962) E. Schrödinger (1887–1961), J. Chadwick (1891–1974), E. Fermi (1901–1954), and A. Einstein (1879–1955) and the entire generation of modern physics, where they laid the foundations of quantum mechanics and special and general relativity, that is, small particles moving at speeds of light and their interaction with gravity. And in that time a leap was generated in the era of electronics and the advancement of technology with the invention of the transistor made by J. Bardeen (1908–1991), W. H. Brattain (1902–1987), and W.B. Shockley (1910–1989) in 1947. Toward the macroscopic nature, and then microscopic, and later quantum, new questions and advances given by the contemporary physics were presented by P. Dirac (1902–1984), H. Yukawa (1907–1981), J.S. Schwinger (1918–1994), R.P. Feynman (1918–1988), M. Gell-Mann (1929–2019), S. Weinberg (1933–2021), P. Higss (1929- ), the world of elementary particles and their interactions. To generate, this knowledge also originated the technological development implemented in the European Center for Nuclear Research leading to a modern technological development [4].
The need to address gaps in knowledge for the development and manipulation of “very small” things led to the beginning of nanotechnology and its possible applications for the benefit of humanity, as it is in medicine, electronics, food, etc. This chapter presents the interactions of classical physics represented by acoustic waves and modern physics implemented in nanotechnology. All this is integrated as a multidisciplinary knowledge applied to food. This chapter describes the basic notions of acoustic waves and consequently of low and high-intensity ultrasound to continue with the effect of acoustic cavitation. Later, the progress of nanotechnology and how it has been incorporated into the food industry is addressed.
2. Acoustic waves
Acoustic waves have a wide field of application and can be interpreted as the physical science that studies the vibrations and elastic waves, and their interactions with the environment; both in macroscopic systems and in quantum systems (phonons). At the microscopic level, acoustic waves have an intermolecular collision process and unlike electromagnetic waves, a material medium is needed for the propagation of the acoustic wave. At the macroscopic level, acoustic waves have an intermolecular collision process and unlike electromagnetic waves, a material medium is needed for the propagation of the acoustic wave. At the macroscopic level, acoustic waves refer to variations in the amplitude of pressure-dependent on time or stress, so acoustic waves are also known as mechanical waves or elastic waves [5].
The linear wave equation is represented by the expression,
∇2Prt−1c2∂2Prt∂t2=0,E1
where ∇2 is the three-dimensional Laplacian operator, which can be applied to different geometries, and this will depend on the type of wave that is analyzed, which can be flat, cylindrical, and/or spherical waves. P is the acoustic pressure of the wave. r is the position vector of the wave and is given by r=xî+yĵ+xk̂, in cartesian coordinates. î,ĵ,k̂, they are the unit vectors. c is the longitudinal velocity of the propagation medium, t is time, ∂2 represents the second partial derivate of the argument. The expression (1) represents a homogeneous wave equation, that is, it does not matter what or who generates the acoustic wave.
The solution of the harmonic flat wave equation is represented by the expression,
P=Ae−ik∙r−ωt+Beik∙r−ωt,E2
where A and B are constants that can be determined by applying initial and/or boundary conditions; k is the wave propagation vector and is given by k=kxî+kyĵ+kzk̂ , i is the imaginary number, k is the wavenumber, and it is defined as k=ωc.ω is the angular frequency. Also, c can be represented as c=λ·f, where λ is the wavelength and f is the frequency. Finally, λ can also be represented by λ=2πk.
As mentioned in the previous paragraph, acoustic waves need a material medium for propagation, this medium can be solid, liquid, gas, or biological material. There are two main modes for the propagation of acoustic waves, which are longitudinal mode and transverse mode. In the longitudinal mode, the emitted acoustic energy propagates in the same direction in which the acoustic travels; on the contrary, in the transverse mode, the emitted acoustic energy propagates perpendicularly in the direction in which the acoustic wave travels. Figure 1 describes the main modes of propagation of acoustic waves [6].
Acoustic waves have well-defined parameters in steady state. Figure 2 shows the parameters of an acoustic wave represented by a sine wave.
Figure 2.
Sine wave. A→ Amplitude, λ→ Wavelength, T → Period, f → Frequency, P → Pressure, t → Time. Where P is the pressure [Pascal], A is the amplitude of the pressure [meters], t is the time [second], λ is the wavelength [meter], T is the period [second] and f is the frequency [Hertz], which T=f−1 or f=T−1, and it is the latter that provides the working spectrum of acoustic waves [7].
In Table 1 the spectrum of acoustic frequencies is described.
Infrasound is an acoustic wave whose frequency is below the audible spectrum of the human ear; some animals can detect these frequencies. The audible sound is conformed by the spectrum of frequencies that can be perceived by the human ear, such as, for example, the voice, the musical notes. Ultrasound is an acoustic wave whose frequency is above the audible spectrum of the human ear; ultrasound has several applications, such as non-destructive and destructive tests in medical diagnosis and rehabilitation therapies. The hypersound is an acoustic wave whose frequency spectrum is very high and has some applications in medicine and war systems.
In this context, acoustic waves also obey Snell’s law of optics [9], where the incident, reflected, and transmitted waves are involved in a propagation medium, Sinθici=Sinθtct, where θi,θ t, ci, and ct represent the angle of the incident wave, transmitted wave, acoustic longitudinal propagation speed of the incident and transmitted wave, respectively. The phenomenon of attenuation is also presented, which is the loss of energy given the intrinsic properties of the medium of propagation, the frequency, and the thickness thereof, and is represented by the expression,
P=Poe−iαr,E3
where Po is the amplitude of the pressure, i is the imaginary number,α is the coefficient of attenuation of the medium and are included the losses by absorption, diffraction, dispersion, scattering, as well as the object of study; r is the position vector of the acoustic wave, as shown in Figure 3.
Figure 3.
With normal incidence to the surface of the propagation medium, the acoustic waves hit, are reflected and transmitted. α is the attenuation that exists when an incident crosses the propagation medium.
From Figure 3, the following expression can be described,
Pi=P∼ieik·r−ωt,E4
Pr=P∼re−ik·r+ωt,E5
Pt=P∼teik·r−ωt,E6
where Pi, Pr, and Pt, represent the waves of incident waves, reflected, and transmitted. Expressions of pressure with the symbol ∼ represent a constant that can be determined by applying initial and/or boundary conditions.
Finally, all the materials have a very important acoustic property, and it is called the specific acoustic impedance (Rayls) that is given by the product of the volumetric density (kg/m3) and the velocity of propagation (m/s), this is, Z=ρ·c. The specific acoustic impedance is the resistance that material presents to the flow of the propagation of the acoustic wave; it should be noted that in solid materials, the longitudinal and transverse acoustic propagation velocities are considered.
2.1 High-intensity ultrasound
Acoustic waves within the ultrasound spectrum range in frequencies between 16kHz and 1GHz. Ultrasound is divided into two categories, according to their acoustic intensities; low-intensity iltrasound (LIU) and high-intensity ultrasound (HIU). LIU is used for exploratory and characterization purposes; meanwhile, HIU is aimed at modifying the biological, physical, and chemical properties of materials. HIU is divided into three subcategories, according to their acoustic intensities depending on their frequency, as described in Table 2.
Classification of acoustic intensities in high-intensity ultrasound depending on frequency [10].
The ultrasound field uses an ultrasonic sensor, which depends on a piezoelectric for its proper operation, ultrasonic sensor has low and high-intensity applications.
2.2 Piezoelectric materials
Piezoelectric materials are those that when subjected to mechanical stress (pressure) generate electrical polarization through the formation of dipoles causing electrical charges of their surface, from which the potential difference can be determined or measured. On the contrary, applying electrical pulses through both surfaces of the material (potential difference), generated mechanical deformations, or the reverse piezoelectricity effect. There are natural piezoelectric materials (quartz), piezopolymers (polyvinylidene difluoride, PVDF), piezoceramics (lead zirconate titanate, PZT), and piezocomposites (PSMNZT) [11, 12]. Piezoelectric materials have three physical properties—mechanical, electrical, and thermal. The relationship between mechanical and electrical properties has an electromechanical effect owning implicitly the piezoelectricity. The association between electrical and thermal properties as electrothermal effects holds the pyroelectric attributes. Finally, the relation between mechanical and thermal properties has the thermoelastic effect and has thermal pressure traits (Figure 4). The thermomechanical relationship is remarkable, as piezoelectric materials are also pyroelectric, hence, when the electrical charge changes, they become a thermal detector of electromagnetic waves on the infrared spectrum. However, when piezoelectric property exceeds its thermal threshold, loses its mechanical attributes, and keeps the thermal characteristics, retaining the pyroelectric effect.
Figure 4.
Heckmann piezoelectricity diagram [13].
Commercial HIU equipment basically has the same inner components. Figure 5 describes the stages of a HIU system; power supply, signal generator, power amplifier, and the high-intensity acoustic emitter. The high-intensity acoustic emitter has a backing, a pair of ceramic piezoelectric in a sandwich configuration, and an amplifier acoustic horn. The previously described ultrasonic emitters are called Langevin transducers [14].
Figure 5.
High-intensity ultrasound stages.
2.3 High-intensity ultrasound equipment
Ultrasonic baths and ultrasonic emitters (also known as sonotrode or probe types) within academia and research are used for sanitizing purposes (e.g., glassware, spare parts, surgical instruments, ballistics, and among others) because they are easy to handle. There is a wide market for these instruments worldwide, some of these are shown in Figure 6.
The high-intensity acoustic wave within the ultrasound range frequency, under inertial or transient state conditions, induces a phenomenon known as acoustic cavitation, which includes generation, growth, and collapse of bubbles. The phenomenon occurs in the acoustic wave transition from the negative half cycle to the positive half cycle (expansion and compression). In a stable phase, bubbles generate an increase in number oscillating through the acoustic field (Figure 7).
Figure 7.
Description of stable and transient cavitation.
In a transitory state and under stochastics situations, the bubbles collapse causing various effects, such as acoustic microcurrents, nucleation of bubbles, shockwaves, sonoluminescence, radical formation, ultrasonic radiation, streams of cloud- and filamented-shaped bubbles form [18].
There is no general agreement on the area of knowledge that originated the study of the acoustic cavitation phenomenon, however, sonoluminescence, sonophysics, sonochemistry [19, 20, 21], and mechanochemistry [22] are the most likely.
The study of acoustic cavitation has developed various physic-mathematical models to describe detailly the phenomenology. The models represent a single bubble under ideal conditions, the description by Rayleigh [23], describes a spherical bubble embedded in an incompressible fluid, where R is the time-dependent radius of the bubble, R(t), pe is the external pressure of the fluid. pi is the pressure inside the bubble, and ρ is the bulk density; see Figure 8. This model is represented by Eq. (7) and describes the kinetic energy in the system between the differences in the stress of the bubble as it expands through internal pressure and the stress of the fluid through the pressure subjected to the bubble.
Figure 8.
Physical parameters of the bubble, Rayleigh model.
ρRR¨+32ρṘ2=pi−pe,E7
where the points on the R (one and two points) mean first and second derivatives with respect to time (Newton’s notation), respectively.
The Rayleigh–Plesset model [24] was generated afterward. The parameters κ, μ, σ, from the original Rayleigh model were included, they are the polytropic exponent of the gas inside the bubble, the dynamic viscosity, and the surface tension of the fluid, respectively, as shown in Figure 9.
Figure 9.
Physical parameters of the bubble, Rayleigh–Plesset model.
The Rayleigh–Plesset model is represented by Eq. (8),
ρRR¨+32ρṘ2=pgnRnR3κ+pv−pstat−2σR−4μRṘ−pt,E8
with
pgn=2σRn+pstat−pv,E9
and
pt=−pasin2πυat,E10
where Rn is the radius of the resting sphere. pgn is the pressure of the gas inside the bubble. pstat is the static pressure and pv is the vapor pressure. p(t) is the external pressure applied to the wall of the bubble. va is the frequency and pa is the amplitude of the pressure.
Later the Gilmore model was developed [25], as represented by Figure 10 and Eq. (1).
1−ṘCRR¨+321−Ṙ3CṘ2=1+ṘCH+ṘC1−ṘCRdHdR,E11
Figure 10.
Physical parameters of the bubble, Gilmore model.
with
H=∫pr→∞pr=Rdpρρ,E12
pρ=Aρρ0nT−B,E13
pr=R=pstat+2σRnRn3−bRn3R3−bRn3κ−2σR−4μRṘ,E14
pr→∞=pstat+pt,E15
C=c02+nT−1H,E16
where C is the acoustic velocity near the bubble-wall, c0 is the acoustic velocity under normal conditions. H is the enthalpy. A, B and nT are the van der Waals parameters.
Finally, the Keller–Miksis model [26] describes the behavior of a bubble under quasi-real conditions, as given by Eq. (17).
1−ṘCRR¨+32Ṙ21−Ṙ3C=1+ṘCplρ+Rρcdpldt,E17
with
pl=pstat+2σRnRnR3κ−pstat−2σR−4μRṘ−pt,E18
pt=pasin2πυat.E19
Acoustic cavitation in a stable state given the oscillation in the acoustic field generates bubbles and divides them. On the other hand, acoustic cavitation in a transient state refers to the variation of pressure in short periods with respect to time and the breakage of the molecular bonds of the fluid, which will increase rapidly the temperature [27], as seen in Figure 11.
Figure 11.
Bubble generation transitions, growth, and collapse, in a transitory state.
If a fluid (liquid) is under shear stress, the bubbles within the fluid increase in size, hence, bubbles are generated within the fluid. The cavities with vapor increase their size until reaching a maximum volume, therefore, when the wave changes pressure from peak to valley, transforms potentials energy into kinetic energy during the implosion. The cavities collapse to sizes even smaller than the originally generated bubbles [28].
The implosions of the bubbles neighboring the surface of an interface are asymmetric; hence, they form microcurrents of the fluid that impinge on the surface of the interface. The average speed of the microcurrents is between 100 and 340 m/s; and they are dependent on the pressure profile and the initial diameter of the bubbles, which ranged between 10 and 100 μm [29].
There are two main types of formations in the generation and accumulation of bubbles in an acoustic field—bubble clouds and bubble filaments, as seen in Figure 12.
where Ri(t) is the radius of the i-th bubble. ρli is the volumetric density of the fluid outside the i-th bubble. p∞ is the ambient pressure. psit=paisinωt,is the modulated acoustic pressure on the i-th bubble. tRi≡Ricli, cli is the acoustic velocity of the fluid outside the i-th bubble. pli=pgiRit−4ηṘiRi−2σRi,is the pressure on the fluid on the side of the i-th bubble wall.
3. Nanomaterials
Metrology states that in the international system of units, the meter [m] is the unit of measure of the length and is defined as the length of the path traveled by the light in the vacuum in a span of 1/299792458 of a second. Its primary standard or reference is at the International Office of Weights and Measures in Sévres, France. In such a way that its submultiples are given by cm, mm, nm, pm, etc. [31].
The unit of measure of the length is the origin to the reference of nanotechnology, due to the dimensions that the latter represents. Nanotechnology can be interpreted with the architecture of functional system and manipulation at nanometric scales, this is one billionth of the meter (1×10−9→ 0.000000001m) [32]. Figure 13 shows the comparison of sizes of some objects.
Figure 13.
Dimension comparison.
It all started in the American physics congress of 1959 when Richard P. Feynman gave a lecture entitled, “There´s plenty of room at the bottom” [33], and with this, he glimpsed the pioneering work of nanotechnology. Feynman described that it would be possible to manipulate systems at the atomic level individually with high-precision instruments. Also, he would be the first to propose the vision of quantum computing. In this way, the race for the exploration and development of nanotechnology and consequently of nanomaterials began [34, 35, 36, 37, 38, 39, 40]. So, a revolution in applications, such as the case of food.
There is a wide variety of nanomaterials, however, the main applications are by means of simple nanoparticles, nanoemulsion, liposome, nanostructured lipid carrier, multilayer nanoparticles, agglomerated nanoparticles, nanofilms, and nanocomposites [41]. There are five areas where studies and development in the field of food are focused [42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60], as seen in Figure 14.
Figure 14.
The five main areas in the study of food.
Subsequently, the interaction of nanomaterials and food interact on three fundamental processes [61, 62, 63, 64], as shown in Figure 15.
Figure 15.
Applications of nanomaterials in food, by means of the Sierpinski triangle.
In recent years, high-intensity ultrasound has been applied to foods involving nanomaterials and obtaining interesting results. Figure 16 shows the interaction of the HIU and the fields of study in nanomaterials focused on food [65, 66, 67].
Figure 16.
HIU application in nanomaterials.
4. Conclusions
Food is a fundamental part of the growth and development of the human being and has changed over time due to current needs. Today the agri-food industry has to use and apply every tool and technology within its reach due to consumer demands. This happens throughout the traceability procedure as it is in the processing, treatment, conservation, and distribution of food. Therefore, alternative or emerging tools are applied, which are different from thermal ones, whose objective is to increase the nutritional properties of foods with benefit for society. In addition to the conjugation of hybrid systems, such as the implementation of nanomaterials applying modern technologies. In this chapter, high-intensity ultrasound and the effect of acoustic cavitation were explained in a simple way, as a tool that is applied to food. Thus, the application of nanomaterials in the main areas of food was also superficially described. Even so, academic and laboratory studies are still being presented to explore the short-range impacts of these hybrid tools. However, there is the possibility of taking it to large-scale production levels, with the aim of carrying out acceptance and quality tests. Subsequently, the final impacts are to implement it in the food industry worldwide. Also, why not say so, have them as another utensil in every home.
Acknowledgments
R.A.R.V. acknowledges the support provided by Investigador por México-CONACYT.
Conflict of interest
The authors declare that they have no known competing financial interest or personal relationship that could have appeared to influence the work reported in this material.
\n',keywords:"acoustic waves, acoustic cavitation, dairy, foods, high-intensity ultrasound, meat, nanotechnology, nanomaterials, ultrasound",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/81452.pdf",chapterXML:"https://mts.intechopen.com/source/xml/81452.xml",downloadPdfUrl:"/chapter/pdf-download/81452",previewPdfUrl:"/chapter/pdf-preview/81452",totalDownloads:12,totalViews:0,totalCrossrefCites:0,dateSubmitted:"February 7th 2022",dateReviewed:"March 9th 2022",datePrePublished:"April 21st 2022",datePublished:null,dateFinished:"April 21st 2022",readingETA:"0",abstract:"In recent decades, food research has focused on hybrid systems, that is, the application of nanomaterials and the so-called emerging technologies, whose objective is to increase the quality of food. Among these technologies that are different from thermal is high intensity ultrasound. This chapter presents and describes the interaction of acoustic waves supported by classical physics and nanomaterials generated by nanotechnology carried out in contemporary physics, all integrated as a multidisciplinary knowledge applied to food. Acoustic waves have a spectrum called ultrasound, with an approximate frequency range between 20 kHz and 1 GHz, and this is divided into low-intensity ultrasound (LIU), whose objective is to characterize materials. On the contrary, high-intensity ultrasound (HIU) has the objective of carrying out destructive tests, modifying the study samples. This happens because the HIU generates a phenomenon called acoustic cavitation, which consists of the generation, growth, and implosion of microbubbles, causing alterations in the near and far acoustic field. The proposed review focuses on the application of high-intensity ultrasound to be used in the food industry. Subsequently, a brief approach is made to nanotechnology and nanomaterials and how they have been incorporated into the food industry.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81452",risUrl:"/chapter/ris/81452",signatures:"Ana Luisa Rentería-Monterrubio, América Chávez-Martínez, Julianna Juárez-Moya, Rogelio Sánchez Vega, Juan Manuel Tirado and Raúl Alberto Reyes-Villagrana",book:{id:"11741",type:"book",title:"Trends and Innovations in Food Science",subtitle:null,fullTitle:"Trends and Innovations in Food Science",slug:null,publishedDate:null,bookSignature:"Prof. Yehia El-Samragy",coverURL:"https://cdn.intechopen.com/books/images_new/11741.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80356-066-3",printIsbn:"978-1-80356-065-6",pdfIsbn:"978-1-80356-067-0",isAvailableForWebshopOrdering:!0,editors:[{id:"81644",title:"Prof.",name:"Yehia",middleName:null,surname:"El-Samragy",slug:"yehia-el-samragy",fullName:"Yehia El-Samragy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Acoustic waves",level:"1"},{id:"sec_2_2",title:"2.1 High-intensity ultrasound",level:"2"},{id:"sec_3_2",title:"2.2 Piezoelectric materials",level:"2"},{id:"sec_4_2",title:"2.3 High-intensity ultrasound equipment",level:"2"},{id:"sec_5_2",title:"2.4 Acoustic cavitation",level:"2"},{id:"sec_7",title:"3. Nanomaterials",level:"1"},{id:"sec_8",title:"4. Conclusions",level:"1"},{id:"sec_9",title:"Acknowledgments",level:"1"},{id:"sec_12",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Darwin CR. On the Origin of Species by Means of Natural Selection, or Preservation of Favored Races in the Struggle for Life. 1st ed. London: John Murray; 1859'},{id:"B2",body:'Newton I. Philosophia Naturalis Principia Mathematica. 1st ed. London: Royal Society; 1686'},{id:"B3",body:'Maxwell JC. A Treatise on Electricity and Magnetism. 1st ed. 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USA: Cambridge University Press; 1999'},{id:"B10",body:'Mason TJ, Chemat F, Ashokkumar M. Mint: Power ultrasonics for food processing. In: Gallegos-Juárez JA, Graff KF, editors. Power Ultrasonics, Applications of High-Intensity Ultrasound. 2015. pp. 815-843'},{id:"B11",body:'Arnau E, editor. Piezoelectric Transducers and Applications. 2nd ed. Berlin: Springer-Verlag; 2008'},{id:"B12",body:'Szabo TL, Lewin PA. Mint: Piezoelectric materials for imaging. Journal of Ultrasound in Medicine. 2007;26:283-288'},{id:"B13",body:'Nye JF. Physical Properties of Crystals: Their Representation by Tensors and Matrices. UK: Oxford University Press; 1985'},{id:"B14",body:'Giraud F, Giraud-Audine C. Piezoelectric Actuators: Vector Control Method, Basic, Modelling and Mechatronic Design of Ultrasonic Devices. 1st ed. Oxford: Butterworth-Heinemann Elsevier; 2019'},{id:"B15",body:'Feng H, Yang W, Hielscher T. Mint: Power ultrasound. 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Mint: On the pressure developed in a liquid during the collapse of a spherical cavity. Philosophical Magazine Series. 1917;6:94-102'},{id:"B24",body:'Leighton TG. The Acoustic Bubbles. 1st ed. Cambridge: Elsevier Academic Press; 2012'},{id:"B25",body:'Gilmore, F. R., Mint: The Growth of Collapse of a Spherical Bubble in a Viscous Compressible Liquid. Report No 26-30, Hydrodynamics Laboratory, California Institute of Technology, Pasadena, California, USA, 1952, 1-41.'},{id:"B26",body:'Keller JB, Miksis M. Mint: Bubble oscillations of large amplitude. Journal of the Acoustic Society of America. 1980;68:628-633'},{id:"B27",body:'Suslick KS, Flannigan DJ. Mint: Inside a collapsing bubble: Sonoluminescence and the conditions during cavitation. Annual Review of Physical Chemistry. 2008;59:659-683'},{id:"B28",body:'Suslick KS, Flint EB. Mint: The temperature of cavitation. Science. 1991;253:1397-1399'},{id:"B29",body:'Lauterborn W, Kurz T. Mint: Physics of bubble oscillations. Reports on Progress in Physics. 2010;73:106501'},{id:"B30",body:'An Y. Mint: Formulation of multibubble cavitation. Physical Review E. 2011;83:066313'},{id:"B31",body:'Hebra AJ. The Physics of Metrology. New York: Springer; 2010'},{id:"B32",body:'Borisenko VE, Ossicini S. What is What in the Nanoworld. Germany: Wiley-VCH; 2008'},{id:"B33",body:'Feynmann RP. There’s Plenty of Room at the Bottom. Pasadena, CA.: American Physical Society; 1959'},{id:"B34",body:'Chaudhry Q, Castle L, Watkins R, editors. Nanotechnologies in Foods. UK: RSC Publishing; 2010'},{id:"B35",body:'Boye JI, Arcand Y. Green Technologies in Food Production and Processing. New York: Springer; 2012'},{id:"B36",body:'Amalraj A, Gopi S, Thomas S, Haponiuk JT. Mint: Cellulose nanomaterials in biomedical, food, and nutraceutical applications: A review. Macromolecular Symposia. 2018;380:1800115'},{id:"B37",body:'Gallocchio F, Belluco S, Ricci A. Mint: Nanotechnology and food: Brief over of the current scenario. Food Science. 2015;5:85-88'},{id:"B38",body:'Rahidi L, Khosravi-Darani K. Mint: The applications of nanotechnology in food industry. Reviews in Food Science and Nutritions. 2011;51:723-730'},{id:"B39",body:'Chau CF, Wu SH, Yen GC. Mint: The development of regulation for food nanotechnologies. Trends in Foods Science & Technologies. 2007;18:269-280'},{id:"B40",body:'Hamad AF, Han JH, Kim BC, Rather IA. Mint: The interwine of nanotechnology with the food industry. Saudi Journal of Biological Sciences. 2018;25:27-30'},{id:"B41",body:'Sattler KD, editor. Handbook of Nanophysics. USA: CRC Press; 2011'},{id:"B42",body:'Vasilescu A, Hayat A, Gáspar S, Marty JL. Mint: Advantages of carbon nanomaterials electrochemical apta sensors for food analysis. Electroanalysis. 2018;30:2-19'},{id:"B43",body:'Tripathi RM, Puddake RN, Shrivastav BR, Shrivastav A. Mint: Antibacterial activity of poly (vinyl alcohol) biogenetic silver nanocomposite film for food packaging material. Advanced Natural. 2018;9:025020'},{id:"B44",body:'Ayhan Z, Cimmino S, Esturk O, Duraccio D, Pezzuto M, Silvestre C. Mint: Development of films of novel polypropylene based nanomaterials for food packaging applications. Packaging Technology and Science. 2018;28:289-602'},{id:"B45",body:'Pavlov YS, Revina AA, Souvorova OV, Voropaeva NL, Chekmar DV, Abkhalimov EV, et al. Mint: Electron beam agrobionanotecnologies for agriculture and food industry enable by electron accelerators. IOP Conference Series: Journals of Physics. 2017;941:012098'},{id:"B46",body:'Martirosyan A, Schneider YJ. Mint: Engineerd nanomaterials in food: Implications for food safety and consumer health. International Journal of Environmental Research and Public Health. 2014;11:5720-5750'},{id:"B47",body:'Balestra GM, Fortunati E, Giovanale G, Mazzaglia A. Mint: Innovation nanotechnological tools in plant and food protection. AIP Conference Proceedings. 1990;2018:020017'},{id:"B48",body:'Gnoshinski IV, Khotimchenko SA. Mint: Nanomaterials in consumer’s goods: The problems of risk assessment. IOP Conf. Series: Materials Science and Engineering. 2015;98:012009'},{id:"B49",body:'Aschberger K, Gottardo S, Amenta V, Arena M, Botelho Moniz F, Bauwneester P, et al. Petters, Mint: Nanomateriasl in food, current and future applications and regulatory aspects. Journal of Physics Conference Series. 2015;617:012032'},{id:"B50",body:'Tsagkaris AS, Tzegkas SG, Danezis GP. Mint: Nanomaterials in food packaging: State of the art analysis. Journal of Food Science and Technology. 2018;55:2862-2870'},{id:"B51",body:'He X, Hwang HM. Mint: Nanotechnology in food science: Functionality, applicability, and safety assessment. Journal of Food and Drug Analysis. 2016;24:671-681'},{id:"B52",body:'Padua GW, Wang Q. Nanotechnology Research Methods for Foods and Bioproducts. India: Wiley-Blackwell; 2012'},{id:"B53",body:'Wyser Y, Adams M, Avella M, Carlander D, García L, Pieper G, et al. Mint: Outlook and challenges of nanotechnologies for food packaging. Packaging Technology and Science. 2016;29:615-648'},{id:"B54",body:'Bajpai VK, Kamle M, Shukla S, Mahato DK, Chandra P, Hwang SK. Mint: Prospect of using nanotechnology for food preservation, safety, and security. Journal of Food and Drug Analysis. 2018;26:201-214'},{id:"B55",body:'Dimitrijevic M, Karabasil N, Boskovic M, Teodorovic V, Vasilev D, Djordjevic V, et al. Mint: Safety aspects of nanotechnology applications in food packaging. Procedia Food Science. 2015;5:57-60'},{id:"B56",body:'Rossi M, Cubaddad F, Dini L, Terranova ML, Aureli F, Sorbo A, et al. Mint: Scientific basis of nanotechnology, implications for the food sector and future trends. Trends in Food Science and Technology. 2014;40:127-148'},{id:"B57",body:'Chellaram C, Murugaboopathim G, John AA, Sivakumar R, Ganesan S, Krithika S, et al. Mint: Significance of nanotechnology in food industry. APCBEE Procedia. 2014;8:109-113'},{id:"B58",body:'Carbone M, Tommasa Donia D, Sabbatella G, Antiochia R. Mint: Silver nanoparticles in polymeric matrices for fresh food packging. Journal of King South University Science. 2016;28:273-279'},{id:"B59",body:'Bhat S, Tuinier R, Schurtenberger P. Mint: Sponodal decomposition in a food colloid biopolymer mixture: Evidence for a linear regime. Journal of Physics. 2006;18:339-346'},{id:"B60",body:'Lizhao H. Mint: The analysis about the application of nanomaterial in food packaging. IOP Conf. Series: Materials Science and Engineering. 2018;439:042021'},{id:"B61",body:'Awad TS, Moharram HA, Shaltout OE, Asker D, Youssef MM. Mint: Applications of ultrasound in analysis, processing and quality control of food: A review. Food Research International. 2012;48:410-427'},{id:"B62",body:'Abbas S, Hayat K, Karangwa E, Basshari M, Zhang X. Mint: An overview of ultrasound-assisted food-grade nanoemulsions. Foods Engineering Review. 2013;5:139-157'},{id:"B63",body:'Souza VGL, Fernando AL. Mint: Nanoparticles in food packaging: Biodergradability and potential migration to food a review. Food Packaging and Shelf Life. 2016;8:63-70'},{id:"B64",body:'Parakoti K, Manibolu M, Hwang HM. Mint: Nanostructures: Current uses future applications in food science. Journal of Food and Drug Analysis. 2017;25:245-253'},{id:"B65",body:'Bouwmeester H, Van der Zande M, Jepson A. Mint: Effects of food-borne nanomaterials on gastrointenstinal tissue and microbiota. WIRES Nanomd Nanobiotechnology. 2018;10:1481'},{id:"B66",body:'Bumbudsanpharoke N, Ko S. Mint: Nano-food packaging: And overview of market, migration research, and safety regulations. Journal of Food Science. 2015;80:910-923'},{id:"B67",body:'Taurozzi JS, Hackley VA, Wiesner MR. Mint: Ultrasonic dispersion of nanoparticles for environmental, health and safety assessment—issues and recommendations. Nanotoxicology. 2011;5:711-729'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Ana Luisa Rentería-Monterrubio",address:null,affiliation:'
Faculty of Animal Science and Ecology, Autonomous University of Chihuahua, Mexico
Faculty of Animal Science and Ecology, Autonomous University of Chihuahua, Mexico
'},{corresp:null,contributorFullName:"Juan Manuel Tirado",address:null,affiliation:'
Faculty of Animal Science and Ecology, Autonomous University of Chihuahua, Mexico
'},{corresp:"yes",contributorFullName:"Raúl Alberto Reyes-Villagrana",address:"rareyesvi@conacyt.mx",affiliation:'
Faculty of Animal Science and Ecology, Autonomous University of Chihuahua, Mexico
National Council of Science and Technology, Mexico
'}],corrections:null},book:{id:"11741",type:"book",title:"Trends and Innovations in Food Science",subtitle:null,fullTitle:"Trends and Innovations in Food Science",slug:null,publishedDate:null,bookSignature:"Prof. Yehia El-Samragy",coverURL:"https://cdn.intechopen.com/books/images_new/11741.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80356-066-3",printIsbn:"978-1-80356-065-6",pdfIsbn:"978-1-80356-067-0",isAvailableForWebshopOrdering:!0,editors:[{id:"81644",title:"Prof.",name:"Yehia",middleName:null,surname:"El-Samragy",slug:"yehia-el-samragy",fullName:"Yehia El-Samragy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"241233",title:"BSc.",name:"Yapan",middleName:null,surname:"Huang",email:"1214538740@qq.com",fullName:"Yapan Huang",slug:"yapan-huang",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"3",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"62324",title:"Transparent Conducting Thin Film Preparation of Carbon Nanotube",slug:"transparent-conducting-thin-film-preparation-of-carbon-nanotube",abstract:"Transparent conducting films have a wide range of applications in the fields of flat panel displays, solar cells, and touch panels for their both good conductivity and light transmittance. Carbon nanotubes (CNTs) transparent conducting film has become a potential alternative for next-generation transparent conducting film systems owing to high conductivity, light transmittance and flexibility. The multiwalled carbon nanotubes (MWCNTs) conductive liquid was prepared by dispersing MWCNTs in alcohol through ultrasonic and high-speed shearing process with an addition of carbon nanotube alcohol dispersant (TNADIS) as the dispersant. The transparent conducting film was fabricated on polyethylene terephthalate (PET) transparent film by spin-coating process. The film was used as interlayer between the electrode and the separator to improve electrochemical performance of lithium-sulfur (Li-S) batteries.",signatures:"Xiaogang Sun, Jie Wang, Wei Chen, Xu Li, Manyuan Cai, Long Chen, Zhiwen Qiu, Yapan Huang, Chengcheng Wei, Hao Hu and Guodong Liang",authors:[{id:"25405",title:"Prof.",name:"Xiaogang",surname:"Sun",fullName:"Xiaogang Sun",slug:"xiaogang-sun",email:"xiaogangsun@163.com"},{id:"209415",title:"Mr.",name:"Jie",surname:"Wang",fullName:"Jie Wang",slug:"jie-wang",email:"464425175@qq.com"},{id:"217387",title:"BSc.",name:"Manyuan",surname:"Cai",fullName:"Manyuan Cai",slug:"manyuan-cai",email:"574419628@qq.com"},{id:"217388",title:"BSc.",name:"Long",surname:"Chen",fullName:"Long Chen",slug:"long-chen",email:"1083192075@qq.com"},{id:"217389",title:"BSc.",name:"Zhiwen",surname:"Qiu",fullName:"Zhiwen Qiu",slug:"zhiwen-qiu",email:"821112952@qq.com"},{id:"217390",title:"BSc.",name:"Xu",surname:"Li",fullName:"Xu Li",slug:"xu-li",email:"1255064662@qq.com"},{id:"217391",title:"BSc.",name:"Wei",surname:"Chen",fullName:"Wei Chen",slug:"wei-chen",email:"543405660@qq.com"},{id:"241233",title:"BSc.",name:"Yapan",surname:"Huang",fullName:"Yapan Huang",slug:"yapan-huang",email:"1214538740@qq.com"},{id:"241234",title:"BSc.",name:"Chengcheng",surname:"Wei",fullName:"Chengcheng Wei",slug:"chengcheng-wei",email:"1040956172@qq.com"},{id:"241235",title:"BSc.",name:"Hao",surname:"Hu",fullName:"Hao Hu",slug:"hao-hu",email:"1427915404@qq.com"},{id:"241236",title:"BSc.",name:"Guodong",surname:"Liang",fullName:"Guodong Liang",slug:"guodong-liang",email:"1131176922@qq.com"}],book:{id:"6785",title:"Transparent Conducting Films",slug:"transparent-conducting-films",productType:{id:"1",title:"Edited Volume"}}},{id:"63065",title:"Performance and Applications of Lithium Ion Capacitors",slug:"performance-and-applications-of-lithium-ion-capacitors",abstract:"Lithium-ion capacitors (LICs) have a wide range of applications in the fields of hybrid electric vehicles (HEVs) and electric vehicles (EVs) for their both high energy density and high power density. Lithium-ion capacitors have become a potential alternative for next-generation chemical energy storage equipment owing to high energy density, high power density, and excellent cycle performance. The prelithiated multiwalled carbon nanotubes (MWCNTs) electrode was prepared by internal short circuit (ISC) and doping to intercalate lithium into MWCNTs. SLMP and lithium metal were used as lithium resources, respectively. The prelithiated carbon nanotubes were used as anode and activated carbon electrode as cathode. The capacitors were assembled in a glove box filled with argon. The prelithiated MWCNTs electrode eliminated irreversible capacity and improved substantially electrochemical performance of lithium-ion capacitors.",signatures:"Xiaogang Sun, Wei Chen, Xu Li, Jie Wang, Hao Hu, Guodong Liang,\nYapan Huang and Chengcheng Wei",authors:[{id:"25405",title:"Prof.",name:"Xiaogang",surname:"Sun",fullName:"Xiaogang Sun",slug:"xiaogang-sun",email:"xiaogangsun@163.com"},{id:"209415",title:"Mr.",name:"Jie",surname:"Wang",fullName:"Jie Wang",slug:"jie-wang",email:"464425175@qq.com"},{id:"217390",title:"BSc.",name:"Xu",surname:"Li",fullName:"Xu Li",slug:"xu-li",email:"1255064662@qq.com"},{id:"217391",title:"BSc.",name:"Wei",surname:"Chen",fullName:"Wei Chen",slug:"wei-chen",email:"543405660@qq.com"},{id:"241233",title:"BSc.",name:"Yapan",surname:"Huang",fullName:"Yapan Huang",slug:"yapan-huang",email:"1214538740@qq.com"},{id:"241234",title:"BSc.",name:"Chengcheng",surname:"Wei",fullName:"Chengcheng Wei",slug:"chengcheng-wei",email:"1040956172@qq.com"},{id:"241235",title:"BSc.",name:"Hao",surname:"Hu",fullName:"Hao Hu",slug:"hao-hu",email:"1427915404@qq.com"},{id:"241236",title:"BSc.",name:"Guodong",surname:"Liang",fullName:"Guodong Liang",slug:"guodong-liang",email:"1131176922@qq.com"}],book:{id:"7567",title:"Science, Technology and Advanced Application of Supercapacitors",slug:"science-technology-and-advanced-application-of-supercapacitors",productType:{id:"1",title:"Edited Volume"}}},{id:"65723",title:"Flexible Porous Carbon Nanotube Films Intercalated with Active and Functional Materials for Lithium-Ion Batteries",slug:"flexible-porous-carbon-nanotube-films-intercalated-with-active-and-functional-materials-for-lithium-",abstract:"Lithium-ion battery (LIB) has occupied the main position of portable electronic devices, and it is also playing an important role in energy storage and large energy storage. Thin film devices based on their diverse functions have great potential for wide application. Novel thin film devices need to be created for the improvement of electrochemical performance and safety of LIB. Our research focused on transparent conductive films and new flexible porous carbon nanotube films for improving and enhancing the energy/power density and cyclic performance of LIB. Meanwhile, different carbon nanotube films have their own additional advantages in strength and thermal conductivity to meet various functional requirements of LIBS.",signatures:"Xiaogang Sun, Xu Li, Wei Chen, Jie Wang, Chengcheng Wei, Yapan Huang, Guodong Liang and Hao Hu",authors:[{id:"25405",title:"Prof.",name:"Xiaogang",surname:"Sun",fullName:"Xiaogang Sun",slug:"xiaogang-sun",email:"xiaogangsun@163.com"},{id:"209415",title:"Mr.",name:"Jie",surname:"Wang",fullName:"Jie Wang",slug:"jie-wang",email:"464425175@qq.com"},{id:"217390",title:"BSc.",name:"Xu",surname:"Li",fullName:"Xu Li",slug:"xu-li",email:"1255064662@qq.com"},{id:"217391",title:"BSc.",name:"Wei",surname:"Chen",fullName:"Wei Chen",slug:"wei-chen",email:"543405660@qq.com"},{id:"241233",title:"BSc.",name:"Yapan",surname:"Huang",fullName:"Yapan Huang",slug:"yapan-huang",email:"1214538740@qq.com"},{id:"241234",title:"BSc.",name:"Chengcheng",surname:"Wei",fullName:"Chengcheng Wei",slug:"chengcheng-wei",email:"1040956172@qq.com"},{id:"241235",title:"BSc.",name:"Hao",surname:"Hu",fullName:"Hao Hu",slug:"hao-hu",email:"1427915404@qq.com"},{id:"241236",title:"BSc.",name:"Guodong",surname:"Liang",fullName:"Guodong Liang",slug:"guodong-liang",email:"1131176922@qq.com"}],book:{id:"6837",title:"Lithium-ion Batteries",slug:"lithium-ion-batteries-thin-film-for-energy-materials-and-devices",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"25405",title:"Prof.",name:"Xiaogang",surname:"Sun",slug:"xiaogang-sun",fullName:"Xiaogang Sun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"209415",title:"Mr.",name:"Jie",surname:"Wang",slug:"jie-wang",fullName:"Jie Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"217387",title:"BSc.",name:"Manyuan",surname:"Cai",slug:"manyuan-cai",fullName:"Manyuan Cai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"217388",title:"BSc.",name:"Long",surname:"Chen",slug:"long-chen",fullName:"Long Chen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"217389",title:"BSc.",name:"Zhiwen",surname:"Qiu",slug:"zhiwen-qiu",fullName:"Zhiwen Qiu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"217390",title:"BSc.",name:"Xu",surname:"Li",slug:"xu-li",fullName:"Xu Li",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"217391",title:"BSc.",name:"Wei",surname:"Chen",slug:"wei-chen",fullName:"Wei Chen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"241234",title:"BSc.",name:"Chengcheng",surname:"Wei",slug:"chengcheng-wei",fullName:"Chengcheng Wei",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"241235",title:"BSc.",name:"Hao",surname:"Hu",slug:"hao-hu",fullName:"Hao Hu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"241236",title:"BSc.",name:"Guodong",surname:"Liang",slug:"guodong-liang",fullName:"Guodong Liang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"our-story",title:"Our story",intro:"
The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
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2005
\\n\\n
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IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
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2006
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IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
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2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
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2013
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IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
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\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
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IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
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2015
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\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
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40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
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Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
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\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
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2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
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\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
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2016
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\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
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2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
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Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
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He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain. She is a Full Professor at the Department of Medicine and Animal Surgery at the same University. She developed her research activity in the field of Endocrinology, Hematology, Biochemistry and Immunology of horses. She is a scientific reviewer of several international journals : American Journal of Obstetrics and Gynecology, Comparative Clinical Pathology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology. Since 2014, she has been the Head of the Clinical Analysis Laboratory of the Hospital Clínico Veterinario from the Faculty of Veterinary, CEU-Cardenal Herrera University.",institutionString:"CEU-Cardenal Herrera University",institution:{name:"CEU Cardinal Herrera University",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. 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Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"345713",title:"Dr.",name:"Csaba",middleName:null,surname:"Szabó",slug:"csaba-szabo",fullName:"Csaba Szabó",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"345719",title:"Mrs.",name:"Márta",middleName:null,surname:"Horváth",slug:"marta-horvath",fullName:"Márta Horváth",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"420151",title:"Prof.",name:"Novirman",middleName:null,surname:"Jamarun",slug:"novirman-jamarun",fullName:"Novirman Jamarun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}},{id:"420149",title:"Dr.",name:"Rusmana",middleName:"Wijaya Setia",surname:"Wijaya Setia Ningrat",slug:"rusmana-wijaya-setia-ningrat",fullName:"Rusmana Wijaya Setia Ningrat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}},{id:"339759",title:"Mr.",name:"Abu",middleName:null,surname:"Macavoray",slug:"abu-macavoray",fullName:"Abu Macavoray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Njala University",country:{name:"Sierra Leone"}}},{id:"339758",title:"Prof.",name:"Benjamin",middleName:null,surname:"Emikpe",slug:"benjamin-emikpe",fullName:"Benjamin Emikpe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ibadan",country:{name:"Nigeria"}}},{id:"339760",title:"Mr.",name:"Moinina Nelphson",middleName:null,surname:"Kallon",slug:"moinina-nelphson-kallon",fullName:"Moinina Nelphson Kallon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Njala University",country:{name:"Sierra Leone"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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