Simulation scenarios for emergency medical care services delivery.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8781",leadTitle:null,fullTitle:"Weight Management",title:"Weight Management",subtitle:null,reviewType:"peer-reviewed",abstract:"Weight management is a multi- and cross-disciplinary challenge. This book covers many etiological and diagnostic aspects of weight-related disorders and their treatment. This book explains how body weight influences and is influenced by the brain, hormones and immune system, diet, physical activity, posture and gait, and the social environment. This book also elucidates the health consequences of significantly low or pathologically increased body weight. Furthermore, ideas on how to influence and manage body weight including anti-obesity medical devices, diet counselling, artificial sweeteners, prebiotics and probiotics, proanthocyanidins, bariatric surgery, microbiota transplantation, warming, physical exercise, music and psychological therapy are discussed.",isbn:"978-1-83962-543-5",printIsbn:"978-1-83962-542-8",pdfIsbn:"978-1-83962-544-2",doi:"10.5772/intechopen.80199",price:139,priceEur:155,priceUsd:179,slug:"weight-management",numberOfPages:332,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"865bbf7988bae3fdb09bf58d6e6a6cd5",bookSignature:"Hubertus Himmerich",publishedDate:"September 9th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8781.jpg",numberOfDownloads:12873,numberOfWosCitations:4,numberOfCrossrefCitations:12,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:15,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:31,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 2nd 2019",dateEndSecondStepPublish:"January 2nd 2020",dateEndThirdStepPublish:"March 2nd 2020",dateEndFourthStepPublish:"May 21st 2020",dateEndFifthStepPublish:"July 20th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"231568",title:"Dr.",name:"Hubertus",middleName:null,surname:"Himmerich",slug:"hubertus-himmerich",fullName:"Hubertus Himmerich",profilePictureURL:"https://mts.intechopen.com/storage/users/231568/images/system/231568.png",biography:"Dr. Hubertus Himmerich is a clinical senior lecturer for eating disorders at King’s College London and a consultant psychiatrist on an inpatient ward for patients with eating disorders at Bethlem Royal Hospital, London, UK. Following medical school, Dr. Himmerich received his scientific and clinical training at the Max Planck Institute of Psychiatry, Germany, and the Universities of Mainz and Marburg, Germany. Afterwards, he worked as a consultant psychiatrist at the RWTH Aachen University Hospital and Professor of Neurobiology of Affective Disorders at the University of Leipzig, Germany. He has led and performed national and international scientific projects with researchers from Europe, Australia, and North America, and he has published more than 160 articles in peer-reviewed scientific journals, books, and book chapters.",institutionString:"King’s College London",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"King's College London",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1061",title:"Psychiatry",slug:"mental-and-behavioural-disorders-and-diseases-of-the-nervous-system-psychiatry"}],chapters:[{id:"70984",title:"Risk and Maintenance Factors for Eating Disorders: An Exploration of Multivariate Models on Clinical and Non-Clinical Populations",doi:"10.5772/intechopen.91063",slug:"risk-and-maintenance-factors-for-eating-disorders-an-exploration-of-multivariate-models-on-clinical-",totalDownloads:736,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The recognition of factors involved in the development and maintenance of eating disorders (EDs) may support the choice of therapeutic strategies and improve the prevention/treatment of eating pathologies and their outcomes. Based on this consideration, the overall purpose of the chapter is to investigate how some psychological characteristics link to EDs. It is organized as follows. First, the epidemiological aspects, risk, and maintaining factors for ED are outlined. Next, we present the findings from our two studies. The purpose of the first study was to identify predictors associated with the severity of eating symptomatology. Then, the objective of the second study was to provide an understanding of the relationship among perceived parental bonding, self-esteem, perfectionism, body shame, body mass index, and ED risk and mainly to test a predictive ED risk model in a non-clinical sample. In conclusion, the major findings and practical implications are discussed.",signatures:"Stefania Cella, Mara Iannaccone, Annarosa Cipriano and Paolo Cotrufo",downloadPdfUrl:"/chapter/pdf-download/70984",previewPdfUrl:"/chapter/pdf-preview/70984",authors:[{id:"87790",title:"Prof.",name:"Paolo",surname:"Cotrufo",slug:"paolo-cotrufo",fullName:"Paolo Cotrufo"},{id:"312881",title:"Ph.D.",name:"Stefania",surname:"Cella",slug:"stefania-cella",fullName:"Stefania Cella"},{id:"313379",title:"Dr.",name:"Mara",surname:"Iannaccone",slug:"mara-iannaccone",fullName:"Mara Iannaccone"},{id:"317168",title:"Dr.",name:"Annarosa",surname:"Cipriano",slug:"annarosa-cipriano",fullName:"Annarosa Cipriano"}],corrections:null},{id:"72057",title:"Weight Management: Inflammation",doi:"10.5772/intechopen.92380",slug:"weight-management-inflammation",totalDownloads:641,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Nowadays, obesity is considered as one of the fastest escalating nutritional disorders that reached pandemic throughout the world. Obesity is a condition in which overaccumulation of energy in the form of fat happens in an individual’s subcutaneous and/or abdominal visceral tissue. It is described as an abnormal growth of adipose tissue due to the enlargement of fat cell size (hypertrophic obesity) or fat cell number (hyperplastic obesity) or a condition of both. Earlier, it was reported that the most common type of obesity that affects the general population is the polygenic form that results from a result of a positive energy balance between energy consumption and its expenditure – or a combination of both. The pandemic of obesity has enforced to analyze the link between the role of inflammation and complications of overweight and obesity. This led to crossroads of the field of nutrition, diet therapy, physiology, immunology, and epidemiology and makes the understanding that they are linked inexplicably. The remodeling of obesity as an inflammatory state has led a wide impression in our conceptualization of obesity-related diseases. In this chapter, we highlight the endocrine aspect of adipose tissue, the effect of dysregulated secretion of adipokines due to inflammation and dietary components that affect obesity related to inflammation.",signatures:"Upasana",downloadPdfUrl:"/chapter/pdf-download/72057",previewPdfUrl:"/chapter/pdf-preview/72057",authors:[{id:"317799",title:"Dr.",name:"Upasana",surname:"Upasana",slug:"upasana-upasana",fullName:"Upasana Upasana"}],corrections:null},{id:"71777",title:"Orexin and Psychoneurobiology: A Hidden Treasure",doi:"10.5772/intechopen.91852",slug:"orexin-and-psychoneurobiology-a-hidden-treasure",totalDownloads:644,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Orexin is a neuropeptide secreted from the lateral hypothalamus and prefrontal cortex concerned in wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin. A diversity of search strategies was adopted and assumed which included electronic database searches of Medline and PubMed using MeSH terms, keywords, and title words. Orexin plays a vital role in activation of learning, memory acquisition, and consolidation through activation of the monoaminergic system, which affects cognitive flexibility and cognitive function. Orexin stimulates adrenocorticotrophin (ACTH) and corticosteroid secretions via activation of the central corticotropin-releasing hormone (CRH). Cerebrospinal (CSF) and serum orexin serum levels are reduced in depression, schizophrenia, and narcolepsy. However, high orexin serum levels are revealed in drug addictions. Regarding neurodegenerative brain diseases, CSF and serum orexin levels are reduced in Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Orexin antagonist leads to significant reduction of sympathetic overactivity during withdrawal syndrome. Also, orexin antagonist improves sleep pattern. The orexinergic system is involved in different psychiatric and neurological disorders; therefore targeting of this system could be a possible novel pathway in the management of these disorders. In addition measurement of CSF and serum orexin levels might predict the relapse and withdrawal of addict patients.",signatures:"Hayder M. Alkuraishy, Ali I. Al-Gareeb and Naseer A. Al-Harchan",downloadPdfUrl:"/chapter/pdf-download/71777",previewPdfUrl:"/chapter/pdf-preview/71777",authors:[{id:"306350",title:"Prof.",name:"Hayder M.",surname:"Al-kuraishy",slug:"hayder-m.-al-kuraishy",fullName:"Hayder M. Al-kuraishy"},{id:"320583",title:"Dr.",name:"Ali I.",surname:"Al-Gareeb",slug:"ali-i.-al-gareeb",fullName:"Ali I. Al-Gareeb"},{id:"320584",title:"Dr.",name:"Naseer A.",surname:"Al-Harchan",slug:"naseer-a.-al-harchan",fullName:"Naseer A. Al-Harchan"}],corrections:null},{id:"71377",title:"Anorexia Nervosa",doi:"10.5772/intechopen.91278",slug:"anorexia-nervosa",totalDownloads:600,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Anorexia nervosa is characterized as having a significantly low body weight because of restricting energy intake or compensating to an excessive rate intentionally in order to attain or maintain an unrealistically thin ideal weight. Patients suffer multiple comorbid medical and psychiatric problems; moreover, deficits in treatment motivation are commonly seen, which causes a high rate of dropout from treatment programs. Thus, recent studies have focused on the etiology in order to develop efficient treatment options, as this can become a life-threatening problem. Prevention programs are also gaining attention, since full recovery can take a significant time and resources nevertheless may not be available for all cases. In this chapter, a brief history and basic diagnostic criteria of anorexia nervosa will be summarized. A review of comorbid psychiatric and medical conditions will be addressed. Prominent theories regarding its etiology and treatment options will be discussed in terms of a biopsychosocial approach. Finally, prevention studies will be highlighted.",signatures:"Fatima Elif Ergüney Okumuş",downloadPdfUrl:"/chapter/pdf-download/71377",previewPdfUrl:"/chapter/pdf-preview/71377",authors:[{id:"314051",title:"Ph.D.",name:"Fatima Elif",surname:"Ergüney Okumuş",slug:"fatima-elif-erguney-okumus",fullName:"Fatima Elif Ergüney Okumuş"}],corrections:null},{id:"72628",title:"Diagnostic Methods in Childhood Obesity",doi:"10.5772/intechopen.92880",slug:"diagnostic-methods-in-childhood-obesity",totalDownloads:588,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Childhood obesity, the most frequent pediatric disease, a worldwide public health problem, is considered a global epidemic and the main risk factor for obesity in adulthood. Among its consequences, cardiovascular and metabolic diseases stand out, which can be diagnosed during childhood, potentiate morbidity and mortality throughout life. Anthropometry, which includes the analysis of body mass index and the measurement of waist circumference, has proven efficacy in pediatric clinical evaluation. However, these diagnostic methods do not differentiate between subcutaneous and intra-abdominal or visceral fat. In this sense, diagnostic imaging methods complement the assessment of abdominal fat. In children, ultrasography appears as an innocuous, reproducible, and reliable diagnostic imaging method. The importance of knowing diagnostic methods for better monitoring of childhood obesity is emphasized.",signatures:"Leonardo de Souza Piber, Patrícia Colombo-Souza and Jane de Eston Armond",downloadPdfUrl:"/chapter/pdf-download/72628",previewPdfUrl:"/chapter/pdf-preview/72628",authors:[{id:"319391",title:"Ph.D.",name:"Patrícia",surname:"Colombo-Souza",slug:"patricia-colombo-souza",fullName:"Patrícia Colombo-Souza"},{id:"319394",title:"MSc.",name:"Leonardo",surname:"de Souza Piber",slug:"leonardo-de-souza-piber",fullName:"Leonardo de Souza Piber"},{id:"321614",title:"Dr.",name:"Jane",surname:"de Eston Armond",slug:"jane-de-eston-armond",fullName:"Jane de Eston Armond"}],corrections:null},{id:"71076",title:"Obesity: A Risk Factor for Infection after Surgery",doi:"10.5772/intechopen.91216",slug:"obesity-a-risk-factor-for-infection-after-surgery",totalDownloads:719,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Obesity is a prevalent health problem all over the world. It is associated with several diseases including infections. It impairs the immune system function by plenty of mechanisms. For instance, leptin and adiponectin are cytokines produced by the adipose tissue, both participating in immunity, but their effects are impaired in obese patients. Moreover, immune cells also show defects in their functions. They produce a pro-inflammatory state and contribute to obesity-related diseases. Innate immune system and adaptive immunity are both impaired in obese patients which causes a poor response to infections. In addition, in surgical site infections (SSI), there are local factors that must be considered. The large adipose panicle and visceral adipose tissue increase the surgical technique difficulty and extend the operative time. Besides, the adipose tissue has poor oxygenation and reduces operative field. It has been proven that obesity is associated to surgical site infection irrespective of type of surgery. However, minimal invasive surgery has demonstrated that reducing surgical trauma can diminish the risk for surgical site infection.",signatures:"José Alonso Suclla-Velásquez and Connie Smedts",downloadPdfUrl:"/chapter/pdf-download/71076",previewPdfUrl:"/chapter/pdf-preview/71076",authors:[{id:"314098",title:"M.D.",name:"José Alonso",surname:"Suclla-Velásquez",slug:"jose-alonso-suclla-velasquez",fullName:"José Alonso Suclla-Velásquez"},{id:"314101",title:"Ms.",name:"Connie",surname:"Smedts",slug:"connie-smedts",fullName:"Connie Smedts"}],corrections:null},{id:"71381",title:"Calcium Dyshomeostasis in Neuropathy Diabetes",doi:"10.5772/intechopen.91482",slug:"calcium-dyshomeostasis-in-neuropathy-diabetes",totalDownloads:1308,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Diabetes is a ceaseless ailment that is basic in practically all nations. Neuropathy is the most well-known constant difficulty of diabetes and is the underlying reason for ulceration in the legs of lower appendage removals. The predominance of diabetic polyneuropathy shifts from 23 to 29%. Incessant metabolic pressure incited by hyperglycemia, either low insulin creation in type 1 diabetes or diminished fringe affectability to insulin in type 2 diabetes influences cell homeostasis in practically all phone types. Changes in the sign Ca2+ have been recognized in different seclusion tissues from creatures initiated to diabetes just as patients with diabetes. Ca2+ homeostasis variations from the norm have likewise been found in an assortment of tissues, including bone, heart and smooth muscle, secretory cells, platelets, kidneys and osteoblasts. This variation from the norm by and large shows as an expanded resting centralization of intracellular Ca2+ ([Ca2+]I), diminished Ca2+ transporter movement and diminished boost that produces Ca2+ signals. Ca2+ flagging issue are likewise found in neuron-sensory from trial creatures with diabetes.",signatures:"Shahdevi Kurniawan",downloadPdfUrl:"/chapter/pdf-download/71381",previewPdfUrl:"/chapter/pdf-preview/71381",authors:[{id:"316713",title:"Ph.D.",name:"Shahdevi",surname:"Kurniawan",slug:"shahdevi-kurniawan",fullName:"Shahdevi Kurniawan"}],corrections:null},{id:"69739",title:"Hyponatremia and Psychiatric Diseases",doi:"10.5772/intechopen.90011",slug:"hyponatremia-and-psychiatric-diseases",totalDownloads:819,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Eating disorders, psychotic illnesses, and substance use disorders are some of the more common psychiatric conditions encountered in clinical practice that are associated with hyponatremia. The mechanisms that lead to hyponatremia vary, and at times hyponatremia may be a result of a drug side effect or drug-drug interaction. Additionally, hyponatremia from a non-psychiatric condition may lead to psychiatric symptomatology. Given the potential for hyponatremia to cause significant morbidity and potential mortality, clinicians are urged to consider screening for plasma sodium in patients at risk of hyponatremia, such as patients in the three categories of psychiatric conditions described above. Treatment of hyponatremia consists of various acute interventions, with consideration that treatment of the underlying psychiatric condition may help to diminish or eliminate the frequency of hyponatremic episodes in the long run.",signatures:"Ermal Bojdani, Flavia De Souza, Aishwarya Rajagopalan, Anderson Chen, Alesia A. Cloutier, Troy R. Nold and Dil Tahera",downloadPdfUrl:"/chapter/pdf-download/69739",previewPdfUrl:"/chapter/pdf-preview/69739",authors:[{id:"307163",title:"Dr.",name:"Ermal",surname:"Bojdani",slug:"ermal-bojdani",fullName:"Ermal Bojdani"},{id:"310880",title:"Dr.",name:"Flavia",surname:"De Souza",slug:"flavia-de-souza",fullName:"Flavia De Souza"},{id:"310881",title:"Dr.",name:"Aishwarya",surname:"Rajagopalan",slug:"aishwarya-rajagopalan",fullName:"Aishwarya Rajagopalan"},{id:"310882",title:"Dr.",name:"Troy R.",surname:"Nold",slug:"troy-r.-nold",fullName:"Troy R. Nold"},{id:"310883",title:"Dr.",name:"Anderson",surname:"Chen",slug:"anderson-chen",fullName:"Anderson Chen"},{id:"310884",title:"Dr.",name:"Alesia A.",surname:"Cloutier",slug:"alesia-a.-cloutier",fullName:"Alesia A. Cloutier"},{id:"312892",title:"Dr.",name:"Dil",surname:"Tahera",slug:"dil-tahera",fullName:"Dil Tahera"}],corrections:null},{id:"71787",title:"Effect of Foot Morphology and Anthropometry on Bipedal Postural Balance",doi:"10.5772/intechopen.92149",slug:"effect-of-foot-morphology-and-anthropometry-on-bipedal-postural-balance",totalDownloads:604,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Maintenance of accurate postural balance is imperative to avoid falls and incapacities especially in overweight and older population. Normal postural balance is affected by various factors like age, gender, body characteristics like lean muscle mass, soft tissue mass, stature, foot anthropometry, etc. A cross-sectional study was conducted among 1000 young population of north Karnataka in which human stature, weight, body mass index, foot anthropometric parameters, etc. along with postural sway were measured. The correlation of these parameters with human stature, weight and postural sway was studied. Data obtained were tabulated, graphically represented and statistically analyzed. Correlation coefficient was formulated for each variable. Foot length and width showed positive significant correlation with height, weight and other variables. Study observations were compared with those obtained from previous studies. The study observations will enable us to understand the influence of foot anthropometry on postural balance and help researchers to formulate weight transfer strategies, thereby facilitating management and rehabilitation of patients with postural instability.",signatures:"Charmode Sundip Hemant",downloadPdfUrl:"/chapter/pdf-download/71787",previewPdfUrl:"/chapter/pdf-preview/71787",authors:[{id:"314616",title:"Dr.",name:"Charmode Sundip",surname:"Hemant",slug:"charmode-sundip-hemant",fullName:"Charmode Sundip Hemant"}],corrections:null},{id:"71985",title:"Discretion or Disorder? The Impact of Weight Management Issues on the Diagnosis and Treatment of Disordered Eating and Clinical Eating Disorders",doi:"10.5772/intechopen.92152",slug:"discretion-or-disorder-the-impact-of-weight-management-issues-on-the-diagnosis-and-treatment-of-diso",totalDownloads:617,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Eating disorders, the most lethal of all the psychiatric disorders, are frequently misdiagnosed as benign weight management problems, which contribute to their being underdiagnosed and under-reported. Though eating disorders are typically first identified through easily discernible weight change, their unseen origins lie in genetic propensities, neurobiology, environmental and family influences, inborn temperament, and trauma. Non-integrative, behaviorally based weight management solutions that call for dieting and meal plans alone, by ignoring the psychological underpinnings and neurobiological origins of dysfunctions driving these disorders, can potentially lead to loss of life and/or life quality. Conversely, generic psychotherapy protocols typically fail to address and enforce the behavioral prerequisite to re-feed the malnourished eating disordered brain and body, which is required to optimize therapy outcomes. It is for the intuitive and skillful diagnostician to determine whether the patient’s desire for weight change is based on healthful autonomous discretion or on the dictates of compulsions based in life-threatening pathology, thus informing treatment. Eating disorders are disorders of the core Self of self-regulation, self-perception, self-esteem and self-care, affecting life spheres far exceeding eating-lifestyle and weight management. Healing weight management problems requires integrative diagnosis and care, re-establishing one’s healthy relationship with food, weight, and eating, as well as with one’s re-integrated core self.",signatures:"Abigail H. Natenshon",downloadPdfUrl:"/chapter/pdf-download/71985",previewPdfUrl:"/chapter/pdf-preview/71985",authors:[{id:"186482",title:"M.A.",name:"Abigail H.",surname:"Natenshon",slug:"abigail-h.-natenshon",fullName:"Abigail H. Natenshon"}],corrections:null},{id:"70972",title:"Warming in Anorexia Nervosa: A Review",doi:"10.5772/intechopen.90353",slug:"warming-in-anorexia-nervosa-a-review",totalDownloads:695,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Anorexia nervosa (AN) is a severe psychiatric condition primarily affecting young women, and AN has the highest mortality rate among psychiatric disorders. AN continues to be a disorder refractory to psychological or pharmacological treatment. An innovative approach arises from research in rats simultaneously placed on a restricted feeding schedule and given free access to an activity wheel. The detrimental effects of combining diet and exercise in rats can be reversed by a manipulation of ambient temperature (AT). Warming animals exposed to these experimental arrangements reverses running activity, preserves food intake, and enables rats to recover from acute weight loss. This represents a strong preclinical evidence that provides a rationale for a translational approach for the treatment of AN. However, heat application to AN patients was already a recommendation made by William Gull in his seminal paper on AN disorder. A historical perspective of supplying heat to AN patients reviews the circumstances and foundation of this practice. The manipulation of AT in activity-based anorexia (ABA) rats has ended with a period of neglect of AT that parallels the complete neglect of the role of AT in the human AN disorder, either as a risk factor, as a modulating factor in the course of the disorder, or in terms of its utility in the treatment of AN.",signatures:"Emilio Gutiérrez and Olaia Carrera",downloadPdfUrl:"/chapter/pdf-download/70972",previewPdfUrl:"/chapter/pdf-preview/70972",authors:[{id:"312907",title:"Prof.",name:"Emilio",surname:"Gutiérrez",slug:"emilio-gutierrez",fullName:"Emilio Gutiérrez"},{id:"314346",title:"BSc.",name:"Olaia",surname:"Carrera",slug:"olaia-carrera",fullName:"Olaia Carrera"}],corrections:null},{id:"72173",title:"A Software-Assisted Qualitative Study on the Use of Music in People with Anorexia Nervosa",doi:"10.5772/intechopen.92589",slug:"a-software-assisted-qualitative-study-on-the-use-of-music-in-people-with-anorexia-nervosa",totalDownloads:626,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Anorexia nervosa (AN) is an eating disorder associated with a high mortality and an often chronic and disabling course. Thus, novel treatment options should be explored. We performed two focus groups with a total of six people with AN on their use of music and their thoughts about music as an additional therapeutic option. Interviews were transcribed and analyzed in-depth using the NVivo 12 software package. The most prevalent theme throughout the focus groups involved positive expressions, emotions and memories related to music. This theme occurred in ~25% of the data. The importance of music was the second most common theme. Negative feelings and memories associated with music accounted for only ~10% of all references. All six patients expressed that they see benefit in using music therapy as an adjunct to their current treatment. Our analysis shows that people with AN connect music mainly with positive emotions and memories. Therapists might think about applying music more frequently during their sessions with AN patients and consider adding music therapy to their overall treatment concept. However, the results also suggest that music can influence mood not only positively but negatively as well. Quantitative research in bigger patient samples and randomized clinical trials will be necessary to verify these results.",signatures:"Briana Applewhite, Aishwarya Krishna Priya, Valentina Cardi and Hubertus Himmerich",downloadPdfUrl:"/chapter/pdf-download/72173",previewPdfUrl:"/chapter/pdf-preview/72173",authors:[{id:"231568",title:"Dr.",name:"Hubertus",surname:"Himmerich",slug:"hubertus-himmerich",fullName:"Hubertus Himmerich"},{id:"317826",title:"Dr.",name:"Briana",surname:"Applewhite",slug:"briana-applewhite",fullName:"Briana Applewhite"},{id:"317827",title:"Dr.",name:"Aishwarya Krishna",surname:"Priya",slug:"aishwarya-krishna-priya",fullName:"Aishwarya Krishna Priya"},{id:"317828",title:"Dr.",name:"Valentina",surname:"Cardi",slug:"valentina-cardi",fullName:"Valentina Cardi"}],corrections:null},{id:"72328",title:"Evidence-Based and Novel Psychological Therapies for People with Anorexia Nervosa",doi:"10.5772/intechopen.92680",slug:"evidence-based-and-novel-psychological-therapies-for-people-with-anorexia-nervosa",totalDownloads:926,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Anorexia nervosa (AN) is a serious and often highly persistent psychiatric disorder, whereby sufferers struggle to maintain a healthy weight. Its complexity creates challenges regarding treatment, however psychological therapy is recommended by the National Institute for Heath and Care Excellence (NICE). There are four major evidence-based psychotherapies recommended for treating adults – enhanced cognitive behavioural therapy (CBT-E), the Maudsley model of anorexia nervosa treatment for adults (MANTRA), specialist supportive clinical management (SSCM) and focal psychodynamic therapy (FPT)—and three main psychotherapies recommended for treating adolescents with anorexia-family therapy for anorexia nervosa (FT-AN), enhanced cognitive behavioural therapy (CBT-E) and adolescent focused therapy for anorexia nervosa (AFP-AN). Additionally, several novel adjunct treatments are under examination, two of which—cognitive remediation therapy (CRT) and cognitive remediation and emotion skills training (CREST)—are also discussed in this chapter. Other relevant areas regarding psychological treatment include: combinations of medication or occupational therapy and psychotherapy, treating individuals with comorbidities, the challenges of studying psychological treatment for anorexia and future directions of psychotherapies for anorexia, and are also discussed.",signatures:"Anna Carr, Kate Tchanturia, Emmanuelle Dufour, Mary Cowan and Hubertus Himmerich",downloadPdfUrl:"/chapter/pdf-download/72328",previewPdfUrl:"/chapter/pdf-preview/72328",authors:[{id:"231568",title:"Dr.",name:"Hubertus",surname:"Himmerich",slug:"hubertus-himmerich",fullName:"Hubertus Himmerich"},{id:"317829",title:"Dr.",name:"Anna",surname:"Carr",slug:"anna-carr",fullName:"Anna Carr"},{id:"317831",title:"Dr.",name:"Mary",surname:"Cowan",slug:"mary-cowan",fullName:"Mary Cowan"},{id:"317832",title:"Dr.",name:"Kate",surname:"Tchanturia",slug:"kate-tchanturia",fullName:"Kate Tchanturia"},{id:"320604",title:"Ms.",name:"Emmanuelle",surname:"Dufour",slug:"emmanuelle-dufour",fullName:"Emmanuelle Dufour"}],corrections:null},{id:"71394",title:"Anti-Obesity Medical Devices",doi:"10.5772/intechopen.91697",slug:"anti-obesity-medical-devices",totalDownloads:658,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Obesity is a major health problem worldwide responsible for increased morbidity/mortality and high cost for the society. Management of obesity requires multidisciplinary approaches including diet, food supplement, exercise, behavior change, drug, medical device, gut microbiome manipulation, and surgery. Anti-obesity medical devices are an option for subjects who have not responded to more conservative medical treatments but want an alternative to surgery. Compared to bariatric surgery, they have the advantage of being less invasive, easier to perform, and reversible. In the United States of America (USA), based on the expected weight loss, the Center for Devices and Radiological Health (CDRH) of the Food and Drug Administration (FDA) categorizes anti-obesity medical devices as weight-loss devices or weight-management devices. The weight-loss devices include gastric band devices, gastric space-occupying devices, and gastric emptying devices. The weight-management devices include oral removable palatal space-occupying devices and ingested transient gastric space-occupying devices. The effectiveness, safety, and cost of anti-obesity medical devices vary considerably by the type of medical device. Their use should always be combined with lifestyle changes. Considering the large market size of obesity treatment, anti-obesity medical devices can play a major role in the management of obesity.",signatures:"Hassan M. Heshmati",downloadPdfUrl:"/chapter/pdf-download/71394",previewPdfUrl:"/chapter/pdf-preview/71394",authors:[{id:"313921",title:"Dr.",name:"Hassan M.",surname:"Heshmati",slug:"hassan-m.-heshmati",fullName:"Hassan M. Heshmati"}],corrections:null},{id:"71736",title:"Gut Microbiome in Obesity Management",doi:"10.5772/intechopen.91974",slug:"gut-microbiome-in-obesity-management",totalDownloads:621,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Obesity is a worldwide pandemic causing increased morbidity/mortality and high cost for the society. Management of obesity requires multidisciplinary approaches including diet, food supplement, exercise, behavior change, drug, medical device, gut microbiome manipulation, and surgery. Over the past two decades, there has been a growing awareness of the importance of gut microbiome in human health and disease. Profound changes affecting the diversity and the abundance of gut microbiome are associated with several disorders including obesity. A decrease in microbiome diversity and an increase in the ratio of Firmicutes-to-Bacteroidetes phyla have been reported in obese subjects. The gut microbiome can be manipulated to change the host metabolism and manage obesity. Potential interventions include diet (e.g., low calories, low fat, and high fiber), prebiotics (e.g., inulin, lactulose, and resistant starch), probiotics (e.g., yogurt, cheese, and milk), synbiotics (combination of prebiotics and probiotics), bariatric surgery (e.g., Roux-en-Y gastric bypass), and fecal microbiota transplantation (through colonoscopy, esophagogastroduodenoscopy, orogastric tube, or oral capsule). A better understanding of the interactions between different diets and gut microbiome should help the development of new guidelines for the prevention and management of obesity.",signatures:"Hassan M. Heshmati",downloadPdfUrl:"/chapter/pdf-download/71736",previewPdfUrl:"/chapter/pdf-preview/71736",authors:[{id:"313921",title:"Dr.",name:"Hassan M.",surname:"Heshmati",slug:"hassan-m.-heshmati",fullName:"Hassan M. Heshmati"}],corrections:null},{id:"71027",title:"Beneficial Effects of Proanthocyanidins on Intestinal Permeability and Its Relationship with Inflammation",doi:"10.5772/intechopen.91212",slug:"beneficial-effects-of-proanthocyanidins-on-intestinal-permeability-and-its-relationship-with-inflamm",totalDownloads:799,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The intestinal barrier is constantly exposed to potentially harmful environmental factors including food components and bacterial endotoxins. When the intestinal barrier function and immune homeostasis are compromised, inflammatory conditions may be developed and impact overall health. Evidence from experimental animal and cell-culture studies suggests that exposure of intestinal mucosa to proanthocyanidin-rich plant products may contribute to maintain the barrier function and to ameliorate the inflammation present in prevalent pathologies such as diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of altered intestinal permeability and in humans, emphasizing the beneficial effects of grape-seed proanthocyanidin extracts in intestinal health and giving insights into the subjacent biochemical and molecular mechanism.",signatures:"Carlos González-Quilen, Esther Rodríguez-Gallego, Raúl Beltrán-Debón, Montserrat Pinent, Anna Ardévol, Maria Teresa Blay and Ximena Terra",downloadPdfUrl:"/chapter/pdf-download/71027",previewPdfUrl:"/chapter/pdf-preview/71027",authors:[{id:"315872",title:"Dr.",name:"Ximena",surname:"Terra",slug:"ximena-terra",fullName:"Ximena Terra"},{id:"317550",title:"BSc.",name:"Carlos",surname:"González-Quilen",slug:"carlos-gonzalez-quilen",fullName:"Carlos González-Quilen"},{id:"317554",title:"Dr.",name:"Esther",surname:"Rodríguez-Gallego",slug:"esther-rodriguez-gallego",fullName:"Esther Rodríguez-Gallego"},{id:"317555",title:"Dr.",name:"Raúl",surname:"Beltrán-Debón",slug:"raul-beltran-debon",fullName:"Raúl Beltrán-Debón"},{id:"317556",title:"Dr.",name:"Montserrat",surname:"Pinent",slug:"montserrat-pinent",fullName:"Montserrat Pinent"},{id:"317557",title:"Dr.",name:"Anna",surname:"Ardévol",slug:"anna-ardevol",fullName:"Anna Ardévol"},{id:"317558",title:"Dr.",name:"Maria Teresa",surname:"Blay",slug:"maria-teresa-blay",fullName:"Maria Teresa Blay"}],corrections:null},{id:"72790",title:"Artificial Sweeteners",doi:"10.5772/intechopen.93199",slug:"artificial-sweeteners",totalDownloads:558,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Nowadays, sugar*free food is very popular because of its low calorie value. So food industries make use of various artificial sweeteners of low calorie as an alternative to high calorie sugars and they provide low glycemic response. The U.S. Food and Drug Administration has approved artificial sweeteners such as saccharin, acesulfame-K, sucralose, aspartame, etc. as per acceptable daily intake value (ADI) value, but these artificial sweeteners that breakdown products during metabolism in turn are known to have health and metabolic effects. Hence, in this work, we will discuss about artificial sweeteners, types, and their metabolic and health effects.",signatures:"Kanagamani Krishnasamy",downloadPdfUrl:"/chapter/pdf-download/72790",previewPdfUrl:"/chapter/pdf-preview/72790",authors:[{id:"309960",title:"Dr.",name:"Kanagamani",surname:"Krishnasamy",slug:"kanagamani-krishnasamy",fullName:"Kanagamani Krishnasamy"}],corrections:null},{id:"71716",title:"Long-Term Weight Loss Maintenance",doi:"10.5772/intechopen.92103",slug:"long-term-weight-loss-maintenance",totalDownloads:717,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Weight maintenance can be considered a challenge for all patients who are in a reduced obese state. In this chapter, we first provide an overview of the chances for maintaining weight loss, how physiological adaptations and psychological dynamics lead to weight regain in the long-term, and of the factors that have been associated with long-term success. Then we review what is known about the patient perspective on that critical time period following weight loss, focusing on the experience of barriers and facilitators as well as attempted strategies. Finally, we introduce an approach for providing a targeted and individualized support at this stage.",signatures:"Martin Fischer, Nadine Oberänder and Arved Weimann",downloadPdfUrl:"/chapter/pdf-download/71716",previewPdfUrl:"/chapter/pdf-preview/71716",authors:[{id:"313764",title:"Dr.",name:"Martin",surname:"Fischer",slug:"martin-fischer",fullName:"Martin Fischer"},{id:"313765",title:"Prof.",name:"Arved",surname:"Weimann",slug:"arved-weimann",fullName:"Arved Weimann"},{id:"319867",title:"Dr.",name:"Nadine",surname:"Oberänder",slug:"nadine-oberander",fullName:"Nadine Oberänder"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7885",title:"Anorexia and Bulimia Nervosa",subtitle:null,isOpenForSubmission:!1,hash:"33446a27725d6ca6f66b4bddb2de4b64",slug:"anorexia-and-bulimia-nervosa",bookSignature:"Hubertus Himmerich and Ignacio Jáuregui Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/7885.jpg",editedByType:"Edited by",editors:[{id:"231568",title:"Dr.",name:"Hubertus",surname:"Himmerich",slug:"hubertus-himmerich",fullName:"Hubertus Himmerich"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"510",title:"Anxiety Disorders",subtitle:null,isOpenForSubmission:!1,hash:"183445801a9be3bfbce31fe9752ad3db",slug:"anxiety-disorders",bookSignature:"Vladimir Kalinin",coverURL:"https://cdn.intechopen.com/books/images_new/510.jpg",editedByType:"Edited by",editors:[{id:"31572",title:null,name:"Vladimir V.",surname:"Kalinin",slug:"vladimir-v.-kalinin",fullName:"Vladimir V. 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and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Associate Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316535",title:"Associate Prof.",name:"Maya Puspa",middleName:null,surname:"Rahman",fullName:"Maya Puspa Rahman",slug:"maya-puspa-rahman",email:"mayapuspa@iium.edu.my",position:null,institution:null}]}},chapter:{id:"72452",slug:"has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-decades-",signatures:"Maya Puspa Rahman",dateSubmitted:"December 9th 2019",dateReviewed:"March 21st 2020",datePrePublished:"June 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Road traffic injuries are, according to the WHO report on the topic, the leading causes of death worldwide. Over 1.2 million of individuals died each year on the road [1]. “Road traffic injuries (RTI) are on increasing in developing countries. Healthcare facilities are poorly equipped to provide the needed services.” [2]. Efforts are made over the past years to improve the emergency care services delivery in the developing countries. Emergency services policies and training programs for emergency providers have been implemented, though, these programs are still facing challenges in the training [3]. The developing countries are facing further challenges beyond the weak training. However, developing countries lack medical transport system. In 2002, Razzak and Kellermann carried out a study [4] and found out that the lack of medical transport is a common issue facing the most of healthcare systems in the developing world; the authors, further, state that ”The provision of timely treatment during life-threatening emergencies is not a priority for many health systems in developing countries.”
Previous works conducted in 2016 and 2017 in the sub-Saharan African countries have revealed that most healthcare systems have partially improved the medical transport issues by acquiring a few numbers of ambulances. However, this fact does not completely meet the issues facing the emergency transportation. The roads are in bad state and though lead to massive time-wasting, with the high risk of medical complication or death.
In [5, 6, 7], the authors have found out that electronic medical records (EMR) have the potential to “improve the delivery of healthcare services” [5] and especially “to improve emergency care in low- and middle-income countries” [7]. However, the global healthcare system is keeping used analog (paper-based) medical records, especially that this is the order in the majority of healthcare systems of low- and middle-income countries [6, 7, 8], while the healthcare systems in the high-income countries are slowly adopting the digital medical record systems [5, 6].
According to the “The Free Dictionary,” emergency medical care (EMC) is defined as
The common generic scenario in MEC is to transport an injured person from an accident place to the emergency services (commonly called emergency room) at a hospital, where he will be intensively treated. The emergency doctor in charge to transport the injured person to the close emergency care center is requested to stabilize him in providing life-saving first treatment during the transport. The emergency doctor (ED) needs patient-centric information for the primary care during the transport and has to timely provide the emergency center with the collected data and information about provided treatment and his diagnostics. Diagnostics made remotely based on patient-centered information provided through the emergency call need to be confirmed or revised once the injured person reaches the emergency center or the ED arrives at the accident place. As Schneider et al. stated in [9], a patient at an emergency room gets screened to confirm or revise the first diagnostics:
Beyond this, the EP is considered as the manager with the mission to evaluate the life-threatening situation that the patient is facing. These operations request accurate data that are in the best case patient-centric and patient-centered. Accessing these data can be time-consuming; therefore, the EP and whole nursing staff need to be assisted by modern technologies to gain time and quickly efficiently provide the first life-saving care to the patient within the golden hour. The golden time, critical where one can lose the injured, is the first hour between the accident occurs and the time the injured receives the first aid. In certain cases, the golden hour is less than 60 min. In this golden time, the emergency has to prevent the injured from any life-threatening medical issues.
Modern information and communication and data security technologies can contribute to collect, process, and store important data and quickly retrieve these data in the case of emergency as well as assure data security. Wireless sensor networks (WSNs) especially the wireless body area network (WBAN) are technologies that can help to collect and ensure data.
The chapter presents a concept for improving emergency medical care process and services delivery in the developing countries. It further pursues the objectives to connect the unconnected health things to enable patient-centric emergency medical care delivery using the Internet of Things paradigm. Data security, communication protocols, and technologies are out of the scope of this chapter. There are various previous works such as [11] that have already covered the EHR access control.
The remainder of this chapter is structured as follows: (i) Section 2 presents the state of the art (literature review) regarding the usage of the Internet of Things in medical application and especially in the emergency medical care. The research objectives and context are presented in Section 3. The technical background is briefly presented in Section 4. The concept and architecture are described in Section 5. The proof of concept (experiment) is presented in Section 6. The test results are discussed in Section 7. Section 8 concludes the chapter.
This section provides a short but comprehensive literature review on the use of the Internet of Things in medical applications like remote medical monitoring using various modern technologies such the wireless technology. It further investigates the state of the art on the use of the Internet of Things in delivering emergency medical care and the patient-centric medical care delivery.
The wireless sensor networks (WSNs) are being used by the healthcare industries to measure patient’s vital parameter through medical sensors that are attached to his body. Bio-signals like body temperature, blood pressure, pulse oximetry, ECG, and breathing activity are, thus, sensed. Further, remote medical centers use end-point devices like video and audio devices to perform advance patient’s monitoring [12].
In a multi-tier WSN, tasks are assigned to different nodes, where certain nodes (e.g., sensors) are assigned to simple tasks with low energy consumption. Low energy consuming nodes last for a long time and best fit for sensing data in healthcare applications. Multi-tier architectures have been used in similar applications like SensEye [13] and IrisNet [14] and have proven to be efficient. Moghadam et al. develop in [15] “an energy efficient data transmission technique for communication between a single-antenna medical sensor/microrobot inside the body to multi-antenna receiver on the body surface though non-homogeneous propagation environment.”
Sensing data from the human body and transmitting over multiple spatial and temporal scales remain the first critical challenges in advanced health informatics [16]. In [17, 18] a noninvasive in vivo glucose sensors for measuring the blood glucose level was developed. In [19], the authors proposed a platform that combines IoT end-point devices (e. g. wearable sensors) with in-home healthcare services to improve user experience and service efficiency.
M. Mazhar Rathore et al. have discussed the presence of the Internet of Things in the medical sector and the amount of data these systems produce [20]. The wireless body area network (WBAN), a subset of the wireless sensor networks (WSNs), is using in the healthcare’s applications to monitor the patient bio-signal [21].
In a previous article, the author presents a wireless sensor network system used at a cardiologic intensive care unit (CICU) to monitor the cardiologic in-patient and the ambient air in the hospital rooms. The patients are attached to a WSN that collect in real time the patients’ vital parameters [22]. The experiment described in [22] has demonstrated that the WSN systems show a promise in collecting and retrieving medical data.
The Internet of Things (IoT) especially the Internet of Health Things (IoHT) presents various potentialities for enhancing the emergency medical care from the beginning of the process till to the admission of the patient at the emergency room.
The emergency operation begins with the first call at the emergency coordination station. At this stage, the call center personal collects under time pressure important information on the occurrence. Most callers are, however, not able to correctly report the event and give information about the exact place of the event. In [23] the contributors proposed an IoT-based smart technology that can overcome the challenges facing the emergency call by automatically provide additional data. The data could be embedded the patient data in the emergency call. Such a system will enhance the emergency response and save time as well as reduce the death rate. In [24], the authors present a comprehensive survey on the usage of IoT in the medical field. Systems to handle the emergency medical care regarding the use of semantics and ontologies in sharing a large amount of medical data as well as data analysis have been described. The survey also presents the so-called indirect emergency health care that aims to assure data availability. Data availability requires data collection at a previous stage. This can happen through the medical record. The survey further discusses a medical record system that enables remote medical advice. It recommends reading the given paper to get more insight into the state of the art on the use of IoT in the health care.
The IoT is facing various challenges such as interoperability, security, authenticity, etc., because of the diversity of objects that can be involved in an IoT system as well as the size of the network that can issue security challenges. In [24], the authors present in an experiment a concept to meet the interoperability challenges in IoT systems. Interoperability can represent a barrier and especially an important issue in the emergency care. IoT system for emergency cases in China is presented in [25]. The authors describe an IoT-based system to monitor blood donation. This system can also help to set personal medical files. A remote monitoring and management platform of healthcare information, similar to that described in [22], is described in [26]. This system shows the potential of using the WSNs (IoT) in the health care. Various advantages of using IoT in the health care are described in [27]. The authors present an interesting aspect “The Anti-counterfeit of Medical Equipment and Medication.”
As discussed earlier, the emergency response phase is an important phase of the whole process. Errors occurred at this phase can be hardly corrected. It is, therefore, important to avoid errors at this phase. In [28], the authors pose two research hypotheses as follows: (i)
Their findings fit the hypotheses and thus show that using IoT at emergency calling and response processing can enhance the emergency care.
The patient-centered information originates from the patient and is mostly concerning the patient’s needs and preferences regarding his healthcare concerns. It relies on the communication and a good relationship between the patient, patient’s relatives, and the treating personnel. Starfield points out in [30] that patient-centered information or care rests on core elements such as communication or interaction and adherence to the recommendation concerning the care. It is determined by the interaction between patient and medical doctors [31].
The patient-centric information is directly produced by the patient himself added to the data that are mined from the (electronic) medical and/or health records, which in turn must include genomic information, which enables to figure out any disease predisposition.
The modern wireless technologies are used to collect the patient vital parameters as well as to filter clinical document to gain patient-centric data. The use of patient-centric information including genomic data in the emergency care is still not in order. Medical records do not include genomic information yet [32], and only few healthcare professionals are using electronic medical and/or health records [6].
The use of electronic health records (EHR) in the medical care delivery impacts positively the treatment outcomes [31, 32]. In [33] the authors have shown that context-aware data and patient-centric decision-making are vital for personalized healthcare delivery. They discuss the challenges facing these new paradigms in wirelessly collecting physiological data and consequently proposed patient-centric care delivery for ubiquitous health care. The study found out that the proposed patient-centric information “will significantly improve the response time, quality, and relevance of data- and compute-intensive medical applications.”
To our best knowledge, patient-centric-based emergency care delivery is still at an embryonic stage. The comprehensive literature review has shown that only few research works have been done regarding the topic. However, the terms are often mixed up or confused. Earlier articles written on the topic have confused patient-centric with patient-centered information. In [34] one can note this regarding the definition the authors made. This can be the reason why only a few articles handle the topic.
The main objective pursued in this study is to enhance the emergency medical care process from the response operation till to the hospital admission, especially in the developing countries, using IoT to autonomously and automatically provide in real time the emergency healthcare professionals and the emergency care centers with accurate and appropriate patient-centric information and, thus, substantially reduce the death rate.
This study aims at enhancing the data provision and exchange for a data-driven, patient-centric, and patient-centered emergency care.
At the present stage, the study focuses on the improvement of the emergency process in the case of a road accident in the developing countries. The developing countries and the road traffic injury represent therefore the research context of the study. The main reason for this choice is (i) the several healthcare access issues people are facing, (ii) the challenges the emergency transportation is facing, (iii) the lack of information and communications technology infrastructure, and the information paucity in the medical sector. The developed countries will also be considered. For evaluation purposes, cohorts of participants were built to simulate, test, and evaluate the different systems proposed. In collaboration with involved clinics and hospitals, we recruit patients using snowball approach. Each involved individual gives his consent so that their data can be collected, processed, and stored. The data were anonymously collected, processed, and stored. We also apply for ethical approval at the involved hospitals and clinics as well as at local municipal authorities.
Internet of Health Things (IoHT) integrates health objects with network connectivity from the digital and physical world. Furthermore, it combines personal health technologies and IoT and takes full advantages of IoT in expanding abilities to exchange useful data and enable improvements in context awareness and the ability to initiate actions based on data that are collected and analyzed [35].
Device-to-device (D2D) communication enables devices to communicate directly without interaction of base stations or access point. It is intended to exchange data utilizing various technologies such as ultrawideband (UWB), near-field communications (NFC), Zigbee, Bluetooth, Wi-Fi Direct, or LTE Direct. The distance between the devices is relatively short and defined by the using protocol. The communication is technology dependent [36].
M2M is an autonomous communication, based on a cellular network such as GSM, LTE, etc., where the communication passes through core networks via base stations or access points and M2M Server (application server). Compared with D2D, the communication is not direct and does not matter if the devices are approximate to one other. The distance between the devices is unlimited. Furthermore, the M2M communication is application oriented and technology independent (interoperability) [36].
WSN refers to a group of spatially dispersed and dedicated sensors for monitoring and recording the physical conditions of the environment and organizing the collected data at a central location. Sensors, within the network, sense and process data and communicate with each other [7]. WSNs are intended for efficient and cost-effective medical monitoring/surveillance for deployment at emergency medical care centers so that health professionals can easily monitor their in-patients irrespective of location and time and thus collect important bio-signals and environmental data for an effective treatment.
Crowdsensing is a critical component of the Internet of Things [37]. Crowdsourced data can be collected using participatory or opportunistic crowdsensing paradigms, where participants’ smartphone sensors are used to collect information/data. Smartphone sensors or sensor systems are increasingly used for measuring the quality of ambient air [38] and temperature and particularly sensing bio-signals within an in- or outdoor crowd.
Crowdsensing systems are either participatory or opportunistic. Participatory crowdsensing requires participants’ active involvement: participants perform computations and generate data as inputs for the systems, while in opportunistic crowdsensing requires fewer participants’ involvement: sensing is more autonomous, data are automatically generated without user involvement, and computations are also automatically performed using participants’ devices or available sensors [39].
This section describes the proposed IoT-based patient-centric information processing system for improving the global emergency medical care services delivery and especially equipping the developing countries’ emergency medical care systems with an adapted and context-sensitive emergency medical care system.
A distributed and federated medical record that includes information like genomic information as designed and implemented in [6] is the central piece of the proposed patient-centric information system that uses the IoT paradigm to collect, store, and process data. The EMR is accessible to any emergency doctor during an emergency transportation. The EMR features components like emergency cases relating to information, medical case files, and genomic files including disease predisposition information.
Additionally, a crowdsensing-based road traffic congestion detection unit is featured and contributes to early detect road traffic congestion and consequently compute an alternative route to quickly attend the emergency center closer to the accident place.
The emergency calling disposes an IoT-based calling system capable to embed the injured person’s emergency data, data of place of the occurrence, geographical data, and personal data of the caller in emergency response that will be forwarded to emergency doctor and emergency transportation unit.
Wireless sensor network technology is used to collect patient-centric data and timely update the EMR. Furthermore, the proposed should enable to autonomously, automatically, and contactlessly exchange data with the information desk at the emergency care hospital and any computer networking wireless devices that can ad hoc be registered and connected to the ambulatory emergency care information system for providing or collecting data.
The communication between the proposed system and the information desk as well as any wireless (mobile) devices will follow the D2D and/or M2M communication paradigms. The communication within the system is based on M2M communication paradigm to prevent the interoperability issues and to enable the machines (physical or logical) to use different communication technologies and protocols to easily communicate with each other.
The emergency transportation system in the most developing countries is inadequate. The road traffic net is in a bad state, and medical helicopter does not exist. A real-time road traffic congestion detection is, therefore, so important to prevent any delay in emergency transportation. Developed countries also face road congestion at the pick hours or by an accident event. The proposed crowdsensing-based road traffic congestion detection system can be adapted and thus used in the developed countries too (reverse innovation). Over the past years, many efforts in monitoring the road traffic to prevent road traffic congestion and accident are done. The IoT vehicle-to-vehicle (V2V) technology is used to implement such systems. Various research works were and are still being conducted on the topic (see [40, 41, 42, 43, 44, 45, 46]). Implementing such system in the developing countries is easier than in the developed countries since personal data protection or data privacy act is less restrictive in the developing world. Alternative solution approaches based on inter-vehicular communication with respect to the data privacy and security have been discussed in [42, 47].
The proposed congestion detection system takes into account the technological level, the ICT, and municipal infrastructure available in the developing world. Technologies like inter-vehicular communication, vehicle-to-vehicle (V2V) communication, infrastructure-to-infrastructure (I2I) communication are not implementable in these countries, though crowdsensing paradigm can be implemented since smartphones with embedded cameras are available and the regions are well covered by mobile telecommunication infrastructure. The requirements for a standard crowdsensing are met here, and thus the proposed road traffic congestion detection system can be implemented here. The system aims at combining both participatory and real-time opportunistic crowdsensing and crowdsourcing data to energy-efficiently and low-cost monitor ad hoc traffic crowds for early detection of traffic jam risks.
A cloud-based algorithm requests continuously participant’s mobile phone on given routes to provide information on the traffic. These participants are requested to activate the client application installed on their mobile phones to participate in the traffic monitoring. The client application measures the density of the traffic in reporting their GSP coordinates to the cloud. The client could recognize which GSP coordinates are useful for detecting a traffic congestion.
The proposed detection system aims at detecting the congestion at a crossroad as well as measure the congestion length. Each traffic light has GSP coordinates. The detection’s algorithm monitors every activity within 2 kilometers around the traffic light using all smartphone coordinates in this circle. Thus, the speed of each vehicle or motorcycle on the given route can be determined, and, thus, traffic jam can be detected if it occurs. Similar work has been conducted and presented in [42] where the authors use the vehicle-to-vehicle paradigm to detect traffic congestion. Li Wei et al. propose in [48] a real-time road congestion detection in estimating vehicle density based on texture analysis and evaluate the system. The results demonstrate the potentiality of this approach.
As Zhu et al. in [49], the traffic is categorized, after an observational study, in peak and flat period. From 10 pm to 4 am the next day, we have a flat traffic. From 5 am to 9 am, the road congestion is high as well as the accident risk. Between 7 pm and 9 pm, road congestion can again be noted. The algorithm considers all this information in searching the appropriate route. This algorithm also uses the travel salesman algorithm in calculating the route for a quick transportation of the patient from the accident place to the next hospital. In [50] a model to optimize a network traffic flow is proposed. The model can be implemented to enable low-delay vehicular traffic flow. The proposed model shows a promise for low-delay vehicular traffic flow control from which emergency transportation can take benefit.
The patient medical record (MR) includes emergency data and medical case files and is a central piece of the concept. The clinical documentation (CD) is a digital or analog record tracking all medical treatment and related activities. MR and CD are part of the hospital information system (HIS). The clinical documentation serves as the basis and benchmark medical information document for further medical activities (e.g., treatment) or investigation on prior treatment; therefore, it must be accurate, must be timely filled, and must prevent any data privacy issues. It further can serve to create complete patient medical records including medical data from different medical institutions.
A hospital information system (HIS) must ensure that the patient medical and health records, as well as the clinical documentation, are always available, reliable, and data privacy assured. Available medical record at anytime and anywhere is an important piece in efficient, effective, and timely emergency care services delivery; beyond the availability aspect, the accuracy and the authenticity of the information/data contained in such document are very important for any further medical activities. The medical record must be up to date and well written (in the case the practitioner likes to write a medical assessment into the record).
The proposed MR (Figure 1) is a federated electronic MR (fEMR) equivalent to an electronic health record (EHR). It lies on a federated database system (FDB) and collects patient’s medical records from all available sources. The so collected data is stored in the central database. An algorithm performs autonomously and automatically this job one to two times a day. An FDB is “a federated database system is a collection of independent, autonomous database systems, each with their own set of global users, which cooperate together to form an alliance or federation that enables global users to access data across the participating systems in a transparent manner.” [51].
Architectural view of the proposed federated electronic medical records.
The fEMR can be connected to WSNs designed and implemented for collecting data within an emergency transportation. Once the emergency call is completed and all needed information is collected, the call center assigns an ambulance and an emergency doctor to the case. The patient’s fEMR is connected to the WSN system in the ambulance. The patient-centric information is then set and can start collecting data emanating from the patient and automatically update the EMR. Accident report unit is featured by the EMR and is filled during the emergency calling phase. The emergency doctor (ED) can add more details to accident report once he is at the accident and collect patient-centered information.
The fEMR system can be used in on- and offline mode. Offline modus is considered for regions where the access to the Internet is limited or nonexistent. The ED can then download a lightweight version of the patient’s fEMR and use it for his purposes. The data added newly to the local copy of the patient’s fEMR will then be synchronized with the cloud-hosted fEMR if the Internet access is again available. A backend routine performs this task automatically.
Patient emergency data (PED) are medical data that are necessary rather mandatory during the golden hours in the case of emergency. It is, for example, vital in a case of emergency to have accurate information on the diabetic condition of an individual or his serologic status or the list of his current medication to prevent any drug intoxication. The emergency data are created automatically set by the EMR system. Any treating physician can add emergency care-relevant information. The emergency data is stored on the patient’s electronic health card as well as in the EMR in the central database.
The emergency data includes the allergies, the medicinal treatments, the medical risks, and the avoidable medical attacks, i.e., any procedures, which are life-threatening for the patient. These data are updated regularly and must be reliable. The emergency data must be always available.
The diagnostics or medical case file includes the picture of a specific illness, the treatments performed, and the course of the illness. This information is purposely created ad hoc to facilitate the decision-making regarding any medical activity concerning the patient.
The architectural view of a standard patient-centric emergency care delivery is illustrated in Figure 2. The proposed standard patient-centric and IoT-based emergency care services delivery system combine collecting vital parameters (on the patient within the transportation) using WBAN/WSN technology with the retrieving health records from the fEMR. The system filters the needed data from these different sources and presents them to the medical doctor. The data collected through the WBAN are automatically processed and stored in the fEMR.
Standard patient-centric emergency care delivery process.
The patient-centered data or information are recorded and stored in the fEMR. A voice-based interface oversees collecting audio information and stores it local and remote.
The call center is featured with an M2M-based system that autonomously embeds the accident data in the patient’s fEMR, sends it automatically to the emergency transportation unit, and determines the geo-position of the accident.
A road traffic congestion unit contributes to finding the right routes to preventing road traffic congestion. This component is specially designed for developing counties since developed countries dispose of adequate road traffic monitoring systems and can use medical helicopters to emergency transportation. As earlier described, this component fits the road nets in the developing countries and is context-aware.
There exists an ICT infrastructure gap between the developing and developed countries [6]. The concept takes, therefore, an account for this fact and proposes an adapted patient-centric and IoT-based emergence care services delivery in the case of road traffic accident. At the rural level, emergency care transportation logistics are scarce or nonexistent. Often, it is very hard to quickly attend those areas due to the bad state of the road. To overcome this challenge, the near dispensary will request a nonmedical car and remotely instruct the driver as well as the rescue caller on how to transport the injured to the next dispensary. Each care is supposed to have a well-equipped pharmacy for the first aid on board. Car drivers are also supposed to be trained to give first aid. At the same time, an ambulance will be requested from the near emergency center. This operation has the potential to save time and provide the first aid to the injured. Imagine, healthcare professionals at a dispensary must go the accident scenes that can be several kilometers far away before the injured will receive the first aid. This scenario can lead to the injured death or cause him/her serious disability. To prevent such a situation, the dispensary personnel will remotely and accordingly instruct the relatives of the injured person with the information from the patient fEMR. The instructions are based on the patient-centric information. Once the injured person is delivered to the dispensary, an ambulance will transport him to the next emergency care center. Figure 3 illustrates an emergency care delivery process at the rural level.
Patient-centric emergency care delivery process when the accident occurs in rural regions.
This section will shortly present the conducted experiment, study methodology, and materials.
The global concept, as well as the appropriate architecture for improving the emergency care delivery, was tested at the rural level. A test cohort was built and an accident scene in a village was simulated. The area was selected according to following criteria: (i) lack of ambulance, (ii) very difficult road accessibility, (iii) the next dispensary is at 30 km, and (iv) mobile phone and telecommunication are possible.
Two car drivers, one with an approved medical first aid training and one without approved medical first aid training, and a less-educated caller are recruited. The reason why we select a less-educated call is to simulate the real situation, where the caller is often confused. The car driver without medical first aid training is selected to test the impact of the training on completing instructions received from a remote healthcare professional.
A dummy fEMR is generated. The accident scene is set up. Three data-driven emergency care delivery scenarios were simulated: (i) a patient-centric emergency care delivery, (ii) a patient-centered emergency care delivery, and (iii) emergency care delivery based on patient-centric combined with patient-centered information. Table 1 indicates the test scenarios and outcomes with their characteristics. The impact of the first aid training on the care delivery is also investigated.
Test scenarios | Characteristics of the car driver | Origin of the information used | ||
---|---|---|---|---|
Approved training | No approved training | Patient-centric information | Patient-centered information | |
Test 1 | x | x | ||
Test 2 | x | x | ||
Test 3 | x | x | ||
Test 4 | x | x | ||
Test 5 | x | x | x | |
Test 6 | x | x | x |
Simulation scenarios for emergency medical care services delivery.
x means which information is used and what is the training level of the car driver involved. For example, Test 1 involves car driver with approved training and used data emanated from the patient (patient-centric information).
A rapid prototype of the proposed system was implemented. The server-side application was hosted on a GlassFish 4.0.1 on a laptop. A client application is used to visualize received data. The client application on the smartphone (gateway, sensors) communicates directly with the server application.
A qualitative data analysis is done using r-data analytics tool and following approaches: (i) organizing the data, (ii) identifying the framework, (iii) sorting the data into the framework, and (iv) using the framework for descriptive analysis.
The car driver with approved training in medical first aid successfully completed his assigned task in accordance with the instructions of the remote healthcare professional, and he has timely delivered the injured to the dispensary without additional damages. However, the other driver, without approved training in medical first aid, was less successful in completing his tasks despite the received instruction.
The experiment that uses patient-centric information has shown that beyond the standard emergency care, personalized care was provided through the information from the fEMR. The simulation with patient-centered information was also successful, but no personalized care was provided. Furthermore, the collected data within the emergency care were locally processed and archived at the emergency center and likely will not be used for further care provision. In contrary, data that were collected within the patient-centric emergency care provision are stored and processed in the cloud and the fEMR is synchronized and up to date. Information about the transportation duration, the quality of the primary care delivery, and the outcomes are collected.
The test’s main objective was to figure out the impact of the medical first aid training on the outcomes and impact of the quality and source of the information on the outcomes.
Worst cases, where car drivers are not up to date regarding the medical first aid training (that means he was trained but forgets the essentials) or furthermore the case where nobody at the accident scene is trained to give medical first aid, are not tested.
The test period is relatively short. Furthermore, real emergency cases were not tested, and then such cases could provide more useful data for analysis.
The car driver with approved training in medical first aid successfully completed his assigned task in accordance with the instructions of the remote healthcare professional, and he has timely delivered the injured to the dispensary without additional damages. However, the other driver, without approved training in medical first aid, was less successful in completing his tasks despite the received instruction.
The experiment that uses patient-centric information has shown that beyond the standard emergency care, personalized care was provided through the information from the fEMR. The simulation with patient-centered information was also successful, but no personalized care was provided. Furthermore, the collected data within the emergency care were locally processed and archived at the emergency center and likely will not be used for further care provision. In contrary, data that were collected within the patient-centric emergency care provision are stored and processed in the cloud and the fEMR is synchronized and up to date.
Table 2 summarizes the test outcomes.
Test | Outcomes |
---|---|
Test 1 | Positive outcomes. The patient received adequate first aid due to the knowledge of the driver and the accurate patient-centric data available |
Test 2 | Negative outcomes. Information provided was incomplete (subject). This has negatively impacted the outcomes. The transportation was conservative, and then the driver knows how to prevent any additional medical or health damages |
Test 3 | Due to lack of first aid, the collected data could not be used in the golden hour. However, the patient received adequate care based on the collected data. The healthcare professionals have estimated that in real case the patient’s chance to survive could be less than 40%, since he did not receive appropriate care in the golden hour and, additionally, the transportation was not conservative because the driver was not trained |
Test 4 | The outcome is similar to Test 3. However, the survival chance for the patient was estimated to 10%, and then the medical examinations were needed to verify the information provided by the patient |
Test 5 | Very positive outcome. All the needed information is available. The patient was stabilized in the golden hour. The transportation to the hospital was conservative. At the hospital, the patient received timely follow-up treatment (simulation). Timely because no medical treatment was needed. The patient-centric data is already available |
Test 6 | The outcomes are similar to those at Test 5. However, the transportation was not conservative, because the driver was not trained |
Test outcomes.
Previous research works have demonstrated that health care is taking enormous benefit of the use of Internet of Things technology and paradigm in the healthcare provision. A comprehensive literature review has revealed that IoT technologies like WBAN and WSN are used for collecting, storing, and processing patient-centric data. The data processing takes a full benefit of the IoT technology, where data are autonomously and automatically collected. Fog/edge computing contributes to locally process with the collected data for quick decision-making. Quick decision-making is an important issue in the healthcare delivery regarding the time that is a critical point.
This study presents an IoT-enabled emergency medical care services delivery system working with patient-centric data (current and previously collected data) from different sources, including genomic data, which is not actually considered in medical treatment due to the high cost of genomic sequencing. The central piece of the proposed system is the federated electronic medical care that collects EMRs from different sources, adds the genomic part, and sets automatically the individual emergency care data as well as medical cases files on demand.
This system has presented a novelty. To our best knowledge, no emergency care system worldwide is using such a federated database like health record.
Author Edoh declares that he has no conflict of interest. Informed consent was obtained from all individual participants included in this study.
All societies, both solid and liquid, produce waste. Wastewater can be considered as a combination of waste produced by water from residential, administrative, commercial, and industrial facilities and drained into groundwater or surface water. Untreated wastewater contains pathogenic microorganisms and organic matter. Degradation of untreated wastewater organic matter produces stinking gases. Therefore, wastewater treatment is one of the essential measures that must be taken before discharge into the environment. Wastewater treatment is a practical solution to speed up the process of providing safe and transparent reusable water.
The pollutants can be removed from wastewater using a variety of ways that are divided into three main categories: physical, chemical, and biological processes. A purification process generally consists of five successive steps as described in Figures 1 and 2: (1) preliminary treatment or pre-treatment (physical and mechanical); (2) primary treatment (physicochemical and chemical); (3) secondary treatment or purification (chemical and biological); (4) tertiary treatment (physical and chemical); and (5) treatment of the sludge formed (supervised tipping, recycling or incineration) [1, 2].
Main processes for the decontamination of industrial wastewaters [
Primary and secondary treatment of sewage [
Physical wastewater treatment is the first step in the treatment of industrial and sanitary effluents, which in addition to increasing the efficiency of other steps, prevents damage to the equipment used in chemical and biological treatment. The equipment and processes used in physical wastewater treatment vary according to the type of effluents and the quality desired for wastewater. In other words, since the wastewaters are mostly very colored and contain high biological and chemical oxygen, they have high electrical conductivity and are considered chemically alkaline. In other words, since the wastewaters are mostly very colored and contain high biological and chemical oxygen, they have high electrical conductivity and are considered chemically alkaline. Accordingly, different parameters affect the cost of selecting a wastewater treatment method. Factors such as the type of pollutants to be treated, the chemical composition of wastewater, the cost of chemicals required, the operating cost, the cost of collecting waste generated by the treatment process, affect selecting a wastewater treatment method [4].
Based on the various processes and steps mentioned for the physical treatment of industrial and sanitary effluents mentioned above, equipment such as the following is required:
Types of garbage (manual, mechanical and even grating)
Settling pools and sludge bridges for collecting deposited sludge
Classifier and a variety of granular to remove fine grains such as sand
In this chapter, we will explain each of the above.
The separation process of particulate matter and solids in industrial and sanitary effluents is called physical purification. Depending on the type of sewage, there may be pieces of fabric, the foliage of trees, sand and plastic parts, etc. in the fluid entering the treatment plants. Entering these particles into wastewater treatment equipment such as pumps, pipes, and fittings may cause damage. In addition, the failure to remove these items causes a lot of pressure on the equipment in chemical and biological wastewater treatment, and their output quality decreases. For this purpose, with practical and simple equipment, physical treatment processes of industrial and sanitary wastewaters are implemented.
Considering the capacity of the treatment plant and the speed of entering fluid, and the size and amount of dissolved and suspended solids in the wastewater, it is necessary to install appropriate littering in the inlet of the sewage canal. The litters used in this step of physical wastewater treatment are varied, and each one has specific features, the most important of which are the following options:
Other types of littering used for large refineries include mechanical garbage collectors. The most important feature of this equipment is that the engine is on top of it. So, after accumulating solid particles in the sewage on the blocker screen, the collection process is done. The mechanical garbage collector is divided into the bar, lattice or lace, strapping, round-trip rod, chain, and cylindrical movement groups in terms of appearance structure. In this type of garbage collector, human resources are not used. It can remove suspended solids up to 2–3 mg. It should be noted that the necessary force for motor movement in mechanical garbage is supplied from electricity and therefore has higher energy consumption than the manual type (Figure 3) [5].
Bar rack and traveling screen [
A handheld screen consisting of several bars is located at certain distances and prevents particles with a size greater than two centimeters from entering the treatment plant. As the name of this equipment is known, after accumulating particles and solid patches on the plate, human operators perform the collection process. Garbage collectors have different types of fine and coarse grain. Due to the lack of electricity, it is cost-effective for the physical treatment of wastewater. It should also be noted that the material used to make the body and screen is resistant to acidic and corrosive materials and has a long lifespan (Figures 4 and 5) [5].
Preliminary Treatment of Sewage [
Bar screen in a detritus tank [
The grating pair is composed of two lattice plates and nets that block the passage of sewage. This type of littering is located in the group of mechanical garbage collectors and without the use of a human operator, the collection of accumulated materials on the plate is done. Due to the use of two lace plates in the overall structure of this screen, its efficiency and efficiency for physical treatment of wastewater and removal of suspended solids are high and with the destruction of one plate, it is possible to continue working with another plate [5].
The garbage collectors are designed based on the diameter of the seeds to be removed, the width and depth of the canal and rods, the distance between the rods, the vertical slope, the speed and the loss of the allowed head.
Table 1 shows some design parameters and criteria for mechanically and hand-cleaned screens.
Parameter | Mechanically cleaned | Manually cleaned |
---|---|---|
Bar Size | ||
Width (mm) | 5–20 | 5–20 |
Thickness (mm) | 20–80 | 20–80 |
Bars cleaner spacing (mm) | 20–50 | 15–80 |
Slope from vertical (degrees) | 30–45 | 0–30 |
Approach velocity (m s−1) | 0.3–0.6 | 0.6–1.0 |
Design parameters and criteria for Bar screens [5].
Industrial and sanitary wastewaters are not completely cleaned of suspended materials despite passing through multiple filters (littering). Many of these small particles will settle on the floor of the treatment plant, depending on their weight if they have the opportunity. The second important process in the physical treatment of industrial and sanitary wastewaters is to allocate time for settling suspended materials in special pools. By doing so, largely fine and particulate matter is transferred to the bottom of the pool and gradually converted into sludge, which will be periodically drained (Figure 6) [7].
Sewage settling pond.
In the last steps of the physical treatment of wastewater, it is necessary to provide a solution for the removal of very fine sand. One of the best solutions in these conditions is floating using equipment such as a classifier. Grit Classifier is placed in a simple but functional wastewater treatment equipment group that has different parts such as body, cochlear conveyor, and Electra Gearbox. Water enters the grit classifier body from the inlet valve. The cochlear conveyor flows the strip and creates centrifugal force. Fine particles and sand grains are separated from the water due to the creation of this force. They move to the device output and exit from it. Finally, wastewater without sand particles and similar items will be obtained.
Active pharmaceutical ingredient (API) is one of the most widely used and oldest systems for removing fat and oil from water, wastewater, and wastewater. These systems tend to remove free oil down to less than 15 mg L−1 [7]. The construction of water and oil separators by API method is similar to a rectangular clearinghouse, although they have different sizes and design details.
These grease traps are used to remove free oil as well as solid particles from wastewaters of refineries, petrochemicals and chemical plants and other industries. These grease traps are designed according to the standards published by the American Petroleum Institute. The basis of this type of separator is the difference in specific gravity. Less specifically-weighted liquid (usual oil) is collected from the surface, while the fluid with more specific gravity remains in the lower part. Wastewater may contain insoluble oil, sludge, and some soluble components. In common API degreasers, wastewater is initially collected in a pretreatment section for sludge collection. Baffles allow the sewage flow to move slowly towards the outlet, and the oil is separated from the water and effluent.
Usually, in the process of API grease traps, the oil layer, which may contain amounts of water and suspended solids, must be continuously emptied. This layer of isolated oil may be reprocessed or destroyed to recover valuable products. The sedimentary layer containing solid particles formed at the bottom of the degreaser is removed by a remover (or similar device) and a sludge pump.
In the design of API grease traps and other similar gravity tanks, if the input current meets the following conditions, the performance of the grease traps will be difficult:
The average size of oil droplets in the feed is less than 150 microns,
Oil density is greater than 925 (Kg m−3),
Water temperature is less than 5°C,
The amount of hydrocarbon in the inlet flow is high.
In addition to the grit classifier at this stage, different types of grease traps can also be used. For example, CPI degreaser is one of the most applicable equipment in this field. It is a kind of gravity separator and causes colloidal particles suspended in wastewater with a size of at least 50 microns to be separated from wastewater. This type of degreaser, sometimes called Tilted Plate Interceptor, has widely replaced API separators and primary settling tanks [8].
In CPI fat, the inlet wastewater is transferred to the machine to diagonal plates at an angle of 45 to 60 degrees. These plates have resin-reinforced layers, eventually causing the fat particles to settle above the surface of the sewage and the rest that weighs heavier. The simple structure of this method reduces the cost of construction and maintenance of facilities. One of the most important uses of CPI separators is oil and gas refineries, oil terminals and ports, repair shops, food industry, detergent, and chemical production industries, automobile manufacturing, and petrochemical industries. The advantages of this method are:
High efficiency of oil and fat removal
Low energy consumption
Simple operation
Using corrosion-resistant plates, acid, alkalinity
The dense structure raises concerns about deformation.
The removal of pollutants and colloidal particles by injecting compressed air into the effluent is called “Liquid Air Flotation” or “Degradation” of DAF wastewater. As a result of this action, finely released bubbles cling to colloidal particles suspended in the sewer, causing the particles to float on the surface where they are collected by the skimmer and discharged into a sludge storage tank (Figure 7). Due to the high efficiency of the DAF degradation system, this equipment is widely used in various industries such as oil and gas refineries, food factories, and chemicals [7]. DAF is an alternative to sedimentation [9].
Dissolved air flotation system configuration [
In the design process of the DAF wastewater degradation machine, several steps are considered for the removal of oil and colloidal particles suspended in water, including [10]:
Compressed air enters the reservoir and storage of sewage and water, causing bubbles in the fluid.
Bubbles created in the liquid cling to colloidal particles and transfer to the highest level of the liquid.
After oily and colloidal particles are placed on the surface of the water, they are collected using skimmers.
To increase the efficiency of the DAF wastewater degradation system, it is better to use coagulants according to the fluid type and particulate matter in it. To do this, add to the inlet effluent of coagulants and polymers to make the load of the particles. For this purpose, spiral tubes are used, which on the one hand, coagulants are injected in different parts, and on the other hand, an air mixture with pressurized liquid is injected into these tubes for better mixing.
In the DAF grease trap system, some of the cleaned and cleared water is inserted into the flocculants pipes and part of it is transferred directly to the floating unit. Excess treated water is also removed from the DAF system. Clearness of the outlet water from the DAF unit is one of the criteria for the proper operation of this system.
In some cases, coagulation and flocculation tanks are used instead of flocculants tubes. In this case, the coagulants are mixed with effluent in the coagulation tank for about 5 minutes and then injected into the DAF. This process is superior to tubular flocculants when the input effluent is not neutralized and there is enough time to neutralize and on the other hand it is easily controlled by the user.
The objective of the Coagulation Process is to create micro-floc from particulate matter, agglomerate the particles, so that they can settle and move to the sedimentation process. At the Flocculation Process stage, another chemical can be added, a polymer, which helps keep the macro flocs together. Essentially it helps make the bridge between the micro flocs stronger when forming the macro-flocs. A Flocculator is three or more basins with separate mixers. At each stage there are various sizes of flocs, as the size of the flocs increase, the power on the mixers is decreased, to prevent shear, and not damage the flocs (Figures 8 and 9).
Coagulation and Flocculation Process and Mixing Essentials [
Dissolved air flotation thickener [
Wastewater treatment is a process in which wastewater (water that is no longer needed or suitable for use) is converted into water that can be restored to the environment and drained in the wild. Wastewater treatment procedures are carried out in 3 ways: chemical treatment, physical treatment and biological treatment.
Physical treatment of wastewater is when physical and mechanical properties and separation and removal of external particulate matter from wastewater are used. Littering, grading, floating, sequestration and other processes are examples of these.
Physical wastewater treatment is the first step in industrial and sanitary wastewater treatment and not only improves the effectiveness of subsequent processes, but also protects chemical and biological treatment equipment. The equipment and techniques used in physical wastewater treatment vary depending on the type of wastewater and the quality of the wastewater.
Physical methods of water and wastewater treatment include different stages of settling, filtration, and aeration that were discussed in this chapter.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
\\n\\n\\n"}]'},components:[{type:"htmlEditorComponent",content:'
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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in Complex Networks: An Overview and Some Modified Methods",slug:"spreading-information-in-complex-networks-an-overview-and-some-modified-methods",totalDownloads:1473,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"The knowledge of node’s ability and importance in spreading information in a complex network is important for developing efficient methods either to decelerate spreading in the case of diseases or to accelerate spreading in the case of information flow, which would benefit the whole population. Some systems are highly affected by a small fraction of influential nodes. Number of fast and efficient spreaders in a network is much less compared to the number of ordinary members. Information about the influential spreaders is significant in the planning for the control of propagation of critical pieces of information in a social or information network. Identifying important members who act as the fastest and efficient spreaders is the focal theme of a large number of research papers. Researchers have identified approximately 10 different methods for this purpose. Degree centrality, closeness centrality, betweenness centrality, k‐core decomposition, mixed degree decomposition, improved k‐shell decomposition, etc., are some of these methods. In this expository article, we review all previous works done in the field of identifying potential spreaders in a network.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"Reji Kumar Karunakaran, Shibu Manuel and Edamana Narayanan\nSatheesh",authors:[{id:"200190",title:"Dr.",name:"Reji Kumar",middleName:null,surname:"Karunakaran",slug:"reji-kumar-karunakaran",fullName:"Reji Kumar Karunakaran"},{id:"200193",title:"Mr.",name:"Manuel",middleName:null,surname:"Shibu",slug:"manuel-shibu",fullName:"Manuel Shibu"},{id:"200194",title:"Dr.",name:"E N",middleName:null,surname:"Satheesh",slug:"e-n-satheesh",fullName:"E N Satheesh"}]},{id:"55541",doi:"10.5772/intechopen.68703",title:"Modeling Rooted in‐Trees by Finite p‐Groups",slug:"modeling-rooted-in-trees-by-finite-p-groups",totalDownloads:1132,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Graph theoretic foundations for a kind of infinite rooted in-trees T(R)=(V,E) with root R, weighted vertices v ∈ V, and weighted directed edges e∈E⊂V×V are described. Vertex degrees deg(v) are always finite but the trees contain infinite paths (vi)i≥0. A concrete group theoretic model of the rooted in-trees T(R) is introduced by representing vertices by isomorphism classes of finite p-groups G, for a fixed prime p, and directed edges by epimorphisms π: G → πG of finite p-groups with characteristic kernels ker(π). The weight of a vertex G is realized by its nuclear rank n(G) and the weight of a directed edge π is realized by its step size s(π)=logp(#ker(π)). These invariants are essential for understanding the phenomenon of multifurcation. Pattern recognition methods are used for finding finite subgraphs which repeat indefinitely. Several periodicities admit the reduction of the complete infinite graph to finite patterns. The proof is based on infinite limit groups and successive group extensions. It is underpinned by several explicit algorithms. As a final application, it is shown that fork topologies, arising from repeated multifurcations, provide a convenient description of complex navigation paths through the trees, which are of the greatest importance for recent progress in determining p-class field towers of algebraic number fields.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"Daniel C. Mayer",authors:[{id:"198580",title:"Dr.",name:"Daniel C.",middleName:null,surname:"Mayer",slug:"daniel-c.-mayer",fullName:"Daniel C. Mayer"}]},{id:"57771",doi:"10.5772/intechopen.71774",title:"Governance Modeling: Dimensionality and Conjugacy",slug:"governance-modeling-dimensionality-and-conjugacy",totalDownloads:1310,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"The Q-analysis governance approach and the use of simplicial complexes—type of hypergraph—allow to introduce the formal concepts of dimension and conjugacy between the network of entities involved in governance (typically organizations) and the networks of those attributes taken into account (e.g. their competences), which offer a specific angle of analysis. The different sources of existing data (e.g. textual corpora) to feed the analysis of governance—environmental in particular—are mentioned, their reliability is briefly discussed and the required pre-processing steps are identified in the perspective of evidence-based analyses. Various indices are constructed and evaluated to characterize the context of governance as a whole, at mesoscale, or locally, i.e. at the level of each of the entities and each of the attributes considered. The analysis of ideal-type stylizing boundary cases provides useful references to the analysis of concrete systems of governance and to the interpretation of their empirically observed properties. The use of this governance modeling approach is illustrated by the analysis of a health-environment governance system in Southeast Asia, in the context of a One Health approach.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"Pierre Mazzega, Claire Lajaunie and Etienne Fieux",authors:[{id:"220099",title:"Dr.",name:"Pierre",middleName:null,surname:"Mazzega",slug:"pierre-mazzega",fullName:"Pierre Mazzega"},{id:"220102",title:"Dr.",name:"Claire",middleName:null,surname:"Lajaunie",slug:"claire-lajaunie",fullName:"Claire Lajaunie"},{id:"220103",title:"Prof.",name:"Etienne",middleName:null,surname:"Fieux",slug:"etienne-fieux",fullName:"Etienne Fieux"}]},{id:"57940",doi:"10.5772/intechopen.72145",title:"Graph-Based Decision Making in Industry",slug:"graph-based-decision-making-in-industry",totalDownloads:1667,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Decision-making in industry can be focused on different types of problems. Classification and prediction of decision problems can be solved with the use of a decision tree, which is a graph-based method of machine learning. In the presented approach, attribute-value system and quality function deployment (QFD) were used for decision problem analysis and training dataset preparation. A decision tree was applied for generating decision rules.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"Izabela Kutschenreiter-Praszkiewicz",authors:[{id:"218951",title:"Associate Prof.",name:"Izabela",middleName:null,surname:"Kutschenreiter-Praszkiewicz",slug:"izabela-kutschenreiter-praszkiewicz",fullName:"Izabela Kutschenreiter-Praszkiewicz"}]},{id:"55375",doi:"10.5772/intechopen.68690",title:"An Example Usage of Graph Theory in Other Scientific Fields: On Graph Labeling, Possibilities and Role of Mind/Consciousness",slug:"an-example-usage-of-graph-theory-in-other-scientific-fields-on-graph-labeling-possibilities-and-role",totalDownloads:1796,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"This paper provides insights into some aspects of the possibilities and role of mind, consciousness, and their relation to mathematical logic with the application of problem solving in the fields of psychology and graph theory. This work aims to dispel certain long-held notions of a severe psychological disorder and a well-known graph labeling conjecture. The applications of graph labelings of various types for various kinds of graphs are being discussed. Certain results in graph labelings using computer software are presented with a direction to discover more applications.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"Auparajita Krishnaa",authors:[{id:"198790",title:"Dr.",name:"Auparajita",middleName:null,surname:"Krishnaa",slug:"auparajita-krishnaa",fullName:"Auparajita Krishnaa"}]}],mostDownloadedChaptersLast30Days:[{id:"71899",title:"Moments of Catalan Triangle Numbers",slug:"moments-of-catalan-triangle-numbers",totalDownloads:529,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In this chapter, we consider the Catalan numbers, \n\n\nC\nn\n\n=\n\n1\n\nn\n+\n1\n\n\n\n\n\n\n2\nn\n\n\n\n\nn\n\n\n\n\n\n, and two of their generalizations, Catalan triangle numbers, \n\n\nB\n\nn\n,\nk\n\n\n\n and \n\n\nA\n\nn\n,\nk\n\n\n\n, for \n\nn\n,\nk\n∈\nN\n\n. They are combinatorial numbers and present interesting properties as recursive formulae, generating functions and combinatorial interpretations. We treat the moments of these Catalan triangle numbers, i.e., with the following sums: \n\n\n∑\n\nk\n=\n1\n\nn\n\n\nk\nm\n\n\nB\n\nn\n,\nk\n\nj\n\n,\n\n∑\n\nk\n=\n1\n\n\nn\n+\n1\n\n\n\n\n\n2\nk\n−\n1\n\n\nm\n\n\nA\n\nn\n,\nk\n\nj\n\n,\n\n for \n\nj\n,\nn\n∈\nN\n\n and \n\nm\n∈\nN\n∪\n\n0\n\n\n. We present their closed expressions for some values of \n\nm\n\n and \n\nj\n\n. Alternating sums are also considered for particular powers. Other famous integer sequences are studied in Section 3, and its connection with Catalan triangle numbers are given in Section 4. Finally we conjecture some properties of divisibility of moments and alternating sums of powers in the last section.",book:{id:"8142",slug:"number-theory-and-its-applications",title:"Number Theory and Its Applications",fullTitle:"Number Theory and Its Applications"},signatures:"Pedro J. Miana and Natalia Romero",authors:null},{id:"55642",title:"Monophonic Distance in Graphs",slug:"monophonic-distance-in-graphs",totalDownloads:1508,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"For any two vertices u and v in a connected graph G, a u − v path is a monophonic path if it contains no chords, and the monophonic distance dm(u, v) is the length of a longest u − v monophonic path in G. For any vertex v in G, the monophonic eccentricity of v is em(v) = max {dm(u, v) : u ∈ V}. The subgraph induced by the vertices of G having minimum monophonic eccentricity is the monophonic center of G, and it is proved that every graph is the monophonic center of some graph. Also it is proved that the monophonic center of every connected graph G lies in some block of G. With regard to convexity, this monophonic distance is the basis of some detour monophonic parameters such as detour monophonic number, upper detour monophonic number, forcing detour monophonic number, etc. The concept of detour monophonic sets and detour monophonic numbers by fixing a vertex of a graph would be introduced and discussed. Various interesting results based on these parameters are also discussed in this chapter.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"P. Titus and A.P. Santhakumaran",authors:[{id:"198301",title:"Dr.",name:"P.",middleName:null,surname:"Titus",slug:"p.-titus",fullName:"P. Titus"},{id:"199035",title:"Prof.",name:"A. P.",middleName:null,surname:"Santhakumaran",slug:"a.-p.-santhakumaran",fullName:"A. P. Santhakumaran"}]},{id:"71501",title:"Accelerating DNA Computing via PLP-qPCR Answer Read out to Solve Traveling Salesman Problems",slug:"accelerating-dna-computing-via-plp-qpcr-answer-read-out-to-solve-traveling-salesman-problems",totalDownloads:742,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"An asymmetric, fully-connected 8-city traveling salesman problem (TSP) was solved by DNA computing using the ordered node pair abundance (ONPA) approach through the use of pair ligation probe quantitative real time polymerase chain reaction (PLP-qPCR). The validity of using ONPA to derive the optimal answer was confirmed by in silico computing using a reverse-engineering method to reconstruct the complete tours in the feasible answer set from the measured ONPA. The high specificity of the sequence-tagged hybridization, and ligation that results from the use of PLPs significantly increased the accuracy of answer determination in DNA computing. When combined with the high throughput efficiency of qPCR, the time required to identify the optimal answer to the TSP was reduced from days to 25 min.",book:{id:"8241",slug:"novel-trends-in-the-traveling-salesman-problem",title:"Novel Trends in the Traveling Salesman Problem",fullTitle:"Novel Trends in the Traveling Salesman Problem"},signatures:"Fusheng Xiong, Michael Kuby and Wayne D. Frasch",authors:[{id:"14757",title:"Prof.",name:"Wayne",middleName:null,surname:"Frasch",slug:"wayne-frasch",fullName:"Wayne Frasch"},{id:"317054",title:"Prof.",name:"Michael",middleName:null,surname:"Kuby",slug:"michael-kuby",fullName:"Michael Kuby"},{id:"317055",title:"Dr.",name:"Fusheng",middleName:null,surname:"Xiong",slug:"fusheng-xiong",fullName:"Fusheng Xiong"}]},{id:"72027",title:"Identification of Eigen-Frequencies and Mode-Shapes of Beams with Continuous Distribution of Mass and Elasticity and for Various Conditions at Supports",slug:"identification-of-eigen-frequencies-and-mode-shapes-of-beams-with-continuous-distribution-of-mass-an",totalDownloads:862,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"In the present article, an equivalent three degrees of freedom (DoF) system of two different cases of inverted pendulums is presented for each separated case. The first case of inverted pendulum refers to an amphi-hinge pendulum that possesses distributed mass and stiffness along its height, while the second case of inverted pendulum refers to an inverted pendulum with distributed mass and stiffness along its height. These vertical pendulums have infinity number of degree of freedoms. Based on the free vibration of the above-mentioned pendulums according to partial differential equation, a mathematically equivalent three-degree of freedom system is given for each case, where its equivalent mass matrix is analytically formulated with reference on specific mass locations along the pendulum height. Using the three DoF model, the first three fundamental frequencies of the real pendulum can be identified with very good accuracy. Furthermore, taking account the 3 × 3 mass matrix, it is possible to estimate the possible pendulum damages using a known technique of identification mode-shapes via records of response accelerations. Moreover, the way of instrumentation with a local network by three accelerometers is given via the above-mentioned three degrees of freedom.",book:{id:"8142",slug:"number-theory-and-its-applications",title:"Number Theory and Its Applications",fullTitle:"Number Theory and Its Applications"},signatures:"Triantafyllos K. Makarios",authors:[{id:"69418",title:"Prof.",name:"Triantafyllos",middleName:"Konstantinos",surname:"Makarios",slug:"triantafyllos-makarios",fullName:"Triantafyllos Makarios"}]},{id:"57940",title:"Graph-Based Decision Making in Industry",slug:"graph-based-decision-making-in-industry",totalDownloads:1667,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Decision-making in industry can be focused on different types of problems. Classification and prediction of decision problems can be solved with the use of a decision tree, which is a graph-based method of machine learning. In the presented approach, attribute-value system and quality function deployment (QFD) were used for decision problem analysis and training dataset preparation. A decision tree was applied for generating decision rules.",book:{id:"5842",slug:"graph-theory-advanced-algorithms-and-applications",title:"Graph Theory",fullTitle:"Graph Theory - Advanced Algorithms and Applications"},signatures:"Izabela Kutschenreiter-Praszkiewicz",authors:[{id:"218951",title:"Associate Prof.",name:"Izabela",middleName:null,surname:"Kutschenreiter-Praszkiewicz",slug:"izabela-kutschenreiter-praszkiewicz",fullName:"Izabela Kutschenreiter-Praszkiewicz"}]}],onlineFirstChaptersFilter:{topicId:"1399",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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