\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"6515",leadTitle:null,fullTitle:"Emerging Waveguide Technology",title:"Emerging Waveguide Technology",subtitle:null,reviewType:"peer-reviewed",abstract:"Recently, the rapid development of radiofrequency (RF)/microwave and photonic/optical waveguide technologies has had a significant impact on the current electronic industrial, medical and information and communication technology (ICT) fields. This book is a self-contained collection of valuable scholarly papers related to waveguide design, modeling, and applications. This book contains 20 chapters that cover three main subtopics of waveguide technologies, namely RF and microwave waveguide, photonic and optical waveguide and waveguide analytical solutions. Hence, this book is particularly useful to the academics, scientists, practicing researchers and postgraduate students whose work relates to the latest waveguide technologies.",isbn:"978-1-78923-493-0",printIsbn:"978-1-78923-492-3",pdfIsbn:"978-1-83881-516-5",doi:"10.5772/intechopen.71142",price:139,priceEur:155,priceUsd:179,slug:"emerging-waveguide-technology",numberOfPages:384,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"12ab2b13b1ca330409dc239647a53895",bookSignature:"Kok Yeow You",publishedDate:"August 1st 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6515.jpg",numberOfDownloads:25837,numberOfWosCitations:45,numberOfCrossrefCitations:46,numberOfCrossrefCitationsByBook:6,numberOfDimensionsCitations:68,numberOfDimensionsCitationsByBook:5,hasAltmetrics:1,numberOfTotalCitations:159,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 26th 2017",dateEndSecondStepPublish:"October 17th 2017",dateEndThirdStepPublish:"December 16th 2017",dateEndFourthStepPublish:"March 6th 2018",dateEndFifthStepPublish:"May 5th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"188673",title:"Dr.",name:"Kok Yeow",middleName:null,surname:"You",slug:"kok-yeow-you",fullName:"Kok Yeow You",profilePictureURL:"https://mts.intechopen.com/storage/users/188673/images/5521_n.jpg",biography:"Dr. Kok Yeow You obtained his BSc degree in Physics (Honors) from the Universiti Kebangsaan Malaysia (UKM) in 2001. He pursued his MSc degree in Microwave from the Faculty of Science in 2003 and his PhD degree in Wave Propagation from the Institute for Mathematical Research, Universiti Putra Malaysia (UPM), Serdang, Selangor, Malaysia in 2006. His main personal research interest includes the theory, simulation, and instrumentation of electromagnetic wave propagation at microwave frequencies focusing on the development of microwave passive devices and sensors for medical and agricultural applications. For the past 17 years, he has developed numerous projects concerning microwave waveguide measurement systems for agri-/food, biomedical processing, and microwave devices for biomedical treatments, as well as numerical electromagnetic modeling.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Technology Malaysia",institutionURL:null,country:{name:"Malaysia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"116",title:"Electrical and Electronic Engineering",slug:"electrical-and-electronic-engineering"}],chapters:[{id:"61901",title:"Broadband Slotted Waveguide Array Antenna",doi:"10.5772/intechopen.78308",slug:"broadband-slotted-waveguide-array-antenna",totalDownloads:1899,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:1,abstract:"This chapter describes the design and development of broadband slotted waveguide array (SWA) antenna. Conventional SWA antenna offers a few percentages of bandwidth, which can be enhanced using proposed novel differential feeding technique which electrically divides large resonating SWA into wideband subarrays by creating virtual shorts. This chapter discusses concepts to achieve broadband nature of SWA antennas, design, development, and characterization of edge fed slotted waveguide array antenna, coupling slot fed SWA antenna, and high efficiency broadband slotted waveguide array. The developed SWA antennas are characterized and their measured results are presented. The developed prototype of proposed SWA antenna demonstrates measured return loss better than −17 dB over 7.6% bandwidth and achieves 90.2% antenna efficiency. This chapter also briefs about planar broadband SWA antenna and its prototype development and characterization.",signatures:"Yogesh Tyagi and Pratik Mevada",downloadPdfUrl:"/chapter/pdf-download/61901",previewPdfUrl:"/chapter/pdf-preview/61901",authors:[{id:"228031",title:"Mr.",name:"Yogesh",surname:"Tyagi",slug:"yogesh-tyagi",fullName:"Yogesh Tyagi"},{id:"228559",title:"Mr.",name:"Pratik",surname:"Mevada",slug:"pratik-mevada",fullName:"Pratik Mevada"}],corrections:null},{id:"61284",title:"Photonic Crystal Waveguides",doi:"10.5772/intechopen.76797",slug:"photonic-crystal-waveguides",totalDownloads:1342,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The original results of theoretical and experimental studies and the properties of microwave one-dimensional waveguide photonic crystals have been generalized. Methods for describing the electrodynamic characteristics of photonic crystals and their relationship with the parameters of periodic structures filling the waveguides have been presented. The results of an investigation on the characteristics of microwave waveguide photonic crystals made in the form of dielectric matrices with air inclusions have been presented. The model of effective dielectric permittivity has been proposed for describing the characteristics of the investigated photonic crystals containing layers with a large number of air inclusions. New types of microwave low-dimensional waveguide photonic crystals containing periodically alternating elements that are sources of higher type waves have been described. The possibility of effective control of the amplitude-frequency characteristics of microwave photonic crystals by means of electric and magnetic fields has been analyzed. Examples of new applications of waveguide photonic crystals in the microwave range have been given: the measuring parameters of the materials and semiconductor nanostructures that play the role of the microwave photonic crystals' periodicity defect; the resonators of near-field microwave microscopes; small-sized matched loads for centimeter and millimeter wavelength ranges on the basis of microwave photonic crystals.",signatures:"Dmitry Usanov and Alexander Skripal",downloadPdfUrl:"/chapter/pdf-download/61284",previewPdfUrl:"/chapter/pdf-preview/61284",authors:[{id:"228739",title:"Prof.",name:"Dmitry",surname:"Usanov",slug:"dmitry-usanov",fullName:"Dmitry Usanov"},{id:"230179",title:"Prof.",name:"Alexander",surname:"Skripal",slug:"alexander-skripal",fullName:"Alexander Skripal"}],corrections:null},{id:"60948",title:"High-Gain Amplifier Module Integrating a Waveguide into the Module Case for Millimeter Wave Applications",doi:"10.5772/intechopen.76622",slug:"high-gain-amplifier-module-integrating-a-waveguide-into-the-module-case-for-millimeter-wave-applicat",totalDownloads:820,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A high-gain amplifier module with integrated waveguide (WG) has been presented for millimeter wave applications. In order to improve the isolation between the amplification stages in the multi-stage amplifier module, an isolated WG is integrated into the module case. It is possible to effectively suppress the oscillation occurring in the high gain stage. Microstrip line (MSL)-to-WG transitions are designed and fabricated on a 5 mil thick RT5880 substrate for interconnection of the isolated WG, input/output WG and amplifier PCB in a cascaded two-stage high gain amplifier module. The transition loss of −0.44 dB is obtained at 40 GHz and return-loss (S11) bandwidth below −10 dB is from 34.1 to 50 GHz. The fabricated high-gain amplifier module shows a high gain over 39.7 dB from 38 to 41 GHz. At 38.7 GHz, its maximum gain of 44.25 dB is achieved.",signatures:"Young Chul Lee",downloadPdfUrl:"/chapter/pdf-download/60948",previewPdfUrl:"/chapter/pdf-preview/60948",authors:[{id:"188444",title:"Prof.",name:"Young Chul",surname:"Lee",slug:"young-chul-lee",fullName:"Young Chul Lee"}],corrections:null},{id:"61194",title:"Mathematical Analysis of Electrical Breakdown Effects in Waveguides",doi:"10.5772/intechopen.76973",slug:"mathematical-analysis-of-electrical-breakdown-effects-in-waveguides",totalDownloads:892,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The designers of microwave devices in the industry use the analytical solutions of the corona discharge equation to determine the minimum power breakdown threshold, in a particular device, such as waveguides and filters, and know whether it is in the established margins. There are two main ways to determine the breakdown threshold of a waveguide analytically; the most commonly used describes the plasma density generation completely as a function of the geometry by using the characteristic diffusion length, while the second is a more thorough method that involves the use of the effective diffusion length which considers collision frequency and electric field into the equations. Hence the aim of the designers is to obtain the closest results to experimental results, both methods must be considered in addition to the environmental changes so that they know the operational limits. This chapter describes the different methods to obtain analytical results for the breakdown threshold in any rectangular waveguide device, the influence of environmental conditions in the analysis and the inhomogeneous electric field effect inside the devices.",signatures:"Isaac Medina and Primo-Alberto Calva",downloadPdfUrl:"/chapter/pdf-download/61194",previewPdfUrl:"/chapter/pdf-preview/61194",authors:[{id:"225982",title:"Dr.",name:"Isaac",surname:"Medina",slug:"isaac-medina",fullName:"Isaac Medina"},{id:"225986",title:"Dr.",name:"Primo",surname:"Calva",slug:"primo-calva",fullName:"Primo Calva"}],corrections:null},{id:"62346",title:"Optical Waveguide for Measurement Application",doi:"10.5772/intechopen.76781",slug:"optical-waveguide-for-measurement-application",totalDownloads:902,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The chapter provides the analysis of the behaviour of Mach Zehnder interferometer waveguide (MZIW) sensing structure and establishes the general design principles. Photonics interferometers have been widely used because of their highly sensitive detection technique. The present study is based on the MZIW structure for sensing application and deals with interferometer single-mode transmission. Theoretically, short wavelength and high difference in index (Δη) results in the low depth of the evanescence wave and increase in sensitivity. MZIW under consideration is very small in size hence it is very difficult to guide the light into waveguide. The output monitor detection sensitivity of the entire MZI structure depends on light-guiding efficiency. To maintain minimum losses at various micro-branches of the entire MZIW structure, effective light propagation is important and it is a critical parameter of the entire interferometer. Various tests have been carried out to study the effects of the Y branch angle variation on light guiding into the MZIW structure especially in measurement application.",signatures:"Prashant Bansilal Patel and Satish T. Hamde",downloadPdfUrl:"/chapter/pdf-download/62346",previewPdfUrl:"/chapter/pdf-preview/62346",authors:[{id:"223158",title:"Mr.",name:"Prashant",surname:"Patel",slug:"prashant-patel",fullName:"Prashant Patel"},{id:"245227",title:"Prof.",name:"Satish",surname:"Hamde",slug:"satish-hamde",fullName:"Satish Hamde"}],corrections:null},{id:"61838",title:"Review on Optical Waveguides",doi:"10.5772/intechopen.77150",slug:"review-on-optical-waveguides",totalDownloads:4777,totalCrossrefCites:19,totalDimensionsCites:29,hasAltmetrics:1,abstract:"Optical devices are necessary to meet the anticipated future requirements for ultrafast and ultrahigh bandwidth communication and computing. All optical information processing can overcome optoelectronic conversions that limit both the speed and bandwidth and are also power consuming. The building block of an optical device/circuit is the optical waveguide, which enables low-loss light propagation and is thereby used to connect components and devices. This chapter reviews optical waveguides and their classification on the basis of geometry (Non-Planar (Slab/Optical Fiber)/Planar (Buried Channel, Strip-Loaded, Wire, Rib, Diffused, Slot, etc.)), refractive index (Step/Gradient Index), mode propagation (Single/Multimode), and material platform (Glass/Polymer/Semiconductor, etc.). A comparative analysis of waveguides realized in different material platforms along with the propagation loss is also presented.",signatures:"Shankar Kumar Selvaraja and Purnima Sethi",downloadPdfUrl:"/chapter/pdf-download/61838",previewPdfUrl:"/chapter/pdf-preview/61838",authors:[{id:"236949",title:"Prof.",name:"Shankar Kumar",surname:"Selvaraja",slug:"shankar-kumar-selvaraja",fullName:"Shankar Kumar Selvaraja"},{id:"249514",title:"Dr.",name:"Purnima",surname:"Sethi",slug:"purnima-sethi",fullName:"Purnima Sethi"}],corrections:null},{id:"61264",title:"Graphene Based Waveguides",doi:"10.5772/intechopen.76796",slug:"graphene-based-waveguides",totalDownloads:1521,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Graphene, which is well known as a one-atom thick carbon allotrope, has drawn lots of attention since its first announcement due to remarkable performance in mechanical, electrical, magnetic, thermal, and optical areas. In particular, unique properties of graphene such as low net absorption in broadband optical band, notably high nonlinear optical effects, and gate-variable optical conductivity make it an excellent candidate for high speed, high performance, and broadband electronic and photonics devices. Embedding graphene into optical devices longitudinally would enhance the light-graphene interaction, which shows great potential in photonic components. Since the carrier density of graphene could be tuned by external gate voltage, chemical doping, light excitation, graphene-based waveguide modulator could be designed to have high flexibility in controlling the absorption and modulation depth. Furthermore, graphene-based waveguides could take advantages in detection, sensing, polarizer, and so on.",signatures:"Xianglian Song, Xiaoyu Dai and Yuanjiang Xiang",downloadPdfUrl:"/chapter/pdf-download/61264",previewPdfUrl:"/chapter/pdf-preview/61264",authors:[{id:"106075",title:"Dr.",name:"Yuanjiang",surname:"Xiang",slug:"yuanjiang-xiang",fullName:"Yuanjiang Xiang"},{id:"226350",title:"Dr.",name:"Xianglian",surname:"Song",slug:"xianglian-song",fullName:"Xianglian Song"},{id:"226500",title:"Prof.",name:"Xiaoyu",surname:"Dai",slug:"xiaoyu-dai",fullName:"Xiaoyu Dai"}],corrections:null},{id:"61408",title:"Lithium Niobate Optical Waveguides and Microwaveguides",doi:"10.5772/intechopen.76798",slug:"lithium-niobate-optical-waveguides-and-microwaveguides",totalDownloads:2259,totalCrossrefCites:5,totalDimensionsCites:5,hasAltmetrics:1,abstract:"Lithium niobate has attracted much attention since the 1970s due to its capacity to modify the light by means of an electric control. In this chapter, we review the evolution of electro-optical (EO) lithium niobate waveguides throughout the years, from Ti-indiffused waveguides to photonic crystals. The race toward ever smaller EO components with ever-lower optical losses and power consumption has stimulated numerous studies, the challenge consisting of strongly confining the light while preserving low losses. We show how waveguides have evolved toward ridges or thin film-based microguides to increase the EO efficiency and reduce the driving voltage. In particular, a focus is made on an easy-to-implement technique using a circular precision saw to produce thin ridge waveguides or suspended membranes with low losses.",signatures:"Nadège Courjal, Maria-Pilar Bernal, Alexis Caspar, Gwenn Ulliac,\nFlorent Bassignot, Ludovic Gauthier-Manuel and Miguel Suarez",downloadPdfUrl:"/chapter/pdf-download/61408",previewPdfUrl:"/chapter/pdf-preview/61408",authors:[{id:"31946",title:"Mr.",name:"Gwenn",surname:"Ulliac",slug:"gwenn-ulliac",fullName:"Gwenn Ulliac"},{id:"31950",title:"Mr.",name:"Florent",surname:"Bassignot",slug:"florent-bassignot",fullName:"Florent Bassignot"},{id:"223063",title:"Associate Prof.",name:"Nadege",surname:"Bodin Courjal",slug:"nadege-bodin-courjal",fullName:"Nadege Bodin Courjal"},{id:"227862",title:"Prof.",name:"Maria-Pilar",surname:"Bernal",slug:"maria-pilar-bernal",fullName:"Maria-Pilar Bernal"},{id:"239866",title:"Mr.",name:"Alexis",surname:"Caspar",slug:"alexis-caspar",fullName:"Alexis Caspar"},{id:"239868",title:"Mr.",name:"Ludovic",surname:"Gautier-Manuel",slug:"ludovic-gautier-manuel",fullName:"Ludovic Gautier-Manuel"},{id:"239932",title:"Dr.",name:"Miguel",surname:"Suarez",slug:"miguel-suarez",fullName:"Miguel Suarez"}],corrections:null},{id:"59919",title:"Raman Solitons in Nanoscale Optical Waveguides, with Metamaterials, Having Polynomial Law Nonlinearity Using Collective Variables",doi:"10.5772/intechopen.75121",slug:"raman-solitons-in-nanoscale-optical-waveguides-with-metamaterials-having-polynomial-law-nonlinearity",totalDownloads:985,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A mathematical analysis is conducted to illustrate the controllability of the Raman soliton self-frequency shift with polynomial nonlinearity in metamaterials by using collective variable method. The polynomial nonlinearity is due to the expanding nonlinear polarization \n\n\nP\nNL\n\n\n in a series over the field \n\nE\n\n up to the seventh order. Gaussian assumption is selected to these pulses on a generalized mode. The numerical simulation of soliton parameter variation is given for the Gaussian pulse parameters.",signatures:"Yanan Xu, Jun Ren and Matthew C. Tanzy",downloadPdfUrl:"/chapter/pdf-download/59919",previewPdfUrl:"/chapter/pdf-preview/59919",authors:[{id:"223008",title:"Dr.",name:"Yanan",surname:"Xu",slug:"yanan-xu",fullName:"Yanan Xu"},{id:"223668",title:"Dr.",name:"Matthew",surname:"Tanzy",slug:"matthew-tanzy",fullName:"Matthew Tanzy"},{id:"248250",title:"Dr.",name:"Jun",surname:"Ren",slug:"jun-ren",fullName:"Jun Ren"}],corrections:null},{id:"60221",title:"Silicon-on-Insulator Slot Waveguides: Theory and Applications in Electro-Optics and Optical Sensing",doi:"10.5772/intechopen.75539",slug:"silicon-on-insulator-slot-waveguides-theory-and-applications-in-electro-optics-and-optical-sensing",totalDownloads:1855,totalCrossrefCites:16,totalDimensionsCites:26,hasAltmetrics:0,abstract:"This chapter deals with the basic concept of silicon-on-insulator (SOI) slot waveguides, including slot waveguide theory, fabrication steps, and applications. First, in the theory section, a modal field expression and the characteristic equation is derived, which is also valid for higher-order modes. SOI slot waveguide structures are simulated and characteristic values like the effective refractive indices and the field confinement factors are determined. The fabrication section describes typical SOI fabrication steps and the limits of current fabrication techniques. Additionally, developments regarding loss reduction in SOI slot waveguides are given from the fabrication point of view. This is followed by the theory and practice of slot waveguide based electro-optical modulators. Here, the SOI slot waveguide is embedded in an organic nonlinear optical material in order to achieve record-low voltage-length products. In the field of optical sensors, it is shown that slot waveguides enable remarkable waveguide sensitivity for both refractive index sensing and surface sensing.",signatures:"Patrick Steglich",downloadPdfUrl:"/chapter/pdf-download/60221",previewPdfUrl:"/chapter/pdf-preview/60221",authors:[{id:"223128",title:"Dr.",name:"Patrick",surname:"Steglich",slug:"patrick-steglich",fullName:"Patrick Steglich"}],corrections:null},{id:"61148",title:"Investigation of Ring Waveguide Add/Drop with Grating Couple",doi:"10.5772/intechopen.76800",slug:"investigation-of-ring-waveguide-add-drop-with-grating-couple",totalDownloads:908,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The silicon photon technology platform is low transmission loss, small size, low cost of the process and easy integration with electronic components and other characteristics. It is designed to design high-density optical communication network system has a considerable advantage. Such as high-density wavelength division multiplexing (DWDM) system, that is through the different wavelengths of signal processing. So that it can be used for optical connection switches, routing and other applications. It composed of a DWDM system, through the Mach-Zehnder interferometer, ring resonator (Add/Drop), array waveguide grating (AWG) and grating coupler and other structural components. It is designed by components to filter, switch, adjust and detect functions. The characteristics of the ring resonator are for wavelength selection. It is suitable for the design of optical switches, signal switching and modulation applications. It is also the focus of this lab and this chapter to explore and study. The general edge coupling, between the optical fiber and the waveguide dimension is very different. As a result, larger insertion loss is caused. This study uses the vertical coupling method to investigate the characteristics of a ring resonator.",signatures:"Jian-Chiun Liou",downloadPdfUrl:"/chapter/pdf-download/61148",previewPdfUrl:"/chapter/pdf-preview/61148",authors:[{id:"222901",title:"Prof.",name:"Jian-Chiun",surname:"Liou",slug:"jian-chiun-liou",fullName:"Jian-Chiun Liou"}],corrections:null},{id:"60915",title:"Multimode Waveguides on an SOI Platform for Arbitrary Power Splitting Ratio Couplers",doi:"10.5772/intechopen.76799",slug:"multimode-waveguides-on-an-soi-platform-for-arbitrary-power-splitting-ratio-couplers",totalDownloads:921,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Optical power couplers with arbitrary power splitting ratios are important components for many applications such as Mach-Zehnder interferometer-based structures, filters, switches, dispersion compensations, optical interconnects, and microring resonators. In this chapter, we present a new approach to achieve a very high compact coupler with arbitrary power splitting ratios on silicon on insulator (SOI) waveguides. The proposed device requires only one 4×4 multimode interference (MMI) coupler. We use a passive wide SOI waveguide to achieve the phase shifter. The footprint of the whole device is only about 6×150 μm2. A large fabrication tolerance of ±50 nm can be achieved. The modified effective index method, beam propagation method, finite difference method, and finite difference-time difference method are used to optimally design the whole device.",signatures:"Trung-Thanh Le and Duy-Tien Le",downloadPdfUrl:"/chapter/pdf-download/60915",previewPdfUrl:"/chapter/pdf-preview/60915",authors:[{id:"223579",title:"Prof.",name:"Trung-Thanh",surname:"Le",slug:"trung-thanh-le",fullName:"Trung-Thanh Le"},{id:"240025",title:"Dr.",name:"Duy-Tien",surname:"Le",slug:"duy-tien-le",fullName:"Duy-Tien Le"}],corrections:null},{id:"60830",title:"Longitudinal Differential Protection of Power Systems Transmission Lines Using Optical Waveguide",doi:"10.5772/intechopen.76621",slug:"longitudinal-differential-protection-of-power-systems-transmission-lines-using-optical-waveguide",totalDownloads:1159,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter describes using optical waveguide for communication between two relays on the opposite ends of the power systems transmission line (or transmission line). Transmission lines are a very important part of the power system. Because of that, relay protection must be fast and safe. Longitudinal differential protection satisfies these requirements. Pilot wire differential relays are commonly used for the protection of short lines. The existence of the pilot wires is a disadvantage. This protection is limited to lines of a few tens of kilometers. However, if optical protection ground wires (OPGWs) are used, instead of pilot wires, the length of the line ceases to be a limiting factor. The following sections tell more about constructions, assembly and utilization of the optical waveguides in differential protection. Also, the newest algorithms of this protection are listed.",signatures:"Tomislav Rajić",downloadPdfUrl:"/chapter/pdf-download/60830",previewPdfUrl:"/chapter/pdf-preview/60830",authors:[{id:"227492",title:"M.Sc.",name:"Tomislav",surname:"Rajić",slug:"tomislav-rajic",fullName:"Tomislav Rajić"}],corrections:null},{id:"60096",title:"End-Fire Mode Spectroscopy: A Measuring Technique for Optical Waveguides",doi:"10.5772/intechopen.75558",slug:"end-fire-mode-spectroscopy-a-measuring-technique-for-optical-waveguides",totalDownloads:898,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"End-fire mode spectroscopy technique provides reliable measurement of the whole mode spectrum of optical waveguides having arbitrary cross refractive index profile. The method is based on registration of light beams radiated from the abrupt output edge of the waveguide, with each beam corresponding to the individual waveguide mode. Due to different values of mode propagation constants, modes of different orders demonstrate different refraction angles at the output waveguide face when modes reach that face under the same nonzero inclination angle. Just this feature is used in the technique. Mode excitation is performed directly through the input waveguide face, and therefore the technique can be applied to analyze mode spectrum of arbitrary waveguides, including the ones with non-monotonic index profiles (particularly, symmetric step-index profiles or buried graded-index waveguides with any burying depths).",signatures:"Dmitry V. Svistunov",downloadPdfUrl:"/chapter/pdf-download/60096",previewPdfUrl:"/chapter/pdf-preview/60096",authors:[{id:"200376",title:"Dr.",name:"Dmitry",surname:"Svistunov",slug:"dmitry-svistunov",fullName:"Dmitry Svistunov"}],corrections:null},{id:"61252",title:"Polymer Resonant Waveguide Gratings",doi:"10.5772/intechopen.76917",slug:"polymer-resonant-waveguide-gratings",totalDownloads:1082,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter deals with the advances in polymeric waveguide gratings for filtering and integrated optics applications. Optical polymer materials are widely used for planar and corrugated micro-optical waveguide grating structures ranging from down a micrometer to several hundred micrometers. Light in a polymeric waveguide is transmitted in discrete modes whose propagation orders depend on incident wavelength, waveguide dimensional parameters, and material properties. Diffracted optical structures are permittivity-modulated microstructures whose micro-relief surface profiles exhibit global/local periodicity. The resonant nature and location of such globally periodic structures (diffraction gratings) excite leaky waveguide modes which couple incident light into reflected/transmitted plane wave diffraction orders. It describes design & analysis, fabrication, and characterization of sub-wavelength polymer grating structures replicated in different polymeric materials (polycarbonate, cyclic olefin copolymer, Ormocomp) by a simple, cost-effective, accurate, and large scale production method. The master stamp (mold) for polymer replication is fabricated with an etchless process with smooth surface profile.",signatures:"Muhammad Rizwan Saleem and Rizwan Ali",downloadPdfUrl:"/chapter/pdf-download/61252",previewPdfUrl:"/chapter/pdf-preview/61252",authors:[{id:"227567",title:"Prof.",name:"Muhammad Rizwan",surname:"Saleem",slug:"muhammad-rizwan-saleem",fullName:"Muhammad Rizwan Saleem"},{id:"398554",title:"Dr.",name:"Rizwan",surname:"Ali",slug:"rizwan-ali",fullName:"Rizwan Ali"}],corrections:null},{id:"61296",title:"Applications and Solving Techniques of Propagated Wave in Waveguides Filled with Inhomogeneous Dielectric Materials",doi:"10.5772/intechopen.76793",slug:"applications-and-solving-techniques-of-propagated-wave-in-waveguides-filled-with-inhomogeneous-diele",totalDownloads:1026,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter presents techniques to solve problems of propagation along the straight rectangular and circular waveguides with inhomogeneous dielectric materials in the cross section. These techniques are very important to improve the methods that are based on Laplace and Fourier transforms and their inverse transforms also for the discontinuous rectangular and circular profiles in the cross section (and not only for the continuous profiles). The main objective of this chapter is to develop the techniques that enable us to solve problems with inhomogeneous dielectric materials in the cross section of the straight rectangular and circular waveguides. The second objective is to understand the influence of the inhomogeneous dielectric materials on the output fields. The method in this chapter is based on the Laplace and Fourier transforms and their inverse transforms. The proposed techniques together with the methods that are based on Laplace and Fourier transforms and their inverse transforms are important to improve the methods also for the discontinuous rectangular and circular profiles in the cross section. The applications are useful for straight waveguides in the microwave and the millimeter-wave regimes, for the straight hollow waveguide and for infrared field, also in the cases of inhomogeneous dielectric materials in the cross section.",signatures:"Zion Menachem",downloadPdfUrl:"/chapter/pdf-download/61296",previewPdfUrl:"/chapter/pdf-preview/61296",authors:[{id:"147585",title:"Dr.",name:"Zion",surname:"Menachem",slug:"zion-menachem",fullName:"Zion Menachem"}],corrections:null},{id:"61256",title:"Periodic Rectangular and Circular Profiles in the Cross Section of the Straight Waveguide Based on Laplace and Fourier Transforms and Their Inverse Transforms and Applications",doi:"10.5772/intechopen.76794",slug:"periodic-rectangular-and-circular-profiles-in-the-cross-section-of-the-straight-waveguide-based-on-l",totalDownloads:955,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter presents propagation along the straight rectangular waveguide with periodic rectangular and circular profiles in the cross section. The objectives in this study are to explore the effect of the periodic rectangular and circular profiles in the cross section of the straight waveguide on the output field and to develop the technique to calculate two kinds of the periodic profiles. The method is based on Laplace and Fourier transforms and the inverse Laplace and Fourier transforms. The contribution of the proposed technique is important to improve the method that is based on Laplace and Fourier transforms and their inverse transforms also for the discontinuous periodic rectangular and circular profiles in the cross section (and not only for the continuous profiles). The proposed technique is very effective to solve complex problems, in relation to the conventional methods, especially when we have a large numbers of dielectric profiles. The application is useful for straight waveguides in the microwave and the millimeter wave regimes, with periodic rectangular and circular profiles in the cross section of the straight waveguide.",signatures:"Zion Menachem",downloadPdfUrl:"/chapter/pdf-download/61256",previewPdfUrl:"/chapter/pdf-preview/61256",authors:[{id:"147585",title:"Dr.",name:"Zion",surname:"Menachem",slug:"zion-menachem",fullName:"Zion Menachem"}],corrections:null},{id:"59870",title:"A Theoretical Model of the Holographic Formation of Controllable Waveguide Channels System in Photopolymer Liquid Crystalline Composition",doi:"10.5772/intechopen.74838",slug:"a-theoretical-model-of-the-holographic-formation-of-controllable-waveguide-channels-system-in-photop",totalDownloads:806,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Rapid development of the integrated optics and photonics makes it necessary to create cheap and simple technology of optical waveguide systems formation. Photolithography methods, widely used for these tasks recently, require the production of a number of precision amplitude and phase masks. This fact makes this technology expensive and the formation process long. On another side there is a cheap and one-step holographic recording method in photopolymer compositions. Parameters of the waveguide system formed by this method are determined by recording geometry and material’s properties. Besides, compositions may contain liquid crystals that make it possible to create elements, controllable by external electric field. In this chapter, the theoretical model of the holographic formation of controllable waveguide channels system in photopolymer liquid crystalline composition is developed. Special attention is paid to localization of waveguides in the media caused by light field attenuation during the formation process.",signatures:"Artem Semkin and Sergey Sharangovich",downloadPdfUrl:"/chapter/pdf-download/59870",previewPdfUrl:"/chapter/pdf-preview/59870",authors:[{id:"226143",title:"Ph.D.",name:"Sergey",surname:"Sharangovich",slug:"sergey-sharangovich",fullName:"Sergey Sharangovich"},{id:"226145",title:"Dr.",name:"Artem",surname:"Semkin",slug:"artem-semkin",fullName:"Artem Semkin"}],corrections:null},{id:"59829",title:"Application of Numeric Routine for Simulating Transients in Power Line Communication (PLC) Systems",doi:"10.5772/intechopen.74753",slug:"application-of-numeric-routine-for-simulating-transients-in-power-line-communication-plc-systems",totalDownloads:830,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Applying numerical routines based on trapezoidal rule of integration (Heun’s method for numerical integration), simple models of transmission lines are used to analyze and simulate the propagation of communication signals in PLC-type systems (power line communication systems). Such systems are shared by the same systems for the transfer of electrical power and signal transmission. For the mentioned routines, the main objectives are: simulate the propagation of electromagnetic transients in these systems and analyze the interference of such phenomena in the transmitted signal. Such simulations are performed with classical structures that represent infinitesimal units of transmission lines. Modifications in the structure of such units are analyzed to improve the results obtained by the mentioned simulations.",signatures:"Afonso José do Prado, Luis Henrique Jus, Melissa de Oliveira Santos,\nElmer Mateus Gennaro, André Alves Ferreira, Thainá Guimarães\nPereira, Aghatta Cioqueta Moreira, Juliana Semiramis Menzinger,\nCaio Vinícius Colozzo Grilo, Marinez Cargnin Stieler and José\nPissolato Filho",downloadPdfUrl:"/chapter/pdf-download/59829",previewPdfUrl:"/chapter/pdf-preview/59829",authors:[{id:"148612",title:"Dr.",name:"Afonso",surname:"Prado",slug:"afonso-prado",fullName:"Afonso Prado"},{id:"148614",title:"Dr.",name:"José",surname:"Pissolato Filho",slug:"jose-pissolato-filho",fullName:"José Pissolato Filho"},{id:"239891",title:"Mr.",name:"Luis Henrique",surname:"Jus",slug:"luis-henrique-jus",fullName:"Luis Henrique Jus"},{id:"239892",title:"Ms.",name:"Melissa De Oliveira",surname:"Santos",slug:"melissa-de-oliveira-santos",fullName:"Melissa De Oliveira Santos"},{id:"239893",title:"Dr.",name:"Elmer Mateus",surname:"Gennaro",slug:"elmer-mateus-gennaro",fullName:"Elmer Mateus Gennaro"},{id:"239894",title:"Dr.",name:"André",surname:"Ferreira",slug:"andre-ferreira",fullName:"André Ferreira"},{id:"239895",title:"Ms.",name:"Thainá Guimarães",surname:"Pereira",slug:"thaina-guimaraes-pereira",fullName:"Thainá Guimarães Pereira"},{id:"239896",title:"Ms.",name:"Aghatta Cioqueta",surname:"Moreira",slug:"aghatta-cioqueta-moreira",fullName:"Aghatta Cioqueta Moreira"},{id:"239897",title:"Ms.",name:"Juliana Semiramis",surname:"Menzinger",slug:"juliana-semiramis-menzinger",fullName:"Juliana Semiramis Menzinger"},{id:"239898",title:"Mr.",name:"Caio Vinícius Colozzo",surname:"Grilo",slug:"caio-vinicius-colozzo-grilo",fullName:"Caio Vinícius Colozzo Grilo"},{id:"239899",title:"Dr.",name:"Marinez",surname:"Cargnin Stieler",slug:"marinez-cargnin-stieler",fullName:"Marinez Cargnin Stieler"}],corrections:null}],productType:{id:"1",title:"Edited 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Renna, Rodrigo Garcia, Jesica Ramirez and Roberto M.\nMiatello",dateSubmitted:"May 26th 2016",dateReviewed:"January 16th 2017",datePrePublished:null,datePublished:"April 5th 2017",book:{id:"5682",title:"Physiologic and Pathologic Angiogenesis",subtitle:"Signaling Mechanisms and Targeted Therapy",fullTitle:"Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy",slug:"physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy",publishedDate:"April 5th 2017",bookSignature:"Dan Simionescu and Agneta Simionescu",coverURL:"https://cdn.intechopen.com/books/images_new/5682.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"66196",title:"Dr.",name:"Dan",middleName:"T.",surname:"Simionescu",slug:"dan-simionescu",fullName:"Dan Simionescu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"192616",title:"Dr.",name:"Nicolás",middleName:null,surname:"Renna",fullName:"Nicolás Renna",slug:"nicolas-renna",email:"nicolasfede@gmail.com",position:null,institution:{name:"National University of Cuyo",institutionURL:null,country:{name:"Argentina"}}},{id:"202536",title:"Dr.",name:"Rodrigo",middleName:"Damián",surname:"García",fullName:"Rodrigo García",slug:"rodrigo-garcia",email:"rodridg@hotmail.com",position:null,institution:null},{id:"202537",title:"Dr.",name:"Jesica",middleName:null,surname:"Ramirez",fullName:"Jesica Ramirez",slug:"jesica-ramirez",email:"jesicamagali@hotmail.com",position:null,institution:null},{id:"202539",title:"Dr.",name:"Roberto M.",middleName:null,surname:"Miatello",fullName:"Roberto M. Miatello",slug:"roberto-m.-miatello",email:"rmmiatello@gmail.com",position:null,institution:null}]}},chapter:{id:"54438",slug:"vascular-repair-and-remodeling-a-review",signatures:"Nicolás F. Renna, Rodrigo Garcia, Jesica Ramirez and Roberto M.\nMiatello",dateSubmitted:"May 26th 2016",dateReviewed:"January 16th 2017",datePrePublished:null,datePublished:"April 5th 2017",book:{id:"5682",title:"Physiologic and Pathologic Angiogenesis",subtitle:"Signaling Mechanisms and Targeted Therapy",fullTitle:"Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy",slug:"physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy",publishedDate:"April 5th 2017",bookSignature:"Dan Simionescu and Agneta Simionescu",coverURL:"https://cdn.intechopen.com/books/images_new/5682.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"66196",title:"Dr.",name:"Dan",middleName:"T.",surname:"Simionescu",slug:"dan-simionescu",fullName:"Dan Simionescu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"192616",title:"Dr.",name:"Nicolás",middleName:null,surname:"Renna",fullName:"Nicolás Renna",slug:"nicolas-renna",email:"nicolasfede@gmail.com",position:null,institution:{name:"National University of Cuyo",institutionURL:null,country:{name:"Argentina"}}},{id:"202536",title:"Dr.",name:"Rodrigo",middleName:"Damián",surname:"García",fullName:"Rodrigo García",slug:"rodrigo-garcia",email:"rodridg@hotmail.com",position:null,institution:null},{id:"202537",title:"Dr.",name:"Jesica",middleName:null,surname:"Ramirez",fullName:"Jesica Ramirez",slug:"jesica-ramirez",email:"jesicamagali@hotmail.com",position:null,institution:null},{id:"202539",title:"Dr.",name:"Roberto M.",middleName:null,surname:"Miatello",fullName:"Roberto M. 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In order to be effective, herbicides must overcome a variety of barriers (morphological, biological, and environmental) to their entry into plants. For example, trichomes on the leaf surface can reduce herbicide efficacy by intercepting spray droplets before they contact the epidermal surface [11]. Environmental stress (e.g., hot, dry weather) may develop a thicker than normal wax layer, or increase other defensive structures such as reducing the plant’s metabolic and transport processes that are required for adequate weed control.
Because of these reasons, adjuvants have been developed to assist herbicides, in that they:
Allow better mixing and handling with herbicide active ingredient [12]
Reduce or even eliminate spray application problems [13] (e.g., drift reduction) [14,15]
Allow contact to the weed target, increase droplet coverage, spray retention, and droplet drying [16,17]
Increase herbicide cuticle penetration and cellular accumulation [18,19]
Significantly enhance and improve an herbicide’s efficacy so that the concentration or total amount of herbicide required to achieve a given effect is reduced [20-26]
Decrease the amount of herbicide applied and lower total costs for weed control [27,28]
Enhance the formulation’s ability to kill the targeted species without harming other plants [29]
From an environmental aspect, can reduce leaching of herbicide through the soil profile [30,31]
However, it is important to note that in some circumstances, adding adjuvants will not significantly improve control [32]. Sometimes adjuvants can have negative effects, such as:
The history of adjuvants in agriculture dates back to the 18th and 19th centuries when additives such as resins, tar, flour, molasses, and sugar were used with lime, sulfur, copper or arsenates to improve adherence and biological performance of active ingredients by modifying the physicochemical properties of the spray solution [40].
The first agricultural adjuvant was a soap solution (Gillette 1888, 1890) (cit. by Hazen, [41]). Soap solutions and kerosene were used in the United States to kill insect eggs or were added to arsenical solutions to increase toxicity to weeds [42]. Animal oil soaps were common adjuvants in use before 1900, as well (Gillette1889) (cit. by Hazen, [41]). They were derived from animals, fish, and whale oil and were used to enhance the pesticide performance. Sugars and glue were considered as stickers and many other materials followed as adjuvant research continued [43].
The modern era of synthetic organic pesticides began in the 1930s. The research behind medical (including antibiotics) and military uses funded research that led to the discovery of many pesticide families that are still in use today. An initial breakthrough in weed control occurred with the introduction of 2,4-D in the 1940s for broad-spectrum broadleaf weed control in corn and cereal crops [44]. Soaps and mineral oils were replaced by nonionic surfactants. Nitrogen fertilizers like ammonium sulfate (AMS) and urea ammonium nitrate (UAN) were also used to enhance the herbicidal activity while glycerin was introduced as humectant.
In the 1960s and 1970s, modern types of adjuvants such as crop oil concentrates (COC) were developed, which were used to reduce doses of atrazine and to lower spray volumes. Organosilicone-based adjuvants, nonionic surfactants (NIS), which have excellent wetting and spreading capability and enhance the penetration of post-emergent herbicides, were developed later [45].
There are over 3,000 adjuvants available for use. These can be grouped into three general types:
Activators,
Spray modifiers and
Utility modifiers
Activators modify certain herbicide characteristics, including particle size and viscosity of the herbicide spray, evaporation rate, etc. Usually, they increase herbicide activity, herbicide spread, absorption into plant tissue, and rainfastness, and decrease photodegradation of the herbicide.
There are three categories of activators: surfactants, wetting agents, and oils.
Surfactants (SURFace ACTive AgeNTS) are a type of activators designed to improve the dispersing/emulsifying, absorbing, spreading, wetting, sticking, and/or penetrating properties of the spray mixture [6]. Surfactants primarily influence the ability of herbicides to penetrate the leaf\'s waxy cuticle. Most herbicides are prepared in a solution of water. Water is a chemically polar material and thus can be repelled by the waxy surface of leaves. Water containing a surfactant reduces the surface tension of water on plants, spread in a wet thin layer over a waxy leaf surface, and allow the herbicide formulation to enter into the plant.
Surfactants can be classified in four groups on the basis of the ability to ionize the aqueous solution. Those groups are:
Nonionic — are the most commonly used in agriculture and can be mixed readily with any herbicide. They produce little or no ionization in water (no electrical charge). Organosilicone and silicone surfactants are two types of nonionic surfactants.
Cationic — are not often used with herbicides. They have a positive charge,
Anionic — rarely used with herbicides, but mainly used in cosmetics, household cleaners, many domestic detergents, etc. They have a negative charge, and
Ampholytic (amphoteric) — have a both positive and negative charge, that is, in aqueous solution are capable forming cations or anions.
Wetting agents increase the ability of water to displace air or liquids from the leaf surface, allowing it to be wet by the herbicide. Wetting agents help spread the solution more evenly over the leaf.
Oils increase the retention time of a solution on leaves, allowing for an increase in herbicide uptake. Oils mostly contain emulsifiers to allow them to mix with water. Some claims regarding oils include reduced rainfast periods, more uniform droplet size (drift reduction), less spray evaporation, and better penetration of herbicide into waxy leaves.
All oils are basically mineral oils with different contents of surfactant in formulation (3%--20%). They can be classified as:
Crop oils
Dormant oils
Crop oil concentrates
Vegetable oils
Vegetable oil concentrate
Modified vegetable oil, and
Modified vegetable oil concentrate
Crop oils are emulsifiable petroleum oil-based products containing up to 5% w/w surfactant and the remainder of phytobland oil.
Dormant oils are horticultural spray oils applied during the dormant phase of the targeted plant [2]. There are ‘‘quick-break’’ or dormant oils that use a very low amount (2%--5%) of emulsifier for dispersion into the spray tank [41].
COC are the most commonly used oils in agriculture. They were introduced to the market in the 1960s [45]. COC are emulsifiable petroleum oil-based products containing 5%--20% w/w surfactant and a minimum of 80% w/w phytobland oil [2]. COC enhanced activity of aryloxyphenoxy propionates, cyclohexadinones, triazines, phenoxy acid urea herbicides, imidazolinones, etc. [46,47,26].
Vegetable oils are also used as herbicide adjuvants. The base in formulation is oil from sunflower, soybean, oilseed rape, peanut, or corn, which is combined with surfactants in different content.
Vegetable oil concentrates are emulsifiable vegetable oil products containing 5%--20% w/w surfactant and a minimum of 80% w/w vegetable oil [2]. There are some vegetable oil concentrates used in the same manner as the crop oil concentrates, typically based upon canola or soybean oil, using 5%--10% emulsifier for dispersion [41].
Modified vegetable oil is oil extracted from seeds that have been chemically modified. Methylated seed oils (MSO) are vegetable oils mainly from oilseed rape or sunflower esterified with alcohol ethanol to get methyl esters.
Modified vegetable oil concentrate is an emulsifiable, chemically modified vegetable oil product containing 5%--20% w/w surfactant and remain chemically modified vegetable oil. Some of the best vegetable-based products are those modified (derivatized) to methyl and other lower alkyl esters such as methylated soybean oil, methyl sunflowerate, or ethyl canolate.
Spray modifiers affect the delivery and placement of the spray solution. They confine or alter the physicochemical characteristics of the spray solution [48], and make the herbicide spray easier to aim, reduce herbicide drift in the air, and cause the spray to more readily adhere to the plant. Spray modifiers include:
Thickening agents (i.e., invert emulsions and polymers)
Stickers
Spreaders
Spreader-stickers
Foaming agents
Humectants, and
UV absorbents
Thickening agents modify the viscosity (thickness) of spray mixtures. They control drift or slow evaporation after the spray has been deposited on the target area. Slowing evaporation is important when using systemic herbicides, because they can penetrate the plant cuticle only as long as they remain in solution. Invert emulsions, polymers, and
Invert emulsions are mixtures of inverting oil and water, having a mayonnaise-like appearance on the water surface and a snowflake-like appearance under the water surface. Depending on their solubility, herbicides dissolve in either the oil or water component. The oil in the case of
Polymers are a very large, chain-like carbon molecules made up of monomers, up to 40,000 carbons in length, forming a thick mucus-like material which helps to break the surface tension of water and enhance sinking of herbicides [50,51].
Drift control agents modify spray characteristics to reduce spray drift, usually by minimizing small droplet formation. They are generally polyacrylamide or polyvinyl polymers [52].
Stickers assists the spray deposit to adhere or stick to the the leaf surface and may be measured in terms of resistance to time, wind, water, mechanical action, or chemical action [2]. Stickers may be heavy petroleum fractions, water-soluble polymers, acrylic latex, epoxidized seed oils (similar to boiled linseed oil, which dries on exposure to air), or alkylphenol condensates called resins. Stickers are commonly used in field crops (like corn and soybeans) where residue on leaves is not a problem. They are usually used for application of fungicides and insecticides rather than herbicides.
Spreaders are compounds that cause the surface tension of the herbicide to be reduced in such a way that it easily spreads into a very thin film over a leaf surface. Spreaders increase the efficiency of the herbicide dramatically. Typically, the alcohol ethoxylates [53] such as tridecanol ethylene oxide allow a spread diameter increase of two to three times. They may contain fatty acids, latex, aliphatic alcohols, crop oils such as cottonseed, or inorganic oils.
Spreader-stickers are essentially combinations of stickers and spreaders. They provide additional retention of herbicide in wet conditions. They are usually used with contact insecticides and fungicides for which complete coverage is critical.
Foaming Agents are compounds that facilitate formation of foam for reducing drift and evaporation. These agents are used infrequently for drift control of herbicide applications.
Humectants, like stickers, increase the amount of time that the herbicide is on the leaf, in a form available for uptake [41]. When water evaporates from the spray droplet and the herbicide becomes a crystalline residue, it is no longer available for uptake into the leaf. Humectants keep the spray deposit moist and in true solution, and therefore extend the time that it is available for absorption [54].
UV absorbents protect herbicides from the deleterious effect(s) of sunlight. They may do this by either physical or chemical processes, such as by increasing the rate of herbicide uptake into the cuticle, or by absorbing the UV-light themselves.
Utility modifiers help minimize handling and application problems. They do not directly improve efficacy, but widen the conditions when an herbicide can be used or maintain the integrity of the spray solution. For example, utility modifiers reduce foaming, increase solubility, modify pH, or reduce spray drift.
Types of modifiers include emulsifiers, dispersants, stabilizing agents, coupling agents, co-solvents, compatibility agents, buffering agents, antifoam agents, and ammonium fertilizers.
Emulsifiers are molecules with one hydrophilic and one hydrophobic end. They make it possible for water and oil to become finely dispersed in each other, creating a stable, homogeneous, smooth emulsion. Most crop oils contain emulsifiers to allow them to mix with water and some contain various levels of surfactants.
Dispersants are chemicals that are sprayed on a surface oil slick to break down the oil into smaller droplets that more readily mix with the water. These water soluble dispersants have been found to be unique and highly effective dispersants for water insoluble agricultural suspension concentrate formulations.
Stabilizing agents act as thickening or gelling agents that increase the viscosity of the final product. These agents stabilize emulsions, either by adsorbing to the outer surface of oil droplets. Stabilization can be achieved in agricultural suspension and emulsion through the use of fine-particle-size solids and fine liquid droplets in the disperse phase along with appropriate dispersants and wetting agents.
Coupling agents are compounds which provide a chemical bond between two dissimilar materials, usually an inorganic and an organic. Organosilanes are well-suited in this application because of the ability to incorporate an organic-compatible functionality and an inorganic-compatible functionality within the same molecule.
Cosolvents are defined as water-miscible organic solvents that are used in liquid herbicide formulations to increase the solubility of poorly water-soluble substances or to enhance the chemical stability of an herbicide.
Compatibility agents allow simultaneous application of two or more ingredients. They are most often used when herbicides are applied in liquid fertilizer solutions.
Buffering agents are used to change the pH and hardness of the water and to increase the dispersion or solubility of herbicides in alkaline or acid waters used in making up an herbicide solution. Ammonium sulfate (AMS) is sometimes added to reduce hard water problems.
Antifoam agents reduce foaming in spray mixtures that require vigorous agitation. They are particularly useful in soft water. Antifoam agents are usually siliconebased and used at 0.1% or less of the total spray volume [55].
Ammonium fertilizers are often added to spray solutions with foliar applied herbicides. The two most common ammonium fertilizers used are ammonium sulfate (AMS) and urea ammonium nitrate (UAN) solution (28-0-0). The exact mechanism of action for ammonium fertilizers is not known although increased herbicide uptake into plant has been reported [26].
Surfactants are the most widely used and probably the most important of all adjuvants [56]. They can be especially effective in improving the biological activity of many herbicides [57-59]. Nonionic surfactants (NIS) improved the effect of nicosulfuron [58] and enhanced glyphosate absorption, which was 20 times greater and the spread of spray drop was 200 greater than with no adjuvants added [60].
Several researchers have observed that adjuvant efficacy is dependent on the herbicide being applied and the characteristics of the target weed species [61-63]. For example, MSO increase foliar absorption and efficacy of many herbicides, including primisulfuron, rimsulfuron, imazethapyr, quinclorac, and several graminicides for grass weed control [21,64-66]. MSO was the only adjuvant used with foramsulfuron that provided acceptable giant foxtail control (
NIS have been effective in improving the activity of several sulfonylurea herbicides, including primisulfuron, rimsulfuron, and thifensulfuron, as well [57,58,68]. MSO and COC have been shown to further enhance the effectiveness of several herbicides on certain weed species, including nicosulfuron [23]. These adjuvants enhanced the effectiveness of chlorimuron and imazethapyr on purple nutsedge (
The addition of AMS or UAN to the spray solution can enhance herbicide effectiveness by further increasing herbicide absorption [26,72] which gives better result up to 12%--13.5% than use of herbicide alone [73]. For instance, thifensulfuron absorption into velvetleaf (
Considering environmental factors, rain shortly after an herbicide application is one of the most detrimental issues for herbicide performance. Adjuvants have been shown to improve the rainfastness of herbicides and the effect on rainfastness should be considered when selecting an adjuvant [90,91]. A number of studies have been published that outline the beneficial effects of OSL adjuvants in reducing the critical rain-free period after the foliar herbicidal application. Field and Bishop [92], Reddy and Singh [93], and Roggenbuck
Studies with 14C-labeled glyphosate have demonstrated that plants absorb as little as 22% of the amount applied; however, the addition of surfactant improved absorption up to 35% [94]. For instance, the OSL adjuvants produced rapid absorption of the 14C-glyphosate into the redroot pigweed (
In contrast to surfactants, water repellent adjuvants increase surface tension, thus inhibiting wetting of the leaf surface. The water repellent DC 1-6184 may have some utility for reducing corn injury when isoxaflutole is applied to corn foliage at early growth stages [99]. These results are consistent with the observation of Nelson and Penner [100] that DC 1-6184 applied in combination with herbicide safener R-29148 and isoxaflutole reduced injury to spike-stage corn (28%) as compared with isoxaflutole applied alone (53%) or isoxaflutole applied with only R-29148 (37%). Penner and Fausey [101] found that DC 1-6184 consistently reduced retention of flumioxazin spray on plant foliage by increasing the number of droplets that bounced off the foliage. Flumioxazin spray had the greatest retention of all herbicide treatments on tomato when DC 1-6184 was included. Also, the same water repellent, DC 1-6184, reduced isoxaflutole retention on tomato, wheat, and cabbage [100].
From an environmental aspect, adjuvants can weakly bind herbicides and release them slowly in order to prolong the efficacy of herbicides and to minimize their leaching into groundwater. Enersol 12% adjuvant resulted in a 13%–18% reduction in leaching of dicamba and bromacil in five pore volumes of leachate. The leaching of simazine was significantly decreased when charcoal, three humic substances (Enersol SP 85%, Enersol 12%, and Agroliz), and a synthetic polymer (Hydrosorb) were used. However, the decrease in leaching was significantly greater when using Enersol SP 85% or Enersol 12% (24%–28%) than when using the other adjuvants (12%–16%) [30]. In a study by Locke
In many situations, as mentioned earlier, adjuvants can significantly enhance an herbicide’s effect [25]. However, it is important to note that in some circumstances, adding adjuvants will not significantly improve control. For example, several studies have shown that the addition of AMS to herbicides increases the control of
Sometimes adjuvants can decrease the killing power of the herbicide (antagonistic effects). The efficacy of sethoxydim or clethodim on large crabgrass [
Some adjuvants can increase harmful effects to non-target plants. Imazamox applied at 108 g/ha plus 1% (v/v) MSO applied in the fall consistently injured all wheat cultivars more than the same rate with NIS at 0.25% and 54 g/ha imazamox regardless of adjuvant and timing [37]. Injury caused by these treatments ranged from 23%to 70% for all cultivars. Adjuvant affected cotton injury from CGA 362622. NIS resulted in increased cotton injury at 29%, whereas COC increased cotton injury to 37%. [110]. Crooks
Sometimes adjuvants can have negative effects, such as increasing the formulation’s ability to spread or persist in the environment where it is not wanted. According to Kucharski and Sadowski [113], the addition of adjuvants caused an increase of the residues of active ingredients in the soil and roots of sugar beet compared to plots with a reduced dose of herbicide without adjuvants. Swarcewicz [114] and Swarcewicz
The agricultural adjuvants market, in terms of value, is projected to reach $3,183.04 million by 2019, at a CAGR of around 5.6% from 2014 [115]. Numerous factors such as, easy application, modern production practices, new product offerings, increased availability, increasing infestation of pests and diseases, and government regulations to protect the environment from hazardous chemical usage are the major drivers of the agricultural adjuvants market. Adjuvants are quietly helping to revolutionize the agrochemical business as they are the best tools for farmers to improve application, facilitate the right dosage, and achieve more cost-effective, better targeted, and environmentally acceptable pest control. Agricultural adjuvants play an essential role in the performance of most herbicides, fungicides, and insecticides, and function by transforming the dosage from preventative, high-dose applications to low dosages, specifically targeted for curative applications.
From all previous research mentioned, it can be concluded that the herbicide-adjuvant--plant-environment interaction is a complex system. Understanding the different roles of adjuvants in the behavior of herbicides is essential for their optimum utilization. Adjuvants can improve the biological activity of the herbicide active ingredient, the performance of the spray application, and the economics of herbicide applications, but in some circumstances adjuvants can manifest negative effects. Therefore, there is no universal adjuvant that can improve the performance for all herbicides, against all weeds, or under all environmental conditions. The herbicide and adjuvant selected and the relative amounts used must be tailored to the specific conditions of each application.
Regardless of the quantities harvested, the average percentage of virgin olive oil of the highest category (EVOO) in the three main producing countries, Spain, Italy, and Greece, is estimated at about 50% per year [EC Statistics, 1998]. The remainder has chemical or sensory defects that, depending on their intensity, must be classified as virgin olive oil (VOO), ordinary virgin olive oil (OVOO), or lampante virgin olive oil (LVOO) according to EEC-Regulation 2568/91 or International Olive Council (IOC) Standard. Olive oil is one of the most controlled vegetable oils in the world. Nevertheless, the EU classified olive oil as one of the most adulterated food products, although it is subject to a number of EC regulations [1].
Olive oil is one of the few fruit oils, along with avocado oil and palm oil. Most vegetable oils known to us are seed oils. The olive fruit goes through many important steps on its way “from tree to bottle” that can affect its quality. The fruit itself belongs to a range of well over 500 different varieties. They differ in the size of the fruit, size and type of leaves, ripening, kernel/pulp ratio, amount of oil, unusual minor components, and among other things, especially in taste. Some varieties are used only as table olives, others for both purposes, but most are processed into oil. In the plantations, the olive trees are planted traditionally, intensively, and super intensively. The spacing between trees has decreased from 7.50 × 7.50 m (traditional) to 3.50 × 3.50 m (intensive) to trellis-like cultivation as in the case of wine (super intensive). The main reasons for this type of cultivation are an improvement in yield and the use of harvesting machinery. Harvesting is the most expensive part. The most important factor for a good-quality oil is the right time of harvesting or the optimal ripeness of the fruit. After harvesting, the quality of the fruit can only decrease, as fermentative degradation processes begin immediately after harvesting. Picking the olives by hand is often the only way to harvest the fruit, as the cultivated areas make it impossible to use harvesting machines. It is important that the fruit is not damaged during harvesting, and the waiting time before pressing or extraction in the decanter should not exceed 24–48 hours. Pressing requirements range from high quantities of olives in a correspondingly short time to achieving a particular quality—regardless of quantity—with pressing temperatures or conditions during extraction in the decanter, high polyphenol content, and excellent aroma and flavor.
Ultimately, each of the above processing steps results in a wide range of different qualities in terms of aroma (smell and taste), complexity, nutritional composition, and oxidation stability.
When the oil is ready for marketing, each producer follows his own way of marketing. Depending on the size of the crop, some producers handle storage, bottling, labeling, and marketing themselves. For other producers, local cooperatives handle the larger quantities of oil. In many cases, there are buyers, brokers, and sellers who sell or buy large quantities to large bottling companies in the producing countries. These producing and bottling companies work for large food chains in Europe and around the world. Up to 80% of EVOO is sold as so-called “private labels” in discount stores and large grocery chains, at least in Europe (Figure 1). However, where large volumes are marketed, the trade tries to buy the oils at a minimum price. Inevitably, quality can suffer as a result, especially for EVOO grades marketed as part of so-called borderline oils. These include really bad tasting and sometimes slightly defective oils, which consequently would have to be officially retested to get clarity for the classification.
80% of EVOO is sold as “private label” to supermarkets and discounter chains.
The views of market participants and consumers must be differentiated, with the question of supply and demand and the requirements for quality and price in the foreground. In the various countries, the share of olive oils in the different categories varies greatly. There are countries where on average 80% EVOO and only 20% VOO and OO are consumed. In other countries, it is even only 30% EVOO and 70% virgin olive oil, refined olive oil, and olive pomace oil. The classification is carried out by the legislator within the framework of a marketing regulation. The classification is based on the data of chemical and sensory analysis (Figure 2). Although the technology of oil extraction (pressing, malaxation [2], decantation), the climatic conditions, and the possibilities of chemical analysis have changed considerably in the last 30 years, there have been only minor adjustments to the legal regulations in this respect—especially with regard to the chemical control parameters. The classification is granted on the basis of the 1991 regulations in force, if the chemical analysis (officially 27 parameters) meets the requirements and the sensory test in the so-called panel test (PT) have been passed. The PT is performed by a regional, national, EC, or IOC accredited official panel of 8–12 trained olive oil tasters. It is used to verify conformity with the requirements of Regulation (EC) 2568/91, as amended [1]. Before receiving EC approval, panels must be accredited according to EN ISO 17025 (2018) and require approval by national authorities [3] and subsequently by the European Commission. The methodology and range of requirements for sensory evaluation are also defined by the International Olive Council (IOC) [4].
IOC/EC-organoleptic criteria for olive oil classification [
Based on the panel test, the classification of the olive oil is done without prejudice to possible unauthorized material changes of the oil such as thermal posttreatment (adulteration), which cannot be detected in the panel test [5]. The aim of the panel test is the qualitative detection of negative attributes as well as positive attributes such as fruitiness (plus green-fruity or ripe-fruity), bitterness and pungency, and their quantification. The individual results of the panelists are statistically evaluated in order to obtain a sensory result that is valid and as objective as possible.
According to the currently valid criteria of the Regulation, samples that show a median for the negative attributes of “0” and also show a low fruitiness of only around 1.2 are already classified as “extra virgin.” Olive oils with a fruitiness intensity of more than 5 until 7 or 8 receive the same classification. In the case of sensory defects, a distinction is also made according to the intensity of the defects. If the median for a sensory defect is between 2.5 and 3.4 in intensity, the oil still belongs to the VOO category. But if it is a rancid defect, the oil becomes the grade lampante virgin olive oil (LVOO) in a couple of weeks or months. Generally, the consumer cannot tell from the name “virgin” that this oil has a defect such as fusty or rancid. The consumer thinks more of a lower quality than of a real defect or a bad taste without being aware of the risk of spoilage. According to the current food regulations in the EC, such foodstuffs have to be labeled accordingly. In our eyes, this is a weakness of the IOC Method No. T20, No. 14/2021 or Reg. (EEC) 2568/91 in its current version, that all olive oils classified as EVOO (on an annual average more than 1.2 million tons) belong to the highest quality segment in the sense of the regulation. EVOO is not a consumer product such as pasta, milk, or potatoes; it is a food ingredient and can in many ways turn cold, hot, or warm dishes into a delicious (and nutritious) experience or even spoil in case of a sensory error. Due to its unique organoleptic properties, it requires a more objective overall assessment, including differentiation in quality that is more recognizable to the consumer, in addition to its classification.
An adequate approach in order to achieve more differentiation in the category of EVOO, it was found in olive oil competitions organized mainly for premium olive oils. These competitions are not subject to any official regulation but are initiatives of national associations and organizers such as the IOC for the Mario Solinas Competition [6]. In the new test sheet for this competition, the parameter harmony has to be evaluated three times (olfactive, retronasal/gustatory, and global). With all due respect to olive oil competitions, it should be noted that the IOC holds a demanding annual competition for practically less than 2% of the EVOO produced worldwide. In these kinds of competitions, the producers are awarded with gold and silver medals, certificates, and recommendations. The result is valuable top-quality oils, tasty delicacies with a high content of healthy fatty substances [7]. But because not all olives of a producer can be picked in one day and because nature does not wait for olives to ripen continuously, in most cases, only smaller quantities of these high-value oils are available to about 15–20% of the somewhat better-off consumers. These awards are only given for exceptional commitment on the part of the producers, which work with extraordinary engagement down to the last detail. Accidentally, for the remaining rest of 98% (!) of the EVOO, no qualitative distinction is foreseen although even these oils have different, more or less characteristic flavors.
Unfortunately, the consumer’s knowledge of olive oil is not very common. Generally the consumer is unable to differentiate between terms such as varieties [8], cold-extracted, virgin or extra virgin, acid values. This is exploited by the trade in many countries and tolerated or supported by the legislator. Below the top qualities, there is no differentiation any more apart from mainly emotional arguments. Especially in this more affordable but very important mass market segment—which means for 80% of the consumer—a better differentiation is needed. It would help more consumers to gain confidence in a somewhat more expensive but recommendable oil.
The trade is dominated by price competition that often ignores quality aspects. For example, the 2015 IGO study [9] showed that out of 70 rather cheap samples from 15 different EU countries intentionally labeled as Extra Virgin, only 41.4% (29/70) could be confirmed as EVOO. 58.6% (41/70) had to be downgraded to the VOO category. The origin of the samples was reported as 58% EU blend, 23% Spanish blend, and 9% Italian blend.
Unlike food from certain countries such as honey or wine, olive oils from one country can be blended with oils from other countries within the EU and marketed as EU-Blends. The publication “EU-Blend” on the label is obligatory in such cases as well as all other origins from EVOO. The consumer must pay close attention to labels, including the brand name, as it is now mandatory to provide information on the label about the actual origin of the oil. Despite the wealth of information, many consumers lose their bearings and trust their personal shopping source more.
Regardless of this fact, we still assume that a not insignificant percentage of the oils sold worldwide as EVOO actually belong more to the VOO category due to sensory deficiencies. Some manufacturing companies simply refer to this type of EVOO as “borderline” EVOO. A practice that unfortunately cannot be ruled out is that olive oils with slight sensory defects are blended with extra virgin olive oils in such a way that the defects are very difficult to detect in a panel test. This means that for this type of EVOO in different panel tests (PT) different results such as VOO or EVOO can arise. The unofficial trade-declaration “borderline” depends on the requests of local stakeholders and the willingness of some suppliers, especially in those countries where the food control for olive oil is not yet so developed.
The German Olive Oil Panel (DOP), established in 1999 as a “virtual” panel [10] with the approval and support of the IOC, addressed the issue of different qualities within the EVOO category. The DOP was recognized by the IOC from 2001 to 2005 [11]. Since 2007, the DOP has been accredited according to EN ISO/IEC 17025 [3]. From 2011 to 2021, it is recognized by the German authorities, the European Commission, and the IOC [12].
The IOC has defined several guidelines and instructions for organoleptic assessment, which are continuously adapted. They include methodological aspects such as the necessary number of tasters (8–12), the basic vocabulary, the use of the profile sheet, test glasses, booth, etc. All details are described in depth in the IOC standards T20 No.14/2021 [4] and Reg. (EC) 2568/91 in their current version [1].
As mentioned in Chapter 1.2 of the introduction, the Panel test (PT) result in the European Union and third countries is only used to classify whether the oil is “extra virgin,” “virgin” (“ordinary”), or “lampante.” This study is concentrating on those samples only which gained the classification extra virgin.
The idea to extend the official sensory evaluation of olive oil was developed in the DOP by the panel leader Dieter Oberg already in 2003 in order to further differentiate the quality within the highest category “extra virgin.” For this purpose, it was necessary to extend the sensory test and as a consequence as well the profile sheet. A further parameter “harmony” was added at the end of the sheet analogous to the testing in many olive oils competitions. The official criteria defects, fruitiness, bitterness, and pungency remain unchanged. The tester follows the Reg. of EC/IOC for the result for the classification. But then it has to be decided for one additional but very important parameter “harmony” (QHV) in the same session.
The new QHV method [13] shows a mark in the middle of the additional line on the profile sheet (Figures 3 and 4), which indicates the mark “5” to the taster. Around this mark is a standard quality in the sense of an average quality or the cheapest offer often found in German supermarkets and discounters. A quality without sensory defects, but with a decent average in terms of character, flavor, or pleasant persistence, for example. Only 15–30% of the EVOO in the world reach values of more than 5.5 in the harmony scale. Values of more than 7 are only achieved by qualities, which are in a range of premium products. On the left side from the value “5” between 3.5 and 4.5, one finds oils with a sensory profile, which is “not sufficient” until “bad”—depending on if a panel did not decide for a median of defect. Many of the so-called borderline oils are further left around 2.8–3.8. Oils with a recognizable sensory defect are only rated around 3 and, depending on the intensity of the defect, even lower or 0. Finally, it is the PSV who can along the results of the panel test decide if a median for a defect is reached and then will set the factor harmony to “0.” In the training of tasters, the new criterion of harmony attempts to distinguish the fruitiness of an oil not only as present or absent, ripe or green. Now, for example, the differences between the olfactory impression (clean, clear, or less) and the subsequent taste impression (harmonious or strange, unexpectedly good in the sense of the relevant criteria or not) are additionally included in the quantified result for harmony. The tasters are asked as well to recognize particular aromas in olive oils. Aromas appear to the taster as the scent of a large bouquet of flowers or as clearly recognizable individual aromas of certain leaves, fruits, vegetables, or spices. Beyond this, the persistence and mouthfeel of the sensory impression create an overall impression in the taster, which is then translated numerically. This requires a special training of the tasters, as they are not limited any more to the official criteria such as fruity-bitter-pungent but can recognize additional sensory characteristic aspects of an oil, similar to wine. There are more than 500 olive varieties [8] grown in different ways in more than 20 countries. The goal is to produce oils with a certain sensory profile, even below the premium class. Only the additional criteria of harmony can fulfill this ambition.
Excerpt from the profile sheet with additional line for harmony evaluation.
Rough division of the red curve (enlarged) of
The official methodology for determining the QHV value includes four steps, which are described below and can be trained and performed using the feature-benefit formula in Figure 5. The feature-benefit diagram is a path on the way to the decision for a certain value for the taster’s QHV. The taster is referred to all four additional sensory characteristics (A–D) to be evaluated, can roughly tick the differently strong or less strong expression of the individual criteria, and thus arrive at a quantified overall result, which will be sent to the PSV.
The first impression of the fruitiness via nose is the basic for purity and diversity of elements, which includes already the intensity. It feeds expectations for a similar retronasal impression. The second impression via palate (retronasal) can match the impression (plus/minus) or the taster has an unexpected impression with positive or negative olfactive elements.
This balance increases if at the end bitterness and pungency are in a balanced relation to the fruitiness—preferably with a long persistency. Less balance means if bitterness or pungency is too dominant, and the positive impression of the fruitiness is more or less disturbed. The decision for the intensity of bitterness and/or pungency needs time.
A sample can offer more positively a diversity of aromas in different intensities or just one single aroma—also in a lower intensity. A sample gives more negatively the impression of not clearly to defined aromas and/or aromas, which have not a perfect purity or not clear to defined aromas. Some aromas can be detected retronasal only.
Complexity increases with the number/intensities of aromas and the flavor.
A long and pleasant persistency of the flavor is positive.
A more long texture is more positive than a short texture.
Feature/benefit chart as an aid to getting started with the decision way for the additional QHV.
A rough description of an example: The tester decides for A with +, for B with +, for C with -, for D with ±. In the “Quantification” column of this theoretical sample, the tester first might decide mentally on the range “around 5” and then his final score 4.8. He enters this result on the profile sheet and passes it on to the PSV. Admittedly, a tester’s decision for a QHV quality “not sufficient, “upper standard,“ or “very good“ is as exact as a decision for the intensity of fruitiness or a defect. Ultimately, homogeneity in a panel for all attributes must be intensively practiced for a non-scaled line. Since so-called “outliers” can be eliminated by the PSV (see QHV methodology), the QHV evaluation with the median is as accurate as the official panel test. All the factors to be evaluated are well known to the international olive oil experts and tasters. Only the aroma designations may differ from tester to tester and from country to country, because not all aromas are common to every tester. Regardless, however, an individual aroma or aroma bouquet can be recognized by the tester in each country, as well as the evaluation of clarity and flavor. But even better, if the tasters stay longer in the panel, the continuous training and practice allow the summary of all mentioned criteria on one additional line (Figures 3 and 4) at the end of the official profile sheet. This means that the taster makes his evaluation in one operation first for the classification according to Reg. (EEC) 2568/91 in its current version (or the corresponding IOC standard) and then finally his decision for the value for the QHV (method DOP-2007-2).
The idea of this additional parameter harmony is to assign oils with the classification EVOO to additionally defined quality groups (Figure 6). This additional quality criterion is not regulated by law. However, the trade now has the possibility to select oils according to the requirements of the market in terms of price and quality.
Definition of QHV quality levels for the different grades of EVOO with the method DOP-2007-2.
The unofficial assessment of QHV in the panel test should not be mandatory, but it should be an important option for the trade. Basically, the quality of an olive oil does not remain constant, but deteriorates slightly over the course of 18 months due to decreasing fruitiness and freshness. This and the fact that in the mass market new batches have to be compiled again and again during the year due to the large quantities require constant sensory control also on the basis of specifications from the trade. These specifications must not be utopian, but must be based on realistic values depending on the season.
The QHV methodology also includes the following guidelines [13]:
The valid median must have a robust coefficient of variation (CVr) below 10%.
Single results that exceed from the median by 1.5 or more have to be eliminated by the PSV. In case of a panel with eight tasters, only at least six from eight tasters need to have a valid result for the median of the QHV.
Suggestion of including the control of the Z-Score for the QHV in connection with the results of the PT for every taster.
The PSV is as well able to moderate single results of the QHV only.
In case a valid median of a defect is reached, the harmony value is set to zero (0) by the PSV.
The repeatability
The application of this new criterion in sensory analysis since 2011 has led to a clearly recognizable improvement in the quality of olive oils on the German-speaking market as the figures from the IGO/DOP do prove. Every year, the DOP tests about 1000 samples according to this scheme, including harmony. Figure 7 illustrates that at the beginning in 2011, only 26% of the EVOO were rated >5.0–10 on the scale (from “higher standard” to “excellent”). By 2020, this figure had already risen to 75.6%. A measurable success for quality and thus for consumer protection. The trend from 2013 to 2020 in particular shows the remarkable way with a significant decrease in very poor qualities (QHV between 3.1 and 4.4) and also in the range of 4.5–5.0 (“lower standard”). The standard quality originally ranged from 4.5 to 5.4, but since more than 50% of all samples were in this segment, the standard quality was divided into lower (4.5–5.0) and upper standard (5.1–5.4). As a result, traders with their supporters focused only on the upper standard quality. The columns also show a remarkable increase in the range of 5.5–6.4 (QHV “good quality”) for the first wave of 2017, which seems remarkable as 2017 was a difficult year in terms of harvest in different producing countries.
QHV results 2011–.2021(%) in Germany (source: IGO/DOP), n = 7500, results 2021 preliminary).
The QHV value is still unofficial and not part of the regulation, but it is firmly established in practice in German-speaking countries and is slowly gaining more and more acceptance among other importing and supporting companies. In the first years, the introduction process of the QHV was somewhat tough. Since 2011, the method has been presented to the professional public in further workshops and congresses [14, 15, 16] and backed up with initial figures. In countries with strong trade groups such as Germany, Austria, Switzerland, and others, the trade began to take an interest in the QHV, as media such as TV and the press—partly justified—were constantly looking for points of attack to devalue the olive oil quality at supermarket chains and discounters. The Information Office Olive Oil [17] in Germany (IGO) has therefore organized seminars at almost all relevant food companies since 2005, in which the QHV was explained as an important additional parameter. In the first years, the trade was content with at least reaching the level of >4.5 (standard quality) on the QHV scale. After a few years, the next level followed with 5.0—5.4 (upper standard). This was certainly due to the fact that the national control medium Stiftung Warentest considered the QHV as a co-decisive criterion in their comparative tests for the quality of an olive oil. This has also led to interest in this type of assessment on the part of bottlers, traders, and producers. At the request of the trade, introductory seminars were also held in the producer countries by the IGO. This led to further quality improvements in the trade, as now the quality became measurable with the help of the QHV method, which has also been accredited by the official German inspection body (DAkkS) since 2015. Now the trade is able to demand specified sensory quality requirements (intensities of fruity, bitter, spicy plus QHV) from its suppliers. However, due to the annually fluctuating characteristics of olive oils and the natural decrease of the individual intensities, the requirements have to be redefined every year or adapted to the annual rhythm by neutral experts.
Of course, thought was given to including the QHV on the label. However, for various reasons, this was not done and the responsibility was left to the trade. On the one hand, the label for EVOO is already very extensive due to numerous legal requirements. Since the QHV would entail an additional need for explanation for the consumer and it is also only used in a few countries, this idea had to be abandoned for the time being.
But in addition the type of fruitiness—green, green/ripe, or ripe fruitiness—became also part of the EC/IOC regulation in the framework of the panel test. Our investigations showed that these differences also had an impact on the assessment of the QHV. The graphic (Figure 8) shows an example from Greek oils in 2018: EVOO with green flavor received QHV scores in the range of 5.6–6.4 (very good) due to aroma richness and more intense fruitiness. For oils with green and ripe taste, i.e., from fruits with advanced ripeness, most QHV scores were between 5.1 and 6.4 (upper standard to very good). Oils with a more mature taste from ripe harvested fruits mostly reached QHV values of 4.5–5.4 (standard), partly because the fruit intensity is milder and the aromas are sweeter. In the latter EVOO, the polyphenol values are already significantly lower, which, among other parameters, also affects the stability of the oil. Due to natural conditions—ripening is a continuous process—harvesting times have been moved forward somewhat in some countries to increase the proportion of green or green/ripe olives. This is also in order to gain more green aromas, a higher nutritional value, and as a consequence, a slightly higher QHV value.
Type of fruitiness and relevance for the QHV, grün = green; grün-reif = green-ripe; reif = ripe, source: 2018, n = 157 Greek samples, IGO [
The effect of the QHV also opens the consumer’s senses for special characteristics of blended and country-specific oils—and that also for more affordable oils in the so-called mass market. To this end, we have broken down certain parts of the DOP test results of the last 7 years country by country to show differences and improvements. *The reader may pay attention to the fact that the calibration of the intensity of fruitiness in the DOP panel has changed 2021 to a slightly higher level. This step was initiated and practiced by a modified method in the framework of an IOC workshop and started in year 2021, but the process for the DOP panel has not yet been finalized.
(9a) Fruitiness rating Spain, 2015–2021 (%), n = 65–265, (9b) QHV rating Spain, 2015–2021 (%), n = 65–265. Source: IGO/DOP.
(10a) Fruitiness rating Italy, −2015-2021 (%), n = 50–76, (10b) QHV rating Italy, 2015–2021, (%) n = 50–76. Source: IGO/DOP.
In contrast to the above named countries,
(11a) Fruitiness rating Greece, 2015–2021(%) n = 95–166, (11b) QHV rating Greece, 2015–2021 (%), n = 95–166. Source: IGO/DOP.
(12a) Fruitiness rating EU blend 2015–2021, (%), (12b) QHV rating EU blend 2015–2021 (%). Source: IGO/DOP.
Correspondingly, the value 4.5–5.0 (lower standard) dropped from 34.1–18%. EU blends are often the “price entry quality” for many nationally active traders.
The origin from the yearly up to 1000 DOP samples is roughly 20% Greek oil, 10% Italian, 30% from Spain, and 40% EU Blend. The figures for 2021 are not yet complete. In connection with all the above results, equally excellent EVOO were tested, some of which also won prizes in international competitions. These results have not been broken down by country, but they have a negligible impact on the above results, as they only account for 5–7% of the total number of samples per year. Values above 8.5–9, even up to 10, are extremely rare. But as already mentioned: “The higher the quality, the lower the quantity available in the trade”—therefore only a few oils can reach this segment.
Samples from other countries such as Portugal, Tunisia, Turkey, Croatia, Slovenia, and Palestine were also evaluated, but the number of samples per country was not sufficient for serious statistics.
The results for the individual production countries, as well as for all samples together, undeniably show the way to a quality improvement over a long period of time that was hardly thought possible. This is true not only in German-speaking countries, where during the previous years around 1000 panel tests are conducted annually, but also for production and distribution of some international brands. Last but not least, it was the trade that took up the idea in order to get olive oil out of the headlines of the negative press. After all, olive oil was once in the top group of food products that drew attention to themselves through fraud and adulteration. But the figures on which this study is based speak primarily for Germany, Austria, and Switzerland. In these countries, the control policy of the trade often still goes far beyond the requirements of the government or the European Commission. This also applies to the sensory analysis of olive oil taste, a decisive criterion for the consumer.
With the QHV, the trade received an additional quality parameter that closes the gap between the best classification (EVOO) and measurable quality grades for this classification. The trade—in the meantime also instructed in the QHV method—works out a profile for its various olive oils with expert advisors and passes it on to the producers. These—as well QHV trained—receive thus specifications for the production or blending. This helps the trade to the same extent with the so-called “borderline problem” between the two grades EVOO and VOO. With EVOO there are good and bad ones, with VOO there are always a median of defect with intensities up to 3.5. The QHV would certify a bad EVOO a very low rating and thus inform the buyer accordingly. However, the results also show that it is possible to achieve a certain good quality level with the QHV even with supermarket and discount chains—i.e., with very large quantities. Whether to achieve “upper standard” or “very good” is up to the retailer in each country to decide. But thanks to QHV, the desired level is quantifiable.
The evidence gathered since the QHV presentation in September 2019 to the IOC Expert Group on Sensory Items held in Madrid does not indicate that the QHV method will be adopted globally. However, it may be introduced on a country-by-country basis or applied by nongovernmental bodies at the request of operators. It was found that in some olive oil producing countries, there is a kind of creeping path for improving the field of processing from agriculture via harvesting, malaxation [2] to extraction.
The QHV method was developed with a focus on the transparent presentation of the different qualities of the “extra virgin” grade of this exceptional product olive oil. Since 2011, attempts have been made to show the possibilities of the QHV to the IOC as well [13, 19] in order to start joint international trials that would enable its possible use in other countries. While the Commission in Brussels accepts or nationally tolerates some member countries’ own initiatives—especially against the background of consumer protection with simultaneous proper production—the seemingly unassailable IOC seems to be pursuing its own policy under the protective shield of the UN. The national and economic benefits of olive oil are of undisputed importance in the producing countries. But it should also be transparent in the importing countries and compatible with the qualitative and legal requirements of consumers in their countries.
The QHV provides security in the assessment of EVOO qualities, it creates measurable transparency in the field of marginal oils, it limits the possibilities of fraud and helps in the detection of adulteration. With the QHV, there are fewer complaints and more satisfied customers.
QHV | Quantified Harmony Value |
EVOO | Extra Virgin Olive Oil |
VOO | Virgin Olive Oil |
LVOO | Lampante Virgin Olive Oil |
OO | Olive Oil (Refined Olive Oil Plus EVOO) |
PT | Panel Test |
IOC | International Olive Council |
DOP | German Olive Oil Panel |
PSV | Panel Supervisor/Panel Leader |
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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\n\n\n\nAll chapters will be published via IntechOpen's 'Online First' service meaning chapters will be published individually, immediately after review and before the entire book is ready for publication, allowing content to be shared, searched and cited straightaway, thereby generating early stage interest and momentum for your research
\n\nOnline First Chapters are considered published on the day they are posted and are citable from that date.
\n\nChapters will remain listed as Online First until the final versions of the books are published online. Following publication of the full monograph, Chapters will be redirected from the Online First version and will be available only through the final link of the official published page.
\n\nYou are invited to download, use, reproduce, make derivative works of, display, distribute and cite the Online First works. You can find "How to Cite and Reference" by following the link at the end of each online book chapter. Please be aware that it is possible that further editing and changes might be made before the final release of the book.
\n\nIf there are supplemental materials to the chapter, these will be published at the time the final book is published online.
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Alexandris",coverURL:"https://cdn.intechopen.com/books/images_new/3082.jpg",editedByType:"Edited by",editors:[{id:"150921",title:"Dr.",name:"Stavros",middleName:"G",surname:"Alexandris",slug:"stavros-alexandris",fullName:"Stavros Alexandris"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3491",title:"Current Perspectives in Contaminant Hydrology and Water Resources Sustainability",subtitle:null,isOpenForSubmission:!1,hash:"8fb9b880397a9a6e536cf504ca7dfe56",slug:"current-perspectives-in-contaminant-hydrology-and-water-resources-sustainability",bookSignature:"Paul M. Bradley",coverURL:"https://cdn.intechopen.com/books/images_new/3491.jpg",editedByType:"Edited by",editors:[{id:"105017",title:"Dr.",name:"Paul",middleName:"M.",surname:"Bradley",slug:"paul-bradley",fullName:"Paul Bradley"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"911",title:"Water Stress",subtitle:null,isOpenForSubmission:!1,hash:"639300ffd325d217a7b6ec2261ff26e0",slug:"water-stress",bookSignature:"Ismail Md. Mofizur Rahman and Hiroshi Hasegawa",coverURL:"https://cdn.intechopen.com/books/images_new/911.jpg",editedByType:"Edited by",editors:[{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:13,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"27305",doi:"10.5772/39363",title:"Water Stress in Plants: Causes, Effects and Responses",slug:"water-stress-in-plants-causes-effects-and-responses",totalDownloads:28410,totalCrossrefCites:66,totalDimensionsCites:164,abstract:null,book:{id:"911",slug:"water-stress",title:"Water Stress",fullTitle:"Water Stress"},signatures:"Seyed Y. S. Lisar, Rouhollah Motafakkerazad, Mosharraf M. Hossain and Ismail M. M. Rahman",authors:[{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman"}]},{id:"53211",doi:"10.5772/66416",title:"Biofloc Technology (BFT): A Tool for Water Quality Management in Aquaculture",slug:"biofloc-technology-bft-a-tool-for-water-quality-management-in-aquaculture",totalDownloads:16802,totalCrossrefCites:58,totalDimensionsCites:135,abstract:"Biofloc technology (BFT) is considered the new “blue revolution” in aquaculture. Such technique is based on in situ microorganism production which plays three major roles: (i) maintenance of water quality, by the uptake of nitrogen compounds generating in situ microbial protein; (ii) nutrition, increasing culture feasibility by reducing feed conversion ratio (FCR) and a decrease of feed costs; and (iii) competition with pathogens. The aggregates (bioflocs) are a rich protein-lipid natural source of food available in situ 24 hours per day due to a complex interaction between organic matter, physical substrate, and large range of microorganisms. This natural productivity plays an important role recycling nutrients and maintaining the water quality. The present chapter will discuss some insights of the role of microorganisms in BFT, main water quality parameters, the importance of the correct carbon-to-nitrogen ratio in the culture media, its calculations, and different types, as well as metagenomics of microorganisms and future perspectives.",book:{id:"5355",slug:"water-quality",title:"Water Quality",fullTitle:"Water Quality"},signatures:"Maurício Gustavo Coelho Emerenciano, Luis Rafael Martínez-\nCórdova, Marcel Martínez-Porchas and Anselmo Miranda-Baeza",authors:[{id:"146126",title:"Dr.",name:"Maurício Gustavo Coelho",middleName:null,surname:"Emerenciano",slug:"mauricio-gustavo-coelho-emerenciano",fullName:"Maurício Gustavo Coelho Emerenciano"},{id:"186970",title:"Prof.",name:"Marcel",middleName:null,surname:"Martínez-Porchas",slug:"marcel-martinez-porchas",fullName:"Marcel Martínez-Porchas"},{id:"186971",title:"Prof.",name:"Anselmo",middleName:null,surname:"Miranda-Baeza",slug:"anselmo-miranda-baeza",fullName:"Anselmo Miranda-Baeza"},{id:"195101",title:"Dr.",name:"Luis Rafael",middleName:null,surname:"Martínez-Córdoba",slug:"luis-rafael-martinez-cordoba",fullName:"Luis Rafael Martínez-Córdoba"}]},{id:"53194",doi:"10.5772/66561",title:"Impact of Wastewater on Surface Water Quality in Developing Countries: A Case Study of South Africa",slug:"impact-of-wastewater-on-surface-water-quality-in-developing-countries-a-case-study-of-south-africa",totalDownloads:7626,totalCrossrefCites:63,totalDimensionsCites:120,abstract:"Wastewater effluents are major contributors to a variety of water pollution problems. Most cities of developing countries generate on the average 30–70 mm3 of wastewater per person per year. Owing to lack of or improper wastewater treatment facilities, wastewater and its effluents are often discharged into surface water sources, which are receptacles for domestic and industrial wastes, resulting to pollution. The poor quality of wastewater effluents is responsible for the degradation of the receiving surface water body. Wastewater effluent should be treated efficiently to avert adverse health risk of the user of surface water resources and the aquatic ecosystem. The release of raw and improperly treated wastewater onto water courses has both short‐ and long‐term effects on the environment and human health. Hence, there should be proper enforcement of water and environmental laws to protect the health of inhabitants of both rural and urban communities. This study reports major factors responsible for the failing state of wastewater treatment facilities in developing countries, which includes poor operational state of wastewater infrastructure, design weaknesses, lack of expertise, corruption, insufficient funds allocated for wastewater treatment, overloaded capacities of existing facilities, and inefficient monitoring for compliance, among others.",book:{id:"5355",slug:"water-quality",title:"Water Quality",fullTitle:"Water Quality"},signatures:"Joshua N. Edokpayi, John O. Odiyo and Olatunde S. Durowoju",authors:[{id:"187867",title:"Dr.",name:"Joshua",middleName:null,surname:"Edokpayi",slug:"joshua-edokpayi",fullName:"Joshua Edokpayi"},{id:"189690",title:"Prof.",name:"John",middleName:null,surname:"Odiyo",slug:"john-odiyo",fullName:"John Odiyo"},{id:"194678",title:"Dr.",name:"Olatunde",middleName:"Samod",surname:"Durowoju",slug:"olatunde-durowoju",fullName:"Olatunde Durowoju"}]},{id:"52639",doi:"10.5772/65744",title:"Metals Toxic Effects in Aquatic Ecosystems: Modulators of Water Quality",slug:"metals-toxic-effects-in-aquatic-ecosystems-modulators-of-water-quality",totalDownloads:4232,totalCrossrefCites:21,totalDimensionsCites:47,abstract:"The topic of this work was based on the assessment of aquatic systems quality related to the persistent metal pollution. The use of aquatic organisms as bioindicators of metal pollution allowed the obtaining of valuable information about the acute and chronic toxicity on common Romanian aquatic species and the estimation of the environment quality. Laboratory toxicity results showed that Cd, As, Cu, Zn, Pb, Ni, Zr, and Ti have toxic to very toxic effects on Cyprinus carpio, and this observation could raise concerns because of its importance as a fishery resource. The benthic invertebrates’ analysis showed that bioaccumulation level depends on species, type of metals, and sampling sites. The metal analysis from the shells of three mollusk species showed that the metals involved in the metabolic processes (Fe, Mn, Zn, Cu, and Mg) were more accumulated than the toxic ones (Pb, Cd). The bioaccumulation factors of metals in benthic invertebrates were subunitary, which indicated a slow bioaccumulation process in the studied aquatic ecosystems. The preliminary aquatic risk assessment of Ni, Cd, Cr, Cu, Pb, As, and Zn on C. carpio revealed insignificant to moderate risk considering the measured environmental concentrations, acute and long-term effects and environmental compartment.",book:{id:"5355",slug:"water-quality",title:"Water Quality",fullTitle:"Water Quality"},signatures:"Stefania Gheorghe, Catalina Stoica, Gabriela Geanina Vasile, Mihai\nNita-Lazar, Elena Stanescu and Irina Eugenia Lucaciu",authors:[{id:"186964",title:"Dr.",name:"Stefania",middleName:null,surname:"Gheorghe",slug:"stefania-gheorghe",fullName:"Stefania Gheorghe"},{id:"194072",title:"Dr.",name:"Catalina",middleName:null,surname:"Stoica",slug:"catalina-stoica",fullName:"Catalina Stoica"}]},{id:"42035",doi:"10.5772/55354",title:"Arsenic in Groundwater: A Summary of Sources and the Biogeochemical and Hydrogeologic Factors Affecting Arsenic Occurrence and Mobility",slug:"arsenic-in-groundwater-a-summary-of-sources-and-the-biogeochemical-and-hydrogeologic-factors-affecti",totalDownloads:6141,totalCrossrefCites:6,totalDimensionsCites:45,abstract:null,book:{id:"3491",slug:"current-perspectives-in-contaminant-hydrology-and-water-resources-sustainability",title:"Current Perspectives in Contaminant Hydrology and Water Resources Sustainability",fullTitle:"Current Perspectives in Contaminant Hydrology and Water Resources Sustainability"},signatures:"Julia L. Barringer and Pamela A. Reilly",authors:[{id:"163098",title:"Dr.",name:"Julia",middleName:null,surname:"Barringer",slug:"julia-barringer",fullName:"Julia Barringer"},{id:"167449",title:"M.Sc.",name:"Pamela",middleName:"A.",surname:"Reilly",slug:"pamela-reilly",fullName:"Pamela Reilly"}]}],mostDownloadedChaptersLast30Days:[{id:"58138",title:"Water Pollution: Effects, Prevention, and Climatic Impact",slug:"water-pollution-effects-prevention-and-climatic-impact",totalDownloads:21387,totalCrossrefCites:16,totalDimensionsCites:32,abstract:"The stress on our water environment as a result of increased industrialization, which aids urbanization, is becoming very high thus reducing the availability of clean water. Polluted water is of great concern to the aquatic organism, plants, humans, and climate and indeed alters the ecosystem. The preservation of our water environment, which is embedded in sustainable development, must be well driven by all sectors. While effective wastewater treatment has the tendency of salvaging the water environment, integration of environmental policies into the actor firms core objectives coupled with continuous periodical enlightenment on the present and future consequences of environmental/water pollution will greatly assist in conserving the water environment.",book:{id:"6157",slug:"water-challenges-of-an-urbanizing-world",title:"Water Challenges of an Urbanizing World",fullTitle:"Water Challenges of an Urbanizing World"},signatures:"Inyinbor Adejumoke A., Adebesin Babatunde O., Oluyori Abimbola\nP., Adelani-Akande Tabitha A., Dada Adewumi O. and Oreofe Toyin\nA.",authors:[{id:"101570",title:"MSc.",name:"Babatunde Olufemi",middleName:null,surname:"Adebesin",slug:"babatunde-olufemi-adebesin",fullName:"Babatunde Olufemi Adebesin"},{id:"187738",title:"Dr.",name:"Adejumoke",middleName:"Abosede",surname:"Inyinbor",slug:"adejumoke-inyinbor",fullName:"Adejumoke Inyinbor"},{id:"188818",title:"Dr.",name:"Abimbola",middleName:null,surname:"Oluyori",slug:"abimbola-oluyori",fullName:"Abimbola Oluyori"},{id:"188819",title:"Mrs.",name:"Tabitha",middleName:null,surname:"Adelani-Akande",slug:"tabitha-adelani-akande",fullName:"Tabitha Adelani-Akande"},{id:"208501",title:"Dr.",name:"Adewumi",middleName:null,surname:"Dada",slug:"adewumi-dada",fullName:"Adewumi Dada"},{id:"208502",title:"Ms.",name:"Toyin",middleName:null,surname:"Oreofe",slug:"toyin-oreofe",fullName:"Toyin Oreofe"}]},{id:"66437",title:"Detection of Underground Water by Using GPR",slug:"detection-of-underground-water-by-using-gpr",totalDownloads:2945,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Water is the human vital requirement for life; in these days, decreasing of the fresh water increases the importance of the aquifer water. However, Upper Egypt is higher than north Egypt, so the water map continually changes daily, and the aquifer water is deeper than 10 m. The ground penetrating radar (GPR) system is used for underground water detection. GPR is a promising technology to detect and identify aquifer water or nonmetallic mines. One of the most serious components for the performance of GPR is the antenna system. The technology of the remote sensing and radar is rapidly developing, and it has led to the ultra-wideband electronic systems. All of these factors, such as miniaturized, low cost, possible compromise solution between depth and resolution, scanning in real time, easy to interpret, and decreased the false alarm, are important in designing the ground penetrating system. The electrical properties of the sand and fresh water layers are investigated using laboratory measurement and EM simulation. Different types of antenna may be used in GPR to operate over a frequency range for different penetration depth. Frequency-modulated continuous wave is also used for GPR and for through-the-wall applications. However, most of these kinds of antennas are limited by their large volume for certain applications. Therefore, a compact Vivaldi antenna with EBG and a compact planar printed quasi-Yagi antenna with meandered ground plane are designed to fulfill all above requirement.",book:{id:"6836",slug:"groundwater-resource-characterisation-and-management-aspects",title:"Groundwater",fullTitle:"Groundwater - Resource Characterisation and Management Aspects"},signatures:"Dalia N. Elsheakh and Esmat A. Abdallah",authors:[{id:"111813",title:"Dr.",name:"Dalia",middleName:null,surname:"Elsheakh",slug:"dalia-elsheakh",fullName:"Dalia Elsheakh"},{id:"111867",title:"Prof.",name:"Esmat",middleName:null,surname:"Abdallah",slug:"esmat-abdallah",fullName:"Esmat Abdallah"}]},{id:"57345",title:"Safe Drinking Water: Concepts, Benefits, Principles and Standards",slug:"safe-drinking-water-concepts-benefits-principles-and-standards",totalDownloads:6046,totalCrossrefCites:11,totalDimensionsCites:23,abstract:"Water is connected to every forms of life on earth. As a criteria, an adequate, reliable, clean, accessible, acceptable and safe drinking water supply has to be available for various users. The United Nation (UN) and other countries declared access to safe drinking water as a fundamental human right, and an essential step towards improving living standards. Access to water was one of the main goal of Millinium Development Goals (UN-MDGs) and it is also one of the main goal of the Sustainable Development Goals (SDGs). The UN-SDG goal 6 states that “Water sustains life, but safe clean drinking water defines civilization”. Despite these facts, there are inequalities in access to safe drinking water in the world. In some countries, sufficient freshwater is not available (physical scarcity); while in other countries, abundant freshwater is available, but it is expensive to use (economic scarcity). The other challenge is the increasing population of the world at an alarming rate, while the available freshwater resources almost remains constant. This chapter presents aspects of safe drinking water - background information, definition of water safety and access, benefits, principles and regulations, factors challenging the sustainable water supply and water quality standards and parameters.",book:{id:"6157",slug:"water-challenges-of-an-urbanizing-world",title:"Water Challenges of an Urbanizing World",fullTitle:"Water Challenges of an Urbanizing World"},signatures:"Megersa Olumana Dinka",authors:[{id:"206964",title:"Dr.",name:"Megersa Olumana",middleName:null,surname:"Dinka",slug:"megersa-olumana-dinka",fullName:"Megersa Olumana Dinka"}]},{id:"53211",title:"Biofloc Technology (BFT): A Tool for Water Quality Management in Aquaculture",slug:"biofloc-technology-bft-a-tool-for-water-quality-management-in-aquaculture",totalDownloads:16802,totalCrossrefCites:58,totalDimensionsCites:135,abstract:"Biofloc technology (BFT) is considered the new “blue revolution” in aquaculture. Such technique is based on in situ microorganism production which plays three major roles: (i) maintenance of water quality, by the uptake of nitrogen compounds generating in situ microbial protein; (ii) nutrition, increasing culture feasibility by reducing feed conversion ratio (FCR) and a decrease of feed costs; and (iii) competition with pathogens. The aggregates (bioflocs) are a rich protein-lipid natural source of food available in situ 24 hours per day due to a complex interaction between organic matter, physical substrate, and large range of microorganisms. This natural productivity plays an important role recycling nutrients and maintaining the water quality. The present chapter will discuss some insights of the role of microorganisms in BFT, main water quality parameters, the importance of the correct carbon-to-nitrogen ratio in the culture media, its calculations, and different types, as well as metagenomics of microorganisms and future perspectives.",book:{id:"5355",slug:"water-quality",title:"Water Quality",fullTitle:"Water Quality"},signatures:"Maurício Gustavo Coelho Emerenciano, Luis Rafael Martínez-\nCórdova, Marcel Martínez-Porchas and Anselmo Miranda-Baeza",authors:[{id:"146126",title:"Dr.",name:"Maurício Gustavo Coelho",middleName:null,surname:"Emerenciano",slug:"mauricio-gustavo-coelho-emerenciano",fullName:"Maurício Gustavo Coelho Emerenciano"},{id:"186970",title:"Prof.",name:"Marcel",middleName:null,surname:"Martínez-Porchas",slug:"marcel-martinez-porchas",fullName:"Marcel Martínez-Porchas"},{id:"186971",title:"Prof.",name:"Anselmo",middleName:null,surname:"Miranda-Baeza",slug:"anselmo-miranda-baeza",fullName:"Anselmo Miranda-Baeza"},{id:"195101",title:"Dr.",name:"Luis Rafael",middleName:null,surname:"Martínez-Córdoba",slug:"luis-rafael-martinez-cordoba",fullName:"Luis Rafael Martínez-Córdoba"}]},{id:"52639",title:"Metals Toxic Effects in Aquatic Ecosystems: Modulators of Water Quality",slug:"metals-toxic-effects-in-aquatic-ecosystems-modulators-of-water-quality",totalDownloads:4232,totalCrossrefCites:21,totalDimensionsCites:47,abstract:"The topic of this work was based on the assessment of aquatic systems quality related to the persistent metal pollution. The use of aquatic organisms as bioindicators of metal pollution allowed the obtaining of valuable information about the acute and chronic toxicity on common Romanian aquatic species and the estimation of the environment quality. Laboratory toxicity results showed that Cd, As, Cu, Zn, Pb, Ni, Zr, and Ti have toxic to very toxic effects on Cyprinus carpio, and this observation could raise concerns because of its importance as a fishery resource. The benthic invertebrates’ analysis showed that bioaccumulation level depends on species, type of metals, and sampling sites. The metal analysis from the shells of three mollusk species showed that the metals involved in the metabolic processes (Fe, Mn, Zn, Cu, and Mg) were more accumulated than the toxic ones (Pb, Cd). The bioaccumulation factors of metals in benthic invertebrates were subunitary, which indicated a slow bioaccumulation process in the studied aquatic ecosystems. The preliminary aquatic risk assessment of Ni, Cd, Cr, Cu, Pb, As, and Zn on C. carpio revealed insignificant to moderate risk considering the measured environmental concentrations, acute and long-term effects and environmental compartment.",book:{id:"5355",slug:"water-quality",title:"Water Quality",fullTitle:"Water Quality"},signatures:"Stefania Gheorghe, Catalina Stoica, Gabriela Geanina Vasile, Mihai\nNita-Lazar, Elena Stanescu and Irina Eugenia Lucaciu",authors:[{id:"186964",title:"Dr.",name:"Stefania",middleName:null,surname:"Gheorghe",slug:"stefania-gheorghe",fullName:"Stefania Gheorghe"},{id:"194072",title:"Dr.",name:"Catalina",middleName:null,surname:"Stoica",slug:"catalina-stoica",fullName:"Catalina Stoica"}]}],onlineFirstChaptersFilter:{topicId:"837",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:48,paginationItems:[{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. 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After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"onlineFirst.detail",path:"/online-first/81058",hash:"",query:{},params:{id:"81058"},fullPath:"/online-first/81058",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()