Economic model.
Six Sigma methods and techniques are applied in business & IT projects for product (Goods and Services) & process design (Define, Measure, Analyze, Design and Verify or DMADV) and improvements (Define, Measure, Analyze, Improve and Control or DMAIC). Six sigma methodologies have been applied within the IT Service Management disciplines primarily for Service and Process Improvement and Optimization.
Six Sigma methods and techniques have a relatively rich history with the manufacturing industry and tangible products vis-à-vis intangible and perishable services. As the services industries look forward to the advent of productization of services or service products, there is an attempt to minimize variations in service quality via service design and service improvement projects. The focus of these projects range from service definition to service systems to service automation (i.e. making service less labour intensive). As such, six sigma methods and techniques have a major role to play in both design and improvement of services and service management processes.
Even though Six Sigma concepts & techniques can be applied for most if not all IT Service management processes (see ITIL v3 for taxonomy of Service Management processes mapped to the Service Life Cycle), they will primarily relate to Service Quality Management processes such as:
Service Availability Management
Service Capacity Management
Service Performance Management
Service Continuity Management
Service Security Management
(Service) Event Management
(Service) Incident Management and
(Service) Problem Management
This paper discusses six sigma methods (both DMAIDV and DMAIC) and techniques as they apply to the fives stages of Process Maturity (or Service Management Maturity)
Ad hoc
Defined
Measured
Matured &
Optimized
Note: Some of the techniques discussed here are generally used within the Six Sigma and Quality Control and Management context and projects, but are also used in several non six sigma projects and context.
Note: Design for Six Sigma (DFSS) has not only been applied to Service Management processes but also for sub-processes such as Root Cause Analysis (RCA) as a sub-process within problem management or Incident Reporting (IR) as a sub-process within incident management.
IT Service Management Process Improvement relates to IT Service Management Maturity and the Continuous Process Improvement or CPI program. Service Quality is a function of (or depends on) People, Processes, Information and Technology and the maturity level of Service Quality Management as an IT process domain. Service Quality Management processes as IT processes play a critical role in understanding and achieving service quality objectives and targets.
Service Management as a practice has five maturity levels and each service management domain or IT process can be at different levels of maturity at a given time (see figure 1 below for the five different maturity levels and the corresponding process capabilities / features). Process maturity (and higher ratings of process maturity level) is attained via incremental process improvement projects. It is important to note that processes can only be improved from one maturity level to another sequentially. It is extremely difficult to skip maturity levels.
IT Service Management (ITSM) Process Maturity Levels
Six Sigma DMADV – Define (Process), Measure, Analyze, Design and Verify methodology is relevant for moving from level 1 to level 2 i.e. essentially developing an enterprise wide definition of an IT process and gathering requirements as part of the process design work.
Six Sigma DMAIC – Define (Process Improvement Problem), Measure, Analyze, Improve and Control as a methodology is relevant for growing the process from maturity level 2 to maturity level 3, 4 and 5.
See figure 2 below.
Six Sigma and IT Service Management (ITSM) Process Maturity Levels
Ad Hoc (Level 1 )
A process is at maturity level 1, when the enterprise does NOT have an enterprise wide consistent view of the process i.e. the process is NOT defined via documentation and published to spread process awareness within the extended enterprise. It is likely that certain process activities are defined and implemented in certain silos in the enterprise such as a business unit or a domain team (e.g. an enterprise network team).
Application of six sigma example: several lean six sigma concepts such as reducing or eliminating process waste can be applied during this stage of process maturity.
Defined and Aware (Level 2)
Level 2 maturity implies the process has been well defined; the process definition documents have been vetted among the process community and approved by key process stakeholders as well as published enterprise wide. This implies that the enterprise has a consistent view of the process and the different organizations are aware of the process, current process capabilities (activities, interfaces, tools, organization, among others). Process interfaces are also defined. There can be several qualitative process improvement projects (type 1 process improvement projects – see section below for a discussion on Type 1 and Type 2 projects) at this level of maturity as the process metrics (critical success factors, key goal indicators, key performance indicators, among others) are understood and documented. At this stage of process maturity, the process management team should be focused on managing the process with Management by Objective (MBO) principle.
Application of six sigma example: development of smart process metrics that align with the process principles, policies and guidelines. A process principle can map to multiple process policies and a process policy can map to multiple process guidelines (detailed guidelines) and rules. SMART metrics can directly map to guidelines. The principles to policies to guidelines (rules) heirarchy can provide guidance to automate the process and certain process activities.
Fishbone or Ishikawa diagrams can be used help define process and process scope. As an example: Faulty components impacting service availability is a service availability management process issue while a denial of service attack impacting service availability is a security management process issue.
DMADV method directly related to process maturity level 2.
Capable and Measured (Level 3)
Level 3 maturity implies that the qualitative process improvement projects initiated and completed at Level 2 have improved the process capabilities. The process management team has the capability to implement all relevant process activities, process interfaces and process related projects. More importantly, the process management is now focused on managing the process with Management by Metrics (MbM) principles. This implies that there is a robust and reliable measurement system in place to collect data on the SMART (Specific, Measurable, Attainable, Relevant and Time bound) process metrics. At this stage, the process management can initiate type 2 process improvement projects for those process metrics which already have an appropriate measurement system. The six sigma DMAIC method directly relates to process maturity levels 3, 4 and 5.
Application of six sigma example: development of a measurement system to gather data on specific SMART process metrics that align with the process principles, policies and guidelines.
Improved and Mature (Level 4)
At this level of maturity, the process management team is actively engaged in analyzing the process data and managing the process based on the results of the analysis. The process should be performing relatively well on most relevant process Key Performance Indicators (KPIs) based on the results of the improvement projects initiated at Level 2 and Level 3. The process and process capabilities are competitive as several of them have been technology enabled. Process is significantly technology enabled and as such is adaptable to changing business needs and requirements. Process Interfaces are not only defined, but also implemented and relatively mature. Process interfaces with other Business and IT Processes and Services are implemented, mature and efficient. Most process improvement projects are type 2 projects.
Note: Very few IT organizations reach maturity level 4 and 5.
Application of six sigma example: six sigma process improvement projects focused on a specific quantifiable process improvement problem that improves the process along one or more key process metric (SMART metric). Optimized and Controlled (Level 5)
Very few organizations in the world have reached this level of maturity for process management. At this level of maturity, process management is focused on process efficiency, optimization and control as well as the strategic direction of the customer (business), and improving alignment with business, optimization of the process, process activities and process interfaces via a set of Type 2 process improvement projects. The process management team has also established a process control system to manage process deviations (outliers, drift, among others) i.e. a process exception handling system and sustain the process performance at the improved level.
Application of six sigma example: six sigma process improvement project focused on the development of one or more control systems focused on specific Process related KPIs. ITSM Process specific control systems are being developed by leading IT companies, as a case in point, an intelligent scaling engine or ISE (patented by author) can use real time service and resource data to make analytics based decisions to scale up or down specific services, service components and infrastructure resources that enable the service. ISE is specifically applicable to the performance and capacity management as an IT process.
These projects occur when the process has reached level 3 or higher levels of maturity (i.e. Process measurement systems are in place with process metrics and data for those metrics) and the improvement projects are focused on improving the process performance with regard to specific process metric or process related metrics (SMART objectives – Specific, Measurable, Attainable, Relevant and Time-Bound Objectives). Six Sigma as a process improvement method which leverages the define (define a process improvement problem / opportunity), measure, analyze, improve and control or DMAIC method, is very relevant for these types of process improvement projects.
The process and process related metrics can be metrics associated with the process inputs, actual processing (process activities), process outputs as well as process outcomes. In general, it is a good practice to focus Type 1 process improvement projects on metrics associated with the process outcomes (which are, generally, of more interest to business & process stakeholders). The process could focus on improving a measure of central tendency (such as mean – example mean time to recover/restore service) or a measure of variation (such as standard deviation – variation associated with the time to recover/restore service by service incident).
An example would be a six sigma project to improve average and variation (standard deviation) associated with the time to restore service via service recovery plans (which focus on fast recovery and restore technologies and updated service and component recovery plans and procedures for a set of services). The average time to restore service after a service incident can be measured before and after the project was implemented to study the impact of the six sigma project.
These projects can occur at any level of process maturity and do NOT have quantitative process or process related metrics associated with them.
An example would be a documentation project to define the process conceptually and logically and bring about a consistent enterprise wide view of the process and process objectives, scope, activities, among others. This would typically be done when a process is at level 1 in a process maturity scale.
Another example would be designing and building measurement systems to collect data around process metrics. This would typically be done when a process is at level 3 in a process maturity scale and aims to achieve the next level of process maturity.
In a purely technical sense, type 1 process improvement projects are the true process improvement projects and relate to the technical definition of improvement (shown below).
Improvements are Outcomes that when compared to the ‘before’ state, show a measurable increase in a desirable metric or decrease in an undesirable metric
Some of the key characteristics of six sigma methods and tools that are relevant for Business and IT service management and service quality management are discussed below:
Customer Centered (Customer or End User Centricity)
Several six sigma concepts such as Voice of the Customer (VOC) and Critical Customer Requirements are relevant for the service quality or non functional requirements gathering and documentation process.
Process Focused
Extraordinary Process for Ordinary People
ITIL v3 and other IT operating models focus on multiple IT process domains. Service Quality Management itself is a set of processes in the service design phase of the service life cycle but has implications for the entire service life cycle. Six sigma takes a process approach to quality management & quality improvement (both product/service as well as process quality) and as such can be applied to
IT enabled Business Service Quality & IT Service Quality as well as
Quality Management as a process domain in Business Service Management and IT Service Management models.
Data Driven
Six sigma projects are data driven and depend on data and analysis of data for quality improvements. Service and process quality data is generated from multiple tools, including monitoring and management tools. IT organizations can and do maintain historical and current service and process quality data which are relevant for applying six sigma projects.
Follows a structured method & roadmap
DMAIC and DMAIDV are two methods applied for
Product (such as Hardware) and Service (such as messaging) design
Product / Service Improvements
Process Design (such as Service Incident Management) and
Process Improvements
Oriented toward Business results.
The primary objectives of Business Service Management (BSM) and IT Service Management (ITSM) focus on business outcomes and aligning business and IT, as such six sigma’s focus on business results maps to service management focus on business objectives.
In general the tools and techniques discussed here can be used for both process design and process improvement projects, however, few of them are more applicable for process definition and design while others are more applicable for process improvement and control projects.
Quality Function Deployment and the House of Quality are critical tools for identifying, gathering, prioritizing, implementing and tracing service quality or non-functional requirements (both IT service and IT process requirements). IT processes are generally automated and implemented with a set of ITSM tools and technologies – hence QFD and HOQ can be applied to these tooling requirements also.
In my Non Functional (or Service Quality) Requirements (NFR) framework paper (The Open Group White Papers 2009 – see references), I discuss how service quality objectives such as service availability, or service continuity or service usability objectives can be documented as funded requirements (business, customer and end user centric), which then can be translated to design specifications and configuration parameters for service run time environment. I have also argued that we can develop enterprise specific and enterprise level service quality models, that document these objectives, requirements, specifications, parameters and metrics (measurable) to allow for reuse (do not have to reinvent the wheel with every service and every business unit) and traceability of service quality requirements.
Defects Per Million Opportunities (DPMO) is a relatively simple concept and is applied using a simple approach for the manufacturing industry engaged in producing tangible products. However, DPMO can be applied in the service industries engaged in producing intangible, inseparable (production & consumption), perishable and more variable services using a different approach.
Specifically for the IT services and IT enabled business services, we can take two simultaneous approaches toward DPMO, i.e. a) DPMO associated with the service systems or systems that enable the service and b) DPMO associated with the customer experience or parts of the customer experience. Here we elaborate DPMO associated with the customer experience.
DPMO can be applied to each instance of customer interaction (example: Browsing an ecommerce site dedicated for the travel industry – hotels, rental cars, flights among others) i.e. treating each interaction as an opportunity.
DPMO can be applied to each instance of customer transaction (example: request and purchase of an online e-ticket) i.e. treating each customer transaction (or request for a transaction) as an opportunity.
DPMO can be applied to each instance of customer consumption (service provider production) – (example: The acts of checking in & choosing seat, boarding, taking an airline seat, experiencing air travel and off-boarding an airplane) i.e. treating each act of consumption as an opportunity.
DPMO can be applied to each instance of the customer experience (example: all of the three above, plus post sales service etc) i.e. treating the individual customer experience as an opportunity.
There fore, TCI, TCT, TCC and TCE (Total Customer Interaction, Transactions, Consumption and Experience can all be related to total opportunities (TO) and are relevant for determining defects per million opportunities.
The CRM, CIM and CEM (Customer Relationship Management, Customer Interaction Management and Customer Experience Management) software suites as well as Interactive Intelligence (Customer Interactive Intelligence) software and tools help service providers collect data to support objectives and metrics around defects per million opportunities (DPMO). In other words, these tools provide data for these measurements related to service DPMOs. This is true for IT enabled business services and IT services as well as IT enabled business processes and IT processes.
CTQ tree maps Customer Key Goal Indicators or Broad Customer / End User related Objectives to more specific customer related performance indicators or KPIs using such approaches as VOC or Voice of the Customer. When CTQ is applied in the context of IT enabled Business Services we get vital business functions (within a Business Service), which is an ITSM term. Therefore CTQ provides a means to arrive at VBFs.
Note: Key Goal Indicators (KGIs) and Key Performance Indicators (KPIs) are commonly used by CIO Offices and IT management and are also part of such IT frameworks as COBIT (Control Objectives for Information and related Technologies) and ITIL (IT Information Library). However, CTQs focus on broad customer objectives (KGI) and translating the same to more specific customer requirements (and metrics or KPIs associated with them).
Process KGI or Process Objectives are critical for Management by Objectives or MBO particularly at process maturity levels of 1 and 2. As the process measurement system is designed and implemented at the maturity level 3, MBM or Management by Metrics can be initiated to reach maturity level 4 and above. SMART (Specific, Measurable, Achievable, Relevant and Time Bound) Process Metrics and Process Analytics play a key role for MBM.
Both statistical and non-statistical analytical techniques propagated via the six sigma methods, particularly during the analyze phase of six sigma project have great relevance for service management process analytics. As an example: Event Tree Analysis, Fault Tree Analysis and Decision Tree Analysis, a set of related non-statistical analytical techniques (used in six sigma projects) have direct relevance for event, incident and problem management (three operational processes in service management) and indirect relevance for availability, continuity, performance & capacity, and security management (four design processes in service management). Most, if not all, analytical techniques covered by the six sigma methods are either directly relevant or indirectly relevant for one or more of service management processes.
Fishbone diagrams can be useful to identify and analyze potential causes for Service Quality issues. In this case we are using fishbone diagrams to better understand service availability issues. Fishbone analysis and diagrams can be useful tools to identify and analyze potential causes for Service Unavailability. Overall service availability and service unavailability are a function of multiple capabilities (see Fishbone One):
Technology Capabilities (see Fishbone Two)
Process Capabilities (see Fishbone Three)
Organizational Capabilities and
Information Capabilities
The fishbone diagrams are generic diagrams and can be used to for multiple purposes including conceptualizing service availability models. The diagrams below depict the Y is Fn of x (x1, x2, x3 ….) model. You can further decompose these models by making each of the x (or independent variable) a Y or dependent variable. These models can and need to be customized for each service. The x or independent variables impact overall service availability can also change with time. Fishbone diagrams can also be used as input for problem management.
Fishbone Diagrams for Understanding Service Availability:
Fishbone One for Overall Service Availability
Fishbone Two for Technology Factors
Fishbone Three for Process Factors
We have only discussed a few key examples of Six Sigma tools and techniques and their application to business and IT service management. Therefore, this is not an exhaustive list of relevant six sigma tools applicable for service management.
At its most fundamental, health risk (either clinical or financial) is a combination of two factors:
The chronic disease management (DM) programs of the early 2000s were implemented by payers and aimed to identify high risk or high need patients, particularly those that were not compliant with their treatments or who had gaps in care. Patient management was usually performed externally, often by telephone, by nurses employed by large disease management organizations. Although attempts were made to involve the patient’s providers, providers were not party to the payer contract. This model reached its peak with a number of Medicare Coordinated Care and Support demonstration programs between 2005 and 2008 [1, 2]. Because of the growth and importance of chronic disease management programs, the Centers for Medicare and Medicaid Services (CMS) of the US Dept. of Health and Human Services (HHS) established a major demonstration project, the Medicare Coordinated Care Project to evaluate 15 different models of care coordination [2, 3]. Although the demonstration program showed some improvement in the quality of care delivered to patients, the lack of demonstrated savings led to a decline in the type of vendor-based disease management programs popular up to that time, and an interest in programs that involved contracting directly with providers to take risk for patient outcomes.
By the end of the first decade of the 21st Century two things began to become clear: first, that these programs were not containing medical trend2 and second that the solution to rising costs had to include providers. As a result, CMS’s attention shifted to alternative payment models incorporating providers directly and focusing on a combination of cost, quality and patient satisfaction, an objective expressed by Berwick and others [4] as the “Triple Aim” in a heavily cited article. This shift was a reaction to the quality of care delivered within the US Healthcare system. A 2003 study [5] found that adults in the United States receive the generally accepted standard of preventive, acute, and chronic care only about 55% of the time. Quality of care “varied substantially according to the particular medical condition, ranging from 78.7 percent of recommended care to 10.5 percent of recommended care for alcohol dependence.” Pay for quality was intended increase the frequency of these measures by rewarding physicians for their achievement of evidence-based quality measures (such as screenings, tests for patient populations or adherence to prescriptions). The theory was that closing gaps in care and identifying health issues earlier would lead to reduced utilization of more expensive healthcare services later. The achievement of reduced cost of care in exchange for incentive payments made this a value-based initiative.
Following the failure of the disease management model to demonstrate financial success, Congress has passed a number of laws promoting different value-based initiatives, in addition to initiatives introduced by the Center for Innovation at CMS:
Medicare Improvements for Patients and Providers Act (MIPPA) 2008;
Affordable Care Act (ACA) 2010;
Bundled Payments for Care Improvement (BPCI and its successors) 2011;
Protecting Access to Medicare Act (PAMA) 2014;
The Medicare Access and CHIP Reauthorization Act (MACRA) 2015;
Medicare’s direct contracting model: Global and Professional Direct Contracting Model (GPDC) 2020.
In addition, CMS has introduced a number of alternative payment models (APMs). In these models, providers agree to accept a portion of their reimbursement, often in the form of a share of savings, based on achievement of certain goals, including improved quality, reduced utilization and reduced cost. APMs include Accountable Care Organizations (ACOs) as well as models aimed at specific conditions or provider organizations: Bundled Payments for Care Improvement (BPCI), Comprehensive Care for Joint Replacement, Comprehensive Primary Care, Comprehensive End-stage Renal Disease model, Kidney Care Choices model, and the Oncology Care Model (OCM). CMS’s stated objective is to move the entire health care market toward paying providers based on the quality, rather than the quantity of care they give patients.3
The Health Care Payment Learning and Action Network (HCP-LAN) is a group of public and private health care leaders launched by the U.S. Department of Health and Human Services (through CMS) in March 2015. HCP-LAN aligns public and private sector stakeholders in shifting away from the current fee-for-service, volume-based payment system to one that pays for high-quality care and improved health. HCP-LAN has published estimates of value-based contract penetration in different payer segments. Figure 1 illustrates a study published in 2019 predicting that as much as 100% of care will be delivered via a value-based contract by 2025.
Estimates of value-based contract growth in different payer segments.
The HCP-LAN 2020 survey of payers indicated that 40.9% of U.S. health care payments, representing approximately 238.8 million Americans and 80.2% of the covered population, flowed through HCP-LAN Categories 3&4 models (shared-risk and population-based payments).
As noted by Werner et al. in a 2021 study [6] “the complexity of the current suite of alternative payment models” and the variety and lack of standardization of different models make value-based contracting challenging. Figure 2 illustrates the development and growth of alternative payment models over time. The following discussion of contract types covers a broad (but not necessarily exhaustive) spectrum: new variations are frequently introduced. Over time, models have become more comprehensive and the risk assumed by providers and healthcare management organizations (HCMs) has increased.
Risk and VBC contract types. *BPCI: Bundled Payment for Care Improvement; **OCM: Oncology Care Model; ***MSSP: Medicare Shared Savings Program.
Figure 2 illustrates the two dimensions of risk that are accepted by a provider or HCM: the x-axis indicates increasing degrees of financial risk, from none (pay for performance or pay for quality which represent supplemental payments on top of regular provider reimbursement) to capitation (which represents the potential for significant gain but also losses). The y-axis illustrates the extent of the services at risk incorporated in the contract, which may range from a risk limited to a single episode of care only (for example knee surgery) to population risk. Population risk in turn may be limited to certain services only (for example for maternity services those associated with the pregnancy only) to “total cost of care” in which the provider or HCM accepts financial risk for all expenses incurred by the target population.
As we discussed above, the original reimbursement model was fee-for-service: each time the patient received a service from a physician, hospital or pharmacist a bill was generated and then paid by the patient or the payer (or both). As this system began to impose a financial strain on payers, different models evolved, beginning with payment for quality. Payment for quality models addressed the “gaps in care” issue identified in [5], as well as attempting to limit the provision of excess and ultimately redundant services. While these models resulted in improvement in quality metrics (such as HEDIS https://www.ncqa.org/hedis/) they did not lead to significant reduction in healthcare costs. Closely allied to pay for quality models is pay for performance in which physicians are rewarded for patient metrics (such as mammograms for women, eye and foot exams for people with diabetes, etc.).
The big breakthrough in terms of financial risk transfer occurred with disease management programs in the early 2000s. Insurers that purchased disease management programs from vendors needed assurance that the programs would reduce medical cost. Lacking convincing randomized studies, vendors and payers contracted around a financial outcome; initially vendors put a portion of their fees at risk of a favorable financial outcome. Later models allowed vendors to share in actual savings generated (gain-sharing), to the extent that the vendor reduced costs below a target. There are different variations of gain-sharing models, with some being one-sided (only positive savings are shared) while others are two-sided (if costs increase relative to the target, the vendor must reimburse some portion of the excess). More discussion of these models and methods for measuring financial outcomes may be found in Duncan [7].
CMS introduced another value-based arrangement with its Bundled Payment initiative in which organizations entered into payment arrangements that included financial and performance accountability for episodes of care. These models aimed to increase quality and care coordination at a lower cost to CMS. Providers continue to bill CMS in the usual way, with a retrospective reconciliation of claims against a previously agreed upon target price. Depending on which of four payment models the provider enters into, the provider receives a payment that covers hospital only or hospital plus physician services. To the extent that the provider is able to manage the financial risk, it keeps the financial margin (in some models the provider is responsible for reimbursing CMS if costs exceeded target prices). See [8] for a description of the different BPCI models and the results of evaluations.
The Affordable Care Act (2010) [9] introduced Accountable Care Organizations (ACOs): provider groups that accept payment risk for their attributed populations in return for the opportunity to share savings when costs are reduced below an adjusted benchmark. In the original model providers only accepted upside risk (shared savings only). In later models providers could achieve a greater share of savings but at the cost of having to share also in losses. More detail may be found in [10]. ACO arrangements exist among all payers and payer types, including commercial insurers, traditional Medicare and Medicaid. CMS’s Oncology Care Model is a similar initiative but limited to cancer patients undergoing treatment by oncologists.
All these models involve some sharing of risk between the payer and providers. Full risk transfer is achieved with capitated models. With capitation the provider accepts full financial responsibility for all costs of a population (or sub-population, for example primary care only).
Value-based contracting requires a clinical organization that is different to the traditional practice management. Several texts discuss necessary re-organization of clinical practice and the necessary infrastructure [11, 12, 13, 14, 15, 16] etc. For the purposes of this chapter we assume that clinical delivery has been optimized and the provider of clinical services is ready to begin the financial modeling required to negotiate contract with a payer.
We illustrate the contract modeling and implementation steps in Figure 2.
Successful value-based contracting requires sophisticated analytics, and at the heart of the analysis is a robust data warehouse that integrates claims data, preferably with clinical data. The importance of claims data is often overlooked by providers, with their focus on clinical data, charts and electronic medical records. Healthcare claims in the US system are the basis of reimbursement, containing valuable information about the nature and diagnosis of a patient’s condition, the treatment applied by the physician or health system, the place of service and (in the case of drugs) the therapeutic class and dosage of a drug. Complete medical and drug claims—claims that include all providers utilized by a population—are essential for financial contracting but are seldom present in provider records: they must be obtained from a payer. Providers rarely have as complete a view of the patient’s care that the payer has (due to its contracts with multiple providers).4 Once a robust warehouse has been built, it is possible to begin the five steps to successful value-based contracting (Figure 3).
Five steps to successful value-based contracting.
For any start-up or mature company wishing to enter a value-based contract, the essential first step is to assess the financial opportunity. Payers are subject to multiple new opportunities weekly; a provider or HCM must make a compelling economic case to gain attention. The compelling economic case begins with
Frequency: the condition or procedure must occur with sufficient frequency to be of concern to the payer.
Severity: the cost imposed by the condition or procedure must be high enough to command the payer’s attention.
Some conditions impose one but not the other of these elements: for example, in an employer population, an episode of stroke is very high cost but occurs with sufficiently low frequency that the average employer may not have experienced a recent stroke in its population. Employees that suffer strokes experience lengthy episodes, during which another payer (such as Social Security disability, or a retirement plan) may become responsible for reimbursement. As a result, the employer may not view strokes as a concern. Cancer, in the other hand, imposes high costs episodically but with cancer diagnoses occurring frequently enough for a payer to be concerned with managing cancer costs.
Modeling opportunity, particularly for individual diagnoses, requires access to large databases. These may be purchased from data vendors, or providers/HCMs may contract with a consultant for this phase of work.
Pricing a value-based contract requires an estimate of the value that will be created by a program, device or other intervention (in addition to estimates of the cost of delivery of the VBC solution). Value estimation requires identification of the patient’s current treatment pathway and a projection of an alternative pathway once a VBC solution is implemented. The treatment pathway is a transition or multi-state model that identifies different branches that a patient can follow together with the probability and cost of each different branch. Figure 4 is an example of a simple multi-state model of a specific condition for which the patient can choose to receive treatment in an urgent care setting or a hospital Emergency Department (ED). Depending on the severity of the condition, a patient in the urgent care setting could be sent home or referred to ED. A patient seeking care in the ED could be tested and sent home or, after referral for further evaluation, either sent home or admitted to hospital.
Current patient pathway.
A detailed claims database will allow the analyst to assess the services, their frequency and the pathway that a typical patient follows. As Figure 4 shows, we associate transition frequencies with the different states, as well as the cost of treatment at different stages. A disruptive device or intervention in this model would reduce the frequency of transition to higher-cost pathways. Figure 4 is a simple pathway; pathways can become extremely complex, in which case some simplification will be necessary. Complexity arises not because of the variety of settings but because the services that the patient receives may be delivered in a different order (for example for some cancer patients, oncology may be delivered first, followed by surgery while for other patients, surgery may be performed first, followed by oncology). Episodes of care that involve physician or auxiliary providers (for example physical therapy) may involve a few treatments over time, to as many as one or two per week.
Once the typical patient pathway is defined and its frequencies and costs have been developed, the analyst can develop an alternative pathway, assuming the provider/HCM intervention has been applied. The alternative pathway illustrates the disruption to the current standard of practice that the provider intervention generates; this may be estimated from prior studies or simply by clinicians who understand the intervention. The difference between the current and proposed pathways, however, is the source of the estimation of the provider’s or HCM’s economic value added. The result of this analysis is an economic model which is the basis of the HCM’s pricing. The economic model is developed by comparing frequencies and unit costs under the current and proposed pathways.
Understanding pathways is a critically important component of the financial estimation process. Providers/HCMs often spend time and effort on the financial estimation phase and assume that the actual work of caring for patients and driving behavior change will take care of itself, if left to clinicians. Clinicians, however, need to know where and how they can perform interventions, with what patients and what outcome to expect. Operationalizing the model to achieve the projected savings is as important as understanding the opportunity. Pathway analysis can provide valuable input to this process because it provides a basis for breaking savings assumptions into drivers/components. We will return below to considering the implementation of a value-based contract.
The Economic Model (Table 1) illustrates the estimation of the value created by the sample intervention illustrated in the pathways in Figure 5, which moves patients from the Emergency Dept. to Urgent Care, as well as more accurately identifies those patients that may safely be sent home after evaluation.
Current patient pathway | Proposed patient pathway | |||||
---|---|---|---|---|---|---|
Setting | Patients | Charge | Cost | Patients | Charge | Cost |
Urgent care | 30 | $170 | $5100 | 70 | $170 | $11,900 |
Emergency | 70 | $750 | $52,500 | 30 | $750 | $22,500 |
Referred from UC | 27 | $750 | $20,250 | 35 | $750 | $26,250 |
ED evaluation | 67.9 | $1000 | $67,900 | 32.5 | $1000 | $32,500 |
Inpatient transfer | 6.79 | $30,000 | $203,700 | 6.79 | $30,000 | $203,700 |
TOTAL COST | $349,450 | $296,850 | ||||
Intervention | $0 | $250 | $25,000 | |||
Cost/patient | $3495 | $3269 | ||||
Savings % | 7.9% |
Economic model.
Proposed patient pathway.
Combining the predicted savings with the cost of delivery of the program allows the Provider/HCM to price its intervention in a manner that allows an appropriate margin for the HCM while also generating an acceptable ROI for the payer. The economic model also allows the HCM to price its contract: in this example the projected savings after intervention charges is 7.9% of projected costs. For a 50/50 gainsharing contract the HCM could each expect savings of 3.95%. This is a point estimate, however, subject to considerable volatility. Before entering into a contract the parties will want to evaluate the uncertainty around the point estimate, which we discuss next.
In Step 2 we created the current and proposed patient pathways, estimated the value created by the HCM and the basic pricing parameters. However, this estimate is a mean; we do not know the variance around the estimated outcome. Variance estimation is important for healthcare models: healthcare claims are highly variable for two reasons. First, the distribution of healthcare claims itself is a convolution of two highly-variable distributions, frequency and severity. Second, outcomes of a healthcare program are subject to performance risk. Step 3 begins with modeling the distribution of the predicted outcome. Additionally, there are multiple variables involved in the predicted outcome; many of these variables can be controlled in order to limit the contract risk. The Risk Assessment step helps the analyst to understand the contribution of individual variables to the predicted outcome and to choose values in such as way as to mitigate some of the inherent stochastic risk of the contracted outcome. Figure 6 shows some of the variables that comprise a value-based contract that an analyst should consider when modeling contract risk.
Key parameters for a value-based contract.
Figure 6 shows that designing a value-based contract is a complex undertaking. While we will not discuss all the variables in Figure 6, we will discuss some key variables and use them to illustrate the complexity of the modeling that is required as part of the Value-based Contract pricing.
Risk assessment requires simulation of the distribution of outcomes. The provider/HCM will contract at a target rate or price assuming its performance will achieve a particular outcome level. In Table 1 this was illustrated as $2,969 per patient. The question to be addressed in the Risk Assessment phase is: what is the confidence interval around this estimate and how may variation be mitigated by choosing different values of the parameters in Figure 6?
Risk mitigation can be illustrated by looking at an example from the Medicare Shared-savings program, assuming that the provider/HCM is considering a contract with both upside and downside risk. The provider will want to maximize its chance of upside gains and minimize the chance of a downside loss (reimburse Medicare). In a recent studies [10, 17] the authors illustrate that even in the absence of an intervention there is a non-trivial risk that a provider will have to reimburse the payer simply because of the stochastic nature of claims, giving rise to the need for
Figure 7 illustrates this important concept. Note that Figure 7 illustrates stochastic (claims variability) risk only; in addition, the provider/HCM will be at risk of performance variability as well. Figure 7 simulates the outcome (calculated savings
ACO gain/(loss) distribution: 10,000 simulations.
One of the biggest challenges for providers/HCMs entering into value-based contracts is population size. This problem has become especially acute in recent years as providers focus more on specific conditions and sub-populations that may be relatively small or where the condition prevalence results in a small number of target patients. Figure 7 is an example of a 3,000 life population where a target condition could result in only a few hundred patients being managed. The variance in claims of a few hundred patients is significant; the variance may be mitigated with appropriate truncation and risk corridors but in small samples will remain a major risk to the provider/HCM. A number-needed-to-treat analysis could provide some guidance to the contracting parties regarding their potential variance and risk, but the answer is invariably (except in the case of large insurers) that the provider/HCM will need to manage a much larger population than available to be comfortable with the outcomes. In this case the parties should probably consider an alternative contractual form.
The risk corridor is only one variable that can be modeled; modeling the outcomes using the key variables from Figure 6 will give the provider/HCM a better idea of the risk that it undertakes and how to mitigate that risk—for example with risk corridors, different attribution definitions, and stop-loss insurance.
Once the modeling is completed the contract terms will be known and it should be a straightforward matter to prepare a contract. Once the contract is signed, however, it is important that the provider/HMC prepare an implementation and operational plan with appropriate targets, preferably on a monthly basis. Contractors often lose sight of the fact that they are managing a risk contract, often with a one-year term. If the contractor does not adhere to a plan and falls behind, however, it is often impossible to make up patient engagement and cost-reduction numbers later in the contract year. For this reason a projection of the ultimate results and likely reconciliation on a regular basis is important. For some providers/HCMs (particularly those that are publicly traded) an estimate of the final gain/(loss) will also be required because of the need to set up a balance sheet reserve for any ultimate payable or receivable, and to demonstrate revenue recognition.
Operationalizing the contract also may require sophisticated modeling to identify at-risk patients, alert providers to changes in patient status and report on clinical gaps and gap closure. Delivery of programs that rely on clinical resources is also costly and requires that the contractor maximize efficiency. A workflow system incorporating the latest real-time information for providers (if they are managing patients) or patients (self-management) is essential for efficiency and for achieving contracted outcomes. Monitoring the progress of the contract against the plan and reporting on the key performance indicators identified at Step 2 is essential to achieving successful outcomes.
Some models are relatively simple to administer and reconcile: capitated contracts for example may require no reconciliation because the provider is paid a capitated amount from which the provider derives its margin. Shared savings and bundled payment models, on the other hand, can be complicated to reconcile. One challenge with this type of contract is that reconciliation requires complete data, meaning that run-out claims5 are included in the calculation. Allowing for run-out often imposes a delay of 6 months or more post-contract period before complete claims are available. Reconciliation also requires the application of key contract terms: attribution, services, inclusions/exclusions, truncation and corridors etc.
Because value-based contracts are often very different from contract to contract, payers may need to administer contracts manually. This makes final reconciliation difficult both in terms of actual calculation and payments. Reconciliation payments may be delayed as much as 2 years from contract inception. A provider/HCM will need to plan for this delay in receipt of revenue, and have sufficient capital to carry through to the final reconciliation.
Payments are an important part of the Value-based Contract. They represent the result of an intervention, and being part of the operation of the contract, are not a component of the five analytical steps discussed above. Their importance to a contractor and a payer, however, make it important to discuss payments.
A successful contract will result in a payment from the payer to the provider/HCM. Some models such as capitation and bundled payments result in prospective payments: the provider/HCM receives a fixed amount and there is usually no reconciliation or further exchange of funds. For performance-based contracts such as shared-savings or pay-for-performance, a reconciliation will be necessary to calculate amounts owed or owing. Administration of claims for these contracts can be complicated because providers will submit claims in the normal way to the payer, who must then turn off payment (because the provider will be reimbursed from a pool of funds at reconciliation). It is clearly not satisfactory to the provider/HCM to wait 18 months for reimbursement. The challenge of administering partial payments (or payments after the fact) from a typical claims system, particularly in a payer with multiple different contracts, can be challenging to the payer. In many cases these contracts are administered manually. Solutions such as the application of Stochastic Control processes, in which the ultimate settlement payment is continually estimated and payments are made on account of the ultimate payments offer some promise as a way to satisfy provider/HCM need for near real-time payments. That, however, is a topic for a different chapter.
Value-based contracts offer providers of healthcare services an opportunity for higher rewards than traditional payment models, but with considerable additional risk. Risk comes in many forms, from definitions to execution. This chapter has not touched on performance risk, which is the province of other professionals, mostly clinical. But aside from clinical risk a provider/HCM that accepts value-based risk is open to numerous other forms of risk. The good news is that with appropriate planning and modeling these risks can be managed and mitigated. Doing so will allow the provider or healthcare management organization to capitalize on a growing trend in healthcare finance.
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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",slug:"cesar-lopez-camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]},onlineFirstChapters:{paginationCount:3,paginationItems:[{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81188",title:"Structure- and Design-Based Difficulties in Recombinant Protein Purification in Bacterial Expression",doi:"10.5772/intechopen.103958",signatures:"Kubra Acikalin Coskun, Nazlıcan Yurekli, Elif Cansu Abay, Merve Tutar, Mervenur Al and Yusuf Tutar",slug:"structure-and-design-based-difficulties-in-recombinant-protein-purification-in-bacterial-expression",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yusuf",surname:"Tutar"},{name:"Nazlican",surname:"Yurekli"},{name:"Merve",surname:"Tutar"},{name:"Mervenur",surname:"Al"},{name:"Elif Cansu",surname:"Abay"},{name:"Kubra",surname:"Acikalin Coskun"}],book:{title:"Protein Detection",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"79353",title:"Protein Detection in Clinical Diagnosis and Management of Prevalent Neurodegenerative Diseases and Metabolic Disorders",doi:"10.5772/intechopen.101051",signatures:"Ohanube A.K. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"onlineFirst.detail",path:"/online-first/80812",hash:"",query:{},params:{id:"80812"},fullPath:"/online-first/80812",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()