Comparison of central and local HVAC systems.
\r\n\tThe purpose of the book is to bring together the latest knowledge about genetic diversity by presenting the studies of some of the scientists who are engaged in development of new tools and ideas used to reveal genetic diversity, often from very different perspectives. The book should prove useful to students, researchers and experts in the area of biology, medicine and agriculture.
",isbn:"978-1-80356-945-1",printIsbn:"978-1-80356-944-4",pdfIsbn:"978-1-80356-946-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"0b1e679fcacdec2448603a66df71ccc7",bookSignature:"Prof. Mahmut Çalışkan and Dr. Sevcan Aydin",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11643.jpg",keywords:"PCR Based Methods, Protein Based Methods, Sequencing, Conservation of Genetic Resources, Natural Variation, Molecular Markers, Genetic Manipulation in Animals, Resistance to Disease, Genetic Manipulation in Plants, Use of Microorganisms in Biotechnology, Genetic Differentiation, Gene Therapy and Gene Editing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 7th 2022",dateEndSecondStepPublish:"May 5th 2022",dateEndThirdStepPublish:"July 4th 2022",dateEndFourthStepPublish:"September 22nd 2022",dateEndFifthStepPublish:"November 21st 2022",remainingDaysToSecondStep:"14 days",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Professor of genetics and molecular biology and Head of Biotechnology division at İstanbul University in Turkey whose main research areas include plant molecular genetics, microbial biotechnology and characterization and biotechnological use of halophilic archaeal strains.",coeditorOneBiosketch:"Associate Professor of Biotechnology Division in Department of Biology at Istanbul University in Turkey whose main research areas include genetics, environmental biotechnology and bioengineering.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"51528",title:"Prof.",name:"Mahmut",middleName:null,surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan",profilePictureURL:"https://mts.intechopen.com/storage/users/51528/images/system/51528.png",biography:"Mahmut Çalışkan is a Professor of Genetics and Molecular Biology in the Department of Biology, Biotechnology Division, Istanbul University, Turkey. 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\nHVAC systems are more used in different types of buildings such as industrial, commercial, residential and institutional buildings. The main mission of HVAC system is to satisfy the thermal comfort of occupants by adjusting and changing the outdoor air conditions to the desired conditions of occupied buildings [1]. Depending on outdoor conditions, the outdoor air is drawn into the buildings and heated or cooled before it is distributed into the occupied spaces, then it is exhausted to the ambient air or reused in the system. The selection of HVAC systems in a given building will depend on the climate, the age of the building, the individual preferences of the owner of the building and a designer of a project, the project budget, the architectural design of the buildings [1].
\nHVAC systems can be classified according to necessary processes and distribution process [2]. The required processes include the heating process, the cooling process, and ventilation process. Other processes can be added such as humidification and dehumidification process. These process can be achieved by using suitable HVAC equipment such as heating systems, air-conditioning systems, ventilation fans, and dehumidifiers. The HVAC systems need the distribution system to deliver the required amount of air with the desired environmental condition. The distribution system mainly varies according to the refrigerant type and the delivering method such as air handling equipment, fan coils, air ducts, and water pipes.
\nSystem selection depends on three main factors including the building configuration, the climate conditions, and the owner desire [2]. The design engineer is responsible for considering various systems and recommending more than one system to meet the goal and satisfy the owner of a building. Some criteria can be considered such as climate change (e.g., temperature, humidity, and space pressure), building capacity, spatial requirements, cost such as capital cost, operating cost, and maintenance cost, life cycle analysis, and reliability and flexibility.
\nHowever, the selection of a system has some constraints that must be determined. These constraints include the available capacity according to standards, building configuration, available space, construction budget, the available utility source, heating and cooling building loads.
\nThe basic components or equipment of an HVAC system that delivers conditioned air to satisfy thermal comfort of space and occupants and the achieve the indoor air quality are listed below [3]:
Mixed-air plenum and outdoor air control
Air filter
Supply fan
Exhaust or relief fans and an air outlet
Outdoor air intake
Ducts
Terminal devices
Return air system
Heating and cooling coils
Self-contained heating or cooling unit
Cooling tower
Boiler
Control
Water chiller
Humidification and dehumidification equipment
The major classification of HVAC systems is central system and decentralized or local system. Types of a system depend on addressing the primary equipment location to be centralized as conditioning entire building as a whole unit or decentralized as separately conditioning a specific zone as part of a building. Therefore, the air and water distribution system should be designed based on system classification and the location of primary equipment. The criteria as mentioned above should also be applied in selecting between two systems. Table 1 shows the comparison of central and local systems according to the selection criteria [3, 4].
\nCriteria | \nCentral system | \nDecentralized system | \n
---|---|---|
Temperature, humidity, and space pressure requirements | \nFulfilling any or all of the design parameters | \nFulfilling any or all of the design parameters | \n
Capacity requirements | \n\n
| \n\n
| \n
Redundancy | \nStandby equipment is accommodated for troubleshooting and maintenance | \nNo backup or standby equipment | \n
Special requirements | \n\n
| \n\n
| \n
First cost | \n\n
| \n\n
| \n
Operating cost | \n\n
| \n\n
| \n
Maintenance cost | \nAccessible to the equipment room for maintenance and saving equipment in excellent condition, which saves maintenance cost | \nAccessible to equipment to be located in the basement or the living space. However, it is difficult for roof location due to bad weather | \n
Reliability | \nCentral system equipment can be an attractive benefit when considering its long service life | \nReliable equipment, although the estimated equipment service life may be less | \n
Flexibility | \nSelecting standby equipment to provide an alternative source of HVAC or backup | \nPlaced in numerous locations to be more flexible | \n
Comparison of central and local HVAC systems.
Four requirements are the bases for any HVAC systems [4]. They need primary equipment, space requirement, air distribution, and piping, as shown in Figure 1.
\nHorizontal hierarchy representation of HVAC system requirements.
Primary equipment includes heating equipment such as steam boilers and hot water boilers to heat buildings or spaces, air delivery equipment as packaged equipment to deliver conditioned ventilation air by using centrifugal fans, axial fans, and plug or plenum fans, and refrigeration equipment that delivers cooled or conditioned air into space. It includes cooling coils based on water from water chillers or refrigerants from a refrigeration process.
\nSpace requirement is essential in shaping an HVAC system to be central or local. It requires five facilities as the following:
Equipment rooms: since the total mechanical and electrical space requirements range between 4 and 9% of the gross building area. It is preferable to be centrally located in the building to reduce the long duct, pipe, and conduit runs and sizes, to simplify shaft layouts, and centralized maintenance and operation.
HVAC facilities: heating equipment and refrigeration equipment require many facilities to perform their primary tasks of heating and cooling the building. The heating equipment requires boiler units, pumps, heat exchangers, pressure-reducing equipment, control air compressors, and miscellaneous equipment, while the refrigeration equipment requires water chillers or cooling water towers for large buildings, condenser water pumps, heat exchangers, air-conditioning equipment, control air compressors, and miscellaneous equipment. The design of equipment rooms to host both pieces of equipment should consider the size and the weight of equipment, the installation and maintenance of equipment, and the applicable regulations to combustion air and ventilation air criteria.
Fan rooms contain the HVAC fan equipment and other miscellaneous equipment. The rooms should consider the size of the installation and removal of fan shafts and coils, the replacement, and maintenance. The size of fans depends on the required air flow rate to condition the building, and it can be centralized or localized based on the availability, location, and cost. It is preferable to have easy access to outdoor air.
Vertical shaft: provide space for air distribution and water and steam pipe distribution. The air distribution contains HVAC supply air, exhaust air, and return air ductwork. Pipe distribution includes hot water, chilled water, condenser water, and steam supply, and condenser return. The vertical shaft includes other mechanical and electrical distribution to serve the entire building including plumbing pipes, fire protection pipes, and electric conduits/closets.
Equipment access: the equipment room must allow the movement of large, heavy equipment during the installation, replacement, and maintenance.
Air distribution considers ductwork that delivers the conditioned air to the desired area in a direct, quiet, and economical way as possible. Air distribution includes air terminal units such as grilles and diffusers to deliver supply air into a space at low velocity; fan-powered terminal units, which uses an integral fan to ensure the supply air to the space; variable air volume terminal units, which deliver variable amount of air into the space; all-air induction terminal units, which controls the primary air, induces return air, and distributes the mixed air into a space; and air-water induction terminal units, which contains a coil in the induction air stream. All the ductwork and piping should be insulated to prevent heat loss and save building energy. It is also recommended that buildings should have enough ceiling spaces to host ductwork in the suspended ceiling and floor slab, and can be used as a return air plenum to reduce the return ductwork.
\nThe piping system is used to deliver refrigerant, hot water, cooled water, steam, gas, and condensate to and from HVAC equipment in a direct, quiet and affordable way. Piping systems can be divided into two parts: the piping in the central plant equipment room and the delivery piping. HVAC piping may or may not be insulated based on existing code criteria.
\nA central HVAC system may serve one or more thermal zones, and its major equipment is located outside of the served zone(s) in a suitable central location whether inside, on top, or adjacent to the building [4, 5]. Central systems must condition zones with their equivalent thermal load. Central HVAC systems will have as several control points such as thermostats for each zone. The medium used in the control system to provide the thermal energy sub-classifies the central HVAC system, as shown in Figure 2.
\nHorizontal hierarchy representation of the main types of central HVAC systems.
The thermal energy transfer medium can be air or water or both, which represent as all-air systems, air-water systems, all-water systems. Also, central systems include water-source heat pumps and heating and cooling panels. All of these subsystems are discussed below. Central HVAC system has combined devices in an air handling unit, as shown in Figure 3, which contains supply and return air fans, humidifier, reheat coil, cooling coil, preheat coil, mixing box, filter, and outdoor air.
\nEquipment arrangement for central HVAC system.
The thermal energy transfer medium through the building delivery systems is air. All-air systems can be sub-classified based on the zone as single zone and multizone, airflow rate for each zone as constant air volume and variable air volume, terminal reheat, and dual duct [5].
\nA single zone system consists of an air handling unit, a heat source and cooling source, distribution ductwork, and appropriate delivery devices. The air handling units can be wholly integrated where heat and cooling sources are available or separate where heat and cooling source are detached. The integrated package is most-commonly a rooftop unit and connected to ductwork to deliver the conditioned air into several spaces with the same thermal zone. The main advantage of single zone systems is simplicity in design and maintenance and low first cost compared to other systems. However, its main disadvantage is serving a single thermal zone when improperly applied.
\nIn a single zone all-air HVAC system, one control device such as thermostat located in the zone controls the operation of the system, as shown in Figure 4. Control may be either modulating or on–off to meet the required thermal load of the single zone. This can be achieved by adjusting the output of heating and cooling source within the packaged unit.
\nAll-air HVAC system for single zone.
Although few buildings can be a single thermal zone, a single zone can be found in several applications. One family residential buildings can be treated as single zone systems, while other types of residential buildings can include different thermal energy based on the occupation and building structure. Movements of occupants affect the thermal load of the building, which results in dividing the building into several single zones to provide the required environmental condition. This can be observed in larger residences, where two (or more) single zone systems may be used to provide thermal zoning. In low-rise apartments, each apartment unit may be conditioned by a separate single zone system. Many sizeable single story buildings such as supermarkets, discount stores, can be effectively conditioned by a series of single zone systems. Large office buildings are sometimes conditioned by a series of separate single zone systems.
\nIn a multi-zone all-air system, individual supply air ducts are provided for each zone in a building. Cold air and hot (or return) air are mixed at the air handling unit to achieve the thermal requirement of each zone. A particular zone has its conditioned air that cannot be mixed with that of other zones, and all multiple zones with different thermal requirement demand separate supply ducts, as shown in Figure 5. Multi-zone all-air system consists of an air handling unit with parallel flow paths through cooling coils and heating coils and internal mixing dampers. It is recommended that one multi-zone serve a maximum of 12 zones because of physical restrictions on duct connections and damper size. If more zones are required, additional air handlers may be used. The advantage of the multi-zone system is to adequately condition several zones without energy waste associated with a terminal reheat system. However, leakage between the decks of air handler may reduce energy efficiency. The main disadvantage is the need for multiple supply air ducts to serve multiple zones.
\nAll-air HVAC system for multiple zones.
A terminal reheat all-air system is a multiple zone, which considers an adaptation of single zone system, as shown in Figure 6. This can be performed by adding heating equipment, such as hot water coil or electric coil, to the downstream of the supply air from air handling units near each zone. Each zone is controlled by a thermostat to adjust the heat output of heating equipment to meet the thermal condition. The supply air from air handling units is cooled to the lowest cooling point, and the terminal reheat adds the required heating load. The advantage of terminal reheat is flexible and can be installed or removed to accommodate changes in zones, which provides better control of the thermal conditions in multiple zones. However, the design of terminal reheat is not energy-efficient system because a significant amount of extremely cooling air is not regularly needed in zones, which can be considered as waste energy. Therefore, energy codes and standards regulate the use of reheat systems.
\nSingle duct system with reheat terminal devices and bypass units.
The dual duct all-air system is a terminal-controlled modification of the multi-zone concept. A central air handling unit provides two conditioned air streams such as a cold deck and a hot deck, as shown in Figure 7. These air streams are distributed throughout the area served by the air handling unit in separate and parallel ducts. Each zone has a terminal mixing box controlled by zone thermostat to adjust the supply air temperature by mix the supply cold and hot air. This type of system will minimize the disadvantages of previous systems and become more flexible by using terminal control.
\nAll-air HVAC dual-duct system.
Some spaces require different airflow of supply air due to the changes in thermal loads. Therefore, a variable-air-volume (VAV) all-air system is the suitable solution for achieving thermal comfort. The previous four types of all-air systems are constant volume systems. The VAV system consists of a central air handling unit which provides supply air to the VAV terminal control box that located in each zone to adjust the supply air volume, as shown in Figure 8. The temperature of supply air of each zone is controlled by manipulating the supply air flow rate. The main disadvantage is that the controlled airflow rate can negatively impact other adjacent zones with different or similar airflow rate and temperature. Also, part-load conditions in buildings may require low air-flow rate which reduces the fan power resulting in energy savings. It may also reduce the ventilation flow rate, which can be problematic to the HVAC system and affecting the indoor air quality of the building.
\nAll-air HVAC systems with VAV terminal units.
In an all-water system, heated and cooled water is distributed from a central system to conditioned spaces [4, 5]. This type of system is relatively small compared to other types because the use of pipes as distribution containers and the water has higher heat capacity and density than air, which requires the lower volume to transfer heat. All-water heating-only systems include several delivery devices such as floor radiators, baseboard radiators, unit heaters, and convectors. However, all-water cooling-only systems are unusual such as valance units mounted in the ceiling. The primary type that is used in buildings to condition the entire space is a fan-coil unit.
\nFan-coil unit is considerably small unit used for heating and cooling coils, circulation fan, and proper control system, as shown in Figure 9. The unit can be vertically or horizontally installed. The fan-coil unit can be placed in the room or exposed to occupants, so it is essential to have appropriate finishes and styling. For central systems, the fan-coil units are connected to boilers to produce heating and to water chillers to produce cooling to the conditioned space. The desired temperature of a zone is detected by a thermostat which controls the water flow to the fan-coil units. In addition, occupants can adjust fan coil units by adjusting supply air louvers to achieve the desired temperature. The main disadvantage of fan-coils is ventilation air and only can be solved if the fan-coil units are connected to outdoor air. Another disadvantage is the noise level, especially in critical places.
\nAll-water system: fan-coil units.
Air-water systems are introduced as a hybrid system to combine both advantages of all-air and all-water systems [5]. The volume of the combined is reduced, and the outdoor ventilation is produced to properly condition the desired zone. The water medium is responsible for carrying the thermal load in a building by 80–90% through heating and cooling water, while air medium conditions the remainder. There are two main types: fan-coil units and induction units.
\nFan-coil units for air-water systems are similar to that of all-water systems except that the supply air and the conditioned water are provided to the desired zone from a central air handling unit and central water systems (e.g., boilers or chillers). The ventilation air can be separately delivered into space or connected to the fan-coil units. The major types of fan-coil systems, are 2 pipes or 4-pipes systems, as shown in Figure 10.
\nAir-water HVAC system using fan coil units with 4-pipes configuration.
Induction units are externally similar to fan-coil units but internally different. An induction unit induces the air flow in a room through cabinet by using high-velocity airflow from a central air handling unit, which replaces the forced convection of the fan in the fan-coil by the induction or buoyancy effect of the induction unit, as shown in Figure 11. This can be performed as mixing the primary air from the central unit and the secondary air from the room to produce a suitable and conditioned air into the room/zone.
\nAir-water HVAC system using induction units.
Water-source heat pumps are used to provide considerable energy savings for large building under the extreme cold weather [6]. A building of various zones can be conditioned by several individual heat pumps since each heat pump can be controlled according to the zone control. A centralized water circulation loop can be used as a heat source and heat sink for heat pumps. Therefore, heat pumps can act as the primary source of heating and cooling. The main disadvantage is the lack of air ventilation similar to the all-water systems as in fan-coil units. For a heating process, the boiler or solar collectors will be used to supply heat to the water circulation, while a cooling tower is used to reject heat collected from the heat pumps to the atmosphere. This system does not use chillers or any refrigeration systems. If a building requires a heating process for zones and cooling process for other zones at the same time, the heat pump will redistribute heat from one part to another with no need for a boiler or cooling tower operation,
\nHeating and cooling panels are placed on floors or walls or ceilings where can be a source of heating and cooling [7]. It also can be called as radiant panels. This type of system can be constructed as tubes or pipes impeded inside the surface where the cooling or heating media is circulated into the tubes to cool or heat the surface. The tubes are contacted to the adjacent large surface area to achieve the desired surface temperature for cooling and heating process. The heat transfer process is mainly by the radiation mode between the occupants and the radiant panels, and the natural convection mode between the air and panels. Temperature restriction is recommended for radiant floor panels, a range of 66–84°F, to achieve thermal comfort for occupants (ASHRAE Standard 55). Radiant ceiling or wall panels can be used for cooling and heating process. The surface temperature should be higher than the air dew point temperature to avoid condensation on the surface during the cooling process. Also, the maximum surface temperature is 140°F for ceiling levels at 10 ft. and 180°F for ceiling levels at 18 ft. This temperature is recommended to avoid too much heating above occupants’ heads.
\nThe installation of such systems is often expensive compared to other types as mentioned above, but they can be useful and has a lower running cost mainly because of the surface temperature restriction. A control signal is connected to the thermostat of each zone to manipulate the medium temperature to condition the space. The used medium can be refrigerant or water mixing with inhibited glycol (anti-freeze) instead of plain water to prevent icing inside the tubes for the cooling process. The main advantage is no space required, only a few inches for the panels to be installed and no more collected dirt in the standard ceiling or the ductwork. Many designs are available to produce attractive panels.
\nSome buildings can have multiple zones or have a large, single zone, which needs central HVAC systems to serve and provide the thermal needs [4, 5]. However, other building may have a single zone which needs equipment located inside the zone itself, such as small houses and residential apartments. This type of system is considered as local HVAC systems since each equipment serving its zone without crossing boundaries to other adjacent zones (e.g., using an air conditioner to cool down a bedroom, or using an electrical heater for the living room). Therefore, a single zone requires only one-point control point connected to a thermostat to activate the local HVAC system. Some buildings have multiple local HVAC systems as proper equipment serving specific single zones and controlled by the one-point control of the desired zone. However, these local systems are not connected and integrated to central systems, but still part of a large full-building HVAC systems. There are many types of local HVAC systems as shown in Figure 12.
\nHorizontal hierarchy representation of the main types of local HVAC systems.
A single zone will require a complete, single package of heating system which contains heat source and distribution system. Some examples include portable electric heaters, electric resistance baseboard radiators, fireplaces and wood stoves, and infrared heaters [8].
\nLocal cooling systems can include active systems as air-conditioning systems that provide cooling, a proper air distribution inside a zone, and control of humidification, and natural systems as convective cooling in open window, evaporative cooling in fountains [5, 6].
\nLocal ventilation systems can be forced systems by using devices such as window fan to allow air movement between outdoor and a single zone without changing in the thermal environment of the zone. Other systems used for ventilation are air circulation devices such as desk or paddle fans to improve thermal comfort of the space by allowing the heat to be transferred by conventional mode [5, 6].
\nA local air conditioning system is a complete package that can contain cooling and heating source, a circulation fan, a filter, and control devices. There are three main types listed below [5, 6].
\nThis system is a packaged device consisting of a vapor compression refrigeration cycle that contains a compressor, a condenser, an expansion valve, and an evaporator, in addition to a fan, a filter, control system and housing. Window air-conditioners can be installed in a framed or unframed opening in building walls and in window openings without any ductwork and distribution the cooling or heating air effectively inside the conditioned space. The air conditioning contains both evaporator and condenser where the condenser is located outside the space while the evaporate is inside the space, however, it serves the entire single zone with the thermal requirements. The heating process can be achieved by adding electric resistance coil in the air conditioning or reversing the refrigeration cycle to act as a heat pump. Many feature designs are produced to provide aesthetical values and improve the quality and response.
\nIt is similar to window air conditioners from the equipment perspective, but it is designed for commercial buildings. It is installed on the exterior wall of the building and generally located near the floor-wall intersection, as shown in Figure 13. Every single zone will contain one unitary air-conditioner as in each guest room in many hotels.
\nUnitary air-conditioner package.
It consists of a vapor compression refrigeration cycle; heat source such as heat pump and electric resistance; an air handler such as dampers, filter, and fan; and control devices, as shown in Figure 14. This system may be connected to ductwork and serve a large-size single zone that cannot be served by unitary or window air conditioners.
\nPackaged rooftop air-conditioning unit.
The split systems contain two central devices [5, 6]: the condenser, located outdoor, and the evaporator, located indoors. The two devices are connected by a conduit for refrigerant lines and wiring. This system solves some issues of small-scale single-zone systems since the location and installation of window, unitary or rooftop air conditioners may affect the esthetic value and architectural design of the building. The split systems can contain one condenser unit and connected to multiple evaporator units to serve multiple zones as possible under same conditions or different environmental conditions.
\nThis chapter presents the types of HVAC systems. HVAC systems have several requirements including primary equipment such as heating equipment, cooling equipment, and delivery equipment; space requirement such as HVAC facilities, equipment room, and vertical shaft; air distribution; and piping. Type of HVAC systems can be divided into central HVAC systems and local HVAC systems. This classification depends on zone types and the location of HVAC equipment. The central HVAC systems can serve multiple and single zones and locate away from the building, which needs distribution devices. They also can be sub-classified into all-air HVAC systems, air-water systems, all-water systems, water-source heat pumps, and heating and cooling panel systems. The local HVAC systems are mostly placed inside or adjacent to the living spaces and serve one single zone. They consist of local heating systems, local air-conditioning systems, local ventilation systems, and split systems.
\nThe major form of stored energy as carbohydrate in plants is Starch. It is a naturally occurring biopolymer consisting of a mixture of highly branched amylopectin and linear amylose residues. The two alpha-glucan residues make up 98–99% of the total net weight of starch [1] Amylopectin residue is made up of linear D-glucopyranose chains linked by O-α-(1 → 4) glycosidic bonds and branching occurring as O-α-(1 → 6) glycosidic bonds. Amylopectin biopolymers are brittle. On the other hand, amylose residue has O-(1 → 4)-α-Dglucan linkages and is film-forming [2].
Naturally occurring starch has limited industrial applications its poor functionality such as poor water solubility at room temperature, retrogradation of its paste or gel, texture and taste. The functionality of starch can be modified through physical, chemical and/or genetic processes [3]. Due to the reactive nature of its monomers which is mainly as a result of their free hydroxyl (▬OH), starch is easily modified to attain required functionalities for industrial purposes. For instance, if heated to high temperatures and in the presence of a plasticizer like glycerol, it exhibits comparable melt and flow characteristics as regular synthetic thermoplastic [4]. Undesirable characteristics such as hydrophilicity and low tensile strength are mitigated by introduction of hydrophobic fillers and materials that could enhance tensile strength. Likewise, different materials are used to improve thermal stability, plasticity and mechanical strength required in packing/packaging materials Advancement in material science which created thermoplastic starch has made starch a veritable resource with tensile applications in packaging and mechanical parts [5].
The ability to modify starch into biomaterials of different functionality has made it one of the most versatile and renewable natural polymer in existence. As a major type of food, it could be modified to enhance flavor, texture, thickness, taste, stability and/or shelf-life. Thus, it has found industrial application in food and beverage industry as food products or additives for enhancing the texture, stability, shelf-life and quality of products. It malleability with new technologies such as nanotechnology has expanded its scope of application in health and pharmaceutical and cosmetics. Starch could be used as both excipients and drug delivery vehicle [6].
The starch industry is at the very heart of food production: supplying hundreds of ingredients for use in thousands of food products and animal feed. At the same time, starches play a vital role in a wide variety of products beyond food. Natural and modified food starches can be found in products and processes in the consumer products, pharmaceutical, energy, industrial and chemical sectors. With the world beginning a gradual shift away from fossil fuels as the primary engine of economic prosperity, there will be a larger opportunity for starch producers to contribute renewable, sustainable materials through the bioeconomy [7]. This chapter discusses the various industrial application of starch which if exploited economically could provide strong foundation for economic revolution.
Starch is the second most abundant renewable bioenergy resources after cellulose, with an estimated global production of over 56 million tons per annum since 2006 [8, 9]. A variety of plant serves as the sources of starch consumed by humans. Starch storage in these plants occurs in grains or root tubers. Although the list of these plants which are either cultivated or found in the wild are endless, the major sources of food starch include corn, cassava, sweet potato, wheat, and potato. Sorghum, barley, rice, millet, yam etc. serve as minor sources in different parts of the world [10, 11]. A huge number of unexploited sources exist and majority is in the wild. Table 1 shows the starch contents of some of these sources.
Source | Plant storage part | % starch content | References |
---|---|---|---|
Soft wheat | Cereal grain | 77.90 | [10] |
Hard wheat | Cereal grain | 77.40 | [10] |
Waxy rice | Cereal grain | 74.76 | [10] |
Millet | Cereal grain | 70.oo | [12, 13] |
Fonio millet | Cereal grain | 68.00 | [10] |
Sorghum | Cereal grain | 67.70 | [10] |
Cassava | Root | 65.71 | [10] |
Taro/cocoyam | Corm | 63.74 | [10, 14] |
White yam | Tuber | 58.02 | [10] |
Rye | Cereal grain | 58.00 | [10] |
Lesser yam | Tuber | 54.70 | [10] |
Barley | Cereal grain | 53.60 | [10] |
Sweet potato | Root | 52.54 | [10] |
Yellow yam | Tuber | 41.72 | [10] |
Potato yam | Tuber | 38.10 | [10] |
Sweet corn | Cereal grain | 36.23 | [10] |
Water yam | Tuber | 31.90 | [10] |
Bitter yam | Tuber | 20.48 | [10] |
Starch sources.
By 2050, the population of the world is projected to exceed 9 billion and the demand for food is expected to rise by 70%. With growing environmental concerns and concept of green economy, reliance on fossil resources for energy and raw materials for industrial use etc. has attracted critical evaluation, and the prospect of a new trajectory for bio-based raw materials has become more imminent. Starch which is one of the most abundant and affordable natural polymer poses a more reliable and sustainable substitute to the non-renewable, non-green, and exhaustible fossil sources. This opens prime opportunities for starch-based bio-economic revolution especially for countries with the right cultivation and production technologies for starch sources and starch-based products, respectively [7].
Starch can be used as biopolymers in many ways including as a raw material for human foods and animal feeds/feedstock, as bioethanol for food and fuel, as particulate filler and adhesive in paper and textile sizing, as well as bioplastics in packaging materials (Figures 1 and 2) [8, 9, 15]. It is also deployed in a wide array of other consumer goods in health and pharmaceuticals, and chemical sector. Corn starch product is used in 3-D printing inks, and emerging reports indicates its potential for nanomedicine technology as a tool for delivering treatments to specific sites. Some other categories of products include starch-based detergent products, starch-based binders, starch in biodegradable polymers, starch-based products for pharmaceuticals and cosmetics, and starch hydrolysates for fermentation [15].
Fermented and refined products from starch. (source: [
Industrial application of starch. (source: [
The food industry is very large and diverse, and includes the raw unprocessed food and the processed and modified ones. Central to world food production and sustainability is the starch industry. Native starch is eaten in unprocessed raw or cooked form as grain or cereal meals, and flour dough or mashes with soups and other forms of condiments, in many developing countries. In West Africa, cooked and mashed cassava (
The food industry is very mindful of safety of chemical residues hence not all types of native or modified starches are used in the foods. Some modified starches are used as binder in assaulted foods, ready-made meat and snack seasonings. Others are used as anti-sticking agents and dustings for chewing gum and bakery products, crisping coating for fried snacks, fillers to replace fats and in sauces or creams to enhance lusciousness in ice cream and salad dressings. Modified starches are also used as flavor encapsulating agents and emulsion stabilizers in beverages. They are used as creamers, in canned foods, foam stabilizer in marshmallows, gelling agents in gum drops and jelly gum, and as expanders in baked snacks and cereal meals [2]. Starch derived products are used for the production of animal feeds [15]. About 10–15% of corn produced in the US is processed annually for starch derived products by corn refiners. These starch derived products are used in across the food, beverage, healthcare, pharmaceutical and other sectors. This has a dominant multiplier effect on the United States economy [7].
The CRA 2019 report put US production volume of sweeteners from corn starch refining for 2018 at 14.45 mMt d.w. These include glucose syrups, high fructose corn syrups maltodextrins, dextrose, corn syrup solids etc. [16]. The many other forms of starch are now been adopted as substitute raw material for corn. These products find applications in foods, beverages and pharmaceuticals for taste, flavor, color and texture enhancements.
Ethanol is one of the most important organic solvent in the chemical industry. It is also the basic raw material for the wine, brewery and beverage industries. Due to energy fuel sustainability concern, the world is focusing on renewable energy include energy for renewable biological materials like starch. According to the World Integrated Trade Solution (WITS) data of the World Bank, the global volume of ethanol export in 2020 was over 14.2 billion liters, with a net weight of over 13.3 billion kg, valued at over $10.2 billion USD. While the volume of imports was 9.3 billion liters of 9.2 billion net weight and valued at $10 billion USD, with the top 10 importers as Netherlands, European Union, Germany, USA, Canada, Japan, Brazil UK, France and Korea Republic [17].
The production of ethanol from biological materials such as starch has gained interest in recent years because of the low-cost raw materials, starch, and the uncomplicated process involved. These processes, either chemically or biotechnologically based, are environmentally friendly. Bioethanol is already being used in many countries as octane enhancer for gasoline to produce gasohol. Starch from corn and cassava can be used for ethanol production. Due to concerns on quality, corn starch maintains a premium as the primary source of food and pharmaceutical grade starch and may not be very feasible for use as biofuel based on demand. However, sources like cassava may offer a ready source. Nigeria is currently the world’s biggest producer of cassava starch although almost 100% of it is consumed locally as food. The rising demand for biofuel offers countries like Nigeria opportunity for economic revolution in the production of biofuel from cassava. Adeleye et al. [18] has report an ethanol yield of 1.5 L of 78% (v/v) from 2.5 kg wet weight of cassava. Countries like South Africa and China are already at advance stages of developing cassava plantations for production of starch for industrial uses [19, 20]. According to the 2019 Corn Refiners Association (CRA) report, the US produced about 6.06 billion liters of Ethanol, and about 3.37 mMt of Starch in 2018 [21].
Adhesives are mostly used in wood panels production, leather works and paper and packaging. The global volume of adhesive consumed annually is over 3 billion kilograms, mostly from petroleum derived feedstock and other synthetic materials. Due to environmental and safety concerns, a lot of studies have been ongoing to develop bio-material based hot melt adhesives (HMAs) from starch and its modification derivatives, (poly)lactic acid, soy protein, lignin and tannin [22].
Wood panels are composite products made by bonding wood particles or fibers with adhesive binders to form a board, which may be medium density fiberboard (MDF) or high density fiberboard (HDF). These panels find applications in home, office and industrial building construction. Wood panel makers currently almost depend exclusively on formaldehyde and amino-based adhesives with high formaldehyde emission, and polymeric 4,4-diphenylmethane diisocyanate, which are synthetic products. Concerns for indoor emission of formaldehyde, a known human carcinogen, led to the development of low-emission melamine-fortified urea-formaldehyde adhesives and other adhesive that exclude formaldehyde. Urea has been the primary formaldehyde scavenger for wood-based panels. Environmental consideration has raised interests for more green adhesives from biodegradable polymers like starch, lignin, tannin and protein. Organic scavengers like tannin powder, charcoal and wheat flour have shown promising potentials in reducing formaldehyde emission. Bio-based adhesive for industrial use are few and expensive. Tannin and starch adhesive, soy protein based adhesive and lignin-based adhesive are available for limited application in panel production [23].
Adhesives from native starch rely on hydrogen bonds which is weaker than chemical bonds. Due to their hydrogen bonding, they easily bond with water molecules and are therefore readily soluble and not-water resistant. Crosslinking starch produced with synthetic reagents such as epoxy chloropropane, sodium borate, hexamethoxymethylmelamine, formaldehyde, and isocyanates, tends to give better bonding force and water resist [23, 24]. Although no economically viable bio-based crosslinker reagents for starch are available, research on hot melt adhesives prepared by crosslinking modified propionyl starch with glycerol and polyvinyl alcohol (PVOH) has shown improved tensile strength of up to 2.0 MPa. Hence starch still offers a viable potential for future researches in 100% bio-based adhesive for wood-based panels industry [22].
The global volume of production and consumption of hot melt adhesive is on the increase and is about 15–21%, with an annual consumption growth rate which is 1.5–2 times higher than other adhesives [22]. This presents a huge market potential for starch-based HMAs.
They separate corn kernels into their component parts to make hundreds of products that touch consumer lives in countless ways every day. For years, those ingredients have been used to make food taste better, cosmetics last longer, pharmaceuticals easier to swallow and plastics environmentally-friendly [7].
The fundamental physiochemical and functional properties of natural starches for instance their good biodegradability and safety, make them suitable for a wide array of health and pharmaceutical applications. Several types of modified starch polymers and their application in bone tissue technology as bone tissue engineering scaffolding [25, 26], drug delivery system as biodegradable nanomedicine-carrier based delivery system and implants [27, 28], and hydrogels have been studied by different scientists over the past few years [6]. Starch has also been demonstrated as a viable material for capping of nanoparticles from different metals like Au, Ag and Pt, because of their bio-tolerance and cost effectiveness [29]. It has also been demonstrated to have potentials for use as nanoparticles to stabilize emulsions, Pickering emulsions, which are useful in cosmetics, pharmaceuticals and foods [30]. Also, pharmaceutical grade starch from corn is use as coating and filler excipients in tablets and caplets as well as syrups in many pharmaceutical products. It is also applicable as disintegrating agents, carriers, lubricants, matrices for controlled release [15]. For its good qualities of being odorless, decolourisable, environmentally biodegradable and skin friendly, it is used in cosmetics and beauty products as emollients, humectants, thickeners, film forming agents and emulsifiers [15]. Many sources of natural starch have been study and found to be effective for the production of pharmaceutical grade starch.
Starch and its modified derivatives have been used in medicine as biodegradable films, inexpensive cure for athlete’s foot, anti-sticking agents, relief rashes caused by prickling heat, relief skin itches caused by shingles, relieves rash caused by baby diapers, wound dressing and bandages and used to treat gastric dumping syndromes in children. It is considered a safe alternative to cancer causing talcum baby powder, and used to remove excess oil from scalps and relieves itching in children [31].
Plastic pollution and the global push for a more sustainable environment towards eliminating the use of non-biodegradable materials and reduction of hazardous emission form toxic materials has refocused the worlds efforts towards the use of biodegradable plastics based on natural polymers such as starch, cellulose, lignin and chitosan [32]. The current global annual production of plastics is estimated at about 368 million tonnes, out of which about 1% is bioplastics. It is estimated that bioplastic production capacity will increase from 2.11 million tonnes in 2020 to about 2.87 million tonnes in 2025 [33].
The starch-based bioplastics thermoplastic starch (TPS or TS) is produced obtained from gelatinize starch and plasticizers which is subsequently tuned pellets by extrusion is useless as a material. It can also be produced from polymerization of polylactic acid obtained from starch-derived sugars fermentation. Bioplastics from starch can be used for producing compost bags and disposable plastic household wares [32]. The desire for more ecofriendly plastics gives a huge economic prospect to the growth of biodegradable natural polymer-based bioplastics market [33].
Carbonaceous foams (CFs) are used all over the world and find application in military, industrial and domestic use, such as heat exchanger, electrode materials, catalyst carrier, adsorption, vibration damping and impact or sound absorption, electromagnetic shielding, radar absorption, filtration, and aerospace material, etc. Carbon/carbonaceous materials are generally made from non-renewable raw materials like coal tar pitch, mesophase pitch and synthetic materials, at high temperature (above 1000°C) and high pressure (in MPa). Although other materials such as sucrose and tannin have been used, more cost effective biomaterials have been successfully investigated. A more energy efficient process of producing CFs with excellent compressibility and mechanical strength has been demonstrated by using starch as raw material. The production requires much lower temperature (<500°C) and lower pressure (about 190 Pa) than conventional approaches [34]. The world annual production of polysaccharides is in excess of 150,000 million tonnes. But the production of CFs from polysaccharides such as starch is still very much at low level. This gives good opportunity for economic exploitation.
In the industry, starch powder is used in textiles, paper, inks and paints. They serve as fast absorbent polymer in water treatment, as cleaning agent in detergents, as desiccants to prevent mildew from ruining paper documents in storage, as fabric stiffener and yarn sizing, remove wax from wooden furniture, and as organic pesticide [6, 15]. Starch based alkylpolyglucosides (APG) are used in detergents with superior skin compatibility.
The economy of the starch industry largely depends on the availability of sufficient volumes of raw materials and the value of the so-called co-products. During corn starch processing, for example, all components of the maize grain are valorized: after steeping and coarse crushing the germ is separated and yields the valuable maize germ oil while the steeping water is concentrated and sold as nutrient for fermentations. The oil press cake together with the corn gluten (protein) and the hulls (fiber), which are separated after fine grinding in additional refining steps from the pure starch granules, are utilized as components in animal feed. The starch as the main product is either dried and sold as native starch, or chemically modified to make it more suitable for more demanding end uses, or hydrolyzed to yield refinery products such as hydrolyzates (dextrin), glucose syrups, and high fructose syrups [31].
In wheat starch processing, the value of the vital gluten is an essential source of income and could be regarded as the head product. In contrast to cereal and pulse starch production, the extraction of root and tuber starches does not deliver co-products of comparable value. As the processes for the extraction are different for the mentioned crops the starch industry cannot easily switch from one source to the other in order to adapt to fluctuating market conditions both on the raw material and on the end products.
Statistics on starch production and export are only available for the US, UK, the European Union and a few other countries. According to a 2014 report, Africa consumes the least starch per capita, and accounts for just about 2% of the global consumption market of starch and its derivatives. The two leading raw materials, cassava and maize are mainly consumed as food. Production of derived products is concentrated in few countries, Nigeria, Egypt and South Africa, with South Africa in the lead. While maize is the general source of starch for food in Egypt and South Africa, cassava starch plays an equally significant role as food in Nigeria and the West African region [19, 35, 36].
Importation and cultivation of
The starch consumption per capita for 2012 was in the order of Africa < South America < Asia < Europe < North America. Country-wise is Nigeria < Egypt < Mexico < Turkey < Russia < UK < South Africa < China < US. Africa also consumes the least sweetener per capita. This is followed by Asia, South America, Europe and North America. Africa consumed less than 1 kg per person while North America consumed over 40 kg per person in 2012 [36]. This scenario has not changed significantly. South Africa produces over 280,800 tons of corn starch annually and is experimenting on local cultivation of
According to the International Federation of Starch Association (IFSA), starch and its derived products accounts for an annual revenue of $47.50 billion in the United States in 2020, and supported about 167,786 jobs to the tune of about $10.01 billion wages. It accounted for about $1.91 billion worth of US export with the value of starch only products amounting to about $339.62 million [7]. The overall industry impact on US economic output (direct and indirect impact) was estimated by the Corn Refiners Association (CRA) to be about $7.16 trillion annually with an average growth rate of about 6% between 2017 and 2019 (Figure 3), while the value of impact on export was about $149.19 billion annually with an average growth rate of about 0.77% (Figure 4). However, the industry impact of export actually grew at 4.5% between 2017 and 2018. The impact on jobs (Figure 5) and wages (Figure 6) was actually higher in terms of growth. Capital investments in starch manufacturing were about $20.62 billion and $20.28 billion annually in 2018 and 2019, respectively [16, 21]. The US data presents a good indication of the potential of starch-economy as an economic revolutionary tool for job creation and export revenue. This potential is estimated to be higher for developing economies with higher opportunities for more investment in both upstream and downstream starch products value chain.
Output economic impact of starch in the US, 2017–2019. (source: [
Starch and derivative export value of the US, 2017–2019.
Impact of starch industry on jobs in US, 2017–2019.
Impact of starch industry on wages in the US, 2017–2019.
In 20 of the 28 EU member states, the European starch industry’s 28 member companies process 24 million tons of EU agricultural raw materials into 11 million tons of starch-based ingredients and five million tons of proteins and fibers. Of starch-based ingredients, approximately 60% go to the food and beverage industry, and 40% to industrial applications (mainly to the paper, cardboard, pharmaceutical, and chemical industries as a renewable alternative to fossil fuel ingredients). Of the proteins and fibers, approximately 90% go to the animal feed industry and 10% to the food industry. The EU has 75 producers or plants and rely on Maize, wheat and starch potatoes, barley, rice, peas as feed stock to produce Native maize, wheat and potato starches, modified starches, maltodextrins, glucose syrups, dextrose, glucose fructose syrups, polyols, wheat gluten, other proteins. The industry supports 15,000 direct jobs, supports 100,000 indirect jobs, exports 1.6 billion Euros, and the annual industry turnover is 7.4 billion Euros [7]. The EU uses starch and starch products for confectionery, drinks, processed food, animal feeds, corrugating and paper making, pharmaceuticals and chemicals, as well as other non-food applications (Figure 7).
Uses of starch in the European Union (source: [
The Turkish starch industry contributes to local farming by processing 25% of locally grown maize from thousands of local farmers each year. The industry separates its starch from corn, drying it to native and modified starches or breaking it down to its sugars and other value-added products. Almost 100% of corn kernels are converted to economically valuable products. The industry supplies edible oils, fish, calf, lamb and poultry meat, paper, textiles and more to local and international food and beverage industries. With its wide-ranging portfolio, from basic to high-end products, the Turkish starch industry is competitive and has the capacity to grow. There are 9 producers which use maize as feed stock and produces Glucose and fructose syrups, native corn starch, modified corn starches, crystalline fructose, polyols, maltodextrins, corn gluten and feed, and ethanol. The industry supports 1,900 direct jobs and export over 400,000 tons annually.
Mexico has an evolving industry with annual output of between $300 million and $500 million USD. The industry supports 2,500 direct jobs and 7,500 indirect jobs. The brewing and paper markets depend largely on corn-based starch. The industry is growing due to investments in brewing capacity [7].
Founded in 1984, the China starch industry association has 280 members. Revolution in starch development has rebound in progressive development in the food, medicine, biology and chemical industries. It has also significantly contributed to growth of the national economy especially in agriculture where it has helped to sustain livelihood of local farmers through agro-economy. The annual industry output for starch and starch-based deep-processing products is estimated at 30.1 million tons and 16.3 million tons, respectively, from 170 producers. Major products include native starch, pregelatinized starch, chemically modified starch, starch sugar, polyols and ethanol, from feed stocks of corn, potato, cassava, sweet potato and wheat [7].
Starch development in Russia has put the country in an upward trajectory for economic revolution. For instance, the industry has 30 starch enterprises and 23 production plants. Ten of the Russia’s 23 plants are responsible for 90% of all starch products from Russia. Annual production of starch and derivatives rose from less than 180,000 tons in 2013 to over 1.3 million tons in 2020. 70% of this production figures were sweeteners (Figure 8). The industry has a cumulative average growth rate (CAGR) of 8.65, 8.69 and 8.65 for starch, sugary products and total starch-based products, respectively. Corn accounts for about 800 thousand tons, wheat about 500 thousand tons, and potatoes about 30 thousand tons. The industry has invested about $358.4 million between 2013 and 2020 (Figure 9). Table 2 provides Russian industry statistics on starch production and derived sugary products as obtained from Russian Federation Starch Union (RFSU) for 2013–2016 [39]. The 2015 import and export data is as provided in Table 3. The industry supports 4,000 jobs, has an annual output of $600 million and exports worth $28.5 million. The major products include native corn, wheat and potato starches, modified starches, glucose syrups, HFS, dextrins, maltodextrins, wheat and corn gluten, from the feed stock of corn, wheat, potatoes [7].
Russian industry development indicators in the period 2013–2020 (according to the strategy for the development of the food and processing industry of the Russian Federation for the period up to 2020) [
The volume of investments in the development of the Russian industry for the period 2013–2020.
Tons | 2013 | 2014 | 2015 | 2016 |
---|---|---|---|---|
Dextrin | 2547 | 2314 | 5216 | 7023 |
Starches, except modified | 173,340 | 197,605 | 213,452 | 224,214 |
Starch syrup | 372,383 | 173,340 | 437,033 | 464,349 |
Production in 2013–2016.
Products | Export in 2015 Rubles | Import in 2015 |
---|---|---|
Corn Starch | 12,538,346 | 11,404,606 |
Glucose Syrup (Patoca Starch Glucose) | 8,812,834 | 7,699,115 |
Other Starch | 0.988 | 141,900 |
Potato Starch | 708,104 | 14,878,026 |
Maniok Starch | — | 2,368,000 |
Rice Starch | 159,900 | |
Starches transformed into complex or simple ether | 353,555 | 62,628,181 |
Wheat starch | 341,147 | 3,181,534 |
Isoglucose | — | 2400 |
Other, including syrup maltose | 154,178 | 2,177,381 |
Dextrins | 79,205 | 448,292 |
Other | 50,720 | 1,919,326 |
Other starches modified | 2,090,376 | 8,583,020 |
Other rice starch | 300 | — |
Starch products export and import in 2015 in Russia federation.
The value of starch and starch derived products imported and exported globally in year 2020 was $20,367,050,000 and $19,251,015,000, respectively according to figures from Trade Map [35]. African import and export were $1,921,266,000 and $652,628,000 (Figure 10), respectively, representing about 9.4% and 3.3%, of global figures respectively. This deficit represents a huge investment opportunity in starch production for the entire world. Table 4 provides details of the starch products considered.
Comparison of value of imported and exported in year 2020.
Products code | Imported by Africa | Exported by Africa | Trade balance—Africa | Import by The World | Exported by The World | Trade balance—World | *AGR 2016–2020 |
---|---|---|---|---|---|---|---|
1101 | 615,881 | 302,215 | −313,666 | 4,577,813 | 4,663,167 | 85,354 | 1 |
1102 | 164,983 | 61,057 | −103,926 | 1,224,723 | 1,061,272 | −163,451 | 7 |
1103 | 244,138 | 188,835 | −55,303 | 1,228,918 | 1,141,939 | −86,979 | 4 |
1104 | 95,193 | 15,921 | −79,272 | 1,953,073 | 1,852,332 | −100,741 | 6 |
1105 | 123,077 | 1598 | −121,479 | 913,775 | 764,468 | −149,307 | 10 |
1106 | 11,303 | 15,724 | 4421 | 622,918 | 691,942 | 69,024 | 3 |
1107 | 471,918 | 24,550 | −447,368 | 3,692,577 | 3,424,305 | −268,272 | 1 |
1108 | 161,796 | 42,328 | −119,468 | 4,712,232 | 4,348,129 | −364,103 | 7 |
1109 | 32,977 | 400 | −32,577 | 1,441,021 | 1,303,461 | −137,560 | 0 |
1,921,266 | 652,628 | −1,268,638 | 20,367,050 | 19,251,015 | −1,116,035 |
Table of Africa and global starch trade in year 2020 in thousand US $ [35].
AGR means global annual growth rate for the products’ trade between 2016 and 2020 (% p.a).
Products code: 1101 (Wheat or meslin flour); 1102 (Cereal flours excluding wheat or meslin); 1103 (Cereal groats, meal and pellets); 1104 (Cereal grains otherwise worked, e.g. hulled, rolled, flaked, pearled, sliced or kibbled; germ); 1105 (Flour, meal, powder, flakes, granules and pellets of potatoes); 1106 (Flour, meal and powder of peas, beans, lentils and other dried leguminous vegetables of heading); 1107 (Malt, whether or not roasted); 1108 (starches; inulin); 1109 (Wheat gluten, whether or not dried).
The high four years AGR of 10 for the global trade in flour (1105) and 7 for both cereal flour (1102) and inulin (1108) is a pointed to rising demands for these products. The imbalance in trade in wheat (1101) and malt (1107) for Africa expose the gap in export and import to Africa (Table 4). These rising demands and trade deficits could be bridged through more investments in starch production.
Starch is an abundant natural polymer with great industrial versatility. Various sources including maize, wheat, cassava, potato, rice and millet, abound in different countries of the world. Many countries especially those in Africa have not fully realized their starch production capacity and export potentials for international trade. The negative world trade balance of about $1.12 trillion for starch means opportunity for more investment in starch production. Starch and inulin with the highest world trade imbalance, and Malt, cereal and wheat gluten with relatively high world trade imbalance, could benefit more in future investment prospect (Table 4). A closer analysis shows that Africa has a higher negative trade balance of about $1.27 trillion than the world. As bad as this may look for Africa, it presents a huge opportunity for investments in global starch production. But Africa will have to do more to reduce the widening trade imbalance in starch products, especially in wheat and malt.
The authors declare no conflict of interest.
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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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