Biological activities of some isolated actinobacteria.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"7778",leadTitle:null,fullTitle:"Noise and Vibration Control - From Theory to Practice",title:"Noise and Vibration Control",subtitle:"From Theory to Practice",reviewType:"peer-reviewed",abstract:"The book presents a collection of articles on novel approaches to problems of current interest in vibration control by academicians, researchers, and practicing engineers from all over the world. The book is divided into eight chapters and encompasses multidisciplinary areas within the scope of noise and vibration engineering, such as structural dynamics, structural mechanics, finite element modeling, vibration control, and material vibration. Noise and Vibration Control - From Theory to Practice is a useful reference material for all engineering fraternities, including undergraduate and postgraduate students, academicians, researchers, and practicing engineers.",isbn:"978-1-78984-771-0",printIsbn:"978-1-78984-770-3",pdfIsbn:"978-1-83962-272-4",doi:"10.5772/intechopen.77592",price:119,priceEur:129,priceUsd:155,slug:"noise-and-vibration-control-from-theory-to-practice",numberOfPages:162,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"c3f8f3f004d0c15a62d522752c6e9b3f",bookSignature:"Ehsan Noroozinejad Farsangi",publishedDate:"October 2nd 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7778.jpg",numberOfDownloads:7099,numberOfWosCitations:1,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:9,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 14th 2018",dateEndSecondStepPublish:"December 26th 2018",dateEndThirdStepPublish:"February 24th 2019",dateEndFourthStepPublish:"May 15th 2019",dateEndFifthStepPublish:"July 14th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"70678",title:"Dr.",name:"Ehsan",middleName:null,surname:"Noroozinejad Farsangi",slug:"ehsan-noroozinejad-farsangi",fullName:"Ehsan Noroozinejad Farsangi",profilePictureURL:"https://mts.intechopen.com/storage/users/70678/images/system/70678.jpg",biography:"Dr. Ehsan Noroozinejad Farsangi is currently an assistant professor in the Department of Earthquake and Geotechnical Engineering, Graduate University of Advanced Technology, Iran. Dr. Noroozinejad is the founder and chief editor of the International Journal of Earthquake and Impact Engineering, engineering editor for ASCE Natural Hazards Review, associate editor for ASCE Practice Periodical on Structural Design and Construction, IET Journal of Engineering, Frontiers in Built Environment: Earthquake Engineering, Open Civil Engineering Journal, and Journal of Applied Science and Engineering, and editor of the Journal of Reliability Engineering and Resilience. His main research interests include structural and geotechnical earthquake engineering, structural dynamics, computational dynamics, smart structures, solid and fracture mechanics, resilience-based design, reliability analysis, artificial intelligence, SSI, and vibration control in structures and infrastructure under extreme loading.",institutionString:"Graduate University of Advanced Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Graduate University of Advanced Technology",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"110",title:"Acoustical Engineering",slug:"engineering-acoustical-engineering"}],chapters:[{id:"67649",title:"Nonlinear Giant Magnetostrictive Actuator and Its Application in Active Control",doi:"10.5772/intechopen.86463",slug:"nonlinear-giant-magnetostrictive-actuator-and-its-application-in-active-control",totalDownloads:917,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The giant magnetostrictive actuator has great use in vibration control, but the linear model cannot fully describe its dynamic characteristics. In this chapter, based on the domain wall theory and piezomagnetic theory, a hysteresis nonlinear model is established to fully describe the actuator dynamic characteristics. In combination with the regularisation method, a sliding mode controller has been designed, and the giant magnetostrictive actuator is also studied in the application of active control. Experimental results show that the hysteresis nonlinear model proposed in the chapter can fully describe the actuator’s dynamic characteristics in a wider frequency band and the active control also has a much better isolation effect than the passive vibration; it can significantly attenuate the external incentives.",signatures:"Lihua Yang, Haipeng Zhang, Hailong Jiang, Shuyong Liu, Haiping Wu, Haifeng Li and Ehsan Noroozinejad Farsangi",downloadPdfUrl:"/chapter/pdf-download/67649",previewPdfUrl:"/chapter/pdf-preview/67649",authors:[{id:"288526",title:"Ph.D.",name:"Lihua",surname:"Yang",slug:"lihua-yang",fullName:"Lihua Yang"},{id:"288883",title:"Prof.",name:"Haipeng",surname:"Zhang",slug:"haipeng-zhang",fullName:"Haipeng Zhang"},{id:"288884",title:"Prof.",name:"Shuyong",surname:"Liu",slug:"shuyong-liu",fullName:"Shuyong Liu"},{id:"288885",title:"Dr.",name:"Haifeng",surname:"Li",slug:"haifeng-li",fullName:"Haifeng Li"},{id:"299788",title:"Prof.",name:"Hailong",surname:"Jiang",slug:"hailong-jiang",fullName:"Hailong Jiang"},{id:"299799",title:"Dr.",name:"Haiping",surname:"Wu",slug:"haiping-wu",fullName:"Haiping Wu"}],corrections:null},{id:"67498",title:"Ultrasonic Vibration-Assisted Hot Glass Embossing Process",doi:"10.5772/intechopen.86546",slug:"ultrasonic-vibration-assisted-hot-glass-embossing-process",totalDownloads:985,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter is intended to provide the reader with background information about the assistance of ultrasonic vibration in hot glass embossing process. For this purpose, the description of the conventional hot glass embossing process and the ultrasonic vibration-assisted hot glass embossing process will be defined first. Based on the comparison between these two processes, components of the ultrasonic vibration device which produces ultrasonic vibration will be discussed in principle. Among these components, ultrasonic horn will be especially analyzed. After that, each interesting effect of ultrasonic vibration on hot glass embossing process will be explained in detail. With the development and application of simulation tools on forming process, this chapter will finally describe some results of finite element analysis (FEA) of ultrasonic vibration-assisted hot glass embossing process.",signatures:"Lanphuong Nguyen",downloadPdfUrl:"/chapter/pdf-download/67498",previewPdfUrl:"/chapter/pdf-preview/67498",authors:[{id:"290694",title:"Dr.",name:"Lanphuong",surname:"Nguyen",slug:"lanphuong-nguyen",fullName:"Lanphuong Nguyen"}],corrections:null},{id:"66697",title:"mDFA Detects Abnormality: From Heartbeat to Material Vibration",doi:"10.5772/intechopen.85798",slug:"mdfa-detects-abnormality-from-heartbeat-to-material-vibration",totalDownloads:899,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Modified detrended fluctuation analysis (mDFA) is a novel method to check abnormality of heartbeat which is developed recently by the author. mDFA can characterize any oscillation such as heartbeat by the scaling exponent (scaling index, SI). Healthy heartbeat shows SI = 1. Dying heart’s SI sifts toward 0.5. Ischemic sick heart experimentally showed an SI way over 1.0 approaching 1.5. Random vibration, such as FM-radio noise and idling car-engine, shows SI = 0.5. Quietly running motor generates an SI almost equal to zero. Using mDFA, it is possible to check potential risk based on SI values. This chapter shows empirical results quantifying various signals from heartbeat to material vibration.",signatures:"Toru Yazawa and Shinji Omata",downloadPdfUrl:"/chapter/pdf-download/66697",previewPdfUrl:"/chapter/pdf-preview/66697",authors:[{id:"13822",title:"Dr.",name:"Toru",surname:"Yazawa",slug:"toru-yazawa",fullName:"Toru Yazawa"},{id:"298188",title:"Mr.",name:"Shinji",surname:"Omata",slug:"shinji-omata",fullName:"Shinji Omata"}],corrections:null},{id:"66894",title:"Countermeasure for High Level Sound Generated from Boiler Tube Bank Duct",doi:"10.5772/intechopen.86039",slug:"countermeasure-for-high-level-sound-generated-from-boiler-tube-bank-duct",totalDownloads:883,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Heat exchangers and boilers are widely used in various plants such as power plants and chemical plants. In the heat exchanger and the boiler, a high level sound is sometimes generated from the tube bank installed in a duct. In tube banks, warm gas flows outside of the tube, and due to the external flow around tube banks, the Karman vortex shedding occurs. At a certain frequency of the Karman vortex shedding that depends on the flow velocity, the resonance phenomenon called the self-sustained tone occurs. The self-sustained tone might cause noise problems in the surroundings, losses due to plant shutdown, etc. For suppression of the self-sustained tone, insertion of baffle plates in the tube bank is generally used. Although the insertion of baffle plates has been adopted for a long time, it is difficult to decide the effective insertion positions. On the other hand, a method using perforated plates has been proposed for the suppression of the self-sustained tones. In this chapter, we review the generation mechanism of the self-sustained tone clarified experimentally and numerically, and the methods for suppressing a self-sustained tone using baffle plates and perforated plates.",signatures:"Masaaki Mori and Kunihiko Ishihara",downloadPdfUrl:"/chapter/pdf-download/66894",previewPdfUrl:"/chapter/pdf-preview/66894",authors:[{id:"290435",title:"Ph.D.",name:"Masaaki",surname:"Mori",slug:"masaaki-mori",fullName:"Masaaki Mori"},{id:"290632",title:"Prof.",name:"Kunihiko",surname:"Ishihara",slug:"kunihiko-ishihara",fullName:"Kunihiko Ishihara"}],corrections:null},{id:"66338",title:"Effective Low Frequency Noise Insulation Adopting Active Damping Approaches",doi:"10.5772/intechopen.85427",slug:"effective-low-frequency-noise-insulation-adopting-active-damping-approaches",totalDownloads:808,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, effective low frequency noise insulation adopting active damping approaches are illustrated. In general, engineering plate structures suffer insufficient noise insulation performance in the low frequency band. To improve the structure’s noise insulation performance, active damping methods can be utilized, which aim to suppress plate structure’s efficient sound radiation modes. The collocated sensor/actuator configuration guarantees the control system’s robustness, and simplifies the control law design. In the presented study, two control laws are proposed to add active damping to the structure. One control law is negative acceleration feedback (NAF) control and the other control law is filtered velocity feedback (FVF) control. The NAF control is suitable to control one specific mode and the FVF control is suitable to realize wide band vibration control. With respect to practical implementation, a carbon fiber reinforced plastic (CFRP) plate is served as the control target and active control laws are implemented on it. Experimental system for active control is presented in detail, and some practical advises are given to help readers to solve similar problems in a convenient way. The measured sound pressure and vibration results show effectiveness of the active damping treatment.",signatures:"Ming Yuan and Fan Yang",downloadPdfUrl:"/chapter/pdf-download/66338",previewPdfUrl:"/chapter/pdf-preview/66338",authors:[{id:"290032",title:"Dr.",name:"Ming",surname:"Yuan",slug:"ming-yuan",fullName:"Ming Yuan"},{id:"290847",title:"Dr.",name:"Fan",surname:"Yang",slug:"fan-yang",fullName:"Fan Yang"}],corrections:null},{id:"66196",title:"Analysis of Energy Relations between Noise and Vibration Produced by a Low-Field MRI Device",doi:"10.5772/intechopen.85275",slug:"analysis-of-energy-relations-between-noise-and-vibration-produced-by-a-low-field-mri-device",totalDownloads:846,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Magnetic resonance imaging (MRI) tomography is often used for noninvasive scanning of various parts of a human body without undesirable effects present in X-ray computed tomography. In MRI devices, slices of a tested subject are selected in 3D coordinates by a system of gradient coils. The current flowing through these coils changes rapidly, which results in mechanical vibration. This vibration is significant also in the equipment working with a low magnetic field, and it causes image blurring of thin layer samples and acoustic noise significantly degrading a speech signal recorded simultaneously during MR scanning of the vocal tract. There are always negative physiological and psychological effects on a person exposed to vibration and acoustic noise. In order to minimize these negative impacts depending on intensity and time duration of exposition, we mapped relationship between energy of vibration and noise signals measured in the MRI scanning area and its vicinity.",signatures:"Jiří Přibil, Anna Přibilová and Ivan Frollo",downloadPdfUrl:"/chapter/pdf-download/66196",previewPdfUrl:"/chapter/pdf-preview/66196",authors:[{id:"34650",title:"Dr.",name:"Anna",surname:"Pribilova",slug:"anna-pribilova",fullName:"Anna Pribilova"},{id:"180699",title:"Dr.",name:"Jiri",surname:"Pribil",slug:"jiri-pribil",fullName:"Jiri Pribil"},{id:"180785",title:"Prof.",name:"Ivan",surname:"Frollo",slug:"ivan-frollo",fullName:"Ivan Frollo"}],corrections:null},{id:"66490",title:"Vibration Analysis and Control in the Rail Car System Using PID Controls",doi:"10.5772/intechopen.85654",slug:"vibration-analysis-and-control-in-the-rail-car-system-using-pid-controls",totalDownloads:1002,totalCrossrefCites:1,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The PID classic control systems are often employed for rail car systems to reduce the vibrations and disturbance rate during movement. In this study, the dynamic modeling and simulation of PID controls for rail car systems were carried out. Using 9 degrees of freedom, the modeling process comprises the representation of the rail car system and the rail track followed by the generation of equations of motion as well as differential equations for the rail car body, wheel sets and bogie. The represented systems are simulated in the MATLAB Simulink 2018 environment based on the equations of motion generated, and subsequently vibration analysis was carried out. The PID control system tuned according to the Nichols-Ziegler rule was introduced to minimize the vibrations and disturbance rate. The performance of the control and the rail car system in terms of the input step response, bandwidth, frequency, phase margin, frequency and input and output rejections was evaluated. The control system demonstrated significant robustness in providing the required active control for the system, while there was improved stability and reduction in noise and vibration under control action of the PID, thus improving ride comfort.",signatures:"Ilesanmi Afolabi Daniyan and Khumbulani Mpofu",downloadPdfUrl:"/chapter/pdf-download/66490",previewPdfUrl:"/chapter/pdf-preview/66490",authors:[{id:"11921",title:"Prof.",name:"Khumbulani",surname:"Mpofu",slug:"khumbulani-mpofu",fullName:"Khumbulani Mpofu"},{id:"260269",title:"Dr.",name:"Ilesanmi Afolabi",surname:"Daniyan",slug:"ilesanmi-afolabi-daniyan",fullName:"Ilesanmi Afolabi Daniyan"}],corrections:null},{id:"66567",title:"Analysing Non-Linear Flutter Vibrations Using System Dynamic Approach",doi:"10.5772/intechopen.85426",slug:"analysing-non-linear-flutter-vibrations-using-system-dynamic-approach",totalDownloads:762,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The objective of this work is to investigate the dynamic behaviour of aero-elastic vibrations in the presence of non-linear stiffness such as free-play mechanism, softening or hardening stiffness. A closed loop dynamic system is proposed to represent the phenomenon of flow-structure interaction. In this approach a transfer function for generating the aerodynamic forces based on the structural response is constructed in the feedback loop of the dynamic system with the aid of Padé rational function. The effects of the non-linear factors therefore can be included conveniently in time domain simulation and the stability of limit cycle oscillations (LCO) can be analysed accurately.",signatures:"Cosmas Pandit Pagwiwoko and Louis Jezequel",downloadPdfUrl:"/chapter/pdf-download/66567",previewPdfUrl:"/chapter/pdf-preview/66567",authors:[{id:"56035",title:"Prof.",name:"Louis",surname:"Jézéquel",slug:"louis-jezequel",fullName:"Louis Jézéquel"},{id:"289639",title:"Associate Prof.",name:"Cosmas",surname:"Pagwiwoko",slug:"cosmas-pagwiwoko",fullName:"Cosmas Pagwiwoko"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7712",title:"Natural Hazards",subtitle:"Impacts, Adjustments and Resilience",isOpenForSubmission:!1,hash:"279dba9ff08f763c747d1976a17c8ea4",slug:"natural-hazards-impacts-adjustments-and-resilience",bookSignature:"Ehsan Noroozinejad Farsangi",coverURL:"https://cdn.intechopen.com/books/images_new/7712.jpg",editedByType:"Edited by",editors:[{id:"70678",title:"Dr.",name:"Ehsan",surname:"Noroozinejad Farsangi",slug:"ehsan-noroozinejad-farsangi",fullName:"Ehsan Noroozinejad Farsangi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7364",title:"Acoustics of Materials",subtitle:null,isOpenForSubmission:!1,hash:"2f32f18842d53727b0587800fa159a44",slug:"acoustics-of-materials",bookSignature:"Zine El Abiddine Fellah and Erick Ogam",coverURL:"https://cdn.intechopen.com/books/images_new/7364.jpg",editedByType:"Edited by",editors:[{id:"143693",title:"Dr.",name:"Zine El Abiddine",surname:"Fellah",slug:"zine-el-abiddine-fellah",fullName:"Zine El Abiddine Fellah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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by"}}]},chapter:{item:{type:"chapter",id:"72987",title:"Actinobacteria: Potential Candidate as Plant Growth Promoters",doi:"10.5772/intechopen.93272",slug:"actinobacteria-potential-candidate-as-plant-growth-promoters",body:'Plant growth-promoting (PGP) microbes (epiphytic, endophytic, and rhizospheric) are likely to enhance the growth and productivity of crop by increasing the nutrient content. These plant microbiomes have been sorted out from diverse sources belonging to all three domains: archaea, bacteria, and fungi. The microbes associated with the plant rhizosphere are termed as rhizospheric microbes, and among them, actinobacteria are most dominant in nature [1]. As many researches stated actinobacteria as major microbial population present in the soil. The actinobacteria are known to have high G-C (57–75%) contents and comprise a broad group of filamentous, spore-forming, gram-positive, and aerobic bacteria that form branching filaments or hyphae and play a fundamental function in ecology along with soil nutrient cycle. Actinobacteria resemble to unicellular bacteria, they are different by not having distinct cell wall; instead they produce mycelium, a nonseptate and more slender [2]. Actinobacteria are widely dispersed in both terrestrial ecosystem, as present in soil, and aquatic ecosystems as in fresh and marine water. The terrestrial actinobacteria contribute in recycling process and are essential to the decomposition of many complex mixtures of polymers and organic material, located in dead plants, animals, and fungal materials. The phylum actinobacteria is currently recognized as the largest taxonomic units within the bacterial domain and recognized for its economic importance because it produces various biological active substances like vitamins, antibiotics, and enzymes. It is estimated that almost 23,000 bioactive secondary metabolites are produced by many microorganisms and almost 45% (10,000 out of 23,000) of these bioactive microbial metabolites are produced by actinomycetes. Among these actinomycetes,
Actinobacteria | Host plant | Target pathogen | References |
---|---|---|---|
[5] | |||
[6] | |||
Medicinal plants | [7] | ||
[8] | |||
[9] | |||
[10] | |||
[11] | |||
[12] | |||
Leguminous plants | [13] | ||
[14] | |||
[15] | |||
[16] | |||
[17] |
Biological activities of some isolated actinobacteria.
Plant growth and development of important organs in plant are facilitated by plant hormones called plant growth regulators (PGR). These PGR can influence plant growth even at very low concentration. Actinobacteria act as PGPR, and its impact is determined by considering the effectiveness and ability to influence PGR in root system. Different mechanisms used for promoting PGR by actinobacteria are classified into direct and indirect method (Figure 1).
Mode of action of actinobacteria.
The direct method exhibits various activities including solubilization of phosphorus, nitrogen fixation, iron acquisition, and production of different phytohormones, for instance, indole acetic acid (IAA), cytokinins, and gibberellins. In indirect method, actinobacteria promote plant growth in many ways such as synthesizing extracellular enzymes for fungal cell wall degradation producing antibiotics, volatile compounds (VOCs), inducting systemic resistance, as well as competition for nutrients [18].
Actinobacteria promote the growth of plants by involving in various direct activities as shown in Table 2.
Actinobacteria | PGP traits | Host plant | Reference |
---|---|---|---|
Siderophore production | Rice ( | [19] | |
IAA production Phosphate solubilization | Wheat | [20] | |
Nitrogen fixation | Soybean ( | [21] | |
IAA production | Mandarin ( | [22] | |
IAA production | Sorghum Rice | [23] | |
ACC deaminase activity | Pepper ( | [24] | |
Phosphate solubilization | Carrot ( | [25] | |
Nutrient uptake | Clover | [26] | |
Gibberellic acid, IAA, | Marine environments | [27] | |
Auxin, gibberellin, and cytokinin synthesis | Wheat | [28] | |
Nitrogen fixation IAA production ACC deaminase activity | Canola | [29] | |
Phosphate solubilization | — | [30] | |
Actinobacteria | Phosphate solubilization, Nitrogen fixation | Soya bean | [31] |
Direct plant growth-promoting (PGP) properties of actinobacteria.
Nitrogen is a well-known and key element of nucleic acids and proteins, and it is also an indispensable nutrient for plant growth. Nitrogen gas is abundantly found in the air, constituting 78% of the atmosphere, but it is not directly available to plants for uptake unless it is converted into its soluble form [32]. Biological nitrogen fixer (BNF) used nitrogenase enzyme system which converts the atmospheric nitrogen required by plants into ammonium and nitrates [33]. Additionally, synthetic nitrogen fertilizers are also supplied to balance the limited availability of nitrogen provided by biological nitrogen fixer. But these fertilizers might be harmful to health and agricultural sustainability. Therefore, actinobacteria are good choice to be utilized as BNF to improve the plant growth for sustainable agriculture.
After nitrogen, the second major element, for plant growth, is phosphorus [36]. Phosphorus exists in soil as both inorganic and organic forms [37], but 0.1% phosphorus is available as soluble form to be absorbed by plants. An immediate need of phosphorus is fulfilled by chemical fertilizers, like nitrogen, but the majority of these applied chemical fertilizers are not only expensive but also wasted because it retains in soil as an insoluble form just after the application [37]. In the past decades, many microbes have been described which can solubilize the insoluble phosphorus, and since then, numerous studies by many researchers have been carried out to investigate the phosphate-solubilizing potential of different microbes such as bacteria, fungi, and actinobacteria [38]. Different in vitro and in vivo studies have been executed, which highlight capability to solubilize soil phosphorus by PGP actinobacteria, for instance,
Plant disease suppressing trait adopted by actinobacteria.
Iron is an essential nutrient element for all organisms, which acts as a necessary co-factor for several enzymatic reactions. Many beneficial actinobacteria including
Several rhizospheric and endophytic actinobacteria have been noticed to yield several phytohormones, namely, indole acetic acid (IAA), cytokinins, and gibberellins. These phytohormones show a significant role in the plant growth [47]. The most important phytohormone is indole-3-acetic acid, a principal form of auxin that shows the useful impact on plants by various cellular processes like cell division, elongation, and differentiation. Recently, endophytic actinobacteria are getting more attention because of their role in the production of phytohormones. It has been reported that
In indirect plant growth mechanism, actinobacteria also enhance the growth of plants like direct mechanism which is mentioned in Figure 3.
Alleviation of abiotic stress in actinobacteria.
Actinobacteria synthesize many different extracellular enzymes that help to decompose material in soil. Some of these enzymes include xylanases, chitinases, hemicellulose, nucleases, amylases, lipases, glucanases, pectinase, proteinases, cellulases, ligninases, and keratinase. Mainly soil-living actinobacteria are saprophytic and play a central role in decomposition. Actinobacteria use this mixture of enzymes for decomposition against a variety of phytopathogens and majorly contribute to biocontrol potential by damaging cell wall of these pathogens. Cell wall of many bacteria and fungi is made up of polymers like glycan, cellulose, chitin, protein, and lipids [49]. Actinobacteria are regarded as the dominant organisms that decompose chitin in soil and also considered as promising antagonistic agents for biocontrol because of the hydrolytic reaction on mycelium of the fungi. Acctinobacteria are also observed to produced chitinase enzyme that inhibit fungal growth by cell wall chitin hydrolysis. Many species of
Enzymes | Actinobacteria | References |
---|---|---|
Chitinase | [52] | |
Chitinase, glucanase | [53] | |
Cellulose | [54] | |
Ligase | [25] | |
Amylases, lipases, β-1-3-glucanase | [55] | |
Chitinase, glucanase and protease | [56] |
Production of hydrolytic enzymes by actinobacteria.
As PGP, actinobacteria also act to raise the soil fertility by exhibiting various activities; hence, it is acknowledged as a main natural nutrient enhancer. Besides siderophore producer and phosphate solubilizer, actinobacteria also produce many kinds of enzymes like lipase, amylase, peroxidase, xylanase, chitinase, keratinase, pectinase, cellulase, and protease. This cocktail of enzymes helps to convert nutrients into simple mineral forms, and due to this nutrient cycling ability of actinobacteria, it is considered as an optimal candidate for natural fertilizers [38]. These actinobacteria also promote the soil metal-mobilizing ability like Fe, Zn, and Se, which ultimately increase the germination of seeds and plant growth. Current research has exposed that the root colonization of arbuscular mycorrhizal fungi increases growth of crop and zinc and iron content of chickpea grains [57]. Under greenhouse and field conditions, two PGPR, namely,
Anthropogenic activities are the main cause of metal pollution of agricultural lands which led to a decrease in the fruitful agricultural cropland. As reported by the Environmental Protection Agency (EPA), nearly more than 40,000 contaminated sites are present in the United States. Furthermore, due to heavy metal contamination, 50,000 hectare of forest, 55,000 hectare of pasture, and 100,000 hectare of cropland have vanished, and these need retrieval process [60]. PGP like actinobacteria stay in metal-contaminated soil and increase the bioremediation process by extracting and solubilizing mineral. Different reactions like oxidation, metal reduction, and biosorption as well as several substances like organic acids, siderophores, polymeric substances, glycoprotein, and bio-surfactants are released by the microbes which aid in the metal-mobilizing property of these microbes. Many studies have been performed by researchers which demonstrated the metal-mobilizing mechanism [61].
Primarily, plants use beneficial microorganisms and plant integrated defense mechanism to protect themselves from phytopathogens [62]. Beneficial microorganisms (pathogen antagonistic) alleviate the pathogen stress in plants through different mechanisms like secretion of anti-pathogenic metabolites, competition for space, and nutrients [8]. Actinobacteria also play vital role in plant protection against plant pathogens utilizing nutrients, required by pathogens for growth. Meanwhile, actinobacteria produce different volatile compounds, antibiotics and cell wall degrading enzymes against phytopathogens [63]. Actinobacteria have been reported to produce various antifungal volatile organic compounds against fungal disease [64].
Endophytic actinobacteria | Host plant | Metabolite | Target pathogen(s) | Reference |
---|---|---|---|---|
Munumbicins A, B, C and D | [70] | |||
Potato | Geldanamycin | [71] | ||
Rice | 2,3-Dihydroxybenzoic acid, phenylacetic acid, cervinomycin A1 and A2 | [72] | ||
Wheat | Malayamycin | [73] | ||
Pepper | 2-Furancarboxaldehyde | [74] | ||
Saadamycin/5,7-Dimethoxy-4-pmethoxylphenyl coumarin | [75] | |||
Coronamycin | [76] | |||
Coumarin | [77] | |||
Ketoconazole, fluconazole, miconazole | [78] | |||
100% | Tomato | Filipin III (purified antibiotic) | [79] | |
Banana | [80] | |||
Rice | Bonactin | [81] | ||
Benzaldehyde, butanoic acid | [53] |
Metabolites produced by actinobacteria used to suppress disease.
Several abiotic stress factors including flooding, extreme temperatures, salinity, nutrient stress, drought, and metal stress impose a harmful impact on yields of the crop, as well as it also severally damaged the soil. As described by the Food and Agriculture Organization (FAO), if precautionary steps are not implemented, in the next 25 years 30% land degradation will happen due to abiotic stress factors, and this will rise to 50% in 2050 [16]. Strains of actinobacteria have better tolerance against abiotic stress factors like temperature, salinity, and metal stress, and inoculation of tolerant actinobacteria strain was noticed to encourage the plant growth. Useful effects of PGP
Production of food to fulfill the need of an increasing population and mimic the reliance on nonrenewable resources and also environmental effect is the greatest challenge of this century. To complete this challenge, the use of plant growth microbes such as actinobacteria is a good choice as an alternative tool for sustainable agriculture. Various studies highlight the abilities of actinobacteria as a plant growth promoter and their additive impact on plant growth and protection. Actinobacteria isolates have shown the multidimensional way to be effective on plant growth. They promote plant growth by involving various activities like production of phytohormones, siderophore production, solubilization of phosphate, fixation of nitrogen, complementing mycorrhizal fungi, and also balancing the ecology of the soil system. Additionally, many studies also have proven the potential of actinobacteria as a biocontrol agent. These characteristics of the actinobacteria group have proved them as inevitable tools for increasing productivity and quality in agriculture. Keeping in mind all these aspects, it is a need of time that we focus on the use of actinobacteria as an alternative tool and reduce the use of harmful chemicals. The studies referred in this chapter also support the belief that the use of eco-friendly microorganisms and designing new formulations with cooperative microbe might contribute to plant growth improvement.
Effective supply chain management is now recognized as a key element of competitiveness and success in most industrial enterprises. However, since the network that makes up the supply chain is usually too complex to analyze and optimize on a large scale, it is often preferable to focus on smaller parts of the system so as to gain a full understanding of its characteristics and performance. Each component of the same level manages its stock in a independent to each other. Such attention is paid to this network because of its complexity (uncertainty of demand, lead time, etc.) which increases significantly. The overall performance of the storage network, whether evaluated in economic terms or in terms of customer service, can be significantly improved if sites (retailers, outlets, stores) work together in this random environment. Collaboration between sites is defined as cooperation where collaborating sites share their stocks when needed. Generally, the collaboration is made laterally (in the same echelon) from a site which has a surplus of stock to another which faces a shortage of stock: what is called lateral transshipment. Collaboration could be an effective way to improve the logistics performance of the company without any need for additional cost. As the cost of lateral transfer of items between sites is generally much lower than the cost of shortage and the cost of emergency delivery from central warehouse, and the lateral transfer time is shorter than the regular replenishment lead time, so the collaboration could reduce the total system cost and improve the level of service for customers. There are two types of collaboration: emergency collaboration and preventive collaboration. The goal of the emergency collaboration, which takes place after receipt of the demand, is to address current disruptions in inventory. While preventive collaboration, which is done before receiving customer demand, aims to reduce the risk of having stock-out in the future. Collaboration can also be classified according to the quantity to be transferred: there is full collaboration where the site offers all its available stock when another site faces a stock-out and partial collaboration where the site keeps part of the stock to cover future demand.
Several quantitative decision support models are proposed in the literature to study the impact of lateral transfer between sites. These models can be classified according to several characteristics: (1) the structure of the network (2) the type of optimization model.
In the articles reviewed [Shahab Derhami et al. [1], Wong et al. [2]], there are at least six important criteria which are taken into consideration in a comprehensive study of the subject: (1) the number of collaborators in the group, (2) the time of replenishment from the central warehouse, (3) the profile of the request, (4) the time (before or after receipt of the request) and the purpose of the collaboration (emergency or preventive), (5) repairability of stored items and (6) performance measures (cost or level of service).
A large number of works focus in their research on the type of lateral transshipment, ie. Emergency transhipment or preventive transhipment.
Herer et al. [3] analyzed the emergency lateral transshipment strategy between two-retailers and found this last can simultaneously improve lightness and agility. Paterson et al. [4] and Noham and Tzur [5] respectively developed a quasi-myopic approach and a simple heuristic algorithm. Van et al. [6] have presented models where preventive collaboration takes place before receipt of the request in order to have a better distribution of stock available between the different collaborators.
Archibald et al. [7] studied an inventory system considering that basic stock is ordered, while the decision to place an emergency order from the warehouse or to use lateral transfer depends on the costs, the time remaining in the warehouse. The period and inventory available in the alternative site. Relaxing the hypothesis of the instant central warehouse replenishment time considerably complicates the mathematical analysis of the network because of the interrelationships between demand, quantities to be transferred and stock in transit. In particular, if the optimal transfer strategy should take into account both on-hand and on-order inventory, implying that state space should be increased. In addition, full collaboration assuming that the lead time is negligible and where the costs across the sites are the same, is not necessarily optimal when the lead time is positive. Therefore, the decision space is more complex and the exact model becomes intractable even in the simple case (two-retailers). Li et al. [8] aim to study the effect of preventive lateral transhipment on the quantities ordered in a two-echelons inventory system. Liao et al. [9] studied a comparison between side transfer and emergency order options. The sharing is done in a bidirectional way to coordinate the transhipment quantities. Olsson [10] studied a lateral transshipment policy for a two-retailers inventory system with a positive transshipment delay. A more sophisticated transhipment policy has been developed, the results of which show that it is worthwhile to reduce transhipment times. Torabi et al. [11] analyzed a problem of an inventory system in an e-commerce environment with complete-pooling. A mixed integer programming model has been formulated and solved to minimize logistics costs. Lee and Park [12] studied an inventory model with two retailers and a single supplier with uncertain capacity. By applying lateral transshipment, they found that a transshipment price may be able to coordinate the supply chain. Feng et al. [13] discussed a dynamic problem of preventive lateral transshipment in a centralized inventory system based on Markov decision making. They used simulation to study the inventory system with significant reorder time and different costs. The authors conclude that full collaboration is less expensive than partial collaboration. They also provided approximations for on-hand inventory, shortage inventory, and transfer inventory as well as heuristics to determine a near-optimal reorder point solution under full collaboration. Silbermayr et al. [14] investigated the problem of emergency lateral transshipment with environmental sustainability. The research of Nakandala et al. [15] focuses on the study of an emergency lateral transshipment model for perishable products in a fresh produce supply chain. This research is concerned with applying a more comprehensive transshipment decision method to help the practitioner make profitable decisions. Timajchi et al. [16] discussed an inventory flow problem with a transshipment of pharmaceutical items. Feng et al. [17] analyzed such advanced research to study emergency lateral transshipment and preventive transshipment in a comparable partially delayed setting. Dehghani and Abbasi [18] propose a policy of emergency transshipment of perishable foodstuffs in supply chains. They developed a heuristic solution to calculate performance metrics. Timajchi et al. [19] analyzed deterioration in pharmaceuticals and proposed a side-shift option to meet demand while simultaneously minimizing costs and accidental losses. Yi et al. [20] found the optimal emergency transshipment and replenishment decisions within a decentralized inventory system framework. They build a multistep stochastic model that captures the uncertainty of demand and changing customer behavior.
We have studied the periodic storage policy (R, Si) for each retailer
According to this policy, at the end of each review period R (assumed equal to 28 days, according to, Emel and Lena [21], if the stock position of retailer
We are targeting to improve the global profitability of stock system composed of two retailers by minimizing the Desservice rate of each site by decreasing the quantity out of stock. This result in the improvement of the Average Global Profit in the whole inventory system this can be done by applying the cooperation between these retailers which is called by the transshipment, either by the application of the policy of transhipment: “Complete-Pooling” or “Partial-Pooling”. Each time we modified the threshold of the “Partial-Pooling” transshipment policy, the periodicity
To solve this type of problem, we can apply the “Without-Transshipment” policy, that is to say, when the retailer falls into an out-of-stock position, he demands the quantity of central deposit missing to satisfy customer demand, or, by applying the “With-Transshipment” policy, by adopting a relationship between the retailers who are in the same line to minimize the stock shortage and meet a random demand. In this chapter we will try to find the most appealing controversy that aims to maximize the expected Average Global Profit and minimize as much as possible the Average Global Desservice Rate.
The quantity of supply within time intervals
The demand
When this demand causes a stock out during the period of the check at the retailer
There remain two main constraints in this part of this research work, for the two sites 1 and 2. They are defined as follows:
The stock balance constraint
If
If
If
If
If
If
From these constraints, we can see that, if the two retailers have excess stocks, then no product transshipment will take place between these depots (
Likewise if the two warehouses face a shortage of stock then there will be no collaboration between them (
But, when depot 1 has a surplus (
Likewise, when site 2 has excess stock (
The notations used in this chapter are as follows:
The resolution of our problem is fundamentally based on the probabilistic behavior of customer demands. It is a continuous distribution which follows the normal law.
For this, among the sampling techniques that allow an exploration of customer demand, we selected the simulation. Its principle is then to select, for each demand, random values determined according to an average and a standard deviation. In addition, the demand is generated independently time and between retailers.
We will then, model in this chapter, Two-Retail Stock Distribution System, successively appointed “Without-Transshipment” and “With-Transshipment”. The latter, may be in the form of a transshipment policy called “Complete-Pooling “, if the retailer agrees to transfer all of its available stock if necessary, or by “Partial-Pooling”, if the transshipment is carried out by preserving a targeted stock level, by modifying the threshold beyond which the retailer agrees to apply transshipment for each experience. First, the latter will be set at a value which is equal to two times the demand (this is that is to say, to protect the next two demand), then it will be equal, to the next demand and finally it is worth to a safety stock which equals 30% of stock position.
In this case, if the retailer is confronted with a random demand and to satisfy it and does not fall out of stock, he must demand the missing quantity from the central deposit.
This can be represented by Figure 1.
Two-retailer stock distribution system “without-transshipment”.
For the Without-Transshipment (
The simulation model supply chain: no-pooling.
To properly model this stock system using the Arena software, it is necessary to list the assumptions and the mode of operation retained in this work:
The storage capacity of the central warehouse is infinite;
Retailer
Partial satisfaction of an order is not allowed,
Any unsatisfied order will be lost;
Only one order (emergency according to the central depot) is allowed per supply cycle (at the end of period R); with
There is no definite order of priority. All customer orders are managed according to the same FCFS (First Coming First Served) priority rule;
The distribution center has sufficient storage capacity, so as not to introduce availability constraints (Unlimited storage policy);
At the start of each supply cycle, a size order
The Average Global Profit function of our centralized inventory system for two “Without-Transshipment” retailers contains the selling price of the customer product and the cost of the shortage.
It takes the general form of the Eq. 2.
If one of the two retailers is in the out-of-stock position, then cooperation can be established between them to meet their random demand. This collaboration usually takes the form of “Transshipment-Lateral”, also quite simply known as “Transshipment” (Figure 3), which allows stocks to be pooled to alleviate the uncertainties relating to demands arriving at sites of the same level.
Two-retail stock distribution system “with-transshipment”.
In this section, we will study two transshipment policies successively named “Complete-Pooling” and “Partial-Pooling”.
For the first transshipment policy called “Complete-Pooling” the modeling by the ARENA 16.0 software can be presented in Figure 4.
The simulation model supply chain: complete-pooling.
We consider the following assumptions:
Retailer 1 confronts a random demand independent of demands from retailer 2;
The transshipment time is zero;
In the case where a retailer 1 faces a stock shortage, whereas, the retailer 2 has a surplus of inventory, a transshipment of the necessary quantity
In the event of “Complete-Pooling”, the retailer who is in the overstock position agrees to transfer all of his available stock if necessary.
The function of Average Global Profit for our centralized system composed of two levels and two retailers, by integrating transshipment and applying the “Complete-Pooling” policy, can be formulated by the Eq. 3.
With
We assume that retailer 1 is the one facing a stock shortage, so according to this transshipment policy, retailer 2 agrees to transfer all of its available stock if necessary, even if this stock is not enough to fill any the demand of the client who is at the origin of the demand for the transshipment. The quantity of the transshipment, according to this policy, will be formulated in the form of the Eq. (4).
The objective is to identify the most economically profitable transshipment policy for a centralized system over a finite time horizon R, by seeking the lowest possible Average Global Desservice Rate.
For this, the objective function of the “Complete-Pooling” transshipment policy will be defined in the form of the Eq. (5).
S/C
With
And
For the second transshipment policy called “Partial-Pooling” the modeling by the ARENA 16.0 software can be presented in Figure 5.
The simulation model supply chain: partial-pooling.
Furthermore, the hypotheses already indicated for the “Complete-Pooling” transshipment policy, we can add another specific assumption for the “Partial-Pooling” policy, that is, the lateral transfer is carried out while preserving a level of targeted stock. We find in research work the following variants:
The retailer accepts the transshipment up to the amount of surplus stock to its safety stock,
the retailer accepts the transshipment up to the amount of surplus stock at his order point,
the retailer accepts the transshipment up to the amount of surplus stock at the estimated demand for the following period (See, Archibald et al. [7]).
the decision to make a transshipment at the level of a retailer depends on the current stock level and the time remaining before the next supply.
In our chapter, we are interested in the third variant where the retailer accepts the transshipment up to the amount of surplus demand for a first proposal of the threshold value. Then we add two other personal contributions, first estimating that it will be equal to “Two multiply by demand”. Secondly, it will be equal to “30% of stock position”, to improve the Average Global Profit of the entire system made up of two retailers while minimizing as far as possible the average stock-out (Average Global Desservice Rate).
In the following sections of this chapter, we first describe the mathematical modeling of a “Without-Transshipment” stock system for a warehouse number set to two. Then we modify it, by integrating, the two policies of transshipment, named, successively, “Complete-Pooling” and “Partial-Pooling”.
The function of the average global profit apply the transshipment policy “Partial-Pooling”, requires the integration of the quantity lost for each retailer after the accumulation of stock.
The average global profit function will be formulated by the Eq. (6).
With
And
To significantly improve a purely reactive transshipment policy, it would be possible to combine it with another proactive policy; this will be named by “Hybrid transshipment policy”.
In this area of research, the policy of transshipment “Partial-Pooling”, to put the action on the importance of the estimate of the future to minimize as soon as possible the quantity not satisfied which governs positively on the economic profitability.
We estimate that retailer 1 is facing an actual stock shortage, therefore, the amount of lateral transfer from retailer 2 to 1 to minimize or avoid this lost quantity, according to this transshipment policy will be carried out while preserving a targeted stock level. Named the transshipment threshold and it will be formulated by three equations according to the fixing of the latter.
First of all, we estimate that it will be worth to Twice multiply by the Demand, for this, the quantity of transshipment from 2 to 1 will be formulated by the Eq. (7).
Then we assume that this threshold is equal to the Next Demand, and then the amount of lateral transfer from 2 to 1 will be formulated by the Eq. (8).
Finally, we propose that it be equal to a safety stock which is worth 30% of
For the second transshipment policy (“Partial-Pooling”), the objective function will be defined in the form of the Eq. (10).
With
And
And
With
With
And
We recall that, according to Meissner and Rusyaeva [22], the initial level of replenishment for a demand that follows the normal law of mean and standard deviation, will take the form of the equation and will be calculated by applying the Eq. 11.
With:
Table 1 shows the different measures of initial stock level of replication and for n = 2, with N: number of retailers.
Recall that the network structure considered in this chapter is made up of a distribution center and two retailers, who face random and non-identical demands on average and standard deviation. We assume that the simulation length is 10 years.
We have assumed that the demand
Also, we have considered in all the examples of our research that:
The revision period R = 28 days, (Based on Emel and Lena, [21]);
The unit sale price for retailer 1 equal to 95 $ and that of retailer 2 is worth 125 $,
The unit cost of rupture whatever the site is equal to 30 $,
The unit cost of transshipment =3 $, 0.5 $, k = 2, 3, 4,…, 10.
We led to the resolution of our problem via simulation by successively testing the “Without transshipment” and “With-transshipment” policies. We then give the following performance measures, for the evaluation of the contribution to perform the Pooling between the retailers:
The number of supply orders (without transshipment),
The number of orders received with the transshipment application,
The amount of lateral transfer from a warehouse which is in overstock position to that of the same level which is in rupture position,
The quantity of order not fulfilled at a retailer (quantity lost),
Average Global Profit at a retailer,
The Average Desservice Rate (the rate of customer dissatisfaction after the transshipment).
In Table 1 we present the different measures of the initial stock level of the replenishment.
We examine the effect of three input parameters on the benefits of transshipment, namely:
The periodicity “T”,
The unit cost of transshipment,
And, the threshold of the “Partial-Pooling” transshipment policy.
The numbers calculated in Table 1 reveal the considerable effect of collaboration between the sites in terms of Average Global Profit.
Likewise, they present the results of the performance evaluation of the “Complete-Pooling” and “Partial-Pooling” transshipment policies compared to the “Without-Transshipment” policy. We note, first, that these results verify those already obtained by the mathematical model for a stock system with two non-identical retailers, namely that:
the comparative values obtained by simulation in Table 1, using the “ARENA” software, confirm the evidence of the advantage of the application of “transshipment” between the sites in terms of improving the Average Global Profit. For example, for k = 2, “Complete-Pooling” improved the performance of the centralized inventory system by increasing the average value of Average Profit Global of the two retailers, from 39,125 to 44,087, that is to say, a relative change worth 13%,
These values show the effect of the change in periodicity on economic profitability, by improving the Average Global Profit from k = 2 to k = 4. Whereas, the evolution of the value of the latter undergoes an imperfection beyond k = 4, and this will be explicit for k = 5 up to k = 10,
Comparative Average Global Profit Improvement Percentage Values Obtained by Simulation Using ARENA Software for the Two Transshipment Policies “Complete-Pooling” and “Partial-Pooling” are reported in Table 2.
k | ||
---|---|---|
2 | 229 | 470 |
3 | 335 | 687 |
4 | 440 | 900 |
5 | 545 | 1112 |
6 | 648 | 1322 |
7 | 753 | 1532 |
8 | 857 | 1741 |
9 | 960 | 1950 |
10 | 1063 | 2158 |
Determination of different measures of the initial level of replenishment.
K | Without-transshipment/complete-pooling | Complete-pooling/partial-pooling: | Complete-pooling/partial-pooling: | Complete-pooling/partial-pooling: |
---|---|---|---|---|
2 | 13% | 3% | 17% | 26% |
3 | 15% | 2% | 14% | 18% |
4 | 16% | 1% | 8% | 11% |
Determination of the values of the relative improvement percentage of the average global profit for a unit cost of transshipment = 3 $.
To calculate the different percentages of relative improvement in Average Global Profit indicated in Table 2, we apply the mathematical formula (12).
(This for the first column of the table while for the two transshipment policies (“Complete-Pooling” and “Partial-Pooling”) we apply this formula while looking for the percentage improvement value between them).
From Table 2, we see that, the percentage improvement in Average Global Profit, depends on the periodicity T, as well as, on the transshipment policy applied, (“Complete-Pooling” or “Partial-Pooling”).
We note that the first lateral transfer policy (“Complete-Pooling”) improves the economic profitability of the “No-transshipment” policy but with a percentage of improvement less than that of the transshipment policy (“Partial- Pooling”). Because of this, the latter is more advantageous, because the Average Global Profit of the former will be improved regardless of the threshold applied. We will conclude, too, that the modification of the latter acts on this improvement, take as an example, for k = 2, the “Partial-Pooling” with a threshold of the “Twice the Demand” target to reach a percentage of improvement Relative Average Global Profit of “Complete-Pooling” equal to 3% but with the change of the threshold to “Next Demand” this value is worth 17% and finally for a threshold equal to “SS = 30% of
This allows us to conclude that the most economically profitable transshipment policy is that of “Partial-Pooling” and especially with a lateral transfer threshold equal to “SS = 30% of
The study of the impact of the variation in the unit cost of transshipment on the Average Global Profit is carried out in cases where C = 0.5 $. The simulation results are presented in Table 3.
We examine, for a stock system composed of two levels and two non-identical retailers, the impact of the variation in the unit cost of transshipment and the threshold of the “Partial-Pooling” policy.
The results of the simulation presented in Table 3 show that a variation in this unit cost of transshipment, by reducing it from 3$ to 0.5$, acts mainly on improving the profitability of the entire centralized system between the “Without -Transshipment “and that of “With-Transshipment”, for that, we will conclude that, the coordination between the sites of the same level allows to improve the profitability of the whole system, but it reaches the most effective values by the application of the “Partial-Pooling” transshipment policy and above all with the fixing of the threshold at “security stock = 30% of PSiT”.
For this, we will first of all look for the relative improvement percentage of the Average Global Profit of the centralized system for the first “Complete-Pooling” transshipment policy by reducing this cost (see Table 4), then by calculating it with the integration of the second “Partial-Pooling” policy (see Table 5).
K | Without-transshipment | Complete-pooling | Partial-pooling | ||
---|---|---|---|---|---|
Twice the demand | Next demand | Security stock = 30% of PSiT | |||
2 | 39,125 | 45,054 | 46,938 | 52,502 | 56,400 |
3 | 65,044 | 75,754 | 77,740 | 85,952 | 88,976 |
4 | 88,000 | 102,306 | 103,510 | 110,200 | 113,800 |
5 | 86,240 | 101,200 | 102,520 | 105,035 | 107,097 |
6 | 83,600 | 97,657 | 99,125 | 101,257 | 103,356 |
7 | 80,960 | 94,230 | 95,127 | 96,102 | 98,235 |
8 | 78,320 | 91,560 | 93,276 | 94,605 | 97,203 |
9 | 70,400 | 82,359 | 83,900 | 88,007 | 90,102 |
10 | 66,000 | 77,135 | 79,230 | 84,009 | 87,990 |
Determination of the average global profit for a unit cost of transshipment = 0.5 $.
K | Percentage improvement in average global profit |
---|---|
2 | 2% |
3 | 2% |
4 | 1% |
Determination of the percentage improvement in average global profit for “complete pooling” between C = 3 $ and C = 0.5$.
k | Pourcentage du Profit Global Moyen | ||
---|---|---|---|
Twice the demand | Next demand | Security stock = 30% of PSiT | |
2 | 3% | 2% | 2% |
3 | 1% | 1% | 1% |
4 | 1% | 3% | 2% |
Determination of the percentage improvement in average global profit for partial pooling between C = 3$ and C = 0.5$.
The determination of the various relative improvement percentage values of the Average Global Profit for the “Complete-Pooling” transshipment policy or (simply noted CP) between C = 3 $ and C = 0.5 $, is done by applying the Eq. 13.
According to the Table 4, we quote for example that, for k = 3 and with a unit cost of transshipment equal to 3$, the “Complete-Pooling” transshipment policy improved the value of average overall profit “Without-Transshipment” from 65,044 to 74,538, therefore with an improvement value equal to 15%.
But, with a slight reduction in the unit cost of transshipment, this percentage becomes equal to 17%. For this, we will conclude that the unit cost of transshipment has an influence on the improvement of the Average Global Profit of the whole centralized stock system.
From Table 5, we will conclude that the application of the unit cost of transshipment equal to 1 $ is more profitable in terms of gain compared to that which is worth 2 $, and this is remarkable from the results presented in this table, but with a small percentage of improvement.
For example,
For a threshold = Twice the Demand: the “Partial-Pooling” transshipment policy with a unit cost equal to 0.5 $ makes it possible to improve the Average Global Profit of the one that equals 3 $ with a minimum value equal to 1% up to a maximum value equal to 3%.
For a threshold = Next Demand: With a unit cost of transshipment worth $ 0.5, the “Partial-Pooling” transshipment policy has improved the Average Global Profit by that which equals 3 $ with a minimum value equal to 1% up to a maximum value equal to 3%.
For a threshold = 30% of PSiT: With a unit cost of transshipment equal to 0.5$, the economic profitability of the centralized system for the policy of transshipment “Partial-Pooling” undergoes an evolution compared to that which equals 3 $ of a minimum value equal to 1% up to a maximum value equal to 2%.
In fact, according to the study of the impact of the change in the unit cost of transshipment and the threshold of the “Partial-Pooling” policy on the improvement of Average Global Profit, the analysis of the sensitivity of performance to this variation can be summarized as follows:
The decrease in the unit cost of transshipment influences the increase in the percentage of relative improvement in economic profitability.
The evolution of Average Global Profit has a strong relationship with the modification of the threshold beyond which the retailer accepts the transshipment to design of available stock.
We focus here on determining, the policy of transshipment in a centralized stock system which seeks to improve the Average Global Profit at the two retailers by minimizing the Average Global Desservice Rate as much as possible.
In this section of chapter, we formulate the Average Global Desservice Rate for the two retailers by Eq. (14).
(this is the Average Global Desservice Rate).
From the analysis in Table 6, we note that the Average Global Desservice Rate has a strong relationship with the change in periodicity and it increases beyond k = 4, and becomes in the form of a increasing curve.
k | Without-transshipment | Complete-pooling | Partial-pooling | ||
---|---|---|---|---|---|
Twice the demand | Next demand | Security Stock = 30% of PSiT | |||
2 | 0.500 | 0.360 | 0.340 | 0.120 | 0.060 |
3 | 0.600 | 0.460 | 0.432 | 0.097 | 0.050 |
4 | 0.450 | 0.159 | 0.148 | 0.053 | 0.032 |
5 | 0.670 | 0.357 | 0.351 | 0.157 | 0.067 |
6 | 0.750 | 0.465 | 0.457 | 0.195 | 0.090 |
7 | 0.865 | 0.525 | 0.512 | 0.293 | 0.120 |
8 | 0.925 | 0.620 | 0.602 | 0.387 | 0.202 |
9 | 1.005 | 0.770 | 0.720 | 0.492 | 0.297 |
10 | 1.121 | 0.800 | 0.795 | 0.537 | 0.325 |
Determination of average global desservice rate.
But, we analyze the effect of transshipment policies on the minimization of the Average Global Desservice Rate. We notice then that, the first transshipment policy “Complete-Pooling” aims to decrease the rate of the quantity of customer orders not satisfied whatever the periodicity and for example for k = 2 this reduction is worth from 0.500 to 0.360 and that the second “Partial-Pooling” policy aims to reduce it as soon as possible and this will be explicit for the last transshipment threshold which equals
We then note that the collaboration between two sites 1 and 2 increases the probability of cycles without shortages in each warehouse by the quantity of transshipment transferred planned from 2 to 1 and likewise from 1 to 2 for an increase in the quantity to order for the site 1 and for site 2. Which results in the probability of customer satisfaction improves after the application of the transshipment.
We will then conclude that, the level of service in a collaborative network is higher compared to the network of independent sites and this plays a very important role in decreasing the amount of lost order. This implies that the economic performance of the group of employees does not only depend on the characteristics of each isolated site, it also depends on the characteristics of each retailer and its relationship with the other depots that make up the inventory system and especially when the cost of transfer lateral is weak. This conclusion should be taken into account in the training of employee groups.
This chapter targets to study the effect of collaboration in emergencies and applying two policy of transshipment named, “Complete-Pooling” and “Partial-Pooling” between two storage sites on the overall average profit of the system centralized and customer Desservice level.
The most important conclusions can be summarized in the following:
The sharing of stocks between sites of the same level greatly optimizes the Average Global Profit of the entire system;
Collaboration between sites always improves customer Average Global Desservice Rate, i.e. the probability of no-shortage cycles and the probability of customer satisfaction;
In general, the positive effect of collaboration is greater when we apply the “partial pooling” policy with a change in the transshipment threshold.
Several extensions of this model that are of particular interest can be considered in future research. For example, the variation in the average and the standard deviation of the random customer demand and the use of the larger network where the number of sites exceeds the two, integrating the distance between the different storage sites located at the same level.
IntechOpen publishes different types of publications
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\\n\\nPERSPECTIVE CHAPTER – A perspective chapter offers a new point of view on existing problems, fundamental concepts, or common opinions on a specific topic. Perspective chapters can propose or support new hypotheses, or discuss the significance of newly achieved innovations. Perspective chapters can focus on current advances and future directions on a topic and include both original data and personal opinion.
\\n\\nINTRODUCTORY CHAPTER – An introductory chapter states the purpose and goals of the book. The introductory chapter is written by the Academic Editor.
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science and industry. Experimentation is an application of treatments applied to experimental units and is then part of a scientific method based on the measurement of one or more responses. It is necessary to observe the process and the operation of the system well. For this reason, in order to obtain a final result, an experimenter must plan and design experiments and analyzes the results. One of the most commonly used experimental designs for optimization is the response surface methodology (RSM). Because it allows evaluating the effects of multiple factors and their interactions on one or more response variables it is a useful method. In this section, recent studies have been compiled which aim to extraction of plant material in high yield and quality and determine optimum conditions for this extraction process.",book:{id:"5856",slug:"statistical-approaches-with-emphasis-on-design-of-experiments-applied-to-chemical-processes",title:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes",fullTitle:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes"},signatures:"Alev Yüksel Aydar",authors:[{id:"218870",title:"Dr.",name:"Alev Yüksel",middleName:null,surname:"Aydar",slug:"alev-yuksel-aydar",fullName:"Alev Yüksel Aydar"}]},{id:"56460",doi:"10.5772/intechopen.69501",title:"Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes",slug:"application-of-taguchi-based-design-of-experiments-for-industrial-chemical-processes",totalDownloads:3157,totalCrossrefCites:23,totalDimensionsCites:47,abstract:"Design of experiment is the method, which is used at a very large scale to study the experimentations of industrial processes. It is a statically approach where we develop the mathematical models through experimental trial runs to predict the possible output on the basis of the given input data or parameters. The aim of this chapter is to stimulate the engineering community to apply Taguchi technique to experimentation, the design of experiments, and to tackle quality problems in industrial chemical processes that they deal with. Based on years of research and applications, Dr. G. Taguchi has standardized the methods for each of these DOE application steps. Thus, DOE using Taguchi approach has become a much more attractive tool to practicing engineers and scientists. And since the last four decades, there were limitations when conventional experimental design techniques were applied to industrial experimentation. And Taguchi, also known as orthogonal array design, adds a new dimension to conventional experimental design. Taguchi method is a broadly accepted method of DOE, which has proven in producing high-quality products at subsequently low cost.",book:{id:"5856",slug:"statistical-approaches-with-emphasis-on-design-of-experiments-applied-to-chemical-processes",title:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes",fullTitle:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes"},signatures:"Rahul Davis and Pretesh John",authors:[{id:"199438",title:"Mr.",name:"Rahul",middleName:null,surname:"Davis",slug:"rahul-davis",fullName:"Rahul Davis"}]},{id:"14634",doi:"10.5772/15998",title:"The Application of FT-IR Spectroscopy in Waste Management",slug:"the-application-of-ft-ir-spectroscopy-in-waste-management",totalDownloads:6613,totalCrossrefCites:18,totalDimensionsCites:34,abstract:null,book:{id:"1574",slug:"fourier-transforms-new-analytical-approaches-and-ftir-strategies",title:"Fourier Transforms",fullTitle:"Fourier Transforms - New Analytical Approaches and FTIR Strategies"},signatures:"Ena Smidt, Katharina Böhm and Manfred Schwanninger",authors:[{id:"20376",title:"Dr.",name:"Katharina",middleName:null,surname:"Böhm",slug:"katharina-bohm",fullName:"Katharina Böhm"},{id:"22840",title:"Dr.",name:"Ena",middleName:null,surname:"Smidt",slug:"ena-smidt",fullName:"Ena Smidt"},{id:"22915",title:"Dr.",name:"Manfred",middleName:null,surname:"Schwanninger",slug:"manfred-schwanninger",fullName:"Manfred Schwanninger"}]},{id:"15157",doi:"10.5772/15959",title:"Fourier Transform Mass Spectrometry for the Molecular Level Characterization of Natural Organic Matter: Instrument Capabilities, Applications, and Limitations",slug:"fourier-transform-mass-spectrometry-for-the-molecular-level-characterization-of-natural-organic-matt",totalDownloads:4317,totalCrossrefCites:6,totalDimensionsCites:33,abstract:null,book:{id:"122",slug:"fourier-transforms-approach-to-scientific-principles",title:"Fourier Transforms",fullTitle:"Fourier Transforms - Approach to Scientific Principles"},signatures:"Rachel L. Sleighter and Patrick G. Hatcher",authors:[{id:"22676",title:"Dr.",name:"Rachel L.",middleName:null,surname:"Sleighter",slug:"rachel-l.-sleighter",fullName:"Rachel L. Sleighter"},{id:"23168",title:"Dr.",name:"Patrick G.",middleName:null,surname:"Hatcher",slug:"patrick-g.-hatcher",fullName:"Patrick G. Hatcher"}]},{id:"60097",doi:"10.5772/intechopen.75381",title:"Robust Optimization: Concepts and Applications",slug:"robust-optimization-concepts-and-applications",totalDownloads:2509,totalCrossrefCites:21,totalDimensionsCites:28,abstract:"Robust optimization is an emerging area in research that allows addressing different optimization problems and specifically industrial optimization problems where there is a degree of uncertainty in some of the variables involved. There are several ways to apply robust optimization and the choice of form is typical of the problem that is being solved. In this paper, the basic concepts of robust optimization are developed, the different types of robustness are defined in detail, the main areas in which it has been applied are described and finally, the future lines of research that appear in this area are included.",book:{id:"6587",slug:"nature-inspired-methods-for-stochastic-robust-and-dynamic-optimization",title:"Nature-inspired Methods for Stochastic, Robust and Dynamic Optimization",fullTitle:"Nature-inspired Methods for Stochastic, Robust and Dynamic Optimization"},signatures:"José García and Alvaro Peña",authors:[{id:"227809",title:"Ph.D.",name:"Jose",middleName:null,surname:"Garcia",slug:"jose-garcia",fullName:"Jose Garcia"},{id:"240407",title:"Dr.",name:"Alvaro",middleName:null,surname:"Peña",slug:"alvaro-pena",fullName:"Alvaro Peña"}]}],mostDownloadedChaptersLast30Days:[{id:"59209",title:"Utilization of Response Surface Methodology in Optimization of Extraction of Plant Materials",slug:"utilization-of-response-surface-methodology-in-optimization-of-extraction-of-plant-materials",totalDownloads:5300,totalCrossrefCites:47,totalDimensionsCites:76,abstract:"Experimental design plays an important role in several areas of science and industry. Experimentation is an application of treatments applied to experimental units and is then part of a scientific method based on the measurement of one or more responses. It is necessary to observe the process and the operation of the system well. For this reason, in order to obtain a final result, an experimenter must plan and design experiments and analyzes the results. One of the most commonly used experimental designs for optimization is the response surface methodology (RSM). Because it allows evaluating the effects of multiple factors and their interactions on one or more response variables it is a useful method. In this section, recent studies have been compiled which aim to extraction of plant material in high yield and quality and determine optimum conditions for this extraction process.",book:{id:"5856",slug:"statistical-approaches-with-emphasis-on-design-of-experiments-applied-to-chemical-processes",title:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes",fullTitle:"Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes"},signatures:"Alev Yüksel Aydar",authors:[{id:"218870",title:"Dr.",name:"Alev Yüksel",middleName:null,surname:"Aydar",slug:"alev-yuksel-aydar",fullName:"Alev Yüksel Aydar"}]},{id:"74096",title:"Time Frequency Analysis of Wavelet and Fourier Transform",slug:"time-frequency-analysis-of-wavelet-and-fourier-transform",totalDownloads:1158,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"Signal processing has long been dominated by the Fourier transform. However, there is an alternate transform that has gained popularity recently and that is the wavelet transform. The wavelet transform has a long history starting in 1910 when Alfred Haar created it as an alternative to the Fourier transform. In 1940 Norman Ricker created the first continuous wavelet and proposed the term wavelet. Work in the field has proceeded in fits and starts across many different disciplines, until the 1990’s when the discrete wavelet transform was developed by Ingrid Daubechies. While the Fourier transform creates a representation of the signal in the frequency domain, the wavelet transform creates a representation of the signal in both the time and frequency domain, thereby allowing efficient access of localized information about the signal.",book:{id:"10065",slug:"wavelet-theory",title:"Wavelet Theory",fullTitle:"Wavelet Theory"},signatures:"Karlton Wirsing",authors:[{id:"325178",title:"Dr.",name:"Karlton",middleName:null,surname:"Wirsing",slug:"karlton-wirsing",fullName:"Karlton Wirsing"}]},{id:"60864",title:"Statistical Methodology for Evaluating Business Cycles with the Conditions of Their Synchronization and Harmonization",slug:"statistical-methodology-for-evaluating-business-cycles-with-the-conditions-of-their-synchronization-",totalDownloads:1288,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"The importance of the topic of business cycle research and their interaction is due to the fact that the cyclical nature of development is a universal feature of the market economy (regardless of the level of development of the country’s economy and the principles of its organization). In all cases, cyclical ups and downs depend not only on internal system cyclical processes and their factors in countries but also on the consequences of intercountry interaction. The ability to measure and predict business cycles, taking into account their mutual influence, is a prerequisite for the development of an adequate business policy of countries and their associations.",book:{id:"6703",slug:"statistics-growing-data-sets-and-growing-demand-for-statistics",title:"Statistics",fullTitle:"Statistics - Growing Data Sets and Growing Demand for Statistics"},signatures:"Elena Zarova",authors:null},{id:"54366",title:"Solution of Differential Equations with Applications to Engineering Problems",slug:"solution-of-differential-equations-with-applications-to-engineering-problems",totalDownloads:6750,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"Over the last hundred years, many techniques have been developed for the solution of ordinary differential equations and partial differential equations. While quite a major portion of the techniques is only useful for academic purposes, there are some which are important in the solution of real problems arising from science and engineering. In this chapter, only very limited techniques for solving ordinary differential and partial differential equations are discussed, as it is impossible to cover all the available techniques even in a book form. The readers are then suggested to pursue further studies on this issue if necessary. After that, the readers are introduced to two major numerical methods commonly used by the engineers for the solution of real engineering problems.",book:{id:"5513",slug:"dynamical-systems-analytical-and-computational-techniques",title:"Dynamical Systems",fullTitle:"Dynamical Systems - Analytical and Computational Techniques"},signatures:"Cheng Yung Ming",authors:[{id:"191017",title:"Dr.",name:"Cheng",middleName:null,surname:"Y.M.",slug:"cheng-y.m.",fullName:"Cheng Y.M."}]},{id:"56538",title:"Stochastic Resonance and Related Topics",slug:"stochastic-resonance-and-related-topics",totalDownloads:1675,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The stochastic resonance (SR) is the phenomenon which can emerge in nonlinear dynamic systems. In general, it is related with a bistable nonlinear system of Duffing type under additive excitation combining deterministic periodic force and Gaussian white noise. It manifests as a stable quasiperiodic interwell hopping between both stable states with a small random perturbation. Classical definition and basic features of SR are regarded. The most important methods of investigation outlined are: analytical, semi-analytical, and numerical procedures of governing physical systems or relevant Fokker-Planck equation. Stochastic simulation is mentioned and experimental way of results verification is recommended. Some areas in Engineering Dynamics related with SR are presented together with a particular demonstration observed in the aeroelastic stability. Interaction of stationary and quasiperiodic parts of the response is discussed. Some nonconventional definitions are outlined concerning alternative operators and driving processes are highlighted. The chapter shows a large potential of specific basic, applied and industrial research in SR. This strategy enables to formulate new ideas for both development of nonconventional measures for vibration damping and employment of SR in branches, where it represents an operating mode of the system itself. Weaknesses and empty areas where the research effort of SR should be oriented are indicated.",book:{id:"6128",slug:"resonance",title:"Resonance",fullTitle:"Resonance"},signatures:"Jiří Náprstek and Cyril Fischer",authors:[{id:"207472",title:"Dr.",name:"Jiri",middleName:null,surname:"Naprstek",slug:"jiri-naprstek",fullName:"Jiri Naprstek"},{id:"213311",title:"Dr.",name:"Cyril",middleName:null,surname:"Fischer",slug:"cyril-fischer",fullName:"Cyril Fischer"}]}],onlineFirstChaptersFilter:{topicId:"15",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"80460",title:"A Criticality Study of Fast Critical Experimental Benchmarks Using MCNP Code to Qualifying Different Evaluations",slug:"a-criticality-study-of-fast-critical-experimental-benchmarks-using-mcnp-code-to-qualifying-different",totalDownloads:1,totalDimensionsCites:null,doi:"10.5772/intechopen.102449",abstract:"In this chapter we present our MCNP modeling, concerning fast critical experimental benchmarks, about qualifying our libraries of cross-sections deduced from the evaluations ENDF/B-VII, JEFF-3.1, JENDL-3.3, JENDL-4 processed by the code NJOY. The benchmarks analyzed are characterized by simple geometries which help to have a precise calculation. In our neutron calculation, we used the MCNP code (version 5), the reference code for the neutron transport calculation with the Monte Carlo method. It is also very efficient for criticality calculation. The cross-section data for all the isotopes that make up the material of the studied benchmarks are processed in ACE format at 300 K temperature using the NJOY 99.9 modular system. A detailed comparison of the criticality results of our simulation was carried out to highlight the influence of these evaluations on the keff calculations.",book:{id:"11501",title:"Qualitative and Computational Aspects of Dynamical Systems",coverURL:"https://cdn.intechopen.com/books/images_new/11501.jpg"},signatures:"Sanae El Ouahdani, Hamid Boukhal, El Mahjoub Chakir, Ahmed Gaga, Houda Elyaakoubi, Mustapha Makhloul, Abdelaziz Ahmed, Abdessamad Didi and Mohamed Bencheikh"},{id:"81784",title:"Practical and Optimal Crossover Designs for Clinical Trials",slug:"practical-and-optimal-crossover-designs-for-clinical-trials",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.104694",abstract:"Crossover designs have received great attention in clinical trials, as they allow subjects to serve as their own controls and gain such advantage as higher efficiency and smaller sample size over parallel designs, because the within-subject variability is in general smaller than between-subject variability. Response-adaptive crossover designs allow clinical trials to adapt and respond to the information acquired during the trials to achieve various objectives. Adaptive designs have been considered to allocate more subjects to superior treatments, improve statistical efficiency, reduce the sample size for cost savings, increase the sample size to maintain prespecified statistical power, or include auxiliary information. We focus on an adaptive allocation scheme to maximize the benefits from superior treatments, while maintaining a sufficiently high level of statistical efficiency, controlled by a suitable weight parameter. We review and discuss the strategy of incorporating multiple objectives, while advocating a regression type estimation approach via the Generalized Estimating Equations method. We show that the multiple objectives can be successfully incorporated to construct a spectrum of designs, ranging over various efficiencies and trial outcomes of success. Moreover, the adaptive allocation scheme successfully constructs designs with a desired efficiency, as illustrated by practical two- and three-period designs.",book:{id:"10678",title:"Biostatistics",coverURL:"https://cdn.intechopen.com/books/images_new/10678.jpg"},signatures:"Su Hwan Kim and Keumhee Chough Carriere"},{id:"81710",title:"Spatial Modeling in Epidemiology",slug:"spatial-modeling-in-epidemiology",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104693",abstract:"The objective of this chapter is to present the methodology of some of the models used in the area of epidemiology, which are used to study, understand, model and predict diseases (infectious and non-infectious) occurring in a given region. These models, which belong to the area of geostatistics, are usually composed of a fixed part and a random part. The fixed part includes the explanatory variables of the model and the random part includes, in addition to the error term, a random term that generally has a multivariate Gaussian distribution. Based on the random effect, the spatial correlation (or covariance) structure of the data will be explained. In this way, the spatial variability of the data in the region of interest is accounted for, thus avoiding that this information is added to the model error term. The chapter begins by introducing Gaussian processes, and then looks at their inclusion in generalized spatial linear models, spatial survival analysis and finally in the generalized extreme value distribution for spatial data. The review also mentions some of the main packages that exist in the R statistical software and that help with the implementation of the mentioned spatial models.",book:{id:"10678",title:"Biostatistics",coverURL:"https://cdn.intechopen.com/books/images_new/10678.jpg"},signatures:"María Guzmán Martínez, Eduardo Pérez-Castro, Ramón Reyes-Carreto and Rocio Acosta-Pech"},{id:"81608",title:"Matrix as an Alternative Solution for Evaluating Sentence Reordering Tasks",slug:"matrix-as-an-alternative-solution-for-evaluating-sentence-reordering-tasks",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.102868",abstract:"Although sentence reordering is a popular practice in educational contexts its scoring method has virtually remained ‘all-or-nothing’. The author proposed a more psychologically valid means of partial scoring called MRS (Maximal Relative Sequence) where a point is counted for each ascending run in the answer sequence allowing gaps and the final score reflects the length of the longest sequence of ascending elements. This scoring method, together with an additional consideration of recovery distances, was woven into an executable programme, and then transplanted to Excel without having to understand a programming language. However, the use of Excel was severely limited by the number of columns available. This chapter reviews the past practices of evaluating partial scoring of reordering tasks and proposes an alternative solution LM (Linearity Matrix), also executable on Excel, with far smaller consumption of columns and with the idea of calculating the recovery distances as well as MRS scores. Although LM and MRS are different scoring procedures, they both reflect psychological complexity of the task involved. Furthermore, LM is versatile as to the adjustability of adjacency weights as an extended model of Kendall’s tau. Some reflections on practical application are referred to as well as future directions of the study.",book:{id:"11151",title:"Matrix Theory - Classics and Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11151.jpg"},signatures:"Amma Kazuo"},{id:"81531",title:"Bayesian Inference as a Tool to Optimize Spectral Acquisition in Scattering Experiments",slug:"bayesian-inference-as-a-tool-to-optimize-spectral-acquisition-in-scattering-experiments",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.103850",abstract:"Nowadays, an increasing number of scattering measurements rely on the use of large-scale research facilities, which is usually granted after highly competitive peer-reviewing and typically for short-time lapses. The optimal use of the allocated time requires rigorous estimates on the reliability of the data analysis, as inferred from the limited statistical accuracy of the measurement. Bayesian inference approaches can significantly help this endeavor by providing investigators with much-needed guidance under challenging decisions on experimental time management. We propose here a method based on the real-time data analysis of running experiments, which fully exploits the core strengths of Bayes theorem. The procedure is implemented in sequential steps in which the spectral measurement is adjourned by summing to it successive acquisition runs, and the spectral modeling is upgraded accordingly. At each stage, the statistical accuracy of the measurement improves, and a more grounded joint posterior distribution is drawn and used as a prior in the subsequent data acquisition stage. The gradual reduction in the model parameters’ uncertainty down to the targets set a priori by experimenters provides a quantitative “success criterion,” which helps prevent oversampling during acquisition. A similar “on the fly” data modeling, might substantially change the way large-scale facilities operate.",book:{id:"11152",title:"Bayesian Inference",coverURL:"https://cdn.intechopen.com/books/images_new/11152.jpg"},signatures:"Alessio De Francesco, Luisa Scaccia, Martin Bohem and Alessandro Cunsolo"},{id:"81492",title:"Clustering Network Data Using Mixed Integer Linear Programming",slug:"clustering-network-data-using-mixed-integer-linear-programming",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.104760",abstract:"Network clustering provides insights into relational data and feeds certain machine learning pipelines. We present five integer or mixed-integer linear programming formulations from literature for a crisp clustering. The first four clustering models employ an undirected, unweighted network; the last one employs a signed network. All models are coded in Python and solved using Gurobi solver. Codes for one of the models are explained. All codes and datasets are made available. The aim of this chapter is to compare some of the integer or mixed-integer programming network clustering models and to provide access to Python codes to replicate the results. Mathematical programming formulations are provided, and experiments are run on two different datasets. Results are reported in terms of computational times and the best number of clusters. The maximum diameter minimization model forms compact clusters including members with a dominant affiliation. The model generates a few clusters with relatively larger size. Additional constraints can be included to force bounds on the cluster size. The NP-hard nature of the problem limits the size of the dataset, and one of the models is terminated after 6 days. The models are not practical for networks with hundreds of nodes and thousands of edges or more. 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. 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He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. 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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. 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At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",mid