The environmental measurement and physiological responses of dairy cows in the experimental housing. (MeanS.E.M.)
\r\n\tGenetically susceptible individuals seem to have a dysregulated mucosal immune response to commensal gut flora, but environmental factors might trigger the disease onset.
\r\n\r\n\tThe clinical course of ulcerative colitis is characterized by alternating periods of remission and relapse, with extension of colonic disease in time, but with similar mortality to the general population.
\r\n\tThe treatment is complex, targeting the induction of response and remission, followed by maintenance of remission, and surgery in case of emergencies, refractoriness or intolerance to long-term maintenance treatments , or dysplasia or colorectal cancer.
\r\n\tThis book intends to provide the reader with a comprehensive overview of the current state-of-the-art in patient’s epidemiology, physiopathology, diagnosis, complications and therapy, focusing on the most important evidence-based developments in this critically important area.
",isbn:"978-1-80355-295-8",printIsbn:"978-1-80355-294-1",pdfIsbn:"978-1-80355-296-5",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"2fdca8f4b6693fd5d0882b9e35517b7f",bookSignature:"Dr. Partha Pal",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11268.jpg",keywords:"Epidemiology, Etiology, Genetics, Physiopathology, Ulcerative Colitis, Imaging, Immunology, Biological Therapy, Surgery, Diet, Mortality, Quality Of Life",numberOfDownloads:320,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 31st 2021",dateEndSecondStepPublish:"September 28th 2021",dateEndThirdStepPublish:"November 27th 2021",dateEndFourthStepPublish:"February 15th 2022",dateEndFifthStepPublish:"April 16th 2022",remainingDaysToSecondStep:"8 months",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Pal has published more than 50 peer-reviewed articles primarily in Inflammatory bowel\r\ndisease, small bowel, and interventional endoscopy. He won the National Young Scholar Award for\r\nGastroenterology in 2017. Recently he received the prestigious ASGE Endoscopic Training Award\r\nin 2021.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"345620",title:"Dr.",name:"Partha",middleName:null,surname:"Pal",slug:"partha-pal",fullName:"Partha Pal",profilePictureURL:"https://mts.intechopen.com/storage/users/345620/images/system/345620.jpg",biography:null,institutionString:"Asian Institute of Gastroenterology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Asian Institute of Gastroenterology",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:[{id:"80048",title:"Complications of Ulcerative Colitis in Children",slug:"complications-of-ulcerative-colitis-in-children",totalDownloads:44,totalCrossrefCites:0,authors:[{id:"51575",title:"Dr.",name:"Sabina",surname:"Wiecek",slug:"sabina-wiecek",fullName:"Sabina Wiecek"}]},{id:"80179",title:"Pediatric Ulcerative Colitis",slug:"pediatric-ulcerative-colitis",totalDownloads:65,totalCrossrefCites:0,authors:[null]},{id:"80050",title:"Platelets in Ulcerative Colitis: From Pathophysiology to Therapy",slug:"platelets-in-ulcerative-colitis-from-pathophysiology-to-therapy",totalDownloads:41,totalCrossrefCites:0,authors:[null]},{id:"80116",title:"The Role of the Pathologist in Ulcerative Colitis",slug:"the-role-of-the-pathologist-in-ulcerative-colitis",totalDownloads:66,totalCrossrefCites:0,authors:[null]},{id:"80693",title:"Dietary Fermented Rice Bran Is an Effective Modulator of Ulcerative Colitis in Experimental Animal",slug:"dietary-fermented-rice-bran-is-an-effective-modulator-of-ulcerative-colitis-in-experimental-animal",totalDownloads:47,totalCrossrefCites:0,authors:[null]},{id:"80182",title:"Histomorphological Diagnosis of Ulcerative Colitis and Associated Conditions",slug:"histomorphological-diagnosis-of-ulcerative-colitis-and-associated-conditions",totalDownloads:57,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"429342",firstName:"Zrinka",lastName:"Tomicic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/429342/images/20008_n.jpg",email:"zrinka@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"39478",title:"Alleviating Heat Stress Leads to Improved Cow Reproductive Performance",doi:"10.5772/50881",slug:"alleviating-heat-stress-leads-to-improved-cow-reproductive-performance",body:'Thailand, a country situated in the south eastern part of Asia, is situated in between 15° 00\' North latitude and 100° 00\' East longitude and located in a tropical area with high temperature and humidity. Crossbred Holstein dairy cattle are popular because, during times of high environmental thermal stress, their milk production and reproductive efficiency is not depressed as it is with purebred Holstein cattle. However, these crossbred cattle have been inseminated with purebred Holstein frozen semen to improve milk production. Although the genetic potential for milk yield has improved, the predominant dairy breed has now become Holstein and the impact of heat stress on production and reproduction has increased.
This chapter will be showed the finding of our studied that show the impact of heat stress on postpartum reproductive performance and milk production and evaluate the effects of utilizing an evaporative cooling system for improving cow comfort, energy balance, postpartum reproductive performance and milk production of early lactating dairy cows under hot and humid climatic conditions.
Climatic conditions in the tropics are such that the hot season is relatively long, there is intense radiant energy for an extended period of time, and there is generally high relative humidity. Thus heat stress is chronic in nature, there is often little relief from the heat during the night, and intense bursts of combined heat and humidity depress performance. Lactating dairy cows create a large quantity of metabolic heat and accumulate additional heat from radiant energy. Heat production and heat accumulation, coupled with a compromised cooling capability, because of environmental conditions, causes heat load in the cows to increase to a point when body temperature rises, feed intake declines and ultimately the cow’s productivity falls.
During period of elevated temperature, animals show less physical activity and seek shelter to decrease radiant heat exposure. Elevated body temperatures will rapidly trigger adaptive mechanisms to restore body temperature to normal. These adaptations, including panting, sweating, reduced feed intake and lowered metabolism, may be necessary for survival, but they are not generally favorable to milk production [1]. Moreover, because of their relative size and their high metabolic rate, associated with milk production, dairy cows are particularly susceptible to the effects of heat stress.
Heat stress has a significant impact on dairy cattle in hot and humid climates. Environmental factors, which contribute to heat stress, include high ambient temperatures, radiant energy, and high humidity, all of which compromise the cow’s ability to dissipate body heat. When the cow cannot dissipate sufficient heat to maintain thermal balance, body temperature rises and heat stress occurs. Ambient temperature is a major component of heat stress, however humidity must also be considered because evaporative heat loss is more effective when humidity is low. The temperature-humidity index (THI) combines these two factors into an indicator of cow comfort. Cows are beginning to be stressed when the THI exceeds 72 [2].
Dairy cows have several mechanisms to help dissipate body heat and maintain body temperature, such as; conduction, convection, radiation and evaporation. Conduction, convection, and radiation depend on a relatively large differential between the body and the environmental temperature, and evaporation works bests at a low relative humidity. When the environmental temperature nears the cow’s body temperature and is coupled with high relative humidity, all the cow’s cooling mechanisms are impaired. As a result the cow’s body temperature rises and the cows exhibits physiological responses to hot weather. Cows in hot climates generally produce additional heat, compared to those in cool climates, because of greater physical activity (such as panting) which is necessary to enhance cooling in hot conditions. In addition lactating dairy cows produce large amounts of heat from both ruminal fermentation and metabolic processes. As production increases, the total amount of heat produced increases. In order to maintain body temperature within the normal range, dairy cows must exchange this heat with the environment. The most noticeable response to heat stress is reduced feed intake, reduced milk yield, reduced activity, and increased respiration rate and water intake.
Temperature and humidity combine to decrease dry matter intake (DMI) in dairy cows as a physiological means of regulating internal body temperature. This is accomplished by decreasing rumen fermentation and the metabolic rate [3,4]. A reduction in DMI decreases the nutrients available for milk synthesis, milk production declines and many lactation parameters are affected [5-7]. High environmental temperatures also increase the respiration rate and the water intake, which consequently reduces DMI due to gut full [8]. Because of many dairy cows in hot weather are unable to consume enough feed to meet energy demands during early lactation, they typically mobilize body reserves to maintain their milk production until the intake of feed can match or exceed nutritional requirements [9,10] thus, entering a state of negative energy balance (NEB).
In heat stressed dairy cows there is a reduction in DMI [11], which prolongs the period of negative energy balance. Negative energy balance leads to decreased plasma concentration of insulin, glucose and insulin-like growth factor-I (IGF-I), and increased plasma concentrations of growth hormone (GH) and non-esterified fatty acid (NEFA) [12,13]. All of these metabolic hormones can affect reproduction. Metabolic hormones acting on the hypothalamo-pituitary axis and the ovary probably mediate the inhibitory effects of negative energy balance on postpartum fertility.
Heat stress affects reproductive performance both by direct action on reproduction and by indirect actions mediated through alterations in energy balance. There is an interaction between DMI, stage of lactation, milk production, energy balance and heat stress, that results in reduced luteinizing hormone (LH) secretion and a decreased diameter of the dominant follicle in the postpartum period [14], this results in reduced oestradiol secretion from the dominant follicle, leading to poor expression of oestrus. The postpartum anovulatory interval of dairy cow, is characterized by a variable period of negative energy balance that is reported to modulate the recrudescence of ovarian cyclicity [9,15,16]. In heat stressed cows, motor activity and other manifestations of oestrus are reduced [17] and the incidence of anoestrus and silent ovulation are increased [18].
There is a decrease in fertility in lactating dairy cows during summer in hot climate [19]. The magnitude of the depression depends on the geographical location and the milk yield [20-22]. In tropical climates, high ambient temperatures and humidity are important determinants of reproductive performance. Heat stress decreases the intensity and duration of oestrus, which in turn reduces both the number of inseminations and the pregnancy rates [23]. Heat stress alters the concentration of circulating hormones by increasing the circulating concentration of corticosteroids [24] and by reducing progesterone concentration [25]. The viability of pre-fixation embryos is reduced [26], and the uterine environment is altered by a decreased blood flow [27] and increased uterine temperature [28]. These changes are associated with increased early embryonic loss and a reduced proportion of successful inseminations. Cows exposed to heat stress have a high incidence of early embryonic mortality [26,29], and some of this effect is due to the direct effect of elevated temperature on the embryo [30].
Lactating dairy cows are susceptible to heat stress because of the elevated internal heat production which is associated with lactation. During periods of heat stress, milk production, feed intake, and physical activity are decreased [11]. At the same time, reproductive ability is compromised [31,32]. The exposure of lactating cows to heat stress has been shown to cause a decrease in follicular growth and to reduce serum estradiol [33],which also concluded that decreased follicular size or decreased dominant follicle function occurred in lactating cows that were exposed to heat stress[34,35]. Some of the reproductive losses, in heat stressed cattle, are associated with decreased expression of oestrus caused by anoestrus and silent ovulation [36,37]. Heat stress delays follicle selection and lengthens the follicular wave having potentially adverse effects on oocytes quality [34] and follicular steroidogenesis [35].
Heat stress cause infertility and represented a major source of economic loss in dairy cows under tropical conditions. In recent study, the conception rate of dairy cows in Thailand decrease 20-30 % in hot season. The conception rate was lower in April and May when compared to other month, which lowest in summer and highest in winter (Figure 1). The effects of heat stress can be directly related to the increase in body temperature of dairy cow, which affects the reproductive function and embryonic development.
Conception rates of dairy cows in commercial farm located in the central part of Thailand.
The detrimental effects of heat stress on the reproductive performance of dairy cows have been well documented. These include a suppressed intensity of oestrus, a reduced preovulatory LH surge and decreased secretion of luteal progesterone [25], altered ovarian follicular development [33], decreased embryo development [38] and lower fertility [39]. In an attempt to minimize these effects, modifications to dairy cattle housing environments have been implemented to alleviate thermal stressors and improve cow comfort, through the use of shade, fans, sprinklers, and evaporative cooling [11,37,40]. These methods can enhance pregnancy rates significantly [24,41].
Reducing heat stress in dairy cattle requires a multi-disciplinary approach. It involves breeding for improved heat tolerance, improved nutrition and improved reproductive management for the animals, and improved the structural design and the environmental control of their housing.
Heat stress reduces milk production and reproductive efficiency. In an attempt to minimize these effects, modifications to dairy cattle housing environments have been implemented to alleviate thermal stressors and improve cow comfort [11,37,40,42]. The major objective of any cooling system is to keep the cow’s body temperature as close to normal for as much of the day as possible. An acceptable range in rectal temperature is 38.5-39.3 C. There are two general approaches to cooling dairy cows. One is to modify the environment to prevent heat stress or to utilize methods that increase heat dissipation from the skin surface of cattle. The easiest and most obvious way to help heat-stressed cows is to provide shade. Direct sunlight adds a tremendous heat load to the cow and can be blocked by shades, but shade alone is inadequate to reduce the effect of heat stress. A more economical method to reduce the effect of heat stress is by evaporative cooling. Evaporative cooling can be accomplished by two approaches; 1) direct evaporation from the skin surface of the cows (fan and sprinkler combinations) and 2) indirect evaporation which involve cooling the micro-environment of the cows, with cooling pads and fans, in an enclosed barn. When water evaporates it absorbs heat, there by reducing the temperature and increasing heat dissipation from the skin of cattle. When water evaporates it also increases the relative humidity, due to the increased level of water vapor present. In hot and humid regions, evaporative cooling always requires the use of forced ventilation.
A number of studies have shown that housing systems in hot climates can be modified by the use of evaporative cooling to improve both milk production and reproductive efficiency of dairy cows [43-46]. There is a great potential to reduce temperature and THI. However, as relative humidity increases and or temperature decreases, the potential for evaporative cooling to modify the environment decreases. In hot and humid climates, high relative humidity reduces the potential of evaporative cooling. Therefore, there are questions regarding the effectiveness of evaporative systems in climates with high relative humidity. This chapter showed the impact of heat stress on postpartum cow performances and evaluated the effects of utilizing an evaporative cooling system for improved cow comfort and cow performance of early lactating dairy cows in a hot and humid climate.
The upper critical temperature for heat stress to begin was between 25 and 26C [47]. Climatic conditions in the present study are such that the hot season is relatively long, and generally accompanied by high relative humidity. Thus heat stress is chronic in nature and there is little relief from the heat during the evening through to the morning, and also includes intense bursts of combined heat and humidity which further depresses performance.
Environmental modifications by evaporative cooling system equipped with tunnel ventilation in this study led to a decrease in the ambient temperature and an increase in the relative humidity, during the day. The air temperature in the tunnel barn was up to 6 C cooler (P<0.05) during the daytime than that in the outside barn, while the relative humidity increased by up to 16%. As air was drawn through the wet cooling pads, water was evaporated into the air causing the temperature to be reduced while increasing the air moisture level. The amount of initial moisture in the outside air will directly impact on how much reduction in air temperature might be expected. Therefore, when the outside air is initially very high humid (relative humidity greater than 70%), the reduction in air temperature will be minimal (less than 2.8 to 5.6C).
The average daily minimum and maximum temperatures were 24.2±0.1 and 28.4±0.1C, respectively in the evaporative, cooled tunnel, ventilated barn and 24.7±0.1 and 34.4±0.1C, respectively in the outside barn, indicating less variation and more consistency in this cooling system. This evaporative, cooled tunnel, ventilated barn reduced daily fluctuation in the ambient temperature, relative humidity and THI during hot and humid climatic conditions. Although, this system reduced (P<0.05) afternoon barn temperature, but relative humidity increased (P<0.05) when compared to the barn without a supplemental cooling system.
Although, high environmental relative humidity reduced the cooling capacity of the evaporative cooling, but on the days when animals were observed it reduced heat stress of the lactating dairy cows. This study shows that evaporative cooling with tunnel ventilation reduced the severity of afternoon heat stress in dairy cows. THI in the tunnel ventilated barn was decreased when compared to the outside barn. There was no thermoneutal zone (THI72) during the study but exposure to conditions of moderate heat stress (THI79) that occurred outside was decreased by utilizing the evaporative cooling system. This difference in environmental conditions had a dramatic effect on the physiological response of the cows, as THI was highly correlated with both rectal temperature and respiration rate. The average rectal temperature and respiration rate in the cooled cows was lower (P<0.05) than in the uncooled cows. Changing in cow body temperatures was most sensitive to same day climatic factors [48]. These results suggest that evaporative cooling and tunnel ventilation has the potential to decrease exposure to heat stress and alleviate the symptoms of heat stress.
The average daily THI in the morning and afternoon in the evaporative, cooled tunnel, ventilated barn were lower (P<0.05) than that in the outside barn. However, the mean THI exceeded the critical point of 72 at daytime and nighttime, suggesting that the cows were exposed continuously to conditions conducive to mild heat stress for the cooled cows and moderate heat stress for the uncooled cows. In hot, arid conditions this system would work well and evaporative cooling has already been used very successfully to cool such dairy cows [46], but in high humidity locations its effectiveness would be limited by the evaporation potential. In this study the air temperature increases during the day and decreases in the evening until the next morning. As the air temperature rises during the day, the relative humidity will decrease. Accordingly during the hottest portion of the day, the outside relative humidity dropped to a level that allowed for maximum evaporation potential, making the system effective for reducing the severity of heat stress.
Cooled (inside) | Uncooled (outside) | P-value | |
Number of animals (n) | 17 | 17 | |
Environmental measurement : | |||
Daily minimum temperature (C) | 24.20.1 | 24.70.1 | * |
Daily maximum temperature (C) | 28.40.1 | 34.40.1 | * |
AM milking | |||
Daily mean temperature (C) | 25.30.1 | 25.60.1 | * |
Daily mean relative humidity (%) | 88.50.3 | 91.60.2 | * |
Daily mean THI | 76.00.2 | 76.70.2 | * |
Rectal temperature (C) | 38.40.0 | 39.20.1 | * |
Respiratory rate (breaths/min) | 42.71.4 | 54.51.4 | * |
PM milking | |||
Daily mean temperature (C) | 26.50.1 | 31.40.1 | * |
Daily mean relative humidity (%) | 86.50.3 | 74.60.8 | * |
Daily mean THI | 78.00.2 | 83.10.2 | * |
Rectal temperature (C) | 38.70.0 | 39.70.1 | * |
Respiratory rate (breaths/min) | 46.31.8 | 68.32.2 | * |
The environmental measurement and physiological responses of dairy cows in the experimental housing. (MeanS.E.M.)
Air temperature had the greatest impact on physiological measurement, while radiation was second in importance, followed by vapor pressure and air movement [49]. Increasing the air temperature reduces the temperature differential between the cow’s body temperature and the ambient temperature and decreases the transfer of heat to the environment. As ambient temperatures increase in the presence of low or high relative humidity, the cooling mechanisms employed by the cows shifted from a nonevaporative processes (convective, conductive, and radiation) to evaporative (sweating and panting) [48], this demonstrate that the percentage of cooling originating from the non evaporative processes declines as ambient temperature increases, while the evaporative process increase. As a result the uncooled cows had greater (P<0.05) rectal temperatures and respiration rates than the cooled cows.
Dry matter intake, expressed as kilograms per day (kg of DM/day) was greater (P<0.05) in cooled (12.0 0.2 kg/d) than uncooled cows (9.1 0.2 kg/d). DMI increased (P<0.05) from wk 1 to 22 of lactation in both groups of cows but treatment x week postpartum did not affect (P>0.05) it (Figure 2) [50].
Weekly changes in average daily DMI for the cooled and uncooled cows during the first 22 week postpartum.
Weekly changes in average daily milk production for the cooled and uncooled cows during the first 22 week postpartum.
Daily milk yield was greater (P<0.001) in cooled (16.9 0.3 kg/d) than uncooled (12.6 0.2 kg/d) cows. Daily milk yield increased (P<0.001) from wk 1 to wk 22 of lactation in both groups of cows but treatment x week postpartum did not affect (P>0.50) daily milk yield (Figure 3). The 4% FCM also differ (P<0.001) between cooled and uncooled cows. Cooled cows had more persistent milk production than uncooled cows. Milk composition did not differ (P>0.50) between the groups of cows over the 12 week study (Table 2) [50].
Cooled (inside) | Uncooled (outside) | P-value | |
Dry matter intake (kg/d) | 12.0 0.2 | 9.1 0.2 | 0.001 |
Milk yield (kg/d) | 16.9 0.3 | 12.6 0.2 | 0.001 |
Fat (%) | 3.3 0.6 | 3.4 0.6 | 0.810 |
Protein (mg/ml) | 3.2 0.3 | 3.1 0.3 | 0.650 |
Lactose (mg/ml) | 5.0 0.2 | 5.0 0.2 | 0.571 |
Solid not fat (mg/ml) | 8.9 0.4 | 8.8 0.4 | 0.450 |
Dry matter intake, milk production and milk composition of cooled and uncooled cows during the 12 week study.
In this study, rectal temperature was positively correlated with air temperature and THI but negatively correlated with DMI. Dry matter intake was positively correlated with milk production. Milk yield and DMI exhibited a significant decline when maximum THI reached 77 [51]. There is a significant negative correlation between THI and DMI [52,53], and the effect of THI is probably mediated through the effects of increasing body temperature on cow performance.
Mean air temperature had the greatest influence on milk yield for Holstein cows under hot conditions [48]. The mean daily ambient temperature was highly correlated with the p.m. rectal temperature and milk yield was highly correlated with the cows p.m. rectal temperature. The elevated p.m. rectal temperatures were associated with concomitant reductions in DMI and milk yield [54]. Uncooled cows, in this study, had rectal temperatures exceeded 39C at both the a.m. and the p.m. milking, when cow temperatures should have been near their lowest and highest points, respectively. Such consistently elevated rectal temperatures, result in a significant decline in DMI and milk yield when compare with the cooled cows which had a lower rectal temperature.
The negative effects of heat stress on milk production could be explained by decreased nutrient intake and decreased nutrient uptake by the portal drained viscera of the cow [55]. Blood flow which moves to peripheral tissues for cooling purposes may alter nutrient metabolism and contribute to lower milk yields during hot weather. Providing cows with supplemental shade and cooling to mitigate heat stress has been evaluated in economic terms using the increase in milk production data [2]. Adding sprinklers and fan cooling increased the feed intake (7.1 to 9.2%) and milk production (7.1 to 15.8%), and decreased rectal temperature (-0.4 to -0.5 C) and respiration rate (17.6 to 40.6 %) [56].
In this study the cooling system improved cow comfort and milk production. The cooling system decreased ambient temperatures and THI. The cows with this cooling system had decreased rectal temperatures and respiration rates, and increased feed intake (30.9 %) and milk production (42.5%). In addition, an analysis of the economics in the this study showed that the rate of return on investment in cooling equipment and additional feed plus electric costs of this cooling system, showed it was profitable in hot and humid conditions.
There are questions that arise regarding the cost effectiveness of an evaporative cooling system over a period of years. In this study, an economic analysis of the evaporative cooling system showed that cows in the tunnel ventilation barn produced 5.1 kg/cow/day more than the cows housed outside. The milk price was 11.50 baht/kg. Therefore, the use of tunnel ventilation cooling increased revenue by 58.65 baht/cow/day and increased feed costs by 22.17 baht/cow/day. Thus, income over feed cost was 36.48 baht/cow/day.
The cost of the fan and water pump operation was 6.88 baht/cow/day. The total equipment and supply cost to build the tunnel barn facility was 125,000 baht (for 18 cows), which, when depreciated over the expected life of the equipment (including maintenance costs of 25,000 baht over 5 years), was 4.11 baht/cow/day. Thus, the cows housed in the tunnel barn earned 25.49 baht/day or 3823.50 baht more than the cows housed outside over the 22-week study (Table 3).
Item | Difference | Income-Cost (Baht/cow/day) |
Milk yield (kg/cow/day) | 5.1 | 58.65 |
DMI (kg/cow/day) | 2.9 | -22.17 |
Electric cost (fan & water pump operation) | -6.88 | |
Equipment and maintenance cost (5 years) | -4.11 | |
Total | 25.49 |
The economic analysis of the evaporative cooling system over the first 22 week of lactation in dairy cows.
Responses of dairy cow to heat stress include panting and sweating. If these are not successful in alleviating the heat load, body temperature will rise. Increased body temperature will result in reduced feed intake, higher maintenance requirements (panting) and less efficient productive ability. The higher maintenance requirements dictates that cows need to increase feed intake to maintain milk production. However, this not possible as feed intake declines when ambient temperatures exceeded 26C. For uncooled cows in this study, as a result of this increase in requirement and a decrease in intake, milk production may decline as much as 25-30%, and typically they mobilize body reserves and lose body weight to maintain milk production until the intake of feed can match or exceed nutritional requirements [9,10], thus entering a state of negative energy balance.
The energy balance and body weight of dairy cows is presented in Figure 4 and Figure 5. During 12 wk of lactation, average body weight of postpartum cows was greater in cooled than uncooled cows. In both groups of cows, body weight decreased between wk 1 and 4, and increased between wk 5 and 22. Week postpartum (P<0.001) and treatment (P<0.001) affected EB but treatment x week postpartum was not significant. Cows in both groups entered into NEB immediately after calving. Averaged EB was greater (P<0.001) in cooled (0.916 0.194 Mcal/day) than uncooled cows (-0.268 0.195 Mcal/day). During the 12 week study, the week of EB nadir was at wk 2 in both groups and the degree of EB nadir did not differ significantly (P>0.50) between the groups, although the average was lower in uncooled than cooled cows. After reaching the EB nadir, uncooled cows required more days to reach a positive energy balance than the cooled cows. The first week that EB was greater than zero was at wk 5 in cooled cows and at wk 7 in uncooled cows. Because of dry matter intake in uncooled cows was lower (P<0.05) than in cooled cows. Resulting in uncooled cows having a prolonged period of negative energy balance and postpartum body weight in these cows were lesser (P<0.05) than in cooled cows [50]. The negative energy balance is directly related to the postpartum interval to first ovulation, and follicle size was adversely affected by negative energy balance in early postpartum dairy cows [9]. The average EB during the first 4 week of lactation was negatively correlated to the postpartum interval to first ovulation [57].
Weekly changes in energy balance for the cooled and uncooled cows during the first 12 week postpartum.
Weekly changes in average body weight for the cooled and uncooled cows during the first 22 week postpartum.
The exposure of lactating cows to heat stress has been shown to cause a decrease in follicular growth and to reduce concentrations of serum estradiol [33]. In this study the cooled cows had a greater (P < 0.05) average diameter of the largest ovulatory follicle than the uncooled cows. Heat stress inhibited follicular growth and dominance during the preovulatory period. Abnormal ovarian function in heat stressed cows was manifested as a decrease in the proestrus rise in estradiol, and the smaller size of the second wave dominant follicle [33]. Circulating estradiol concentration during the preovulatory period is necessary to produce an LH surge and ovulation. In addition, a reduced estradiol peak may also alter aspects of the LH surge that could account for some types of anovulation in lactating cows [58]. A reduction of the endogenous LH surge by heat stress was reported in heifers [59]. It has been suggested that these differences are related to preovulatory estradiol levels because the amplitude of tonic LH pulses and GnRH-induced preovulatory plasma LH surges are decreased in cows with low plasma concentrations of estradiol but not in cows with high plasma concentrations of estradiol [60]. Therefore, the synchronization rate in the uncooled cows tended to lower than in the cooled cows. In addition, the ovulation rate in response to a second injection GnRH of Ovsynch was reported to be between 87% [61] and 91% [62] in cycling cows. Therefore a second GnRH injection after the PGF2 treatment might be used to improve the ovulation rate in dairy cows under heat stress.
Cooled | Uncooled | P-value | |
Number of animal (n) | 17 | 17 | |
Synchronization rate (%) | 82.4(14/17) | 52.9(9/17) | 0.08 |
Interval to new follicular wave emergence (day) | 2.2±0.1 | 2.3±0.2 | 0.55 |
Size of the largest ovulatory follicle at PGF2( (mm) | 11.5±0.6 | 10.2±0.5 | 0.12 |
Maximal size of the largest ovulatory follicle (mm) | 14.6±0.5 | 14.2±0.4 | 0.57 |
Growth rate of the largest ovulatory follicle after PGF2( (mm/d) | 0.9±0.1 | 1.1±0.1 | 0.17 |
Interval from PGF2( treatment to ovulation (h) | 83.6±5.1 | 88.0±6.9 | 0.63 |
The effect of evaporative cooling and tunnel ventilation system on follicular development, time of ovulation and the response rates of synchronized cows to GnRH and PGF2. Results are expressed as mean±SEM.
Heat stress can compromise reproductive performance by decreasing the expression of oestrus behavior, altering follicular development, affecting oocyte competence, inhibiting embryonic development due to a reduced synchronization of ovulation response, lowering fertilization rates, and reducing embryo quality. In this study the modification of the barn environment and fixed TAI in lactating dairy cows in a hot and humid climate resulted in higher initial conception rates compared to cows housed in a barn without a supplemental cooling system (43.8 and 23.5%, respectively) (Figure 6). The results indicate that this method has the potential to attenuate some of the detrimental effects of heat stress on embryo survival during this period. Although, initial conception rates in cooled cows was higher than uncooled cows, it was still compromised by heat stress as the conception rate decreased further in both groups, indicating that embryo mortality may still have occurred after that. This was probably due to environmental heat stress [63], which causes maternal body temperature to rise leading to the impairment of embryo survival, or this cooling was not sufficiently cool to protect embryos from direct effect of high temperatures, or early embryos during this period might be sensitive to elevated temperature.
Climatic factors that may influence the degree of heat stress include: temperature, humidity, radiation and wind [32]. The upper critical temperature for heat stress begins between 25 and 26C [47]. When environment temperatures exceed 30C the day after insemination, pregnancy rates were adversely affected in lactating dairy cows than in heifers [64]. Maternal hyperthermia is detrimental to embryonic development and survival [65-67]. The oocyte and early cleavage stage embryo are the most sensitive to heat stress, while embryos that are 3 d or older are more tolerant [26,29]. Conception rates decline from 61 to 45% when rectal temperature 12 h, post breeding, increased by 1C [68]. Furthermore, cattle with a rectal temperature of 40C, as a result of exposure to 32.2 C ambient temperatures for 72 h after inseminating, had conception rates of 0%, compared with a conception rate of 48% when rectal temperature was 38.5C, for cows in an ambient temperature of 21.1 C [68]. Given that exposure to conditions of high environmental temperature and humidity has been shown to elevate rectal and uterine temperatures [28].
The conception rate after the synchronization of ovulation and fixed time AI of cooled and uncooled cows.
The modified environment had been used to reduce the effect of heat stress, however, this approach has not eliminated all problems. Timed AI might be particularly effective during heat stress periods because of the decreased incidence of missed oestrus, but heat stress has also a direct effect on the development of the embryo. Conception rates have ranged between 31 to 42 % in cows following the Ovsynch protocol [69-73]. However, conception rates in heat-stressed cows following the Ovsynch protocol were lower than in non stressed cows.
Timed AI programs based on follicular recruitment by synchronized ovulation have been developed [74]. The submission rates and pregnancy rates between d 27 and 30 were enhanced when a TAI program was used. However, the advantage was lost between d 40 and 50 due to increased embryonic mortality in the cows bred using TAI [75]. These results may indicate that cows were successfully induced to ovulate and subsequently conceive but had a reduced ability to maintain pregnancy. Previous studies also showed high (9.3 to 16.8 %) pregnancy losses between 28 and 56 d after AI [76,77].
In recent study, reported that dairy cow had a cumulative hours of body temperature greater than 38.5C more than 4-8 h per day, significantly (P<0.05) decline (Figure 7) in conception rate [78]. This study indicated that long period of hyperthermia (body temperature > 38.5C) had an adverse effect on dairy cows and suggested that dairy cows in the tropical area need additional cooling system to completely eliminate heat stress result in close to normal fertility of dairy cows depend on the severity of the local environment conditions. In addition,
This chart show conception rates of dairy cows. It also illustrated that cow had cumulative hours of hyperthermia greater than 4-8 h per day that conception rate decline significantly (P<0.05).
This chart show changes in mean vaginal temperature of cooled and uncooled cows throughout the day.
Infertility of dairy cows under tropical conditions is primarily caused by elevated body temperature. Therefore, cooling cows should improve conception rates. A variety of cooling systems are available for heat-stressed cows. The intensive cooling cows with the combination of sprinklers and fans were used for improved reproductive performance. Cows were cooled in the holding area for a total 6-8 cooling periods and 4-6 cumulative h/day. Each cooling period combined cycles of sprinkling (0.5 min) and forced ventilation (4.5 min). Intensive cooling had significantly affected on decreased body temperature and allowed cows to maintain normal body temperature throughout the day [78]. In the same study, uncooled cows had high body temperature, daytime significant portion of the day and returned to normal body temperature during the late night and early morning (Figure 8).
This chart show conception rates obtained in uncooled cows during 2004-2007 and cooled cows during 2008-2011 on commercial dairy farm in the central part of Thailand.
For large scale survey was carried out during a 8 yr period (2004-2011) in commercial dairy farm. The conception rate of intensively cooled cows with sprinkler and forced ventilation was significantly higher than that of uncooled cows. Conception rates obtained in intensively cooled cows in this study were similar to those obtained in that same winter in uncooled cows (Figure 9). This current finding confirmed this adverse effect of heat stress. In hot climates there is a large decrease in the fertility of dairy cows during summer months. In addition, intensively cooling cows has the potential to eliminate the decline in conception rate of dairy cows under tropical conditions. Therefore, intensive cooling is essential in dairy cows under tropical conditions to prevent hyperthermia and its harmful effects on those cows.
The exposure of dairy cows to elevate temperatures have a variety of effects, including decreased fertility, depressed appetite, and decreased milk production, all of which contribute to the goal of decreasing the production of metabolic heat in order to maintain thermo-neutrality. This chapter showed significant advantages for the evaporative cooled barn can be used to reduce heat stress of dairy cows housed in hot and humid climates. The combined effect of higher milk production and increasing lactation persistency, with minimal costs could improve the financial status of dairy operations. The benefit demonstrated increased income over costs.
In addition, respiration rates and rectal temperatures, which affect both milk production and reproduction, were reduced by this environmental modification. These finding suggest that the evaporative cooling and tunnel ventilation system has the potential to decrease the exposure to heat stress, alleviate the symptoms of heat stress and improve milk production and metabolic efficiency during early lactation. This modification of the barn environment can reduce some of the detrimental effects of heat stress on follicular development and can improve the response rate to the synchronization of ovulation in dairy cows in hot and humid climates.
The implementation of evaporative cooling systems for dairy cows in hot and humid climates increased the percentage of cows that initially established a pregnancy and increased successful pregnancy while decreasing early embryonic mortality, if these cows were sufficiently cooled after breeding. It appears that modification of environment need to be developed further to improve reproductive performance of dairy cows in hot and humid climates. The finding that the cooling of cows did not alleviate all the effects of heat stress on pregnancy rates suggests that the degree of cooling was not sufficient to prevent the adverse effects of heat stress. It is also possible that the cooling of dairy cows needs to be done not only in the housing unit but also in the holding and milking areas to improve pregnancy rates. Dairy cows in hot and humid climatic condition need to be intensively cooled to completely eliminate heat stress to improve production and fertility close to normal. Therefore, additional research is needed to determine the effects of environmental modification or improved cooling system on postpartum reproductive performance and production when compared to conventional methods of cow cooling in the tropical area. However, cooling intensification should be combined with reproductive management, hormonal application and nutritional management to minimize the decline in cow performances under hot and humid climatic conditions.
This study was supported by the Thailand Research Fund and Faculty of Veterinary Science, Chulalongkorn University.
Despite the flexibility, such as agile (APMa), hybrid (HPMa), and extreme (EPMa), project management approaches come from the software project environment [16], and they are being increasingly used in nonsoftware environments as well. Flexible project management methods require flexible project scheduling methods, which allow flexible project structure [5]. Because of the time complexity, only a few methods handle the flexible nature of the projects. Nevertheless, in recent years, a new family of flexible scheduling methods [13] has been proposed. Instead of network-based methods, these algorithms are based on domain mapping (DMM) [4] and multidomain mapping matrices (MDMs) [1]. To support the agile project management approach, the proposed matrix-based methods handle both the priority of the task completions and the flexibility of dependencies between tasks [5, 8]. In addition to supporting extreme project management approaches, unplanned tasks can be scheduled [7]. The proposed matrix-based method can also be used to plan traditional, nonflexible projects. In this way, multimode completions can be specified. Nevertheless, the multimode and flexible project structures can also be combined to support hybrid project management approaches. The proposed flexible scheduling algorithms can be used not only in the projects but also at the project portfolio level [6].
The proposed matrix-based algorithm is based on the former studies [5, 6, 7, 8]; however, they are unified into the common matrix-based model, and they are extended to handle nonrenewable resources too. The proposed matrix-based model and the scheduling algorithm have the following features.
They handle fixed, but also
They handle planned, but also
They handle single, but
They can handle
They can model single, but also
In order to keep the adaptability of the proposed method, all features in italic style are optional. It means, when scheduling traditional project plans, there is no need to plan any supplementary tasks, flexible dependencies, or unplanned tasks; however, these features are optionally used in a flexible, such as agile, hybrid, or extreme project planning. Selecting from the multiple completion modes (called discrete technologies) is only relevant if there are more alternative technology. And last but not least, planning in a multilevel project environment is also an optional feature; however, it is crucial in the case of planning the resource sharing within the multi-projects.
In addition to the tasks, the risk effects of project scheduling can also be modeled [10]. The matrix-based risk evaluation has the following features:
Risk factors, risk effects, goals, and stakeholders can be modeled in a unified matrix-based model.
It handles independent, but also interdependent risk factors.
Both the planning and the tracking phases are covered.
All the proposed algorithms have software application support [9]. Therefore, after the model has been developed, the proposed methods can be compared. The MATLAB add-on [9] with examples guides users from the project planning to the risk evaluation.
The aim of this chapter is twofold. First, the chapter shows how to model flexible single and multilevel project plans and their risks. Second, the chapter summarizes the algorithms, so-called project management agents, that simulate a decision maker. In this way, the different project management approaches can compete, and the best one can be selected.
In terms of scheduling, a project is a set of tasks, which has to be solved,
within a time-frame (= time constraint,
within the budget (= cost constraint,
within the renewable/nonrenewable resources (
with adequate quality (
with adequate scope (
The fixed dependency between (successor and a predecessor) tasks specifies, that a successor task may start if the predecessor task has finished (sequential completion). While flexible dependency, based on a later decision either allows either a sequential or a parallel completion.
In terms of planning and scheduling, the multilevel project is the set of projects. Within a multilevel project, at least two overlapping projects specify a
Apart from network planning methods, matrix-based project planning is used to model complex project plans [2]. Matrix-based project planning methods are often based on the design (or dependency) structure matrix (DSM) [14]. The domain mapping matrix (DMM) is an extended version of the DSM, with multiple domains [4]. In this chapter, a modified project-oriented version of a domain mapping matrix (DMM) is used, which is called the project domain matrix (PDM) [5].
The PDM contains two mandatory and four supplementary domains.
The first mandatory domain is the logic domain. Diagonal values in
The additional supplementary domains are:
Table 1 shows an example of a fully filled PDM matrix. There are 3 (2 mandatory, 1 supplementary) tasks, 3 (2 fixed, 1 flexible) dependencies, 2 completion modes, 2 nonrenewable resources, and 3 renewable resources. The optional domains can be either ignored or filled out with zero values.
P D M | Logic domain | Time domain | Cost domain | Quality domain | Nonrenewable resource domain | Renewable resource domain | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | C | |||||||||||||||||
1 | 1 | .6 | 1 | 2 | 3 | 2 | .7 | .8 | 4 | 5 | 3 | 6 | 3 | 6 | 3 | 5 | 4 | 2 | |
0 | .7 | 1 | 2 | 2 | 4 | 3 | .8 | .9 | 3 | 3 | 4 | 4 | 4 | 7 | 4 | 6 | 4 | 3 | |
0 | 0 | 1 | 4 | 3 | 5 | 3 | .9 | .8 | 4 | 2 | 5 | 3 | 4 | 2 | 4 | 7 | 6 | 4 |
The structure of the project domain matrix.
Since PDM can model flexible dependencies and task priorities, it can be used to model both traditional and flexible approaches, such as agile and extreme approaches, and hybrid project planning approaches (see details in Section 3). Nevertheless, handling completion priorities and flexible dependencies alone raises the number of possible project plans.
The project can be organized into a multilevel project. The projects in the applied M
Matrix-based multimode multilevel (project) management model.
Because of the numerous possible project plans, there is no chance to compute all possible projects or multilevel project plans. A fast, exact method is required to find the best project or multilevel project structure.
After deciding which tasks are completed, which flexible dependency is required, and which completion mode is selected, we obtain a (multilevel) project plan. Table 3 shows, a single (a) and a multilevel (b) project schedule matrix (PSM).
Single and multilevel PSM.
Table 3(a) shows a project schedule matrix of PDM (see Table 1), which contains 6 domains. Table 3(b) shows a possible project schedule M
Previously, [16] found that in his study of the practices of software project managers, only 20% of IT projects were managed by a traditional project management (TPM) methodology. Generally, methods for investment and construction projects cannot be directly applied to software development or R&D projects, as these are managed by agile project management (APM) approaches. Currently, hybrid (i.e., combinations of traditional and agile and extreme) approaches are becoming increasingly popular [11]. However, flexible approaches are thus far not privileges for software development projects [15]. Rapidly changing environments increasingly enforce flexible approaches. Project planning and scheduling algorithms can support decision makers in managing projects; however, there are only a few algorithmic procedures that can support flexible approaches. Therefore, it is important to study how to extend project planning and scheduling methods to handle flexible and changing environments. Planning and scheduling methods, as agents, can also imitate decision makers; therefore, not only the methods but also the scheduling and project planning approaches can be modeled (see Table 4).
While, a project manager who follows a traditional project management (TPM) approach can use tradeoff or multimode methods to reduce task duration or cost/resource demands, an agile and extreme project manager tries to restructure the project. If the project structure is flexible (see Table 4), then the project duration can be reduced without increasing the project cost by reducing the number of flexible dependencies. In addition, in real project situations, decision makers can choose from different kinds of technologies (i.e. completion modes); therefore, the TPM and APM approaches can be integrated. Agile approaches usually split the projects into smaller so-called “sprints” that are usually 2−6 weeks. The content of sprints is specified by the customer and developers together. However, when running a sprint, unplanned new tasks and new requirements can be involved only until the next sprint. The extreme project management (EPM) approach handles the new tasks and new requirements during the implementation of the project. Extreme project management can confirm the extra costs and the increased project duration due to the extra tasks.
Flexible approaches require flexible project structures; however, in addition to the opportunity to reorganize the project, different kinds of technology (completion modes) should also be considered; therefore, traditional and flexible approaches should be combined into hybrid project management approaches [11, 12, 15]. Nevertheless, hybrid approaches should be supported by algorithmic methods to help decision makers ensure the project’s success.
There are different combinations of agile and traditional project management approaches [11, 12, 15]. However, there are very few exact algorithms (see, e.g., [7, 8]) that can be used to solve hybrid multimode problems that can handle unplanned tasks and dependencies. Nevertheless, R&D and IT projects, such as introducing and setting up new information systems, may require reorganizing part of the project, and R&D projects may require handling unplanned tasks, particularly in the development phase. However, decreasing the time demands of mandatory tasks and those of the new unplanned tasks may also be an important requirement. Neither the agile approach, nor the extreme approach can handle this situation properly, nor can traditional approaches. Traditional approaches, or network-based methods, assume static logic plans, but the reorganization of projects may produce insufficient reductions in project duration and/or supplementary tasks, and important tasks may be excluded from the project due to budget constraints and/or project deadlines. A hybrid project management (HPM) approach can combine traditional, agile, and extreme approaches; however, these kinds of HPM approaches are not yet supported by project planning methods. The proposed algorithm combines agile, extreme, and traditional approaches. This method extends the traditional multi-mode resource-constrained project scheduling problem by allowing for the restructuring and reorganizing of projects and handling of unplanned new tasks.
The proposed hybrid time–cost and hybrid time-quality-cost tradeoff models [8] and multimode methods [7] manage flexible project plans and allow us to restructure or reorganize these project plans to satisfy customer and management claims. In contrast to the traditional project scoring and selection methods, there is no need to specify all project alternatives to select the most desirable project scenario or the one with the shortest duration or lowest cost. The following definition specifies a matrix representation of a flexible (multilevel) project plan and its possible realization.
Definition 1 proposes a unified matrix-based model, both for single and multilevel project plans, and both for single and multimode completions. In addition, by increasing
where
It is important to note that the relative constraint should be within the [0,1] interval (
(
Either simple or composite target functions can be specified both for single and multilevel projects.
Simple target functions:
where
The composite target function handles all possible targets with their importance:
where
Due to the size constraints, only the main feature of the proposed algorithm is summarized. See the details in [6, 8].
The evaluation contains three steps.
First, the diagonal values of the
In the second step, all flexible tasks (
In the third step, all completion modes are evaluated. For every task, a completion mode is selected.
For every kind of multilevel project plan, the minimal (maximal) demands can be specified without calculating all possible solutions.
If all supplementary tasks are excluded (included), the
If all supplementary tasks are excluded (included), and all completion modes require minimal (maximal) demands,
If all supplementary tasks are excluded (included), and all dependencies are excluded (included) and all completion modes require minimal (maximal) demands,
If all supplementary tasks are excluded (included), but all dependencies are included (excluded) and all completion modes require minimal (maximal) demands,
Due to the evaluation, if the minimal (maximal) demands are greater (lower) than the constraint, neither the project plan nor their derived plans are feasible.
Based on these properties, exact back and forth algorithms are proposed to find a single project schedule [7] or multilevel project structure [6]. All methods contain three phases. In the first phase, binary decisions select supplementary tasks to include the project plan. The excluded tasks’ demands and dependencies (i.e., rows and columns in the PDM) are also ignored. The result is a
Table 5 shows an example for the computation process of a single project, where the target function is the minimal project duration. Task E is unplanned, which means, the constraints are specified before task E occurs. Table 5(a) shows the original project plan, where there are 3 completion modes, 2 renewable resources, cost demands, and quality parameters. There is no nonrenewable resource, however, the cost demand can be considered as a special nonrenewable resource. While keeping constraints, the algorithm has to find a minimal project duration.
Planning approaches | Features | |||
---|---|---|---|---|
Project structure | New tasks | Multimode | Constraints | |
Traditional (TPM) | Fixed | Not allowed | Handled | Fixed |
Agile (APM) | Flexible | Not allowed | Not handled | Fixed |
Extreme (EPM) | Flexible | Allowed | Not handled | Flexible |
Hybrid (HPM) | Flexible | Allowed | Handled | Optional |
Comparison of the traditional and flexible approaches.
The phases of the computation.
The minimal TPT occurs if all flexible tasks and dependencies are excluded, however, neither the scope nor the quality constraint does not allow to exclude all tasks (see Table 5(b)), but only task D. In addition, all flexible dependencies cannot be excluded. For example, in the case of the parallel execution of task A and task C, the resource constraint cannot be kept (see Table 5(c)). The algorithm excludes the infeasible structures in phases 1−2. The result of phase 2 provides a multimode resource-constrained project scheduling problem, which can be solved by traditional scheduling algorithms. The final result is a project schedule matrix (PSM) (see Table 5(d)), where both the structure of the project plan and its demands are specified (see Table 5(e)).
Kosztyán et al. [10] proposed a flexible matrix-based method for risk evaluation for single projects, where all the
The proposed survival analysis-based risk evaluation (SABER) contains three stages (or phases). In all phases, the feasibility of the projects is checked.
Since before starting projects, the boundary conditions of the project are agreed upon, at
At stage two, a two-step Monte Carlo Analysis (MCA) is applied. In the first step, the set of tasks and the relationship of risk factors are selected, while in the second step, the changes in demands and priorities are changed for the selected tasks.
At
Figure 1 shows the simulation framework of the SABER.
The simulation framework.
The simulation framework indicates, which project plans survive. It shows the performances of applied agents and sensitivities of risk effects, and in addition, the interdependency of risk factors and risk effects, see in detail in [10].
There are free available matrix-based project planning tools for flexible projects [9]. This plug-in can be applied both for project planning and for risk evaluation. It contains 5 domains, such as LD, TD, CD, QD, and RD. It solves several project scheduling problems (PSPs) for flexible projects, such as Pareto-optimal (multimode) resource-constrained PSPs for a single target function and their Pareto-optimal solutions for multiple targets.
The application example guides us through matrix-based planning and risk evaluation phases.
The first step is to specify a matrix-based project plan. It can come from the original network-based project plan, but it can be generated. In this case, at least the number of tasks, number of modes, and number of resources have to be specified.
Figure 2(a) shows the logic structure of the flexible project plan. The minimal structures and their demands contain only mandatory tasks and fixed dependencies, while the maximal structure and its demands save all tasks and dependencies, and therefore, all demands. Figure 2 shows the minimal/maximal demands.
Minimal/maximal structures and demands (the number of tasks was 30, and the number of completion modes and the number of renewable resources was 2).
Figure 2 shows that there are significant differences between the minimal and maximal structures and their demands. Flexible and hybrid approaches can reorganize project structures and reprioritize task completion to save the project plan as feasible. Figure 3(a) shows the result project structures of the project management approaches. Figure 3(b) compares the project demands. The target function was the minimal distance from the minimal demands, while the constraint was 2/3 of the maximal demands. The vertical axis of 3(b) is the performance (
The comparison of project management approaches.
If
Figure 3 shows that the flexible and hybrid project management approaches try to parallelize task completions and exclude low priority tasks, while TPMa tries to reduce demands but keeps all tasks.
Figure 4 shows the comparison of scheduling performances of the project management approaches under risks. Figure 4 shows that in this case, only the HPMa ensures the survival of the project plan.
The scheduling performances of project management approaches under risks.
In this chapter, matrix-based approaches are proposed to schedule traditional, flexible, and hybrid project plans. In addition, a risk evaluation tool is proposed to compare project management approaches. It is important to note that there is usually no superior project management approach. If the goal is to complete all tasks, traditional approaches are required; however, flexible projects require flexible project management approaches. Nevertheless, hybrid approaches can better ensure the survival of the project. The study also offers freely available matrix-based project planning applications; therefore, all traditional, flexible, and hybrid project management, planning and scheduling approaches can be supported.
The authors declare no conflict of interest.
CD | cost domain |
LD | logic domain |
ND | nonrenewable resource domain |
QD | quality domain |
RD | renewable resource domain |
TD | time domain |
n | number of tasks |
m | number of completion modes |
p | number of projects |
η | number of nonrenewable resources |
ρ | number of renewable resources |
τ | actual time of a running project |
Ct | time constraint (upper bound, scalar) |
Cc | cost constraint (upper bound, scalar) |
Cq | quality constraint (lower bound, scalar) |
Cn | nonrenewable resource constraint (upper bound, 1 by η vector) |
Cr | renewable resource constraint (upper bound, 1 by ρ vector) |
Cs | score/scope constraint (lower bound, scalar) |
TPT→min | minimize project duration |
TPC→min | minimize project cost |
TPQ→max | maximize project quality |
TPNe→min | minimize the sum of nonrenewable resources e, e=1,..,η |
TPRr→min | minimize the maximum of renewable resources r, r=1,..,ρ |
TPS→max | maximize project score/scope |
APM(a) | agile project management (agent) |
DMM | domain mapping matrix |
DSM | design/dependency structure matrix |
EF | early/earliest finish time |
EPM(a) | extreme project management (agent) |
ES | early/earliest start time |
HPM(a) | hybrid project management (agent) |
LF | late/latest finish time |
LS | late/latest start time |
M5 | matrix-based multimode multilevel (project) management model |
MCA | Monte Carlo analysis [MDM] multidomain matrix |
MPE | reverse extreme project management |
MPR | multilevel project ranking algorithm |
NDSM | numerical dependency structure matrix |
PDM | project domain matrix |
PSP | project scheduling problem |
PSM | project schedule matrix |
SABER | survival analysis-based risk evaluation |
SF | scheduled finish time |
SS | scheduled start time |
TPC | total project cost |
TPM(a) | traditional project management (agent) |
TPN | total project nonrenewable resources |
TPQ | total project quality |
TPR | total project renewable resources |
TPS | total project scenario score |
TPT | total project time |
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As many patients retain good neurologic function, the approach to their management has shifted markedly; a pre-terminal prognosis and palliative treatment have been replaced by individualized care plans to prolong functional survival. However, the rapid shifts in disease characteristics, treatment options and emerging evidence can be challenging to navigate, and a rational approach to brain metastases is needed. We discuss the changing epidemiology of brain metastases and consider approaches to prognostic classification. We review current treatment modalities and discuss the significant studies pertaining to each, with emphasis on Level 1 evidence when available and cooperative group trials, as well as studies on adverse effects. To integrate the information presented, we offer case scenarios that highlight pertinent decision-making factors. The shift in care goal for cerebral metastases from symptom palliation to prolongation of survival is not only feasible, but in many cases indicated. The appropriate application of various treatment modalities must be considered in the context of individual patients and their primary cancer.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Karolyn Au, Ying Meng, Suganth Suppiah, Anick Nater, Rakesh\nJalali and Gelareh Zadeh",authors:[{id:"194279",title:"M.D.",name:"Karolyn",middleName:null,surname:"Au",slug:"karolyn-au",fullName:"Karolyn Au"},{id:"197665",title:"Dr.",name:"Ying",middleName:null,surname:"Meng",slug:"ying-meng",fullName:"Ying Meng"},{id:"197666",title:"Dr.",name:"Suganth",middleName:null,surname:"Suppiah",slug:"suganth-suppiah",fullName:"Suganth Suppiah"},{id:"197667",title:"Dr.",name:"Anick",middleName:null,surname:"Nater",slug:"anick-nater",fullName:"Anick Nater"},{id:"197668",title:"Dr.",name:"Gelareh",middleName:null,surname:"Zadeh",slug:"gelareh-zadeh",fullName:"Gelareh Zadeh"},{id:"197669",title:"Dr.",name:"Rakesh",middleName:null,surname:"Jalali",slug:"rakesh-jalali",fullName:"Rakesh Jalali"}]},{id:"53003",doi:"10.5772/66131",title:"Managing CNS Tumors: The Nanomedicine Approach",slug:"managing-cns-tumors-the-nanomedicine-approach",totalDownloads:1175,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Albeit the rapidly evolving knowledge about tumor biochemistry enables various new drug molecules to be designed as treatments, malignant central nervous system (CNS) tumors remain untreatable due to the failure to expose the entire tumor to such therapeutics at pharmacologically meaningful quantities. Therefore, drug delivery in CNS tumors must be properly addressed, as otherwise, novel therapies will continue to fail. In this regard, nanomedicine poses an appealing platform for efficient drug delivery to the CNS, since it may be targeted to improve the drug availability in the site of action, which would be translated into lower drug doses and fewer side effects. Hence, the accumulation of data about the CNS physiology and their relevant receptors, the widening therapeutic armamentarium of drugs potentially useful in CNS chemotherapy and the alternative routes for administration may envisage nanomedicines as a forthcoming routine approach. Indeed, on the basis of the promising results gathered from preclinical studies of nanomedicine-based therapy both systemically and locally administered, some nanomedicines have already been approved for clinical trials in a variety of CNS tumor conditions to serve as the first steps in the translation of nanotherapy to clinic. Their outcome will steer research directions for further improvements.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Juan Aparicio-Blanco and Ana-Isabel Torres-Suárez",authors:[{id:"193558",title:"Prof.",name:"Ana Isabel",middleName:null,surname:"Torres-Suárez",slug:"ana-isabel-torres-suarez",fullName:"Ana Isabel Torres-Suárez"},{id:"195630",title:"MSc.",name:"Juan",middleName:null,surname:"Aparicio-Blanco",slug:"juan-aparicio-blanco",fullName:"Juan Aparicio-Blanco"}]},{id:"54440",doi:"10.5772/67591",title:"NeuroPharmacology: As Applied to Designing New Chemotherapeutic Agents",slug:"neuropharmacology-as-applied-to-designing-new-chemotherapeutic-agents",totalDownloads:1212,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Neurooncology anticancer drugs are no exception—their distribution and tissue interactions follow the general rules of classical pharmacology. In an attempt to assist with the new therapeutic approaches to manage cancers involving the central nervous system, classical chemobiodynamic compartment and pharmacokinetic models are discussed and illustrated. In addition, strategies and approaches for penetrating the blood brain barrier (BBB) are reviewed and modeled. Finally, in support of classical pharmacology, a new anticancer agent in clinical trial for brain tumors is reviewed as an example of clinical onco-neuropharmacology.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Andrew H. Rodgers and Lee Roy Morgan",authors:[{id:"158053",title:"Dr.",name:"Lee Roy",middleName:null,surname:"Morgan",slug:"lee-roy-morgan",fullName:"Lee Roy Morgan"},{id:"193557",title:"Ph.D.",name:"Andrew",middleName:null,surname:"Rodgers",slug:"andrew-rodgers",fullName:"Andrew Rodgers"}]},{id:"53265",doi:"10.5772/66304",title:"Comparative Anticancer Activity in Human Tumor Xenograft Models, Preclinical Pharmacology and Toxicology for 4- Hydroperoxyifosfamide (HOOI): A Potential Neuro-Alkylating Agent for Primary and Metastatic Cancers Involving the Central Nervous System",slug:"comparative-anticancer-activity-in-human-tumor-xenograft-models-preclinical-pharmacology-and-toxicol",totalDownloads:794,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Background: 4-Hydropeoxyifosfamide (HOOI) is a hydroperoxy derivative of ifosfamide that was developed as an anticancer agent that can penetrate the blood-brain barrier (BBB), which can be potentially useful in the management of brain tumors.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Lee Roy Morgan, Andrew H. Rodgers, Gerard Bastian, William S.\nWaud, Branko S. Jursic, Robert F. Struck, Gerald LaHoste and\nEdward Stevens",authors:[{id:"158053",title:"Dr.",name:"Lee Roy",middleName:null,surname:"Morgan",slug:"lee-roy-morgan",fullName:"Lee Roy Morgan"}]},{id:"53368",doi:"10.5772/65791",title:"Advances in the Treatment of Primary Brain Tumors: The Realm of Immunotherapy",slug:"advances-in-the-treatment-of-primary-brain-tumors-the-realm-of-immunotherapy",totalDownloads:1063,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Central nervous system (CNS) tumors, although rare, represent a group of neoplasms that have a disproportionate morbidity and mortality. Despite advances in our understanding of tumor pathogenesis coupled with improvements in therapeutic options, overall survival for primary brain tumors remains dismal. Although challenging, newer approaches such as brachytherapy, immunotherapy, and electric field generators are currently being evaluated in the clinical setting with promising results. The field of immunotherapy in neurooncology is still in its infancy, but several advances have already been made, including the development of tumor vaccines, utilization of immune checkpoint inhibitors, and activation of tumor dendritic cells to stimulate the host’s immune system. Recent advances in noninvasive electric fields have been applied to the treatment of glioblastoma multiforme (GBM) with encouraging clinical outcome. In this chapter, we will review the latest advances in the treatment of glioblastoma multiforme with a focus on immunotherapy.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Michael J. Strong and Marcus L. Ware",authors:[{id:"193518",title:"Mr.",name:"Michael",middleName:null,surname:"Strong",slug:"michael-strong",fullName:"Michael Strong"},{id:"193559",title:"Dr.",name:"Marcus",middleName:null,surname:"Ware",slug:"marcus-ware",fullName:"Marcus Ware"}]}],mostDownloadedChaptersLast30Days:[{id:"53170",title:"Current Management of Brain Metastases: Overview and Teaching Cases",slug:"current-management-of-brain-metastases-overview-and-teaching-cases",totalDownloads:1624,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Over the past two decades, increased global incidence of malignancy, improved systemic disease treatment with prolonged survival, and increased central nervous system (CNS) surveillance in cancer patients have all contributed to a rise in cerebral metastatic disease. As many patients retain good neurologic function, the approach to their management has shifted markedly; a pre-terminal prognosis and palliative treatment have been replaced by individualized care plans to prolong functional survival. However, the rapid shifts in disease characteristics, treatment options and emerging evidence can be challenging to navigate, and a rational approach to brain metastases is needed. We discuss the changing epidemiology of brain metastases and consider approaches to prognostic classification. We review current treatment modalities and discuss the significant studies pertaining to each, with emphasis on Level 1 evidence when available and cooperative group trials, as well as studies on adverse effects. To integrate the information presented, we offer case scenarios that highlight pertinent decision-making factors. The shift in care goal for cerebral metastases from symptom palliation to prolongation of survival is not only feasible, but in many cases indicated. The appropriate application of various treatment modalities must be considered in the context of individual patients and their primary cancer.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Karolyn Au, Ying Meng, Suganth Suppiah, Anick Nater, Rakesh\nJalali and Gelareh Zadeh",authors:[{id:"194279",title:"M.D.",name:"Karolyn",middleName:null,surname:"Au",slug:"karolyn-au",fullName:"Karolyn Au"},{id:"197665",title:"Dr.",name:"Ying",middleName:null,surname:"Meng",slug:"ying-meng",fullName:"Ying Meng"},{id:"197666",title:"Dr.",name:"Suganth",middleName:null,surname:"Suppiah",slug:"suganth-suppiah",fullName:"Suganth Suppiah"},{id:"197667",title:"Dr.",name:"Anick",middleName:null,surname:"Nater",slug:"anick-nater",fullName:"Anick Nater"},{id:"197668",title:"Dr.",name:"Gelareh",middleName:null,surname:"Zadeh",slug:"gelareh-zadeh",fullName:"Gelareh Zadeh"},{id:"197669",title:"Dr.",name:"Rakesh",middleName:null,surname:"Jalali",slug:"rakesh-jalali",fullName:"Rakesh Jalali"}]},{id:"53032",title:"Role of Pathologist in Driver of Treatment of CNS Tumors",slug:"role-of-pathologist-in-driver-of-treatment-of-cns-tumors",totalDownloads:1584,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The incidence of Central Nervous System (CNS) tumors is gradually increasing. Furthermore, metastatic neoplasms are frequently seen in neuropathology practice as a major cause of mortality and morbidity. Pathologists try to reach a more accurate diagnosis by mentally filtering a synthesis, comprising age, radiological characteristics and microscopic findings in the sample sent, starting already from the intraoperative diagnosis process. By displaying their skills, they unveil whether a lesion in the brain parenchyma is a normal or reactive tumor and if this is a tumor, is it primary or metastatic, and if it is primary, what is the tumor type or if it is metastatic, which organ could it be associated with. Pathologists use diagnostic, prognostic and predictive markers in order to enable the patient receive the most effective and sufficient treatment. They ensure that an individualized treatment is provided via these tools, by making a histological diagnosis of the lesion according to the WHO classification, identifying the course of the disease and preventing undesired and dangerous complications. This chapter will focus on answering these questions and share the value of a multidisciplinary approach in the management of brain tumors in neurosciences, which is gradually increasing in importance, and how pathologists execute this art.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Serdar Altınay",authors:[{id:"185324",title:"Associate Prof.",name:"Serdar",middleName:null,surname:"Altınay",slug:"serdar-altinay",fullName:"Serdar Altınay"}]},{id:"53873",title:"Primary Central Nervous System Lymphoma",slug:"primary-central-nervous-system-lymphoma-2017-03",totalDownloads:1682,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Although non-Hodgkin’s lymphoma (NHL) is a frequent cancer worldwide, primary central nervous system (CNS) lymphoma (PCNSL) is a rare presentation, with an incidence of less than 0.5 per 100,000 persons-years in the western world. In the vast majority of cases, it has the histology of a diffuse large B-cell lymphoma (DLBCL) and is a hardly curable disease with high relapse risk. Therapeutic options are limited by blood-brain barrier penetration of drugs and because of its low-incidence high-grade evidence from large studies is lacking, current management being based on reports on rather small cohorts. The current standard first-line treatment for PCNSL consists of high-dose methotrexate (HD-MTX) in combination with a variety of drugs and consolidation whole-brain radiotherapy, the latter being progressively replaced by chemotherapy. For patients relapsing after first-line treatment, intensive chemotherapy with autologous stem cell support is a feasible and relatively safe salvage therapy. In the present chapter, we briefly discuss primary central nervous system lymphoma management and review current therapeutic options and evidence-based recommendations. We discuss the role of whole-brain radiotherapy (WBRT) and new prospects to avoid this side effect-ridden approach. Also, we will look at new therapeutic approaches currently under investigation, including immunotherapy.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Mihnea Zdrenghea, Delia Dima, Ciprian Tomuleasa, Horia Bumbea\nand Cristina Bagacean",authors:[{id:"73222",title:"Dr.",name:"Delia",middleName:null,surname:"Dima",slug:"delia-dima",fullName:"Delia Dima"},{id:"193180",title:"Dr.",name:"Mihnea",middleName:null,surname:"Zdrenghea",slug:"mihnea-zdrenghea",fullName:"Mihnea Zdrenghea"},{id:"198423",title:"Dr.",name:"Cristina",middleName:null,surname:"Bagacean",slug:"cristina-bagacean",fullName:"Cristina Bagacean"}]},{id:"53003",title:"Managing CNS Tumors: The Nanomedicine Approach",slug:"managing-cns-tumors-the-nanomedicine-approach",totalDownloads:1175,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Albeit the rapidly evolving knowledge about tumor biochemistry enables various new drug molecules to be designed as treatments, malignant central nervous system (CNS) tumors remain untreatable due to the failure to expose the entire tumor to such therapeutics at pharmacologically meaningful quantities. Therefore, drug delivery in CNS tumors must be properly addressed, as otherwise, novel therapies will continue to fail. In this regard, nanomedicine poses an appealing platform for efficient drug delivery to the CNS, since it may be targeted to improve the drug availability in the site of action, which would be translated into lower drug doses and fewer side effects. Hence, the accumulation of data about the CNS physiology and their relevant receptors, the widening therapeutic armamentarium of drugs potentially useful in CNS chemotherapy and the alternative routes for administration may envisage nanomedicines as a forthcoming routine approach. Indeed, on the basis of the promising results gathered from preclinical studies of nanomedicine-based therapy both systemically and locally administered, some nanomedicines have already been approved for clinical trials in a variety of CNS tumor conditions to serve as the first steps in the translation of nanotherapy to clinic. Their outcome will steer research directions for further improvements.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Juan Aparicio-Blanco and Ana-Isabel Torres-Suárez",authors:[{id:"193558",title:"Prof.",name:"Ana Isabel",middleName:null,surname:"Torres-Suárez",slug:"ana-isabel-torres-suarez",fullName:"Ana Isabel Torres-Suárez"},{id:"195630",title:"MSc.",name:"Juan",middleName:null,surname:"Aparicio-Blanco",slug:"juan-aparicio-blanco",fullName:"Juan Aparicio-Blanco"}]},{id:"54440",title:"NeuroPharmacology: As Applied to Designing New Chemotherapeutic Agents",slug:"neuropharmacology-as-applied-to-designing-new-chemotherapeutic-agents",totalDownloads:1212,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Neurooncology anticancer drugs are no exception—their distribution and tissue interactions follow the general rules of classical pharmacology. In an attempt to assist with the new therapeutic approaches to manage cancers involving the central nervous system, classical chemobiodynamic compartment and pharmacokinetic models are discussed and illustrated. In addition, strategies and approaches for penetrating the blood brain barrier (BBB) are reviewed and modeled. Finally, in support of classical pharmacology, a new anticancer agent in clinical trial for brain tumors is reviewed as an example of clinical onco-neuropharmacology.",book:{id:"5599",slug:"new-approaches-to-the-management-of-primary-and-secondary-cns-tumors",title:"New Approaches to the Management of Primary and Secondary CNS Tumors",fullTitle:"New Approaches to the Management of Primary and Secondary CNS Tumors"},signatures:"Andrew H. Rodgers and Lee Roy Morgan",authors:[{id:"158053",title:"Dr.",name:"Lee Roy",middleName:null,surname:"Morgan",slug:"lee-roy-morgan",fullName:"Lee Roy Morgan"},{id:"193557",title:"Ph.D.",name:"Andrew",middleName:null,surname:"Rodgers",slug:"andrew-rodgers",fullName:"Andrew Rodgers"}]}],onlineFirstChaptersFilter:{topicId:"1086",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. 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In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:48,paginationItems:[{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. 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It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. 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We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Artificial Intelligence",id:"14"},selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. 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Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. 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