Connectivity measures in Preston’s local food system.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"956",leadTitle:null,fullTitle:"Cystic Fibrosis - Renewed Hopes Through Research",title:"Cystic Fibrosis",subtitle:"Renewed Hopes Through Research",reviewType:"peer-reviewed",abstract:"Living healthy is all one wants, but the genetics behind creation of every human is different. As a curse or human agony, some are born with congenital defects in their menu of the genome. Just one has to live with that! The complexity of cystic fibrosis condition, which is rather a slow-killer, affects various organ systems of the human body complicating further with secondary infections. That's what makes the disease so puzzling for which scientists around the world are trying to understand better and to find a cure. Though they narrowed down to a single target gene, the tentacles of the disease reach many unknown corners of the human body. Decades of scientific research in the field of chronic illnesses like this one surely increased the level of life expectancy. This book is the compilation of interesting chapters contributed by eminent interdisciplinary scientists around the world trying to make the life of cystic fibrosis patients better.",isbn:null,printIsbn:"978-953-51-0287-8",pdfIsbn:"978-953-51-6898-0",doi:"10.5772/1463",price:159,priceEur:175,priceUsd:205,slug:"cystic-fibrosis-renewed-hopes-through-research",numberOfPages:564,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"703f0969078948d82535b7b0c08ab613",bookSignature:"Dinesh Sriramulu",publishedDate:"March 28th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/956.jpg",numberOfDownloads:81813,numberOfWosCitations:54,numberOfCrossrefCitations:17,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:53,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:124,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 8th 2011",dateEndSecondStepPublish:"April 5th 2011",dateEndThirdStepPublish:"August 10th 2011",dateEndFourthStepPublish:"September 9th 2011",dateEndFifthStepPublish:"January 7th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"91317",title:"Dr.",name:"Dinesh",middleName:null,surname:"Sriramulu",slug:"dinesh-sriramulu",fullName:"Dinesh Sriramulu",profilePictureURL:"https://mts.intechopen.com/storage/users/91317/images/system/91317.jpg",biography:"Dinesh Sriramulu, graduated from the Technical University of Braunschweig, Germany with his doctorate degree in Medical Microbiology. He started his research career at the Helmholtz Centre for Infection Research, Braunschweig, Germany in collaboration with the Karolinska Institutet, Stockholm, Sweden. His area of expertise is on the adaptation of bacteria towards diverse niches, ranging from the human lung to the cattle rumen. He also worked on tumor microenvironment in the case of esophageal and breast cancers. He continued his research work at various reputed institutions worldwide: University College Cork, Ireland; University of Medicine and Dentistry – New Jersey, USA; Food and Drug Administration, Rockville, USA; University of Southern California, Los Angeles, USA; University of Trento, Italy; and University of Cape Town, South Africa. He has published his research findings in various international peer-reviewed journals and presented his works at international conferences. He has been serving as editorial board member, peer-reviewer and as expert referee for scientific journals and research funding agencies. As a law graduate, he is also practicing law at the Hon’ble High Court of Madras, India.",institutionString:"Shres Consultany",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Helmholtz Centre for Infection Research",institutionURL:null,country:{name:"Germany"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1047",title:"Pulmonology",slug:"pulmonology"}],chapters:[{id:"34275",title:"The Prognosis of Cystic Fibrosis - A Clinician's Perspective",doi:"10.5772/30660",slug:"the-prognosis-of-cystic-fibrosis-a-clinician-s-perspective",totalDownloads:8275,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Patrick Lebecque",downloadPdfUrl:"/chapter/pdf-download/34275",previewPdfUrl:"/chapter/pdf-preview/34275",authors:[{id:"83586",title:"Prof.",name:"Patrick",surname:"Lebecque",slug:"patrick-lebecque",fullName:"Patrick Lebecque"}],corrections:null},{id:"34276",title:"Radiological Features of Cystic Fibrosis",doi:"10.5772/29614",slug:"radiological-features-of-cystic-fibrosis",totalDownloads:6971,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Iara Maria Sequeiros and Nabil A. 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However, the mechanisms by which specific HLA class II molecules control the immune response in autoimmune diseases have been unclear. On the other hand, autoantibodies are produced in most autoimmune diseases and cause clinical manifestations of the diseases. It has also been an enigma how autoantibodies targeting self-antigens cause the autoimmune diseases. Arase
This review will focus on the autoantibodies associating with the novel function of HLA class II molecules and the pathogenesis of antiphospholipid syndrome (APS).
The classical function of HLA class II molecules is to present antigen peptides, derived from exogeneous proteins digested in lysosomes, to helper T-cells and by that to activate them.
Endogenous proteins, on the other hand, are formed and folded in the endoplasmic reticulum (ER). Correctly folded proteins are essential for cell survival and function. Therefore, it is believed that misfolded proteins generated in the ER are never transported to the extracellular space, because such proteins are eliminated by ER-associated degradation (ERAD).
However, Arase
In addition, misfolded proteins complexed with HLA class II molecules of disease-susceptible alleles have been found to serve as targets of autoantibodies in certain autoimmune diseases, and to be involved in the disease pathogenesis. For example, immunoglobulin (Ig) G heavy chain complexed with HLA-DR and myeloperoxidase complexed with HLA-DR are major targets for autoantibodies in patients with rheumatoid arthritis and microscopic polyangiitis, respectively [3, 5].
APS is diagnosed both by the presence of clinical manifestations, including vascular thrombosis and pregnancy morbidity, and by the presence of antiphospholipid antibodies (aPLs) which present a laboratory criteria for APS [6]. Laboratory criteria for APS include IgG and IgM anticardiolipin antibodies (aCLs), IgG and IgM anti-β2-glycoprotein I (aβ2GPI) antibodies, and lupus anticoagulant (LAC). aPLs are thought to recognize linear β2-glycoprotein I (β2GPI), which undergoes conformational changes from the circular form of β2GPI by binding to negatively charged phospholipids [7], and cause APS by interacting with vascular endothelial cells [8]. Therefore, β2GPI bound to negatively charged phospholipids or negatively charged plates is used clinically to detect autoantibodies in APS patients [9]. However, because autoantibodies against the β2GPI complexed to negatively charged phospholipids or high binding plates are detected in less than half of patients with clinical manifestations of APS [10, 11, 12], these facts suggest that additional targets of autoantibodies may exist. Furthermore, because β2GPI is a secreted protein, it cannot be universally present on the cell surface. Therefore, there might be other specific molecules which present β2GPI on the surface of vascular endothelial cells.
We found that 293 T cells co-transfected with β2GPI and HLA-DR expressed both β2GPI and HLA-DR on the cell surface by flow cytometry analysis (Figure 1) [4]. Conversely, 293 T cells transfected with only β2GPI did not express β2GPI on the cell surface, because β2GPI is a secreted protein (Figure 1) [4]. Immunoprecipitation and immunoblotting experiments revealed that full-length β2GPI proteins, but not peptide fragments of β2GPI, formed a complex with HLA-DR, and that these full-length β2GPI/HLA-DR complexes were present on the cell surface [4].
Monoclonal anti-phospholipid antibody binds to β2GPI/HLA-DR complex on the cell surface. 293 T cells transfected with only β2GPI did not express β2GPI on the cell surface, and human monoclonal anti-phospholipid antibody (EY2C9) did not bind to these cells (the upper 3 histograms and 1 scheme). When β2GPI was co-transfected with HLA-DR into 293 T cells, β2GPI was expressed on the cell surface and was recognized by EY2C9 monoclonal antibody (the lower 3 histograms and 1 scheme). Abbreviations: HLA, human leukocyte antigen; β2GPI, β2-glycoprotein I; aPL mAb, anti-phospholipid monoclonal antibody.
Furthermore, flow cytometry analysis revealed that not only the monoclonal antiphospholipid antibody derived from an APS patient (EY2C9), but also antibodies in the sera of APS patients can bind to the β2GPI/HLA-DR complexes, even in the absence of phospholipids [4].
Immunofluorescence staining and
In addition, we found that monoclonal antibody EY2C9 exhibited complement-mediated cytotoxicity against 293 T cells expressing β2GPI together with the APS susceptibility allele HLA-DR7, however the cytotoxicity was not detected against 293 T cells expressing HLA-DR7 alone or against those transfected with β2GPI alone [4].
HLA class II expression on endothelial cells is known to be induced after exposure to cytokines, such as IFN-γ and TNF-α [14]. Therefore, inflammatory stimuli can induce HLA class II expression on vascular endothelial cells, and HLA class II molecules transport structurally altered β2GPI, which has high affinity for the peptide-binding grooves of the alleles of HLA class II. Autoantibodies against β2GPI/HLA class II complexes may damage vascular endothelial cells expressing β2GPI/HLA class II complexes in a complement-dependent manner and cause clinical manifestations of APS, including vascular thrombosis and pregnancy complications. In this way, β2GPI/HLA class II complexes and autoantibodies against the complexes may be involved in the pathogenesis of APS.
HLA-DR4, HLA-DR7, and HLA-DR13 have been reported as susceptibility alleles for APS [15, 16, 17, 18]. However, the mechanism by which these HLA class II alleles increase susceptibility to APS has remained an enigma.
To address this issue, we analyzed the ability of different HLA-DR alleles to transport β2GPI to the cell surface and found that HLA-DR7 and HLA-DR4 could transport much higher levels of β2GPI than other HLA-DR alleles recognized by the EY2C9 monoclonal antibody [4]. These results indicated that a binding affinity of β2GPI to each HLA-DR allele is important for autoantibody recognition of β2GPI/HLA-DR complexes and is associated with differences in susceptibility to APS between different HLA-DR alleles.
We developed and modified a method to measure serum levels of autoantibodies against β2GPI/HLA-DR complexes (anti-β2GPI/HLA-DR) [4, 19].
Green fluorescent protein (GFP)-labeled β2GPI/HLA-DR complex-expressing 293 T cells and DsRed-labeled HLA-DR-expressing 293 T cells were generated by transient transfection [19]. A serum sample from a patient in whom anti-β2GPI/HLA-DR were detectable after a 106-fold dilution was used as a standard serum. The anti-β2GPI/HLA-DR level of a standard serum was defined as 1,000 units. The mean fluorescence intensity (MFI) of IgG binding to transfected cells in the sample sera was analyzed by flow cytometry. Specific IgG binding to the β2GPI/HLA-DR complex was calculated by subtracting the MFI of IgG binding to HLA-DR-expressing cells from β2GPI/HLA-DR complex-expressing cells. Serum levels of anti-β2GPI/HLA-DR in each sample were calculated from the standard curve generated by measuring specific IgG binding to the β2GPI/HLA-DR complex in serially diluted standard serum.
In our previous study, we measured serum levels of anti-β2GPI/HLA-DR in stored sera from 120 patients with APS, most of whom had a history of vascular thrombosis, and found that 83% of the 120 patients had autoantibodies directed against β2GPI/HLA-DR complexes. Furthermore, about 50% of the APS patients who tested positive for anti-β2GPI/HLA-DR (< 99th percentile values measured in sera of 100 healthy subjects) were negative for both IgG aCLs and IgG aβ2GPI antibodies [4]. Another recent study also showed that 27% of 111 patients with idiopathic chronic limb ulcers who were negative for aPLs possessed anti-β2GPI/HLA-DR [20]. These results suggest that anti-β2GPI/HLA-DR are associated with APS manifestations, even in patients who do not meet the diagnostic criteria for APS because they are negative for conventional aPLs.
The latest prospective, multicenter, cross-sectional study, of 227 couples with recurrent pregnancy loss (RPL), which is one of the clinical manifestations of APS, revealed that 22.9% (52/227) of women with RPL tested positive for anti-β2GPI/HLA-DR (< 99th percentile values measured in sera of 208 healthy, fertile control women) [19]. In this study, anti-β2GPI/HLA-DR were detected most frequently in women with RPL among other commonly recognized risk factors for RPL, i.e., uterine malformation, thyroid dysfunction, chromosomal abnormality, aPLs positive, low factor XII activity, low protein S activity, and low protein C activity (Figure 2). Importantly, 53.3% (121/227) of women with RPL had no commonly accepted risk factors for RPL, and 24 of these 121 (19.8%) women with unexplained RPL were positive for anti-β2GPI/HLA-DR (Figure 2). In addition, 45 of the 227 women with RPL (19.8%) were positive for at least one of the 5 conventional aPLs meeting the diagnostic criteria for APS in this study, i.e., IgG aCL (8.8%), IgM aCL (6.2%), IgG aβ2GPI (3.1%), IgM aβ2GPI (1.3%), and LAC (2.6%). The rate of positivity for anti-β2GPI/HLA-DR was the highest (22.9%) of the 5 aPLs that met the diagnostic criteria for APS. Notably, 35 (67.3%) of the 52 women with RPL who were positive for anti-β2GPI/HLA-DR, were negative for APS laboratory criteria (Figure 3).
Risk factors for recurrent pregnancy loss (RPL) among 227 women with RPL. All women with RPL enrolled in this study attended evaluations to identify commonly accepted risk factors for RPL. Black pie slices indicate the frequencies of women with RPL who were also positive for anti-β2GPI/HLA-DR (n = 52). Abbreviations: aPLs, antiphospholipid antibodies.
Positivity for anti-β2-glycoprotein I /HLA-DR antibodies (anti-β2GPI/HLA-DR) and antiphospholipid antibodies (aPLs) in 227 women with recurrent pregnancy loss (RPL). Numbers in the Venn diagram represent the number of women who had unique or nonunique results in tests for aPLs and anti-β2GPI/HLA-DR. abbreviations: Ig, immunoglobulin; HLA, human leukocyte antigen; β2GPI, β2-glycoprotein I; aβ2GPI, anti-β2-glycoprotein I antibody; aCL, anti-cardiolipin antibody; LAC, lupus anticoagulant.
On the other hand, the presence of multiple aPLs and LAC positivity has been reported to be strongly associated with the severity of clinical manifestations of APS [21, 22, 23, 24, 25, 26]. In our study, all 3 women with RPL who had double or triple aPLs positivity were also positive for anti-β2GPI/HLA-DR, and the 2 with triple positivity had very high anti-β2GPI/HLA-DR levels (927.5 units and 330.7 units). First of both women experienced early-onset HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) at 14 weeks of gestation, and the second experienced a thromboembolism with cerebral infarction [19]. Multiple positivity for aPLs may be associated with higher levels of anti-β2GPI/HLA-DR, and these conditions may be closely associated with the severity of the clinical manifestations of APS.
The standard treatment for pregnant women with APS is combination therapy with heparin and low-dose aspirin (LDA) [27], and the same therapy could also be effective in the treatment of women with RPL and anti-β2GPI/HLA-DR positivity. A cohort study is already underway to assess the efficacy of LDA and/or heparin therapy in such women. The history of vascular thrombosis and obstetric complications, including hypertensive disorders of pregnancy and fetal growth restriction, has not been investigated in prospective studies. Future studies assessing whether anti-β2GPI/HLA-DR are associated with thrombosis, hypertensive disorders of pregnancy, and fetal growth restriction are needed.
Further understanding of these novel autoantibodies associated with novel function of HLA class II molecules will provide new insights into the etiology of not only APS but also other autoimmune diseases and might lead to development of new treatment strategies for these diseases.
The global Covid-19 situation has presented new food production, distribution, and consumption challenges and has potentially exacerbated existing inequalities for those in deprived areas. Significantly, the implications of the Covid-19 pandemic on global food supply chains and food systems’ resilience have aggravated food insecurity indicators. As defined by the Food and Agriculture Organisation (FAO), food security is a condition that “exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life” ([1], p. 49). The FAO estimates that up to 811 million people worldwide faced hunger in 2020 – up to 161 million more than in 2019 – as conflict, climate extremes, and economic slowdowns, aggravated by the Covid-19 pandemic, continued to increase in frequency and intensity [2]. The World Food Program (WFP) calculated that the number of acutely food insecure people in the countries where it operates reached more than 271 million people directly due to the aggravating impact of the Covid-19 pandemic. In the UK, it is estimated that the number of people experiencing food insecurity quadrupled due to lack of food in shops, economic impacts, and isolation brought about by the pandemic [3].
As well as these challenges, the Covid-19 situation presents new opportunities for local food initiatives to work differently, increase collaboration, and improve outcomes for those most in need. Local food initiatives usually refer to social innovations that aim to address environmental and social issues derived from current food system structures, reconfiguring food supply chains and relations within a locality [4]. The collective responses of local food initiatives to the disruption caused by Covid-19 provide the perfect space to increase knowledge about how local food systems – collaborative networks that integrate individual local food initiatives efforts [5] – and could potentially lead to better food security outcomes. Case studies have increasingly documented how networked responses in diverse local communities during the Covid-19 crisis managed to respond to rising food insecurity needs and the opportunities this might provide for food systems change [3, 6]. Our research aimed to expand this body of literature by providing knowledge about how various local food initiatives interact, cooperate, and collaborate, how these changed during the Covid-19 pandemic and what this means for a local food system. To date, there are few studies that have investigated the changing structure of local food systems using a comparative research design before and during a disruption. Lessons learned from this examination might help local responses to future crises such as the climate crisis and other external stresses that affect food systems and society.
We focus on the local food system of the Local Authority Area of Preston in the Lancashire region of the UK. In the first section of the chapter, food security resilience is introduced. By providing an overview of the concepts of resilience and social capital, a theoretical framework is presented that is used to unpack the dynamics of Preston’s local food system. The following section outline the methodology used to study Preston’s local food system – namely, a social network analysis (SNA) conducted during 2020, examining collaborative relationships before and during the crisis, and online semi-structured interviews with a subset of local food initiatives. Next, the results from the research are presented in order to illuminate the changing characteristics of the local food system and its potential outcomes. The final section returns to the concept of food security resilience, using social capital as a proxy, to highlight important lessons learned from the case study presented, namely the relevance of previous social preconditions to ensure adaptation and response.
Resilience is a concept that holds different meanings depending on the various situations in which it is being used [7]. Ecology literature usually frames resilience as a technical concept that refers to the “capacity of a system to withstand shocks and external pressures while maintaining its basic structure, processes, and functions” ([8], p. 601) In this context, resilience was perceived as an isolated ‘outcome’ rather than connected to specific abilities, as many academics and practitioners now recognise [9]. Resilience thinking has expanded from this initial narrow definition by integrating adaptability and transformability as crucial ingredients [10, 11]. Social theory has contributed to this reconceptualisation adding essential dimensions, such as agency and collective action, to the concept [12]. As such, resilience is defined at the communal rather than individual level, focusing on coordinated efforts and cooperative adaptation [13]. Here, resilience refers to the ability of a given community or group to cope with external shocks and disturbances to its infrastructure and functioning [10]. It involves both the capacity to learn and adapt to ongoing pressures using existing economic, social, and environmental resources while also developing new strategies and capabilities [11].
Both literature and practice have increasingly acknowledged the potential of resilience thinking to contribute to food security. Tendall et al. [14] develop the notion of food security resilience at the system level by breaking it down into four components: robustness (the capacity to withstand the disturbance in the first place before any food security is lost); redundancy (the extent to which elements of the system are replaceable, affecting the capacity to absorb the perturbing effect of the disturbance and avoid as much food insecurity as possible); flexibility and thus rapidity (or the speed with which the food system can recover any lost food security); and finally, resourcefulness and adaptability (how much of the lost food security is recovered). More broadly, it has been argued that food security resilience is “about the capacities of households and communities, to deal with adverse events in a way that does not affect negatively their long-term wellbeing and/or functioning” ([12], p. 806). Although Tendall et al.’s [14] definition offers a strong starting point to understand how particular local food systems have been able to respond to the Covid-19 pandemic, resilience variables such as those proposed are difficult to observe and measure, and there is no current consensus on how to do so [7].
Therefore, to understand how local food systems can contribute to food security and what is needed to address external stresses, this study assessed the changes in
Overall, there is not a universal definition of social capital [16]. Adler and Known [17] categorised definitions of social capital depending on whether their focus was on an individual or a collective group, and divided the definitions into three categories. The first refers to social capital as a resource that an individual has as a result of their external linkages with other actors [13]. The second category focuses on the structure of relations of multiple actors that give the collectivity cohesiveness, which facilitate common goals. In this category, social capital is defined as “the features of social organisation, such as trust, norms, and networks, that can improve the efficiency of society by facilitating coordinated actions” ([18], p. 167). It is thus defined by its function to facilitate certain action within a social structure [19]. The third category of social capital refers to both external linkages and internal linkages of a social grouping. The current study adopts the second view of social capital, as it allows the analysing of local food systems’ structure and the collective characteristics that facilitate action in times of crisis. In this regard, it moves away from focussing on an individual resource pool to address adversity towards the social resilience capacities of local food systems as a whole.
To aid the analysis of social capital influence upon the response of local food systems to emergencies, two forms of social capital are examined: bonding and bridging social capital. Bonding usually refers to strong and emotional connections, such as friends or family, among individuals that commonly share similar characteristics in class, race, attitudes, and available information and resources [17, 18, 20]. Bridging describes loose relationships that enables information to be exchanged across diverse groups [16]. Bridging social capital, in contrast to bonding social capital, usually appears in more open networks, increasing chances to expand and access new relationships, information, resources, and opportunities [21].
The methodology used in this study involved a three-phase process. Phase I consisted of an initial internet search to identify a preliminary list of local food initiatives supporting one or more areas that contribute to the sustainability and food security of the Preston, Lancashire area. Local food initiatives in Preston were identified based on their nature as a component of a local food system as characterised by Clément [22]. Clément identifies local food initiatives as those that focus on direct local food marketing, local food procurement, food access programmes, and food education and policy [21]. We added an overarching criteria of having a specific focus on improving food security and sustainability at the local level and follow ethical principles to differentiate them from the conventional food system [23]. We initially identified 44 organisations in Preston that could be considered local food initiatives working within the local food system.
Phase II involved gathering survey data from key personnel working in these organisations to establish which local food initiatives have active relationships and collaborations and which are more marginal within Preston’s local food system. The survey identified how these connections have changed since the Covid-19 crisis developed and enabled comparison with pre-Covid-19 relationships. To do this, we asked questions relating to the scale of interactions between organisations before and during the crisis. To answer these questions participants had to indicate which option best described their relationship with other organisations in the local food system. The scale used in the study was derived from the four Cs of interorganisational partnering to respond to a disaster and Himmelman’s collaboration continuum [24, 25]. Reflecting increasing degrees of interaction and integration with other organisations, the options provided were ‘communicating’ (exchange of ideas and information), ‘sharing’ (communicating and sharing of resources for mutual benefit), and ‘collaborating’ (communicating, sharing and working together to create something new). Based on the definitions of bonding and bridging social capital, collaborating refers to the former, while communicating and sharing to the latter.
The survey analysis was coupled with SNA to measure the social capital features of the local food system, following a network approach to social capital, which focuses on the patterns and collection of relationships within a group [26]. SNA has been identified as beneficial for demonstrating the relationships among food systems’ actors both visually and numerically [27]. Gephi, an open-source platform for visualising and analysing network graph data, was used to analyse network-based questions to assess the overall characteristics of the local food system and identify central actors within it. Of the 44 identified organisations, 21 local food initiatives completed the survey. Although there are various methods available to impute the missing data of non-respondents, doing so can create biased network measures and metrics [28]. Missing data in this context is missing at random and the probability of it being missing is unrelated to the value of the missing connections and observed organisational attributes [29]. Therefore, the analysis was based on the 21 responses from local food initiatives that we received. Phase III included semi-structured interviews with key stakeholders in the local food system and will be discussed further in Section 2.3.
Data about social networks is depicted as sociograms. Sociograms are graphs showing network actors (in our case these are local food initiatives which are represented as ‘nodes’ in the network) and their relationships (these are the connections between the local food initiatives and are represented as ‘edges’) [30]. Relationships (edges) can be directed (having a certain quality that can be different in both directions) or undirected (where the type of relationship is not specified). We gathered information about both, as knowing the direction of the edges can provide information about reciprocal relationships. Reciprocal relationships denote the level of trust between organisations because it reflects the cultivation and utilisation of tangible and intangible resources by network members for the common interest [16, 21]. Figures 1 and 2 illustrate the sociograms of the relationships among organisations before Covid-19 and during Covid-19. For the SNA, we concentrated on measures of connectivity and centrality1, as they represent some of the fundamental structural properties of importance to any network and have been used to clarify the vulnerability of networks [30].
Sociogram pre-Covid-19 - Preston’s local food system.
Sociogram during Covid-19 - Preston’s local food system.
Table 1 shows the local food system’s connectivity network measures, comparing pre-and during Covid-19. Network diameter is the longest distance between any two nodes (i.e., how many edges are between the two most distant nodes). A short network diameter means it is possible to move through the network in a very few steps through a small number of nodes and implies that an idea or resource will spread quickly across the network, signalling integration to the system [31]. The average path length is the mean distance between all possible pairs of nodes in the network; the closer to 1, the more connected the network [32]. In the case of Preston, with a diameter of 2 and an average path length of approx. 1.5 even before Covid-19, the local food system was already ‘compact’ [33].
Metric | Pre-Covid-19 | during Covid-19 |
---|---|---|
Network Diameter | 2 | 2 |
Network Density | 0.442 | 0.453 |
Average Path Length | 1.568 | 1.553 |
Connectivity measures in Preston’s local food system.
Similarly, network density – the number of identified links divided by the maximum possible number of links [32] – remains between 0.44 and 0.45. This measure captures the bonding social capital within the local food system, reflecting sociological ideas like cohesion, solidarity, and membership, by calculating how many edges exist between actors compared to how many edges between actors are possible; the closer to 1, the more connected the network is [34]. In terms of resilience, having a medium network density, low diameter, and average path length means that resources can spread quickly between organisations. In times of crisis, such connectivity can facilitate rapid social action and setting up new processes and activities without the potential for duplication of activity and attendant waste of resources, making it easier to respond to changing situations such as Covid-19. This could explain the successful response to food insecurity described by participants (see Section 2.3.). Based on these measures, it could be argued that Preston’s local food system already possessed a strong level of bonding social capital, as it demonstrates collective cohesiveness. However, as will be seen next, this changes when looking at the
Figure 1 illustrates the overarching interconnectivity between organisations of Preston’s local food system before Covid-19. The size of the nodes in the sociograms indicates the importance of an organisation within the network. The edges (connections) are coloured based on the type of relationship: blue: communicating, red: sharing, green: collaborating. The local food system before Covid-19 already shows a high number of edges between the many organisations within it. Approximately half of edges were collaborative relationships, and the other half were communicating and sharing connections (see Figure 1). Notably, the sociogram pre-Covid-19 presents a small network of organisations, which share collaborative ties with the same initiatives. In this regard, there was a strong presence of bridging social capital exemplified through weaker ties such as communicating or resource sharing, with a sub-group of organisations with an enhanced bonding social capital reflected through collaborative relationships.
Comparing the sociograms before and during Covid-19, it can be identified that the pandemic has affected the associations between local food systems’ members, although the overall features of the local food system remain the same. Significantly, it has increased the quality of interactions. Figure 2 illustrates a higher number of green coloured, collaborative relationships across the local food system, accounting for 60% of the edges. In this regard, many weaker connections in the form of sharing and communicating pre-Covid-19 were replaced by collaborations during-Covid-19, signalling the creation of bonding social capital from previous connections based on bridging social capital.
Despite the overarching interconnectivity between organisations within Preston’s local food system, it can be identified that a small number of organisations have particularly central roles in the network, which has been strengthened during Covid-19. To understand the role of specific organisations within the network, we used centrality measures to identify the most connected actors in the network that hold a significantly higher than average number of links [31]. In-degree centrality is the number of edges pointing towards a node, i.e., how popular or sought-after a given organisation is. Out-degree centrality denotes the outgoing connections of a node with other organisations, which refers to the sociability or outreach of an organisation [31]. This is important to understand the social resilience capacities of a local food system, as it points to particularly influential and prominent actors that could facilitate rapid response, network organisation, or those holding the resources needed to adapt. Table 2 presents the degree centrality per organisation. The nodes in Figures 1 and 2 are sized according to their in-degree centrality score, which indicates the number of incoming links a local food initiative possesses. From this, four organisations, the local authority, the food redistributor, CGA (a community housing association), and Let us Grow Preston (LGP - a network of community gardens), can be identified as having high levels of in-degree and out-degree centrality. As such, they hold an advantageous position concerning their roles and leadership within the local food system. This has remained during Covid-19, albeit with the scores increasing for each organisation, indicating an increased number of connections.
Local authority | 13 | 15 | 16 | 16 | 0.239 | 0.354 | 0.942 | 0.960 |
CGA | 11 | 13 | 8 | 9 | 0.053 | 0.094 | 0.953 | 0.989 |
Food redistributor | 11 | 12 | 8 | 7 | 0.053 | 0.066 | 1.000 | 1.000 |
Let us Grow Preston | 9 | 10 | 12 | 13 | 0.119 | 0.122 | 0.720 | 0.709 |
Food bank2 | 7 | 7 | 2 | 2 | 0.000 | 0.000 | 0.584 | 0.536 |
Fulwood Food Bank | 6 | 7 | 0 | 2 | 0.000 | 0.055 | 0.569 | 0.519 |
British Red Cross | 6 | 6 | 1 | 1 | 0.003 | 0.002 | 0.571 | 0.522 |
Sahara Centre | 6 | 6 | 15 | 14 | 0.086 | 0.053 | 0.635 | 0.572 |
The Larder | 6 | 6 | 7 | 6 | 0.027 | 0.111 | 0.619 | 0.560 |
Avenh. C.Garden | 5 | 5 | 4 | 3 | 0.016 | 0.006 | 0.436 | 0.401 |
Grimshaw St. Community C. | 5 | 7 | 3 | 4 | 0.001 | 0.007 | 0.509 | 0.524 |
Fishwick Food Bank | 4 | 5 | 1 | 8 | 0.001 | 0.005 | 0.451 | 0.450 |
Food bank1 | 4 | 5 | 5 | 2 | 0.003 | 0.000 | 0.465 | 0.500 |
Larches and S. Community A. | 4 | 4 | 9 | 7 | 0.010 | 0.006 | 0.534 | 0.506 |
Millbank Wellbeing C. | 4 | 4 | 7 | 8 | 0.004 | 0.007 | 0.487 | 0.449 |
Ascension Church | 3 | 3 | 0 | 4 | 0.000 | 0.001 | 0.352 | 0.407 |
Community C. Groups | 3 | 1 | 3 | 6 | 0.008 | 0.005 | 0.187 | 0.012 |
Churches Together | 2 | 4 | 3 | 3 | 0.001 | 0.003 | 0.287 | 0.423 |
Comunity Garden | 2 | 3 | 3 | 3 | 0.000 | 0.005 | 0.200 | 0.234 |
Food Futures | 2 | 1 | 6 | 6 | 0.003 | 0.054 | 0.184 | 0.077 |
Centrality measures per node.
Betweenness centrality measures how often a node lies on the shortest path between two other notes. This helps to identify the brokers or gatekeepers, those with links that stretch well beyond their local network neighbours, as these nodes are the critical actors on the path for routes of exchange. Eigenvector centrality measures the influence of a node in a network concerning the importance or connectedness of its neighbours [35]. Both betweenness and eigenvector centrality refers to the effect that an organisation may have within a network. Based on their eigenvector and betweenness scores (see Table 2), the local authority and LGP are also the most strategically located overall to create links with other local food initiatives and share information and resources [31, 36]. The position of these organisations has been strengthened during Covid-19, indicating their potential role in structuring an organised response to the crisis, act as a bridge to facilitate information exchange and new information flows (bridging social capital), and increasing trustful connections (bonding social capital).
The following section uses data from semi-structured interviews to build on these findings and provide explanations for why Preston’s local food system has remained relatively unchanged in terms of overall characteristics, but more significantly changes in relation to the strength of ties. It explains how the previous structure of the local food system helped a coordinated response to the crisis, and the role of LGP and the local authority in facilitating coordination.
In addition to the survey and SNA, we conducted semi-structured, in-depth interviews with a purposively selected subset of survey respondents. Of the 21 respondents to the survey, nine participated in this Phase. Additionally, to gain a deeper insight into Preston’s local food system, two local food researchers who had been involved in collaborative work within the local food system before Covid-19 were interviewed. Interviews lasted between 45 and 90 minutes, were conducted online following Covid-19 restrictions, and were recorded with the participant’s consent. Interviews were transcribed, and analysis was supported by NVivo software, following Stake’s [37] guidelines to qualitative case study analysis, which focuses on pattern recognition across the collected data. The use of case study analysis was intended to gather further explanatory details about the local food system and its changes.
As the SNA has shown, Preston’s local food system already had a high degree of connections before Covid-19, including both bonding and bridging social capital. This is mainly because Preston’s local authority had created a space in 2019 where local food initiatives within Preston could share their approach to food insecurity, could discuss various models of food aid provision, and foster mutual learning. According to participants, this initiative was taken up very positively by local food initiatives:
This demonstrates the potential for developing bonding social capital was present before COVID-19, fostering stronger collective sharing and mutual learning. With the facilitation of the local authority, this embryonic food poverty alliance was working closely with LGP, a community gardens network initiated by the local authority, to grow and collect surplus food from allotments and gardens to use the produce in food insecurity schemes and nutrition education. These events prior to Covid-19 further suggest the centrality of local authorities in fostering coordinated approaches towards food-related issues and increasing social capital within local food systems. In addition, while the local food system was not necessarily demonstrating strong
Interview findings corroborated the centrality of the local authority and the importance of previous relationships, as found through the SNA, to respond to the Covid-19 food insecurity crisis in the city. Covid-19 acted as a catalyst for the food poverty alliance by strengthening ties that pre-existed the pandemic. Pre-existing relationships that previously simply shared information, extended to collectively working towards a common purpose. In March 2020, the local authority called for a joint meeting of the food poverty alliance and other local food initiatives working on food access and LGP, leading to the creation of a WhatsApp group for coordination. Multiple interviewees reinforced the importance of the council’s leadership in ensuring the successful organisation of networked responses:
The importance of the local authority role in coordinating the food poverty alliance is not only because many local food initiatives are reliant on external funding. Participants, including the local authority, perceived that the alliance was moderated and formed in an inclusive and accepting manner, leading to a feeling of building collective realities and a shared mission under a notion of diversity:
This signals a high level of respect among the participants of the food poverty alliance, acknowledging the uniqueness of each. Significantly, this indicates that bonding social capital and cohesiveness can still be present in non-homogenous groups, leading to a closely connected network, yet open enough to accept new entries. This acknowledgment of diversity within the alliance has led to the development of new connections. Interviewees agreed that Covid-19 prompted new relations between organisations, which might not have been considered previously. Covid-19 prompted a closer collaboration between food banks organised by diverse faith and ethnic groups and community gardens and sustainable food initiatives. This lead to a cross-fertilisation of beliefs, demographics, and purposes. In terms of social resilience capacity, this meant that bridging social capital was invigorated, promoting channels for the food poverty alliance to expand and potentially build stronger links with heterogenous groups. Indeed, the ability to respond quickly to Covid-19 in terms of food access was attributed to the strengthening of the relationships among these diverse groups:
This experience emphasises the importance of developing trust and mutual support in collaborative relationships. In Preston’s case, Covid-19 acted as a catalyst to reach higher levels of these attributes, helping member organisations to collectively overcome the challenges imposed by COVID-19 due to the increased strength of their connections. This increased coherence and thus new-found bonding capital among local food initiatives also meant a better response to food access concerns that might have been overlooked otherwise. Notably, this was related to the increased information sharing among organisations and the exchange of food and resources. While talking about the benefits of joint coordination, one participant explained how, with the help of various providers, they were able to respond to a gap in food access for students in the city:
This communication between the food initiatives and the university ultimately led to a process being put in place to support these students. The university was not one of the organisations identified for the SNA as they are not a significant part of the local food system in the city, but this example illustrates how a local food system with strong bridging and bonding capital can swiftly identify and support other organisations outside of already established platforms. Furthermore, the ability to feed back to the food poverty alliance was highlighted as important for making sure that those in vulnerable positions were receiving food according to their needs, culture, and eating habits. Significantly, these examples elicited reflection across the local food initiatives, and led to discussions that questioned the adequacy of some of the models and food currently being used:
The above statements illustrate ways in which having spaces for discussion and knowledge exchange helps initiatives to move beyond a model of emergency food aid that mainly uses surplus food. Indeed, the prominent participation of LGP, which during the pandemic decided to grow as much food as possible and collect as much fresh local food from allotments and community gardens for the food poverty alliance, has signalled a possible mechanism for introducing other local and sustainable food to address food insecurity needs. The local authority reflects this sentiment:
Although ‘it is by no means perfect’ and ‘there is still a lot to do’, as participants mentioned, the development of the local food system in Preston suggests the importance of developing both bridging and bonding social capital through strong collaborative links and information exchange across the diversity of organisations in the local food system to be able to respond better to future crises. Notably, the role of local authorities has been identified as key in such a process. More importantly, the Covid-19 pandemic has fostered the creation of spaces of mutual reflection, whereby the purpose and avenues of emergency food aid are reconsidered, and more sustainable and structural strategies are considered.
This analysis of how the relationships between Preston’s local food initiatives changed because of the Covid-19 pandemic reveals the importance of how social resilience capacities can help communities better respond to shocks and disturbances. Within this local food system strong communicative, sharing, and collaborative relationships and connections were already present before the pandemic hit, with engagement occurring across an already highly connected network. Collaboration, mutual sharing, and communication between different types of local food initiative indicate the presence of both bonding (strong collaborative connections) and bridging (loose relations through sharing and communicating) social capital before Covid-19. In particular, the prior formation of a food poverty alliance by the local authority provided the opportunity to construct a relatively cohesive response to food insecurity. Findings highlight that the critical component of these ties is the quick mobilisation of resources (e.g., food and information). This provided the capacity during Covid-19 to ensure food access across multiple communities during this major disruption to food systems and society’s structures. Reflecting on these features of local food systems in relation to the literature on resilience and social capital, can help us better understand the role of networks of local food initiatives in adaptation, crisis mitigation and collective reflection and what these dynamics could mean for future successful food security responses.
Returning to the two types of social capital used to analyse the food security resilience capacity of Preston’s local food system, it can be argued that bonding and bridging social capital worked in complementary but distinct ways before and during the crises [21]. Bonding social capital, due to preparatory work of the food poverty alliance, helped the local food system adapt quickly to new ways of delivering food, whilst bridging capital helped integrate a more diverse set of local food initiatives. As explained by Putnam, bonding social capital fosters mobilising solidarity, allowing communities to ‘get by’, as in the case of increasing exchange of food and resources in Preston. On the other hand, bridging social capital is essential to ‘get ahead’, broadening identities and reciprocity across diverse groups [21]. In this regard, despite the presence of a relatively collaborative network before Covid-19, which others have argued can limit possibilities for expansion and inclusion [13], the presence of bridging social capital before Covid-19 might have helped the ‘openness’ of the alliance to create bridges across local food initiatives in terms of religion, type and beneficiaries. In addition, results show how a particular emergency can increase the level and type of social capital within local food systems, from loose connections based on information sharing to collaborative ties, leading to greater bonding social capital. Increased bonding social capital has been related to trust and a sense of unity within communities [38]. Indeed, interviews highlight new levels of trust and respect among the food poverty alliance and across the local food system, working towards a common aim in a recognition of diversity as a result of newer collaborative relationships.
The literature on local food systems and local food initiatives has increasingly identified the potential benefits of increased collaboration between different types of organisations working on food-related concerns [39, 40, 41]. Our findings show that providing the space for local food initiatives to meet helps shape and develop relationships. This has enabled discussions within the local food system about some of the disadvantages of food aid and the potential to develop avenues of support that can bring about better food insecurity solutions. In particular, this has demonstrated the possibility of creating a bridge between organisations working with vulnerable communities and those focusing on local food, spaces which have previously been heavily criticised for being exclusionary and ‘elitist’ [42]. Moreover, food aid organisations have frequently been presented as supporting short-term strategies that concentrate on emergency patch work and sacrificing long-term solutions, thereby creating dependant and passive recipients of charity whilst also benefiting big corporations along the way [43, 44]. Providing spaces of deliberation for initiatives within the local food system to develop collective responses to food insecurity is shown to increase the possibility of questioning current models of food provisioning and to develop more imaginative structural solutions.
In addition, this study highlights the importance of a neutral organisation, with resources and strategically located in the local food system, to bridge ties between diverse organisations. Preston’s case showcases the role of city councils in developing social capital within local food systems [16]. This means that urban food governance – the modes of interaction within local food systems and the operational and decision-making mechanisms that steer changes in it – have the potential to create synergies within local food systems [45]. Notably, given that local food initiatives often have limited capacities to manage collaborative spaces [46, 47], local authorities have the advantaged position to adopt a leading role in forming partnerships and strategies within the local food system and more so in times of crisis. Moreover, the above findings lend support to acknowledging the need for a coordinated response to emergency situations and crisis. However, this does not mean that, after crisis mitigation, no contingency plans should be adopted in these new collaborative spaces. Previous studies have highlighted the lack of consideration of vulnerabilities of food supply structures and crisis management plans in local food strategies and partnerships [48]. In this sense, local authorities should also take advantage of the collectivisation of food security responses to learn from the experience of the Covid-19 pandemic and ensure that structures, in combination with social resilience capacities, are in place to respond effectively to emerging risks.
Although the lessons learnt from Preston’s case reveal the importance of social resilience capacities and urban food governance in being able to respond and adapt to sudden emergencies to ensure food security, the long-term impacts of the changes Covid-19 has had on the dynamics of local food systems remain to be seen. Bonding capital could lead to a close network of those already established initiatives, with less opportunity for others to join. Higher levels of trust among the food poverty alliance might also act as a barrier [36]. In particular, there is a risk of stagnation if the considerations resulting from the reflexive discussions and dialogue among local food initiatives does not lead to a broader focus beyond food poverty. Scholars indicate the deficiencies and challenges of a siloed focus of urban food governance spaces, such as diminishing its potential to create more transformative interventions [48, 49].
This article has sought to draw attention to the role of social resilience capacities in helping communities to self-organise and respond to difficult circumstances, especially during times of crises and disruption. This study is primarily aimed at revealing the structures needed to ensure that food access is guaranteed across diverse communities in all circumstances. Using SNA and semi-structured interviews with key actors within Preston’s local food system, this research has helped shed some light on the relevance of social capital, both bridging and bonding, in developing collective food security responses in times of crises. Although it is essential to ensure physical infrastructures such as food supply chains and storage are in place to support food security, building social infrastructures like cohesion and trust across local food systems should also become a priority in cities to support populations, particularly those most vulnerable, in disaster. A key actor in Preston in developing these processes has been the local authority. As such, the research finds evidence good urban food governance is important for leveraging the collectivisation of food insecurity initiatives. Given that social capital can be fostered or deteriorated [16], a key focus in the future of local food systems, and urban food governance, should be on harnessing the new found bonding social capital to increase cohesiveness, but also seek to build up connections across diverse communities and local food initiatives.
While we acknowledge that our case may not be representative of all local food systems, it provides a place to begin unpacking the relevance of local food initiatives’ relations in addressing food security challenges. The inclusion of diversity within already established networks and alliances within local food systems can lead to collective reflexive processes and questioning of current approaches to food system deficiencies. Future research should examine how the increased collaborative ties developed by the Covid-19 pandemic are affecting local food systems’ dynamics in the long-term and if these help move those systems beyond charity-based approaches to food insecurity. A particular focus should be if the increased connectedness of communities and local food initiatives due to solidarity remains even when external shocks are no longer a threat, working towards a collective effort to ensure food for all. With increased research in these areas and others, we will begin to better understand the nuanced nature of social capital and local food initiatives relations for food security resilience and creation of long-term solutions to food insecurity within local food systems.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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\n\n\n\nIntechOpen publishes different types of publications.
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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. 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After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"onlineFirst.detail",path:"/online-first/80388",hash:"",query:{},params:{id:"80388"},fullPath:"/online-first/80388",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()