\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"5323",leadTitle:null,fullTitle:"Modeling and Simulation in Engineering Sciences",title:"Modeling and Simulation in Engineering Sciences",subtitle:null,reviewType:"peer-reviewed",abstract:"This book features state-of-the-art contributions in mathematical, experimental and numerical simulations in engineering sciences. The contributions in this book, which comprise twelve chapters, are organized in six sections spanning mechanical, aerospace, electrical, electronic, computer, materials, geotechnical and chemical engineering. Topics include metal micro-forming, compressible reactive flows, radio frequency circuits, barrier infrared detectors, fiber Bragg and long-period fiber gratings, semiconductor modelling, many-core architecture computers, laser processing of materials, alloy phase decomposition, nanofluids, geo-materials and rheo-kinetics. Contributors are from Europe, China, Mexico, Malaysia and Iran. The chapters feature many sophisticated approaches including Monte Carlo simulation, FLUENT and ABAQUS computational modelling, discrete element modelling and partitioned frequency-time methods. The book will be of interest to researchers and also consultants engaged in many areas of engineering simulation.",isbn:"978-953-51-2609-6",printIsbn:"978-953-51-2608-9",pdfIsbn:"978-953-51-4188-4",doi:"10.5772/62109",price:139,priceEur:155,priceUsd:179,slug:"modeling-and-simulation-in-engineering-sciences",numberOfPages:302,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"684a6db4422b067b280c33faf661d747",bookSignature:"Noreen Sher Akbar and O. Anwar Beg",publishedDate:"August 31st 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5323.jpg",numberOfDownloads:21952,numberOfWosCitations:49,numberOfCrossrefCitations:30,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:56,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:135,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 15th 2015",dateEndSecondStepPublish:"November 5th 2015",dateEndThirdStepPublish:"April 1st 2016",dateEndFourthStepPublish:"March 2nd 2016",dateEndFifthStepPublish:"October 5th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"184401",title:"Dr.",name:"Noreen",middleName:null,surname:"Sher Akbar",slug:"noreen-sher-akbar",fullName:"Noreen Sher Akbar",profilePictureURL:"https://mts.intechopen.com/storage/users/184401/images/4760_n.png",biography:"Dr. Noreen Sher Akbar joined National University of Sciences and Technology, Islamabad, Pakistan, in 2012. She works in fluid mechanics, heat transfer and nanofluids. She obtained her Ph.D. in 2012 in applied mathematics (fluid mechanics). She has published over 230 journal papers and won several awards for teaching and research. She was declared as the best youngest scientist of Pakistan.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"188191",title:"Dr.",name:"Anwar",middleName:null,surname:"Beg",slug:"anwar-beg",fullName:"Anwar Beg",profilePictureURL:"https://mts.intechopen.com/storage/users/188191/images/4923_n.png",biography:"Dr. O. Anwar Bég joined Salford University in March 2016. He works in fluid mechanics and heat transfer. He obtained his Ph.D. in 1995 in computational magnetohydrodynamics from Manchester University, UK. He has taught fire, aerospace and mechanical engineering at several universities. He has published over 320 journal papers and 5 books and won several awards for teaching and research.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Salford",institutionURL:null,country:{name:"United Kingdom"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"599",title:"Computer Simulation",slug:"numerical-analysis-and-scientific-computing-computer-simulation"}],chapters:[{id:"51716",title:"Numerical Simulation in Microforming for Very Small Metal Elements",doi:"10.5772/64275",slug:"numerical-simulation-in-microforming-for-very-small-metal-elements",totalDownloads:2100,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Microforming is a technology of very small metal elements production, which are required as a parts for many industrial products resulting from microtechnology. This chapter gives a review of the state-of-the-art microforming of metals and its numerical simulations. Phenomena occurring in the miniaturization of microbulk-forming technologies are described. The main problems in microforming are size effects, which have physical and structural sources and directly affect the material flow mechanics in microscale. Size effects must be taken into account in all areas of the forming process chain, demanding new solutions, especially in workpiece structure and die surface numerical modeling.",signatures:"Krzysztof Mogielnicki",downloadPdfUrl:"/chapter/pdf-download/51716",previewPdfUrl:"/chapter/pdf-preview/51716",authors:[{id:"180033",title:"Dr.",name:"Krzysztof",surname:"Mogielnicki",slug:"krzysztof-mogielnicki",fullName:"Krzysztof Mogielnicki"}],corrections:null},{id:"50939",title:"Numerical Simulation of Compressible Reactive Flows",doi:"10.5772/63906",slug:"numerical-simulation-of-compressible-reactive-flows",totalDownloads:1658,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Numerical simulation has been widely employed to investigate the compressible flows since it is difficult to carry out the experimental measurements, especially in the reactive flows. The shock-wave capturing scheme will be necessary for resolving the compressible flows, and moreover the careful treatments of chemical reaction should be considered for proceeding numerical simulation stable and fast. Recently, the present authors have tried to establish a high-resolution numerical solver for computing the compressible reactive flows. This chapter presents the numerical procedures acquired in this solver for computing the fluxes using weighted essentially non-oscillatory (WENO) scheme, dealing with chemical stiffness problems, and tracing droplets and their interaction with the compressible fluids. As examples, the Taylor-Green vortex (TGV) problem considering the passive scalar mixing, the spatially developing reactive mixing layer flows taken gas-phase hydrogen, and liquid n-decane as fuel are simulated, respectively. Many important characteristics of flow, flame, and ignition are analyzed under the supersonic condition.",signatures:"Bing Wang, Zhao Xin Ren and Wei Wei",downloadPdfUrl:"/chapter/pdf-download/50939",previewPdfUrl:"/chapter/pdf-preview/50939",authors:[{id:"180054",title:"Associate Prof.",name:"Bing",surname:"Wang",slug:"bing-wang",fullName:"Bing Wang"},{id:"187731",title:"Dr.",name:"ZhaoXin",surname:"Ren",slug:"zhaoxin-ren",fullName:"ZhaoXin Ren"},{id:"187733",title:"Dr.",name:"Wei",surname:"Wei",slug:"wei-wei",fullName:"Wei Wei"}],corrections:null},{id:"51509",title:"Hybrid Time-Frequency Numerical Simulation of Electronic Radio Frequency Systems",doi:"10.5772/64152",slug:"hybrid-time-frequency-numerical-simulation-of-electronic-radio-frequency-systems",totalDownloads:1284,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter is devoted to the discussion of a hybrid frequency-time CAD tool especially designed for the efficient numerical simulation of nonlinear electronic radio frequency circuits operating in an aperiodic slow time scale and a periodic fast time scale. Circuits driven by envelope-modulated signals, in which the baseband signal (the information) is aperiodic and has a spectral content of much lower frequency than the periodic carrier, are typical examples of practical interest involving such time evolution rates. The discussed method is tailored to take advantage of the circuits and signals heterogeneity and so will benefit from the time-domain latency of some state variables in the circuits. Because the aperiodic slowly varying state variables are treated only in time domain, the proposed method can be seen as a hybrid scheme combining multitime envelope transient harmonic balance based on a multivariate formulation, with a purely time-step integration scheme.",signatures:"Jorge F. Oliveira",downloadPdfUrl:"/chapter/pdf-download/51509",previewPdfUrl:"/chapter/pdf-preview/51509",authors:[{id:"180088",title:"Prof.",name:"Jorge",surname:"Oliveira",slug:"jorge-oliveira",fullName:"Jorge Oliveira"}],corrections:null},{id:"51331",title:"HgCdTe Mid- and Long-Wave Barrier Infrared Detectors for Higher Operating Temperature Condition",doi:"10.5772/63943",slug:"hgcdte-mid-and-long-wave-barrier-infrared-detectors-for-higher-operating-temperature-condition",totalDownloads:1737,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In the last decade, a new architecture design such as nBn device or unipolar barrier photodiode has been proposed to achieve high operating temperature condition. This idea has also been implemented into HgCdTe ternary material system. In this chapter, we present the status of HgCdTe barrier detectors grown by metalorganic chemical vapor deposition with emphasis on numerical simulations of their properties. The device concept of a specific barrier bandgap architecture integrated with Auger suppression is a proper solution for high operating temperature infrared detectors. The device performance is comparable with state-of-the-art HgCdTe photodiodes.",signatures:"Małgorzata Kopytko and Piotr Martyniuk",downloadPdfUrl:"/chapter/pdf-download/51331",previewPdfUrl:"/chapter/pdf-preview/51331",authors:[{id:"181172",title:"Dr.",name:"Małgorzata",surname:"Kopytko",slug:"malgorzata-kopytko",fullName:"Małgorzata Kopytko"},{id:"181173",title:"Dr.",name:"Piotr",surname:"Martyniuk",slug:"piotr-martyniuk",fullName:"Piotr Martyniuk"}],corrections:null},{id:"51455",title:"Numerical Simulation Methods Applied at Fiber Grating Sensors Design",doi:"10.5772/63890",slug:"numerical-simulation-methods-applied-at-fiber-grating-sensors-design",totalDownloads:1667,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The paper presents the results obtained in simulation of fiber Bragg grating (FBG) and long-period grating (LPG) sensors and their applications. The optical properties of FBG and LPG are firstly analyzed and, consequently, the basics of simulation models are provided. Coupled-mode theory and the transfer matrix methods are the two techniques used for the simulation of FBG and LPG. The numerical simulations are performed for an improved design of these types of fiber sensors, designs dedicated to specified applications. The different FBG types, i.e. the normal, chirped, apodized, according to different laws and tilted cases, are analyzed. Also, various LPG configurations are numerically simulated. The two main categories of sensing applications, for temperature and for mechanical stress/strain evaluation, are simulated for each type of fiber grating sensor. The chapter is intended to be a synthesis of already obtained results to which some results of research in development are added.",signatures:"Dan Savastru, Sorin Miclos, Marina Tautan and Ion Lancranjan",downloadPdfUrl:"/chapter/pdf-download/51455",previewPdfUrl:"/chapter/pdf-preview/51455",authors:[{id:"149668",title:"MSc.",name:"Ion",surname:"Lancranjan",slug:"ion-lancranjan",fullName:"Ion Lancranjan"},{id:"176874",title:"Dr.",name:"Dan",surname:"Savastru",slug:"dan-savastru",fullName:"Dan Savastru"},{id:"178994",title:"MSc.",name:"Sorin",surname:"Miclos",slug:"sorin-miclos",fullName:"Sorin Miclos"},{id:"181300",title:"Dr.",name:"Marina",surname:"Tautan",slug:"marina-tautan",fullName:"Marina Tautan"}],corrections:null},{id:"51855",title:"Charge Collection Physical Modeling for Soft Error Rate Computational Simulation in Digital Circuits",doi:"10.5772/64277",slug:"charge-collection-physical-modeling-for-soft-error-rate-computational-simulation-in-digital-circuits",totalDownloads:1964,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"This chapter describes a new computational approach for accurately modeling radiation-induced single-event transient current and charge collection at circuit level. This approach, called random-walk drift-diffusion (RWDD), is a fast Monte Carlo particle method based on a random-walk process that takes into account both diffusion and drift of carriers in a non-constant electric field both in space and time. After introducing the physical insights of the RWDD model, the chapter details the practical implementation of the method using an object-oriented programming language and its parallelization on graphical processing units. Besides, the capability of the approach to treat multiple node charge collection is presented. The chapter also details the coupling of the model either with an internal routine or with SPICE for circuit solving. Finally, the proposed approach is illustrated at device and circuit level, considering four different test vehicles in 65 nm technologies: a stand-alone transistor, a CMOS inverter, a SRAM cell and a flip-flop circuit. RWDD results are compared with data obtained from a full three-dimensional (3D) numerical approach (TCAD simulations) at transistor level. The importance of the circuit feedback on the charge-collection process is also demonstrated for devices connected to other circuit nodes.",signatures:"Jean-Luc Autran, Daniela Munteanu, Soilihi Moindjie, Tarek Saad\nSaoud, Victor Malherbe, Gilles Gasiot, Sylvain Clerc and Philippe\nRoche",downloadPdfUrl:"/chapter/pdf-download/51855",previewPdfUrl:"/chapter/pdf-preview/51855",authors:[{id:"14152",title:"Prof.",name:"Jean-Luc",surname:"Autran",slug:"jean-luc-autran",fullName:"Jean-Luc Autran"},{id:"14602",title:"Dr.",name:"Daniela",surname:"Munteanu",slug:"daniela-munteanu",fullName:"Daniela Munteanu"},{id:"156365",title:"Dr.",name:"Philippe",surname:"Roche",slug:"philippe-roche",fullName:"Philippe Roche"},{id:"156366",title:"Dr.",name:"Gilles",surname:"Gasiot",slug:"gilles-gasiot",fullName:"Gilles Gasiot"},{id:"188494",title:"MSc.",name:"Soilihi",surname:"Moindjie",slug:"soilihi-moindjie",fullName:"Soilihi Moindjie"},{id:"188495",title:"MSc.",name:"Tarek",surname:"Saad Saoud",slug:"tarek-saad-saoud",fullName:"Tarek Saad Saoud"},{id:"188496",title:"MSc.",name:"Victor",surname:"Malherbe",slug:"victor-malherbe",fullName:"Victor Malherbe"},{id:"188497",title:"Dr.",name:"Sylvain",surname:"Clerc",slug:"sylvain-clerc",fullName:"Sylvain Clerc"}],corrections:null},{id:"51611",title:"Training Images-Based Stochastic Simulation on Many-Core Architectures",doi:"10.5772/64276",slug:"training-images-based-stochastic-simulation-on-many-core-architectures",totalDownloads:1660,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the past decades, multiple-point geostatistical methods (MPS) are increasing in popularity in various fields. Compared with the traditional techniques, MPS techniques have the ability to characterize geological reality that commonly has complex structures such as curvilinear and long-range channels by using high-order statistics for pattern reconstruction. As a result, the computational burden is heavy, and sometimes, the current algorithms are unable to be applied to large-scale simulations. With the continuous development of hardware architectures, the parallelism implementation of MPS methods is an alternative to improve the performance. In this chapter, we overview the basic elements for MPS methods and provide several parallel strategies on many-core architectures. The GPU-based parallel implementation of two efficient MPS methods known as SNESIM and Direct Sampling is detailed as examples.",signatures:"Tao Huang and Detang Lu",downloadPdfUrl:"/chapter/pdf-download/51611",previewPdfUrl:"/chapter/pdf-preview/51611",authors:[{id:"180203",title:"Dr.",name:"Tao",surname:"Huang",slug:"tao-huang",fullName:"Tao Huang"},{id:"183497",title:"Prof.",name:"Detang",surname:"Lu",slug:"detang-lu",fullName:"Detang Lu"}],corrections:null},{id:"50956",title:"Numerical Simulation of Laser Processing Materials: An Engineering Approach",doi:"10.5772/63945",slug:"numerical-simulation-of-laser-processing-materials-an-engineering-approach",totalDownloads:2209,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"The following chapter aims at giving an overview of the use of numerical simulation in the field of laser processing. Indeed, the past two decades saw an increasing demand for lasers in various areas such as healthcare, microelectronics, cartography, optoelectronics, aeronautics, etc. Thus, the comprehension of the laser-material interaction and the removal mechanism became primordial to predict and improve the efficiency of a process. After a nonexhaustive literature review, two simulation approaches (Finite Element and Design Of Experiment, DOE) will be presented to demonstrate the importance of numerical simulation in laser applications.",signatures:"Guillaume Savriama and Nadjib Semmar",downloadPdfUrl:"/chapter/pdf-download/50956",previewPdfUrl:"/chapter/pdf-preview/50956",authors:[{id:"26521",title:"Prof.",name:"Nadjib",surname:"Semmar",slug:"nadjib-semmar",fullName:"Nadjib Semmar"},{id:"179922",title:"Dr.",name:"Guillaume",surname:"Savriama",slug:"guillaume-savriama",fullName:"Guillaume Savriama"}],corrections:null},{id:"51275",title:"Mathematical Modeling for Nanofluids Simulation: A Review of the Latest Works",doi:"10.5772/64154",slug:"mathematical-modeling-for-nanofluids-simulation-a-review-of-the-latest-works",totalDownloads:2988,totalCrossrefCites:24,totalDimensionsCites:43,hasAltmetrics:0,abstract:"Exploiting nanofluids in thermal systems is growing day by day. Nanofluids having ultrafine solid particles promise new working fluids for application in energy devices. Many studies have been conducted on thermophysical properties as well as heat and fluid flow characteristics of nanofluids in various systems to discover their advantages compared to conventional working fluids. The main aim of this study is to present the latest developments and progress in the mathematical modeling of nanofluids flow. For this purpose, a comprehensive review of different nanofluid computational fluid dynamics (CFD) approaches is carried out. This study provides detailed information about the commonly used formulations as well as techniques for mathematical modeling of nanofluids. In addition, advantages and disadvantages of each method are rendered to find the most appropriate approach, which can give valid results.",signatures:"Mohammad Reza Safaei, AminHossein Jahanbin, Ali Kianifar,\nSamira Gharehkhani, Akeel Shebeeb Kherbeet, Marjan Goodarzi\nand Mahidzal Dahari",downloadPdfUrl:"/chapter/pdf-download/51275",previewPdfUrl:"/chapter/pdf-preview/51275",authors:[{id:"178854",title:"Dr.",name:"Mohammad Reza",surname:"Safaei",slug:"mohammad-reza-safaei",fullName:"Mohammad Reza Safaei"},{id:"179809",title:"Dr.",name:"Mahidzal",surname:"Dahari",slug:"mahidzal-dahari",fullName:"Mahidzal Dahari"},{id:"179813",title:"MSc.",name:"Marjan",surname:"Goodarzi",slug:"marjan-goodarzi",fullName:"Marjan Goodarzi"},{id:"183092",title:"Dr.",name:"Akeel",surname:"Kherbeet",slug:"akeel-kherbeet",fullName:"Akeel Kherbeet"},{id:"187529",title:"Dr.",name:"Aminhossein",surname:"Jahanbin",slug:"aminhossein-jahanbin",fullName:"Aminhossein Jahanbin"},{id:"187531",title:"Dr.",name:"Ali",surname:"Kianifar",slug:"ali-kianifar",fullName:"Ali Kianifar"},{id:"187532",title:"Dr.",name:"Samira",surname:"Gharehkhani",slug:"samira-gharehkhani",fullName:"Samira Gharehkhani"}],corrections:null},{id:"51919",title:"Application of Phase-Field Method to the Analysis of Phase Decomposition of Alloys",doi:"10.5772/64153",slug:"application-of-phase-field-method-to-the-analysis-of-phase-decomposition-of-alloys",totalDownloads:1716,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter is focused on the application of the phase-field method to the analysis of phase decomposition during the isothermal aging of alloys. The phase-field method is based on a numerical solution of either the nonlinear Cahn-Hilliard equation or the Cahn-Allen equation. These partial differential equations can be solved using the finite difference method among other numerical methods. The phase-field method has been applied to analyze different types of phase transformations in alloys, such as phase decomposition, precipitation, recrystallization, grain growth, solidification of pure metals and alloys, martensitic transformation, ordering reactions, and so on. One of the main advantages of phase-field method is that this method permits to follow the microstructure evolution in two or three dimensions as the time of phase transformations progresses. Thus, the morphology, size, and size distribution could be determined to follow their corresponding growth kinetics. Additionally, the evolution of chemical composition can also be followed during the phase transformations. Furthermore, both Allen-Cahn and Cahn-Hilliard equations can be solved simultaneously to analyze the presence of ordered phases or magnetic domains in alloys.",signatures:"Erika O. Avila-Davila, Victor M. Lopez-Hirata and Maribel L.\nSaucedo-Muñoz",downloadPdfUrl:"/chapter/pdf-download/51919",previewPdfUrl:"/chapter/pdf-preview/51919",authors:[{id:"76298",title:"Dr.",name:"Víctor Manuel",surname:"López-Hirata",slug:"victor-manuel-lopez-hirata",fullName:"Víctor Manuel López-Hirata"}],corrections:null},{id:"51047",title:"DEM Simulation Based on Experimental Testing",doi:"10.5772/63889",slug:"dem-simulation-based-on-experimental-testing",totalDownloads:1489,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The paper examines several key aspects of soil morphology, namely experimental and numerical test validation and compression test result dependency on changing morphology parameters. The present chapter describes investigation of soil morphology parameters influence for numerical compression properties with evaluation of examined sand engineering geological conditions. The main objects of research: morphology parameters investigation with view analysis program and scanning electronic microscope; experimental soil compression testing; numerical soil compression simulation and results validation with experimental ones. The primary purpose of this paper is therefore to investigate the influence of morphology parameters on sand mechanical properties and to determine optimal quantity of spheres for single‐particle shape subscription.",signatures:"Dr Šarūnas Skuodis",downloadPdfUrl:"/chapter/pdf-download/51047",previewPdfUrl:"/chapter/pdf-preview/51047",authors:[{id:"179990",title:"Dr.",name:"Šarūnas",surname:"Skuodis",slug:"sarunas-skuodis",fullName:"Šarūnas Skuodis"}],corrections:null},{id:"51503",title:"Impact of Fluid Flow on Free Radical Polymerization in a Batch Reactor",doi:"10.5772/64156",slug:"impact-of-fluid-flow-on-free-radical-polymerization-in-a-batch-reactor",totalDownloads:1482,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this work, the mixing process on a batch reactor is analyzed for the thermal synthesis of poly(acrylamide-co-sodium 2-acrylamide-2-methylpropane sulfonate) initiated by ammonium persulfate. 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\r\n\tThe immense benefits of tunnels can be readily recognized and have led to great strides in areas such as transportation, stormwater drainage, waste disposal, and pipeline networking. Requirements for tunnels depend on the intended functions and factors such as size, depth, configuration, and underground conditions. Achieving the desired functionality is usually multifarious and complex due to the range and interrelationships of the myriad of issues that must be taken into account.
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These children experience greater difficulties in their social relationships, often suffer from loneliness and are often victims of aggression or rejection from their peers (Last, 1993; March, 1995; Vasey & Dadds, 2001; Morris & March, 2004). Children who suffer from an anxiety disorder can experience fatigue, difficulty concentrating, irritability, and school refusal (Dadds & Barrett, 2001). They are also more susceptible to psychosomatic illnesses and more likely to use health care services (Morris & March, 2004). Along with their distress and their vulnerability to stress, they are more at risk of developing early drug addiction problems or attempting suicide (Morris & March, 2004). Finally, there is a high probability that during adolescence or adulthood they will develop anxiety disorders that will compromise their personal and social lives (Costello et al., 2003; Hirshfield et al., 2008).
The positive results obtained by teaching cognitive-behavioral techniques for anxiety management to young children (Kendall, 1994; Kendall et al., 1997; Barret et al., 2001; Compton et al., 2004; Cartwright-Hatton et al., 2004; Hirshfeld-Becker et al., 2010) militates for the feasibility to develop attitudes and behaviors that could be protective factors for anxiety disorders. Some emotion regulation skills seem to play a key role in the capacity of children to manage their anxiety. These skills include knowledge about physiological reactions to anxiety and stress, the capacity to identify the source of emotion dysregulation and to verbalize their emotions, the ability to restructure dysfunctional thoughts in order to generate emotions that stimulate productive action, the use of problem-solving strategies or of personal support networks, and the capacity to gradually expose oneself to threatening situations (e.g. Miller et al., 2010; Stallard, 2010).
When it comes to developing prevention program, the question arises regarding the relevance of providing prevention interventions to all children or only to children who are at risk (Lowry-Webster et al., 2001). We believe that some cognitive and behavioral characteristics of children who are more vulnerable to anxiety and that are common amongst all anxiety disorders should form the basis and pedagogical strategies of prevention programs. Underlying cognitive characteristics that transcend all anxiety disorders rest on the association between fear and situations that are: perceived as threatening, and / or unexpected, and / or uncontrollable and / or where the child has a poor sense of perceived self-efficacy to cope with the situation. In addition, there is a common transdiagnostic behavioral characteristic that must also be targeted in the prevention of anxiety disorders: avoidance of threatening stimuli (also referred to as safety seeking behaviors). These cognitive and behavioral characteristics are often expressed by children through excessive worries, anxiety sensitivity, avoidance, panic attacks or communicating to adults their feeling that they can’t face a problem or a situation (Ollendick & March, 2004).
Learning anxiety management skills could also be of benefit for the majority of children, not only those at risk for a disorder (Hiersfeld-Becker et al., 2002; Lowry-Webster et al., 2001; Stallard, 2010). Anxiety is a normal emotional reaction and most children could benefit from better emotion regulation skills. In addition, many children consider their normal fears as disruptive of their daily activities (Muris et al., 2000). Over the course of their development, all children are faced with various anxiety-producing situations that test their capacity for adaptation (Dacey & Fiore, 2000). These episodes could be related to difficult living conditions (e.g., poverty), a developmental crisis or specific unanticipated events (Becker & Chorpita, 2008). In essence, a universal primary prevention program could be relevant for all children and foster their capacity to adapt to daily problems (Lazarus & Folkman, 1984; Hardy et al., 1993).
Stories and metaphors are already used in treatment programs for anxiety disorders to help adults understand their reactions in order to develop new attitudes and behaviors (Otto, 2000). Using books to teach cognitive-behavioral techniques has also been proven useful with depressed adolescents (Ackerson et al., 1998; Scogin et al., 1990) and with individuals suffering from panic disorders (Gould et al., 1993; Wright et al., 2000). Some books may be self-treatment manuals or simply provide support for the intervention of the therapist. Dominique’s Handy Tricks used the latter approach, in which stories about problems in school or at home provide support for a workshop leader to teach relevant anxiety management techniques.
Building a universal and primary prevention program around the use of realistic stories is based on the assumptions that it could: (a) provide meaningful illustrations of key concepts and adaptive behavior, (b) facilitate exchanges with and between participants, (c) normalize emotional reactions to stressors, (d) put into words what the children experiences daily, and (e) offer the opportunity for anxious children to share apprehensions or worries without having to disclose details of events that occurred to them.
The events faced by Dominique and his friends highlight stressors encountered among school-age children, such as having academic problems, being judged by others, being separated from their parents or being ridiculed. Various useful cognitive and behavioral strategies can also be illustrated, such as facing fears, coping with bullying, or confide in adults. The stories also provide non-threatening means of discussing subjects that, if dealt with directly, could embarrass children suffering from an anxiety disorder, induce emotions or reveal confidences that could become detrimental to them (Milich et al., 1992).
In summary, the prevalence of anxiety disorders in children and the fact that all children can benefit from anxiety management techniques lead to the development of a universal prevention program that do not target dysfunctional anxiety up front. The originality of the program rests on the use of storybooks depicting situations that are known stressors for many children, normalize their concerns and set the stage to provide information and exercises to learn the typical cognitive-behavioral techniques used to cope with everyday life stressors as well as anxiety disorders.
The program
Dominique\'s stories are about situations that are meaningful for elementary school-age children (9 to 12 years old). They were written because they address significant school-age children concerns and worries. Each one explains daily stressors related to the main problem in the book. For example, the book targeting academic problems lead to arguments with parents, worrying about an imminent report card, criticism from the teacher, being made fun of by others, etc. Each of the stories describes typical interactions around the problem, with the adult and child characters adopting attitudes and behaviors that are sometimes appropriate, sometimes not. In the story scenarios, the various characters also express a variety of emotions and ways of thinking as they deal with problems. As part of the program, the aim of these stories is to support the teaching of anxiety prevention and emotion regulation skills by illustrating key concepts or behaviors.
In order to ensure the educational quality of the stories, they were developed by combining deductive and inductive methods. Triangulation of qualitative and quantitative data was performed along the qualitative research methodology proposed by Mayer and Ouellet, 1991). For example, the story describing the daily life of a little girl living with an alcoholic mother (used in Session 9) was produced according to the following steps. First, a literature review provided answers to questions such as: What specific everyday problems do children living with alcoholic parents encounter? What are the attitudes and behaviors of peers and adults associated with this family situation? What behaviors are most often associated with resilience? Second, data was collected from about twenty children and their alcoholic parents in order to ensure that the theoretical content was relevant. A draft version of the scenario was then submitted to the same individuals (children and adults), acting as an advisory committee. Focus groups were used to gather primary information on the realism of the narrative, its pertinence, the quality of the information and the accessibility of the language used. Finally, the revised story was submitted to a sample of senior elementary school students. These students filled out a questionnaire of about ten questions aimed at determining the pertinence and educational qualities of the narrative. These questions dealt with how appealing the stories were, their linguistic clarity and the nature of the messages. Once this final verification was complete, the story was illustrated and published. In summary, the qualities of each of the stories (realism, pertinence, accessibility of the language) were subject to field testing prior to their use in the program.
The general approach for teaching the cognitive-behavioral techniques in this workbook follows a sequence where participants help Dominique or his friends to identify anxiety-producing situations and adopt appropriate strategies to deal with them. Each session highlights one or two specific cognitive or behavioral strategies to reduce or cope with anxiety. These effective coping solutions are called Dominique’s handy tricks and homework are given to apply and master these skills at home in stressful situations called “personal challenges”.
Many of the exercises in the children\'s workbook were designed along the same lines as those used in treatment programs for anxiety disorders for children (e.g., Friends and Coping Cat, Kendall, 1992). However, our original approach gives a different angle to these exercises. As universal coping strategies, they are applied in the workshops in reference to a precise section or illustrations in the books. This learning approach is fun and stimulating for children, does not require children to experience an anxiety disorder in order to apply the strategies, as well as favoring instructive interactions between the group and the workshop leader. The core skills addressed in the entire program are (see Table 1): (a) understanding the relationship between stressors, thoughts, emotions/anxiety and actions; (b) detecting early signs of anxiety; (c) cognitive-restructuring; (d) exposure, (e) problem solving and (f) using the social network. Different techniques are used to teach the strategies to children, such as illustrations of key concepts, schematic representation with icons to differentiate stressors, thoughts, emotions and actions, asking children to write in bubbles what a character is thinking or to draw information, etc. The manual and all key concepts are illustrated (see Figure 1).
Excerpts from sections of the children workbook illustrating: (a) key concepts in the program (stressors, thoughts, emotions and actions), (b) the role of appraisal and (c) the introduction of cognitive restructuring to counter dysfunctional thoughts.
Summary of the program’s weekly skills, aims and stressors.
This document presents the program and explains different aspects of anxiety, its mechanisms and its consequences. Parents also find information on daily stressors children often meet, children’s potential reactions and general recommendations to help their child cope with anxiety-producing situations. The parents also have access to the story books and to supportive recommendations related to the topic addressed in the story. In addition, they are encouraged to follow their child’s progress. Some activities requiring the cooperation of the parents are also explained.
Designed specifically for the workshop leaders, it contains basic notions on the nature of anxiety and the symptoms associated with anxiety management problems. It summarizes the cognitive-behavioral theoretical principles that form the basis of the program and includes explicit details on the aims and activities of each workshop. The general transdiagnostic model for the development of an anxiety disorder proposed that temperamental / genetic risk factors, combined with environmental / familial factors can lead to a greater susceptibility to stressors due to dysfunctional cognitive and behavioral characteristics (see section 1 above). Among susceptible children, various life events could lead to the development of different anxiety disorders, depending on what is associated with threat and avoidance.
Information related to the conduct of the workshops is summarized in Table 1 above. The ten workshops in the program last about seventy-five minutes each. The workshop usually begins with a review of what was learned the week before and the homework exercises done during the week. The reading of the story then follows, lasting about twenty minutes. The learning activities deal first with the identification of everyday stressors related to the workshop themes (e.g., receiving a report card, in the case of academic stress), followed by exercises designed to develop the skills targeted for each session (see Table 1). At this stage, it is important to recall that for the purposes of normalization in the program (as in the text above) the term
Dominique handy tricks program has been implemented with 46 children with the hope of improving their feelings of self-efficacy to cope with stressors, reducing anxiety sensitivity and anxiety symptoms and fostering the development of problem-solving skills. After approval from the University of Quebec in Outaouais’ Ethics in Research Committee, the program was delivered in the schools according to the manual described in this chapter. For ethical concerns about not providing effective treatment to children that could be screened as potentially severe enough to warrant a treatment, it was decided to exclude and refer to treatment those who would obtain a clinically significant score on the Child Behavior Checklist (global score > 75), on the Screen for Child Anxiety Related Emotional Disorders (global score > 60) or on one of the clinical outcome measure. An initial sample of 59 children were recruited, 55 started the program and 9 did not completed the post-program assessment. Participants were aged between 9 to 12 years old and randomly assigned to a waiting list (and received the program later) or to receive the program. Quantitative analyses of outcome results are being conducted on the Coping Scale for Children and Youth, the Perceived Self-efficacy Towards Problem-solving Scale, the Childhood Anxiety Sensitivity Index, the Multidimensional Anxiety Scale for Children, and the Fear Survey Schedule for Children-Revised and will be the focus of a future article.
To complement the description of the program detailed in this chapter, this section will report on
The program was provided for free and on a voluntary basis. Yet, the research agenda required children and parents to take part in long assessment sessions, which raised worries about the feasibility of a primary prevention program. Our concerns regarding recruitment proved to be unfounded. The program was accepted enthusiastically by those working in the schools, as it was by parents. Both groups expressed on several occasions their enthusiasm to see a program targeting stress experienced by children. In addition, the application of the program took place without any substantial attrition problem (only 4 dropped-out during the program). Very few children missed even one session. Answers from children and the focus group with workshop leaders confirmed that the stories told in each session were an important motivating element for the attendance and participation of the children in the workshops, even for the more delicate topics such as alcoholism and sexual abuse.
Comments from participants confirmed children\'s interest in the exercises as they appear in the children\'s workbook. Based on discussions in the focus group, such a program should be applied with some flexibility to adapt the use of these exercises to the characteristics of the participants. In their original form, most of the workshop exercises were designed to be done in discussions or in paper-and-pencil activities. This approach appeared to be particularly well suited to girls but the focus group revealed it may be less suitable for boys, who were more receptive to a presentation of content in the form of interactive activities. These observations supported our impression about the usefulness in the
Comments from the participants highlighted that planning and carrying out take home activities represented a challenge for the children. Since these exercises are essential for the generalization of recently acquired skills learned learn in session to practical issues occurring in their own lives, compliance with homework deserves to be mentioned. Doing the weekly exercises requires a high level of motivation. However, since the program was not intended for, nor delivered to, a clinical population, the children motivation vanished rapidly once they had left the session. They were not highly motivated to initiate exercises to master their new coping behaviors. This may have contributed to the fact that some of them invested little time in the homework or sometimes failed to complete the exercises in the workbook.
It is reasonable to believe that take home activities could also be perceived as a burden given their already occupied academic agenda and their school homework. Although behavioral changes require involvement and practice, in primary prevention programs it may be more difficult to enroll children to invest in practicing behavior changes if the motivation is extrinsic and rather hypothetical compared to children who want to stop suffering from an anxiety disorder. Even though participants confirmed weekly that the exercises in their workbooks had been completed, it is difficult to ensure that the exercises have not been done hastily or at the last minute. Innovative approaches could be developed to increate adherence to homework, such as on-line contact with the workshop leader during the week (to notify him or her that the exercise has been done) or the use of a buddy system (two children supporting each other in doing the application exercises) as is the case in other programs such as Coping Cat (Kendall, 1992).
The qualitative data also documented a significant and positive impact when parents agreed to get involved and followed weekly the development of the child’s exercises in the workbook. Interestingly, we observed that such parental involvement was not without its disadvantages. Many children did not want their parents to look at their exercise workbooks because they felt the contents were personal. This calls into question the relevance and depth of parental involvement in primary prevention program for internalizing disorders. One might posit that parental involvement could just as well create resistance as it could provide positive support to the children\'s learning.
Participation of at least one of the parents in the three information sessions provided during the program was very low. Family members of less than 15% of the participants attended these information meetings, which were held in the evening to accommodate them. The workshop leaders have, however, reported positive comments from the parents who did attend. Parents reported that the stories facilitated communication with their children and suggested positive attitudes to adopt. The stories also allowed discussing openly about potential anxiety reactions parents had observed in their children following stressful events such as divorce or learning difficulties. Discussions with parents were an opportunity to provide information and alleviate their own worries about children’s problems. In spite of these positive observations, the low attendance to the meetings raises the question of the feasibility to involve at least one parent from each family in a primary prevention program. When their child is not suffering from an anxiety disorder, parents may prioritize other family needs instead of attending to meeting in a prevention program. The impact of including or not the parents in the program on children’s learning remains however unclear and questionable (Hudson et al., 2008).
The fact that workshops sessions were held in schools facilitated that professionals and teachers put pressure for the inclusion of children with externalized disorders in a universal primary prevention program for anxiety disorders. This reaction was predictable insofar as resources for children in difficulty are scarce. The qualitative data collected confirmed the importance of caution with respect to the inclusion in the groups of children with behavioral disorders, most notably hyperactivity. Many exercises in the program require self-observation by the children and a capacity to identify their feelings or recognize their own reactions to events. Some children who openly claimed to be suffering from attention deficit and hyperactivity disorder appeared to have, in addition to their behavioral problems, difficulties with introspection, which may have complicated their learning and hindered the functioning of the group. In one workshop group, where three children claimed suffering from attention deficit with hyperactivity disorder, the participants became very disruptive in several sessions, requiring the workshop leader to work harder to manage the group. Although our observations about attention deficit and hyperactivity are based on a small number of cases and were not systematically gathered, they converge with the results of studies showing that learning cognitive techniques is a significant challenge for these children (Abikoff, 1991). This possibility illustrates the importance of careful selection of the children and of the make-up of the groups of children. A universal primary prevention program for anxiety disorders is not a complement for the treatment of ADHD. It is not a free treatment for anxiety disorders either. School staff and sources of referral must understand that primary prevention is meant to be implemented before emotional and behavioral problems occur.
The qualitative information collected during and after the implementation of the program should guide further trials of the program. They have raised some shortcomings that will be taken into consideration when revising the program for a new trial. More schools have expressed a desire to implement the program and several pilot projects for new trials are considered. Results of the outcome trial are expected soon, yet some of the less tangible benefits of a universal program have been already observed, such as heightened awareness about anxiety and its consequences, early detection of children at high risk for the development of internalized disorders, and the promotion of psychological services to prevent and treat anxiety disorders. It is hoped that a better understanding of the nature of anxiety and its disorders could contribute to more supportive behaviors from classmates and adults.
The resources allocated for the prevention and treatment of externalized disorders, such as ADHD, are far greater than those allocated for the prevention of internalized disorders. Dominique’s handy tricks program can contribute to the promotion of knowledge about anxiety disorders, which are the most prevalent disorders in this age group (Merikangas et al., 2009). Adherence to universal prevention programs and sustained efforts to master new skills may be challenged by motivational issues in children and their parents. New methods that rely on computer technologies (Bouchard, 2011) may increase children’s interest toward the use of CBT treatment and prevention tools. In the meantime, it is hoped that by focusing on strategies to cope with various stressors instead of dysfunctional anxiety, Dominique’s handy tricks program will stir interests in children.
This study was funded by a joint research grant from the
The 2030 Agenda adopted by the United Nations General Assembly in 2015 and defined by the subscribing members as “a plan of action for people, planet and prosperity” has identified 17 goals in order “to take the bold and transformative steps which are urgently needed to shift the world onto a sustainable and resilient path” [1]. The goals refer to different fields of social and economic development and must be addressed through an integrated approach, aimed at achieving sustainable progress. The United Nations Inter Agency Expert Group on SDGs (UN-IAEG-SDGs) has developed 169 global targets, and 234 indicators that have to be monitored—as a global reference framework—in the period 2015–2030. In particular, Goal 11 deals with the urban sustainability issue and emphasizes how cities play an essential role in achieving the Sustainable Development Goals since half of the world population and three-quarters of the European population live in urban areas. All over the world, cities are responsible for the largest share of energy consumption and carbon emissions, for the growing pressure on the environment and the related public health issues [2].1 The governance of urban space, therefore, represents a crucial development factor capable of posing worldwide challenges and opportunities. Several aspects must be considered in a systemic, inclusive and integrated way to ensure that cities thrive in a sustainably. It is vital to ensure that the population living, working or passing through the city has access to mobility, quality housing and safe conditions, both in terms of structural stability of public and private buildings and infrastructures, and protection from crime, violence and harassment.
Moreover, the presence of green spaces and public spaces, the protection of the cultural and natural heritage, the redevelopment of run-down areas, the relationship between the city and peri-urban and rural areas are as crucial as the aspects mentioned before. Yet, to be able to proceed in this direction it is essential to work according to an integrated approach that addresses the physical and structural aspects of the city, as well as the intangible ones. These last ones range from social and cultural aspects to those related to work and local economies, within broader processes that activate latent or already existing projects and social energies, which very often require policies from below. This process has already been triggered with the 2007 Leipzig Charter together with the related integrated urban development strategies that at a national, regional and local level focused on the cultural and architectural qualities of cities, conceived as strong tools for social inclusion and economic development useful to positively affect economic prosperity, social balance and the environment, within a coordinated process between spatial, sectorial and temporal aspects of urban areas. This process continued with the Toledo Declaration of 2010, which suggested a transversal, multidimensional and holistic design approach to achieve multiplying, complementary and synergistic effects, solving conflicts and finding the right balance between temporal (short, medium, long term) and spatial (region, metropolitan area, city, neighborhood) needs. These recommendations are reiterated and strengthened in the newborn Renovation Wave strategy, part of the European Green Deal promoted by Brussels which places the redevelopment of the building stock in a relevant position as an essential measure for decarbonization and reduction of emissions and as a tool for boosting the economy and European competitiveness. The new Renovation Wave strategy aims to double the urban regeneration rate, currently at 1%. According to Brussels estimates, a significant share of 35 million renovated and regenerated buildings could be reached by the end of the decade [3]. This situation would lead not only to significant ecological and energy benefits, but also to social ones considering that a recent report on sustainable recovery asserts that building renovation offers the greatest employment leverage: 12–18 local jobs for every million investments. This potential would create by 2030 as many as 160,000 new jobs in the EU construction sector [4].
More specifically, the Renovation Wave strategy will prioritize action in three areas: decarbonization of heating and cooling; tackling energy poverty and energy inefficiency; renovation of public buildings (schools, hospitals and offices). It will do so through several measures that make energy redevelopment operations easier and faster.2 “The green recovery starts from home,” said Energy Commissioner Kadri Simson, “with this initiative we will face the numerous obstacles that today make the restructuring complex, expensive and slow, slowing down many necessary interventions” [5].
Furthermore, the recent COVID-19 emergency sets before us a new vision of residential heritage, having highlighted its limits—in particular those of the public residential heritage. Therefore, urban regeneration offers the opportunity to rethink housing models. Today, more than ever, the challenges posed by epidemiological and climate changes bring to light more intangible realities which are more oriented towards generative social action. These realities require the involvement of actors, not only of the construction sector but also of the local community through the implementation of complex and long-lasting social projects, which must be designed to support first of all the most vulnerable groups.
In Italy, the evolution of the concept of urban regeneration can be re-read within the relevant legislation, that marks the transition from the concept of recovery to the concept of rehabilitation, within the legislation presented and approved in the period between the 90’s and the early 2000s. Indeed, national legislation moves from integrated intervention programs to urban redevelopment programs (L. 179/1992); from urban recovery programs (L. 493/1993) to district contracts (D.M. n. 1071–1072, del 1° dicembre 1994); from urban regeneration and sustainable development programs (D.M. dell’8 ottobre 1998) to urban rehabilitation programs (L. 166/2002).
It is precisely the building and urban rehabilitation programs (L. 166/2002) that introduce, alongside the concept of transformation of physical space, that of performance, especially linked to the concept of efficiency, taking into consideration also economic and social issues, including physical deterioration. In 2015, all these experiences led to the
In recent years, several regional regulations in the field of urban planning and construction have been introduced within the framework of urban regeneration with a strategic vision of territorial planning, implemented through complex plans and programs. Many regional regulations reveal that the regulatory concept of urban regeneration differs more and more from that of building recovery and urban planning, and is gradually including complex actions for the urban, environmental and social rehabilitation of degraded urban areas. Examples are the regional law of Emilia-Romagna (L.R. n.24, 21 dicembre 2017) on the protection and use of the territory, the regional law of Tuscany (L.R. n.65, 10 novembre 2014), which lays down rules for the government of the territory, the regional law of Lazio, (L.R. n.7, 18 luglio 2017) containing regulations for urban regeneration and building recovery, just to name a few.
The law L. n. 158 dell’8 ottobre 2017—containing measures for the support and enhancement of small municipalities, as well as regulations for the redevelopment and recovery of their historic centers—complies with the goals mentioned above, where the concept of regeneration takes on a connotation of territorial and environmental protection and where small municipalities are recognized as a resource due to their role as a territory presidium, especially about their role in contrasting hydrogeological instability and in preserving and protecting common goods.
Urban regeneration, which is gaining an important space in regional legislation, still struggles to find a precise definition in the national one, where it is addressed as an emergency measure by the D.L. 18 Aprile 2019, n. 32—“
In this context marked by a European policy strongly focused on energy saving and consumption reduction, the existing building stock and its redevelopment play an important role, especially the energy requalification of public housing (ERP) [6]. By public housing we refer to the residential real estate built, directly or indirectly, by the State, to be assigned, at particularly good economic conditions, to citizens with low incomes or who find themselves in poor economic conditions. The law regulating public housing identified three areas of intervention onto which allocate the available economic resources: subsidized housing of exclusive public ownership, assisted housing in property and/or with controlled rent and housing with agreements on surface or property rights. The fact that the European public housing heritage is plentiful and assorted, is a clear expression of the cultural and economic differences of our continent. In Europe, a significant share of the housing stock was built in response to the demand for housing following the Second World War. To date, more than 220 million buildings, representing 85% of the European building stock, were built before 2001. The majority of them are not energy efficient, as a result of old technologies and bad insulation—and account for around 40% of total European energy consumption and 36% of greenhouse gas emissions [3]. The physical (technical-functional), social and economic conditions of degradation that characterize the public building heritage demand the identification of immediate intervention strategies. The aim of the research is to show how certain strategies, in particular bioclimatic, modular and low-cost ones applied to the small building scale, can become the main tools for rehabilitating relevant parts of the contemporary city. For this reason, the research work described in this essay aims to give back urban quality to the suburban fabric which hosts public residential buildings through an architectural, energetic, bioclimatic and environmental requalification. This operation provides an attempt to read the peripheral palimpsest, through punctual and diversified interventions involving the description of the physical space, of the biophysical one and the understanding of bioclimatic phenomena, which cannot be separated from the understanding of the social space. Throughout the research, the role of the architect has been reconsidered as a social role that requires the ability to listen, interpret and explore the peripheral space, with the intent of setting shared and experimental assumptions to which reference can be made to overcome with the method and analytical scientificity the contradictions and conflicts of extended urban peripheries. Every overall transformation program, each detailed project is declined in this sense by associating several reinterpretations of the space and considerations on the possible scenarios of transformation, to develop, through a critical synthesis, an innovative conception of urban peripheral environment. This environment is meant to dialog with the consolidated city and to connect the redevelopment process to the cultural, social and technological transformations that affect society and urban form and that emphasize the need for new ideas, innovative models and relevant examples.
Overall, the analyses and evaluations of this research work start from the identification of the problems within the analytical phase and then explore the feasibility of intervention scenarios that can help to achieve greater urban quality. At the heart of the work, there are three research survey directions concerning:
The ability to measure oneself with the characters of the places and the territory;
An environmentally sustainable and energetically and ecologically efficient transformation-development;
The reconstruction-enhancement of the public space.
Given the first research direction, the operational strategic lines address:
The broadening of the analysis framework concerning the anthropic, biophysical and bioclimatic factors to support the development of meta-project scenarios;
The optimization the control system of environmental components in the development phase of the intervention program-project;
The maximization of instrumental skills to verify the quality and eco-efficiency levels of the architectural project and urban reality;
The development of verification steps concerning the different degrees of quality and environmental sustainability to be assigned to the different phases of the project;
The optimization of systems for monitoring and controlling the behavior of outdoor, intermediate and confined spaces.
Regarding the implementation of the second research axis, the following operational strategic lines have been identified:
to optimize the specific conditions of mobility-transport connecting the periphery with the consolidated city;
to enhance-protect the local landscape-vegetation assets;
to enhance the soil conditions in terms of site orography, lithology and stratigraphy;
to optimize local hydrogeological conditions, considering rainwater runoff;
to introduce morphological-typological solutions aimed at integrating residential functions and extra-residential activities;
to organize and manage the material, energy and information flows at the district level;
to introduce innovative building solutions aimed at energy and ecological efficiency.
Finally, the third research axis aims at:
controlling and enhancing greenery in its role as a filter between environmental factors and functionality of outdoor spaces;
using outdoor spaces for meeting and social occasions within the general reorganization of paths and mobility;
enhancing the relationship between mobility, vegetation, bioclimatic and urban furniture in the design of in-between outdoor spaces;
maximizing psycho-perceptive comfort conditions related to the morphology of the intermediate outdoor spaces;
maximizing energy and ecological efficiency of the public space.
The case studies illustrated in the essay focus on the analysis and regeneration of two types of ERP multi-storey buildings,
The two-building typologies are taken into consideration using their similarities from an administrative and legal point of view and of their differences on a typological and environmental level and about their relationship with the context (Figure 1). The case studies analyzed are chosen to be representative of the respective building typology which recur in the ERP Roman context. The choice to study buildings located in peripheral areas is linked to the desire of investigating distressed urban areas [7], areas where it is even more urgent and necessary to intervene and where regeneration processes have a reorganization potential that transcends the architectural level and bring along positive effects on the socio-economic conditions of the inhabitants.
Territorial framework: two ERP case studies in Rome.
Specifically for the tower high rise building typology, an ERP condominium was identified—part of a plot of four twin condominiums—in the north-western suburbs of Rome, XIII–XIV municipality, while for the linear multi-storey building typology an ERP condominium was identified—which is repeated 18 times with different orientations according to
The methodology adopted in this research allows, once the different hypotheses have been identified, to evaluate both the technical (energy savings that would result) and economic feasibility, as well as to verify the overall compliance with national and local regulations.
The methodological approach followed for both case studies provides for an analysis of the context and the current situation of the buildings starting from a territorial and urban framework with a specific focus on mobility, facilities and greenery. Subsequently, demographic, socio-economic and housing demand surveys were carried out. Ultimately, an environmental and micro-climatic analysis both of the entire context and the building under examination was carried out and finally, the architectural and technological components underwent a thorough examination. The aim is to detect critical issues at the building and housing level and to subsequently define the typological and functional program and the overall intervention strategies in line with technological and environmental requirements. The definition of the general morphological-functional characteristics of the intervention about the interaction model between microclimatic factors and the context led to the preliminary design. This initial design stage was developed according to studies and technical validations set at a meta-design level, followed by a functional study and the reinterpretation of housing schemes and supplementary facilities, according to the social demand. At last, a summary report on the identified demand/performance system was drafted: clarification of the environmental technological requirement system and its related design choices. The different strategies and design solutions underwent a definitive design elaboration of the building system and its subsystems and components in line with the environmental context and their interrelations with the transformations induced by the intervention.
The Torrevecchia district (Figure 2), built with funding from law L. n. 584 of 1977, is an area of approximately 24 ha with 1074 accommodations for 3600 inhabitants located in the north-west area of Rome in the Primavalle district, XIII–XIV municipality. It is owned and managed by the autonomous institute of popular housing (IACP), a specific Italian institution to promote, build and managing public housing to assign to citizens on low income rented at controlled rates. The architects P. Barucci, L. Passarelli and M. Vittorini were in charge of its design and execution. Until the 1960s Torrevecchia was part of the
Aerial view of Torrevecchia district (source: Google Earth).
The plano-volumetric scheme is developed around a central square defined by four 15-storey high tower buildings (76 apartments) on which a group of offices and a bar overlook. Long 4/5 storey buildings (192 apartments) branch off from the central square with three levels of housing and a ground floor meant for shops, which were never realized.
Thanks to a progressive series of shifts, these volumes tend to spread out towards the extremity of the area thus creating in-between them two green spaces large enough to host respectively a small public park and a sports field. Car parking spots are located on the external side of the linear storey buildings, thus remaining outside of the central green areas defined by the building volumes.
Overall, the architectural solutions adopted in the different buildings are rather simple and they all respond to the constraints set by the standards imposed by law and by the economic means: prefabricated concrete panels and ribbon windows with metal frames.
The IACP complex is commonly known as the “Bronx” due to its architectural aspect (poor architectural-spatial, environmental and energy quality of the buildings) and the socio-economic conditions of the area. The complex is strongly marked by economic precariousness, by the absence of public spaces and areas for meeting and socializing, by the absence of life and services at ground zero, and eventually by lack of maintenance and building degradation.
According to 2011 ISTAT census data (the Italian National Institute of Statistics, which is the main producer of official statistics in Italy), one out of four residents appear to be unemployed and 9 out of 10 people have reached a level of education below the middle school. The social hardship index, which provides a measure of the possible social-occupational drawbacks, is among the highest in Rome.
An analysis of mobility and facilities (Figure 3) reveals a lack of good quality common spaces, a poor and inefficient transport system that makes nearby facilities not accessible. The Battistini metro station (line A), which connects the district with the city centre, is 2 km far from the complex and can be reached in approximately 25 min on foot and in 15 min by public transport. Of the 12 bus lines covering the area, only 4 connect Torrevecchia with the city centre.
Torrevecchia district: overall analysis.
Data regarding facilities shows that compulsory schools are insufficient to serve the catchment area. Conversely, there are four technical/professional schools within a 2 km radius of the area under examination. The entire area suffers from a serious lack of facilities which is revealed by the presence of one pharmacy for every 24,500 inhabitants, as opposed to what is required by the Italian law L.362/91 (Art. 1), which is one every 12,500 inhabitants.
Torrevecchia still preserves evident signs of the past rural vocation. The valley between the IACP complex and the Quartaccio district is the least urbanized part of the neighborhood. Despite several green expanses, still not affected by irregular urbanization, the neighborhood is in fact devoid of proper public parks. The only two parks, the Insugherata Nature Reserve and the Pineto Urban Regional Park, are more than 2 km away from the centre of Torrevecchia. Out of more than 65 ha of green areas, only 3% are organized in equipped areas.
Air quality is significantly and positively affected by the abundance of proximity greenery (parks and reserves), although uncultivated and derelict. The average concentration of nitrogen dioxide NO2 is about 32.13 μg/m3, far lower than the annual limit value for human health protection, established by D.Lgs. 155/2010 which provides for a maximum limit of 40 μg/m3. As for fine particles, according to what is reported by a PM2.5 map obtained from a dispersion model, the average annual concentration is 18.31 μg/m3, which is far lower than the limit value of 25 μg/m3 (D. Lgs. 155/2010 in force since 2015).
As regards the microclimatic conditions (Figure 4), in the summer season, the area is affected by winds coming from south west (speed of 16 km/h) which considerably contribute to cooling the south-west area that is most of the time subject to direct radiation during the day, given the poor vegetation and the low building heights. The square to the north-east receives just as much radiation, but the layout of the surrounding buildings prevents it from adequate ventilation. In the winter season, the cold wind coming from north east (speed of 9 km/h) sharpens the perception of comfort in the north-east square, which remains cold and in the shade all day long taking into account average winter temperatures of about 7°C. Throughout the day, the south-west square catches the sunlight in its highest part since the shadows cast by the storey buildings are reduced compared to the width of the square.
Solar analysis: the tower building in Torrevecchia district.
The tower buildings, especially on the higher floors, enjoy summer ventilation from the south-west but suffer from winter ventilation on the north-east façades, which correspond exactly to the façades with a higher percentage of openings.
The tower buildings, 43.2 m high and with a floor area of approximately 4140 m2, house 76 accommodations (48 units of 60 m2 and 28 of 45 m2) for 248 estimated occupants. A comparison between current users and the availability of floor area, results in 16.7 m2 per person. According to the national legislation, the building should thus house no more than 207 inhabitants. The 60 m2 apartments feature a double exposure while the 45 m2 apartments have a single-exposure. The 60 m2 apartments are designed to accommodate 4 people but both bedrooms (12.4 m2 and 12.8 m2 big) are smaller than 14 m2, thus do not meet the current minimum standards. It is estimated that the prevalent (50%) family unit typology in Torrevecchia is composed of 1 or 2 members, while families with 4 members account for only 12% of all families.
Starting from the overall critical evaluation a project concerning both adjacent outdoor and indoor spaces has been developed with particular emphasis on bioclimatic solutions (Figure 5). In the first place, it is essential to redesign the building’s connection to the ground, its consequent relationship with the street as well as the intermediate in-between public spaces, to provide meeting and relational opportunities. A necessary prerequisite is an involvement of the inhabitants from the very start, ranging from the preliminary design to the future management and care of common spaces. To integrate the facility system, currently rather inadequate, and enhancing the relationship between building and streets, an elevated square is proposed. The new plaza consists of a solid volume with internal excavated patios and courtyards. Vocational training laboratories, also meant to work as local facilities are located on the ground floors of the towers and in the hypogeal areas beneath the elevated square. A system of ramps allows connecting the different levels on which the public outdoor spaces are distributed. Therefore, the square becomes an open space arranged on two levels on which some food services, laboratories and craft shops open. The internal patios enable to host in the hypogeal spaces several other facilities and services, providing them with adequate light and ventilation and with quality green outdoor space of relevance. The derelict south-west green square is transformed into plots of collective urban gardens managed and used by inhabitants.
Exploded axo: overall project and focus on bioclimatic solutions.
When it comes to the tower building, the redesign of the ground connection through an excavation on the short façades (north-west and south-west) strongly contributes to improving thermo-hygrometric and visual comfort parameters of the former basement which is thus freed on two sides from direct contact with the damp ground. The ground floor and the basement are merged to obtain double-height rooms suitable for hosting a kindergarten and fab-labs with an external space of relevance gained thanks to the excavation.
To maximize the feasibility of the project, the intention is to limit as much as possible the need for the inhabitants to temporarily leave their homes. Therefore, priority actions address the need to provide all accommodations with adequate living space in terms of square meters to satisfy standards imposed by national law. The addition of plug-and-play modules on the north-east and south-west façades, diversified on a technical level according to the exposure, can solve simultaneously problems related to poor lighting, poor insulation and consequent thermal comfort and under-sizing. The buffer-space modules added to the north-east façade and the bioclimatic greenhouses added to the south-west façade make up new indoor or outdoor living spaces, diversified internally about the type of environment to which they are added and to the needs of the occupants. It’s a system of prefabricated units, ranging from 2 to 8 m2 big, which add a total of about 10 m2 to each dwelling, which corresponds to 17% additional surface area in the case of the two-room apartment and 14.5% for the four-room apartment.
The bioclimatic greenhouses leaning on the south-east, south-west and south elevations constitute heat accumulation spaces to introduce preheated air into the apartments. The structure is made up of modular steel elements with transparent vertical closures in white solar glass, with a solar factor higher than 70% and with an openable glass surface of 65% out of the overall transparent closure. Sliding panels with adjustable slats in natural fibers and thermosetting resins work like shields. The modules jut out differently according to the functional and structural needs, ranging from 120 to 240 cm. The buffer-spaces, attached to the north-east elevation, highly contribute to improving the overall energy performance, through the reduction of heat loss and consequent thermal gains in winter and through the dissipation of heat in summer. The overhang is 90 cm and the structure is similar to that of the greenhouses but with low-emissivity glass and a solar factor lower than 35%.
New dwellings can be added on the roof, taking advantage of the incentive offered by the regional law L.R. 7/2017 on urban regeneration which allows adding 20% of the original building volume or the original floor surface in case of energy efficiency interventions on residential buildings. The new volumes have a dry load-bearing structure in X-Lam panels and are placed on a load-bearing structure in IPE steel beams to detach and slightly lift the housing module from the existing roof and thus ensure natural ventilation. Each dwelling is equipped with photovoltaic panels (20.50 m2) and solar collectors integrated into the roof to assure self-sufficiency in terms of energy.
The original flat roof is replaced with an extensive green roof covered by a pitched canopy which, besides ensuring shading, is also designed to collect rainwater through the central impluvium for irrigating the green roof. The green-blue roof combines different technologies allowing an increase in the storing capacity and a control system of the water flow to release. The green roof helps to cool and humidify the surrounding air, positively affecting the microclimate with slight effects also for the squares located at the street level. In doing so, the storey just beneath the roof slab gains in thermal insulation, therefore less indoor overheating results in less consumption for air conditioning, affecting the overall energy balance. In addition, the vegetated surface effectively protects the waterproofing membrane from UV rays, hail, heat and cold, contributing in the long term to the building envelope maintenance. At the same time, the roof becomes a common space available for all the building users.
Where plug-and-play modules are not applied, an 8 cm sheep wool insulation is laid on the external current envelope to achieve a new transmittance of 0.33 W/m2 K to ensure an overall optimization of the building energy performance.
San Basilio (Figure 6) is located in the IV municipality, in the north east of Rome, in the urban area 5E, and borders the Grande Raccordo Anulare, an orbital motorway that encircles Rome, to the east and Casal de’ Pazzi and Tor Cervara to the west. The municipality is delimited by the via Nomentana to the north, by the municipality of Guidonia Montecelio to the east, by via Tiburtina, the Aniene river, the A24 motorway and the Rome-Pescara railway to the south, and the Rome-Florence railway to the west.
Aerial view of San Basilio district (source: Google Earth).
Between 1981 and 1988, the
According to the 2011 ISTAT census, it is clear that about 27% of the district inhabitants are between 45 and 60 years old and over half of the families are composed of a single member, 27% of 2 members and only the remaining 20% are families of 3, 4 or 5 components. One-third of the inhabitants have not more than a middle school diploma and only 10% have a university degree, half of the figure for graduates in Rome (20%). The number of unemployed is about 2% higher than the Roman average and about half of the population lives in rented apartments. The neighborhood is also known for the strong presence of petty crime and drug dealing.
Different multi-thematic analyses were carried out concerning mobility, facilities and green systems (Figure 7). The mobility analysis highlights how the area under examination is a sort of enclave to the district that stretches to the west, as it is connected to the urban fabric of the old San Basilio district and the rest of the city only by two access roads. The closest metro station is almost 3 km away. A station was supposed to be built in the old San Basilio area but the project for the extension of the metro Line B has never been realized. As for local public transport, although the area is served by several bus lines, these are not sufficient to ensure a direct and rapid connection with the city centre.
San Basilio district: overall analysis.
With regard to the facilities, since there are no public or private ones within a radius of 250 m from the area under examination, and only a mechanic within a radius of 500 m, one is forced to travel almost 1 km to reach a supermarket, pharmacy or the nearest primary school. 57% of the district facilities are ascribable to retail trade, while public space meant for squares does not exceed 2%.
The several parks and green spaces in the area are unequipped and poorly maintained. In general, the outdoor spaces lack even the most basic elements of street furniture. This leads inhabitants to use these spaces only to go from one place to another and not for social purposes. Moreover, inadequate public lighting increases the feeling of insecurity among the inhabitants.
The microclimatic analysis (Figure 8) shows that the area under examination is affected by cold winter winds coming from east, north-east (about 9 km/h) and by hot summer winds coming mainly from south-west with a speed of approximately 16 km/h. In the summer season, both the north-east square and the southern square adjacent to the building suffer significant overheating phenomena throughout the whole day, yet moderated by ventilation. In winter, the northern square lays most of the time in the shade and is constantly exposed to cold winter winds due to the absence of adjacent buildings.
Solar analysis on the linear building in San Basilio district.
The building under consideration (6G) is a linear multistorey building typology of about 42 × 13 m consisting of 7 floors above ground and a basement floor. The building currently houses about 135 people for a total of 45 apartments of 50, 60, 80 and 100 m2, accounting respectively for 40%, 30%, 25% and 5% of the total housing units. The structure is in reinforced concrete bearing walls that define a succession of different sized spans parallel to the short side. The façade is characterized by prefabricated concrete blocks with a minimum insulating layer of glass wool. The joints have not been carefully designed and the discontinuity of the insulating layer causes several thermal bridges. The building is equipped with two staircases and the access is via a gallery located on the ground floor at a height of +1.00 m, above the cellar floor, accessible from the condominium staircases. Currently, the ground floor houses, in the eastern part, two special housing units for people with physical disabilities and two rooms initially designed to be a condominium space and a laundry for common use. At the moment, the western part is occupied by storage spaces but it was meant to be—according to the original project—a
The analysis of the current condition reveals the need to rethink the building in all its aspects (Figure 9) starting from its connection to the ground not only in terms of spaces and functions but also about the square in front. The special apartments on the ground floor are to be relocated, in terms of living space, on the roof level and the currently unused common spaces are to be converted into local and building facilities chosen according to what emerged from the previous social analysis. In rethinking the relationship with the outdoor spaces, the current gallery at a height of +1.00 m is redesigned in terms of accessibility, use and relationship with the square, providing for its expansion in some points to create terraces to serve the new activities and rest areas to encourage meeting and socialization occasions. A co-working, refreshment and internet point could be located in the western part of the ground floor (internal height of 3.70 m) at the same level as the square and near the main road. These spaces are thought of as facilities for the entire local community. The remaining part of the same floor (with an internal height of 2.70 m) could host a series of flexible spaces, including a medical-assistance clinic with an adjoining small outpatient clinic where professionals can offer different services on shifts, multi-purpose spaces for courses and activities and a bicycle repair workshop.
Exploded axo: overall project and focus on bioclimatic solutions.
Overall, the existing envelope does not meet current national standards for energy performance for buildings. In this regard, a new insulation layer must replace the previous thin and inadequate one together with the application of a ventilated façade in specific parts. Old windows are replaced by new ones in recycled aluminum with thermal break and double glazing with argon gas inside, with a global transmittance of 1.56 W/m2 K compared to the maximum 1.80 W/m2 K required by law.
The current design of the housing units of the standard storey does not make the most out of the living space. A new distribution of indoor spaces in favor of living areas located south and an implementation of new spaces to increase liveability, are required. In this regard, steel plug-and-play modules added to the façade, besides providing additional volume, can also be configured as bioclimatic devices by hosting greenhouses or buffer spaces depending on the orientation or, in some cases, as balconies or galleries. To make the housing units more compliant with the family units—according to socio-demographic data—one standard storey could be turned into a cohousing for about 40 members. This housing typology, mainly designed for relatively young users, single or couples, spreads over one entire floor and is accessible from both staircases. The sleeping area is essentially located in the east and west wings and the north. The south front instead hosts several shared spaces in sequence, such as a kitchen equipped with a dining area, a common living room, a mini cinema/games room and a common laundry room, all joined by a single glazed connection placed in adherence to the south façade. To ensure adequate ventilation inside the single-exposure apartments (about 60% of the total), a geothermal cooling/heating system operated by wind towers is inserted. In the light of the microclimatic analysis, the tower collection heads should be placed where airspeed accelerations occur both in summer and in winter. The air is trapped and then directed through underground ducts—where thanks to geothermal energy it is pre-heated/cooled depending on the season—to the apartments to be, in a second step, introduced into each room through a distribution system installed in the false ceilings positioned over the service and distribution spaces.
With regards to the roof, the availability of such a large free surface allows the implementation of different passive and active strategies as well as technological devices. Special housing units (once located on the ground floor) and common spaces are relocated on the roof. These new accommodations, larger and suitable for families of 4–5 members, have been designed for a different target audience, to encourage different people to approach the neighborhood and thus promote social
Moreover, a common laundry room, a greenhouse for food production and a common outdoor kitchen/dining area are integrated as new volumes on the roof. The roof is also equipped with a system for the collection and reuse of rainwater and gray water. The uncovered surfaces are redesigned to better capture rainwater and convey it to specific collection points. From here, the water is filtered and purified and then used for cleaning and irrigation purposes for outdoor spaces, toilet drains and washing machines. With regard to gray water—before being stored in the collection point—it undergoes a different purification process and is later reinserted into the general circuit. This system can bring about significant clear water savings accounting for about 20%. The building is also equipped with a photovoltaic system for electricity production. The system is composed of polycrystalline modules of the size of 50 × 50 cm with a nominal power of 35-W peak each. The energy produced, equal to about 17,000 kWh per year, will feed, not only the lighting system—replaced with LED elements—but also the heat pumps for the underfloor heating system and part of the domestic consumption. A small portion of the roof is also meant for a solar thermal system for domestic hot water production, consisting of 18 panels of about 2 m2, for a total of 36 m2, able to cover 50% of the annual housing needs.
Currently, most of the interventions on ERP have an emergency nature: direct operations aimed at solving specific problems in the short term. This logic, devoid of investment, does not allow to respond to broader issues, without halting the heritage deterioration. Today it is even more necessary to outline intervention strategies capable of coping with the technical-functional aging of buildings. The ERP heritage of the city of Rome can become the key element for a qualitative regeneration of the city. According to socio-demographic data, it is possible to point out similar contexts, characterized by strong social unrest, petty crime and a high unemployment rate (23% in Torrevecchia and 16% in San Basilio). About the district population, that of San Basilio is generally younger and made up of larger families compared to that of Torrevecchia. Yet, in both cases, the most recurrent family unit is composed of 1 or 2 members. Not only the different characteristics of the plano-volumetric system but also those related to the socio-economic, environmental and microclimatic context play their part in the choice of which strategies and solutions implemented.
The study carried out allowed to investigate and compare the limits and the potentialities deriving from the building typology and its plano-volumetric system:
Ground floor. As a direct consequence of the building typology, the linear multistorey building undoubtedly presents a greater availability of space in terms of surface area. This feature allows the introduction of several different facilities on the ground floor, by simply replacing the existing housing units, poorly lit and ventilated and with serious privacy concerns. The new facilities are chosen according to the socio-demographic analysis output and the structural-dimensional characters of the building and address different target users at different scales (inhabitants of the building, of the neighborhood, of the district). In addition, the larger perimeter of the ground floor in this building typology allows greater freedom in rethinking the relationship with the relevant outdoor spaces, enhancing the integration between facilities and pertinent outdoor spaces. In the tower building typology, given the limited availability of surface, the possibility of integrating different facilities is consequently quite limited. The reduced ground floor surface area requires to use of additional storeys to host facilities running into the limits resulting from the reduced internal heights of the upper floors (originally intended for housing). About the useful heights, in the specific case of San Basilio, two public exercises with a district-scale catchment area can be introduced in the area with a useful height of 3.70 m. In the case of Torrevecchia, to overcome these design limitations, the creation of a new elevated public square, in-between the tower buildings, revealed to be the best solution for hosting laboratories for professional training, retail shops and craft labs whilst guaranteeing quality outdoor space at the same time.
Standard floor. The linear multistorey building, as opposed to the tower typology, tends to house a greater number of single-exposure apartments, which consequently face serious problems related to indoor ventilation. This aspect is mainly linked to the need for a greater surface area for connection purposes to serve all the apartments. Unlike linear typologies, in tower buildings, the connective surface is reduced to the least and corresponds to the stair and elevator block. On the other hand, the linear typology allows greater freedom in redefining the standard floor plan by changing the dimensions of the existing housing units to adapt them to the user’s needs. About the apartments, in Torrevecchia their dimensions were deemed suitable for the users and more than two-thirds of them have double exposure. In the case of San Basilio, this proportion is roughly the opposite, with % single exposure apartments accounting for 60%. As mentioned above the single exposure led to the introduction of wind towers to improve ventilation in indoor environments. Some of the apartment rooms in Torrevecchia, such as the double bedrooms, do not meet the minimum standards required by law. Therefore, the addition of new plug-and-play modules on the façades allows for to increase in the limited current surface area and meets the standards.
Roofing. Taking into consideration the linear typology, likewise the ground floor, the roof level has a greater surface. It offers, in the first place, the chance to implement several technological, active and ecological devices, to gain significant overall energy-water savings:
A photovoltaic system for electricity production: the larger roof surface allows to install a more powerful photovoltaic systems capable of satisfying a higher share of electricity consumption. In the linear typology, the cost is maximized, since it does not require any integrated systems on the façade, and since the system is more efficient thanks to the possibility of positioning the panels according to the best exposure.
Rainwater collection system: the larger collecting surface allows to accumulate a greater quantity of water, achieving far higher water-saving percentages.
Furthermore, greater space availability also results in the possibility of adding new accommodations and several common spaces such as a laundry room, multi-purpose rooms and a common kitchen in order to provide the inhabitants new spaces in which to spend time and do activities together.
Although, the building typology is quite significant in defining the different possible intervention strategies, these must necessarily be contextualized according to the specific study/project area and its
The authors declare no conflict of interest.
General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed.
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\n\nRead more about Open Access in Horizon 2020 here.
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Intermetallic compounds are usually formed when alloying elements, such as Fe, Cu, Mn, Mg and Sr. are added to Al-Si based alloys. These elements are depicted by X in the alloys formation expression. The chapter noted that the most common intermetallics are iron (Fe) based, and several of these Fe-phases, including the most harmful Fe-phase, β-Al5SiFe, are listed and discussed. Fe-phase intermetallics are deleterious to the mechanical properties of Al-alloys; however, addition of <0.7% Fe helps prevent soldering in die casting mould. The effects of Fe-phase and other intermetallics formed by Cu, Mg and Mn were examined. Further, some techniques of eliminating or mitigating the negative influences of intermetallics were discussed.",book:{id:"6134",slug:"intermetallic-compounds-formation-and-applications",title:"Intermetallic Compounds",fullTitle:"Intermetallic Compounds - Formation and Applications"},signatures:"Williams S. Ebhota and Tien-Chien Jen",authors:[{id:"206268",title:"Dr.",name:"Williams",middleName:"S.",surname:"Ebhota",slug:"williams-ebhota",fullName:"Williams Ebhota"},{id:"214786",title:"Prof.",name:"Tien-Chien",middleName:null,surname:"Jen",slug:"tien-chien-jen",fullName:"Tien-Chien Jen"}]},{id:"54395",doi:"10.5772/67514",title:"Fundamentals of Chemical Vapor Deposited Graphene and Emerging Applications",slug:"fundamentals-of-chemical-vapor-deposited-graphene-and-emerging-applications",totalDownloads:3548,totalCrossrefCites:5,totalDimensionsCites:14,abstract:"Graphene, the atomically thin sheet of sp2 hybridized carbon atoms arranged in honeycomb structure, is becoming the forefront of material research. The chemical vapor deposition (CVD) process has been explored significantly to synthesis large size single crystals and uniform films of monolayer and bilayer graphene. In this prospect, the nucleation and growth mechanism of graphene on a catalytic substrate play the fundamental role on the control growth of layers and large domain. The transition metals and their alloys have been recognized as the active catalyst for growth of monolayer and bilayer graphene, where the surface composition of such catalysts also plays critical role on graphene growth. CVD-synthesized graphene has been integrated with bulk semiconductors such as Si and GaN for the fabrication of solar cells, photodetectors, and light-emitting diodes. Furthermore, CVD graphene has been integrated with hexagonal boron nitride (hBN) and transition metal dichalcogenides (TMDCs) for the fabrication of van der Waals heterostructure for nanoelectronic, optoelectronic, energy devices, and other emerging technologies. The fundamental of the graphene growth process by a CVD technique and various emerging applications in heterostructure devices is discussed in detail.",book:{id:"6215",slug:"graphene-materials-advanced-applications",title:"Graphene Materials",fullTitle:"Graphene Materials - Advanced Applications"},signatures:"Golap Kalita and Masaki Tanemura",authors:[{id:"17333",title:"Dr.",name:"Masaki",middleName:null,surname:"Tanemura",slug:"masaki-tanemura",fullName:"Masaki Tanemura"},{id:"195869",title:"Dr.",name:"Golap",middleName:null,surname:"Kalita",slug:"golap-kalita",fullName:"Golap Kalita"}]},{id:"39648",doi:"10.5772/51514",title:"Fundamental Aspects of Silicon Carbide Oxidation",slug:"fundamental-aspects-of-silicon-carbide-oxidation",totalDownloads:4371,totalCrossrefCites:6,totalDimensionsCites:13,abstract:null,book:{id:"3129",slug:"physics-and-technology-of-silicon-carbide-devices",title:"Physics and Technology of Silicon Carbide Devices",fullTitle:"Physics and Technology of Silicon Carbide Devices"},signatures:"Heiji Watanabe and Takuji Hosoi",authors:[{id:"153696",title:"Prof.",name:"Heiji",middleName:null,surname:"Watanabe",slug:"heiji-watanabe",fullName:"Heiji Watanabe"}]},{id:"37701",doi:"10.5772/50748",title:"Thermal Oxidation Mechanism of Silicon Carbide",slug:"thermal-oxidation-mechanism-of-silicon-carbide",totalDownloads:3525,totalCrossrefCites:6,totalDimensionsCites:11,abstract:null,book:{id:"3129",slug:"physics-and-technology-of-silicon-carbide-devices",title:"Physics and Technology of Silicon Carbide Devices",fullTitle:"Physics and Technology of Silicon Carbide Devices"},signatures:"Yasuto Hijikata, Shuhei Yagi, Hiroyuki Yaguchi and Sadafumi Yoshida",authors:[{id:"18137",title:"Dr.",name:"Yasuto",middleName:null,surname:"Hijikata",slug:"yasuto-hijikata",fullName:"Yasuto Hijikata"},{id:"18271",title:"Prof.",name:"Hiroyuki",middleName:null,surname:"Yaguchi",slug:"hiroyuki-yaguchi",fullName:"Hiroyuki Yaguchi"},{id:"18272",title:"Dr.",name:"Sadafumi",middleName:null,surname:"Yoshida",slug:"sadafumi-yoshida",fullName:"Sadafumi Yoshida"},{id:"152822",title:"Dr.",name:"Shuhei",middleName:null,surname:"Yagi",slug:"shuhei-yagi",fullName:"Shuhei Yagi"}]},{id:"60330",doi:"10.5772/intechopen.74176",title:"Preclinical Aspects on Magnetic Iron Oxide Nanoparticles and Their Interventions as Anticancer Agents: Enucleation, Apoptosis and Other Mechanism",slug:"preclinical-aspects-on-magnetic-iron-oxide-nanoparticles-and-their-interventions-as-anticancer-agent",totalDownloads:1325,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"The broad area of magnetic iron oxide nanoparticle (M-IONP) applications and their exclusive physico-chemical characteristics (superparamagnetic properties per se, solubility and stability in aqueous solutions, and high bioavailability in vivo) make these nanoparticles suitable candidates for biomedical uses. The most employed magnetic iron oxides in the biomedical field are magnetite and maghemite. Cancer represents a complex pathology that implies multiple mechanisms and signaling pathways, this complexity being responsible for the increased resistance to therapy and the lack of an effective curative treatment. A potential useful alternative was considered to be the use of magnetic iron nanoparticles. The M-IONPs proved to be effective as contrast agents in magnetic resonance imaging, as drug delivery carriers for different therapeutic agents, in magnetic cell separation assays, and are suitable to be engineered in terms of size, targeted delivery and substance release. Moreover, their in vivo administration was considered safe, and recent studies indicated their efficiency as anticancer agents. This chapter aims to furnish an overview regarding the physico-chemical properties of M-IONPs (mainly magnetite, maghemite and hematite), the synthesis methods and their in vitro biological impact on healthy and cancer cell lines, by describing their potential mechanism of action—enucleation, apoptosis or other mechanisms.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Elena-Alina Moacă, Elena Dorina Coricovac, Codruta Marinela\nSoica, Iulia Andreea Pinzaru, Cornelia Silvia Păcurariu and Cristina\nAdriana Dehelean",authors:[{id:"141027",title:"Dr.",name:"Cristina",middleName:null,surname:"Dehelean",slug:"cristina-dehelean",fullName:"Cristina Dehelean"},{id:"173283",title:"Dr.",name:"Dorina",middleName:null,surname:"Coricovac",slug:"dorina-coricovac",fullName:"Dorina Coricovac"},{id:"186678",title:"Dr.",name:"Codruta",middleName:null,surname:"Soica",slug:"codruta-soica",fullName:"Codruta Soica"},{id:"217849",title:"Associate Prof.",name:"Iulia Andreea",middleName:null,surname:"Pinzaru",slug:"iulia-andreea-pinzaru",fullName:"Iulia Andreea Pinzaru"},{id:"219727",title:"Mrs.",name:"Elena Alina",middleName:null,surname:"Moaca",slug:"elena-alina-moaca",fullName:"Elena Alina Moaca"},{id:"219728",title:"Prof.",name:"Cornelia Silvia",middleName:null,surname:"Pacurariu",slug:"cornelia-silvia-pacurariu",fullName:"Cornelia Silvia Pacurariu"}]}],mostDownloadedChaptersLast30Days:[{id:"58868",title:"Iron Ore Pelletizing Process: An Overview",slug:"iron-ore-pelletizing-process-an-overview",totalDownloads:4575,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"The iron ore production has significantly expanded in recent years, owing to increasing steel demands in developing countries. However, the content of iron in ore deposits has deteriorated and low-grade iron ore has been processed. The fines resulting from the concentration process must be agglomerated for use in iron and steelmaking. This chapter shows the status of the pelletizing process with a special focus on binders. Bentonite is the most used binder due to favorable mechanical and metallurgical pellet properties, but it contains impurities especially silica and alumina. The importance of many researches concerning alternative binders is also discussed in this chapter. Better quality wet, dry, preheated, and fired pellets can be produced with combined binders, such as organic and inorganic salts, when compared with bentonite-bonded pellets. While organic binders provide sufficient wet and dry pellet strengths, inorganic salts provide the required preheated and fired pellet strengths.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Sandra Lúcia de Moraes, José Renato Baptista de Lima and Tiago\nRamos Ribeiro",authors:[{id:"216788",title:"Dr.",name:"Sandra",middleName:"Lúcia",surname:"De Moraes",slug:"sandra-de-moraes",fullName:"Sandra De Moraes"},{id:"233466",title:"Prof.",name:"José Renato Baptista",middleName:null,surname:"De Lima",slug:"jose-renato-baptista-de-lima",fullName:"José Renato Baptista De Lima"},{id:"233467",title:"MSc.",name:"Tiago Ramos",middleName:null,surname:"Ribeiro",slug:"tiago-ramos-ribeiro",fullName:"Tiago Ramos Ribeiro"}]},{id:"58937",title:"Intermetallics Formation and Their Effect on Mechanical Properties of Al-Si-X Alloys",slug:"intermetallics-formation-and-their-effect-on-mechanical-properties-of-al-si-x-alloys",totalDownloads:1854,totalCrossrefCites:11,totalDimensionsCites:22,abstract:"This study focuses on primary impurities, called intermetallics, in the microstructure of Al-Si-X alloys, their formation, effects and treatments to eliminate or ameliorate their deleterious effects. Intermetallic compounds are usually formed when alloying elements, such as Fe, Cu, Mn, Mg and Sr. are added to Al-Si based alloys. These elements are depicted by X in the alloys formation expression. The chapter noted that the most common intermetallics are iron (Fe) based, and several of these Fe-phases, including the most harmful Fe-phase, β-Al5SiFe, are listed and discussed. Fe-phase intermetallics are deleterious to the mechanical properties of Al-alloys; however, addition of <0.7% Fe helps prevent soldering in die casting mould. The effects of Fe-phase and other intermetallics formed by Cu, Mg and Mn were examined. Further, some techniques of eliminating or mitigating the negative influences of intermetallics were discussed.",book:{id:"6134",slug:"intermetallic-compounds-formation-and-applications",title:"Intermetallic Compounds",fullTitle:"Intermetallic Compounds - Formation and Applications"},signatures:"Williams S. Ebhota and Tien-Chien Jen",authors:[{id:"206268",title:"Dr.",name:"Williams",middleName:"S.",surname:"Ebhota",slug:"williams-ebhota",fullName:"Williams Ebhota"},{id:"214786",title:"Prof.",name:"Tien-Chien",middleName:null,surname:"Jen",slug:"tien-chien-jen",fullName:"Tien-Chien Jen"}]},{id:"54372",title:"Photoinduced Pseudospin Dynamical Effects in Graphene-Like Systems",slug:"photoinduced-pseudospin-dynamical-effects-in-graphene-like-systems",totalDownloads:1644,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"In this chapter, we describe some of our recent results on the laser-induced manipulation of the energy band structure of graphene-like systems. We present numerical results on the quasi-energy spectrum as well as detailed calculations of semi-analytical approximations to other physical quantities of interest. The main message we would like to convey to the interested reader of the chapter is that by properly tuning the perturbation parameters of the radiation field one can control the size and shape of the photoinduced gaps. These in turn would allow the realization of new electronic phases on graphene and its related materials such as silicene.",book:{id:"5722",slug:"graphene-materials-structure-properties-and-modifications",title:"Graphene Materials",fullTitle:"Graphene Materials - Structure, Properties and Modifications"},signatures:"Alexander López and Benjamin Santos",authors:[{id:"195536",title:"Dr.",name:"Alexander",middleName:null,surname:"López",slug:"alexander-lopez",fullName:"Alexander López"},{id:"204551",title:"MSc.",name:"Benjamin",middleName:null,surname:"Santos",slug:"benjamin-santos",fullName:"Benjamin Santos"}]},{id:"58482",title:"Calcination and Pelletizing of Siderite Ore",slug:"calcination-and-pelletizing-of-siderite-ore",totalDownloads:1279,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In the present study, calcination properties of Hekimhan-Deveci siderite (FeCO3) ore and the effect of calcination process before the pelletization on strength of pellet were investigated and evaluated. Two different calcination processes were followed. One of them is the traditional calcination process and the other one is microwave assisted calcination process which is a new process for siderite ore. The characterization of the calcined and uncalcined siderite ore was done using X-ray diffraction, X-ray fluorescence spectrometry and thermogravimetric analysis. The physical and mechanical properties of pellets which were obtained using the raw siderite and the calcined siderite were compared with each other. As a result of experimental studies, it was found that the calcination process decreased the milling time, causing the significant energy saving and the most suitable calcination process for siderite ore was found as 15 min at 700°C temperature. It was the first time that the calcination process of the siderite ore was achieved by microwave by adding 30 wt% sucrose as a thermal auxiliary. The microwave conditions were determined as 900 W at 3 min. In 3 min, the temperature of the siderite ore increased up to 1100°C and 32.14% weight loss for the sample was achieved.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Mehmet Celikdemir, Musa Sarikaya, Tolga Depci, Ramazan\nAydogmus and Aysegul Yucel",authors:[{id:"212301",title:"M.Sc.",name:"Mehmet",middleName:null,surname:"Çelikdemir",slug:"mehmet-celikdemir",fullName:"Mehmet Çelikdemir"},{id:"213405",title:"Prof.",name:"Musa",middleName:null,surname:"Sarikaya",slug:"musa-sarikaya",fullName:"Musa Sarikaya"},{id:"213412",title:"Prof.",name:"Tolga",middleName:null,surname:"Depci",slug:"tolga-depci",fullName:"Tolga Depci"},{id:"213413",title:"MSc.",name:"Ramazan",middleName:null,surname:"Aydoğmuş",slug:"ramazan-aydogmus",fullName:"Ramazan Aydoğmuş"},{id:"227119",title:"MSc.",name:"Ayşegül",middleName:null,surname:"Yücel",slug:"aysegul-yucel",fullName:"Ayşegül Yücel"}]},{id:"69224",title:"Introductory Chapter: Cobalt Compounds and Applications",slug:"introductory-chapter-cobalt-compounds-and-applications",totalDownloads:761,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"8886",slug:"cobalt-compounds-and-applications",title:"Cobalt Compounds and Applications",fullTitle:"Cobalt Compounds and Applications"},signatures:"Aynur Manzak and Yasemin Yildiz",authors:[{id:"208129",title:"Dr.",name:"Yasemin",middleName:null,surname:"Yıldız",slug:"yasemin-yildiz",fullName:"Yasemin Yıldız"}]}],onlineFirstChaptersFilter:{topicId:"950",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"87",type:"subseries",title:"Economics",keywords:"Globalization, Economic integration, Growth and development, International trade, Environmental development, Developed countries, Developing countries, Technical innovation, Knowledge management, Political economy analysis, Banking and financial markets",scope:"\r\n\tThe topic on Economics is designed to disseminate knowledge around broad global economic issues. Original submissions will be accepted in English for applied and theoretical articles, case studies and reviews about the specific challenges and opportunities faced by the economies and markets around the world. The authors are encouraged to apply rigorous economic analysis with significant policy implications for developed and developing countries. Examples of subjects of interest will include, but are not limited to globalization, economic integration, growth and development, international trade, environmental development, country specific comparative analysis, technical innovation and knowledge management, political economy analysis, and banking and financial markets.
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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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