Localization and putative function of TRPV1 channels
\r\n\tThe present book intends to provide to the reader a comprehensive overview of the state of art in empathy studies, embracing the different theoretical points of view and illustrating the advanced research such as the application of new technologies to promote perspective-taking. The critical aspects and the future directions of the study on empathy will also be presented.
",isbn:"978-1-80356-612-2",printIsbn:"978-1-80356-611-5",pdfIsbn:"978-1-80356-613-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"4c1042dfe15aa9cea6019524c4cbff38",bookSignature:"Ph.D. Sara Ventura",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11443.jpg",keywords:"Theoretical Model, Skill, Perspective Taking, Training Programs, Practical Implications, Advanced Research, Future Directions, Virtual Reality, Augmented Reality, New Trends, Assistive Technology",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 1st 2022",dateEndSecondStepPublish:"June 8th 2022",dateEndThirdStepPublish:"August 7th 2022",dateEndFourthStepPublish:"October 26th 2022",dateEndFifthStepPublish:"December 25th 2022",remainingDaysToSecondStep:"21 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Passionate researcher in the application of new technologies to psychological treatments, neuro-rehabilitation, human behavior, and the evolution of the human-computer interaction. In 2017 Dr. Ventura won a competitive grant (Santiago Grisolia) at the University of Valencia at LABPSITEC group, where she was awarded her Ph.D. degree, supervised by Prof. Rosa Baños at the University of Valencia, and co-directed by Prof. Giuseppe Riva of the Catholic University of Milan.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"227763",title:"Ph.D.",name:"Sara",middleName:null,surname:"Ventura",slug:"sara-ventura",fullName:"Sara Ventura",profilePictureURL:"https://mts.intechopen.com/storage/users/227763/images/system/227763.jpg",biography:"Sara Ventura gained a B.Sc in Psychology at the University of Padua (Italy) in 2013 and an M.Sc. in Ergonomic Psychology at the Catholic University of Milan (Italy) in 2015. In 2016, she carried out a postgraduate training at Universidad Nacional Autónoma de Mexico (Mexico) at the Ciberpsychology lab, working on a rehabilitation protocol for people with acquired brain injury through Virtual Reality. In 2020, Sara gained the Ph.D. in Clinical Psychology at University of Valencia (Spain) working with the LabPsitec group and focusing her research on the study of embodiment and empathy with the support of Virtual Reality. Actually, she is working both with Alma Mater Studiorum – University of Bologna (Italy), and the University of Valencia (Spain) on the fields of embodiment, stroke rehabilitation, empathy and patient care. Her research interests mainly focus on the adoption of new technologies, particularly Virtual/Augmented Reality and Artificial Intelligence for the psycho-social wellbeing with clinical and non-clinical populations, the study of human-computer interaction, and the user experience. She is the author of several scientific papers and various presentations at national and international conferences.",institutionString:"University of Valencia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Valencia",institutionURL:null,country:{name:"Spain"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"21",title:"Psychology",slug:"psychology"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"455410",firstName:"Dajana",lastName:"Jusic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/455410/images/20500_n.jpeg",email:"dajana.j@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"46317",title:"TRP Channels in Neuronal and Glial Signal Transduction",doi:"10.5772/58232",slug:"trp-channels-in-neuronal-and-glial-signal-transduction",body:'Many physiological processes like muscle contraction, hormone secretion and intracellular signalling processes are triggered by calcium as intracellular signalling molecule. The signal transduction capacity of calcium depends on the 10,000-fold gradient across the plasma membrane with 2.5 mM extracellular and resting intracellular calcium ion concentration of approximately 100 nM. Low intracellular calcium concentrations are managed by the extrusion of calcium by ATPases and transporters [1, 2], whereas rapid and distinct increases in intracellular calcium up to micromolar concentrations are mediated by calcium-permeable ion channels of the plasma membrane as well intracellular calcium storage compartments. Calcium mediates its biological functions by protein structures capable to bind calcium. These calcium-binding domains are building blocks of the proteins modulated by calcium directly or part of calcium sensor proteins (calmodulin, calcium binding protein, calcineurin, S100, NCS etc) mediating calcium-dependent modulation by protein-protein interaction [3].
In excitable cells like neurons, heart or skeletal or smooth muscle cells, calcium currents first identified are mediated by voltage-gated calcium channels [4-6]. Later, additional calcium-permeable ion channels have been identified mediating hormone-induced calcium entry also in non-excitable cells like endothelial, epithelial, immune cells. The identity of these channels has been unravelled via analysis of phototransduction in flies [7]. Montell and Rubin cloned Transient Receptor Potential (TRP) from
TRP channels have been identified and characterized by common biochemical, immunochemical and physiological methods. The function of TRP channels can be directly studied by patch clamp electrophysiology as well as imaging techniques. Patch clamp techniques enable to monitor currents across the plasma membrane mediated by TRP channels using small electrodes in small pipettes together with the ground electrode in the bath solution [20]. In this configuration, the electrical activity of ion channels in the plasma membrane can be monitored. Depending on configuration and access of the electrode within the patch pipette, different configurations can be discriminated (cell-attached, whole cell, inside-out or outside-out). On the other hand, a growing number of methods has been developed to monitor changes in ion concentrations in intact cells using small chemical compounds or artificial proteins constructs [21]. Fura-2 is one of the best known calcium dyes, a small chemical compound changing its fluorescence features depending on calcium concentration [22]. In the meantime a variety of new compounds have been developed characterized by changed ion selectivity, changes in Kd values or fluorescence intensities. The intracellular concentration of the indicator dyes depend on the activity and capability of organic solute carrier to export the dyes and thereby lowering intracellular dye concentrations. This disadvantage can be overcome by the use of the new protein-based probes. These artificial proteins are constructs of ion binding domains conjugated with fluorescence protein domains transcribed transiently from transfected plasmids or permanently from genomic localized expression cassettes [23, 24].
The following review will give an introduction in the broad field of TRP channel research related to their expression in the central nervous system (CNS), their physiological function in neurons as well as in glia cells, and their role in neurological and psychiatric CNS disorders. The involvement of TRP channels in the pathophysiology of glioma and the sensing of pain is not discussed here [for comprehensive reviews please refer to [25, 26]].
The classic TRP channel family comprises seven different genes with proteins showing the highest sequence similarity to the prototypic
In the brain, TRPC1 expression was confirmed using a set of techniques ranging from RT-PCR, western blotting to confocal and electron microscopy. TRPC1 was detected in different brain regions of adult mice including the cerebellum, the hippocampus, the basal ganglia, the amygdala and the forebrain [29-31]. Strübing et al. showed that TRPC1 and TRPC5 channels are expressed in similar brain areas suggesting that they might form heteromers for example in the hippocampus [31]. However, empirical evidence for the existence of these heteromers is still lacking [32]. Only little is known about the distribution of TRPC channels in neurons. TRPC5 channels were suggested to be expressed mainly in distal dendrites and dendritic spines in lateral septal neurons. However, the expression pattern might differ in different brain areas and neurons [33]. Interestingly, TRPC1 protein was not only detected in neurons such as in the hippocampal CA1 or CA3 pyramidal cells [31], but also in astrocytes and oligodendrocyte progenitor cells [34-36]. Furthermore, mRNA for all TRPC channels including TRPC1 was found in the cortex of the mouse developing brain [37]. TRPC1, together with TRPC3 and TRPC5 were the main isoforms detected in this study. This expression pattern might be time dependent and species specific because TRPC4 and TRPC5 were the most prominent isoforms in the adult rat prefrontal cortex [38], whereas TRPC3 and TRPC6 channels are major TRPC mRNAs detected in adult mice [29]. TRPC2 being expressed in the rodent vomeronasal organ is clearly an exception [39]. In humans, TRPC2 is a pseudogene; the transcribed mRNA is functionless due to various stop codons [40]. In rodents, the transcription of the TRPC2 gene results in a functionally active protein involved in sensory responses to pheromones [39]. Genetic inactivation of TRPC2 in mice leads to loss of sex discrimination of male mice [41-43]. TRPC4 mRNA expression was observed in the adult mouse brain in the cortex, the hippocampus, the thalamus, the amygdala, the basal ganglia as well as the prefrontal cortex [29, 30, 38, 44]. TRPC4 protein expression was shown in the hippocampus, the cortex as well as the cerebellum [38, 44]. Using in situ hybridisation or immunocytochemistry, the expression of TRPC4 channels in different brain areas was specified. For example, TRPC4 was detected in cell layers of the prefrontal cortex [38] or in pyramidal CA1 and CA3 neurons of the hippocampus. In lateral septal neurons, TRPC4 channels were found on the cell surface of the soma and primary dendrites [33].
TRPC3 and TRPC6 mRNAs were demonstrated in the basal ganglia, the cerebellum, hippocampus as well as the forebrain [29]. TRPC3 protein expression in the brain especially in the prefrontal cortex and cerebellum was not only shown in rat and mouse tissues but also in human tissue obtained from subjects of different age groups [45]. TRPC3 channel expression was higher in the developing cortex compared to the adult cortex, whereas TRPC3 cerebral expression was not age-dependent. The protein expression of TRPC6 channels in the hippocampus is controversial. While several groups using pharmacological approaches or RT-PCR or western blot analyses describe TRPC6 channels being expressed in all hippocampal regions [46-51], Nagy and co-workers as well as Chung and colleagues show expression of TRPC6 channels selectively in the dentate gyrus and interneurons [52, 53]. Interestingly, in contrast to Tai et al. 2008, who described TRPC6 expression in hippocampal CA1 soma as well as in dendrites, Nagy’s data suggest that TRPC6 channels are mainly expressed in dendrites of interneurons and neurons from the dentate gyrus [49, 53]. In the developing brain TRPC6 channels protein expression peaked between postnatal day 7 and 14, a period known to be important for maximal dendritic growth [49]. For TRPC7, only low mRNA expression levels were published [29, 30]. TRPC3 channels are also expressed in astrocytes [54].
Melastatin, the founding member of the melastatin-like TRP family, was identified within a screen for proteins differentially regulated in melanocytes and melanoma cells [55]. Analysis of clinical data showed that the presence of melastatin expression in melanoma patients inversely correlates with the severity and survival [56-58]. Although melastatin is the first member of the TRPM family its activation mechanism and physiological role is still unclear. In line with the first description as protein involved in melanocyte physiology several reports confirmed this view. A completely unexpected function, the integration in retinal signal processing, has recently been discovered by the identification of TRPM1 expression in retinal ON bipolar cells [59]. The critical role of TRPM1 in mammalian phototransduction is also highlighted by several reports describing TRPM1 mutations in patients suffering from congenital stationary night blindness [60-63]. Only very little is known about TRPM1 function and expression in the CNS. Rather low mRNA TRPM1 expression was found in three studies in the brain [29, 64, 65].
From sequence similarity, TRPM3 is phylogenetically the closest neighbour to melastatin. TRPM3 is a polymodal ion channel activated by a variety of different stimuli like hypotonicity [66], sphingolipids [67], steroids [68, 69], nifedipine [69], and heat [70]. TRPM3 is activated by hypotonic extracellular solution and represents together with TRPV4, the volume-regulated TRP channels in the kidney [71, 72]. With the help of pharmacological tools, calcium entry induced by the application of hypotonic extracellular solutions can be assigned to TRPV4 and TRPM3 [71, 73-75]. While TRPV4 is activated by 4α-Isomers of phorbolesters and is blocked by ruthenium red, TRPM3 is activated by sphingosine and by pregnenolone-sulphate and blocked by gadolinium ions. TRPM3 is expressed in different areas of the CNS such as the hippocampus, the corpus callosum, the cortex or the hippocampus. These findings were reproduced in different studies using RT-PCR [29], northern blot [66, 76], as well as immunohistochemistry [77, 78]. TRPM3 channels are found in neurons (cerebral Purkinje neurons) as well as in oligodendrocytes [76-78]. Interestingly, neuronal expression of TRPM3 is present throughout development. However, it is almost lost in the adult brain [77]. In contrast, TRPM3 is highly expressed in oligodendrocytes in the adult brain.
The phylogenetically next neighbours to TRPM1 and TRPM3 are TRPM6 and TRPM7 [79]. The latter ones are involved in the body magnesium homeostasis [80]. While TRPM7 is ubiquitously expressed, TRPM6 is expressed in epithelial cells of the gut and the kidney and responsible for magnesium absorption and reabsorption. Loss-of-function mutations in TRPM6 are linked to autosomal-recessive hypomagnesemia with secondary hypocalcemia [81, 82]. TRPM6, TRPM7 and TRPM2 share a common structural feature. All three genes code for chimeric proteins combining a hexahelical transmembrane channel forming domain with a C-terminal enzymatic active domain [83]. In the case of TRPM6 and TRPM7, the pore-forming domains are fused to atypical alpha kinase-like structures. The functional role for the enzymatic domain is still under dispute. TRPM6 and TRPM7 are permeable for magnesium and for other essential divalent cations like Ca2+, Zn2+, Mn2+, Co2+ as well as toxic cations like Ba2+, Sr2+, Ni2+, Cd2+ [84, 85]. While TRPM6 mRNA was detected at low level in different brain areas [29], nothing is known about its role in the CNS. In contrast to TRPM6 channels, TRPM7 mRNA is highly expressed in the brain [29, 86]. In primary hippocampal neurons as well as in pyramidal hippocampal CA1 neurons in rat brain slices, TRPM7 was detected by different groups using immunocyto- and immunohistochemistry [87-89].
While divalent ions are the preferentially carried ion of TRPM6- and TRPM7-mediated currents, TRPM4 and TRPM5 form ion pores impermeable for divalent ions and allow selectively sodium to pass [90]. As sodium channels, TRPM4 and TRPM5 are paradoxically activated by increased intracellular calcium concentrations and represent calcium-activated sodium channels. TRPM4 is expressed in different brain regions including the thalamus, the hypothalamus, the medulla oblongata, the hippocampus and the spinal cord in mouse, rat as well as human brain (Lein et al., 2007; [29, 91]. In contrast to TRPM4, the expression of TRPM5 is restricted to a few cell types. TRPM5 is expressed in taste buds of the tongue and involved in the sensation of bitter and sweet taste [92, 93].
The remaining two TRPM channels proteins, TRPM2 and TRPM8, can also be discussed in the light of sensory functions. As already mentioned, TRPM2 represents a chimeric protein integrating an ADP-ribose hydrolase domain C-terminal to the pore-forming transmembrane domains [83]. Simultaneously to the ADP-ribose hydrolysing activity of the C-terminal enzymatic domain, TRPM2 is activated by ADP-ribose and it has been shown that the C-terminal part is essential for the function of the pore forming channel protein [94, 95]. Increased intracellular ADP-ribose concentrations are linked to genotoxic and/or oxidative stress of cells leading to the activation of the poly(ADP-ribose) polymerase (PARP) modulating protein stability by the mono and poly ADP-ribosylation of proteins [96]. This process of protein stability regulation is additionally controlled by an enzyme called poly(ADP-ribose) glucohydrolase (PARG). PARG reduces the post-translational poly ADP-ribose modifications to mono ADP-ribosylation, thereby increasing the intracellular ADP-ribose concentration leading to the activation of TRPM2. In whole cell calcium imaging experiments, the extracellular application of hydrogen peroxide results in the activation of TRPM2 validating its function as redox sensor. TRPM2 channels are preferentially expressed in microglia cells, the host macrophages of the CNS [97, 98]. In addition, in several brain regions such as the hippocampus, the cortex and the substantia nigra TRPM2 channels were also detected in neurons using RT-PCR, western blotting as well as immunohistochemistry [99, 100]. It was suggested that TRPM2 and TRPM7 channels form heteromers because knock-down of TRPM7 with siRNA is accompanied by down-regulation of TRPM2 channels [101]. TRPM8, the cold sensor, is mainly expressed in sensory neurons. TRPM8 is activated at temperatures between 8 °C to 28 °C as well as the secondary plant compound menthol and synthetic cooling compounds. Together with TRPA1, TRPM8 represent the cold sensors in human. Noxious cold is mediated by TRPA1 [26, 102].
Vanilloid structures, derivates of vanillin comprising eugenol, zingerone and capsaicin, are found in many spice plants and known for their individual characteristic flavour. Beside the use as spice, vanilloid containing plant extracts are used as remedy in the various traditions of folk medicines. Therapeutic and experimental use of capsaicin in pain treatment inspired research resulting in the unravelling of the molecular target of capsaicin. The molecular target, an ion channel related to
The warm and heat sensors (TRPV1 to TRPV4) and the cold sensors (TRPM8 and TRPA1) represent the thermosensors of the human body and cover the complete temperature range necessary for human life. As warning sensors expressed in dorsal root ganglia, the thermo TRPs are also involved in sensation and modulation of pain and therefore interesting as molecular targets for new pain-treating drugs. Most studies dealing with the structural and functional properties of the TRPV channel family in the CNS are focused on TRPV1. However, TRPV2, TRPV3 and TRPV4 are also detected in the CNS. In contrast for TRPV5 and TRPV6, there is no evidence for their expression in the CNS.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
Hippocampus (interneurons, dentate gyrus) | \n\t\t\tinvolved in anxiety and fear | \n\t\t\t[132, 151] | \n\t\t
\n\t\t\t | involved in LTD | \n\t\t\t[152, 153] | \n\t\t
involved in LTP | \n\t\t\t[152] | \n\t\t|
involved in pathogenesis of epilepsy | \n\t\t\t[126, 127] | \n\t\t|
hypothalamus | \n\t\t\tcentral osmoregulation | \n\t\t\t[154, 155] | \n\t\t
\n\t\t\t | central regulation of temperature | \n\t\t\t[108] | \n\t\t
Locus coeruleus | \n\t\t\tpotentiation of glutamate, | \n\t\t\t\n\t\t |
\n\t\t\t | adrenaline or norepinephrine release | \n\t\t\t[151] | \n\t\t
Cortex | \n\t\t\tinvolved in cortical excitability | \n\t\t\t[156] | \n\t\t
\n\t\t\t | involved in pathogenesis of epilepsy | \n\t\t\t[126] | \n\t\t
Striatum | \n\t\t\tfacilitation of glutamatergic | \n\t\t\t[157] | \n\t\t
\n\t\t\t | postsynaptic neurotransmission | \n\t\t\t[158] | \n\t\t
glutamate release | \n\t\t\t[159] | \n\t\t
Localization and putative function of TRPV1 channels
TRPV1 expression in the CNS was investigated using a variety of methods ranging from pharmacological characterization and immunohistochemistry [105] to RT-PCR [106], western blotting to radio ligand binding [107]. Beside the great variety of methods and studies the expression of TRPV1 in the brain remains controversial. Several studies showed a wide spread TRPV1 expression in the CNS suggesting an expression of TRPV1 in pyramidal neurons of the CA1, CA3 area of the hippocampus, the dentate gyrus, the locus coeruleus, the hypothalamus, the substantia nigra, the cerebellum, the cortex and other limbic structures [108]. Other studies reported TRPV1 expression which was highly restricted to primary sensory ganglia with minimal expression in few brain regions which are adjacent to the caudal hypothalamus [107] (expression profiles and methods are summarized in Table 1). However several groups used TRPV1 agonists or antagonists as well as TRPV1 knock-out mice to define the role of TRPV1 channels in the CNS and reported versatile functions in different brain regions such as the hippocampus, the substantia nigra, the cortex or the hypothalamus. TRPV1 channels are not only activated by capsaicin but also by the CB1 agonist anandamide [109], other endovanilloids such as N-acyldopamines or the endogenous lipoxygenase derivates HPETE which are released for example in the hippocampus after mGluR1 activation [108]. Importantly, colocalization of TRPV1 and CB1 receptors was found in different mouse brain regions including the pyramidal cells of the hippocampus and basal glia [110, 111]. Regarding its cellular localisation, TRPV1 channels were detected in neuronal cell bodies, presynaptic terminals as well as in dendrites on postsynaptic spines [105, 106, 112, 113]. Furthermore, these channels are also present in pericytes and at the feet of astrocytes surrounding small vessels [105, 114].
TRPV2 channels are widely distributed in the brain compromising the colocalisation with TRPV1 in the cortex [19, 112, 115, 116]. TRPV3 mRNA was detected throughout the cortex, hippocampus, thalamus, striatum and cerebellum [117, 118]. TRPV4 mRNA is present in the hypothalamus, the cerebellum, basal ganglia, as well as in pyramidal neurons of the hippocampus [29, 119, 120]. Importantly, TRPV1-4 were also found in astrocytes [121, 122].
Rett syndrome (RTT) is severe X-linked neurodevelopmental disorder which is unique among genetic, chromosomal and other developmental disorders because of its extreme female gender bias, early normal development, and subsequent developmental regression with loss of motor and language skills. RTT is caused by heterozygosity for mutations in the X-linked gene
Importantly, TRPC3 and TRPC6 channel expression and function was significantly lower in the hippocampus and several other brain regions of Mecp2 mutant mice revealing a cellular phenotype certainly contributing to hippocampal dysfunction in Mecp2 mutant mice as well as Rett syndrome etiology. These results suggest that compounds which enhance BDNF release or boost TRPC3/TRPC6 channel function might be an interesting new preclinical concept which needs to be evaluated in Rett mouse models [124, 125].
Recent data suggests that TRPV1 channels might contribute to the pathophysiology of epilepsy. In the cortex and hippocampus from patients suffering from mesial temporal lobe epilepsy, the most common form of chronic and intractable epilepsy, TRPV1 mRNA and protein expression was significantly increased compared to healthy controls [126]. In a mouse model of temperal lobe epilepsy, these findings were supported [127]. The expression of TRPV1 in the dentate gyrus was significantly enhanced. Furthermore, capsaicin and anandamide significantly enhanced glutamate release in a TRPV1-dependent manner in mice with temperal lobe epilepsy [128, 129]. In contrast, the TRPV1 antagonist capsazepine reduced 4-aminopyridine-induced seizure-like activity in mice [128].
Beside TRPV1 channels, data from knockout mice point to a role of TRPC1/4/5 as well as for TRPC3/6 channels in the pathophysiology of epilepsy. Phelan et al. described a major role of TRPC1 and TRPC4 channels in the plateau potential of lateral septal neurons which show a high vulnerability to seizure-induced neuronal death as well as direct excitotoxicity by the application of group I mGluR receptor agonists [33].
TRPC3 channels are also discussed to play a “toxic” role in status epilepticus [46, 130]. After pilocarpine-induced status epilepticus in rats, TRPC3 expression was significantly enhanced in CA1, CA3 pyramidal neurons as well as dentate granule cells, whereas TRPC6 channel expression was reduced in these areas. Using two pharmacological approaches, first the inhibition of TRPC3 with the selective antagonist Pyr3 and second activation of TRPC6 channels with the TRPC6 activator hyperforin protected against neuronal damages following the status epilepticus [46].
TRP channels might be involved in several processes relevant for the pathophysiology of migraine such as altered central calcium homeostasis, multimodal sensory and pain perception, or central or peripheral sensitization. Therefore, a recent study investigated single nucleotide polymorphisms (SNPs) in TRP genes in 1040 patients and 1037 healthy controls in Spain. For TRPV1, a nominal association was found for TRPV1 rs 222741 in the overall migraine group, for TRPV3 a correlation with TRPV3 rs7217270 was detected in the migraine group with aura [131].
TRPV1 and TRPV3 channels might be involved in fear and anxiety [107, 132]. TRPV1 knockout mice showed decreased anxiety-related behavior in several behavior paradigms such as the elevated plus maze test or the light dark test [107, 132]. Furthermore, fear and stress reaction were also reduced in TRPV1 knockout mice [107]. Therefore, TRPV1 antagonists such as capsazepine were investigated when they were applied directly into the ventral hippocampus or the periaqueductal grey. In both studies capsazepine showed anxiolytic effects. Recent studies investigated if compounds which act on both TRPV1 as well as CB1 receptors might be more effective than selective TRPV1 blocker [133]. N-arachidonoyl-serotonin which blocks TRPV1 channels and indirectly activates CB1 receptors and Arachidonyl-2-chloroethylamide (ACEA) which activates both TRPV1 as well as CB1 receptors were investigated. N-arachidonyl-serotonin was more effective than arachidonyl-2-chloroethylamide in behavioral paradigms for anxiety [134, 135]. The TRPV1/CB1 agonist ACEA showed anxiolytic effects in a bell shaped dose dependency in a mouse model using electrical stimulation of a brain area, the medial dorsal periaqueductal gray, which has an important role in orchestrating anxiety- and panic-related responses [133, 136]. The panicolytic effects are dependent on CB1 receptors. Importantly, in higher concentrations ACEA loses its anxiolytic effect probably via TRPC1 activation. This assumption is supported by the finding that ACEA effects in higher concentrations can be unmasked by the addition of the TRPV1 antagonist capsazepine. TRPV1 blockade per se also showed panicolytic effects suggesting opposite functions for TRPV1 and CB1 receptors in the modulation of panic-like responses [136].
The evidence for the role of TRPC6 channels in depression comes from the active antidepressant constituent of St. Johns wort, hyperforin. Hyperforin resembles in its effects several classical antidepressants and neurotrophic factors such brain derived neurotrophic factor (BDNF) or nerve growth factor (NGF) [137-140]. Hyperforin inhibits neurotransmitter reuptake and improves synaptic plasticity ranging from increased neuritic outgrowth in PC12 cells to altered spine morphology in CA1 and CA3 neurons of the hippocampus via the activation of TRPC6 channels [137-139]. Recently, we showed that several signal cascades are involved in the alteration of synaptic plasticity such as Ras/MEK/ERK, PI3K/Akt as well as CAMKIV which finally result in CREB phorsphorylation [137]. In addition, enhanced CREB phosphorylation and TRPC6 channel expression was detected in the cortex but not the hippocampus after chronic hyperforin treatment for 4 weeks in adult mice [141]. However, hippocampal neurogenesis remained unchanged. Bouron et al. suggests that not only the hyperforin-mediated calcium influx but also its effects on intracellular zinc might be important for its antidepressant activity [142, 143]
Oxidative stress, mitochondrial dysfunction, and disrupted intracellular Ca2+ homeostasis are discussed to play a role in bipolar disorder (BD). TRPM2 channels, as a regulator and connector between reactive oxygen species (ROS) and intracellular Ca2+, seem to be implicated in bipolar disorder. In B-lymphocytes from patients, TRPM2 channel expression is elevated associated with enhanced intracellular Ca2+ levels [144]. In addition, several groups reported genetic association between several intronic and extronic single nucleotide polymorphisms in TRPM2 and BD [145-149]. In a recent study using B-lymphocytes from small group of patients (n = 6) suffering from bipolar disorder, no change in TRPM2 expression could be detected. However, they were more susceptible to oxidative stress when stimulated with H2O2 [150].
Multiple sclerosis is a neurodegenerative disease caused by chronic inflammation of the CNS. Schattling et al. recently demonstrated that TRPM4 channels are involved in the pathogenesis of multiple sclerosis by using TRPM4 knockout mice and inducing an experimental autoimmune encephalomyelitis (EAE) in these animals [91]. TRPM4 channels are located in hippocampal neurons from mice and humans as well as in the spinal cord and cortex. TRPM4 deficiency reduced overall disease severity. Importantly, deficiency or pharmacological inhibition of TRPM4 resulted in reduced axonal and neuronal degeneration without altering EAE relevant immune function. In addition, axonal TRPM4 expression in axons was significantly elevated in demyelinating white matter brain lesions of patients with multiple sclerosis in comparison to healthy controls. The authors further demonstrate that TRPV4 channels are involved in toxic effects of high glutamate levels which are a major contributor to neurodegeneration in multiple sclerosis.
Transient receptor potential (TRP) channels comprise a large family of non selective, calcium-permeable channel proteins which are activated and regulated by different mechanisms. TRP channels respond to secondary plant compounds as well as intracellular stimuli such as calcium, metabolites of the arachidonic acid or phosphatidylinositol signal transduction pathways. TRP channels sense environmental stimuli such as changes in temperature, osmolarity and pH and represent the molecular target of pheromones, taste and secondary plant compounds. The broad function of TRP channels in CNS physiology becomes apparent through their involvement in several psychiatric and neurological CNS disorders. This makes them an interesting topic for further research and drug development. The diversity of the chemical structures and the selectivity of the naturally occurring compounds modulating TRP channels show the possibility for pharmacological modulation of TRP channels and inspire the development of new synthetic structures for TRP channel interference at bench and bedside.
The Moon is a satellite of the Earth; therefore, it is the body closest to our planet. After the Sun, the Moon exerts the second greatest impact on the Earth. For these reasons, the Moon will occupy the first place in the future exploration of space.
Since the Moon always faces the Earth from one side, its main motion is orbital. Therefore, all the features of this motion are of interest, including its evolution over long time intervals. The first part of this chapter is devoted to this problem.
In the second part, prospects for further space research are considered. More than half a century of experience in this research has shown that the effectiveness of studies strongly depends on the resource base invoked for performing the studies. Of the celestial bodies, the Moon is the body most suitable for creating a base on it. The chapter discusses a wide range of issues related to the feasibility of creating such a base, its structure, functioning, and prospects for research on it.
When solving the problem of the evolution of the rotational motion of the Earth over millions of years [1], it is necessary to have data on the coordinates of bodies acting on the Earth at any time from this time interval. The Moon exerts two-thirds of the total influence exerted on the Earth’s rotational motion. The evolution of the Moon’s orbital motion is therefore an important component of the posed problem.
The evolution of the orbits of Solar-system bodies can be determined by solving the problem of interaction for those bodies. For solving this problem, a Galactica system was developed [2, 3, 4]. The accuracy ensured by this software is several orders of magnitude higher than the accuracy ensured by other similar systems [5, 6]; this made it possible to solve the problem of the evolution of the Solar-system over 100 million years [7]. This problem is solved in the barycentric coordinate system
The coordinate system and the main characteristics of the Moon’s orbit:
The Moon’s orbital period is very short compared to that of planets. Therefore, the oscillation periods of the parameters of the Moon’s orbit repeated many times over an interval of 10 thousand years. Therefore, with this interval, the evolution of the Moon’s orbit was studied during its 736 continuous revolutions around the Earth, which took place during 56.7 years.
The position of the Moon’s orbital plane,
In the initial epoch
Dynamics of the Moon’s orbital elements in the geocentric equatorial coordinate system: perigee radius
The period of revolution of the Moon around the Earth
Over the entire interval, the perigee angle
The inclination angle
When studying the orbits of the planets, we introduced the orbital axis
The orbital axes of all planets precess about the angular momentum of all Solar-system bodies. As a result of the study, it was found that the axis
Projections of the Moon’s precession axis
From the projection onto the
Thus, the Moon’s orbital axis precesses in a clockwise direction relative to the Earth’s orbital axis. The precession period
Such studies were carried out for each epoch following 10 thousand years over time intervals of 0 ÷ −2 million years and −98 ÷ −100 million years. As a result, it was found that in all these cases the Moon’s orbital axis
In the
Since the precession angle
Figure 3c shows, on a larger scale, the projection of the precessing orbital axis
As a result of an analysis, it was found that the endpoint of the vector
In the
Then, in the
where
The line in Figure 3c shows the trajectory of the motion along the hypocycloid, given by Eqs. (4) and (5), and the points are the projection of the motion of the Moon’s orbital axis. Both are perfectly coincident. Thus, the Moon’s orbital axis
The orbital axis
The dynamics of the inclination and precession angles,
Dynamics of the inclination and precession angles,
where
Changes in the Moon’s orbit occur in the form of two groups of motions. In the first group, changes occur in the orbital plane with variation of the following parameters: perigee radius
As it was noted above, the behavior exhibited by the Moon’s orbital elements was studied for the period of 736 its continuous revolutions in different epochs over the interval from 0 to 100 million years. In addition, the elements of the Moon’s orbit were investigated following the adoption of different initial conditions in the integration of the equations of motion using the Galactica program [7]. As a result of these studies, regularities of the dynamics of the elements were established, and the approximating dependences for them were chosen. The final form of the approximations was refined on a doubled interval from −736 to +736 revolutions, in which the meantime falls onto the epoch of December 30.0, 1949 with the Julian-day number
where
As it is evident from the graph
The eccentricity is approximated with two harmonics:
whose characteristics are given in Table 1.
0.0563331 | 0.0113634 | −2.19911 | 0.005637 |
6.91384 E−4 | −1.5708 | 0.03719 |
Coefficients in Eq. (8).
The perigee of the Moon’s orbit rotates counterclockwise and, in addition, it executes oscillatory movements, which were also approximated with two harmonics:
where
3.67159 | 0.088528 | 1.34024E−4 | 0.200529 | 2.19911 | 0.005637 |
−4.91312E−3 | 0.196967 | −0.188496 | 0.186006 |
Coefficients in Eq. (9).
The Moon’s orbital period
where
7.479277E−4 | 1.01403E−4 | 0.00385003 | 0.628319 | 0.00664039 |
0.00141509 | −1.41372 | 0.03719 |
Coefficients in Eq. (10).
Evidently, some parameters have identical oscillation periods. Perigee radius
As a result of studies, it was found that the precession angle
where
The inclination angle
where
The angles
As it is seen from Figure 1, the angle specifying the position of the ascending node of the Moon’s orbit is equal to the sum of two arcs,
By the sine theorem, in the triangle
and, therefore, the arc
In order to check the validity of the obtained approximations of the Moon’s orbital elements (13) and (16), we superimposed onto Figure 2 the calculated elements that were obtained using the Galactica program for the integration of the equations of motion. Figure 5 shows, over the entire interval of ± 56.7 years, the dynamics of the angles
Comparison of the dynamics of the angles
So, the dynamics of Moon’s orbital elements
As an example, Figure 6 shows the evolution of the average orbital period
Evolution, over the period of 2 million years, of relative averages for 736 revolutions of the deviations of Moon’s orbital parameters: period
where
As it is seen from Figure 6, the oscillation amplitude of the relative mean
The rest approximation parameters exhibit similar behavior. Similar results were obtained for the interval of −98 ÷ −100 million years. This allows us to conclude that, over the interval of 0 ÷ −100 million years, if there occur oscillations with longer periods than those used in our approximations, then the amplitude of such oscillations does not exceed a few percent of the considered oscillation amplitudes.
Thus, Eqs. (7)–(10), (13), (16) describe the evolution of Moon’s orbital elements
Figure 7 compares the Moon’s orbits calculated using this model with a time step of 1·10−4 years and numerical integration performed with the help of the Galactica program. The same orbital comparisons were made for the planets [9]. The orbits of the planets calculated by the mathematical model are no visual difference from the orbits obtained by numerical integration. As it is seen from Figure 7, such differences are observed for the Moon’s orbit. This is due to the shorter Moon’s orbital period compared to that of the planets. Nevertheless, this mathematical model of the Moon made it possible to solve the problem of the evolution of the Earth’s rotational axis with acceptable accuracy. Comparison of the results of this problem for 200 thousand years, solved with this model of the Moon’s orbit and without it, proved differences to be insignificant [1].
Comparison of the projections of the Moon’s orbit onto the equatorial plane
The orbital periods of the Moon, the precession of its orbital axis, and the rotation of the perihelion oscillate about the average values of these quantities. Over the interval of 113.4 years, the average values were designated as
Method | ||||
---|---|---|---|---|
Siderial years | Days | |||
Calculation | 7.479277∙10−2 | −18.60062 | 8.852804 | 27.318536 |
Observation | — | — | — | 27.321662 |
Relative difference, | — | — | — | −1.14∙10−4 |
Method | ||||
---|---|---|---|---|
Days | ||||
Calculation | 29.526938 | 27.551303 | 27.209129 | 27.315564 |
Observation | 29.530589 | 27.554550 | 27.21221 | 27.321582 |
Relative difference, | −1.24∙10−4 | −1.18∙10−4 | −1.13∙10−4 | −1.14∙10−4 |
Comparison of calculated and observed average durations of various months: sidereal
where the period
The period
where the period
The Draconic month with a period
where the period
A tropical month with a period
where the period
These periods, as calculated by Eqs. (18)–(21) and as evaluated from the observations of [10] are summarized in Table 4. The relative difference between the calculated and observed periods is expressed in terms of a parameter
As it is seen from Figure 2, the Moon’s orbital period
There are various proposals for research to be carried out on the Moon. Some of those proposals may prove useful, while others, not [11]. The Moon near the Earth is the only body close to it. Therefore, not counting the Earth, the Moon is the only body that can be used for the study and exploration of outer space. It seems that such activities should be carried out along three lines. It is necessary to study the Earth, the Sun, and outer space from the Moon. For this purpose, an Earth Service should be established on the visible side of the Moon, and a Space Service, on its opposite side. Solar exploration will be additionally performed by both Services.
The mission of the Earth Service is to continuously monitor and analyze all processes and phenomena that occur on the Earth. Observations should be carried out using optical means in all ranges of the spectrum. In addition, other available methods known in astronomy for measuring the physical characteristics of the Earth, such as the methods of radio astronomy,
All this will contribute to a safer and more stable habitation of humans on the Earth.
The Solar Service, located on both opposite hemispheres, will allow the observation of processes on the Sun in an almost continuous mode. Solar flares affect the dynamics of the Earth’s atmosphere, and they presently cause many dangerous atmospheric phenomena [12]. The Sun’s activity, manifested in the number of sunspots, varies periodically.
The study of solar processes will allow a more detailed understanding of the processes occurring on stars. The two Solar Services will host the equipment used for studying the Sun and stars from the Earth. The effectiveness of the use of this equipment on the Moon is expected to be much higher, as there is no cloudiness and no atmosphere there. Due to the small force of gravity, structures cumbersome on the Earth will appear weighing much less on the Moon.
The Space Service is the most important part of human activity on the Moon. The importance and relevance of its tasks to the solution of many challenging problems will permanently grow in time. At an early stage, this service will carry out all studies currently being carried out on the Earth with the help of Earth’s satellites. As this service evolves, these tasks will be supplemented with new ones that cannot be accomplished with the help of satellites. One of such tasks is the communication with spacecraft sent into deep space. The absence of atmosphere and intrinsic magnetic field on the Moon will make it possible to carry out such connections in a more stable manner.
What divisions should be included in these two services? Each service should consist of the following three departments: (1) Research Department; (2) Engineering Department; and (3) Greenhouse Department.
The task of the Research Department is to carry out works on the study of the Earth, the Sun, and space. The task of the Engineering and Technical Departments is to create the material base of the service and ensure its functioning. The task of the Greenhouse Department is to support life on the Moon, provide food for inhabitants, and to ensure life in all structures of the greenhouse economy.
At the first stage, the tasks of the Greenhouse Department will come as the main ones, since
Until the full-fledged functioning of the greenhouse economy begins on the Moon, research and engineering works will mainly be carried out with the help of automatic machines and mechanisms controlled from the Earth.
For moving on the Moon, it will be necessary to create walking and running vehicles. Animals on the Earth, two- and four-legged, can move at a decent speed comparable with the speed of wheeled vehicles. But an animal can move at this speed in off-road conditions. When moving, the animal observes its path and puts its foot on the ground taking into account all the circumstances arising at the point of contact with the ground. Modern means of observation, monitoring, and control make it possible to create a mechanical leg of a vehicle that will function no worse than the leg of the fastest animal. In further development, a vehicle with mechanical legs will reach in off-road conditions the speed of a wheeled vehicle on a good road.
Such vehicles with mechanical legs can be supplemented with mechanical arms or some legs can be provided with the function of arms. Mechanical arms will help the vehicle to extricate itself from emergency situations: when overturning, when driving in dangerous areas, etc. Control algorithms shall be developed for different situations and with time the reliability of such vehicles will approach 100%.
When driving on established routes, a vehicle with mechanical arms can clear the most disturbing obstacles out of the way. In this way, paths and roads for this transport will be created, along which the speed of movement will be increased.
Such vehicles, equipped with navigation aids, will be able to move with or without man. All works related to the delivery of goods will be executed without people. This will greatly simplify, and reduce the cost of, moving goods, since there will be no need in using life support systems for people.
Long-distance movements, for example, those between the Earth and the Space Services, will be performed using jet engines along ballistic trajectories. In jet engines on the Earth, fuel burns in an oxidizing agent, the combustion products acquire a high speed, and the jet stream propels the vehicle, for example, a spacecraft. In lunar jet engines, lunar sand and dust will be used as the jet substance. The jet vehicle must possess the energy required to impart the speed of the jet stream to this material. This energy can be the electrical energy stored in batteries. The batteries will be charged by solar panels during the lunar day.
The acceleration of the substance can be carried out electrically. For example, a charge of one sign can be imparted to a bulk material, which then enters an inter-electrode space with a high voltage to undergo acceleration. In the mechanical method, the bulk material is fed to a rotating device to acquire the required speed. In this case, in order to prevent the vehicle from rotating, it is necessary to have paired devices rotating in different directions.
As the bulk material, lunar regolith can be used, which, apparently, includes terrestrial analogs in terms of its granulometric composition such as dust, powder, sand, and sandy loam.
The issue of obtaining and storing energy is a special problem that requires careful study. Apparently, in the non-polar regions of the Moon, solar energy will be sufficient. Solar panels can provide electricity that needs to be stored for the Moon night. For heating during the night and for cooling during the day, respectively heat and cold accumulators must be used. Electricity can also be generated based on the temperature difference between the lunar surface and the constant-temperature layer beneath it. This temperature difference exists both during the day and at night. Apparently, Stirling engines can be used here for doing work and for generating electricity.
For the creation of the Earth and Space Services, various materials and substances are needed. Consider what is required for supporting life on the Moon.
Where can we get water? During lunar days, the Moon’s surface gets heated, and the water boiled away and evaporated. It is necessary to study the distribution of temperature over the lunar surface. Somewhere closer to the poles, a negative temperature can be found. It might be possible to find ice there.
In equatorial and middle latitudes, the temperature of the lunar surface varies from hundreds of Celsius degrees during the day to hundreds of degrees below zero at night. But with depth, the layer of variable temperature must vanish, and a constant temperature must establish. How low is this temperature? If the temperature is negative, then there may be ice found at this depth.
Thus, in order to find water, one has to carry out temperature studies of the Moon, both in-depth and over the surface.
Where can we get air? On the Earth, air contains 80% of nitrogen and 20% of oxygen. There are also small amounts of other gases. Apparently, many of them are not necessary.
There are no ready air and component gases (nitrogen and oxygen) on the Moon. Therefore, they must be obtained from substances available on the Moon. It is necessary to study the composition of lunar rocks. Then, people on the Earth must develop technologies for the extraction of nitrogen and oxygen from these rocks. Subsequently, the composition of the artificial air can be optimized with the help of plants and algae. Among them are those that give off oxygen as well as other gases.
For the construction of a greenhouse, structural materials, metals, and various substances are needed. It is impossible to get them from the Earth. From the Earth, it will be necessary to transport finished products, complex instruments and tools, machines, and similar products, which are impossible to manufacture on the Moon. All necessary materials and substances must be extracted from minerals available on the Moon. That is why the Moon’s geology must be well studied. On its basis, processes on the transformation of lunar minerals into necessary materials and substances should be developed on the Earth.
Buildings on the Moon will require a lot of spent effort, money, and time. Therefore, they must be durable with a service life amounting to hundreds of years. In this regard, it will be necessary for people on the Moon to protect themselves from natural disasters. This can be soil creeps on slopes, rockfalls, meteorite falls, etc. Some of such processes and events can pose no real threat. That is why, before the start of construction, it will be necessary to perform a study of possible risks and their occurrence probabilities. As for the meteorite danger, its reality is beyond doubt, since the entire surface of the Moon, like that of all celestial bodies, is dotted with meteorite craters. Therefore, this threat must be treated with close attention. Apparently, it is necessary to conduct experimental observations on the probability, composition, and characteristics of meteorites falling onto the Moon. For this purpose, it is possible to spread a screen on the Moon’s surface with means for observing and controlling the fall of meteorites. Information from such devices must be transmitted to Earth. Observations should be made over several years. They will allow scientists to obtain data on meteorite hazards, which is necessary for the design of buildings. There should be two such sites in the places of proposed construction: one on the visible side of the Moon, and the other on the opposite side.
Over the long service life of structures, there will always be a danger of being hit by large meteorites. Therefore, a vitally important part of the greenhouse must be created below the Moon’s surface. Apparently, the best option would be the creation of each service near a rock hill. The greenhouse farm will be located outside the hill, with its all vitally important systems being hidden in hollow rooms inside the hill. The top of the hill will provide the reliable protection of such systems from relatively large meteorites. The greenhouse should be made sectioned. Then, in the event of a depressurization having occurred at some section as a result of a meteorite hit, the remaining sections will automatically be cut off from the damaged section and continue to function.
Services on the Moon will be created in the interests of all mankind. However, there are states on Earth the relations among which cannot be called friendly. Mutual threats are possible and wars to destroy each other are not ruled out. This situation may not radically change in the next hundreds of years. Therefore, principles to govern the relations between people of the Earth during their activities on the Moon must be formulated. Based on the conditions necessary for the successful functioning of two services on the Moon, let us try to formulate some of those principles.
First, each state has the right to take part in the creation and functioning of these services, and it will share the results obtained.
Secondly, since there are two services, it makes sense to form two groups of states, one being responsible for the service on the visible side of the Moon, and the other, on its backside.
Thirdly, having obtained permission, the representatives of one group of states will have the right to visit the territory of the service shared by the second group of states.
Fourth, each group of states shall share its achievements and results with the members of the other group at no cost.
Fifth, unfriendly and hostile relations among states on the Earth shall not be practiced by representatives of such states on the Moon.
Those who call to violate this principle will be subject to capital punishment with no statute of limitations.
Mankind already has experience of such cooperation gained in the study of Antarctica, in the Apollo-Soyuz project, and in the activities at the International Space Station.
Moon exploration began 50 years ago by the Soviet Union and the United States. Other countries now take part in it.
Therefore, it is necessary to conduct an international discussion of the problem of Moon exploration by all interested parties. The result of this discussion should be the establishment of an International Committee for Moon Exploration.
In this project, all the goals and objectives discussed above will be concretized. This will allow different countries to unite their efforts. The International Committee will have the task of coordinating these studies, analyzing and summarizing their results, and setting further tasks.
This work will contribute to the rapprochement of the individual parties, uniting them in the implementation of large projects. This cooperation will further lead to the consolidation of collaboration teams necessary for the creation of Earth and Space services.
One of these preliminary tasks is the creation of a Moon satellite. The satellite is needed as an intermediate station for flights from Earth to the Moon and back. In addition, a satellite is needed to connect the Space Service with the Earth, and the Earth and Space services with each other.
Further development of the International Committee for Moon Exploration will turn it into main mankind’s organization on the exploration of the Moon and lunar works.
When mankind starts establishing services on the Moon, the task may be set to provide the Moon with a long-term satellite. Previously, we have performed trajectory calculations for transforming the Apophis and 1950DA asteroids into Earth’s satellites [14]. The task here is to choose an asteroid suitable for making it a Moon satellite. Apparently, the orbit of such a satellite should be circular or having a small eccentricity and a semi-major axis about 5000 km long. That is, the spacing between such an asteroid and the Moon should be equal to the above distance. The satellite’s orbit must lie in the Moon’s orbital plane. Such a satellite will increase the reliability of movements between the Earth and the Moon.
In astronomy, various methods are used to determine the distance from the Earth to astronomical objects. The most reliable one is the triangulation method, in which the angles of observation of a star from opposite points in the Earth’s orbit are measured. The angles can be determined from the displacement of a star over the celestial sphere against the background of more distant stars. In this way, one can measure the distance to objects located at a distance of 20 parsecs (pc). In this case, the base distance is the semi-axis of the Earth’s orbit
One can increase the base by placing one of the observation points on a spacecraft launched from the Earth along a hyperbolic orbit. The location of the star, observed on the spacecraft at some distance
We assume that a spacecraft is launched at point
Trajectories of a triangulation spacecraft for measuring distances to stars:
The views of the starry sky seen from the spacecraft in the direction of the
Parameters | Parameter values | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1.03 | 2.12 | 3.08 | 4.05 | 5.02 | 10.1 | 15.1 | 20.4 | 25.4 | 30.4 | |
7 | 14.4 | 20 | 26 | 32 | 63 | 93 | 125 | 155 | 185 | |
140 | 280 | 400 | 520 | 640 | 1260 | 1860 | 2500 | 3100 | 3700 |
The distance
Range measurements are possible for those distances
Distance
The data gained in this work were obtained while performing research activities that have been conducted during two decades at the Institute of Earth’s Cryosphere, Tyumen SC of SB RAS, Federal Research Center. In recent years this research project has been carried out under Contract Agreement No. 121041600047-2 with RAS. The results are based on the solution of the interaction problem for Solar-system bodies which was obtained using the supercomputers of the Shared-Use Center at the Siberian Supercomputer Center, Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia. This chapter was read by my son Leonid J. Smulsky and made a number of useful suggestions.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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\n\n\n\nAt IntechOpen we realize that exceptional circumstances can occur, resulting in a request for a refund. We will honor all justified requests in the specific instances outlined in our Refund Policy.
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\n\nIf there are supplemental materials to the chapter, these will be published at the time the final book is published online.
\n\nReaders and Authors can notify us if they find any errors in the works published under Online First. All major errors will be accompanied by a separate correction notice, erratum or corrigendum (Retraction and Correction Policy.)
\n\nIntechOpen books are available online by accessing all published content on a chapter level.
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Secondly, we calculate there megalopolises to obtain the vulnerability of each city in 2018 Sex index. The results show that the central cities and economically underdeveloped cities of the three megalopolises are relatively vulnerable areas in the urban agglomerations, and areas have low sensitivity and high response. Finally, policy suggestions for megalopolis are given to improve the adaptive capacity of tackling climate change. The innovation of this chapter is to use spatial data to comprehensively evaluate and analyze the vulnerability, and to realize visualization in the map, which better reflects the distribution law and proposes a response to megalopolis vulnerability.",book:{id:"9838",slug:"design-of-cities-and-buildings-sustainability-and-resilience-in-the-built-environment",title:"Design of Cities and Buildings",fullTitle:"Design of Cities and Buildings - Sustainability and Resilience in the Built Environment"},signatures:"Tao Ma, Nairong Tan, Xiaolei Wang, Hao Wang and Mingxi Zhou",authors:[{id:"322664",title:"Prof.",name:"Tao",middleName:null,surname:"Ma",slug:"tao-ma",fullName:"Tao Ma"},{id:"328882",title:"MSc.",name:"Nairong",middleName:null,surname:"Tan",slug:"nairong-tan",fullName:"Nairong Tan"},{id:"328887",title:"Ms.",name:"Xiaolei",middleName:null,surname:"Wang",slug:"xiaolei-wang",fullName:"Xiaolei Wang"},{id:"332546",title:"MSc.",name:"Hao",middleName:null,surname:"Wang",slug:"hao-wang",fullName:"Hao Wang"},{id:"332548",title:"MSc.",name:"Zhou",middleName:null,surname:"Mingxi",slug:"zhou-mingxi",fullName:"Zhou Mingxi"}]}],onlineFirstChaptersFilter:{topicId:"783",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. 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He collaborates with the Environmental Resources Analysis Research Group (ARAM), University of Extremadura (UEx), Spain; VALORIZA - Research Center for the Enhancement of Endogenous Resources, Polytechnic Institute of Portalegre (IPP), Portugal; Centre for Tourism Research, Development and Innovation (CITUR), Madeira, Portugal; and AQUAGEO Research Group, University of Campinas (UNICAMP), Brazil.",institutionString:"University of Johannesburg, South Africa and WSB University, Poland",institution:{name:"University of Johannesburg",institutionURL:null,country:{name:"South Africa"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:9,paginationItems:[{id:"81493",title:"Rust Disease Classification Using Deep Learning Based Algorithm: The Case of Wheat",doi:"10.5772/intechopen.104426",signatures:"Shivani Sood, Harjeet Singh and Suruchi Jindal",slug:"rust-disease-classification-using-deep-learning-based-algorithm-the-case-of-wheat",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"81428",title:"Observatory of Sustainable Development in Postgraduate Study Programs in Baja California",doi:"10.5772/intechopen.104641",signatures:"Rodolfo Martinez-Gutierrez, Maria Marcela Solis-Quinteros, Maria Esther Ibarra-Estrada and Angel Ernesto Jimenez-Bernardino",slug:"observatory-of-sustainable-development-in-postgraduate-study-programs-in-baja-california",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"81235",title:"Global Food System Transformation for Resilience",doi:"10.5772/intechopen.102749",signatures:"Jasper Okoro Godwin Elechi, Ikechukwu U. 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