Comparison of studies measuring reticulated platelets and immature platelet fraction in healthy newborns.
\r\n\t
",isbn:"978-1-80356-420-3",printIsbn:"978-1-80356-419-7",pdfIsbn:"978-1-80356-421-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"f188555eee4211fc24b6cca361983149",bookSignature:"Dr. Kim Ho Yeap",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11509.jpg",keywords:"Inductive Coupling, Resonant Inductive Coupling, Magnetic Coupling, Magnetic Resonance, Transmitter, Receiver, Rectenna, Antenna, Induction Coil, Stationery Charging, Dynamic Charging, Rectifier",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 25th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",remainingDaysToSecondStep:"12 days",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Kim Ho Yeap is a senior member of the IEEE, a Chartered Engineer registered with the UK Engineering Council, a Professional Engineer (PEng) registered with the Board of Engineers Malaysia, and an ASEAN Chartered Professional Engineer. In 2008 and 2015 he underwent research attachment at the University of Oxford (UK) and the Nippon Institute of Technology (Japan). Dr. Yeap has been given the university teaching excellence award and 21 research grants. He has published more than 100 research articles.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"126825",title:"Dr.",name:"Kim Ho",middleName:null,surname:"Yeap",slug:"kim-ho-yeap",fullName:"Kim Ho Yeap",profilePictureURL:"https://mts.intechopen.com/storage/users/126825/images/system/126825.jpeg",biography:"Dr. Kim Ho Yeap is an associate professor at Universiti Tunku Abdul Rahman, Malaysia. He is a senior member of the IEEE, a Chartered Engineer (CEng) registered with the UK Engineering Council, a Professional Engineer (PEng) registered with the Board of Engineers Malaysia, and an ASEAN Chartered Professional Engineer. He received his BEng (Hons) in Electrical and Electronics Engineering from Universiti Teknologi Petronas in 2004, his MSc in Microelectronics from Universiti Kebangsaan Malaysia in 2005, and his PhD from Universiti Tunku Abdul Rahman in 2011. In 2008 and 2015, respectively, he underwent research attachment at the University of Oxford (UK) and the Nippon Institute of Technology (Japan). He is the external examiner and external course assessor of Wawasan Open University. He is also the editor-in-chief of the i-manager’s Journal on Digital Signal Processing. He has also been a guest editor for the Journal of Applied Environmental and Biological Sciences and Journal of Fundamental and Applied Sciences. In addition, he has been given the university teaching excellence award and 21 research grants. He has published more than 100 research articles (including refereed journal papers, conference proceedings, books, and book chapters), which are mostly related to electromagnetics. Among his notable publications—and those of which he is most proud—are the report on the design of the receiver optics used in the Atacama Large Millimeter/Submillimeter Array telescope and the formulations that rigorously describe wave propagation in lossy waveguides.",institutionString:"Universiti Tunku Abdul Rahman",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Universiti Tunku Abdul Rahman",institutionURL:null,country:{name:"Malaysia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444315",firstName:"Karla",lastName:"Skuliber",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/444315/images/20013_n.jpg",email:"karla@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"7617",title:"Electromagnetic Fields and Waves",subtitle:null,isOpenForSubmission:!1,hash:"d87c09ddaa95c04479ffa2579e9f16d2",slug:"electromagnetic-fields-and-waves",bookSignature:"Kim Ho Yeap and Kazuhiro Hirasawa",coverURL:"https://cdn.intechopen.com/books/images_new/7617.jpg",editedByType:"Edited by",editors:[{id:"126825",title:"Dr.",name:"Kim Ho",surname:"Yeap",slug:"kim-ho-yeap",fullName:"Kim Ho Yeap"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"53450",title:"Reference Intervals of Platelets, Lymphocytes and Cardiac Biomarkers in Umbilical Cord Blood",doi:"10.5772/66458",slug:"reference-intervals-of-platelets-lymphocytes-and-cardiac-biomarkers-in-umbilical-cord-blood",body:'\nObtaining admission laboratory studies is necessary to provide appropriate neonatal care. As a general rule, the blood drawn for laboratory testing should not exceed 5% of the total blood volume per draw; thus, in neonates and infants, a less‐than‐optimal amount of blood may be available for testing. Approximately 1.5 – 4 mL of blood drawn for admission blood test may cause iatrogenic anemia to neonates especially in extremely low birth weight infants [1, 2]. Umbilical cord blood (UCB) is remained blood in the placenta and attached umbilical cord after the birth of baby. Several studies suggest that UCB could be an alternative source for admission of blood tests in neonates [1, 3, 4]. Especially, very low birth weight infants who typically have greater phlebotomy blood loss on the first day of life than any other day during their hospitalization would benefit most from admission laboratory studies being obtained from UCB [5, 6].
\nAt birth, full‐term newborns show relative polycythemia, macrocytosis, and marked polychromasia with nucleated red blood cells (RBCs) [7, 8]. The red cell distribution width (RDW) is elevated, showing anisocytosis, compared with adult standards. Full-term newborns have a high white blood cell (WBC) count with relative transient neutrophilia at birth while soon after birth, neutrophils gradually decrease and lymphocytes become major population in neonate\'s peripheral blood. This neutrophilia may arise from bone marrow mobilization under stress during labor, and these WBCs show shift‐to‐left neutrophils such as metamyelocytes, myelocytes, and even circulating blasts [9, 10]. The platelet counts are similar to the older children and adults. Neonatal thrombocytopenia is defined as a platelet count less than 150 × 109/L in any neonate of a viable gestational age. Thrombocytopenia is one of the most common hematological abnormalities except iatrogenic anemia in neonates [11, 12].
\nDuring the pregnancy, human placenta forms an imperfect barrier, allowing bidirectional passage of soluble antigens and cells between a mother and a baby without any mixing between the two blood supplies [13]. This results in the presence of fetal cells in the maternal circulation, known as fetal microchimerism, and maternal cells in the fetal circulation, known as maternal microchimerism [14]. Maternal microchimerism was first described in 1963 by Rajendra G. Desai who identified maternal leukocytes and platelets in UCB [15]. This bidirectional trafficking of cells begins at seven to 16 weeks, increases steadily after 24 weeks, and reaches a peak at parturition [16]. At delivery, maternal microchimerism has been reported in 42% of normal pregnancies [13]. For this, microchimerism does not occur in all pregnancies, altered maternal‐fetal bidirectional passage has been associated with disruption of the feto‐maternal interface, and the biologic role of this bidirectional passage is unclear. This passage is implicated in development of the fetal immune system [17]. Substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the immune system, the development of CD4+CD25highFOXP3+ regulatory T cells (Tregs), which suppresses fetal antimaternal immunity.
\nUCB is a rich source of hematopoietic cells or precursors to blood cells. Since the first UCB stem cell transplantation in 1988 to treat a child with Fanconi’s anemia, UCB has been used as an important source of hematopoietic stem cell transplantation [18]. UCB could be collected at birth without any harm to the newborn infant. UCB cells have many theoretical advantages as grafts for stem cell transplantation because of the immaturity of newborn cells and immaturity of the immune system at birth. These properties should decrease the alloreactive potential of the lymphocytes and should reduce the incidence and severity of graft‐versus‐host disease after human leukocyte antigen (HLA) -matched or HLA‐mismatched transplantation [19]. The recovery rate of colony‐forming unit correlated significantly with platelets as well as leukocytes, RBCs, mononuclear cells, CD34+ leukocytes, and viable leukocytes [20]. Detection of abnormal levels of platelets, leukocytes, RBCs, mononuclear cells, CD34+ leukocytes, and viable leukocytes could be one of UCB screening tests available.
\nThe interpretation of results of laboratory tests includes the comparison between the reported values versus documented reference intervals. The reference intervals are defined as values obtained by measurement of a particular type of quantity on a reference individual who selected for testing on the basis of well‐defined criteria who is considered being in healthy state from general population [21]. For these reasons, establishment of reference intervals for blood tests such as complete blood counts and biomarkers in UCB is crucial for clinical laboratory tests. We discuss the reference intervals of platelets, lymphocytes, and cardiac biomarkers in UCB.
The production of health‐associated reference values must be implemented in accordance with a well‐defined protocol. The Clinical Laboratory Standards Institute (CLSI) offers a protocol for determining reference intervals that meet the minimum requirements for reliability and usefulness related to quantitative clinical laboratory tests [21]. The CLSI suggested a protocol outline for obtaining reference values and establishing reference intervals. First, researchers should establish a list of analytical interferences and sources of biological variability from medical and scientific literatures. Then, they must establish selection and partition criteria and an appropriate questionnaire designed to reveal these criteria in the potential reference individuals. An appropriate written consent should be signed by legal guardians of neonates. Researchers have to categorize the potential reference individuals based on the results of questionnaire and health assessments and exclude individuals based on the exclusion criteria. For UCB, gestational age, birth weight, maternal age, maternal health, and maternal history of medical, smoking, and alcohol consumption are important.
\nThe reference interval is defined as the internal between and including two numbers, an upper and lower reference limit, which are estimated to enclose a specified percentage (usually 95%). For most analytes, the lower and upper reference limits are estimated as the 2.5th and 97.5th percentiles of the distribution of test results for reference populations. To decide on an appropriate number of reference individuals, in consideration of desire confidence limits, the CLSI suggests that a minimum of 120 reference values for 90% confidence limits, 146 observations for 95% confidence limits, and 210 reference values for 99% confidence limits. It is necessary to define whether the sample should be arterial or venous UCB in a manner consistent with the routine practice for patient specimens. Inspection of the reference value data, preparing a histogram, and identifying possible data errors and/or outliers are essential to evaluate the distribution of data. Furthermore, partitioning into subclasses for separate reference intervals should be considered if appropriate according to gestational age, gender of neonates, and maternal age.
\nFor difficulties of sample obtaining, it is not easy to establish reference intervals of parameters for neonates according to the CLSI guideline. Even published reference intervals using neonates’ peripheral blood or UCB are very useful and informative for clinical laboratory tests, physicians should keep in mind that some of published reference intervals did not satisfy the CLSI guideline for sample collection.
The first morphologically visible platelets appear in the fetal circulation at seven to nine weeks, and the platelet counts reach adult levels before 18th gestational week [2, 22]. The intrauterine thrombocytopenia could diagnose through fetal blood sampling after 18th gestational week [2]. The platelet counts are constant at birth and in neonatal period and compatible to the count in adult. Neonatal thrombocytopenia has been defined traditionally as a platelet count less than 150 × 109/L. This definition was challenged by recent studies. Large‐scale study presented that platelet counts of preterm neonates born before 35 weeks gestation were significantly lower than those that were of late-preterm and preterm infants [23]. Wasiluk [24] reported the platelet count is found to be decreased in preterm and late-preterm newborns. The platelet counts were increasing with completed weeks of gestation and birth weight. Decreased platelet count in preterm could be considered as immaturity of thrombopoiesis and impaired process of megakaryopoiesis characterized by the rapid proliferation of megakaryocyte precursors and full cytoplasmic maturation of megakaryocytes leading to the production of high number of platelets. Levels of thrombopoietin and reticulated platelets (immature platelet fraction, IPF) could reveal the megakaryopoiesis of fetus and neonates.
\nExcept iatrogenic anemia, thrombocytopenia is the most common hematological abnormality in neonates [11]. Incidence of thrombocytopenia is 1–5% in newborns at birth [25–27]. Thrombocytopenia may be caused by feto‐maternal and neonatal conditions such as impaired platelet production, consumption and sequestration, and combined mechanisms [28–31]. Platelet transfusion is associated with several risks including infection, transfusion‐related acute lung injury, transfusion‐associated circulatory overload, alloimmunization, allergic reaction, and other complications. Therefore, platelet should be given when clearly clinically indicated [31, 32]. Reference values for normal platelet counts, especially lower limit, are important to diagnose thrombocytopenia. In particular, there is a need for supplementary parameters in order to evaluate the megakaryopoiesis and bleeding risk [31].
\nIPF is newly released from fetal liver or the bone marrow and containing high amount of ribonucleic acid (RNA). Thiazole orange, a fluorescent dye, is characterized by binding to nucleic acid, particularly RNA, and flow cytometric analysis of platelets after staining with thiazole orange reflects the activity of megakaryopoiesis in the bone marrow [33]. Measuring IPF of the systemic circulation is a novel parameter to estimate the megakaryopoiesis and can be useful to recognize quickly as having platelet destruction or bone marrow failure in a neonate with low platelet count [34]. Measuring IPF may potentially avoid the need for bone marrow examination. Increased IPF% or normal IPF number (IPF#) is considered in the case of platelet consumption in thrombocytopenia, whereas normal or decreased IPF% and IPF# is considered in the case of bone marrow failure in thrombocytopenia. Today, IPF can be measured on fully automated routine hematology analyzers (XE‐2100 and XN modular system; Sysmex, Kobe, Japan) [35]. Establishment of reference intervals for platelet and IPF in neonates is essential for diagnosis of neonatal thrombocytopenia, for facilitating the clinical usefulness of IPF, and for clear indication of transfusion. Table 1 shows the comparison of studies measuring IPF in healthy subjects. The new automated hematology analyzer, XN modular system, demonstrated remarkable higher and broader reference intervals for platelets and IPF compared with XE‐2100 [36]. For these differences, clinical laboratories should establish or verify reference intervals for platelets and IPF according to their own instrument.
Study | Gestational age (week) | Number of participants | Platelet counts (×109/L) | Parameter | Method or instruments | RP% or IPF% | Absolute RP or IPF counts (×109/L) |
---|---|---|---|---|---|---|---|
[67] | 36 | 39 | 246 ± 65 | RP | Flow cytometry | 4 ± 2.4% | 10.5 ± 8.7 |
[68] | 28 ± 2.5 | 37 | 150–450 | RP | Flow cytometry | 2.7 ± 1.6% | NA |
[69] | 38–41 | 72 | 316.96 ± 60.76 | RP | Flow cytometry | 1.65 ± 0.95% | |
[70] | 36.3 ± 3.7 | 456 | 150–450 | IPF | XE‐2100, Sysmex | 4.3 (95% CI 0.7–7.9) | NA |
[34] | 39.3 (38.0–41.6) | 133 | 191–392† | IPF | XE‐2100, Sysmex | 0.7–3.8† | 1.94–9.69† |
[36] | 39.0 (38.0–41.3) | 140 | 174–405† | IPF | XN, Sysmex | 1.0–4.4† | 2.9–12.8† |
Comparison of studies measuring reticulated platelets and immature platelet fraction in healthy newborns.
IPF, immature platelets; NA, not available; RP, reticulated platelets.
† Reference interval.
Note: Data were expressed as mean ± standard deviation, range, or median (range).
Lymphocytes in UCB are naïve and immature, are enriched in double‐negative CD3+ cells, and produce fewer cytokines [19]. Lymphocyte counts, T cell and B cell, can reflect status of immune system in fetus and neonates. B‐ and/or T‐cell lymphocytopenia could be noted in some viral infection but also in Wiskott‐Aldrich syndrome, X‐linked agammaglobulinemia, and severe combined immunodeficiency [37–40]. To define abnormality of lymphocyte counts, quantitation of the lymphocytes and their subtypes with flow cytometry and establishment of reference interval are necessary.
\nCirculating T cells in the fetus and neonate are fundamentally different from naïve adult T cells such as containing high concentration of T‐cell receptor excision circles (TRECs), high cell turnover, increased susceptibility to apoptosis, and presence of CD25+ regulatory T lymphocytes (Tregs), and so on [41]. Natural Tregs originate in the thymus and are specific for self‐antigens presented by thymic epithelial cells [42]. Maternal cells commonly cross the placenta and engraft into fetal circulation and tissues in uterus, resulting in maternal microchimerism [17, 43]. Naturally acquired microchimerism can contribute to autoimmune diseases. In particular, maternal microchimerism has been studied in systemic sclerosis, dermatomyositis, and neonatal lupus [43]. Especially, Tregs in UCB may contribute to maintain the immune homeostasis in the feto‐maternal relationship, and the presence of Tregs would be essential to prevent immune dysregulation in fetus and neonates [17, 44]. Fetal Tregs are known to regulate fetal immune responses against noninherited maternal alloantigens. During labor, neonatal immune system faces big challenge. The tolerogenic immune state of the semi‐allogeneic fetus should switch over to prevent potentially damaging inflammation or infection. In immunosuppressive state, several cells such as helper T cells with a specific cytokine profile, neutrophilic myeloid‐derived suppressor cells, erythroid CD71+ cells, and Tregs are potential mediators [45, 46].
\nInfection of newborn and infants is a major healthcare challenge with global mortality in excess of one million lives especially in very low-birth-weight preterm infants [47]. Preterm infants are highly susceptible to invasive infections, which are leading causes of mortality and long‐term morbidity. Treg levels and gestational age inversely correlated in several studies [48–50]. Preterm infants have higher Treg levels than full‐term newborns. Tregs inhibit antimicrobial immune responses. The T cell immune response in preterm infants is supposed to be dysregulated and affected by prenatal factors including intrauterine inflammation and maternal characteristics. This dysregulation of T cell immunity could lead to ineffective clearance of pathogens [49]. Tregs have two populations (CD31+ and CD31-), and the ratio alteration of these populations is associated with different intra‐ and/or extra‐uterine milieu. The CD31- Treg levels are significantly higher in UCB of preterm pregnancies associated with inflammation and prenatal lipopolysaccharide exposure. The alteration of homeostatic composition of Tregs subsets related to reduced
The frequency of regulatory T cells (Tregs) is higher in preterm infants than in term infants. Box-plots [median, interquartile range (IQR), 95% confidence interval (CI)] describe the frequencies of Tregs across groups of different gestational age. Adapted from [
In spite of the growing attention on the importance of Tregs in UCB and neonates, the distribution of Tregs in normal UCB or healthy neonates was not well‐known. Table 2 showed the comparison of studies measuring lymphocyte subsets and Tregs in healthy subjects. Each study showed different values for lymphocyte subsets and Tregs. For these differences, clinical laboratories should establish or verify reference intervals for lymphocyte subsets and Tregs.
Study | Gestational age (week) | Number of participants | Helper T cells (CD3+/CD4+, %) | Cytotoxic T cells (CD3+/CD8+, %) | B cells (CD19+, %) | NK cells (CD3‐/CD16+/CD56+, %) | Regulatory T cells (CD4+/CD25high/FOXP3+, %) |
---|---|---|---|---|---|---|---|
[71] | Healthy full‐term | 98 | 46.7 (40.2–61.9) | 16.3(14.3–21.3) | 11.5 (7.6–15.5) | NA | 5.2 (3.5–7.0)¶ |
[72] | NA | 22 | NA | NA | 17.2 (13.2–25.4) | NA | NA |
[73] | NA | 38 | 44 (34–57)‡ | 17 (11–30)‡ | 16 (9–23)‡ | 16 (6–28)‡ | NA |
[44] | 38.0–41.3 | 120 | 15.40–70.06† | 9.65–34.28† | 4.50–29.59† | 1.42–28.03† | 0.35–9.07† |
[74] | ≥35 | 18 | 41 (26–62) | 14 (5–37) | 10 (3–30) | 22 (8–62) | 7 (4–13)¶ |
[75] | NA | 53 | 28.9 (11.4–40.3)‡ | 11.8(6.1–18.3) | 15.2 (9.3–22.0) | 18.2 (8.6–28.2) | 16.7 (12.3–23.8)§ |
Comparision of studies measuring lymphocyte subsets and Tregs in healthy subjects.
† Reference interval.
‡ Median values with 10th and 90th percentiles.
§ CD4+/CD25+.
¶ CD4+/CD25+/CD127-.
Note: Data were expressed as mean ± standard deviation, range, or median (range).
Congenital heart disease or defect (CHD) is the most common birth defect in newborns [51]. Critical CHDs require intervention or surgery in the first year of life. Echocardiography is a definitive diagnostic tool of CHD and provides hemodynamic and anatomic information of heart. Twenty‐five to 30% of children, however, with critical CHD are not detected by fetal echocardiography until after discharge from the birth hospitalization [52]. Cardiac biomarkers are essential to evaluate heart function and give information of myocardial injury, necrosis, or myocardial stretch. Concentrations of cardiac troponins, troponin I (TnI) or troponin T (TnT), are elevated in myocardial necrosis and myocardial infarction. Troponins are also increased in patients with heart failure and myocarditis. Elevated concentration of brain‐type natriuretic peptides (BNP) or N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) is related to myocardial stretch and left ventricular dysfunction and can be used for screening and prognosis of heart failure (HF) [53, 54]. Suppression of tumorigenicity 2 (ST2), a member of the interleukin (IL)‐1 receptor family, has two isoforms: transmembrane ST2 and soluble ST2 (sST2). IL-33 reduces fibrosis and hypertrophy of myocardium, and preserves ventricular function. The sST2 plays a role as a decoy receptor of IL‐33, and binding of IL‐33 and sST2 inhibits the beneficial and protective effect of IL‐33 on the heart. The concentration of sST2 is elevated in patients with HF and is also associated with the prognosis of acute and chronic HF [55].
\nMany studies reported that NT‐proBNP or BNP was elevated in peripheral blood or UCB with neonates with CHD [56]. A few studies presented the distribution of TnI or TnT in neonates or UCB [57–60]. The distribution and association of sST2 with CHD have not been investigated yet. There are no current guidelines for their routine use in children. The levels of NT‐proBNP were significantly increased in UCB of neonates with CHD compared with that in the UCB of control group. In addition, the levels of NT‐proBNP were significantly increased in the neonates with tight ventricular outflow tract obstruction without a ventricular septal defect compared with that in the other groups (Figure 2). Moreover, there was significant difference between survivors and non‐survivors within one‐year of birth [61]. Hydrops fetalis is fluid collection in multiple body compartments in fetus because of immune or non-immune mechanism. Congestive heart failure or cardiac dysfunction has been described as one of the major mechanisms for nonimmune hydrops fetalis. The levels of NT‐proBNP in cases with hydrops of cardiac origin were higher than those in cases with hydrops of non-cardiac origin. However, levels of TnT did not differ though the causes of hydrops fetalis [62].
The distribution of NT-proBNP levels in the umbilical cord blood of neonates with cardiac malformations according to the type. Abbreviations: HLHS, hypoplastic left heart syndrome; NT-proBNP, N-terminal pro-brain natriuretic peptide; RVOTO, right ventricular outflow tract obstruction; TOF, tetralogy of Fallot. Adapted from [61] with permission of Springer International Publishing AG.
The only one study reported 97.5th percentile upper reference limit of NT‐proBNP and TnT from healthy neonates, according to the CLSI guideline [21, 63]. In uterus, hemodynamics between placenta and fetal heart can vary with gestational age [64, 65], and reference intervals for cardiac biomarkers in neonates could be different from those in adults. Therefore, establishment of reference intervals is necessary to use cardiac biomarkers in neonates. Table 3 showed the comparison of sST2, NT‐proBNP, high sensitive TnI, and high sensitive TnT in UCB and adults. For these differences between laboratory tests results in UCB and adults, clinical laboratories should establish or verify reference intervals for cardiac biomarkers in UCB. Kim H et al. [66] reported that levels of sST2, NT-proBNP, and high sensitive TnT in UCB were significantly higher than those in adults.
97.5th percentile upper reference limit in UCB from healthy, full-term neonates (90% CI) | Medical decision point for adults (reference) | |
---|---|---|
sST2 (ng/mL) | 59.9 (52.7–62.2) | 35 [76] |
NT‐proBNP (pg/mL) | 1415.3 (1070.0–2198.0) | 300 [77], 125 [78] |
hs‐TnI (pg/mL) | 27.8 (21.v1–30.4) | 26.2 [79] |
hs‐TnT (pg/mL) | 86.5 (68.0–99.0) | 14 [80] |
Comparison of sST2, NT-proBNP, high sensitive TnI, and high sensitive TnT in UCB and adults. Adapted from [66] with permission of Walter de Gruyter GmbH.
sST2, soluble suppression of tumorigenicity 2; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; hs‐TnI, high sensitive troponin I; hs‐TnT, high sensitive troponin T; UCB, umbilical cord blood.
Current agricultural and agro-industrial systems apply the linear mode of production and, therefore, the majority of today agricultural and agro-industrial production and consumption systems are unsustainable. In other words, current agricultural and agro-industrial systems are economically, environmentally, and socially not sustainable. Precisely, the problems associated with nowadays agricultural, and agro-industries are (1) inefficient use of resources, (2) inefficient use of energy, (3) high production costs, (4) high environmental risks, and (5) massive wealth gap between the poor and the rich. Therefore, sustainability is a key issue in this context, where sustainable development encompasses the integration of social and environmental issues with economic development to convene the pressing needs of the population at present without undercutting the requirements of future generations. One key issue is to mimic the sustainable models provided by natural ecosystems. Precisely, turning the linear mode of production (linear economy) into the cyclic mode of production (circular economy). The current farming and agro-industrial processes have two main problems, which are the inefficient use of energy and wastes are not utilized within the production processes, which leads to the degradation of the surrounding environment. In contrast, natural ecosystem -which should be mimicked- allows the efficient use of energy, and all wastes are bioremediated and utilized by the system. Hence, the current farming and agro-industrial processes (linear) should be amended to mimic the natural ecosystem (circular), where this leads to the concept of industrial ecology, which fills the gap between the farming and agro-industrial processes on the one hand, and the ecologically sustainable natural system on the other hand.
According to the EU, “the bioeconomy encompasses the production of renewable biological resources and the conversion of these resources and waste streams into value-added products, such as food, feed, bio-based products, and bioenergy” [1]. Furthermore, “the transition to a more circular economy, where the value of products, materials, and resources is maintained in the economy for as long as possible, and the generation of waste minimized, is an essential contribution to the EU’s efforts to develop a sustainable, low carbon, resource-efficient, and competitive economy. Such transition is the opportunity to transform the economy and generate new and sustainable competitive advantages” [2]. Consequently, the bioeconomy is broader and deeper than a circular economy. On the other hand, biomass is defined as “the biodegradable fraction of products, waste, and residues from biological origin from agriculture (including vegetal and animal substances), forestry and related industries including fisheries and aquaculture, as well as the biodegradable fraction of industrial and municipal waste” [3]. In other words, biomass types are agricultural biomass (crops residues and animal wastes), fisheries biomass, algae biomass, and forest biomass.
Circular bio-based economy aims at reaching a net zero-carbon community by creating sustainable technologies and efficient resource use approaches to substitute the fossil-based economy. The circular bioeconomy primarily depends on biomass as a building block, while social, economic, and environmental are the principal factors. The technologies that are projected to be industrialized under circular bioeconomy must guarantee that the value of product carbon is preserved to decrease the wastewater production, greenhouse gas (GHG) emissions, and impairment to the ecosystems. In the context of circular bioeconomy growth, the biomass production, process advancements, and reuse approaches ought to be well defined to meet the global supply chain and demand. This urges conducting techno-economic assessment (TEA) and life cycle analysis (LCA) of every product and process.
Bioproducts or bio-based products are biomaterials, biochemicals, and bioenergy derived from renewable biological resources. The biological resources include agriculture, forestry, and biologically derived waste. One of the renewable bioresources is lignocellulose. Cellulose-based materials and lignocellulosic tissues are biologically derived natural resources.
Conventional bioproducts and emerging bioproducts are two broad categories used to categorize bioproducts. Examples of conventional bioproducts include building materials, pulp and paper, and forest products. Examples of emerging bioproducts include biofuels, bioenergy, starch-based, and cellulose-based ethanol or bioethanol, bio-based adhesives, biochemicals, bioplastics, etc. Bioproducts derived from bioresources can replace much of the fuels, chemicals, plastics, etc. that are currently derived from petroleum. As a result, the emerging bioproducts are environmentally friendly products and independent of fossil sources.
Bioprocessing and bioproducts production include the use of engineered microbiological systems for generating biofuels, bioelectricity, and new high-value bioproducts. Additionally, scientists are investigating the utilization of forestry products in untraditional applications, including industrial foams and flame-retardant materials. This needs to combine a conglomerate of mathematics, biology, and industrial design, and consists of numerous varieties of biotechnological processes, which pertain to the design, development, and implementation of processes, technologies for the sustainable manufacture of biomaterials, biochemicals, and bioenergy from renewable bioresources. Bioprocessing deals with the design and development of equipment and processes for making bioproducts such as food, feed, pharmaceuticals, nutraceuticals, biochemicals, biopolymers, and paper from biological materials (i.e., biomaterials). Practically, bioprocessing takes place in devices called bioreactors.
Bioreactors are categorized, based on the mode of operation, as a batch, semi-continuous or continuous bioreactors. Microorganisms growing in bioreactors may be submerged in a liquid medium or may be attached to the surface of a solid medium. The bioenvironmental conditions inside the bioreactor, such as temperature, nutrient concentrations, pH, and dissolved gases (especially oxygen for aerobic processes) affect the growth and productivity of the microorganisms.
Biological wastes i.e., biowastes, generated from agriculture, wastewater treatment, or industry are a largely untapped source for the production of value-added bioproducts or bioenergy. Their recovery utilizes biological and chemical processes that provide alternative sources for chemical feedstocks to produce different products e.g., bioplastics or other biopolymers, high-value biochemicals, protein for animal feed, and enzymes. For example, nutrients, cellulose, volatile fatty acids, extracellular polymeric substances, or proteins can be recovered from biowastes. Similarly, many opportunities exist for alternative energy products, e.g., bioethanol, biobutanol, biogas, biohydrogen, or bioelectricity. Resource biorecovery thus supports sustainability goals by reinjecting products into the circular economy.
For instance, the value-added bioprocessing of fish waste produces numerous bioproducts, which are: (1) pharmaceuticals such as proteins, jadomycin, collagen, lactic acid, glycerol, proteases, lipases, and collagenases; (2) nutraceuticals such as omega-3, amino acids, fish oil, fatty acids, carotenoids, isoflavones, and lutein; (3) chemicals such as 1,2-propanediol and 1,3-propanediol, dihydroxy-acetone, and methanol; (4) biofuels such as biodiesel, bioethanol, and biohydrogen; and (5) further products such as fish meal and fish silage. On the other hand, the value-added bioprocessing of slaughtering waste produces the same above-mentioned products except that the intermediate product, in this case, is the tallow compared to fish oil as an intermediate product in the bioprocessing of fish waste.
Furthermore, there are several potential uses of fish waste in the production of further pharmaceuticals such as chymotrypsin, pepsin, enzyme inhibitors, anticoagulants, insulin, nucleic acid, nucleotides, protamine, and proteolytic enzymes. Besides, several biochemicals can be produced such as bile salts, glue, gelatin, leather, and pearl essence.
The industrial ecology is the design of industrial infrastructures as a series of interlocking manufactured ecosystems in order to maximize the energy use efficiency, reduce the costs, reduce the environmental problems, identify new value-added products, and maximize the resources use efficiency, which leads to the sustainability. An important key issue is the interpretation of the insinuation of employing the ecological models to restore the agro-industrial systems, through applying the concepts of eco-design and eco-efficiency leading to a cleaner production allowing to reach a zero-waste and zero-emission system. This requires inevitably conducting environmental impact assessment and life cycle analysis of the agro-industrial processes and products. On the other hand, the aim of eco-efficiency is to boost the values of products by optimizing the utilization of resources and minimizing the negative environmental impacts by incorporating both efficiency and innovation into the industrial process without expensive pollution control techniques.
The cleaner production procedure is the first step in the implementation of the concept of industrial ecology. The procedure includes: (1) the examination of production systems in terms of the efficient use of natural resources and the efficient use of energy, and (2) the utilization of life cycle analyses method to evaluate the products and the agro-industrial processes in order to minimize waste and pollution as well as reduce costs and identify new prospects such as new products and employment opportunities.
Regarding the products, the procedure aims at reducing the negative impacts throughout the entire life cycle of the product from cradle to grave, i.e., from design to final disposal. Regarding the agro-industrial processes, cleaner production aims at (1) efficient use of raw materials, (2) efficient use of energy, and (3) reduction of emissions and wastes. An important key issue is to incorporate environmental concerns into designing processes and delivering the products.
The concept of integrated bioindustrial systems aims at (a) designing circular production and consumption systems leading to maximize the efficiencies of resources and energy uses and to allow the required energy and resources for forthcoming development, (2) forming a further ecologically sound and healthy environment through less waste is generated at each level of production and the conversion of waste into value-added products, and (3) emphasizing the socio-economic development through creating new employment opportunities and ground-breaking technologies and new products.
The biorefinery is the cornerstone of the integrated bioindustrial systems, where a biorefinery is a production plant that combines bioconversion processes biomass and devices such as bioreactors to generate biofuels, electrical energy, heat energy, and value-added biochemicals from biomass. The International Energy Agency, Bioenergy Task 42 on Biorefineries, has defined biorefining as the sustainable processing of biomass into a spectrum of bio-based products (food, feed, chemicals, materials) and bioenergy (biofuels, power, and/or heat). Considering that biomass is all organic matters -except fossil fuels- such as forest materials, agricultural crops residues, livestock manure, organic fraction of municipal solid wastes, fish processing wastes, and food processing wastes [4].
The concept of biorefinery has several objectives: (1) maximizing energy use efficiency, (2) maximizing resource use efficiency, (3) minimizing environmental problems, (4) creating new value-added products, and (5) creating new employment opportunities. However, there are some critical concerns such as the competing uses of materials, market demands, and production costs.
The biorefinery has several advantages: (1) through producing numerous products, a biorefinery takes advantage of the numerous components in biomass and their intermediates then intensifying the value derived from the biomass, and (2) through producing various low-volume, nevertheless high-value, chemical products such as nutraceuticals and pharmaceuticals and a low-value, nonetheless high-volume liquid transportation fuel such as biodiesel and bioethanol, (3) meanwhile generating electrical energy and heat, through combined heat and power (CHP) plant, and (4) creating new high value-added products maximizes the feasibility, where the high-volume fuel’s production meet the energy demands, and the electricity and heat production minimizes the energy costs and decreases the greenhouse gas (GHG) emissions.
However, the subsequent concerns should be considered: (1) risk of excessive consumption of edible crops, (2) risk of deterioration of organic and mineral content of soils, (3) risk of excessive utilization of chemical fertilizers and pesticides to advance the production levels, (4) risk of competition between food and biorefinery, and (5) risk of deforestation.
The following is an approach to transform the present agricultural systems (beef, dairy, and poultry farms as well as cereals and vegetable crops production) and agro-industrial systems (ethanol industry and fish industry) into integrated bioindustrial systems by altering their linear mode of production into a circular mode of production to create a coherent bioeconomy, where the bioeconomy includes the conversion of renewable bioresources and waste streams into value-added bioproducts, such as food, feed, pharmaceuticals, nutraceuticals, biomaterials, biochemicals, biofuels, and bioenergy.
Cereal and vegetable production encompasses the utilization of several inputs such as water, fertilizers, pesticides, seeds, and energy. The products are grains, fruits, and tuber/roots. However, the waste is agricultural crops residues (Figure 1). The concept of bioeconomy is to use the output i.e., waste, of an industry or production system as an input i.e., feedstock, in another new industry. Therefore, this waste is planned to be used as feedstock for a new forage industry, where the produced forages are used for feeding livestock in a new livestock production system that produces milk and meat. However, this industry generates animal waste i.e., manure, which is planned to be used as feedstock for a new biogas plant that produces biogas that fuels the cereal and vegetable crops production system. Besides, the generated sludge is used as a biofertilizer within the crops production system. Part of the generated sludge is used in a new compost facility and the produced compost is used within the crops production system as a biofertilizer. An important key issue is that 4 new industries were established and, therefore, 5 new products were produced, which are considered as economic development. It should be noticed that the core of all these newly planned industries and facilities, which were integrated with the crops production system, is creating new employment opportunities, which is considered as social development. Furthermore, these integrated bioindustrial systems have zero-waste, zero-emission, and efficient resources and energy use, which are considered as environmental development (Figure 2).
Linear mode of cereal and vegetable crops production (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, and the red circle designates the waste).
Cyclic mode of cereal and vegetable crops production through integrated bioindustrial systems (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, the red circle designates the waste, and the yellow wave designates the employment opportunity).
Beef and dairy production encompass the utilization of several inputs such as water, forages, and energy. The products are milk and meat. However, the wastes are slaughter waste, manure, and whey (Figure 3). The concept of bioeconomy is to use the output i.e., waste, of an industry or production system as an input i.e., feedstock, in another new industry. Therefore, the slaughter waste is used as feedstock in a biorefinery to produce biofuels, biochemicals, pharmaceuticals, and nutraceuticals. Additionally, manure and whey are planned to be used as feedstock for a new biogas plant, where the produced biogas is used for fueling the beef and dairy production system. The biogas plant generates sludge, which is used as biofertilizer for a new crops production system that produces grains and tuber/roots. Besides, the generated crop residues are used as feedstock for the forage industry, which produces forages for beef and dairy production. Part of the generated crops residues is used in a new compost facility and the produced compost is used in fertilizing the crops production as biofertilizer. An important key issue is that 5 new industries were established and, therefore, 9 new products were produced, which are considered as economic development. It should be noticed that the core of all these newly planned industries and facilities, which were integrated with the beef and dairy production system, is creating new employment opportunities, which is considered as social development. Furthermore, these integrated bioindustrial systems have zero-waste, zero-emission, and efficient resources and energy use, which are considered as environmental development (Figure 4).
Linear mode of beef and dairy production (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, and the red circle designates the waste).
Cyclic mode of beef and dairy production through integrated bioindustrial systems (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, the red circle designates the waste, and the yellow wave designates the employment opportunity).
The poultry industry encompasses the utilization of several inputs such as water, forages, and energy. The products are meat and eggs. However, the wastes are slaughter waste and manure (Figure 5). The concept of bioeconomy is to use the output i.e., waste, of an industry or production system as an input i.e., feedstock, in another new industry. Therefore, the slaughter waste is used as feedstock in a biorefinery to produce biofuels, biochemicals, pharmaceuticals, and nutraceuticals. Additionally, poultry manure is planned to be used as feedstock for a new biogas plant, where the produced biogas is used for fueling the poultry production system. The biogas plant generates sludge, which is used as biofertilizer for a new crops production system that produces grains and tuber/roots. Besides, the generated crop residues are used as feedstock for the forage industry which produces forages for the poultry farms. Part of the generated crops residues is used in a new compost facility and the produced compost is used in fertilizing the crops production as biofertilizer. An important key issue is that 5 new industries were established and, therefore, 9 new products were produced, which are considered as economic development. It should be noticed that the core of all these newly planned industries and facilities, which were integrated with the poultry production system, is creating new employment opportunities which is considered as social development. Furthermore, these integrated bioindustrial systems have zero-waste, zero-emission, and efficient resources and energy use, which are considered as environmental development (Figure 6).
Linear mode of poultry production (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, and the red circle designates the waste).
Cyclic mode of poultry production through integrated bioindustrial systems (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, the red circle designates the waste, and the yellow wave designates the employment opportunity).
The fish processing industry encompasses the utilization of several inputs such as water, feed, and energy. The product is canned fish. However, the wastes are a large amount of fish waste and a large amount of wastewater (Figure 7). The concept of bioeconomy is to use the output i.e., waste, of an industry or production system as an input i.e., feedstock, in another new industry. Therefore, a large amount of wastewater is planned to be used as feedstock for a new wastewater treatment plant, where the treated water is used as input water in the fish processing industry. Further, this plant generates sludge, which is planned to be used as feedstock for a new biogas plant that produces biogas that fuels the finish processing industry. Besides, the generated sludge is considered a new product as biofertilizer. On the other hand, the large amount of fish waste is used as feedstock for a new biorefinery that produces fish meal and fish silage, pharmaceuticals (proteins, jadomycin, collagen, lactic acid, glycerol, proteases, lipases, and collagenases), nutraceuticals (omega-3, amino acids, fish oil, fatty acids, carotenoids, isoflavones, and lutein), chemicals (1,2-propanediol and 1,3-propanediol, dihydroxy-acetone, and methanol), biofuels (biodiesel, bioethanol, and biohydrogen). An important key issue is that 6 new industries were established and, therefore, a multitude of new products were produced, which are considered as economic development. It should be noticed that the core of all these newly planned industries and facilities, which were integrated with the fish processing industry, is creating new employment opportunities, which is considered as social development. Furthermore, these integrated bioindustrial systems have zero-waste, zero-emission, and efficient resources and energy use, which are considered as environmental development (Figure 8).
Linear mode of fish industry (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, and the red circle designates the waste).
Cyclic mode of fish industry through integrated bioindustrial systems (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, the red circle designates the waste, and the yellow wave designates the employment opportunity).
The bioethanol industry encompasses the utilization of inputs such as energy and raw cellulosic materials. The product is bioethanol. However, the waste is broth (Figure 9). The concept of bioeconomy is to use the output i.e., waste, of an industry or production system as an input i.e., feedstock, in another new industry. Therefore, this waste is planned to be used as feedstock for a new processing industry that produces wastewater and biofertilizer, where these products are used in a new hydroponics system that produces biowastes (crops residues). These wastes i.e., crop residues, are planned to be used as feedstock for a new forage industry that produces forages for a new livestock production system. However, this industry generates animal waste i.e., manure, which is planned to be as feedstock for a new biogas plant, which produces biogas that fuels the bioethanol industry. Besides, the generated sludge is used as biofertilizer for a new crops production system. Part of the generated sludge is used in a new compost facility and the produced compost is used within the crops production system as biofertilizer. The produced crops residues from the new crops production system as feedstock in a new compost industry, which produces a biofertilizer. An important key issue is that 6 new industries were established and, therefore, 7 new products were produced which are considered as economic development. It should be noticed that the core of all these newly planned industries and facilities, which were integrated with the bioethanol industry, is creating new employment opportunities, which is considered as social development. Furthermore, these integrated bioindustrial systems have zero-waste, zero-emission, and efficient resources and energy use, which are considered as environmental development (Figure 10).
Linear mode of bioethanol industry (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, and the red circle designates the waste).
Cyclic mode of bioethanol industry through integrated bioindustrial systems (the orange oval designates the input, the blue rectangle designates the industry, the green hexagon designates the product, the red circle designates the waste, and the yellow wave designates the employment).
Digitalization is essential to the advancement of the bioeconomy. Digitalization is promoting intelligibility throughout the value chains and facilitates to scrutinize the conformity with afforded standards. Digitalization modifies the route for expanding traditional bioeconomy and is converting the bioeconomy into a progressively multi and interdisciplinary proficient sector.
The digital revolution in the bioeconomy has 3 unique aspects: (1) the utilization of digital tools as a tool for monitoring. For instance, real-time monitoring of farming operations such as crops, and livestock can provide timely and feasibly added value. Likewise, in forestry, monitoring provides added value by processing data, optimizing the conservation and use of forest products, (2) data aid the development of value chains in terms of reusing, recycling, and repairing. Digitalization provides data analysis for biorefineries or bioindustry can assist in identifying new products evolving from what was formerly considered as biowaste, and (3) data-driven at its core, biosciences are growing precipitously owing to the expanding repository of information. Its application can be observed through a wide range of products and services such as the usage of genomes for therapeutics, personalized medicine, and pharmaceuticals. It can be noticed as well in the advancement of biochemicals as alternatives for petrochemicals.
Digital tools offer a variety of prospects within the traditional bioeconomy sectors such as farming, fisheries, and forestry. For farmers, the ability to track and monitor their livestock and crops boosts daily operations and grants for accurate development. There are also prospects for improved precision, as data is pooled promptly throughout the value chain from forage to dairies, slaughterhouses, products manufacturing, marketing, and consumption. Within the forestry industry, digital tools can be used for monitoring, forecasting, and management of forests.
Digitalization is encouraging practices innovation by boosting both supply and value chains in the circular bio-based economy. Thus, digitalization is able to play a role as a facilitator of circular bioeconomy procedures by for instance altering business patterns. Manipulating data to detect gaps for improving manufacture, or even to pinpoint how to help obtain value from both current production lines and bio-based waste streams are components of this development. At this point, streams of the circular bio-based economy, for instance, biowaste streams, are employed in different approaches since the data-driven procedures are strengthening the bioeconomy.
Digitalization is a component of the circular bioeconomy, where the bioindustrial systems are aiming at applying the circular economy standards that broaden the lifecycle of biowaste by recycling them as feedstock for bioenergy generation. Digitalization, smart algorithms, and advanced computer modeling guarantee resource boosting in the bioindustrial systems, raise the value of green production and are a factor in energy trade-off. Applications include open innovation platforms providing data access, which is open for research and development (R&D) as well as business. Digitalization can be used to create higher-value products in the circular bio-based economy. Digital tools can be implemented for making new value-added bioproducts. For instance, the production of novel and high-value bioproducts using existing bioresources.
Big data is cornerstone in developing biosciences. In the health sector, for instance, big data is accelerating encouraging results in biomedical research. At this point, the quick leap of data-driven analysis is anticipated to reach a higher level of personalized medicine and pharmaceuticals. High levels of digitalization such as blockchain and artificial intelligence coupled with its application in, for instance, agriculture, aquaculture, and forestry, brand-new bioproducts, and recycling of by-products are projected to occur. The intersecting role of data for R&D as well as an invention in bioeconomy is applied in contemporary waste management such as the use of bacteria in biowaste degradation.
Data analysis is crucial for a profitable green transition. Numerous biorefineries implement data in fostering the applications of biosciences in utilizing, for instance, forest by-products. Biomaterials such as lignin were found to be valuable feedstock in the production of food, feed, and adhesives. Technologies such as pyrolysis use biological but inedible feedstock and produce liquid bio-oils. The bio-oil is consistent with the current fossil oil infrastructure, and thus fills one of the gaps arising between the bio-based economy and the petroleum-based economy. The rapid leap of data analysis is able to accelerate finding solutions for global challenges.
A digital transformation is in progress in the circular bio-based economy. Guaranteeing that rural communities realize the profits of this transformation necessitates a re-outlining of the discussion to emphasize not only the digitalization itself but the growth potential it offers. This prospective is comprehensive and involves the formation of innovative bioproducts, services, and bioindustries. While based on rural resources, these opportunities necessitate additional collaboration that reinforces rural–urban relationships. The digital revolution of the circular bio-based economy likewise retains the capability to carry out businesses in conventional circular bio-based economy sectors attracting a wider cross-section of communities. This leads to create new employment opportunities for rural communities.
Generally, the applications of digital tools include prototyping electronic boards, internet of things (IoT) platforms, software, and cellphone applications to control the operation of the bioproducts production systems as well as compute the input materials and energy on the one hand and the output materials and energy on the other hand. Similar applications include livestock farming, for example detecting the activity and health of the animals and informing the animal owner. Further applications include operating the cooling/heating systems based on detected indoor conditions in greenhouses and livestock barns. Another application is in precision farming to control the farming operations conducted by agricultural machinery connected to satellites. Further application is that digital tools can control the interoperability of agricultural systems e.g., control the soil-based sensors to be consistent with the tractor. Additionally, the role of mechatronics is highly foreseen in these applications. Finally, a further application is the use of QR-codes (Quick Response code) to boost comprehensibility across the value chain. For instance, QR-codes are used to track livestock, allowing consumers to trace the food they consume from its source through the route to the retailer. Several applications in this context were developed as cell phone applications [5] and desktop software [6, 7, 8, 9].
Nanotechnology and laser radiation have been implemented in the production process of several bioproducts [10, 11, 12, 13, 14, 15, 16]. Besides, the implementation of life cycle analysis (LCA) and environmental impact assessment (EIA) methodologies are of high importance to analyze the life cycle of bioproducts and to determine the environmental impact of the production processes [17, 18, 19, 20, 21]. A key issue is to conduct a techno-economic assessment (TEA) of the used technologies in the production process [22].
This study provides an approach to convert the present agricultural systems (beef, dairy, and poultry farms as well as cereals and vegetable crops production) and agro-industrial systems (ethanol industry and fish industry) into integrated bioindustrial systems and biorefineries through amending their linear mode of production into a circular mode of production to develop a sustainable bioeconomy. This development includes the bioconversion of biowaste streams from the existing agricultural and agro-industrial systems into value-added bioproducts, such as food, feed, pharmaceuticals, nutraceuticals, biomaterials, biochemicals, biofuels, and bioenergy where these novel bioproducts are considered as economic development. Whereas the core of the planned bioindustries is creating new employment opportunities, which is considered as social development. Furthermore, these integrated bioindustrial systems have zero-waste, zero-emission, and efficient resources and energy use, which are considered as environmental development. An important key issue is that digitalization guarantees resource boosting in the bioindustrial systems, where applications include the development of electronic boards, internet of things (IoT) platforms, software, and cellphone applications for monitoring and controlling the operations, computing input and output materials, and energy, and fostering comprehensibility across the value chain. Figure 11 summarizes the fields of science related to bioeconomy.
The fields of science related to bioeconomy.
Open Access publishing helps remove barriers and allows everyone to access valuable information, but article and book processing charges also exclude talented authors and editors who can’t afford to pay. The goal of our Women in Science program is to charge zero APCs, so none of our authors or editors have to pay for publication.
",metaTitle:"What Does It Cost?",metaDescription:"Open Access publishing helps remove barriers and allows everyone to access valuable information, but article and book processing charges also exclude talented authors and editors who can’t afford to pay. The goal of our Women in Science program is to charge zero APCs, so none of our authors or editors have to pay for publication.",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"We are currently in the process of collecting sponsorship. If you have any ideas or would like to help sponsor this ambitious program, we’d love to hear from you. Contact us at info@intechopen.com.
\\n\\nAll of our IntechOpen sponsors are in good company! The research in past IntechOpen books and chapters have been funded by:
\\n\\nWe are currently in the process of collecting sponsorship. If you have any ideas or would like to help sponsor this ambitious program, we’d love to hear from you. Contact us at info@intechopen.com.
\n\nAll of our IntechOpen sponsors are in good company! The research in past IntechOpen books and chapters have been funded by:
\n\n\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. Topics will include asset liability management, financial consequences of the financial crisis and covid-19, financial accounting, mergers and acquisitions, management accounting, SMEs, financial markets, corporate finance and governance, managerial technology and innovation, resource management and sustainable development, social entrepreneurship, corporate responsibility, ethics and accountability, microeconomics, labour economics, macroeconomics, public economics, financial economics, econometrics, direct marketing, creative marketing, internet marketing, market planning and forecasting, brand management, market segmentation and targeting and other topics under business and management. This book series will focus on various aspects of business and management whose in-depth understanding is critical for business and company management to function effectively during this uncertain time of financial crisis, Covid-19 pandemic, and military activity in Europe.
",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"May 11th, 2022",hasOnlineFirst:!1,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. He has published more than 400 works in his academic career and visited twenty-two universities worldwide as a visiting professor. Dr. Bobek is a member of the editorial boards of six international journals and a member of the Strategic Council of the Minister of Foreign Affairs of the Republic of Slovenia. He has a long history in academia, consulting, and entrepreneurship. His own consulting firm, Palemid, has managed twenty significant projects, such as Cooperation Program Interreg V-A (Slovenia-Austria) and Capacity Building for the Serbian Chamber of Enforcement Agents. He has also participated in many international projects in Italy, Germany, Great Britain, the United States, Spain, Turkey, France, Romania, Croatia, Montenegro, Malaysia, and China. Dr. Bobek is also a co-founder of the Academy of Regional Management in Slovenia.",institutionString:"Universities of Applied Sciences FH Joanneum, Austria",institution:null},editorTwo:{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",slug:"tatjana-horvat",fullName:"Tatjana Horvat",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hXb0hQAC/Profile_Picture_1642419002203",biography:"Tatjana Horvat works as a professor for accountant and auditing at the University of Primorska, Slovenia. She is a Certified State Internal Auditor (licensed by Ministry of Finance RS) and Certified Internal Auditor for Business Sector and Certified accountant (licensed by Slovenian Institute of Auditors). At the Ministry of Justice of Slovenia, she is a member of examination boards for court expert candidates and judicial appraisers in the following areas: economy/finance, valuation of companies, banking, and forensic investigation of economic operations/accounting. At the leading business newspaper Finance in Slovenia (Swedish ownership), she is the editor and head of the area for business, finance, tax-related articles, and educational programs.",institutionString:null,institution:{name:"University of Primorska",institutionURL:null,country:{name:"Slovenia"}}},editorThree:null},{id:"87",title:"Economics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/87.jpg",isOpenForSubmission:!0,editor:{id:"327730",title:"Prof.",name:"Jaime",middleName:null,surname:"Ortiz",slug:"jaime-ortiz",fullName:"Jaime Ortiz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002zaOKZQA2/Profile_Picture_1642145584421",biography:"Dr. Jaime Ortiz holds degrees from Chile, the Netherlands, and the United States. He has held tenured faculty, distinguished professorship, and executive leadership appointments in several universities around the world. Dr. Ortiz has previously worked for international organizations and non-government entities in economic and business matters, and he has university-wide globalization engagement in more than thirty-six countries. He has advised, among others, the United Nations Development Program, Inter-American Development Bank, Organization of American States, Pre-investment Organization of Latin America and the Caribbean, Technical Cooperation of the Suisse Government, and the World Bank. Dr. Ortiz is the author, co-author, or editor of books, book chapters, textbooks, research monographs and technical reports, and refereed journal articles. He is listed in Who’s Who in the World, Who’s Who in America, Who’s Who in Finance and Business, Who’s Who in Business Higher Education, Who’s Who in American Education, and Who’s Who Directory of Economists. Dr. Ortiz has been a Fulbright Scholar and an MSI Leadership Fellow with the W.K. Kellogg Foundation. His teaching interests revolve around global economies and markets while his research focuses on topics related to development and growth, global business decisions, and the economics of technical innovation.",institutionString:null,institution:{name:"University of Houston",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},{id:"88",title:"Marketing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/88.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:null,institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11675",title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",hash:"e1d9662c334dd78ab35bfb57c3bf106e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 19th 2022",isOpenForSubmission:!0,editors:[{id:"281317",title:"Dr.",name:"Fabio",surname:"Iannotti",slug:"fabio-iannotti",fullName:"Fabio Iannotti"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11677",title:"New Insights in Mammalian Endocrinology",coverURL:"https://cdn.intechopen.com/books/images_new/11677.jpg",hash:"c59dd0f87bbf829ca091c485f4cc4e68",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"321396",title:"Prof.",name:"Muhammad Subhan",surname:"Qureshi",slug:"muhammad-subhan-qureshi",fullName:"Muhammad Subhan Qureshi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11676",title:"Recent Advances in Homeostasis",coverURL:"https://cdn.intechopen.com/books/images_new/11676.jpg",hash:"63eb775115bf2d6d88530b234a1cc4c2",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 10th 2022",isOpenForSubmission:!0,editors:[{id:"203015",title:"Dr.",name:"Gaffar",surname:"Zaman",slug:"gaffar-zaman",fullName:"Gaffar Zaman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:48,paginationItems:[{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. Alhazzaa, Thomas Heinbockel and Antonei B. Csoka",slug:"diabetes-and-epigenetics",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81580",title:"Graft-Versus-Host Disease: Pathogenesis and Treatment",doi:"10.5772/intechopen.104450",signatures:"Shin Mukai",slug:"graft-versus-host-disease-pathogenesis-and-treatment",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81533",title:"Prenylation of Natural Products: An Overview",doi:"10.5772/intechopen.104636",signatures:"Kantharaju Kamanna and Aravind Kamath",slug:"prenylation-of-natural-products-an-overview",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kantharaju",surname:"Kamanna"}],book:{title:"Modifications of Biomolecules",coverURL:"https://cdn.intechopen.com/books/images_new/11098.jpg",subseries:null}},{id:"81067",title:"Encapsulation of Essential Oils and Their Use in Food Applications",doi:"10.5772/intechopen.103147",signatures:"Hamdy A. Shaaban and Amr Farouk",slug:"encapsulation-of-essential-oils-and-their-use-in-food-applications",totalDownloads:46,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"81099",title:"SK Channels and Heart Disease",doi:"10.5772/intechopen.104115",signatures:"Katherine Zhong, Shawn Kant, Frank Sellke and Jun Feng",slug:"sk-channels-and-heart-disease",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81188",title:"Structure- and Design-Based Difficulties in Recombinant Protein Purification in Bacterial Expression",doi:"10.5772/intechopen.103958",signatures:"Kubra Acikalin Coskun, Nazlıcan Yurekli, Elif Cansu Abay, Merve Tutar, Mervenur Al and Yusuf Tutar",slug:"structure-and-design-based-difficulties-in-recombinant-protein-purification-in-bacterial-expression",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yusuf",surname:"Tutar"},{name:"Nazlican",surname:"Yurekli"},{name:"Merve",surname:"Tutar"},{name:"Mervenur",surname:"Al"},{name:"Elif Cansu",surname:"Abay"},{name:"Kubra",surname:"Acikalin Coskun"}],book:{title:"Protein Detection",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",subseries:{id:"18",title:"Proteomics"}}}]},subseriesFiltersForOFChapters:[{caption:"Proteomics",value:18,count:3,group:"subseries"},{caption:"Metabolism",value:17,count:8,group:"subseries"},{caption:"Cell and Molecular Biology",value:14,count:17,group:"subseries"},{caption:"Chemical Biology",value:15,count:19,group:"subseries"}],publishedBooks:{paginationCount:0,paginationItems:[]},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"19",type:"subseries",title:"Animal Science",keywords:"Animal Science, Animal Biology, Wildlife Species, Domesticated Animals",scope:"The Animal Science topic welcomes research on captive and wildlife species, including domesticated animals. The research resented can consist of primary studies on various animal biology fields such as genetics, nutrition, behavior, welfare, and animal production, to name a few. Reviews on specialized areas of animal science are also welcome.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11415,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null,series:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517"},editorialBoard:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",institutionString:null,institution:{name:"Universidade Paulista",institutionURL:null,country:{name:"Brazil"}}},{id:"191123",title:"Dr.",name:"Juan José",middleName:null,surname:"Valdez-Alarcón",slug:"juan-jose-valdez-alarcon",fullName:"Juan José Valdez-Alarcón",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBfcQAG/Profile_Picture_1631354558068",institutionString:"Universidad Michoacana de San Nicolás de Hidalgo",institution:{name:"Universidad Michoacana de San Nicolás de Hidalgo",institutionURL:null,country:{name:"Mexico"}}},{id:"161556",title:"Dr.",name:"Maria Dos Anjos",middleName:null,surname:"Pires",slug:"maria-dos-anjos-pires",fullName:"Maria Dos Anjos Pires",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS8q2QAC/Profile_Picture_1633432838418",institutionString:null,institution:{name:"University of Trás-os-Montes and Alto Douro",institutionURL:null,country:{name:"Portugal"}}},{id:"209839",title:"Dr.",name:"Marina",middleName:null,surname:"Spinu",slug:"marina-spinu",fullName:"Marina Spinu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLXpQAO/Profile_Picture_1630044895475",institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",institutionURL:null,country:{name:"Romania"}}},{id:"92185",title:"Dr.",name:"Sara",middleName:null,surname:"Savic",slug:"sara-savic",fullName:"Sara Savic",profilePictureURL:"https://mts.intechopen.com/storage/users/92185/images/system/92185.jfif",institutionString:'Scientific Veterinary Institute "Novi Sad"',institution:{name:'Scientific Veterinary Institute "Novi Sad"',institutionURL:null,country:{name:"Serbia"}}}]},onlineFirstChapters:{paginationCount:3,paginationItems:[{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81188",title:"Structure- and Design-Based Difficulties in Recombinant Protein Purification in Bacterial Expression",doi:"10.5772/intechopen.103958",signatures:"Kubra Acikalin Coskun, Nazlıcan Yurekli, Elif Cansu Abay, Merve Tutar, Mervenur Al and Yusuf Tutar",slug:"structure-and-design-based-difficulties-in-recombinant-protein-purification-in-bacterial-expression",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yusuf",surname:"Tutar"},{name:"Nazlican",surname:"Yurekli"},{name:"Merve",surname:"Tutar"},{name:"Mervenur",surname:"Al"},{name:"Elif Cansu",surname:"Abay"},{name:"Kubra",surname:"Acikalin Coskun"}],book:{title:"Protein Detection",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"79353",title:"Protein Detection in Clinical Diagnosis and Management of Prevalent Neurodegenerative Diseases and Metabolic Disorders",doi:"10.5772/intechopen.101051",signatures:"Ohanube A.K. Goodluck, Obeta M. Uchejeso and Ikeagwulonu R. Chinaza",slug:"protein-detection-in-clinical-diagnosis-and-management-of-prevalent-neurodegenerative-diseases-and-m",totalDownloads:88,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Protein Detection",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",subseries:{id:"18",title:"Proteomics"}}}]},publishedBooks:{paginationCount:7,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Ph.D.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:"Federal University of ABC",institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:null,institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:null,institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.jpg",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"onlineFirst.detail",path:"/online-first/80049",hash:"",query:{},params:{id:"80049"},fullPath:"/online-first/80049",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()