Abstract
Plants respond to various abiotic and biotic stress conditions through accumulation of phenolic compounds. The specificity of these phenolic compounds accumulation depends on the type of stress condition and the response of plant species. Light stress induces biosynthesis of phenolic acids and flavonoids in plants. Temperature stress initially induces biosynthesis of osmoprotective compounds and then later stimulates synthesis of antioxidant enzymes and antioxidant compounds such as flavonoids, tannins and phenolic acids in plant cells. Salinity causes oxidative stress in plants by inducing production of reactive oxygen species. To resist against oxidative stress plants produce polyphenols, flavonoids, anthocyanins, phenolic acids and phenolic terpenes. Plants biosynthesize phenols and flavonoids during heavy metal stress.to scavenge the harmful reactive oxygen species and to detoxify the hydrogen peroxide. Plants accumulate phenols at the infection sites to slow down the growth of microbial pathogens and restrict them at infected site. Plants also accumulates salicylic acid and H2O2 at the infection site to induce the systemic acquired resistance (SAR) against microbial pathogens. Plants accumulate phenolic compounds which act as inhibitor or toxicant to harmful nematodes, insects and herbivores. Hence, phenols regulate crucial physiological functions in plants to resist against different stress conditions.
Keywords
- plant defense
- salinity
- drought
- microbial pathogens
- insects
- herbivores
- phenols
- flavonoids
- tannins
- terpenes
1. Introduction
Plants have developed various metabolic pathways which respond to different abiotic and biotic stress conditions specifically through biosynthesis of secondary metabolites. These metabolic pathways are linked with the primary metabolic pathways which are the integral part of growth regulating programmes in plants. During stress, plants reduce their growth and divert the primary metabolism towards biosynthesis of secondary metabolites. It specifically controls the expression level of genes through ontogeny and circadian clock phenomenon which are transcription factors responsible for regulation of growth and accumulation of various secondary metabolites in plants [1, 2, 3, 4, 5, 6]. The transportation and accumulation of secondary metabolites regulates defense and development processes in plants based on the developmental stage, type of tissue or organ, and specific stress condition. Among various plant metabolites, phenolic compounds are the natural secondary metabolites that are biosynthesized in plants through metabolic pathways such as pentose phosphate, shikimate, and phenylpropanoid pathway [7, 8, 9]. These pathways are used by plants to produce either monomeric phenolic compounds such as flavanoids, phenolic acids and phenylpropanoids or polymeric phenolic compounds like tannins, lignins, lignans, and melanins. Phenolic compounds possess structural diversity due to their specific function in plant growth and defense mechanism. Some phenolic compounds are widely available in many plant species while others are specifically available only in certain plants species [10]. These phenolic compounds not only help in regulating various types of physiological functions in plants during growth and development but are also involved in plant defense mechanisms. They are known to have defensive function against abiotic and biotic stress conditions. Abiotic stress includes stress generated due to environmental changes such as high or low light and temperature, ultraviolet (UV) radiation, deficiency of nutrients, drought or flood like conditions. Biotic stress includes infection from microbial pathogen, attack by herbivorous organisms, increased production of oxidative species and free radicals in cells. The capability to synthesize specific phenolic compounds in response to biotic or abiotic stress is developed in plants through adaptive evolutionary phenomenon. Due to different environmental challenges plants have developed diversity in synthesizing various phenolic compounds [11].
For example, there are remarkable accumulation of flavanoids and isoflavones when plants experience low temperature stress, nutrients deficiency, exposure to UV radiation, microbial infection or injured through herbivores attack [12, 13, 14]. Anthocyanins accumulation was observed in flowers and fruits to attract pollinators for pollination. Anthocyanins also accumulate in young leaves to protect them from herbivorous insects and photodamage to regulate normal growth of plants [15]. Flavanoids are observed in guard cells of plants to protect tissue from UV radiation. They also accumulate to reduce the reactive oxidative stress generated through UV-B radiation [16]. Accumulation of phenols is observed in plants when plant experiences toxic metal stress from soil [17, 18]. Phenolic compounds help plant to develop resistance against microbial pathogens by inducing position explicit oversensitive response to protect spread of infection [8]. Proanthocyanidins, gallotannins and ellagitannins accumulation was observed in plants when infected with viruses, fungi or herbivores during early development stages of plant [8]. Secretion of t-cinnamic acid was observed from barley roots when it was infected by fungal pathogen fusarium [19]. Secretion of rosmarinic acid was observed in roots of
2. Plant defense against light stress
Plants accumulate phenolic acids and flavonoids in the vacuoles of mesophyll and epidermal cells during the light stress through photosynthetic apparatus and metabolism [22, 23, 24]. Falcone Ferreyra et al. [25] observed that when maize plants are exposed to UV-B radiation expression of genes P1, B and PL1 increases which induces biosynthesis of transcription regulators anthocyanin and 3-deoxy-flavanoid which in turn regulates the activity of protein ZmFLS1 for converting the dihydroflavonols, dihydroquercetin and dihydrokaempferol to flavonols, quercetin and kaempferol respectively. Radyukina et al. [26] observed the accumulation of flavonoids, and anthocyanins in plants exposed to light and salinity stress. They suggested that flavonoids protect plants from UV-B radiation and anthocyanins protect from salinity stress. Manukyan [27] observed high accumulation of total phenol in
3. Plant defense against temperature stress
During high and low temperature stress, photosynthesis metabolism is inhibited and production of reactive oxygen species is stimulated which in turn damages the cells [40, 41]. To combat with this stress plants accumulate osmoprotective compounds such as soluble sugars, proline and glycine betaine which provides protection from oxidative damage [42]. Plants also biosynthesize antioxidant enzymes and substances to defense against oxidative stress [43]. Plants accumulate antioxidant metabolites such as phenolics, terpenes or alkaloids during temperature stress and develop stress resistance ability [44, 45, 46, 47]. During temperature stress activity of enzyme phenylalanine ammonia lyase increases which results in accumulation of phenolic compounds in plant cells. Rivero et al. [48] has suggested that during heat and cold stress there is remarkable accumulation of soluble phenolics in watermelon and tomato. Kasuga et al. [49] suggested that cold induced phenols accumulation in plant cells decreases the freezing point, maintains water potential and protects from cell disruption. Weidner et al. [50] observed increased content of tannins and soluble phenols in roots of grapevine after cold treatment. Amarowicz et al. [51] observed increased concentration of gallic acid, ferulic acid and caffeic acid in grapevines during cold stress. Isshiki et al. [52] observed accumulation of farinose flavonoids on aerial part of primula during the freezing cold stress. Rana and Bhushan [53] have suggested that temperature stress induces biosynthesis of phenolic compounds in plants and provides tolerance against cold stress. Commisso et al. [54] suggested that phenolic compounds protect cytoskeleton of microfilaments from reactive oxygen species. Chalker-Scott and Fuchigami [55] suggested that cellular injury and stress tolerance capacity in plants is increased by accumulation of phenolic compounds and then its incorporation in to the cell wall of cells in the form of either suberin or lignin.
4. Plant defense against drought stress
During drought stress plants produce reactive oxygen species (hydrogen peroxide H2O2, singlet oxygen O, superoxide anion O2−, and hydroxyl radical OH) which may cause protein degradation, cell mortality, membrane damage, lipid peroxidation and deoxy ribose nucleic acid (DNA) damage [56, 57]. In order, to prevent this damage, plants have detoxification system to neutralize the deleterious effect of reactive oxygen species which is regulated either by enzymes (superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), peroxidase (POD)) or by antioxidant molecules (phenols, vitamin C, carotenoids, tocopherol and glutathione) [58]. In plants overproduction of reactive oxygen species during stress is balanced through production of phenolic compounds and flavonoids using phenylpropanoid pathway [59]. Akula and Ravishankar [60] observed accumulation of flavonoids in leaves of willow plant during drought stress. Similarly, Nakabayashi et al. [61] observed increase in accumulation of anthocyanin and flavonoids in leaves of
The biosynthesis and accumulation of phenolic compounds during drought stress is regulated by enzymes of phenylpropanoid pathway. Initially, phenylalanine ammonia lyase (PAL) diverts the central carbon flux of primary metabolism towards synthesis of phenolic compounds. Increase in PAL activity indicates beginning of plant antioxidant defense mechanism and is regulated by feedback inhibition process through increase in accumulation of its own product cinnamic acid [62]. The variations in the transcription level of genes encoding for phenylalanine ammonia lyase (PAL) regulates the activity of the enzyme and in turn specific phenolic compounds are synthesized in response to biotic or abiotic stress. Chalcone synthase is an enzyme which shows high activity during drought stress. It is a key enzyme in flavonoid synthesis pathway which acts on the CoA-ester of cinnamic acid to form chalcone. The chalcone is converted to flavanone by chalcone flavanone isomerase (CHI) enzyme through isomerization which is a precursor for synthesis of numerous flavonoid compounds [59]. Hura et al. [63] observed accumulation of ferrulic acid and high activity of PAL enzyme in leaves of maize under water stress conditions. Even Phimchan et al. [64] observed high PAL activity and ferrulic acid accumulation in fruits of capsicum during drought stress. Nakabayashi et al. [61] observed high activity of another enzyme chalcone synthase in response to drought stress in
5. Plant defense against salinity stress
Salinity stress induces production of reactive oxygen species in plants which in turn causes oxidative stress. To resist against oxidative stress plants produce antioxidative metabolites such as polyphenols, flavonoids, anthocyanins, proanthocyanidins, phenolic acids and phenolic terpenes which quench the singlet oxygen, neutralize or absorb free radicals, decompose peroxides [45, 46, 47]. Yang et al. [69] suggested that accumulation of specific phenolic compounds in plants during salinity stress also depends on the type of plant species. Parida et al. [70] suggested that there was significant increase in polyphenols content in plants of
Another mechanism acquired by plants to resist against salinity stress is through salicylic acid which is an endogenous growth regulator and signaling molecule. It is a phenolic phytohormone which controls stress by decreasing H2O2 level and reducing oxidative damage in plants [76]. It enhances growth, development and productivity in plants during stress conditions [77]. Many research studies have suggested the function of salicylic acid in increasing salinity tolerance in plants. Jini and Joseph and Khan et al. [78, 79] had suggested that salicylic acid strengthens the salinity tolerance in plants such as
6. Plant defense against heavy metals
Ciriakova [92] has suggested that plants take up heavy metals through their roots which get accumulated inside the cell wall by apoplastic system. These heavy metals cause harm to plants by hindering the biochemical metabolisms such as cell division and elongation, photosynthesis, nitrogen metabolism, respiration, mineral nutrient utilization and water transportation [92, 93]. They inactivate essential enzymes by binding to their active sites, induce biosynthesis of reactive oxygen species, and exchange metal ions from biomolecules [94]. Plants biosynthesize phenols and flavonoids to scavenge the harmful reactive oxygen species which donates their electron to peroxidase enzymes to detoxify hydrogen peroxide produced under heavy metal stress conditions [95]. Shemet and Fedenko [96] observed accumulation of phenolic compounds in roots of maize under cadmium stress. Ali et al. [97] observed high activity of enzymes responsible for biosynthesis of phenols and flavonoids in roots of
7. Plant defense against microbial pathogens
The plant defense mechanism occurs in two stages, in first response there is rapid accumulation of phenols at the infection site which slowdowns the growth of pathogen. In second response it biosynthesizes specific stress related substances (simple phenols, phenolic phytoalexins, hydroxycinnamic acids etc.) which restrict the pathogen at the infected site. The step by step process of plant defense mechanism includes host cell death, necrosis, accumulation of phenolic compounds, modification of cell wall through phenolic compounds deposition or development of barriers, and at last synthesis of specific toxic compounds to eliminate the pathogens [103]. Pathogenic microbes are recognized by plant cell membrane proteins which are known as pattern recognition receptors (PRRs). They recognize conserved pathogen associated molecular patterns (PAMP) of microorganisms and gives signal to synthesize specific phenolic compounds, through defense mechanism known as PAMP induced immunity [104, 105, 106, 107, 108, 109, 110]. Plants induce multicomponent defense response after pathogen attack which includes reprogramming of genetic resources, expression of large number of defense related genes, and encoding of enzymes that catalyze defense metabolites (phytoalexins). This physiological process is regulated by transcriptional factors responsible for accumulation of specific phytoalexins in plants. On the other hand, salicylic acid also plays crucial role in resisting pathogen attack in plants. During pathogenic infection there is remarkable accumulation of pathogenesis related (PR) protein at the location distant from the infection site. Simultaneously, there is accumulation of salicylic acid and H2O2 at the infection site to regulate the systemic acquired resistance (SAR) in plant. It is being observed that exogenous application of salicylic acid induces systemic acquired resistance (SAR) in plants and provides resistance against pathogens [10].
Plants possesses innate immunity against pathogenic bacterial species. They have developed metabolic mechanism to resist against pathogenic bacterial through accumulation of phenolic compounds. Postel and Kemmerling [111] suggested that plants recognize the bacterial pathogens through pathogen associated molecular patterns (PAMPs). Mikulic Petkovsek et al. [112] observed accumulation of hydroxycinnamic acid, gallic acid, quercetins and catechin in walnut husk plant infected by
Previous studies by various scientists have suggested that phenolic compounds eliminate fungal pathogens by altering the permeability of cell membrane, altering the integrity of cell wall, suppression of enzymes activity, formation of free radicals, inhibition of certain protein biosynthesis, damage of DNA and suppressing the expression of virulence genes [115, 116, 117, 118]. The mode of action of flavonoids against fungal pathogens include damage of cytoplasmic membrane, distraction of cell wall, induction of cell death process, inhibition of enzyme activities, chelating of metal ions, binding with extracellular or soluble proteins, inhibition of efflux pump activity [12]. Gallego-Giraldo et al. [119, 120] suggested that the suppression of liginin biosynthesis genes (HCT) leads to the accumulation of salicylic acid which in turn increases transcription level of some pathogenesis related genes to improve immunity of plants. Widodo et al. [121] suggested that coumarins inhibit growth of fungi by altering the thickness of mitochondrial matrix, inducing apoptosis or inducing cell wall perforation which leads to release of cytoplasm from cell. Rahman [122] observed accumulation of furanocoumarin in celery and parsnip roots after
Kumar and Pandey [134] suggested that Phenolic compounds suppress the viral infection in plants and represses the replication of viruses through mode of actions such as damage of protein, DNA or ribose nucleic acid (RNA), inhibition of viral enzyme activities. Zakaryan et al. [135] suggested that flavonoids suppresses the viral infection by distraction of viral RNA translation, inhibition of viral DNA replication, inhibition of viral protein synthesis, inhibition of transcription factors responsible for viral enzymes and genome synthesis and interfering with viral structural protein. Shokoohinia et al. [136] suggested that coumarins inhibit viral replication in cells by inhibition of enzymes such as protease, integrase and reverse transcriptase. Dunkić et al. [137] observed that the monoterpenes carvacrol and thymol present in essential oil of
8. Plant defense against insects, nematodes and herbivorous organisms
Plants have to face various pathogenic attacks in natural environment. To resist against these pathogens plants have adjusted their physiological metabolism and developed metabolic pathways which synthesize wide range of phenolic compounds. These phenolic compounds are used either to attract or repell different organism as per plants benefit. They protect plants by acting as inhibitors and toxicants against insects, nematodes and herbivorous animals which feeds on them [142, 143, 144, 145]. Maxwell et al. [146] suggested that phenolic pigment (gossypol) found in cotton plants has toxic effect on
9. Conclusions
Phenolic compounds regulate crucial physiological functions in plants to provide resistance against various biotic and abiotic stress conditions. To protect against UV radiation plants synthesize phenolic acids and flavonoids to scavenge the reactive oxygen species generated due to light stress. During temperature stress activity of phenylalanine ammonia lyase enzyme increases which results in accumulation of phenols in plants. The accumulation of phenols during drought stress is regulated by the activity of either phenylalanine ammonia lyase (PAL) or chalcone synthase. Phenylalanine ammonia lyase (PAL) activity accumulates phenolic acids which are used as precursors for biosynthesis of specific phenolic compounds. Chalcone synthase activity accumulates numerous flavonoid compounds in plants during water deficiency. During salinity stress plants accumulate polyphenols, flavonoids, anthocyanins, phenolic acids and terpenes to resist against the oxidative stress. Plants also accumulate salicylic acid during salinity stress to decrease the level of H2O2 and reduce the oxidative damage. Plants synthesize phenols and flavonoids to scavenge the reactive oxygen species produced during heavy metal stress. Plants accumulate phenolic compounds at infection site to reduce growth and penetration of microbial pathogens in other tissues and organs. It recognizes microbial pathogens and induces defense response at genetic level to biosynthesize defense metabolites. Plants also accumulates salicylic acid and H2O2 at infection site to regulate systemic acquired resistance. Plants accumulate phenolic compounds in organs which acts as inhibitors or toxicants for nematodes, insects and herbivores.
10. Future prospectives
The biosynthesis of phenolic compounds in plants during abiotic and biotic stress increases adaptation of plants in harsh environment. Hence, it is necessary to understand the molecular mechanism regulating biosynthesis and accumulation of specific phenolic compounds during particular stress condition. There should be genetic level studies on regulation of transcription factors responsible for biosynthesis of specific phenolic compounds during each stress. There should be progressive studies on interactive biology between phenolic compounds and salicylic acid to understand the crosstalk between them during salinity stress, oxidative damage and microbial pathogen attack.
Acknowledgments
Authors are whole heartedly thankful to Department of Biosciences, Saurashtra University for providing all the necessary facilities.
Conflict of interest
Authors declare that there is no conflict of interest.
Abbreviations
UV | ultra violet |
H2O2 | hydrogen peroxide |
ROS | reactive oxygen species |
SOD | superoxide dismutase |
APX | ascorbate peroxidase |
CAT | catalase |
POD | peroxidase |
PAL | phenylalanine ammonia lyase |
CHI | chalcone flavanone isomerase |
SA | salicylic acid |
PRRs | pattern recognition receptors |
PAMP | pathogen associated molecular patterns |
PR | pathogenesis related |
SAR | systemic acquired resistance |
DNA | deoxy ribose nucleic acid |
RNA | ribose nucleic acid |
References
- 1.
Ornston LN, Yeh WK. Origins of metabolic diversity: Evolutionary divergence by sequence repetition. Proceedings of the National Academy of Sciences of the United States of America. 1979; 76 (8):3996-4000 - 2.
Wink M. Biochemistry of Plant Secondary Metabolism. UK/Sheffield, Boca Raton: Sheffield Academic Press/CRC Press; 1999 - 3.
Lehfeldt C, Shirley AM, Meyer K, Ruegger MO, Cusumano JC, Viitanen PV, et al. Cloning of the SNG1 gene of Arabidopsis reveals a role for a serine carboxypeptidase-like protein as an acyltransferase in secondary metabolism. The Plant Cell. 2000; 12 (8):1295-1306 - 4.
Tauber E, Last KS, Olive PJ, Kyriacou CP. Clock gene evolution and functional divergence. Journal of Biological Rhythms. 2004; 19 (5):445-458 - 5.
Broun P. Transcriptional control of flavonoid biosynthesis: A complex network of conserved regulators involved in multiple aspects of differentiation in Arabidopsis. Current Opinion in Plant Biology. 2005; 8 (3):272-279 - 6.
do Nascimento NC, Fett-Neto AG. Plant secondary metabolism and challenges in modifying its operation: An overview. In: Fett-Neto A, editor. Plant Secondary Metabolism Engineering. Methods in Molecular Biology (Methods and Protocols). Vol. 643. Totowa, NJ: Humana Press; 2010. pp. 1-13. DOI: 10.1007/978-1-60761-723-5_1 - 7.
Balasundram N, Sundram K, Samman S. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chemistry. 2006; 99 (1):191-203. DOI: 10.1016/j.foodchem.2005.07.042 - 8.
Cheynier V, Comte G, Davies KM, Lattanzio V, Martens S. Plant phenolics: Recent advances on their biosynthesis, genetics, and ecophysiology. Plant Physiology and Biochemistry. 2013; 72 :1-20. DOI: 10.1016/j.plaphy.2013.05.009 - 9.
Heleno SA, Martins A, Queiroz MJ, Ferreira IC. Bioactivity of phenolic acids: Metabolites versus parent compounds: A review. Food Chemistry. 2015; 173 :501-513. DOI: 10.1016/j.foodchem.2014.10.057 - 10.
Kumar S, Abedin MM, Singh AK, Das S. Role of phenolic compounds in plant-defensive mechanisms. In: Plant Phenolics in Sustainable Agriculture. Singapore: Springer; 2020. pp. 517-532. DOI: 10.1007/978-981-15-4890-1_22 - 11.
Caputi L, Malnoy M, Goremykin V, Nikiforova S, Martens S. A genome-wide phylogenetic reconstruction of family 1 UDP-glycosyltransferases revealed the expansion of the family during the adaptation of plants to life on land. The Plant Journal. 2012; 69 (6):1030-1042 - 12.
Mierziak J, Kostyn K, Kulma A. Flavonoids as important molecules of plant interactions with the environment. Molecules. 2014; 19 (10):16240-16265 - 13.
Schulz E, Tohge T, Zuther E, Fernie AR, Hincha DK. Flavonoids are determinants of freezing tolerance and cold acclimation in Arabidopsis thaliana. Scientific Reports. 2016; 6 (1):1. DOI: 10.1038/srep34027 - 14.
Rodríguez-Calzada T, Qian M, Strid Å, Neugart S, Schreiner M, Torres-Pacheco I, et al. Effect of UV-B radiation on morphology, phenolic compound production, gene expression, and subsequent drought stress responses in chili pepper ( Capsicum annuum L.). Plant Physiology and Biochemistry. 2019;134 :94-102. DOI: 10.1016/j.plaphy.2018.06.025 - 15.
Karageorgou P, Manetas Y. The importance of being red when young: Anthocyanins and the protection of young leaves of Quercus coccifera from insect herbivory and excess light. Tree Physiology. 2006;26 (5):613-621. DOI: 10.1093/treephys/26.5.613 - 16.
Agati G, Tattini M. Multiple functional roles of flavonoids in photoprotection. New Phytologist. 2010; 186 (4):786-793 - 17.
Michalak A. Phenolic compounds and their antioxidant activity in plants growing under heavy metal stress. Polish Journal of Environmental Studies. 2006; 15 (4):523-530. DOI: 10.1016/j.fitote.2011.01.018 - 18.
Mandal SM, Chakraborty D, Dey S. Phenolic acids act as signaling molecules in plant-microbe symbioses. Plant Signaling and Behavior. 2010; 5 (4):359-368 - 19.
Lanoue A, Burlat V, Schurr U, Röse US. Induced root-secreted phenolic compounds as a belowground plant defense. Plant Signaling and Behavior. 2010; 5 (8):1037-1038. DOI: 10.4161/psb.5.8. 12337 - 20.
Bais HP, Walker TS, Stermitz FR, Hufbauer RA, Vivanco JM. Enantiomeric-dependent phytotoxic and antimicrobial activity of (±)-catechin. A rhizosecreted racemic mixture from spotted knapweed. Plant Physiology. 2002; 128 (4):1173-1179 - 21.
Wurst S, Wagenaar R, Biere A, Van der Putten WH. Microorganisms and nematodes increase levels of secondary metabolites in roots and root exudates of Plantago lanceolata . Plant and Soil. 2010;329 (1):117-126. DOI: 10.1007/s11104-009-0139-2 - 22.
Szymańska R, Ślesak I, Orzechowska A, Kruk J. Physiological and biochemical responses to high light and temperature stress in plants. Environmental and Experimental Botany. 2017; 139 :165-177. DOI: 10.1016/j.envexpbot.2017.05.002 - 23.
Tattini M, Galardi C, Pinelli P, Massai R, Remorini D, Agati G. Differential accumulation of flavonoids and hydroxycinnamates in leaves of Ligustrum vulgare under excess light and drought stress. New Phytologist. 2004;163 (3):547-561. DOI: 10.1111/j.1469-8137.2004.01126.x - 24.
Conéjéro G, Noirot M, Talamond P, Verdeil JL. Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees. Frontiers in Plant Science. 2014; 5 :39. DOI: 10.3389/fpls.2014.00039 - 25.
Falcone Ferreyra ML, Rius S, Emiliani J, Pourcel L, Feller A, Morohashi K, et al. Cloning and characterization of a UV-B-inducible maize flavonol synthase. The Plant Journal. 2010; 62 (1):77-91. DOI: 10.1111/j.1365-313X.2010.04133.x - 26.
Radyukina NL, Toaima VI, Zaripova NR. The involvement of low-molecular antioxidants in cross-adaptation of medicine plants to successive action of UV-B radiation and salinity. Russian Journal of Plant Physiology. 2012; 59 (1):71-78. DOI: 10.1134/s1021443712010165 - 27.
Manukyan A. Effects of PAR and UV-B radiation on herbal yield, bioactive compounds and their antioxidant capacity of some medicinal plants under controlled environmental conditions. Photochemistry and Photobiology. 2013; 89 (2):406-414. DOI: 10.1111/j.1751-1097.2012.01242.x - 28.
Ma P, Liu J, Zhang C, Liang Z. Regulation of water-soluble phenolic acid biosynthesis in Salvia miltiorrhiza Bunge. Applied Biochemistry and Biotechnology. 2013;170 (6):1253-1262. DOI: 10.1007/s12010-013-0265-4 - 29.
Ghasemzadeh A, Jaafar HZ, Rahmat A. Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger ( Zingiber officinale Roscoe). Molecules. 2010;15 (6):4324-4333 - 30.
Jang HJ, Lee SJ, Kim CY, Hwang JT, Choi JH, Park JH, et al. Effect of sunlight radiation on the growth and chemical constituents of Salvia plebeia R. Br. Molecules. 2017;22 (8):1279. DOI: 10.3390/molecules22081279 - 31.
Csepregi K, Coffey A, Cunningham N, Prinsen E, Hideg É, Jansen MA. Developmental age and UV-B exposure co-determine antioxidant capacity and flavonol accumulation in Arabidopsis leaves. Environmental and Experimental Botany. 2017; 140 :19-25. DOI: 10.1016/j.envexpbot.2017.05.009 - 32.
León-Chan RG, López-Meyer M, Osuna-Enciso T, Sañudo-Barajas JA, Heredia JB, León-Félix J. Low temperature and ultraviolet-B radiation affect chlorophyll content and induce the accumulation of UV-B-absorbing and antioxidant compounds in bell pepper ( Capsicum annuum ) plants. Environmental and Experimental Botany. 2017;139 :143-151. DOI: 10.1016/j.envexpbot.2017.05.006 - 33.
Peng M, Shahzad R, Gul A, Subthain H, Shen S, Lei L, et al. Differentially evolved glucosyltransferases determine natural variation of rice flavone accumulation and UV-tolerance. Nature Communications. 2017; 8 (1):1-2. DOI: 10.1038/s41467-017-02168-x - 34.
Zhou Z, Schenke D, Miao Y, Cai D. Investigation of the crosstalk between the flg22 and the UV-B-induced flavonol pathway in Arabidopsis thaliana seedlings. Plant Cell Environment. 2017;40 (3):453-458. DOI: 10.1111/pce.12869 - 35.
Lobiuc A, Vasilache V, Oroian M, Stoleru T, Burducea M, Pintilie O, et al. Blue and red LED illumination improves growth and bioactive compounds contents in acyanic and cyanic Ocimum basilicum L. microgreens. Molecules. 2017;22 (12):2111. DOI: 10.3390/molecules22122111 - 36.
Chen GJ, Lee MS, Lin MK, Ko CY, Chang WT. Blue light decreases tanshinone IIA content in Salvia miltiorrhiza hairy roots via genes regulation. Journal of Photochemistry and Photobiology B: Biology. 2018;183 :164-171 - 37.
Taulavuori K, Pyysalo A, Taulavuori E, Julkunen-Tiitto R. Responses of phenolic acid and flavonoid synthesis to blue and blue-violet light depends on plant species. Environmental and Experimental Botany. 2018; 150 :183-187. DOI: 10.1016/j.envexpbot.2018.03.016 - 38.
Stagnari F, Di Mattia C, Galieni A, Santarelli V, D'Egidio S, Pagnani G, et al. Light quantity and quality supplies sharply affect growth, morphological, physiological and quality traits of basil. Industrial Crops and Products. 2018; 122 :277-289. DOI: 10.1016/j.indcrop.2018.05.073 - 39.
Nadeem M, Abbasi BH, Younas M, Ahmad W, Zahir A, Hano C. LED-enhanced biosynthesis of biologically active ingredients in callus cultures of Ocimum basilicum . Journal of Photochemistry and Photobiology B: Biology. 2019;190 :172-178. DOI: 10.1016/j.jphotobiol.2018.09.011 - 40.
Asada K. Production and scavenging of reactive oxygen species in chloroplasts and their functions. Plant Physiology. 2006; 141 (2):391-396 - 41.
Hasanuzzaman M, Nahar K, Alam M, Roychowdhury R, Fujita M. Physiological, biochemical, and molecular mechanisms of heat stress tolerance in plants. International Journal of Molecular Sciences. 2013; 14 (5):9643-9684 - 42.
Sakamoto A, Murata N. Genetic engineering of glycinebetaine synthesis in plants: Current status and implications for enhancement of stress tolerance. Journal of Experimental Botany. 2000; 51 (342):81-88 - 43.
Balla K, Bencze S, Janda T, Veisz O. Analysis of heat stress tolerance in winter wheat. Acta Agronomica Hungarica. 2009; 57 (4):437-444 - 44.
Hoque, Tahsina S, AAM Sohag, DJ Burritt, and MA Hossain. Salicylic acid-mediated salt stress tolerance in plants. In Plant Phenolics in Sustainable Agriculture. Singapore: Springer; 2020. pp. 1-38 - 45.
Oh MM, Carey EE, Rajashekar CB. Environmental stresses induce health-promoting phytochemicals in lettuce. Plant Physiology and Biochemistry. 2009; 47 (7):578-583 - 46.
Lo Piero AR, Puglisi I, Rapisarda P, Petrone G. Anthocyanins accumulation and related gene expression in red orange fruit induced by low temperature storage. Journal of Agricultural and Food Chemistry. 2005; 53 (23):9083-9088 - 47.
Christie PJ, Alfenito MR, Walbot V. Impact of low-temperature stress on general phenylpropanoid and anthocyanin pathways: Enhancement of transcript abundance and anthocyanin pigmentation in maize seedlings. Planta. 1994; 194 (4):541-549 - 48.
Rivero RM, Ruiz JM, Garcıa PC, Lopez-Lefebre LR, Sánchez E, Romero L. Resistance to cold and heat stress: Accumulation of phenolic compounds in tomato and watermelon plants. Plant Science. 2001; 160 (2):315-321 - 49.
Kasuga J, Hashidoko Y, Nishioka A, Yoshiba M, Arakawa K, Fujikawa S. Deep supercooling xylem parenchyma cells of katsura tree ( Cercidiphyllum japonicum ) contain flavonol glycosides exhibiting high anti-ice nucleation activity. Plant, Cell & Environment. 2008;31 (9):1335-1348 - 50.
Weidner S, Karolak M, Karamac M, Kosinska A, Amarowicz R. Phenolic compounds and properties of antioxidants in grapevine roots [ Vitis vinifera L.] under drought stress followed by recovery. Acta Societatis Botanicorum Poloniae. 2009;78 (2):97-103 - 51.
Amarowicz R, Weidner S, Wójtowicz I, Karmac M, Kosinska A, Rybarczyk A. Influence of low-temperature stress on changes in the composition of grapevine leaf phenolic compounds and their antioxidant properties. Functional Plant Science and Biotechnology. 2010; 4 :90-96 - 52.
Isshiki R, Galis I, Tanakamaru S. Farinose flavonoids are associated with high freezing tolerance in fairy primrose ( Primula malacoides ) plants. Journal of Integrative Plant Biology. 2014;56 (2):181-188 - 53.
Rana S, Bhushan S. Apple phenolics as nutraceuticals: Assessment, analysis and application. Journal of Food Science and Technology. 2016; 53 (4):1727-1738 - 54.
Commisso M, Toffali K, Strazzer P, Stocchero M, Ceoldo S, Baldan B, et al. Impact of phenylpropanoid compounds on heat stress tolerance in carrot cell cultures. Frontiers in Plant Science. 2016; 7 :1439 - 55.
Chalker-Scott L, Fuchigami LH. The role of phenolic compounds in plant stress responses. In: Low Temperature Stress Physiology in Crops. Boca Raton: CRC Press; 2018. pp. 67-80 - 56.
Zhang J, Kirkham MB. Drought-stress-induced changes in activities of superoxide dismutase, catalase, and peroxidase in wheat species. Plant & Cell Physiology. 1994; 35 (5):785-791 - 57.
Shao HB, Chu LY, Lu ZH, Kang CM. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. International Journal of Biological Sciences. 2008; 4 (1):8 - 58.
Ashraf MA, Riaz M, Arif MS, Rasheed R, Iqbal M, Hussain I, et al. The role of non-enzymatic antioxidants in improving abiotic stress tolerance in plants. In: Plant Tolerance to Environmental Stress: Role of Phytoprotectants. Boca Raton: CRC Press; 2019. pp. 129-144 - 59.
Kumar S, Bhushan B, Wakchaure GC, Meena KK, Kumar M, Meena NL, et al. Plant phenolics under water-deficit conditions: Biosynthesis, accumulation, and physiological roles in water stress alleviation. In: Plant Phenolics in Sustainable Agriculture. Singapore: Springer; 2020. pp. 451-465 - 60.
Akula R, Ravishankar GA. Influence of abiotic stress signals on secondary metabolites in plants. Plant Signaling & Behavior. 2011; 6 (11):1720-1731 - 61.
Nakabayashi R, Yonekura-Sakakibara K, Urano K, Suzuki M, Yamada Y, Nishizawa T, et al. Enhancement of oxidative and drought tolerance in Arabidopsis by over accumulation of antioxidant flavonoids. The Plant Journal. 2014; 77 (3):367-379 - 62.
Boudet A. Evolution and current status of research in phenolic compounds. Phytochemistry. 2007; 68 (22-24):2722-2735 - 63.
Hura T, Hura K, Grzesiak S. Contents of total phenolics and ferulic acid, and PAL activity during water potential changes in leaves of maize single-cross hybrids of different drought tolerance. Journal of Agronomy and Crop Science. 2008; 194 (2):104-112 - 64.
Phimchan P, Chanthai S, Bosland PW, Techawongstien S. Enzymatic changes in phenylalanine ammonia-lyase, cinnamic-4-hydroxylase, capsaicin synthase, and peroxidase activities in Capsicum under drought stress. Journal of Agricultural and Food Chemistry. 2014; 62 (29):7057-7062 - 65.
Gharibi S, Tabatabaei BES, Saeidi G, Goli SAH. Effect of drought stress on total phenolic, lipid peroxidation, and antioxidant activity of Achillea species. Applied Biochemistry and Biotechnology. 2016; 178 (4):796-809 - 66.
Siracusa L, Gresta F, Sperlinga E, Ruberto G. Effect of sowing time and soil water content on grain yield and phenolic profile of four buckwheat ( Fagopyrum esculentum Moench.) varieties in a Mediterranean environment. Journal of Food Composition and Analysis. 2017;62 :1-7 - 67.
Sarker U, Oba S. Drought stress enhances nutritional and bioactive compounds, phenolic acids and antioxidant capacity of Amaranthus leafy vegetable. BMC Plant Biology. 2018; 18 (1):258 - 68.
Brunetti C, Loreto F, Ferrini F, Gori A, Guidi L, Remorini D, et al. Metabolic plasticity in the hygrophyte Moringa oleifera exposed to water stress. Tree Physiology. 2018;38 (11):1640-1165 - 69.
Yang L, Wen K, Ruan X, Zhao Y, Wei F, Wang Q. Response of plant secondary metabolites to environmental factors. Molecules. 2018; 23 :276 - 70.
Parida AK, Das AB, Sanada Y, Mohanty P. Effects of salinity on biochemical components of the mangrove, Aegiceras corniculatum . Aquatic Botany. 2004;80 :77-87 - 71.
Ksouri R, Megdiche W, Debez A. Salinity effects on polyphenol content and antioxidant activities in leaves of the halophyte Cakile maritima . Plant Physiology and Biochemistry. 2007;45 :244-249 - 72.
Hanen F, Ksouri R, Megdiche W, Trabelsi N, Boulaaba M, Abdelly C. Effect of salinity on growth, leaf phenolic content and antioxidant scavenging activity in Cynara cardunculus L. In: Abdelli C, Öztürk M, Ashraf M, Grignon YC, editors. Biosaline Agriculture and High Salinity Tolerance. Basel: Birkhauser Verlag; 2008. pp. 335-343 - 73.
Lim JH, Park KJ, Kim BK, Jeong JW, Kim HJ. Effect of salinity stress on phenolic compounds and carotenoids in buckwheat ( Fagopyrum esculentum M.) sprout. Food Chemistry. 2012;135 :1065-1070 - 74.
Petridis A, Therios I, Samouris G, Tananaki C. Salinity-induced changes in phenolic compounds in leaves and roots of four olive cultivars ( Olea europaea L.) and their relationship to antioxidant activity. Environmental and Experimental Botany. 2012;79 :37-43 - 75.
Borgognone D, Cardarelli M, Rea E, Lucini L, Colla G. Salinity source-induced changes in yield, mineral composition, phenolic acids and flavonoids in leaves of artichoke and cardoon grown in floating system. Journal of the Science of Food and Agriculture. 2014; 94 :1231-1237 - 76.
Lee NY, Lee MJ, Kim YK, Park J, Park HK, Choi JS, et al. Effect of light emitting diode radiation on antioxidant activity of barley leaf. Journal of Korean Society for Applied Biological Chemistry. 2010; 53 :685-690 - 77.
Rajeshwari V, Bhuvaneshwari V. Salicylic acid induced salt stress tolerance in plants. International Journal of Plant Biology & Research. 2017; 5 :1067 - 78.
Jini D, Joseph B. Physiological mechanism of salicylic acid for alleviation of salt stress in rice. Rice Science. 2017; 24 :97-108 - 79.
Khan MIR, Fatma M, Per TS, Anjum NA, Khan NA. Salicylic acid-induced abiotic stress tolerance and underlying mechanisms in plants. Frontiers in Plant Science. 2015; 6 :462 - 80.
Jayakannan M, Bose J, Babourina O, Rengel Z, Shabala S. Salicylic acid improves salinity tolerance in Arabidopsis by restoring membrane potential and preventing salt-induced K+ loss via a GORK channel. Journal of Experimental Botany. 2013; 64 (8):2255-2268 - 81.
Borsani O, Valpuesta V, Botella MA. Evidence for a role of salicylic acid in the oxidative damage generated by NaCl and osmotic stress in Arabidopsis seedlings. Plant Physiology. 2001; 126 :1024-1030 - 82.
Cao Y, Zhang ZW, XueL W, Du JB, Shang J, Xu F, et al. Lack of salicylic acid in Arabidopsis protects plants against moderate salt stress. Zeitschrift für Naturforschung. 2009; C64 :231-238 - 83.
Asensi-Fabado M, Munné-Bosch S. The aba3-1 mutant of Arabidopsis thaliana withstands moderate doses of salt stress by modulating leaf growth and salicylic acid levels. Journal of Plant Growth Regulation. 2011;30 :456-466 - 84.
Miura K, Sato A, Ohta M, Furukawa J. Increased tolerance to salt stress in the phosphateaccumulating Arabidopsis mutants siz1 and pho2. Planta. 2011; 234 :1191-1199 - 85.
Hao L, Zhao Y, Jin D, Zhang L, Bi X, Chen H, et al. Salicylic acid-altering Arabidopsis mutants response to salt stress. Plant and Soil. 2012; 354 :81-95 - 86.
Ashraf M, Akram NA, Arteca RN, Foolad MR. The physiological, biochemical and molecular roles of brassinosteroids and salicylic acid in plant processes and salt tolerance. Critical Reviews in Plant Sciences. 2010; 29 :162-190 - 87.
Hayat Q, Hayat S, Irfan M, Ahmad A. Effect of exogenous salicylic acid under changing environment: A review. Environmental and Experimental Botany. 2010; 68 :14-25 - 88.
Palma F, López-Gómez M, Tejera NA, Lluch C. Salicylic acid improves the salinity tolerance of Medicago sativa in symbiosis withSinorhizobium meliloti by preventing nitrogen fixation inhibition. Plant Science. 2013;208 :75-82 - 89.
Khan MIR, Asgher M, Khan NA. Alleviation of salt-induced photosynthesis and growth inhibition by salicylic acid involves glycinebetaine and ethylene in mungbean ( Vigna radiata L.). Plant Physiology and Biochemistry. 2014;80 :67-74 - 90.
Lee SY, Damodaran PN, Roh KS. Influence of salicylic acid on rubisco and rubisco activase in tobacco plant grown under sodium chloride in vitro. Saudi Journal of Biological Sciences. 2014; 21 (5):417-426 - 91.
Ardebili NO, Saadatmand S, Niknam V, Khavari-Nejad RA. The alleviating effects of selenium and salicylic acid in salinity exposed soybean. Acta Physiologiae Plantarum. 2014; 36 (12):3199-3205 - 92.
Ciriakova A. Heavy metals in the vascular plants of Tatra Mountains. Oecologia Montana. 2009; 18 (1-2):23-26 - 93.
Sytar O, Kumar A, Latowski D, Kuczynska P, Strzałka K, Prasad MNV. Heavy metalinduced oxidative damage, defense reactions, and detoxification mechanisms in plants. Acta Physiologiae Plantarum. 2013; 35 (4):985-999 - 94.
Schützendübel A, Polle A. Plant responses to abiotic stresses: Heavy metal-induced oxidative stress and protection by mycorrhization. Journal of Experimental Botany. 2002; 53 :1351-1365 - 95.
Sakihama Y, Yamasaki H. Lipid peroxidation induced by phenolics in conjunction with aluminum ions. Biologia Plantarum. 2002; 45 (2):249-254 - 96.
Shemet SA, Fedenko VS. Accumulation of phenolic compounds in maize seedlings under toxic cadmium influence. Fiziologiia i biokhimiia kul'turnykh rastenii. 2005; 37 (6):505 - 97.
Ali MB, Singh N, Shohael AM, Hahn EJ, Paek KY. Phenolics metabolism and lignin synthesis in root suspension cultures of Panax ginseng in response to copper stress. Plant Science. 2006;171 (1):147-154 - 98.
Kováčik J, Klejdus B, Bačkor M, Repčák M. Phenylalanine ammonia-lyase activity and phenolic compounds accumulation in nitrogen-deficient Matricaria chamomilla leaf rosettes. Plant Science. 2007;172 (2):393-399 - 99.
Pawlak-Sprada S, Arasimowicz-Jelonek M, Podgórska M, Deckert J. Activation of phenylpropanoid pathway in legume plants exposed to heavy metals. Part I. Effects of cadmium and lead on phenylalanine ammonia-lyase gene expression, enzyme activity and lignin content. Acta Biochimica Polonica. 2011; 58 (2):211-216 - 100.
Márquez-García B, Fernandez-Recamales M, Cordoba F. Effects of cadmium on phenolic composition and antioxidant activities of Erica andevalensis . Environmental and Experimental Botany. 2012;75 (1):159-166 - 101.
Malčovská SM, Dučaiová Z, Maslaňáková I, Bačkor M. Effect of silicon on growth, photosynthesis, oxidative status and phenolic compounds of maize ( Zea mays L.) grown in cadmium excess. Water, Air, and Soil Pollution. 2014;225 (8):2056 - 102.
Kısa D, Elmastaş M, Öztürk L, Kayır Ö. Responses of the phenolic compounds of Zea mays under heavy metal stress. Applied Biological Chemistry. 2016;59 (6):813-820 - 103.
Nicholson RL, Hammerschmidt R. Phenolic compounds and their role in disease resistance. Annual Review of Phytopathology. 1992; 30 :369-389 - 104.
Bittel P, Robatzek S. Microbe-associated molecular patterns (MAMPs) probe plant immunity. Current Opinion in Plant Biology. 2007; 10 :335-341 - 105.
Hammerschmidt R, Hollosy SI. Phenols and the onset and expression of plant disease resistance. In: Daayf F, Lattanzio V, editors. Recent Advances in Polyphenol Research. Vol. 1. Oxford, UK: Wiley-Blackwell; 2008. pp. 211-227 - 106.
Heil M. Indirect defence via tritrophic interactions. The New Phytologist. 2008; 178 :41-61 - 107.
Me’traux J-P, Lamodie’re E, Catinot J, Lamotte O, Garcion C. Salicylic acid and induced plant defenses. In: Daayf F, Lattanzio V, editors. Recent Advances in Polyphenol Research. Vol. 1. Oxford, UK: Wiley-Blackwell; 2008. pp. 202-210 - 108.
Zipfel C. Pattern-recognition receptors in plant innate immunity. Current Opinion in Immunology. 2008; 20 :10-16 - 109.
Nicaise V, Roux M, Zipfel C. Recent advances in PAMP-triggered immunity against bacteria: Pattern recognition receptors watch over and raise the alarm. Plant Physiology. 2009; 150 :1638-1647 - 110.
Wu J, Baldwin IT. Herbivory-induced signalling in plants: Perception and action. Plant, Cell & Environment. 2009; 32 :1161-1174 - 111.
Postel S, Kemmerling B. Plant systems for recognition of pathogen-associated molecular patterns. Seminars in Cell & Developmental Biology. 2009; 20 (9):1025-1031 - 112.
Mikulic-Petkovsek M, Slatnar A, Veberic R, Stampar F, Solar A. Phenolic response in green walnut husk after the infection with bacteria Xanthomonas arboricola pv.juglandis . Physiological and Molecular Plant Pathology. 2011;76 (3-4):159-165 - 113.
Cho M, Lee S. Phenolic phytoalexins in rice: Biological functions and biosynthesis. International Journal of Molecular Sciences. 2015; 16 (12):29120-29133 - 114.
Wang L, Sun R, Zhang Q, Luo Q, Zeng S, Li X, et al. An update on polyphenol disposition via coupled metabolic pathways. In: Expert Opinion on Drug Metabolism & Toxicology. London: Ashley Publications; 2018. pp. 1-15 - 115.
Ansari MA, Fatima Z, Hameed S. Sesamol: A natural phenolic compound with promising anticandidal potential. Journal of Pathogens. 2014; 2014 :895193 - 116.
Upadhyay A, Mooyottu S, Yin H, Nair M, Bhattaram V, Venkitanarayanan K. Inhibiting microbial toxins using plant-derived compounds and plant extracts. Medicine. 2015; 2 :186-211 - 117.
Negritto MC, Valdez C, Sharma J, Rosenberg C, Selassie CR. Growth inhibition and DNA damage induced by X-phenols in yeast: A quantitative structure-activity relationship study. ACS Omega. 2017; 2 (12):8568-8579 - 118.
Fernandes KRP, Bittercourt PS, Souza ADL, Souza AQL, Silva FMA, Lima ES, et al. Phenolic compounds from Virola venosa (Myristicaceae) and evaluation of their antioxidant and enzyme inhibition potential. Acta Amaz. 2019;49 (1):48-53 - 119.
Gallego-Giraldo L, Escamilla-Trevino L, Jackson LA, Dixon RA. Salicylic acid mediates the reduced growth of lignin down-regulated plants. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108 :20814-20819 - 120.
Gallego-Giraldo L, Jikumaru Y, Kamiya Y, Tang Y, Dixon RA. Selective lignin downregulation leads to constitutive defense response expression in alfalfa ( Medicago sativa L.). The New Phytologist. 2011;190 :627-639 - 121.
Widodo GP, Sukandar EY, Adynyana IK. Mechanism of action of coumarin against C. albicans by SEM/TEM analysis. ITB Journal of Science. 2012;44A :145-151 - 122.
Rahman AU. Studies in Natural Product Chemistry. Vol. 24. Amesterdam: Elsevier; 2000 - 123.
Al-Barwani FM, Eltayeb EA. Antifungal compounds from induced Conium macultum L. plants. Biochemical Systematics and Ecology. 2004;32 :1097-1108 - 124.
Al-Amiery AA, Kadhum AA, Mohamad AB. Antifungal activities of new coumarins. Molecules. 2012; 17 (5):5713-5723 - 125.
Serpa R, Franca EJ, Furlaneto-Maia L, Andrade CG, Diniz A, Furlaneto MC. In vitro antifungal activity of the flavonoid baicalein against Candida species. Journal of Medical Microbiology. 2012; 61 :1704-1708 - 126.
Zuzarte M, Vale-Silva L, Goncalves MJ, Cavaleiro C, Vaz S, Canhoto J, et al. Antifungal activity of phenolic-rich Lavandula multifida L. essential oil. European Journal of Clinical Microbiology & Infectious Diseases. 2012;31 (7):1359-1366 - 127.
Belofsky G, Kolaczkowski M, Adams E, Schreiber J, Eisenberg V, Coleman CM, et al. Fungal ABC transporter-associated activity of isoflavonoids from the root extract of Dalea formosa . Journal of Natural Products. 2013;76 (5):915-925 - 128.
Sherwood P, Bonello P. Austrian pine phenolics are likely contributors to systemic induced resistance against Diplodia pinea . Tree Physiology. 2013;33 (8):845-854 - 129.
Anttila A-K, Pirttilä AM, Häggman H, Harju A, Venäläinen M, Haapala A, et al. Condensed conifer tannins as antifungal agents in liquid culture. Holzforschung. 2013; 67 (7):825-832 - 130.
Dos Santos C, Vargas Á, Fronza N, Dos Santos JHZ. Structural, textural and morphological characteristics of tannins from Acacia mearnsii encapsulated using sol-gel methods: Applications as antimicrobial agents. Colloids and Surfaces B: Biointerfaces. 2017;151 :26-33 - 131.
Rashed YM, Aseel DG, Hafez EE. Antifungal potential and defense gene induction in maize against Rhizoctonia root rot by seed extract of Ammi visnaga (L.) Lam. Phytopathologia Mediterranea. 2018;57 (1):73-88 - 132.
Marques JPR, Hoy JW, Appezzato-da-Glória B, Viveros AFG, Vieira MLC, Baisakh N. Sugarcane cell wall-associated defense responses to infection by Sporisorium scitamineum . Frontiers in Plant Science. 2018;9 :698 - 133.
Ogawa S, Yazaki Y. Tannins from Acacia mearnsii De wild. Bark: Tannin determination and biological activities. Molecules. 2018;23 (4):E837 - 134.
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. Scientific World Journal. 2013; 2013 :162750 - 135.
Zakaryan H, Arabyan E, Oo A, Zandi K. Flavonoids: Promising natural compounds against viral infections. Archives of Virology. 2017; 162 (9):2539-2551 - 136.
Shokoohinia Y, Sajjadi SE, Gholamzadeh S, Fattahi A, Behbahani M. Antiviral and cytotoxic evaluation of coumarins from Prangos ferulacea . Pharmaceutical Biology. 2014;52 (12):1543-1549 - 137.
Dunkić V, Bezić N, Vuko E, Cukrov D. Antiphytoviral activity of Satureja montana L. ssp.variegata (host) P. W. Ball essential oil and phenol compounds on CMV and TMV. Molecules. 2010;15 (10):6713-6721 - 138.
Hu Q-F, Zhou B, Huang J-M, Gao X-M, Shu L-D, Yang G-Y, et al. Antiviral phenolic compounds from Arundina gramnifolia . Journal of Natural Products. 2013;76 (2):292-296 - 139.
Zhao W, Zeng XY, Zhang T, Wang L, Yang GY, Chen YK, et al. Flavonoids from the bark and stems of Cassia fistula and their anti-tobacco mosaic virus activities. Phytochemistry Letters. 2013;6 :179-182 - 140.
Li L, Xu W-X, Liu C-B, Zhang C-M, Zhao W, Shang S-Z, et al. A new antiviral phenolic compounds from Arundina graminifolia . Asian Journal of Chemistry. 2015;27 :3525-3526 - 141.
Liu CB, Shen QP, Wang Y, Zhang FM. Coumarins from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities. Chemistry of Natural Compounds. 2016;52 :992-995 - 142.
Fraenkel G. The raison d’eˆtre of secondary plant substances. Science. 1959; 129 :1466-1470 - 143.
Cornell HV, Hawkins BA. Herbivore responses to plant secondary compounds: A test of phytochemical coevolution theory. The American Naturalist. 2003; 161 :507-522 - 144.
Lattanzio V, Lattanzio VMT, Cardinali A. Role of phenolics in the resistance mechanisms of plants against fungal pathogens and insects. In: Imperato F, editor. Phytochemistry: Advances in Research. Trivandrum: Research Signpost; 2006. pp. 23-67 - 145.
Bhattacharya A, Sood P, Citovsky V. The roles of plant phenolics in defence and communication during Agrobacterium and Rhizobium infection. Molecular Plant Pathology. 2010; 11 :705-719 - 146.
Maxwell FG, Lafever HN, Jenkins JN. Blister beetles on glandless Cotton1. Journal of Economic Entomology. 1965; 58 :792-793. DOI: 10.1093/jee/58.4.792 - 147.
Feeny P. Seasonal changes in oak leaf tannins and nutrients as a cause of spring feeding by winter moth caterpillars. Ecology. 1970; 51 :565-581. DOI: 10.2307/1934037 - 148.
Levin DA. Plant phenolics: An ecological perspective. The American Naturalist. 1971; 105 (942):157-181 - 149.
Hedin PA, Jenkins JN, Thompson AC, McCarty JC, Smith DH, Parrott WL, et al. Effect of bioregulators on flavonoids, insect resistance and yield of seed cotton. Journal of Agricultural and Food Chemistry. 1988; 36 :1055-1061 - 150.
Luczynski A, Isman MB, Raworth DA. Strawberry foliar phenolics and their relationship to development of the two spotted spider mite. Journal of Economic Entomology. 1990; 83 :557-563. DOI: 10.1093/jee/83.2.557 - 151.
Byers JA. Host-tree chemistry affecting colonization in bark beetles. Chemical Ecology of Insects. 1995; 2 :154-213 - 152.
Lee DW, Gould KS. Why leaves turn red. American Scientist. 2002; 90 :524-531 - 153.
Gould KS. Nature’s Swiss army knife: The diverse protective roles of anthocyanins in leaves. Journal of Biomedicine & Biotechnology. 2004; 5 :314-320 - 154.
Archetti M. Decoupling vigour and quality in the autumn colours game: Weak individuals can signal, cheating can pay. Journal of Theoretical Biology. 2009; 256 :479-484 - 155.
Archetti M, Döring TF, Hagen SB, Hughes NM, Leather SR, Lee DW, et al. Unravelling the evolution of autumn colours: An interdisciplinary approach. Trends in Ecology & Evolution. 2009; 24 :166-173 - 156.
Nikiforou C, Manetas Y. Strength of winter leaf redness as an indicator of stress vulnerable individuals in Pistacia lentiscus . Flora. 2010;205 :424-427 - 157.
Hughes NM. Winter leaf reddening in “evergreen” species. The New Phytologist. 2011; 190 :573-581 - 158.
Rehman F, Khan FA, Badruddin SMA. Role of phenolics in plant defense against insect herbivory. In: Chemistry of Phytopotentials: Health, Energy and Environmental Perspectives. Berlin/Heidelberg: Springer; 2012. pp. 309-313 - 159.
Fürstenberg-Hägg J, Zagrobelny M, Bak S. Plant defense against insect herbivores. International Journal of Molecular Sciences. 2013; 14 :10242-10297. DOI: 10.3390/ijms140510242