\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
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\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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\r\n\tWith the discovery of more unconventional heavier crude and alternative hydrocarbon sources, primary upgrading or cracking of the oil into lighter liquid fuel is critical. With increasing concern for environmental sustainability, the regulations on fuel specifications are becoming more stringent. Processing and treating crude oil into a cleaner oil with better quality is equally important. Hence, there has been a relentless and continuous effort to develop new crude upgrading and treating technologies, such as various catalytic systems for more economical and better system performance, as well as cleaner and higher-quality oil.
\r\n\tThis edited book aims to provide the reader with an overview of the state-of-the-art technologies of crude oil downstream processing which include the primary and secondary upgrading or treating processes covering desulfurization, denitrogenation, demetallation, and evidence-based developments in this area.
",isbn:"978-1-80356-681-8",printIsbn:"978-1-80356-680-1",pdfIsbn:"978-1-80356-682-5",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"808b0ddfb3b92e0636ae44a83ef7dbd9",bookSignature:"Dr. Ching Thian Tye",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11542.jpg",keywords:"Crude Oil Properties, Hydrocracking, Catalytic Cracking, Coking, Visbreaking, Thermal Cracking, Hydroprocessing, Hydrodesulfurization, Desulfurization, Denitrogenation, Demetallation, Dearomatization",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2022",dateEndSecondStepPublish:"April 19th 2022",dateEndThirdStepPublish:"June 18th 2022",dateEndFourthStepPublish:"September 6th 2022",dateEndFifthStepPublish:"November 5th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Associate professor at the School of Chemical Engineering in Universiti Sains Malaysia and dedicated researcher in fuel-related catalytic process and chemical reaction engineering. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"58148",title:"Cortisol in Correlation to Other Indicators of Fish Welfare",doi:"10.5772/intechopen.72392",slug:"cortisol-in-correlation-to-other-indicators-of-fish-welfare",body:'\nStress triggers reactions in all living organisms, and fish are no exception to this rule. It is known that fish are exposed to stress, not only in nature but also in aquaculture, fish markets and laboratories. In the past decades, knowledge and understanding of stress in fish has increased, particularly in the field of physiological mechanisms and responses that lead to changes in metabolism, growth, immune function, reproductive capacity and natural behavior. Interestingly, fish have proved to be more sensitive to stressors than many other vertebrates and responded to stressors at the intensity levels that are often far below those that can be detected by terrestrial animals [1, 2, 3, 4]. The stress response in fish has been widely categorized into the primary, secondary and tertiary responses [5, 6, 7, 8, 9, 10, 11]. The primary response (the neuroendocrine response) includes the rapid release of stress hormones, catecholamines and corticosteroids, into the circulation [1, 12, 13]. This physiological response to stressors encompasses activation of the brain-sympathetic-chromaffin cell (BSC) axis and the hypothalamic-pituitary-interrenal (HPI) axis [1] (Figure 1). During the BSC axis activation, chromaffin cells of the head kidney release catecholamines (adrenaline and noradrenaline) from sympathetic nerve terminals. Catecholamines are controlled by factors released from sympathetic nerve terminals, mainly acetylcholine and angiotensin. The action of catecholamines includes increased hemoglobin oxygen affinity, arterial blood pressure [14] and glucose mobilization from liver and muscles [1]. The activation of HPI axis comprises the corticotropin-releasing factor (CRF) release from the hypothalamus, which in turn stimulates the corticotrophic cells in the anterior pituitary to secrete adrenocorticotropic hormone (ACTH). Following that, the interrenal cells of the head kidney synthesize and release cortisol into the circulatory system. In teleosts, the head kidney a major endocrine, hematopoietic and lymphatic tissue, are the equivalent of the adrenal gland in mammals [1, 12]. The secondary response comprises the various biochemical and physiological effects such as metabolic changes (increased glucose and lactate in blood and decreased tissue glycogen), osmoregulatory disturbance (water/ion balance), changes in hematological features (hematocrit, leukocrit and hemoglobin), cellular changes (increased heat shock or stress protein production) and changes in the immune response (lysozyme activity and antibody production) [13, 15, 16, 17]. The tertiary response represents changes in whole-animal performance characteristic (growth, swimming capacity and disease resistance) and modified behavioral patterns (feeding, aggression and reproduction) (“for review [9, 11, 18]”).
\nThe stimulation of BSC axis and HPI axis in response to stress in fish.
In fish, cortisol acts as a regulatory factor for a wide range of physiological functions under normal conditions and also to allow for rapid physiological adjustments in the face of exposure to stressors [13]. Cortisol appears to play a pivotal role in the aerobic and anaerobic metabolism, stimulating several aspects of intermediary energy metabolism, elevating oxygen uptake, increasing gluconeogenesis and inhibiting synthesis of glycogen synthesis [1, 13, 19, 20, 21]. Furthermore, increases in plasma corticosteroids have a wide range of other metabolic effects including increases in protein turnover, regulation of amino acid metabolism, ammonia output and increased lipolysis (“reviewed in [13]”). This hormone also performs an osmoregulatory function in teleosts, being the main hormone for seawater adaptation and ion uptake [22, 23]. Moreover, cortisol may regulate the immune response in fish [1, 13, 24]. Cortisol modulates, among others, the tissue inflammatory response through inhibitory effects on cytokine production [25] and appears to attenuate the cellular heat shock protein response to thermal insult [26, 27]. Corticosteroid hormones may highly participate in the modulation of the reproductive endocrine control in both sexes [18].
\nIt should be noted that cortisol dramatically rises during stress and seems to be a key mediator of stress-associated responses [13, 28]. There is considerable variability in the magnitude of the corticosteroid response among species [9, 29, 30]. Among teleosts, some species exhibit high cortisol concentrations (10−7–10−6 M) in response to acute stress [9], while some species reveal low cortisol levels (10−9–10−8 M) in response to the same stress [31, 32, 33]. Most fish species show their increase in plasma cortisol within about 0.5–1 hour after a stressful disturbance [34, 35], but there are exceptions to the role. In the sea raven (
Although cortisol is universally recognized as a critical component of the endocrine response to stress, other hormones are also involved in the stress response, e.g., arginine vasotocin (AVT), isotocin (IT), urotensins, dopamine, serotonin or β-endorphin [13, 44, 45, 46, 47, 48]. However, other hormones, such as thyroxine, prolactin and somatolactin can also elevate during stress but they have not yet been demonstrated to be useful stress indicators
Nonapeptides, such as AVT and IT, are fish homologs of the mammalian arginine vasopressin (AVP) and oxytocin (OT) [52]. In fish, AVT and IT are synthesized in separate parvo- and magnocellular neurons of the preoptic area (POA), stored in axon terminals in neurohypophysis and released into the circulatory system after proper stimulation [53, 54, 55]. Only mature nonapeptides, after dissociation from the noncovalent complex, play an active role as peripheral hormones and neurotransmitters or neuromodulators in the central nervous system (CNS). The physiological role of AVT involves cardiovascular activity and maintenance of water/ion homeostasis. Both nonapeptides interact with other endocrine systems and control social and reproductive behavior [56, 57, 58, 59]. More importantly, there is evidence that AVT and IT are engaged in physiological stress response in fish. Changes in hypothalamic, pituitary and plasma AVT and IT concentrations were found in many fish species subjected to various unfavorable situations such as confinement, disturbance, high density, food deprivation or osmoregulatory stress [33, 47, 60]. Therefore, AVT and IT are important components of stress axis in fish [61]. Moreover, AVT neurons are colocalized with CRF in the preoptic nucleus (NPO) [62, 63], and the expression of AVT and CRF mRNAs increases simultaneously in response to various stressors in many fish spices [56, 64, 65].
It has been known that UI is implicated in the regulation of neuroendocrine, autonomic and behavioral responses to stressors in fish [71, 72]. Gene expression of UI was found not only in urophysis but also in the telencephalon-preoptic, hypothalamic, optic tectum-thalamus and posterior brain regions, which indicates the regulatory action of this peptide in CNS [73, 74, 75]. The structural similarity of UI with CRF suggests similar hypophysiotropic roles of both hormones in HPI axis in fish [76, 77, 78]. It has been established that UI modulates cortisol secretion either directly by acting on steroidogenic cells of an interrenal tissue or indirectly via the hypothalamic-pituitary axis [71, 77, 79, 80]. In many fish species, UI-immunoreactive (UI-ir) fibers from the nucleus lateral tuberalis (NLT) extend to the pituitary where they may interact with AVT and IT nerve terminals [81, 82, 83, 84].
\nThe effect of cortisol on AVT has been examined
The study performed by Kalamarz-Kubiak et al. [86] demonstrated that AVT and IT secretion from nerve ending of
For the reasons mentioned above, it was presumed that UI, instead of CRF, might regulate AVT and IT release in
Cortisol affects AVT and IT secretion from nerve endings in
Cortisol stimulates AVT secretion in a dose-dependent manner and inhibits IT secretion in
UI stimulates AVT secretion but does not influence IT secretion from nerve endings in
UI instead of CRF may contribute to the regulation of HPI axis and regulate AVT secretion.
AVT and IT are essential components of stress response in fish.
At the beginning of this chapter, it was noticed that besides cortisol, urotensins are also involved in the response to stress in fish. UI action has already been discussed. In turn, urotensin II (UII), a cyclic peptide originally isolated from the urophysis of the goby (
From those results, the following conclusions were formulated:
UII affects AVT and IT release from nerve endings in the pituitary of gilthead sea bream.
UII inhibits AVT release and stimulates release of IT in
UII together with AVT and IT may control response to different salinities in fish.
The hormonal interactions between UII and AVT and IT are presented in Figure 2.
\nThe effect of cortisol, urotensin I and urotensin II on arginine vasotocin and isotocin secretion in gilthead sea bream.
It has been established that cortisol has both a corticosteroid and a mineralocorticoid function in fish [1]. An involvement of both classes of corticoid receptors (CRs), mineralocorticoid (MRs) and glucocorticoid (GRs), was widely demonstrated during adaptation to different salinities and osmoregulatory stress [141, 142, 143, 144], fish reproduction [145, 146] and expression of social behavior [147, 148, 149]. It is worth noting that both MRs and GRs were engaged in tilapia’s response to handling stress [150] and expressed in rainbow trout organs with slow-release cortisol implants [151].
\nGlucocorticoid and mineralocorticoid receptors are involved in the genomic and nongenomic mechanisms of cortisol action in fish [149, 152, 153]. Corticosteroid-intracellular receptor complex binds to the nuclear glucocorticoid response elements (GRE) to modulate transcription and protein synthesis (genomic pathway) [13, 25, 154]. The nongenomic effect is mediated through either nonspecific physicochemical interaction with the plasma membrane [155] or specific membrane receptors such as the G protein–coupled receptor (GPCR) [156] or the plasma membrane-bound form of GR (mGRs) (nongenomic pathway) [157]. (“Nongenomic steroid action is presented in accordance with Mannheim classification [155].”)
\nRecently, there is growing concern about effects of farming and environmental pollution on fish well-being; thus, there is the need for new tests to study the endocrine responses in fish [158]. Furthermore, fish are increasingly being used as substitutes for mammalian model organisms in fundamental research and as a research model for chemical testing. Hence, research must remain focused on the discovery of new alternative techniques or on an adaptation of methods established for mammalian models for use as fish models [159].
\nThe mechanism presented in this section requires a method that allows monitoring the dynamic hormone secretion and registering even small and short-term fluctuations in their release. Only perfusion culture method allows detailed examination of changes in the release of hormones while ensuring optimal culture conditions. Kalamarz-Kubiak et al. [160] developed a new procedure for the unique gradient perfusion technique (3D) of brain and pituitary explants collected from three-spined stickleback (
The schemes of culture sets used for gradient perfusion. Components of perfusion culture set: (1) storage medium bottles, (2) peristaltic pumps, (3) connecting fittings, (4) gas exchange modules, (5) gradient culture container, (6) sampling vials. The release of arginine vasotocin and isotocin during tests of these sets (graphs).
The schemes of sets used for gradient perfusion and graphs of AVT and IT release during tests of those sets are presented in Figure 3.
\nIn teleost, two different GR coding genes (GR1 and GR2) and one MR gene were found [171, 172]. The expression of GR1, GR2 and MR genes, as well as the immunoreactivity of GRs (GRs-ir), was noted in most of the magno- and parvocellular neurons of the preoptic nucleus (NPO), known for synthesizing AVT, IT and CRF, in tilapia (
As it was mentioned earlier, AVT and IT are engaged in physiological stress response and seem to be important components of stress axis in fish [33, 47, 61]. In gilthead sea bream, the application of cortisol implants in this species enhanced the hypothalamic expression of provasotocin mRNA and pituitary AVT content [85]. What is more, an
In results presented by Kalamarz-Kubiak et al. [176], the stimulation of IT secretion by cortisol appeared within 20 minutes and persisted for the next 100 minutes, similarly as in the case of AVT, but did not disclose a biphasic character. The nongenomic, stimulatory effect of cortisol
In fish, the cortisol effects are mediated through both the GRs but also through MRs [1]. However, the
Outside the scope of this study, an opposite effect, i.e., the stimulation of cortisol secretion by AVT, should also be considered. There is evidence that AVT neurons innervate corticotrophic cells in green molly (
From those data, the following conclusions were formulated:
Cortisol affects AVT and IT secretion from the H-P complex in round goby.
Cortisol stimulates the release of both nonapeptides. However, the effect of cortisol on AVT release is dose-dependent.
Cortisol has biphasic effects on the release of AVT, while this effect on IT is monophasic.
GRs but not MRs are involved in cortisol regulation of AVT and IT release.
In the case of AVT, both genomic and nongenomic pathways mediate the effect of cortisol.
In the case of IT, only the nongenomic pathway mediates the effect of cortisol.
The mechanism of cortisol action on AVT and IT release in round goby are presented in Figure 4.
\nThe mechanism of cortisol action on arginine vasotocin and isotocin release in round goby.
The purpose of this chapter was to gain new knowledge on the involvement of cortisol and other indicators of fish welfare in the regulation of stress response in fish. The basis of the subject was to assume that both nonapeptides and urotensins are essential components of stress response in fish. So far, nobody has attempted to check if there is a functional relationship between cortisol and both nonapeptides and urotensins using
In conclusion, it is worth to quote the statement of Victoria Braithwaite [200], about the pain and stress in fish, for The Los Angeles Times dated October 8, 2006: “Their brains are not as different from ours as we once thought. Although less anatomically complex than our own brain, the function of two of their forebrain areas is very similar to the mammalian amygdala and hippocampus – areas associated with emotion, learning and memory. If these regions are damaged in fish, their learning and emotional capacities are impaired; they can no longer find their way through mazes, and they lose their sense of fear”.
\nThe importance of the consumers’ perception of the country of origin, which is a strategic aspect for the Italian fashion industry, dates back to the first decades of the XXth century. In fact, a first set of studies addressing the perception of the countries can already be found in the 1930s and 1940s [1, 2, 3, 4]. Since then, the fact that country images are both the cause and effect of social as well as psychological processes, together with the multitude of their possible economic, cultural and political effects, have led to various studies across a range of scientific fields. From the perspective of business studies, different concepts have been developed in the subfield of marketing with a focus on nation brands as well as country of origin effects: country of manufacturing [5], country of design [6], country of brand [7], country of origin image [8].
In the field of communication management Passow et al. [9] and Yang et al. [10] applied a model focused on corporate reputation in analyses of country reputation. Buhmann [11] applies the 4D model to analyze image transfer and halo effects between companies and their country of origin.
To assure the exact country of origin of a product and also to consider other strategic issues such as the prove that the garments are not counterfeited, business operators of the fashion industry may adopt recent technologies, such as RFId tags.
The aim of this study is to present a case study in the fashion sector related to an Italian family business. One of the key elements of this company, Oscalito, is undoubtedly the link between tradition and innovation, the latter realized also thanks to the use of RFId technology.
Oscalito has been preserving and defending an authentically Made in Italy supply chain for 80 years and its clothing line is closely related to Italian tradition of high-quality standards.
Oscalito, established in 1936, initially created clothing lines of underwear and fashion knitwear for men, women and children, using high quality natural fibers. After the disasters of World War II, in a building located in Torino (Italy) alongside the Po river, the Casalini brothers (Osvaldo and Lino) set up two knitting machines that had survived the war and started production again, in a country where reconstruction was enthusiastically underway. The logo of the company is shown in Figure 1.
Oscalito’s logo. Source: Oscalito.
In 2012, Oscalito started the use of RFId tags, linking the tradition in quality of their outputs with innovation and technologies.
This study, which is part of a branch of research (fashion industry and new technologies) carried out by the Authors [12, 13, 14] fills a gap in the literature: to the Authors’ knowledge, this is the first paper which presents a case study of an Italian family business company able to joint with success tradition and innovation technologies.
This chapter is divided into 4 sections: Section 2 presents the research methodology; Section 3 is focused on Oscalito, the case study, while the final conclusions are drawn in Section 4.
With the aim to realize the objective of this research, the following hypothesis has been developed:
H1.
The Authors decided to apply a qualitative case study methodology for exploring this experience within its context [15, 16]. As stated by Yin [17, 18], the selection of this method is justified because there is the necessity to answer “how” and “why” and furthermore because the Authors are not able to influence the conduct of those involved in the research. Last, but not least, the study is focused on an up-to-date experience.
The Authors have chosen Oscalito company to focus their research because it is a pretty unique case [17, 19, 20]: it has maintained a strong tradition while innovation technologies have been introduced to monitor all the supply chain.
With the aim to deeply investigate this case study, a large variety of sources of information have been used.
As this research has been realized during the COVID-19 pandemic crises (October 2020), the data triangulation suggested by Eisenbardt, [21] was realized with some adaptations due to the current situation: it was obviously not possible to conduct a direct observation in the company buildings, but Authors were invited to some online meeting to have the opportunity to observe the company behavior in real time. A lot of time has been dedicated for the analysis of company documents (reports, studies, memoranda etc.) and interviews (the managing director and other people in the company) thanks to online meetings with video and screen sharing. All these actions allowed the Authors to deeply examine the company.
Each interview lasted for approximately 45 minutes and was conducted by both Authors.
Further information was collected from the company website.
All the collected data were analyzed autonomously by the two Authors and then compared.
In accordance with Ying’s categorization of case studies, this is a “descriptive” one: it defines a “phenomenon and the real-life context in which it occurred” [16, 17].
The beginning of Oscalito’s production was basically characterized by use of tubular fabric (without stitching), using circular machines. Lino’s sons, Arrigo and Andrea, later joined the firm, extending the product range to fashion clothes and gaining success even on foreign markets: today a total of 60% of its revenue comes from exports.
Andrea began to experiment with designs on wild and pattern textile machines and with new yarns and fashion garments, broadening the range to more fashionable items. His innovations found favor on the USA market, while orders, commitments and production took off.
In 1975 Arrigo joined the company, giving a fresh boost to sale and the following years were marked by constant growth: women’s fashion items began to play a central role as the export market became increasingly important. Oscalito is a family-controlled business as Casalini family has more of its members in key management positions. [22, 23]
The role of entrepreneurship and the culture for facilitating internationalization efforts is clearly powered at Oscalito and ensures a company’s long-term competitive advantage: most business originally begin as family business then evolve into larger business, depending on performance. [24].
While Oscalito constantly innovates, it remains true to its core values: turning out first-class garments meant to be worn next to the skin, using natural fibers relying on an entirely Italian supply chain. The narrow space between skin and undergarment determines the comfort; this microclimate’s temperature and humidity is kept in perfect balance by living natural fibers. These react with the external environment just as they do in nature, absorbing or releasing heat and water-vapor molecules. With synthetic fibers, which are non-absorbent, moisture remains on the skin.
In 2014, the third generation joined the company as Dario Casalini, gradually took over the reins in a spirit of continuity, refreshing the brand while expanding onto the international market.
The positioning is the result of the company intention to offer superb comfort, quality, well-being in a unique, original and recognizable style [25].
Nowadays, RFId technology is commonly used for monitoring food [26] and non-food products.
In the textile sector the implementation of RFId technology is considered a huge prospective.
The literature, for instance, has put into evidence that a resource allocation system which uses RFId tags is able to ensure more effective processes than those realized by conventional procedures [27], furthermore, it has been demonstrate the positive impact realized along the supply chain thanks to the application of these tags [28].
Many brands (for example Tesco, Wal-Mart, Benetton, Prada, and, recently, Zara [29]) have already examined the implementation of this technology [30].
It is in this context that Oscalito, since 2012, has decided to adopt the RFId technology, which is applied to each label, to ensures complete traceability throughout the production chain.
This technology uses radio-frequency to recognize, find and trace things [31]. The company uses RFId tag for each single garment (and not merely by lots): this allows fine-tuned control over the production process, and timely and accurate shipment.
Additional considerations related to RFId technology for monitoring the supply chain and for fighting against counterfeiting may be found in this already published chapter [14].
RFId technology has emerged as a valid support for the company not only to monitor the supply chain, but also to protect the Italian origin of production, improving the link with the company’s tradition.
In the next paragraphs, further suggestions about the company’s use of RFId tags will be provided.
Upon analysis of the industry using the Porter’s Five Forces Framework [32, 33, 34, 35] Authors may affirm that competition within the industry is very high due to the number and the different purposes of competitors, and that the competitive pressure especially derives from chains and department stores.
Oscalito exports about 60% of its products, therefore its main competitors are foreign companies such as Hanro and Zimmerli, which manufacture in Switzerland.
Its suppliers have a high bargaining power, in that Oscalito – to maintain the same level of excellence of the natural fibers and Made in Italy mark – sources extremely high-quality raw materials from a very restricted niche of suppliers.
Its customers also have a high bargaining power due to low switching costs that push them to spend less money on underwear products by purchasing from competitors that produce low-cost products and sell them at accessible prices.
Barriers to entry are high – due to the sector’s high competition level – with the only relevant threat being the recent emergence of e-commerce underwear companies attempting to enter the sector. The threat from substitute goods is low, but the high quantity of competitors does offer numerous alternatives to Oscalito products.
Hanro and Zimmerli and all others direct Oscalito’s competitors do not’ use RFId tags: without the application of this technology, the supply chain and the subcontracting (for instance those linked to East Europe, Portugal, China and India) are not put in evidence.
RFId tags may be considered as a competitive advantage only for the retailers receptive to the “Made in” topic, which, nowadays are still a tiny minority.
The source of Oscalito’s competitive advantage lies in its differentiation [36, 37], allowing the company to impose a premium price thanks to the high fiber quality, product excellence, and Made in Italy mark.
Customers are willing to pay a premium price as they can perceive the higher quality offered by the company as opposed to its competitors.
Another source of competitive advantage is the product innovation pursued through use of tubular machines (Figure 2), allowing the company to produce seamless knitwear.
Tubolar knitting machines. Source: Oscalito.
RFId technology enable consumers to be fully informed on the origin of the products and protect them from misleading indications of origin.
As well as its differentiation strategy, Oscalito also pursues cost advantage, especially by means of process innovation. Its slow production allows close control of the vertically integrated supply chain. Moreover, it achieves cost reduction through innovative use of RFId tags, which allow tracking of every single item of clothing throughout its entire lifecycle, all the way to its sale to the end user, thus a guarantee of full traceability and extensive control over manufacturing and shipping. RFId is useful for monitoring supply chains and as tools for fighting against counterfeiting [14].
Upon analysis through Porter’s Value Chain, one may comprehend the uniqueness of Oscalito products, and how the company manages to turn input to high-quality output by means of vertically integrated activities within a fully Made in Italy supply chain.
The production phases range from yarn spinning to the finished product: weaving, fabric finishing, cutting, sewing, finishing of the end product, quality control, and warehouse logistics.
The initial phases (weaving and fabric finishing) are performed using bar codes, bearing all the information related to the manufacturing steps to make the finished product; such data is then transmitted via the RFId antenna. In the cutting phase, the cutting slip includes details of the fabric bolt or bolts, and the sewing slip includes bar code details related to the bolt, the cut area, and the Bill of Materials, which also includes the past details related to the bolt, the cut area, finishing, and origin of the thread.
When the item is complete an RFId tag is applied – containing the above information – in that, until that moment, it is simply considered a unit of production. Upon application of the tag, the logistics history of the item becomes independent and contains data related to shipping, recipient, store to which the product is shipped, and quantity sold (only for wholly-owned stores and franchisees).
Figure 3 shows some crucial phases of Oscalito’s production.
Some phases of Oscalito’s production. a) Design and prototyping; b) lace cutting c) rib fabric manual catting d) sewing line. Source: Oscalito.
Oscalito’s levers of success may be identified upon analysis of the marketing mix.
The brand’s products are made of extremely high-quality natural fibers, and the slow production philosophy preserves such quality and guarantees maximum wellness to its end users.
The premium price applied to the goods is justified by their quality level, and consequently the customer perceives an excellent value for money.
The promotion and communication policy are mainly based upon the Made in Italy mark, and Oscalito transmits an image coherent with its brand values through elegant, refined, and neutral-colored retail outlets.
The products are distributed to a number of countries through independent agents, distributors, monobrand stores and – in certain countries – the e-commerce channel.
The vision is to wear 100% Italian, high-quality underwear or knitwear.
In order to compete with the players in the fast fashion business – offering the same functional benefits as Oscalito – the company needs to leverage its social and emotional unique selling proposition, making consumers conscious of the greater benefits that purchasing Oscalito products may imply.
Elegance-conscious consumers with a middle-high income experience a feeling of great wellness offered by the natural fibers that preserve the necessary microclimate for maximum comfort.
Oscalito stands out from its competitors due to the raw materials and manufacturing technology it uses to create its products, with a constant commitment to investigating new styles and developing new production methods in line with environmental responsibility.
At the end of the year 1990, the company created a sorting system for processing stations based upon an IT system: each processing station is automatically distributed by a CPU to the various processing machines. After the sewing phase, each item of clothing undergoes quality control (Figure 4), which allows only 1% of company products to go to waste.
a) and b) quality control on shaping lamps. Source: Oscalito.
Since its establishment and until the 1980s, Oscalito had a single sales network: independent agents (as the company did not have the necessary turnover to hire exclusive agents) who also sold complementary products.
In the fashion industry, the evolution of the supply system has had a strong impact on the market.
From the business point of view, regardless of the size, management of distribution channels is a crucial element that may determine the success or failure of the firm itself. Within such sector, manufacturers and large brands offer a value proposition that depends on the combination of physical traits of the product but also its related intangible elements and services [38].
Oscalito has recently opened an e-commerce platform in the United States.
When a sales network is deeply enrooted in a Country, it becomes dangerous to launch and e-commerce platform, in that other retailers view it as a direct competitor. This danger exists both in Italy and France, where the retail network is deeply entrenched. Launching an e-commerce platform also implies an increase in stock and in investment in logistics.
On average, in the clothing sector 12% of turnover is spent on marketing. Oscalito, instead, spends 1%. In order to compensate such lack, the company has adopted a number of solutions: seminars for retailers in Italy and France; and industrial tourism, namely visits to the company. The problem is that it is crucial to the company that retailers inform customers about the Oscalito production process and product.
Oscalito belongs to company networks that offer promotion of the brand through free-of-charge advertisement, namely Italian Lingerie Export and Exclusive Brand Torino. Italian Lingerie Export is the consortium bringing together Italian companies that manufacture high-quality lingerie. Exclusive Brand Torino is the consortium for the promotion of selected brands and top products from the Piedmont area on the foreign market, whose member companies share a set of values, such as attachment to the territory and excellence. Nevertheless, the consortium’s multi-sector nature is also an obstacle, in that it struggles to offer common initiatives.
Since now, Oscalito has not implemented marketing strategies for consumers focused on the application of RFId tags even because, from the company point of view, it is not easy to choose which are the appropriate information that can be given to the consumers. It is crucial not to benefit competitors (for instance, indicating which material allow to obtain a certain high-quality) or to avoid creating problems to the retailers (the indication of the date of production may reveal the consumer that the item has been stored for a long time).
Countries offering the greatest opportunities in the fashion industry are developing countries such as China, India, and Japan.
An additional market that has recently gained high relevance in the sector is the Iranian market, especially in terms of luxury European brands, due to the abolition of economic sanctions and consequent facilitation of luxury brand import. Ever since the 1970s, Iran has suffered enormous fines introduced after the Khomeini revolution. Sanctions were renewed in the following decades due to human rights violations and the development of nuclear technology. Furthermore, it is estimated that the average expense per capita on underwear will increase by a considerable margin in the next few years. Until 2016, Iran faced a trade embargo, usually eluded through contraband imports. Despite this, upon the end of the sanctions a great customer pool has developed, fast-growing and including young consumers.
Moreover, the Iranian market was historically linked to Italy and responsive to the Made in Italy mark.
At the moment, small and medium retailers dominate the market but shopping centers are growing exponentially. Such growth is due to the fact that Iranian consumers associate European and US products with a high-quality level.
The fast growth of the underwear market in developing countries is also due to the fact that women are gaining the willpower to show themselves in public, and are expanding their perspectives in terms of acceptance of underwear, dedicating more and more time to its purchase [39].
The Asia Pacific market (China, Japan and South Korea in particular) and the Indian one are the market growing most rapidly. The transition in consumer lifestyle, supported by growing urbanization and buying power, is the main cause of this [36].
The methods Oscalito uses to choose its distributors and retailers are the following:
Product placement, which must be adequate, not only in terms of price (Oscalito products belong to the high-end market), transportation, and customs charges (particularly high outside of Europe), but also in terms of the ability to maintain a product placement that is suitable to the brand image;
Reliability of the distributor in financial terms, in that the Oscalito supply chain is very long, thus a canceled order is a relevant issue for the company.
The ability to describe the product, which must be very strong. The distributors and retailers shall have the skills and motivation to describe the product to the end customer.
The future of distribution within the analyzed industry appears to be organized retail, where the brand is provided to the retailers who each have their loyal brand or pool of brands. Nevertheless, market growth also includes online stores.
The Oscalito brand does not only represent high quality and excellence through slow production, but also represents Made in Italy.
Made in Italy is one of the bestselling global brands and is linked to positive values such as creativity, esthetics, quality, and attention to detail. It has become a synonym of “knowing how to make things well”, and is an added value to our production system: basically, a collective asset [40].
Upon analysis of such data, the Authors may firmly state that the European and US markets have a high level of attractiveness and competitiveness, thus it is worth maintaining corporate presence within such markets.
The problem of counterfeiting and imitation is an issue that starts above all from China, jeopardizing brands image and offering fake products which brands need to be protected from. Every day there are attempts by China to register the brand and, in relation to a particular case in which the Oscalito brand has been filed on non-clothing classes, the company attempted to appeal but the transaction was not successful and further costs would be incurred.
Fighting against powers such as China at a local, or national, level is quite difficult, expensive and disadvantageous.
Traceability obtained thanks to RFId tag is very appreciated abroad but sometimes the market requires other appropriates certifications: it is for this aim that Oscalito has the Italian Identity Certification [41]. which covers the whole supply chain and very soon it will be certified also Tessile & Salute [42] (Textile and Helath).
With reference to the fashion sector, the objective of this chapter was to verify the possibility to guarantee the origin of the production of an Italian family business and the protection against counterfeiting while pursuing and enhancing aspects of the company tradition also linked to the Made in Italy concept. It has been stated [43] that the concept of made in Italy dates back to the 1970s and identifies the Italian garment with “some examples of innovations in design and history that maintain and reinforce the high levels of Italian craftsmanship, attention to detail, beauty, and cultural heritage, the values that define the Italian character and style at its best”. As a kind of loop, the heritage, as well, enhances the [44] contemporary Italian fashion.
Some Scholars express some criticisms about the case study method, as it is not rigorous and, as it is focused only on a single case examination, it is difficult to get a generalizing conclusion. Even if these above-mentioned issues are generally accepted and are definitely critical aspects, the Authors of this chapter trust that through the evaluation of Oscalito case study, they have been capable to describe how innovation, mainly represented by the application of RFId tags, has been capable to guarantee the origin of the production and to ensure the transmission of traditional characteristics of the company.
RFId tags guarantee a full traceability and an extensive control over manufacturing and shipping.
Thanks to the implementation of RFId tags along the supply chain, Oscalito, as a proof of excellence, has earned the Italian Identity certification issued by Italcheck, as well as the “bestseller” award by magazines specialized in underwear.
Other consideration is that this research has been realized during the COVID-19 emergency and, as it is not predictable when it will be solved, most of the above-mentioned thoughts may be reconsidered in light of the ongoing of the global pandemic crises.
Oscalito, during these months, has immediately reinvented itself and decided to contribute to the fight against the Coronavirus by converting some line producing masks. Great quality, despite all the economic damage suffered, even without the necessary aid and due, has succeeded in creating a new product, absolutely innovative, produced designed and packaged entirely in Italy. Also this product has a supply chain with an almost total sustainability and transparency content. These masks are “
This research has undoubtedly some limitation due to the applied method as it has been adopted a qualitative methodology for a single case study. Deeper researches are requested in order to check a general fashion industry trend with reference to the application of RFId technology.
We would like to express our sincere gratitude to the editor and anonymous referees for their insightful and constructive comments and to thank Dr. Dario Casalini (Oscalito) for his helpful advice and suggestions on various issues examined in this chapter.
The Authors have no conflict of interest.
Both Authors contributed equally to the article.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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The incorporation of legumes in diets, especially in developing countries, could play a major role in eradicating protein-energy malnutrition especially in developing Afro-Asian countries. Legumes could be a base for the development of many functional foods to promote human health.",book:{id:"5963",slug:"functional-food-improve-health-through-adequate-food",title:"Functional Food",fullTitle:"Functional Food - Improve Health through Adequate Food"},signatures:"Yvonne Maphosa and Victoria A. 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The main global health organizations have incorporated patient safety in their review of work practices. The data provided by the medical laboratories have a direct impact on patient safety and a fault in any of processes such as strategic, operational and support, could affect it. To provide appreciate and reliable data to the physicians, it is important to emphasize the need to design risk management plan in the laboratory. Failure Mode and Effect Analysis (FMEA) is an efficient technique for error detection and reduction. Technical Committee of the International Organization for Standardization (ISO) licensed a technical specification for medical laboratories suggesting FMEA as a method for prospective risk analysis of high-risk processes. FMEA model helps to identify quality failures, their effects and risks with their reduction/elimination, which depends on severity, probability and detection. 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Leadership in health services is important for following innovations and adapting to current situations. Nurses working together with other health personnel in hospitals providing health services constitute an important group in leadership. Nursing, which is a key force for patient safety and safe care, is a human-centered profession, and therefore leadership is a key skill for nurses at all levels. The leadership styles of nurse managers are believed to be an important determinant of job satisfaction and persistence of nurses. The need for nurses with leadership skills and the need for nurses to develop their leadership skills are increasing day by day. There are several leadership styles defined in nursing literature. These leadership styles are examined under the titles of relational leadership style, transformational leadership, resonant leadership, emotional intelligence leadership, and participatory leadership. The task-focused leadership style is explored under the headings of transactional and autocratic leadership, laissez-faire leadership, and instrumental leadership.",book:{id:"9047",slug:"nursing-new-perspectives",title:"Nursing",fullTitle:"Nursing - New Perspectives"},signatures:"Serpil Çelik Durmuş and Kamile Kırca",authors:null},{id:"58916",title:"Factors Affecting the Attitudes of Women toward Family Planning",slug:"factors-affecting-the-attitudes-of-women-toward-family-planning",totalDownloads:8485,totalCrossrefCites:9,totalDimensionsCites:18,abstract:"Everyone has the right to decide on the number and timing of children without discrimination, violence and oppression, to have the necessary information and facilities for it, to access sexual and reproductive health services at the highest standard. Deficient or incorrect family planning methods, wrong attitudes and behaviors toward the methods and consequent unplanned pregnancies, increased maternal and infant mortality rates are the main health problems in most countries. Individuals’ learning modern family planning methods and having positive attitude for these methods may increase the usage of these methods and contributes the formation of healthy communities. 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Over periods of time, some of these norms become standards that all members of the community are expected to adhere to. Deviance from these standards is seen as absurd, wrong, or frankly abnormal. However, many of these cultural mores have no scientific basis and, some of them actually promote behaviors with negative health consequences. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. 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In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. 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He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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