Ayurveda Concepts of Joint Diseases

Prevalence of bone related diseases are very high in the world today, among them arthritis is very common form of disease suffers millions of people, problematic for individually and economically to the society due to the long term disability. If not properly manage leads to joint replacement surgical procedures which are very common and high in cost. Aim of this chapter to make attention in application of Ayurveda medicine for betterment of the world population. Ayurveda explain theories in origin of these diseases, causative factors, eteopathogenesis and management steps mostly using herbal drug products mentioned in eight divisions of Ayurveda. Main common two diseases sandhigatha vatha correlated with osteoarthritis and amavatha correlated to rheumatoid arthritis well described with proper management procedures with many other bone and joint diseases. Different theories were discussed with the aid of philosophical backgrounds which facilitate these medical theories. These are five element or panchabhutha theory, three dosha concept or theory of three governing energies of the body, saptha dhathu concept or body bearing tissues, concept of agni or metabolic power. Different treatment plans were described as treatment options for cure and prevention of human being as a complete medical system.


Introduction
Millions of people around the world suffer many kinds of bone and joint diseases.It was reported that five million people suffer from osteoarthritis and 12000 of children were from juvenile arthritis.In modern medicine described disorders of connective tissues, joints and bones that cause musculoskeletal pain and stiffness are predominant features [1].Same as in modern medical field Ayurveda medical system also identified the commonest form of joint disease known as sandigatha vatha that correlated to osteoarthritis manifested with pain.
This information described well in history of the Ayurveda medicine included in literature which goes thousands of years back.Ayurveda, define as the science of life coming from ancient to this era as a system of natural way of healing to the world population.This medical system old at least 5000 years which come from time of (1500-1000 BC) but address the health problems appears today and benefited to promote good health and longevity while cure the diseases.When study about the historical background until 700 BC, this science has been orally discussed between sages and physicians [2].There after two main texts were assembled to discuss medicine part by Charaka called Charaka Samhitha [3] and surgery concepts were discussed by Susrutha in his text Susrutha Samhitha [4] later some texts were written and they were included to separate time periods until come to present stage, as pracheena kala (ancient period), madya kala (medieval period) and nuthana kala (modern period).Two Ayurveda authentic texts were available known as Charaka Samhitha which described etiology, symptomatology, pathology, prognosis and management of diseases written by physician Charaka and Susrutha Samhitha deals with surgical instruments and procedures written by surgeon Susrutha.
Ayurveda medical system mainly divided into main 08 branches known as Ashtanga Ayurvea (sub divisions).These divisions correlated to modern medical stream named as shalya thantra (surgary), shalakya thantra (ENT), kayachikithsa (general medicine), bhutha vidya (holistic medicine), agada thantra (toxicology), rasayana thantra (geriatrics), vageekarana therapy (aphrodisiac procedures) [5].All these fields deals with every aspect of theories related to Ayurveda medicine on causative factors of diseases, treatment lines, preventive measures, prognosis, deformities and rehabilitation procedures.Except to these many literature were contributed to the field by ancient Ayurveda scholars including large amount of drugs as sauces from plant kingdom, mineral and animal kingdom among them Bhava Prakasha is one important text which was written in adhunika kala (modern period) [6].Most of these literature described various facts relevant to joint diseases with treatment options in Ayurveda, this chapter also designed to give a view about joint diseases as Ayurveda approach.

Ayurveda concept of health
There are main two objectives of Ayurveda as medical system well explained par with the definition to a healthy person explained by the World Health Organization.Two objectives comprised preventive and curative aspects of living human beings.Ayurveda deals not only with body but also with the mind and spirit as well.In Ayurveda medicine well described the features of a healthy person.Firstly he or she must have three main energies (tridosha) that governing the body in balance state the term which implies samadosha (balanced three doshas) which act as main three pillars to stable the body in healthy state, by involve in body functions.Agni or metabolic power of the body is another factor that needs to be in balance state of a body.Dhathu or tissues seven in number are the components that bare the body of a person as per the Ayurveda view that need to be in balance state to give healthy life.Waste products of the body (mala) also need to be in balance state to appear a person in healthy manner.Except to these physical structures clear mental state as well as balance mind good spiritual soul need in a person to spend a healthy life as described in Ayurveda system of medicine.With these three energies maintain metabolic activities by the agni (metabolic power) help the interactions are processed inside the body constituents based on the theory of panchabhutha (five element theory of Ayurveda).Panchamahabhuthas are the material basis of the universe so as for the living body.The gross body of a living being consist of this five elements and life processes due to consciousness.Par with the philosophical explanations five mahabhuthas (Panchabhutha i.e.Pruthvi, Ap, Thejas, Vayu, and Akasha which correlated to atomic levels of structure that constitute the vegetable, animal and mineral kingdoms) along with consciousness called six dhathus (components) that a human being is comprise [5,6].This is the scientific background that implies in definition of healthy person related to the mind.On combination with consciousness, five elements, out of their some portions, constitute three doshas in order to perform and regulate the physiological process of the body [5,6].The changes in physiological functions can be given rise due these reasons as mal practices of food patterns, behavioral nature of a person environmental, seasonal changes as well as traumatic conditions can be affect to change this balance state of a person and create diseases in the body that make individual mentality unstable.

Ayurveda approach in origin of diseases
According to Ayurveda, most diseases connected with the psychophysiological and pathologic changes in the body are caused by imbalance states in three doshas (ie, vata, pitha and kapha) these three energies which governs the body by maintaining the balance of body constituents and help in homeostasis in internal environment [7].Each energy is responsible for certain type of body functions such as Va t h a (Air/motile force) energy of movements, functions of nucleus, neurological activities, and natural urges stool/urine or gases etc. Pitha dosha (Fire/Agni) is responsible the functions of energy of metabolism, digestion with transformation, functions of mitrochondria, hormonal and enzymatic activities.Third category of energy is the kapha (Water/fluid component) that involves body functions of energy of lubrication structure, functions of protoplasm, secretory activities, and functions of the fluid contents of the body.These three energies govern the body bearing structures as well as functions of those structures.Another factor is tissues (dhatus) that bare the body, that seven in number correlated to the physical structures of the body such as rasa (plasma), raktha (blood), mansa (muscles), medas (fat tissues), asthi (bones), majja (bone marrow) and shukra (sperms/ovum).Three waste excretory products of the body known as mala (stools), mutra (urine) and sweda (sweat).Mainly agni (metabolic/fire) is an important concept describe in Ayurveda which mainly involve as causative factor for diseases, if it is in imbalance or mal function state known as ama (i.e.undigested state of foods in digestive tract which causes diseases/formation due to dearranged agni) which is mainly involved in certain type of joint diseases also.Important 13 agnis are activating in tissues, organs and systems of at different places of the body.Main type is jataragni (digestive power) activate in the digestive tract that correlated to enzymetic actions of gastrointestinal tract.Twelve other agnis (metabolic fire/power) are established in different places of the body and functionally contributed to internal homeostasis.Each tissue levels composed their owned metabolic powers namely dhatwagni 07 in number as rasa dhathvagni, raktha dhathwagni, mansa dhathvagni, medas dhthvagni, asthi dhathvagni, majja dhathvagni, shukra dhathvagni those involves in process of tissue metabolism.There is another important category of metabolic power is activated in micro channels and cellular level of the body named based on five element theory of Ayurveda as panchabhuthagni [8].When these micro metabolic powers are not properly activated at cellular levels micro channels of the body (srothas) will not function properly, they blocked (avarodha) channels and tissues as well as organs then cause diseases.Main other concept of this medical system identified which cause the root for diseases produced ama within the body that can get mixed with doshas and formed complexes named as sama vatha, sama pitha and sama kapha which give rise symptoms of diseases [9].Accoring to Ayurveda concepts ama means unripe substance produced under the weakened state of Agni (digestive power).Features of this ama state are visha (toxic), slimy in nature, has unpleasant odors, heavy in nature and has/represent various colors [9][10][11].
As per the view of this system of medicine development stages of a disease is describes based on five element theory, saptha dhatu and concept of agni described early paragraph.As the body composition and functioning energetic three doshas and the body tissues (dhathus) comprises from similar physical properties, there is relationship between doshas and tissues (dhathus synonym as dushya) in origin of a disease identified as combination these two components and named as dosha dushya sammurchana (combination of vitiated dosha with tissues) according to this combinations demonstrate the symptoms of each disease in process of eatiopathogenesis [12].Categoriztion of idiseses done according to this relationship between these doshas and dhathus (tissues seven in number) known as dosha-dushya complex that can be seen as symptoms in a patient.
Treating the diseases there are different conceptual theoretical background is established in this medical system.Mainly it described remove the causative factors of diseases such as diet, seasonal changes, correction of generating ama are some steps can be practically apply to breaking down the stages of etiopathogenesis and remove the ama by applying relevant medicaments.As an example rheumatoid arthritis which involve not only the joints but also certain other systems also in angle of Ayurveda view that cause when samavata mixed with rasa dhathu then causes Amavatha (rheumatoid arthritis), combination of samapitta and raktha dhathu produces vatarakta disease.Ama is a substance having a toxic nature and this toxic substances reacts with joint and bone elements causing the diseases.If Ama is not produced, there will be no bone joint disease either, this is the theory behind this medical science, that implies it has been mentioned that synonym given for diseases the word ama.

Involvement of Dosha in born and joint diseases in Ayurveda
Born and joint diseases in Ayurveda mentioned with related concepts texts written in ancient to modern period.These information were stated by modern Ayurveda scholars after further study well they mentioned that three main joint manifestations were identified and treated.They are Sandigatha Vatha (osteo arthritis), Amavatha (rheumatoid arthritis) and kostukashirsha (pain with swelling of knee joint) [9] symptoms of these conditions can correlate to structural changes of modern clinical cases.Two of them are polyarthritic clinical entities having a range from acute to chronic.Sandhigata vatha is the commonest form of articular disorder.It is a type of disease which mainly occurs in oild age people due to the dryness of the tissues which limits daily activities such as walking, dressing, bathing making patient disabled.Because this is a type of vatha category of disease can be lead to dangerous if located in a vital point, same situation occurs in an old person difficult in cure.Therefore in identifying prognosis by detect early symptoms is very important because this is very common type of disease.As it is vatha type of disease shula (pain) is the cardinal feature of the disease associated with sandhishotha (swelling), lack of movements of the joints or painful movement of the joints, sometimes loss of function and dislocations are possible.Vatha raktha is a condition give rise symptoms of pain, fasciculations, swelling, dryness of the affected part with discoloration, itching, contraction are seen, predominantly in larger joints, but begins from the smaller joints both the vatha (motile force) and raktha (blood) are in predominant positions.This condition influenced by ama combined with pitha dosha that known as sama pitha and manifest the symptoms accordingly.Kostukashirsha is the other common form of disease naming according to its appearance of the knee joint after affected knee joint of the person known jackals head due to the swelling and same time person feels sever pain.
Modern period literature described the relationship between ama and joint disease to give a better diagnostic outlook.Rheumatoid arthritis which is a whole multitude of joint manifestations that given rise to joint malfunctioning disease correlated to Amavata decribed in Ayurveda [13].Ayurveda diagnosis can be done only study the dosha involvement, causative factors, symptoms,malfunctioning of the affected part and finally can be treat using herbal drugs use in the field with the help of Ayurveda pharmacodynamic properties with the aid of drug actions [14].
Ayurveda Concepts of Joint Diseases DOI: http://dx.doi.org/10.5772/intechopen.99384 When considering structure-function relationship and dosha involvement need to mention the five verities of three doshas vatha, pitha and kapha is very important.There are 5 varities of three doshas which were located at specific places of the body and give its contribution to the proper functions of that area of the body [15,16] were well described in Ayurveda texts and that types are tabulated in Table 1.
Each and every type of dosha located at its own site facilitate its action to that relevant body parts.These types of each dosha is well responsible to cover all the functions of the body, when consider the structure and functions of the joints (sandhi) Shleshaka kapha component is the main part that give the actions related to its structure in the locomotive system [15,16].
Sandi samslesha (bindings of joint) is described as one of the functions of kapha that described in Ayurveda view.Susrutha postulates similar views and while describing the functions of kapha, mentions of Sandisamshleshanam (lubrication of the joint), snehana (promotion of uncouthness), purana (storage or filling), stayikrit (stability) which are directly connected properties pertaining to sandhis (joints).The text written in pracheena kala Ashtangahrida samhitha mentioned that among other functions shleshma promotes, sthirathwa (sturdily), snighdhatwa (viscosity) as well as hates (binding) actions that are specifically applied to joints.Keeping various components of it in firm unity that makes it possible to function as a single unit, further shleshaka kapha protects it's articulation and opposes any force that might cause it's separation and disunion.According to the literature it becomes clear that Shleshaka kapha is predominant in joints and keeps them well lubricated and nourished.These explanations correlated with structure (including synovial fluid) and functions to integrate as medical systems were mentioned in this paragraph.
In the disease state of sandhis (joints) one or more above functions seen to be deviate it's normal in functioning due to the pathological changes and give person abnormal feeling.The bone ends are covered by hyaline cartilage, avascular tissue which provides a smooth, low friction surface allowing joint movement.Normal articular cartilage is a smooth bluish translucent material which is composed of chondrocytes, proteoglycans, collagens and water that correlated to structure and functions of Shleshaka kapha variety explain in Ayurveda.It is very important to identify the bone and joint related diseases with proper classification of these in Ayurveda by integrating its application for treatment options due to high prevalence of these disease conditions.Disorders of the joints are among the most disabling of conditions.They cause serious morbidity to the affected individual same way major economic importance to both the patients and society [15][16][17][18].

Types of bone and joint diseases in Ayurveda
In this chapter mainly discuss about the joint diseases, Ayurveda literature mostly discuss about three joint related diseases such as Vatha raktha, Sandigatha vatha and Kostukashirsha but except to these in different texts written from ancient time to modern period discussed other bone related diseases and joint diseases.They have named according to the structural manifestation, dosha involvement, place that symptoms, structural changes can be seen, relevant to its tissues that mainly affected.They are Sandigatha vatha (it is a vatha dosha category of condition that pain is the main feature of this, which mainly occurs in old age due to dhatukshaya or dryness of the tissues, which limits everyday activities such as walking, dressing, bathing making patient disabled), Vata raktha (swelling, dryness of the affected part with discoloration, itching, contraction are seen, predominantly in larger joints), Kostuka shirsha (pain and swelling in the knee joint), Avabahuka (pain with restriction in movements of the upper arm), Vatakantaka (pain at calcanium area), Grudrasi (pain along the hip joint and thigh that causes difficulty in walking, pain is the main symptom), Khalli (loss of function and paralysis, specifically affecting the leg), Urustambha (severe pain, loss of function and loss of temperature sense in the affected limb), Hanusthamba (mainly due to trauma, dislocation of tempero mandibular joints, loss of movement is seen), Asthimajjagata vatha (severe crushing pain in bones and joints, discolorations are possible, loss of muscular power and strength with gradual thining of the affected limb), Visvachee (loss of function of the hand due to the dryness of structures at wrist joint which cause pain that radiates from the proximal to distal hand), Amavatha (mainly affects bigger joints, appears symptoms of anorexis, vomiting, malaise, indigestion), Raktha vatha(cause due to vitiation of rakta dhatu, slightly similar to Vata rakta in its clinical presentation), Visha vatha (cause due to infections), Jara vatha (cause due to old age, this included to natural bony degeneration due to senility), Jirna vatha (manifest due to degenerative processes), Pada bransha (characterized by loss of function of the affected foot among the eighty types of vatha rogas), Vatha khuddatha (one among the eighty types of vata rogas), Gulpha graha (stiffness in the ankle joint is the predominant feature), Uru sara (severe pain, loss of function and loss of temperature sense in the affected limb), Janubheda (type of pain localized in the knee joint), Pangulya (person felt to limp a sign due to any causes, such as trauma, dosha), Thrika graha (stiffness at the macro iliac joints), Prushta graha (stiffness in the spine), Bahu shosha (wasting is the predominant sign in this condition, at the shoulder), Griva sthambha (Stiffness in the neck), Asthyavrutha vatha (Obstruction of vatha due to asthi dhatu causes penetrating pain, stabbing pain and lassitude), Kaphavrutha vatha (Vyana vatha is being obstructed by kapha dosha, pain felt at the small joints and the patient feels heaviness in the body) [17,19,20].
When observe these different types of bone joint diseases discussed in Ayurveda texts it shows some are appear as vatha category of diseases, some are causes due to traumatic conditions and involve the bones or joints.Therefore some scholars who were searched for these in modern period looked into that and categorized into certain classifications.They mentioned three disease conditions namely Sandigatha Vatha, Vatha raktha and Kostukashirsha were the mostly discussed disease conditions in literature, also these conditions common in clinical practice [21], therefore clearly mentioned involvement of dosha, causative factors, prognosis and deformities prominent diseases, then classification explained accordingly as mentioned here.
Rheumatoid arthritis is a critical disease condition which the person is highly disabled if it is not properly managed.In Ayurveda system of medicine this disease well described in modern period texts that correlated to name as Amavatha which is a disease that systemic involvement as well as local involvement can be seen in large joints.It mainly affect bigger joints, presenting symptoms of anorexia, vomiting, malaise, indigestion etc. causative factor is due to the malfunction of digestive power.In the patients it presenting swelling with predominant pain as the symptoms with many other complaints.In ancient literature term 'Ama' the word Ayurveda Concepts of Joint Diseases DOI: http://dx.doi.org/10.5772/intechopen.99384comprises Amavatha used to denote a state of illness cause 'visha' padartha (toxic matter) which produces due to malfunction of digestive power.Also malfunction of the metabolism of the body benefited this disease process.Texts and the scholars of modern period of Ayurveda history described views about arthritis or joint diseases by indicating variety of clinical presentations.They stipulated the possibility of occurs several interrelated entities with possibly different etiologies related to joint diseases as mention here.They are Rasa Vata (a synonym for Amavatha), Raktha Vatha (a similar condition to Vatha raktha in ancient texts), Visha vatha (a condition similar to acute infective arthritis in modern medicine), Jirna vatha a condition with sandhi jadya or ankylosis due to old age, Jara vatha similar to degenerative arthrosis, Sandhika jwara to rheumatic fever.Same manner Amawatha correlated with its symptoms to Rheumatoid arthritis and according to the causative factors and disease involvement different treatment measures were prescribed such as to correct the digestive power and digest the ama and facilitate to absorb to the system, and then avoid the manifest in the locomotive system.Different treatment measures were described for this to manage the disease process help of drug actions such as deeepana (appetizer), pachana (digestive) drugs, local treatments according to the involvement of joints external drug preparations are applied to relieve pain and swelling with improve the joint movements.

Classification of bone and joint diseases
Based on the clinical features these diseases classified according to the causative factors, involving places, and symptoms by compairing structurural and functioning features in modern medicine [1,17,19], manifest in diseased person which is important in treating and management of bone and joint diseases, par with Ayurveda treatment plans, here it has been mentioned according to the based on or predominance of each factor.

Based on toxic factor
Visha vatha.

Ayurveda treatment options for bone and joint diseases
To manage these diseases different therapeutic measures are used according to the Ayurveda system of medicine.In clinical practice medicinal materials in form of single drugs as well as poly-herbal formula are used.Body has been buildup of dietetic materials, the drug materials giving to manage the diseases also constituted same physical properties identified by Ayurveda influence of philosophical literature, also the aid of these theoretical concepts drugs are prescribed based on their actions.Body treatment is correlated to management process of a disease in Ayurveda defined as chikithsa which has a broad meaning related with the body.Literary meaning of body, described based on philosophical backgrounds that stated body derives and develop from nutrient materials and it is a collection of nutrients.To maintain its balance status there should be equilibrium in metabolic functions.These functions are governing by the three energy flows (vatha, pitha, Ayurveda Concepts of Joint Diseases DOI: http://dx.doi.org/10.5772/intechopen.99384kapha) with the help of different agnis (metabolic power) in the body.These processes activate in the body and responsible to maintain the internal environment in balance state by avoiding cause any imbalance which originated a disease.Therefore treatment defined as chikithsa that implies collection of suitable procedures which can be normalizing the imbalance state of internal environment of the body.
Collectively these procedures lead to promoting and preservation of health in healthy person and curing disease in the sick person which highlights curative, preservative, rehabilitative and preventive aspects to manage diseases which in same manner applied to the joint diseases.Based on theoretical aspects different treatment lines are applied to manage joint diseases.They are avoiding causative factors such as dietary mal practices, mal practices in behavior, correct expose to seasonal changes.Pacifying visited doshas mainly vatha samana using drugs pertain drug action of vedana stapana to relieve pain with other medicaments for correct rearranged body functions according to the causative factors [14,21,22].Excretion of disease causative factor known as ama by digestion of ama into the system using suitable drugs.Cleansing the obstructed channels (srothas) by five bio purificatory process known as Panchakarma using suitable drugs [23].Facilitate diseased person if the condition caused due to the aging process by rasayana (rejuanation) therapy which is a main branch of Ayurveda.Whether person needs the rehabilitation yoga therapy or meditation can be advice to the patient.Finally all these treatment options can be apply as local or systemic therapeutic applications according to the patient condition as well as the nature of the disease.

Conclusions
Three energies governing the body functions to maintain the balance state of internal body environment.Vatha dosha as motile force and neurological activities.Pitha dosha responsible for metabolic, enzymatic and hormonal actions.Kapha dosha represents fluid component and its actions.Common form of joint diseases are osteo arthritis and rheumatoid arthritis respectively correlated to sandhigatha vatha and amavatha, for management these conditions herbal products, body purificatory processes, rejuanation procedures with yoga exercises can be used as therapeutic options.

Table 1 .
Categories of three Doshas.