Teaching Balanced Patient Care Using Principles of Reductionism and Holism: The Example of Chronic Low Back Pain

This chapter explores how integrating holistic and reductionistic approaches to care may better optimize value based care. First, we define the terms ‘Holistic,’ ‘Reductionistic’ and ‘Integrative’. Then we explore their scope in the arenas of teaching and patient care, with the advantages, disadvantages and pitfalls of each approach. We review how these styles are embedded in and interact with the cultures of medicine and western societies at large. As an example of a balanced care approach, we focus on the example of chronic low back pain (CLBP), an increas-ingly common and expensive medical problem. We present practical examples of teaching and practicing these different styles, Holism and Reductionism, illustrating when each may be appropriate to optimize value of patient care. Study questions are included. A list of further readings and resources is included for the interested reader.


Introduction
Present U.S. graduate medical education (GME) teaches knowledge, skills and attitudes to future providers in a health care system that spends a higher % of GDP with often poorer outcomes for chronic disease care than most other industrialized nations [1,2]. Much of the chronic disease burden is driven by preventable risk factors such as poor diet and exercise patterns and risky behaviors such as substance abuse [3,4]. This unsustainability is driving rapid transition to value based care, with payers demanding better outcomes for their dollars spent. Given the unsustainability and suboptimal effectiveness of our present chronic disease care, we might ask how GME needs to change in order to deliver more effective, value based care. This chapter explores how integrating holistic and reductionistic approaches to care may better optimize value based care, using as an example the dilemmas surrounding treatment of chronic low back pain (CLBP). Such integrative care may also lead to better physician satisfaction and less burn-out, as discussed later in this chapter.
1. An implicit assumption of reductionism is that correcting the part will enhance wholeness. That is, that we have enough understanding of how the part relates to the whole that we can safely and effectively manipulate it to improve wholeness or health.
2. Implied in the practical application of reductionism (e.g. the use of many pharmaceuticals) is the assumption that treating symptoms of a disease is a reasonable surrogate to healing the whole person.
3. Concepts and fields of inquiry that are emphasized in a reductionistic approach to medicine focus on analysis of body structure and function, such as anatomy and physiology, and methods of manipulating these, such as with surgery or pharmaceuticals. 4. Evaluating and treating a 'part' can have many advantages. It is often more practical, expedient and parsimonious in its use of health care resources. For example, an inflamed appendix is diagnosed as the proximate cause of acute abdominal pain with a CT scan and surgically removed, or a fractured hip is diagnosed by X-ray as the proximate cause of acute hip pain and pinned. Most would agree that this 'fix it' approach makes eminent sense in these acute cases and leads to a better health outcome for these patients.
5. Our healthcare system is largely built on this reductionistic paradigm. In this paradigm, focus is on disease treatment, not wellness. The characteristic of the patient that has the disease is much less important. For example, diabetes mellitus type 2 (DM2) or chronic low back pain (CLBP) is treated more or less the same regardless of which patient has it. Likewise, 'providers' are largely interchangeable, since care algorithms are tailored to the disease rather than the patient or the patient-physician relationship. The health of the relationship between a patient and their physician is given much less importance. In these and other chronic diseases, the same approach used in acute care of treating the simple proximate cause is often taken. For example, an easily measured proximate cause of microvascular complications in DM2 is hyperglycemia, so focus is often on treating this with pharmaceuticals that lower blood sugar. While certainly worthwhile as part of a therapeutic strategy, when hyperglycemia treatment is done to the exclusion of a large number of other issues in DM2, sub-optimal outcomes may result. Examples of less easily measurable issues in DM2 include addressing habituation to highly processed 'pseudo-food' such as snacks that have manipulated fat, salt & sugar content [5], correcting the body's gut microbiome (which is altered in DM2 [6], improving vascular compliance and possibly autonomic balance [7,8], calming chronic inflammation, reversing DOI: http://dx.doi.org /10.5772/intechopen.82618 hepatic metabolic derangements related to steatosis, improving insulin sensitivity [9], decreasing excess load of advanced glycation end products [10,11] and many other less easily measurable but important aspects of DM2 treatment. Less attention to these other important factors may be one reason that present DM2 treatment algorithms have suboptimal outcomes, for example with macrovascular disease. Advice to eat right and exercise is commonly given, but very little resources or time is devoted to helping the patient actually accomplish these profound lifestyle changes in most DM2 care algorithms. Most doctors have very little training in nutrition or exercise science and thus may feel less qualified to guide the patient in these areas. A care model focusing on individual office visits is unlikely to allow delivery of the depth of lifestyle guidance actually required for significant change. If quality of care is narrowly defined by if glycemic goals are met, providers will focus on meeting this metric. 6. Many providers and patients perceive the overall approach of our present healthcare system as problematic, expressing concerns about 'hamster wheel medicine'-attempts to treat complex issues in 15 minute slots, over focus on treating symptoms rather than underlying cause, dissatisfied patients, epidemic levels of provider burn-out and soaring health expenditures as unintended consequences of our present Healthcare model. 7. The development of reductionist approaches to medical care, with its underpinning of largely reductionistic scientific methods, has led to enormous advances. This is especially true in the areas of acute care, such as emergency medicine, critical care medicine and surgery. However, serious limitations become apparent when this same reductionistic paradigm is applied to chronic disease. The major modifiable factors driving chronic diseases, such as obesity, diabetes mellitus type 2, chronic obstructive pulmonary disease (COPD), heart disease, depression and chronic pain are related to lifestyle and/or environmental influences. Outcome studies in general show sub-optimal results when reductionistic methods, such as an over-focus on pharmaceuticals are applied to many chronic diseases. Our present reductionistic models seem impotent when faced with the rising tide of obesity, DM, depression and chronic pain. A new paradigm is needed.

Holism
Holism: a style of perception, teaching and practice of medicine based on the axiom that the whole is irreducible and cannot be adequately understood by simply understanding the parts. MeSH Scope defines "Holistic Health" as "Health as viewed from the perspective that humans function as complete, integrated units rather than as aggregates of separate parts." 1. The implicit assumption of a holistic approach to care is that enhancing wholeness will lead to healing of any dysfunctional parts that are manifesting as disorder or disease. This also assumes that it is within the power of the patient (with the facilitation of the healer) to enhance this restoration toward wholeness.
2. 'Wholeness' implies balance and integrity within the patient and in their relationships. For example, a person is more 'whole' if they not only have less disease symptoms, but also have maintained a sense of internal emotional integrity, life meaning, and family and social relationships.
3. The focus of holistic approaches to patient care are on overall wellness as relates to the presenting disorder of the patient, including healthy lifestyle aspects such as healthy eating, movement (exercise), rest & sleep, personal and social relationships and relationships to a higher power or intelligence.
4. Concepts and fields of inquiry that are emphasized in holistic healing include whole food plant-based approaches to eating, meditative movement to support mind/body harmony and insightful emotional processing leading to emotional/energy balance, supportive relationships, including at inter-personal, family and community levels, cultural and socioeconomic justice, environmental health and spiritual relationship.

5.
The assumption that 'healing the whole will heal the part' implies placing the locus of control more on the patient than the physician. The healer is more of a 'facilitator' rather than someone who 'fixes' the patient. This fundamentally changes and makes paramount the relationship between physician and patient, and places more importance on adequate time for this relationship to develop and be maintained. It also implies that the characteristics of the patient that has the disease are equally or more important than the particulars of the disease the patient has.
6. Skill sets emphasized in holistic care include the following: a. intuitive and emotional perception and processing b. developing skills in listening, understanding and communication c. ability to sense and find balance and harmony

Integrative care
Integrative care for the purpose of this chapter means an approach that attempts to balance reductionistic and holistic approaches to medical care and healing to  optimize patient outcomes. Concepts and fields of inquiry that are emphasized in integrative care include complexity and systems theory, mind/body integration related fields such as psychoneuroimmunology and an expanded biopsychosocial model that emphasizes supporting a healthy lifestyle in all its aspects. An integrative approach to care may be beneficial not only for patients but also for the physician. Integrative approaches support in depth, meaningful relationships between physician and patient and adequate time to develop these relationships, which may reduce burn-out [12] (Figure 1).

Balancing reductionistic with holistic aspects of care
Metaphorically, reductionism is akin to viewing electromagnetic energy such as light as a particle, holism to viewing light as a wave. Each apparently contradictory viewpoint may have validity and usefulness in different contexts. Choosing the right approach based on the needs of the situation is the goal of an integrative approach in order to optimize value based patient care. All systems of care have holistic and reductionistic aspects, though one aspect may be more emphasized. The biopsychosocial model used in primary care in Westernized medicine is more on the holistic side of the spectrum, while procedural and surgical techniques are more on the reductionistic side. Compared to many indigenous healing systems such as Traditional Chinese and Ayurvedic medicine however, Western conventional medicine tends toward a more reductionistic approach. We may be going thru a stage of necessary re-balancing, with more emphasis on holistic aspects such as lifestyle medicine. However, this attempt to combine these two approaches presents its own set of new challenges.

Simplistic, categorical descriptions of healing systems as 'reductionistic' or 'holistic' should be avoided
All healing systems have reductionistic and holistic aspects. The practice of prescribing many supplements by some 'alternative medicine' practitioners is highly reductionistic, while a 'conventional' medical doctor empathically listening to a patient's illness story is more holistic.

Categorizing conventional medicine as 'scientific', while less familiar healing systems as 'unscientific' is not helpful
This is often used to imply that only Western conventional medicine has 'validity' . All healing systems are embedded in and reflect the culture they exist in, with all that culture's strengths, limitations, blind spots and implicit assumptions. Evidence based medicine teaches us that only about 18% of conventional primary care medical practice has strong scientific support [13]. Other healing systems also have a mix of scientific and more empirical support. Thus it is not reasonable to assert a simplistic dichotomy of conventional medicine as 'scientific' and other healing systems as 'non-scientific' [14].

Assuming one can take a healing modality out of context of the original healing system it was used in and have similar efficacy can be problematic
An example of taking a healing modality out of context is acupuncture. While acupuncture may be useful as a 'stand alone modality,' it is quite possible that its effects in the larger context of Traditional Chinese medicine where it originated may be quite different.

Conflating limitations in scientific methodology for lack of validity of holistic systems
While outcome studies can assess a holistic care modality in its entirety, there are severe limitations in our present scientific methodology needed to understand whole systems in general. This lack of scientific methodology does not necessarily mean lack of validity, anymore than a lack of perspective of a person on the face of the earth means the earth is flat rather than spherical.
Conversely, the lack of a deep theoretical framework to understand holistic systems also means that their efficacy should not just be assumed. All holistic systems of care need extensive outcome studies to demonstrate efficacy.
Use of sham therapy in studies for holistic treatments (e.g. osteopathic manipulation, acupuncture, yoga) does not take into consideration the possible benefits of sham therapy, and studies showing equivocal outcomes may falsely imply the benefits of these treatments are due to placebo effects [15,16].

Confusing the immeasurable with the invalid
Present research techniques emphasize quantitative approaches of what is scientifically easily measurable. While this is practical and important, it does not imply that qualitative, experiential and other approaches assessing intangible factors are less valid. Over-reliance on quantitative approaches to research is itself a distorted lens of perceiving reality. Over-reliance on measurable parameters while discounting intangible factors in healing can lead to a 'tyranny of the measurable' .
Relationship between therapist and client appear to be one of the most important aspects of outcome in psychotherapy, rather than the training or type of therapy used, even though these are more measurable than the intangibles of relationship.

Making conclusions on whole systems based on highly reductionistic scientific studies of a part of these systems
Scientific studies of single nutrients are often not relevant to the effects of whole foods. For example, studies on the effects of megadoses of synthetic vitamin E do little to inform us of the effects of whole foods that contain vitamin E [17]. Similarly, nutrients can have widely varying and sometimes opposite effects depending on whether the research subject is deficient or not in the nutrient. Treating nutrients as if they are pharmaceuticals, either in research or in clinical practice, often leads to spurious results and confusion.

Assuming scientific studies on efficacy or side effects in an acute care setting apply to a chronic disease care setting
Studies showing efficacy of opioids in acute pain were assumed to apply to chronic pain, a very different situation, with sometimes disastrous results including contributing to the opioid epidemic [18,19]. Similarly, the multiple side effects and disadvantages to chronic proton pump inhibitors use were not appreciated or understood by studies demonstrating their short term efficacy.

Basing conclusions on studies limited in scope to one culture
Cross cultural nutrition studies show much more significant and often dramatic effects of dietary patterns on chronic disease compared to comparisons of dietary patterns confined to Western societies, because the variation in eating styles in other cultures are sometimes much wider than in Western cultures. Confining nutrition research to Western eating habits can lead to a myopic view [11].

Confusing surrogate biomarkers for the disorder, and hence mistaking correction of the surrogate biomarker for healing
High blood pressure is an important index measure but only one aspect of hypertension, whose pathophysiology includes decreased arterial compliance, altered sympathetic -parasympathetic balance and other pathophysiological issues. Lowering blood pressure, while important per se, is only a partial correction of the pathophysiology of hypertension [20]. While lifestyle issues such as healthy diet, stress management and rest are usually mentioned, they are often given less than necessary attention. Similarly, as stated previously, hyperglycemia is an important index measure but not equivalent to diabetes. An overly pharmaceutical centered approach does little to address the underlying metabolic derangements of DM2.

Assuming symptom suppression is equivalent to healing
Proton pump inhibitors (PPIs) suppress acidity of gastric reflux, but do little to reduce the reflux itself or to address its underlying causes, which is often related to poor diet or eating habits, and expose the patient to a number of increase risks [21][22][23][24].

Underestimating the resources needed for holistic healing modalities
Many lifestyle changes and holistic care modalities require the patient to invest extensive time, attention and sustained effort. Unrealistic expectations of quick change are unfair and demoralizing for the patient and a set-up for failure. For example, changing eating habits likely requires extensive education, social support and reinforcement over many months. It is unrealistic to just tell a patient to 'eat more healthy' and expect much change.

Assuming that supplements, botanical medicines or natural modalities are safer and superior (or more dangerous and inferior) to pharmaceuticals
Such wide generalizations are neither prudent nor supported by evidence. Practitioners tend to view what they are familiar with as safer and more efficacious than less familiar approaches. Thus, conventional medicine oriented practitioners may categorize natural medicines as inferior and 'unscientific' , while holistic oriented practitioners may assume that natural medicines must be better than pharmaceuticals. While many common natural supplements and botanicals appear relatively safe, there is no intrinsic reason that they should be worse or better than pharmaceuticals. For example, anti-HIV medications have no equivalent among botanicals and are clearly life-saving. Gut-directed hypnotherapy and enteric coated peppermint oil are efficacious and safe for certain irritable bowel syndrome symptoms [25,26]. NSAIDs when used chronically have significant and often under-appreciated toxicity. Some commonly used botanicals can be hazardous if not formulated correctly. Kava kava, for example, should only be used in aqueous formulations, since alcohol extracts may lead to liver toxicity [27]. Similarly, while many botanicals can be used safely with many pharmaceuticals, on occasion clinically significant interactions can occur between them. It behooves the practitioner to be aware of these interactions (can access standard references such as Natural Medicines Database) or to consult a qualified integrative medicine practitioner when needed.

Teaching balanced care using principles of reductionism and holism:
the example of chronic low back pain (CLBP)

Chronic pain background
Chronic pain, and in particular chronic low back pain (non-cancer related) is chosen to illustrate an integrative model described herein because of its large burden of suffering and difficulties in treatment with present models of care. Chronic pain in general has an enormous influence on the emotional, physical and social function of patients and society at large and effects about 100 million people in the US alone [28,29].

Approaches to CLBP
CLBP has a wide range of causes that may benefit from different approaches. Some cases appear caused by specific anatomic derangements such as a herniated disc pressing on a nerve root-the 'nociceptive generator' , which lend themselves to a 'fix it' reductionistic approach such as epidural injections or surgery. More general approaches such as physical therapy to build core strength and control can be helpful in many cases of CLBP. Muscle tightness per se can be a nociceptive generator and will often benefit from mind/body and physical therapy approaches. However, in many cases, a specific lesion is not identifiable, and there appear to be significant psychosocial factors related to how the patient experiences pain. Statistically, the biggest predictor of chronic pain, including CLBP, is the 'emotional charge' surrounding the disorder-mood, meaning of the pain in the patient's life, psychosocial consequences. Neuro-anatomic imaging of the spine (such as MRI) has variable correlation to severity and duration of chronic low back pain [30,31]. The challenge for the GME teacher is to teach ability to discern these widely varying etiologic factors and to apply the most effective approach in each case. The efficacy of a sample of widely varying approaches is illustrated below.

Challenges
Chronic pain including CLBP is a highly subjective experience influenced by biological, psychological, and social factors. Alterations in central and peripheral nervous system processes add to its complexity and challenge [32]. Sleep disturbance, anxiety, and depression often accompany chronic pain [33]. These in turn may exacerbate the pain and further reduce quality of life [34]. For example, anxiety and sleep disturbance each occur in about half of people with chronic pain [35]. Depression has been linked with an increase in pain severity in 21-72% of cases [36]. The challenges of chronic pain are exemplified by returning war veterans from tours in Iraq and Afghanistan. Almost half have chronic pain [37], most which is musculoskeletal related [38]. Prevalent among military veterans is their high incidence of comorbid post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI), which likely aggravate their chronic pain syndromes [39].

Reductionist approaches
Reductionist treatments include pharmaceuticals and interventional treatments. Pharmacological treatment of chronic back pain does not correct the underlying cause of back pain, but instead focuses on reduction of pain allowing improvement of functionality. Interventional treatment includes nerve blocks, injections at various points (e.g. trigger point, epidural and facet joint injections), nerve ablations, or surgery. The efficacy of these various treatments is highly dependent on the etiology of the pain.

Pharmaceuticals
Pharmaceutical treatments for CLBP provide relief of symptoms, decreasing pain and improving function. However, pharmaceutical interventions in isolation do not address the origin of pain. Correcting the pathology causing pain is better accomplished with exercise, physical therapy, or spinal manipulation. Pharmaceuticals provide a supporting role in helping patients tolerate pain that may result from some of these treatments. Studies show that medication plus exercise based therapy, performs better than either in isolation [40].
Additional consideration must be given to possible side effects when prescribing medications. NSAIDs are the first line pharmaceutical treatment recommended, while tramadol and duloxetine are second line treatment options [40]. The use of opiates for treating chronic non-cancer pain including CLBP is highly problematic, with strong evidence of harm and growing evidence they are no better than nonopioid analgesics for many chronic pain syndromes, including CLBP [19].

Interventional
In cases where the etiology of back pain can be determined, treatments can be specifically targeted. Radiofrequency ablation targets sources of pain at specific anatomic sites, as determined by a diagnostic nerve block. Systematic reviews of the technique showed significant reduction in back pain over an extended period in some cases [41], however a large RCT showed radiofrequency ablation combined with exercise provided no benefit over exercise alone [42].
Surgical discectomy is superior to conservative management in the treatment of lumbar disc prolapse [43], however this treatment would not be beneficial in cases of lumbar strain. A less obvious difference in treatment outcomes can be seen with transforaminal epidural steroid injections. A review article found good evidence to support transforaminal epidural injections (steroid + local anesthetic) in cases of radiculitis secondary to disc herniation, but there was insufficient evidence in cases of less specific axial pain and post surgery syndrome [44].

Holistic approaches
Even in patients who have not suffered war or other physical trauma, trying emotional experiences such as interpersonal conflicts, work stress, and social rejection can strongly influence the experience of chronic pain [45,46]. These include unresolved struggles with family members, conflicts over perfectionism, stigmatized desires that lead to shame, ambivalence toward one's children, and various other drivers of stress reactions. The main pathological process in both unresolved emotional trauma and internal conflict may be the evasion or concealment of emotions, which are believed to activate neural pathways that augment pain and other symptoms. Focusing on resolving these unprocessed emotions related to unresolved emotional trauma, conflict, and relational disturbances often improves chronic pain. This applies to a wide range of chronic pain syndromes including musculoskeletal pain such as CLBP, fibromyalgia, headaches, irritable bowel syndrome, and chronic pelvic pain [46][47][48][49]. Figure 2 illustrates one possible model to address these issues.

Mind-body integration
In cases of nonspecific back pain, it is not possible to identify a specific nociceptive generator leading to pain. In these situations, a holistic treatment approach to the whole person instead of a lesion may be preferable. Studies have shown various holistic treatments to provide significant outcome. The MORE study evaluated the effect of mindfulness training, cognitive reappraisal, and positive emotion regulatory strategies as a combined treatment in patients with chronic pain who were taking opiates. Early results showed the combination treatment group had lower pain severity, less functional interference, and less desire for opioids compared to the standard support group treatment [51].

Exercise/rehabilitation
Exercise and yoga have been proven to be effective treatments for CLBP. GME should not only focus on teaching about the EBM supporting these treatments, but also teach about regional resources that are available to patients.

Figure 2.
A sample of intervention technique focused on the mind-body model [50]. This model explains how chronic pain due to neural pathways formed by prior maladaptive learning and maintained by emotional avoidance can be "unlearned" with powerful corrective emotional experiences. A systematic review examined a holistic treatment approach to chronic back pain. Multidisciplinary biopsychosocial rehabilitation (MBR) involves a combination of physical, psychological, and educational treatments usually provided by a multidisciplinary care team for the treatment of chronic back pain. The review found that MBR had moderate improvements in short and long term (1-2 years) pain intensity as well as disability compared to usual care. MBR also outperformed physical interventions (e.g. physiotherapy, exercise) in short term pain reduction, as well as short-and long-term disability. Patients receiving MBR were also twice as likely to be working after 1 year compared to physical interventions [52]. Integrating MBR into GME could be easily accomplished by having residents serve as part of the care team for select patients with uncontrolled back pain. Sample schematic on approach to chronic pain and in particular CLBP that integrates both reductionistic 'fix it' and more holistic general support approaches.

Energy medicine treatments
Acupuncture is recommended as a first line treatment option for CLBP [40]; however its basis on an unfamiliar Eastern paradigm involving energy meridians may cause some skepticism among conventional medicine doctors. Research shows that acupuncture therapy produces measurable physiologic effects [53], and randomized controlled trials demonstrate moderate improvement in function and pain reduction. Comparisons to sham acupuncture have had mixed results, but meta-analyses show small improvement. A Cochrane review of 35 RCTs of moderate quality, showed moderate lower pain & improved function vs. no acupuncture. When comparing acupuncture to other treatment modalities, there is again some inconsistency. Low quality studies showed small improvement in pain and function compared to various medications such as NSAIDs. When combined with usual care however, acupuncture and usual care outperformed usual care alone [54]. A sample schematic integrating reductionistic and holistic approaches to CLBP is noted in (Figure 3).

Teaching competencies
Given the widely variant causes of chronic pain, including CLBP, (as well as the causes of many other chronic disease entities), the next question is, how would the GME teacher approach teaching competencies in such a wide range of skill sets? Literature searches on the topic identified articles about teaching holism and wellness to medical students for the purpose of self care. However, there was sparse literature available focused on GME approaches to teaching application of general holistic care for treating patients.
Based on the author's experience, a few examples of general principles in GME teaching of reductionistic and holistic approaches to care of chronic disease are offered below. Some of these are obvious, others not so much:

Teach basic precepts of reductionistic approaches
Thorough and precise theoretical framework of body structure and function, and knowledge of and identification of specific disorders is key to successful specific treatments. Any interventional procedure skill requires ample well supervised hands on practice.

Teach basic precepts of holistic approaches
Teach a theoretical framework of mind/body unity, including evidence base of such fields as psychoneuroimmunology and meditative movement therapies.
Self-regulation of affect and soma can lead to less pain and better function. Skill sets that support this process include: 1. Mindful awareness of and resolution of intra-and inter-personal unconscious and conflictual emotional processes (as exemplified in the above mind/body model) 2. Development of 'kinesthetic intelligence'-awareness and interpretation of the body's 'language' of movement patterns and holding neuromuscular tension and postures. Understand how this correlates with emotional states and musculoskeletal pain syndromes. This also requires 'hands on' experiential 13 practice, for example thru lessons in one of the mind/body practices such as Tai chi, Yoga, Feldenkrais or Somatics.
We suggest that much work is needed in GME education of both the reductionistic as well as the holistic skill sets listed above. Identification of teachers who can guide learners in these skill sets acquisition is important.
Any interventional procedure skill requires ample well supervised hands on practice.

Approaches and modalities in caring for CLBP patients (and patients in general of course) should be guided mainly by the needs of the patient
A common tendency for us providers is to perceive the patient's disorder and needs thru the lens of our own experience and professional scope of knowledge. Hence for the same CLBP patient the primary care physician may prescribe an NSAID and back stretches, the Naturopath may include a botanical such as curcumin, the interventionalist an epidural, the chiropractic manipulation. It is obvious that this is a suboptimal approach. Ideally, a generalist with a wide range of familiarity with different reductionistic and holistic modalities would first perform a careful evaluation of the patient's individual situation. They would then develop a reasonable assessment of the causes of their symptoms, including mechanical, emotional and spiritual factors. Then they would use carefully selected tests to support or refute their clinical hypothesis. They would take into account the personality and resources of the patient themselves. Then they would synthesize all these findings into a coherent therapeutic plan, making sure the patient understands and agrees with it and can reasonably carry it out. They would refer to other providers as needed, gathering a team to help the patient. Referrals could include reputable practitioners in both more reductionistic fields such as interventional pain and surgery and more holistic oriented fields such as physical therapy, psychotherapy, acupuncturists and Tai Chi teachers. Often such a team approach is key, since very few of us have mastered the wide range of skill sets that might benefit a patient.

6.4
In specialties such as primary care (e.g. family medicine, internal medicine, pediatrics) in which a wide range of skill sets is expected, residencies need to identify teachers who can teach these skill sets For example, curriculum should include at least familiarity with holistic approaches such as mind/body medicine and acupuncture in their training. Ideally, there should be training in basic holistic techniques that can be done by the primary care physician such as stress management techniques and select natural medicine that have a good evidence base of effectiveness. Learning how to properly refer to holistic oriented practitioners such as Tai Chi, Yoga teachers and acupuncturists is important (Table 1).

Primary care residencies should also teach clear indications and evidence
base for interventions and other reductionistic techniques 6.6 In more narrow focused specialties such as orthopedic surgery, residents should at least be exposed to the evidence base for holistic modalities. Teach and assess competency on choosing which patients would benefit from these modalities and how to appropriately refer Mr. Smith is a 45 y/o man with CLBP ranging in severity from 3 to 8/10 for 7 months that began after a warehouse work accident in which he herniated his right L4/5 disc with sciatic symptoms down his right leg. His symptoms are aggravated by his job where he needs to lift boxes and so he was put on temporary disability. His clinical and MRI exam correlate well. He is otherwise healthy and well adjusted with no comorbidities. Physical therapy (PT) was only modestly helpful. Therapeutic program & rationale: Mr. Jones has the common pattern of impending 'diabesity' (central obesity with metabolic syndrome spectrum of derangements), which is associated in studies with about a double risk of chronic pain. Stress likely worsens his pain. Deconditioning with core spine stabilizer muscle deficits and resultant reactive chronic para-lumbar and other related muscle tension may be a main driver of his pain. Poor correlation between spine imaging lesions and clinical symptoms makes a reductionistic 'fix it' approach to back care less likely to be successful.
A more holistic and lifestyle medicine approach with graduated exercise focusing on core strength and control and posture supported by PT, plant-based whole foods diet to reduce body inflammation, Somatics or similar modality to 'reconnect' mind/body control of paralumbar spasm to help relax these muscles and a comprehensive stress management/emotional support program are more likely to be beneficial. Natural botanicals that reduce inflammation such as Curcumin and/ or Boswellia may be useful to reduce inflammation and help prevent progression of prediabetes to DM2 and would not have clinically significant interactions with his present pharmaceutical regimen. NSAIDs would likely have an unacceptable risk/ benefit ratio by worsening GERD and HTN. Opioids generally have an unfavorable risk/benefit ratio for non-specific CLBP and should be avoided.
Competencies for learners in this case might include: 1. Understanding correlations between nutrition, obesity, DM2 and chronic pain and ability to communicate these risks and how to reverse them effectively to patients.
2. Familiarity with basic principles of both PT and mind/body modalities such as Somatics in treating CLBP and how to refer to specialists in these areas 3. Ability to guide patients on simple techniques to reduce stress, such as breathwork, progressive relaxation, meditation. Experiencing some of these techniques themselves may be a more useful learning approach than limiting to didactic knowledge. 4. Motivational interview skills to support lifestyle change 5. Basic knowledge and use of evidence-based botanical medicines for chronic pain

Example 3
Mrs. Patel is a 45 y/o second generation American with Asian Indian ancestry with CLBP ranging from 3 to 8/10 for 7 months. The back pain started after she made a left turn and an oncoming car hit her at about 20 mph. She has no sciatica or red flag symptoms or findings. An X-ray done in the ER after the accident showed mild degenerative disc disease and spondylosis. Labs done in the ER were unremarkable except for mild elevated AST and an elevated MCV on CBC. Other health issues include migraines and irritable bowel syndrome and insomnia. She denies smoking or illicit drug use and states she drinks a 'nightcap' regularly to help with her sleep and pain. She struggles with marital difficulties with her Indian husband. She is sedentary, appears deconditioned and mildly centrally obese. She prefers not to exercise or move much because she fears it will worsen her back pain. Evaluation of the LS spine shows mild ache on flexion and far extension and some para-lumbar spasm and tenderness. No red flag findings.
© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Conclusion
Chronic low back pain serves in this chapter as an example of the wide range of competencies along the reductionistic-holistic spectrum that may be needed in treating patients. Flexibility of therapeutic approach to match needs of the patient may improve outcomes. Although there is some evidence of better outcomes and value with such an integrative approach [55], more research is needed to test this hypothesis. Similarly, an integrative approach may help physicians reconnect with their reasons for going into medicine and their role as a healer. 'Walking the walk' by modeling a healthy lifestyle can restore their own health and reduce burn-out. There is little research on effective GME methods of teaching learners to balance reductionistic and holistic approaches to care, so present approaches are largely guided by experience. Given the expense and burden of suffering of chronic disease, this should be a priority area of research in GME.