Phytochemicals—God’s Endowment of Curative Power in Plants Phytochemicals—God’s Endowment of Curative Power in Plants

Phytochemicals—God’s Endowment of Curative Power in Plants tried to review the link between the knowledge of God’s pronouncement on plants as man’s source of food and drugs in the Holy Bible to the scientific proofs of the availability of phytochemicals in different species of plants. The abundance of plants in the world as vegetables, spices, fruits, etc. of which more than 80% of their chemical compositions have not been discovered empha-sizes the reasons for the search of these phytochemicals as alternative drug sources which are safer and relatively cheaper. Literature is reviewed on different phytochemicals such as alkaloids, saponins, tannins, anthraquinones, and glycosides in the form of cardiac and cyanogenetic glycosides, flavonoids, carotenoids, and phenols considering their chemical properties and their usefulness to man. This review confirmed the outburst that said “the world is too much with us; late and soon, getting and spending, we lay waste our powers: Little we see in nature that is ours.” Therefore, there is an urgent need to search for these various phytochemicals in plants so that we can utilize the potentials in these free gifts from God and not lay waste the curative power endowed on them pur- posely for man’s health benefits.


Introduction
God created plants for the use of mankind and ordered man to make use of these herbs and trees for food and for medicine as reflected in His words recorded in the Holy Bible in the books of Genesis and Revelation. The book of Genesis Chapter 1 verse 29 reported and God said "Behold, I have given you every herb bearing seed, which is upon the face of all the earth, and every tree, in which is the fruit of a tree yielding seed; to you it shall be for meat." The book of Revelation Chapter 22 verse 1 also declared "And he showed me a pure river of water of life, clear as crystal, proceeding out of the throne of God and of the Lamb." Also, in Revelation Chapter 22 verse 2, it was written "In the midst of the street of it, and on either side of the river, was there the tree of life, which bare twelve manner of fruits, and yielded her fruit every month: and the leaves of the tree were for the healing of the nation" [1].
From the work of creation, God made light on the first day followed by water on the second day and afterward created plants on the third day in the categories of grass, herb yielding seed, and tree yielding fruit, whose seed was in itself, that is, seed enclosed in fruit. This order was a divine one which no one can fathom as God is all-knowing and His understanding is unsearchable. God knew what the requirements for the growth of all these plants would be, and He ordered their creation after those requirements were met so that they could survive.
He created man lastly on the sixth day after all other things (creatures) had been made so that man could have dominion over them. He ordered man to use the herbs and tree bearing fruits for meat, that is, food, and for treating their illnesses as He understood the frailty of man. He knew all the requirements that man needed to survive and made provisions for them.
God created plants to serve man and put into these plants certain powers that are capable of healing and which in the modern times are now known as "phytochemicals." These phytochemicals are of different types according to their specificity in curing various diseases. Many individual plants were endowed with varieties of these chemical constituents, and the synergistic effects of these constituents also termed secondary metabolites endow on them their curative abilities. The healing properties of most plants are becoming more recognizable and preferable as most are associated with little or no side effect which is a common problem with the administration of most synthetic drugs (orthodox medicines) and the realization of the fact that many natural remedies carry their cures along with them [2]. Never are we reminded of Wordsworth's outburst: "The world is too much with us; late and soon, getting and spending, we lay waste our powers. Little we see in nature that is ours" [2].  [3].
The knowledge of plants especially in uses for food and medicine increased during the Neolithic Revolution. Protobotany which was the first prescientific written record of plants did not begin with food but was born out of the medicinal literature of China, Egypt, India, and Mesopotamia [4]. It was observed by botanical historian, Alan Morton, that agriculture was the occupation of the poor and uneducated, while medicine was the profession of the socially influential shamans, priests, magicians, physicians, and apothecians who were more likely to put their knowledge in record for posterity [3].

The relevance of botany in medicine
Lists of different plants and herb concoctions for pharmaceutical purposes were dated back to 481 BC-221 BC in ancient China. Over the centuries, the written knowledge of herbal pharmaceuticals was contributed to by many Chinese writers [5]. The study of medicinal plants was not being neglected, and a full synthesis of ancient Greek pharmacology was compiled in De Materia Medica c. 60 AD by Pedanius Dioscorides (c. 40-90 AD) who was a Greek physician with the Roman army [6]. The lives of the European middle ages were based on agriculture in the fifteenth and sixteenth centuries until when printing came into limelight which did not publish dissertations on agriculture but rather preferred the lists of medicinal plants with descriptions of their attributes and inherent power (efficacy). Records had it in most ancient history that Herbal which was the first series of books written on plants indicated botany to form a part of medicine [3]. People who contributed to Herbal were mostly university gardens' curators [7], and compilations of classic texts in Herbal were mostly derived from De Materia Medica.

Separation of botany from medicine
The need for accurate and detailed plant descriptions meant that some herbals were more botanical than medicinal. Herbals made contributions to botany by initiating the science of plant description, classification, and botanical illustrations. Botany and medicine were the same up to the seventeenth century, but those books that emphasized medicinal aspects omitted the plant lore and eventually became the modern pharmacopeias; those that omitted medicine became more botanical which evolved into the modern plant description compilations called Floras and are often backed by specimens deposited in a herbarium (a collection of dried plants that verified the plant descriptions given in the Floras). The transition from Herbal to Floras marked the final separation of botany from medicine [8].

Relevance of medicinal plants
Medicinal plants are gaining popularity in usage due to a large number of people in search of health remedies with little or no side effect which is the problem of most chemically synthesized drugs. Considerable attention is presently given to the use of eco-friendly and biofriendly products from plant origin for the prevention and cure of human and animal health challenges (diseases) [9,10]. This problem of side effects of most chemically based drugs has spurred the Western world to looking into natural products that are safe, effective, and affordable. It has been documented that 80% of the world's population has a strong belief in traditional medicine, especially drugs from plant origin for their primary health care [9,10]. Medicinal plants, for example, neem leaves and stem bark (Azadirachta indica), pawpaw leaves (Carica papaya), mango leaves and stem bark (Mangifera indica), and Cinchona bark have been in use in one form or the other traditionally. No doubt, the plant kingdom is rich in diverse array of plants whose medicinal attributes (potencies) are yet to be unraveled [9,10]. The various uses of some common medicinal plants from Nigeria used for treating various diseases highlighting the parts of the plants used are represented in Table 1.

Harvest of medicinal plants
Medicinal plants should be harvested at the appropriate seasons as their medicinal properties vary with respect to different seasons. The medicinal properties may be located and restricted to a particular part of the plant, and the medicinal attributes is also affected by the age of the plant. A medicinal plant of a particular age for drug processing should therefore be harvested at the correct season of the year to prevent loss or changes in its phytochemical constituents. The period of storage in shade or sun and the geographical locations of the medicinal plants also play important roles in the medicinal properties of the plant [11].

Identification and standardization of active principles in medicinal plants
Medicinal plants are very rich in chemical compounds which they produce for their own defense and are known as secondary metabolites (phytochemicals) and their medicinal potencies are attributed to these chemical compounds [11]. A medicinal plant may contain a mixture of different phytochemicals, for example, saponins, which have ability to lower cholesterol; alkaloids which are rich in nitrogenous compounds and are stimulants; tannins which are natural antibiotics; anthraquinones used as laxative and dye; cardiac glycosides which are good cardiovascular drugs; and phenols and flavonoids which are rich in antioxidants. The ability to identify these biologically active compounds in a medicinal plant serves as a guide in its quality control and dose determination. Most medicinal plants in Nigeria have not been screened for their complete phytochemical compositions, and this would help in their dose determination and standardization. The entire world has more than 250,000 species of higher plants gathered from conservative studies, and only an insignificant percentage has been exhaustively studied for their potentials as drug sources [11].

Plant-based drugs
In the ancient times, plants served humankind as the source of all drugs with most therapeutic agents provided by the higher plants. The World Health Organization estimated that about 3.5-4 billion people in the world depend on traditional medicine as sources of drugs for their primary health care (80% of people in the developing countries and 85% of traditional medicine rely on plant extracts) [12]. Plant-derived drugs represent 25% of the prescription of drugs in the market in the United States of America [13], and from 1983 to 1994, 39% of the new approved drugs were of natural origin; this included original natural products, semisynthetically derived products from natural origin and synthetic products based on models from natural products [14]. From 87 approved anticancer drugs, a survey revealed that 62% were of natural origin or is derived from modeling of the natural product parents [14]. Paclitaxel, vincristine, podophyllotoxin (a natural product precursor), and camptothecin (a natural precursor for water-soluble derivatives) are among those clinically useful drugs.

Phytochemicals -Source of Antioxidants and Role in Disease Prevention
These substances contain properties which are essential as new chemotherapeutic agents useful for treatment in the hospitals. There are some new approaches to drug discovery, such as combinatorial chemistry and computer-based molecular modeling design, and none of them can replace the role of natural products in drug discovery and development. Examples of plant-based drugs are artemisinin, gingerosome, and quinine.

Synergy in relation to pharmacological action of phytomedicine
Most herbs exhibit their effects on a variety of constituents, and the idea of synergy within and between them is gaining acceptance [15]. Most herbal medicines are not well documented to prove whether they are acting truly in a synergistic way or by additive effects. It is usually difficult to clinically evaluate herbal preparations without the knowledge of their synergistic effects. Biological activity may be absent in the crude drugs but may contain some components that can enhance their active components' potency. One of such examples is St. John's wort (Hypericum perforatum, family Hypericaceae), a clinically proven herb which has efficacy as an antidepressant. Hypericins responsible for its activity was found to be very weak, and impurities in the fraction used gave the additional results which suggest multiple (polyvalent) and synergistic effects. St. John's wort thus represents a good example of an herb which may exhibit synergism and polyvalent action [16]. The use of combinations of herbs can also result in synergism or enhancement of activity of herbal drugs. In case of multiple herb extracts, some of the herbs enhance the potency of the real effective herb, and in some cases, their constituents could reduce the toxic effects of the main herb, resulting in a safe herbal combination tolerable for consumption by the human system [17].

Phytoconstituents in medicinal plants
Phytochemicals are chemicals found in plants that protect plants against bacteria, viruses, and fungi. Eating large amount of brightly colored fruits and vegetables, whole grains/cereals, and beans containing phytochemicals may decrease the risk of developing certain cancers as well as diabetes, hypertension, and heart disease. The actions of phytochemicals vary by the type of the food and the color. They may act as antioxidants or nutrient protectors or prevent carcinogens from forming. The term phytochemical refers to a wide variety of compounds made by plants but is mainly used to describe those compounds that may affect human health. Scientists have identified thousands of phytochemicals, although only a small fraction has been studied closely. Some common examples of phytochemicals include betacarotene (with other carotenoids), vitamin C, vitamin E, and folic acid [18]. Phytochemicals have shown various physiological actions [19,20]. Among the numerous phytochemicals in existence are the following with their usefulness:

Alkaloids
These are the largest group of secondary metabolites made of ammonia compounds comprising basically nitrogen bases synthesized from amino acid building blocks having various radicals substituting one or more of the hydrogen atoms in the peptide ring, containing mostly oxygen [21]. The compounds have basic properties and are alkaline in reaction, turning red litmus paper blue. In fact, one or more nitrogen atoms that are present in an alkaloid, typically as 1°, 2°, or 3° amines, contribute to the basicity of the alkaloid. The degree of basicity varies considerably, depending on the structure of the molecule, presence, and location of the functional groups [22]. They react with acids to form crystalline salts without the production of water [21]. Alkaloids exist majorly in solid states as atropine, liquids containing carbon, hydrogen, and nitrogen.
Alkaloids are mostly readily soluble in alcohol but are sparingly soluble in water though their salts are usually soluble in water. Their solutions are usually very bitter; alkaloids defend plants against herbivores and pathogens and are used widely as stimulants, narcotics, pharmaceuticals, and poisons because of their biological potencies [23]. Alkaloids, in nature, are found in large quantities in the seeds and roots of plants and mostly in combination with vegetable acids. Alkaloids are useful as central nervous system (CNS) stimulants and anesthetics in pharmacological applications [23].
Alkaloids also find its usefulness as pain relievers [24]. Atropine is an alkaloid used widely in medicine as an antidote to organophosphate poisoning, while caffeine stimulates CNS and respiratory systems. Caffeine also serves as an antidote to barbiturate and morphine poisoning, while emetine (from Cephaelis ipecacuanha) root is useful in the treatment of protozoal infections, for example, amoebic dysentery.

Tannins
The tannin compounds are found mainly in many plant species which help to confer on them protection from predators and probably pesticides; they also help in regulating plant growth [25]. The dry and puckery feeling in the mouth after eating unripe fruits or red wine is attributed to the astringency from the tannins [26]. The destruction or modification of tannins with time in like manner plays an important role in the ripening of fruit and the aging of wine. They are acidic in reaction, and this is attributed to the presence of phenolics or carboxylic group [27]. They form complexes with proteins, carbohydrates, gelatin, and alkaloids.
Tannins are divided into hydrolysable tannins and condensed tannins. Hydrolysable tannins, when hydrolyzed, produce gallic acid and ellagic acid, and depending on the type of acid produced, the hydrolysable tannins are called gallotannins or ellagitannins; when tannins are heated, they form pyrogallic acid [25]. The presence of phenolic group in tannins confers on them their usefulness as an antiseptic [27]. Common examples of hydrolysable tannins include the aflavins (from tea), daidzein, genistein, and glycitein.
Plants that contain tannins have been reported to be astringent in nature and are useful in treating intestinal disorders like diarrhea and dysentery. This means that tannins possess antimicrobial activity [28,29]. The antimicrobial activities possessed by these plants could support their use in West Africa for treating gastrointestinal disorders [30]. Tannins are also potent antioxidants [31,32].

Saponins
Saponins are a class of phytochemicals present in abundance in numerous species of plants.
They are specifically amphipathic glycosides and are grouped phenomenologically by their production of soap-like foaming when shaken in aqueous solutions (phenomenology-study of structures of consciousness as experienced from the first-person point of view). They are grouped structurally by possession of one or more hydrophilic glycoside moieties combined with a lipophilic triterpene derivative [33].
Two major groups of saponins exist which are steroid and triterpene saponins. Saponins are insoluble in ether but soluble in water, and on hydrolysis, they give aglycones like glycosides. They cause hemolysis of blood and cattle poisoning as they are known to be extremely poisonous (27). Apart from causing irritation to mucous membranes, they have a bitter and acrid taste. They are soluble in alcohol and water but insoluble in solvents like benzene and n-hexane that are organic and nonpolar; therefore, they are mostly amorphous in nature. Saponins are therapeutically important because they lower bad fats in the body (hypolipidemic) and have anticancer potentials. Saponins work in synergy with the cardiac glycosides [22].
Saponins are known to produce inhibitory effect on inflammation [34]. Saponins help in lowering cholesterol which will subsequently reduce the risk of cardiovascular diseases such as hypertension which usually leads to stroke [35].

Anthraquinones
Anthraquinones are phenolic and glycosidic compound derivatives and are solely derived from anthracene leading to the production of variable oxidized derivatives like anthrones and anthranols [36,21]. Industrially, anthraquinones are used for washing of bowels (laxatives) and in dye production [37].

Glycosides
Glycosides are the condensation products of sugars (polysaccharides inclusive) with different varieties of organic hydroxyl (occasionally thiol) compounds. Glycosides are colorless, crystalline water-soluble plant constituents found in the cell sap. Glycosides chemically contain a carbohydrate (glucose) and a noncarbohydrate part (aglycones or genin) [27,21]. Glycosides can be readily hydrolyzed into its components with mineral acids as they are neutral in reaction and are purely bitter principles commonly found in plants of the family Genitiaceae.
The action of the bitters on the gustatory nerves results in increased flow of saliva and gastric juices [27,21]. Some of the bitter principles due to the presence of tannic acid are either used in restricting flow of blood (as astringents), function in the reduction of thyroxin, and thereby regulate cell metabolism and growth or as antiprotozoal. Examples of glycosides include cardiac glycosides which act on the heart and anthracene glycosides act as purgative and for treatment of skin diseases, while chalcone glycosides are used as anticancer agents [22]. The extracts of plants containing cyanogenetic glycosides have been reported to be useful as flavoring agents in many pharmaceutical formulations. Amygdalin has been used in the treatment of cancer [hydrogen cyanide (HCN) liberated in stomach kills malignant cells] and also as a cough suppressant in various preparations. Intake of cyanogenetic glycosides in excess quantities can be dangerous [22].

Cardiac glycosides
Plants long used as arrow poisons (e.g., Strophanthus) or as heart drugs, for example, digitalis, contain cardiac cardiotonic glycosides [38]. Cardiac glycosides help in the treatment of congestive heart (cardiac) failure; that is, they help a weakened heart to be strengthened and function more efficiently [39].

Cyanogenetic glycosides
Cyanogenetic glycosides are a group of materials derived majorly from plants which on hydrolysis liberate hydrocyanic acid (HCN). They therefore call for attention and an object of concern because of their ability in causing damage by poisoning that are natural toxicants. Cassava, an example of a food plant (Manihot esculenta), produces cyanogenetic glycosides which require prolonged hydrolysis and boiling in preparation of the starchy tuberous roots to release and evaporate off the HCN before consumption [40].

Flavonoids
Flavonoids belong to a group of important polyphenols which are widely distributed among plants. They have more than one benzene ring in its structure and are used as antioxidants or free radical scavengers [27]. Flavans are parent compounds from which they are derived.
Out of over 4,000 flavonoids that exist, some are found as pigments in higher plants. About 70% of plants contain common flavonoids such as quercetin, kaempferol, and quercitrin. Among other groups of flavonoids in existence are flavones, flavans, anthocyanidins, dihydroflavons, flavonols, chalcones, and catechin [27]. Flavonoids function to reduce the risk of coronary heart diseases [41] and possess anticoagulant, anti-inflammatory, and aphrodisiac properties [42].

Phenols
Phenols contribute to the prevention of various degenerative diseases that act as an antioxidant [41]. Phenols, phenolics, or polyphenolics are chemical constituents that are commonly present as natural color pigments giving fruits of plants their colors. The action of phenylalanine ammonia lyses (PAL) on phenylalanine leads to the synthesis of phenolics in plants.
Among the various functions of phenols is in plant defense against pathogens and predators of herbivores and therefore used in the control of human infections caused by pathogens [43]. The most common of phenolic compounds widespread in plants is caffeic acid which is followed by chlorogenic acid, the causal agent of excessively sensitive inflammation of the skin (dermatitis) among humans [27]. Phenolics are natural antioxidants functioning as nutraceuticals and available in red wine, apples, and green tea. They serve as anticancer and anti-inflammatory agents as well as prevent heart diseases.

Steroids
Plant steroids also known as cardiac or steroid glycosides are one of the most naturally occurring plant phytoconstituents that are applied therapeutically as cardiac drugs or arrow poisons [21]. The cardiac glycosides are majorly steroids having a natural ability to exert specific and powerful action on the cardiac muscle mainly when injected into animal or man. Steroids (anabolic steroids) have the ability to promote nitrogen retention in osteoporosis (a disease following menopause in women causing bones to be porous and subjected to fracture) and in animals with wasting illness [36,23]. Steroids have the ability to exhibit activities such as antifungal, antiviral, antileukemic, hypnotic, antipyretic, and muscle-relaxant activities and are found in large quantities in many plants [44].

Carotenoids
Carotenoids are coloring pigments in plants especially fruits and vegetables; these act as antioxidants to protect the body against the activities of free radicals [45].

Mechanism of action of phytochemicals
Phytochemicals may inhibit microorganisms, may interfere with some metabolic processes, or may modulate gene expression and signal transduction pathways [46][47][48]. Among the many uses, phytochemicals may either be used as chemotherapeutic or chemopreventive agents. Chemoprevention refers to the use of agents to inhibit, reverse, or retard tumorigenesis. In this sense chemopreventive phytochemicals are applicable to cancer therapy, and molecular mechanisms may be common to both chemoprevention and cancer therapy [49,50].
The mechanism of action of phytochemicals in general is attributed to proton-motive force disruption, active transport, cytoplasmic membrane disturbance, electron flow, and cell contents' coagulation [51]. There are different modes of action of phytoconstituents which could be anticancer, anti-inflammatory, antioxidant, anti-ulcer, antidiabetic and may be a multifunctional target.

Conclusion
God is the creator of all things that are in existence of which plants which are in abundance and of various diversities are among. He put plants in place to serve man especially for food and medicine to heal their diseases. It is therefore imperative to search more into medicinal plants for phytochemicals which can provide a clue in terms of lead (active) compound discovery for the cure of many so-called incurable diseases like cancer, diabetes, hypertension, ulcer, and other degenerative diseases that are just being managed by medical practitioners till the patient passes on. It is realized that many natural remedies carry their cures along with them; therefore, it could be concluded that botanists (plant scientists), pharmacists, pharmacognosists, pharmacologists, chemists, biochemists, and all other fields related to the science of drug discovery should rise up to these challenges of sourcing from plant alternative medicines which God had placed into our hands only left to be discovered.