The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer

the chapter in “ MR Imaging, ” we want to present the role of MRI in the accurate manage- mentoffocaltherapywith HIFUforthelocalizedprostatecancer.


Introduction
High-intensity focused ultrasound (HIFU) produces ultrasound waves generated by a spherical transducer, delivering ultrasonic energy to pinpoint foci millimeters in diameter [1]. The thermal and mechanical effects of HIFU cause destruction within prostate tissue [2,3]. Specifically, coagulative degeneration quickly develops and is a primary mechanism for decreasing blood flow [3,4]. Cavitation, a mechanical effect of HIFU, occurs because of the rapid cycling from compression to refraction by the ultrasound waves and results in the formation of microbubbles in tissue. When these bubbles reach the size of resonance, they collapse and produce highpressure shock waves, destroying adjacent tissue [5]. Clinically, HIFU energy is delivered in a pulsed mode, and pulses are defined by treatment cycles and energy intensity in watts. Pulse characteristics define the size of the ablation area, including necessary margins to ensure full tumor coverage. The resulting tissue effects are a function of the frequency (wavelength) and intensity (I, in W/cm 2 ) of the applied energy. Intensity is a function of the excitation (voltage) and duration of the energy pulse. The exact size of the ablated area depends on the type of device used, shape of the piezoceramic working element of the transducer, ultrasound frequency and duration of pulsed energy applied, degree of sonication absorption by the tumor tissue, and focal intensity achieved.
Because the area involved in a single treatment using HIFU is extremely small, only minor temperature changes are observed outside of the focal zone [3], making it an attractive therapeutic modality for focal treatment of the prostate, with the aim of curing the cancer while preserving continence and erectile function. Clinical trials of focal ablation of prostate cancers with HIFU have been reported [6][7][8][9][10][11]. In the management of the focal therapy, MRI has the role in the localization of the targeted lesion, the evaluation of the treatment effectiveness, and the local recurrence after the treatment.

The technology of the HIFU in the treatment of the prostate cancer
After the early studies for the treatment of organ-confined prostate cancer, the Sonablate ® device and Ablatherm ® device have been further enhanced to include treatment planning capabilities and improved therapeutic technologies.
In the treatment planning, the Sonablate ® transrectal HIFU probes use proprietary transducer technology with low-energy ultrasound (4 MHz) for imaging of the prostate and high-energy ablative pulses (site intensity: 1300-2200 W/cm 2 ) for treatment delivery. For the Ablatherm ® device, the transrectal HIFU probes use 7.5 MHz pulses for imaging of the prostate and 3 MHz for the delivery of high-energy ablative pulses (site intensity, 1300-2200 W/cm 2 ). In recent applications of HIFU, the treatment range was planned using a MRI-TRUS fusion image. Additionally, reconstructed three-dimensional (3D) planning modes have been integrated into the SB 500 V4 and AB integrated devices, facilitating accurate planning of treatment range. Because of the inherent technology of HIFU treatments, there is no need to puncture the prostate during treatment; however, this makes accurate treatment planning essential for successful focal HIFU therapy.
In the treatment, intraoperative images are available during the procedure. The "popcorn" phenomena formed by the cavitations of tissue may act as an indicator of treatment efficacy. The SB500 tissue change monitoring system (TCM) predicts treatment efficacy by calculation of radio frequency signal from an area of interest and classifies it based on a 3-color system; green: insufficient change to cure, yellow: moderate change, and orange: large change. Based on the color indicated on the treated area, intraoperative retreatment for an insufficiently treated zone (green area) would then be performed. A recent development in the field of adaptive treatment planning is the Focal One ® . This device has a dynamic focusing transducer made of 16 isocentric rings and allows the user to electronically steer the ultrasound beam and move the focal point of the transducer to a maximum of eight different points (32-67 mm from the transducer).
3. The role of MRI in the management of focal therapy 3.1. The localization of the clinically significant cancer in the prostate with MRI-TRUS fusion image-guided prostate biopsy Multiparametric MRI (mpMRI) improves the imaging of the clinically significant prostate cancer in the prostate [12,13], and the information of mpMRI has been used for the precise diagnosis and localization of the clinically significant prostate cancer. MRI-TRUS fusion image-guided biopsy achieved accurate prostate biopsy based on MRI, combining the superior sensitivity of MRI for targeting cancer-suspicious lesions with the practicality and familiarity of TRUS. With the MRI-TRUS fusion devices, the stored MRI and real-time TRUS are superimposed using computer software to enable targeted biopsy of cancer-suspicious lesions [14]. MRI-TRUS fusion biopsy device "BioJet ® " was approved by FDA after the evaluation of the accuracy with phantoms. We reported the BioJet ® experience of the usefulness of the precise diagnosis of the clinically significant cancer [15]. In the 30 patients from whom whole-mount specimens were taken, we found 43 clinically significant cancers, of which 41 (95%) had been detected by both the targeted and systematic biopsies. The median major diameter of significant cancers in the wholegland specimens was 12 (range: 5-28) mm; lesions ≤10 mm represented 59% of the significant cancers (n = 24). Of the significant cancers ≤10 mm (n = 24) in whole-mount specimens, 96% (n = 23) were correctly diagnosed by biopsy. Gleason scores and locations of biopsy-proven significant cancers corresponded to histopathological findings for the whole-mount specimens, since the localization of the clinically significant cancer in the prostate is important for the precise focal therapy. Since February 2016, the biopsy with BioJet was approved as the advance medical technique by Japanese Ministry of Health, Labor, and Welfare.

The evaluation of the effectiveness and the local recurrence of the prostate cancer after the focal therapy with HIFU
The treated areas with HIFU in the prostate appear as nonenhanced areas on contrastenhanced T1-weighted MRI, and subsequent transrectal biopsies have been able to remove homogenous necrotic tissue sections from the nonenhanced area [16]. Therefore, contrastenhanced MRI has been considered to be the evaluation method of choice to demonstrate the effectiveness of HIFU for localized prostate cancer. We reported the time-dependent changes in blood flow within the prostate treated with HIFU on contrast-enhanced MRI between postoperative days 1 and 14 [16]. In addition, pathological analysis showed vessel damage with coagulative degeneration and detachment of vascular endothelial cells in HIFU-treated prostate tissue [16]. Previous studies [5] have shown that these time-dependent changes in blood flow within the prostate are likely due to the primary thermal effects induced on the tissue and vessel damage by coagulative degeneration in the prostate and that cavitation rapidly induces the detachment of vascular endothelial cells, gradually decreasing blood flow secondary to vessel obstruction. Future large-scale studies should investigate the most appropriate timing of contrast-enhanced MRI for precise feedback regarding the effectiveness of HIFU. Using the contrast-enhanced MRI, the evaluation of the effectiveness and the local recurrence of the prostate cancer needs to be evaluated after the focal therapy with HIFU.
4. The original protocol and the early experience of the focal therapy for the prostate cancer in our institution  CTCAE Grade 2 was found in one patient (6.7%). In conclusion, the anatomical region selected focal therapy with HIFU would have potential to provide promising results with accurate treatment for the significant cancer and low morbidity.

Conclusion
MRI has the role of the management of the focal therapy with HIFU. Clinical trials have shown potential for effective focal treatment with HIFU-localized prostate cancer. Further oncological and functional outcomes in the patients treated with focal therapy with HIFU would be expected.