Patients Suffering from Intractable Diseases Treated Effectively with Medicines of Kampo and TCM

There are diseases that cannot be cured by conventional therapies. In Japan, more than 90% of medical practitioners treat patients with alternative medicines such as Kampo medicine (herbal medicine based on Japanese Kampo theory) or traditional Chinese medicine (TCM) that do not respond to conventional treatments. The author also treated these patients suffering from cardiovascular diseases, vasculitis diseases, nephrosis, hyperlipidemia, and female disorders including menstruation disorders, incurable pain diseases such as glossodynia and herpes zoster or herpes virus infectious diseases, and other diseases such as female-related ones and diseases that need five-face theory to cure and the administration of gui-zhi-fu-ling-wan ( 桂枝茯苓 丸 ) before aspiration biopsy, in breast cancer patient, to raise the detection rate of cancer cells. Interestingly, diseases specified as “intractable diseases” by the Japanese Ministry of Health, Labor, and Welfare sometimes respond to TCM treatment quite successfully, probably because TCM and Kampo medicine systems have their own theories and their own medicines quite different from that of conventional therapies. Finally, I often experienced plural number of prescriptions for the problematic organs (based on five element theory) administered simultaneously often lead to dramatical improvement. This will mean problematic organs treated simultaneously will lead to quick recovery through synergistic actions among organs. The successfully treated clinical courses after the administration of TCM or Kampo medicines are described here. vasculitis involves small-and medium-sized arteries, capillaries, veins, and venules. The histopathological features of CSS are granuloma‐ tous reactions in the various tissues of any organ in the body, but lung involvement is predominant, with manifestations in the skin, cardiovascular system, kidney and peripheral nervous system, and also occasionally the gastro- intestinal tract. Although its pathogenesis is uncertain, it has a strong association with asthma, eosinophilia, granuloma and vasculitis. (one case refractory to steroids and therefore without steroid treatment, one case with steroid dependency and six cases with nephrotic syndrome). This combination was effective in five of six patients with proteinuria. In one recurrent case, the combination of Ba-wei-di-huang-wan and Bu-in-tang ( 補陰湯 ) led to recovery. These results show that these formulas may exert a synergistic effect responsible for improvement in urinary protein excretion. Abstract A 41-year-old female was diagnosed with acute lymphocytic leukemia (ALL) at a university hospital. She could not tolerate chemotherapy and started alternative Chinese herbal medicine including zi-xue-tan ( 紫雪丹 ) (Table 6) at the time of her fourth recurrence. This provided transient improvement followed by aggravation after her intake was decreased. A blood test suggested complete recovery. Although cyclophosphamide had previously been ineffective, this time together with Chinese medicine, it led to a dramatic improvement. rheumatism and brain embolism. After thorough examination, diagnosed L2 (by the French–American–British, FAB, classification) acute lymphocytic lymphoma. Chemotherapy with vincristine, prednisolone, daunorubicin, mercaptopurine, methotrexate, L-asparaginase, vindesine, and adriamycin was instituted. Abstract The intake of hot water extracts including Ganoderma lucidum or WTMCGEPP (Wisteria decreased the pain of acute shingles in five Japanese patients, two with herpes zoster with trigeminal ophthalmia (74 years), one with lower body zoster (70 years), one with herpes zoster oticus (17 years), and one with leg herpes (28 years) without conventional therapies including antiviral drugs. In all patients, pain began to decrease within a few days of the initiation of intake and completely


Introduction
There exist diseases that cannot be cured by conventional therapies.
In Japan, more than 90% of medical practitioners treat patients with Kampo medicine (herbal medicine based on Japanese Kampo theory) or traditional Chinese medicine (TCM) that do not respond to conventional treatments.
Furthermore, about 80% of universities with medical departments have sections that deal specifically with Kampo medicine.
Many Japanese doctors use Kampo medicines, because of the existence of patients who are not successfully cured after trying all possible conventional therapies I have been engaged in TCM treatment for more than 35 years, and I have used Kampo medicines or herbs selected based on TCM principles in patients who do not respond to conventional therapies including those who suffer terrible side effects with conventional medicines or cannot take them, for other reasons.
Interestingly, diseases specified as "incurable" by the Japanese Ministry of Health, Labor and Welfare, often respond to TCM treatment quite successfully.
TCM and Kampo medicine are treatment systems that have their own theories and their own medicines which consist of natural remedies.
These systems can be used as complementary or alternative therapy for conventional therapies.
In this chapter, I will introduce clinical courses after the administration of TCM or Kampo medicines, in cases of cardiovascular diseases, vasculitis diseases, nephrosis, hyperlipidemia and female disorders including menstruation disorders, incurable pain diseases such as glossodynia (burning mouth syndrome) and herpes zoster or herpes virus infectious diseases and other female-related diseases, and diseases that need five-face theory to cure.
Finally, by the administration of gui-zhi-fu-ling-wan (桂枝茯苓丸) before aspiration biopsy, in breast cancer patient, the detection rate of cancer cells was found to increase. Hereafter, the name of organ starting with capital letter means organ in TCM. The terminology of TCM is mainly based on WHO International Standard Terminologies on Traditional Medicine in the western Pacific region. er-hao-fang is composed of chi-shao-yao (赤芍薬)5, chuan-xion (川芎)5, hong-hua (紅花)4, danshen (丹参)5, and Jiang-xian (降香) 4g/day. This formula was first reported at zhon-guo-yi-xueke-xue-yuan.

Introduction
Kampo medicines improved blood test results and the quality of life (QOL) in two cases of vasculitis cases. One with Churg-Strauss-syndrome (CSS) and with Henoch-Shönleinpurpura (HSP), after inadequate treatment with conventional therapies

Summary
Objective: Two vasculitis syndrome patients, one with CSS (Case 1) and one with HSP (Case 2) exhibited persistent symptoms and abnormal blood tests after treatment with conventional therapies.
To improve their situation, based on the tenets of traditional Chinese medicine (TCM) theory, herbal medicines were applied.

Results:
In Case 1, the patient presented with hypereosinophilia, venous thrombosis, pulmonary infarction, a decreased platelet count, ulnar nerve palsy and Raynaud's phenomenon, which led to a diminished QOL. After starting the Kampo medicines, the patient improved quickly and recovered within 11 months. In Case 2, persistent purpura, abdominal pain, and bloody feces quickly improved and disappeared after Kampo medicine treatment. Prednisolone was stopped at 21 days after starting the Kampo medicines and there has been no sign of relapse to date.

Conclusion:
Kampo medicines helped clear the persistent abnormal symptoms and improve laboratory findings of two vasculitis syndromes, Churg-Strauss syndrome (CSS) and Henoch-Shonlein purpura (HSP), which had responded inadequately to the conventional therapies administered.

Introduction
Churg-Strauss Syndrome (CSS) and Henoch-Sholein purpura (HSP) are classified as vasculitis syndromes, in which inflammation and blood vessel damage are common and may lead to various pathologies. CSS is rare, and necrotizing vasculitis involves small-and medium-sized arteries, capillaries, veins, and venules. The histopathological features of CSS are granulomatous reactions in the various tissues of any organ in the body, but lung involvement is predominant, with manifestations in the skin, cardiovascular system, kidney and peripheral nervous system, and also occasionally the gastro-intestinal tract. Although its pathogenesis is uncertain, it has a strong association with asthma, eosinophilia, granuloma and vasculitis.
HSP is usually seen in children, and is characterized by palpable purpura, arthralgia, gastrointestinal signs and glomerulonephritis. It is a small-vessel vasculitis. The pathogenic mechanism is presumed to be immune-complex deposition. A skin biopsy specimen is useful to confirm leuko-cytoclastic vasculitis with IgA and C3 deposition by immune-fluorescence.
These diseases usually exhibit a good response to corticosteroid hormones. However, some patients do not completely recover and suffer from an incomplete remission state with degraded QOL.
The present CSS case improved to some degree with conventional therapies in a university hospital at the acute stage, but at the chronic stage he continued to exhibit hypereosinophilia, venous thrombosis, pulmonary infarction, decreased platelet count and Raynaud's phenomenon. The patient with HSP showed improvement primarily with steroidal hormones. However, his condition worsened soon after a tapering down of the prednisolone.
From the standpoint of TCM theory, we diagnosed the pathogenesis of these diseases as being related to "static blood" [1] and in vasculitis, as related to "dampness-heat" [2,5,6], primarily in the morbid vessels, and also, in Case 1, a yang deficiency (coldness of the fingers and limbs and/or sensitive to coldness) [3].

Case 1: A 13-year-old-boy with CSS
Main Complaints: Hypereosinophilia, left femoral venous thrombosis, pulmonary infarction, decreased platelet count, Raynaud's phenomenon, ulnar nerve palsy Past History: For three years prior to his admission to the university hospital, the patient suffered from malaise, petechiae, purpura and allergic rhinitis. Hay fever also began from last year.
Present Illness: For 3 years prior to admission, main complaint started and also experienced pain with edema of the legs after extended walking, despite conventional therapies. He was diagnosed with CSS with hypereosinophilia, vasculitis with extravascular eosinophil accumulation, diffuse pulmonary infiltrate, and ulnar nerve palsy.
He also had left femoral deep venous thrombosis and pulmonary infarction. On the 5th day after hospitalization for suspected pneumonia with septic shock, he received pulse doses of methyl-prednisolone and gabexate mesilate. Following this treatment, his fever, chest pain, and diffuse pulmonary infiltrate disappeared and his eosinophile count normalized (Fig-ure1). For the persistent left femoral deep venous thrombosis and pulmonary infarction, he was given heparin and warfarin with prednisolone which are continued to be administered even after his discharge from the hospital (Figure 2). The pulmonary segmental shadow caused by the pulmonary infarction disappeared after 6 months. The left femoral deep venous thrombosis and ulnar nerve palsy disappeared after 9 months (Figures1, 2, 3).
At 81 days after the patient's discharge from the hospital, the Kampo medicine "Chi-ling-tang (柴苓湯)" (TJ 114) [4] was started (2packs/day: for adult 3 packs is required; 3 pack includes 9 g of herbal mixtures consisting of 3g of excipient and 6g of dried herbal extracts. Dried herbal extracts/day is derived from chai-fu (.柴胡)7 g, zhu-ling (猪苓)3g, ze-xie (沢瀉)5 g, ren-shen (人   The doctor in chief decided to apply Kampo medicine, because even at 7 months after discharge there were no signs of improvement and the patient's QOL was suffering. The patient visited the author's clinic on the 224 th day after discharge from the hospital.

Present States:
The patient's height was 166cm and weight was 65kg. He had a floating, fine, and weak chi mai (尺脈) (indicating Kidney yang deficiency). His tongue body was pale red and showed thin tongue fur. Sublingual collateral dark vessels were swollen.
Identification: Following TCM theory, the patient was diagnosed as having "static blood" [1] based on thrombosis and infarction of the blood vessels and dark vena sublingualis, as well as "dampness-heat" [2,5] in the affected vessels, based on vasculitis, and as having "yang deficiency" [3] based on his cold limbs, sensitivity to coldness, and Raynaud's phenomenon.
Treatment: Activate blood to remove stasis. Add and promote yang circulation.

Discussion:
The Kampo medicines selected in this case were chosen for the particular activities of the herbs. They work synergistically to produce improvement.

Case 2 A 2-year-old boy
Main Complaint: Purpura, abdominal pain, bloody feces Past History: In the middle of April 2000, the patient caught a common cold. On April 25, petechiae appeared on his right leg and then spread to his left leg and both forearms. Abdominal pain with watery diarrhea, bloody stool, and knee joint pain were also noted, with the latter appearing and recovering spontaneously.
As shown in Figure 4, in spite of the tapering down of the prednisolone, soon after the administration of the Kampo medicines, the purpura and abdominal pain drastically decreased and the bloody stool subsided. Despite the fact that the patient stopped the prednisolone 3 weeks after starting the Kampo medicines, his improved condition continued, leading to his discharge from the hospital [19].

Discussion:
In Case 1, the platelet decrease might have been the result of a pulmonary infarction. The prednisolone pulse therapy may have aggravated the infarction despite the patient's good QOL. In CSS with eosinophilia and systemic vasculitis, "blood stagnation" is present due to the pulmonary infiltrate of eosinophils caused by the vasculitis. As mentioned earlier, mu-tan-pi (牡丹皮) [8], tau-ren (桃仁) [9], zhe-chong ( 虫) [10], and sui-zhi (水蛭) [11] resolved the blood stagnation and accelerated blood flow.
Inflammation implies "dampness-heat" in TCM, Huan-ren-jie-du-teng (黄連解毒湯) which traditionally relieves heat and dampness was applied. These formulas and remedies are considered to work synergistically to prompt recovery.  In Case 2, as in Case 1, vasculitis has the characteristic of "heat and dampness", for which Huan-lien-jie-du-tang was applied. Deposits of immune complex in the blood vessels or purpura mean blood stagnation in TCM, for which Gui-zi-fu-ling-wang (桂枝茯苓丸) was applied. The fact that the patient preferred cold drink, and was feverish with a rapid pulse rate suggested Yin deficiency with internal heat [15], for which San-wu-huang-qin-tang was prescribed (TJ-121). These prescriptions are also believed to work synergistically to effect a quick recovery.
These cases of systemic vasculitis had "blood stagnation" and "dampness-heat" in TCM terminology. Properly selected remedies for "blood stagnation" and "heat and dampness" seemed to help to achieve patient improvement.

Abstract
The dose of steroid hormone was decreased or eliminated by the addition of Kampo medicines to cure patients suffering from nephrotic syndrome.
Based on these formulations, the new combination of Ba-wei-di-huang-wan (八味地黄丸), Xiaochai-hu-tang (小柴胡湯), Si-wu-tang (四物湯), and huang-lian-jie-du-tang (黄連解毒湯) (hereafter this combination of four prescriptions shortened to BXSH) proved to be effective in eight cases (one case refractory to steroids and therefore without steroid treatment, one case with steroid dependency and six cases with nephrotic syndrome). This combination was effective in five of six patients with proteinuria. In one recurrent case, the combination of Ba-wei-di-huangwan and Bu-in-tang (補陰湯) led to recovery. These results show that these formulas may exert a synergistic effect responsible for improvement in urinary protein excretion.

Introduction
Patients with nephrotic syndrome commonly take steroid hormones. However, some patients experience many side effects. To decrease these steroidal side effects, Chai-ling-tang (柴苓湯) was often applied [4].
Because some side effect may persist, we tried to create new herbal combination.

Material and methods
We studied eight adults and three children who were diagnosed with nephrotic syndrome at other medical facilities that followed our instructions.
A treatment was deemed very effective (+2) when more than 2 years had passed without recurrence even after quitting steroid hormones after a combination therapy consisting of four prescriptions (BXSH) in steroid refractory and dependent cases. Another very effective (+2) case is without relapse for more than 2 years who took only Kampo medicines without steroid hormone. A treatment was deemed effective (+1), only during the intake of Kampo medicines, improvement was observed in the form of a reduction in daily proteinuria of more than 50% compared to patient's condition without Kampo medicines, or when the required steroid volume was reduced. And another effective (+1) case is as follows. The patient took a combination of steroids and Kampo medicine and proteinuria disappeared within 6 months, subjective symptoms improved and no recurrence was observed in more than 2 years after steroid hormones were stopped.
We obtained these prescriptions in powder form from Matsuura Yakugyo Co, Ltd (24-21, Enjo-Cho, Showa-Ku, Nagoya 466-0054, Japan) or Tsumura Co. LTD. These powdered prescriptions are made from filtrate of decoctions followed by spray drying.
When several different prescriptions were combined to make a single new prescription for decoction, and when the same herb was used in more than two prescriptions we used the largest volume of herb. We prepared the decoction using with market boiling instrument. Kampo medicines are usually taken before meal. In cases of digestive system trouble, they are taken after a meal.

Effects to steroid-resistant nephrotic syndrome
Case 1. M.O female. First onset at age 7 Three months' steroid treatment did not work for her. At the first visit to my clinic, her proteinuria score on the paper test was +4. She showed moon face, red striae and polytrichia.
At the insistence of the patient's mother, any conventional therapy including steroid hormone was stopped and 1/2 of the adult volume of ba-wei-di-huang-wan (八味地黄丸), gui-zhi-fu-lingwan (桂枝茯苓丸) and dang-gui-shao-yao-san (当帰芍薬散) were prescribed which made her proteinuria disappear after 2 weeks.
She continued taking the same prescription for 4.7 months. At the time of the writing, more than 10 years have passed and she has had no recurrence.
Her treatment was estimated very effective (+2).
Case 2.T.K female. First onset at the age 45 ( Figure 5) Nine years of conventional therapy at other hospital brought no improve-ment in this patient's condition. When she first visited my clinic, she was taking 10 mg of prednisolone and 50mg of cyclophosphamide every other day.
When she was 59 years old, the doctor in chief stopped all her conventional therapies. We assessed her treatment was effective (+1). She relapsed five times whenever her intake of prednisolone reduced to below 20 mg/day. Betamethasone gabexate mesylate(B), and pulse therapy did not work at all. When a hematoma was produced by her kidney biopsy, her proteinuria level increased to 25g/day which then decreased with a dose of 60 mg of prednisolone/day. Cyclophosphamide was restarted at a dose of 50mg/day, and 2 months later when the patient's intake of prednisolone was reduced to 17.5g/day, no relapse occurred. And when her prednisolone was decreased to 15mg/day, she started taking BXHS mix prescriptions. After 13 months, she had no proteinuria and her intake of prednisolone was further reduced to 5mg/day. She had been taking 2.5mg of prednisolone to prevent relapse. But now more than 20 years had passed without any recurrence. We estimate her treatment effective (+1) ( Figure 6). This patient's initial proteinuria level was 10g/day with membranous nephropathy. When her intake of prednisolone decreased from 40mg/day to 5 mg/day, her nephropathy relapsed. At her first visit to my clinic, she was taking prednisolone at a dose of 15mg/day, and her proteinuria level was 2.2 g/day. After 26 weeks of intake of BXHS mix prescriptions, her proteinuria level had fallen to 0.7g/day which meant that the treatment was judged to be effective (+1). The patient was later able to reduce her intake of prednisolone to 2.5mg/day. At 3 years after discontinuing BXHS mix prescriptions, the patient recurred with a proteinuria level 3g/day despite intake of prednisolone. She was assessed to be effective (+1).   This patient suffered from proteinuria (+4 with test paper) after being vaccinated for influenza. With the full-dose administration of betamethasone, his proteinuria disappeared. But a reduction in the intake (administration on a schedule of 3-days on, 4-days off), caused his proteinuria to reappear at a level of +1 with test paper. In order to break away from the betamethasone, he began taking BXHS mix prescriptions and 2 months later his proteinuria disappeared. Twenty months after starting BXHS together with betamethasone, he stopped taking betamethasone but continued BXHS for an additional 7 months. He has had no relapse for more than 20 years.

Effects on steroid-dependent nephrotic syndrome
He will be evaluated very effective (+2).
Other cases: One male patient. First onset at age 36.
After spontaneous recovery from proteinuria, suffered a relapse (+4 with test paper) due to the aggravation of chronic prostatitis. His proteinuria level was 10 g/day and he was hospitalized. He was treated with steroid therapy which worked. To achieve steroid withdrawal, BXHS was prescribed with the goal of being protein-free. And he succeeded at 8 weeks. Three years after starting BXHS the patient's steroid was reduced to 7.5mg/day and further reduced  Complementary Therapies for the Body, Mind and Soul to 5mg and finally stopped after 22 months. Since the start of BXSH, there has been no relapse for 9.2 years. Recently, although the patient's chronic prostatitis was again aggravated, there was no relapse indicating complete recovery. He was deemed very effective (+2).

Quick start of BXHS together with steroid therapy
One of two cases, was effective. We present the effective case. Since 1 year ago, this patient was made aware of her proteinuria.
(+1~+2 with test paper) with membranous nephropathy. She was hospitalized with proteinuria (5 g/day). But it reduced to 2 g/day with 60mg/day of prednisolone. When steroidal intake decreased to 50mg, she started BXHS. After approximately 3 months' intake of BXHS, her urinary protein disappeared and she was discharged from the hospital. After taking steroid for 18 months, she stopped and remained protein-free for more than 4 years. She had been taking 1/4 of initial volume of BXHS without relapse more than 10 years. She was assessed very effective (+2).

To nephrotic syndrome cured by only Kampo medicines
Case 7. Y.O female. First onset at 50.
Proteinuria (2.7g/day) disappeared approximately 15months later after BXHS was started with a gradual decrease and then stopped after 4 years and 2 months. The patient took this medicine for more than 7 years to prevent relapse. She was deemed very effective (+2).

Appendix: Efficacy for proteinuria
We applied Kampo medicines to eight patients without postural proteinuria. BXHS worked in seven of eight patients (data not shown).

Discussion
Generally speaking, the pathology of nephropathy stems from an over permeability of the glomerular basement membrane to serum protein.
Furthermore, blood coagulation can be accelerated. Histologically, thrombosis with fibrin may be observed. The side effects of the administration of steroids for a long time include an increase in blood viscosity and platelet hyperfunction. It is quite natural for antiplatelet drugs to decrease the diapedesis of protein from the kidneys.
As mentioned above, ba-wei-di-huang-wan warms the Kidney and improve the kidney function. Huang-lian-jie-du-tang worked to remove dampness and heat and also used si-wutang to accelerate blood circulation and improving anemic tendency. I also used xiao-chai-futang because it is the component of chai-ling tang which is used to eliminate steroid side effects and for nephrotic syndrome in Japan. Additionally, it was used effectively by Otsuka and Yakazu for proteinuria and nephrotic syndrome [21,22]. I selected these prescriptions for these reasons. I will propose instead of combination of huang-lian-jie-du-tang and si-wu-tang, wenqing-tang (温清飲) will be successfully replaced. Because, wen-qing-tang (温清飲) equals combination of huang-lian-jie-du-tang and si-wu-tang.

Conclusion
The combination of ba-wei-di-huang-wan (八味地黄丸), shao-chai-hu-tang (小柴胡湯), huanglian-jie-du-tang (黄連解毒湯) and Si-wu-tang (四物湯) works to decrease the intake of steroids or helps the patients to stop taking steroids in steroid-refractory and dependent cases and for general nephrotic syndrome.

Abstract
A 41-year-old female was diagnosed with acute lymphocytic leukemia (ALL) at a university hospital. She could not tolerate chemotherapy and started alternative Chinese herbal medicine including zi-xue-tan (紫雪丹) ( Table 6) at the time of her fourth recurrence. This provided transient improvement followed by aggravation after her intake was decreased. A blood test suggested complete recovery. Although cyclophosphamide had previously been ineffective, this time together with Chinese medicine, it led to a dramatic improvement.

Introduction
Conventional therapies for leukemia have developed dramatically and now include such treatments as bone marrow transplantation (BMT). However, there remain the problems of side effects of chemotherapy, age limits for certain treatments, and a shortage of donors for BMT. Based on the clinical course of the case presented here, TCM should be considered as a potential alternative medicine treatment in some cases [24].

Case report
A 41-year-old female developed bone pain in November, 1989. She had also been suffering from constipation and cold intolerance. She reported in her family history that her mother had been suffering from rheumatism and brain embolism. After a thorough examination, the patient was diagnosed with L2 (by the French-American-British, FAB, classification) acute lymphocytic lymphoma. Chemotherapy with vincristine, prednisolone, daunorubicin, mercaptopurine, methotrexate, L-asparaginase, vindesine, and adriamycin was instituted. Complete remission was achieved and the patient left the hospital in March, 1990.
However, she subsequently suffered relapse three times. After she left the hospital in complete remission in August, 1993, 54.2% peripheral blood blasts appeared simultaneously with hair loss, nausea, diarrhea, candida stomatitis, mycotic pneumonia, and sepsis. As these side effects of chemotherapy were overwhelming, she refused all treatment at the hospital. Her family was told by the doctor that she had only 3 months to live. In April, 1994, she suffered from terrible weariness, insomnia, vertigo, and palpitations. She also suffered from inflammation of the mandibular joint (3-4 times/month) followed by difficulty in chewing food.
Lu Xi of the Lu family, noted for their treatment of acute febrile diseases (Wen bin), diagnosed her with acute febrile disease with stagnation of pathogenic heat, shortage of Qi (vital energy) and Yin including blood (xue) with blood stasis [24]. Her tongue body was pale and her lips were dark, indicating anemia and blood stagnation. Her pulse was thready and barely palpable. The patient elected to start TCM therapy on April 25, 1994.  Treatment was carried out to detoxify by supporting with Qi-tonic and Blood-tonic. The patient took prescriptions I-1, I-2, and I-3 as shown in Table 4 from April 25 to May 6, which increased her WBC to 69800/µl and decreased RBC to 204 x 10 4 /µl, Hb to 7.0 g/dl, and changed blasts from 41480/µl to 66799/µl.
Her bone marrow, evaluated by tap, showed many malignant cells. Peripheral blood findings are shown in Figure 7. Seven days after the patient's discharge from the hospital on May 26, her WBC and blast cells again increased to 52200/µl and 89%, respectively, implying worsening of the disease. This may have been caused by excessive Blood-tonic herbs. We accordingly increased her dose of modified Zi-xue-dan (Table 6) and started Ling-yang-jiao (羚羊角) on May 29. In Prescription III, Qi-tonic and Blood-tonic herbs were decreased. Kidney-tonic Yin-yang-huo (淫羊藿) and Bohuzhi (破胡紙) were added, and an-gong-niu-huang-wan (Table 7) was added to dissipate heat and detoxify. Nevertheless, the patient's high fever continued. Her WBC count increased Table 6 1. Composition of modified Zi-xue-dan written in He-ji-ju-fang ( 4 Leukemia-related disease) Table 6. Composition of modified Zi-xue-dan written in He-ji-ju-fang, (4 Leukemia-related disease) Complementary Therapies for the Body, Mind and Soul to 99800/µl on June 6 and retinal bleeding occurred with bone pain unresponsive to indomethacin for which narcotics were required. The increase in blastic cells suggests an autocrine phenomenon. Perhaps a different cell line that was suppressed by Zi-xue-dan and Prescription was activated and increased. Based on TCM theory, in prescription III, Yang-tonic yin-yang-huo (淫羊藿) and po-hu-zhi (破胡紙) were included to warm the kidneys and increase kidney function. As in bone marrow, the haemopoietic role will be carried out more with the Yang-tonic herbs.
The patient then took cyclophosphamide at doses of 50mg, 50mg, 50mg, 100mg, 100mg, and 300mg for 7days in this order, even though it had not been effective 6 months earlier. Her WBC count on June 14 had decreased to 17700/µl. During the 7-day treatment with cyclophosphamide, the patient's severe bone pain continued, but disappeared almost completely on the 8th day. She was diagnosed with gout based on clinical symptoms, in spite of normal uric acid levels. Beginning on June 23, she took granulocyte-colony-stimulating factor (G-CSF) for 7 days. Every day, approximately 2 hours after G-CSF intake, she had a fever of 39°C, which was successfully reduced by indomethacin and which resolved when the G-CSF therapy was stopped.
After 750 mg of cyclophosphamide together with TCM for just 1 week, the patient's WBC decreased to near 500/µl, with 4% blasts. This situation continued for approximately 1 month until An-gong-niu-huang-wan was stopped and other Chinese medicines were decreased to 1/4 dosage because her WBC did not increase above 1000/µl. Complete relapse was achieved. The patient's renewed sensitivity to cyclophosphamide may be the result of an interval or partially by the change in her constitution created by taking Chinese medicine.
If we do not stop An-gong-niu-huang-wan and do not decrease Kampo medicine for the time being, the patient might survive longer. Sadly, there remain few treatment options for this patient.
In conclusion, a combination therapy with traditional Chinese herbs and chemotherapeutic agents may make it possible to reduce the total quantity of chemical drugs for some time. This may be particularly useful in cases of refractory leukemia. We also experienced another case not reported here of leukemia/lympho-blastic lymphoma (LBL) in which the patient was unable to receive chemotherapy due to terrible side effects. Traditional Chinese medical doctor, Lu Gan Fu, applied Zi-xue-dan (紫雪丹) for pathogenic heat and detoxification, which was able to reduce the patient's WBC count including leukemic cells [24]. He could survive 4 years and 10 months, though before starting TCM therapy his physician in charge told his family the patient could live 2 months. Complementary Therapies for the Body, Mind and Soul 68 6. Hyperlipidemia-related disease 6

.1. Ayurvedic herb, Tinospora cordifolia
Tinospora cordifolia (Tin) is widely used in Southeast Asia as folk medicine for various diseases including diabetes mellitus (DM) [25]. In Japan, mechanism in decreasing blood cholesterol was reported in catabolism to bile acid [26].
We studied the effect of Tin in lowering blood total cholesterol (TC), triglycerides (TGs), very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) in 4 patients with hyperlipidemia. We prescribed powdered Tin at a dose of 0.75g/day for these four patients for 6 months. We examined blood TC, TGs, VLDL, and HDL before starting, once a month during administration, and at 17 days after stopping this herb.

Abstract
Tinospora cordifolia (Tin) was administered to four patients with hyperlipidemia for approximately 6 months and TC, TGs, VLDL, and HDL were measured once a month.
In three cases, on sampling in December, TGs tended to decrease (Figures 9, 10, and 11, Ayurvedic herb.Tinospora cordiforia) and subsequently kept similar level and increased after discontinuation of Tin. TCs seem to keep similar level during testing period. VLDL tend to decrease during Tin administration in Figures 9, 10, and 11. Tin seems to have some influence on the human lipid metabolism, especially in TG and VLDL. Our subject who had a family history of DM ( Figure 12) showed different patterns in TG, VLDL from cases shown in Figures  9, 10, and 11. She may have a different lipid metabolism due to a shortage of insulin action or insulin resistance with her family history of DM, which requires further clarification through continued research in this field.

Materials and methods
The four patients had all been taking their own herbal medicines for their constitutions. We tested the effect of powdered Tin without changing their regularly taken medicines including herbal medicine. For breakfast of test day, they each had a small portion of rice and some pickled vegetables, and tested at my clinic about noon, I drew blood from a vein on the left hand. Their breakfast was small and quite similar every time that blood was drawn.
She had been suffering from constipation, anal prolapse, and hyperlipidemia, and has adrenal tumor. She had been taking modified bu-zhong-yi-qi-tang (補中益気湯) for 3 years. taking modified chai-ling-tang (柴苓湯) with ba-wei-di-huang-wang (half dose/day) for more than 7 months.
Her parents had a family history of DM. She had been taking ba-wei-di-huang-wang (八味地 黄丸) and gui-zhi-fuling-wan (桂枝茯苓丸: full dose of 1 day) for more than 1 year.
We prescribed powdered Tin (regular volume, 0.75 g /day) for these four patients for 6 months. I examined blood level of TC, TGs, VLDL, and HDL before starting, once a month during administration, and at 17 days after stopping this herb. LDL was calculated as total-Cho extracted HDL plus 1/5 TGs.

Results and discussion
In Case 1, LDL showed a small increase at the initiation of Tin, but then decreased consistently even after Tin was discontinued and remained low for approximately 1 month. At 2 months after the discontinuation of Tin, however, it started to increase. TG had decreased from 152 to 83 mg/dl at 2 months after initiating Tin, and remained nearly constant until 1 month after stopping Tin. HDL increased from the beginning until 1 month after stopping Tin. In short, in Case 1, LDL and TG kept decreasing and HDL kept increasing. A high level of TC might reflect HDL concentration, which does not necessarily mean bad hyperlipidemia. For her Tin seemed to play a good role to decrease the level of TG, LDL and increase of HDL ( Figure 9). In Case 2, from October 7 till November 28, TC, LDL, and TGs all decreased. However, early in the new year, the patient ate her favorite herring roe every day. At January 7, TC and LDL had increased while TGs kept decreasing. The patient's LDL level at 20 days after stopping herring roe had decreased slightly. The intake of herring roe did no influence to the ability of Tin to decrease TG levels. But after stopping Tin, TG, VLDL, and TC similarly increased which implies that Tin can decrease TG levels. In this case Tin did not influence HDL level ( Figure 10). In Case 3, TC, LDL, and HDL all tend to increase until second sampling, and then increased again after Tin was discontinued.
Until the time of the third sampling, the patient had been taking antibiotics for inflammation associated with otitis externa, which would have influenced her lipid metabolism. After stopping Tin, all levels increased. This may mean that Tin can decrease the blood levels of TC, LDL, VLDL, and TG. But I cannot explain why LDL increased at the beginning of Jan-uary. The patient's TG level tends to remain same normal level ( Figure 11).
In Case 4, unfortunately, three spots could not be measured for her private reason, but it is clear that, from January until the time when Tin was continued, all factors increased except HDL and that after Tin was discontinued, they all decreased. This implies that Tin was not effective in decreasing blood levels of TC, LDL, VLDL, or TGs in this case. We therefore recommend that this patient should take conventional medicine for hyperlipidemia ( Figure  12). Her family history of DM may play a role in this phenomenon and must be further clarified. Finally, except Case 4 with family history of DM, Tin tends to decrease the level of TG and VLDL and tend to increase HDL in Case 1 and 3.
Finally, Tin may play a role to decrease human hyperlipidemia in TG and VLDL level, which must be clarified about the mechanism in future.

Case 2:
A 60-year-old Japanese female, 152 cm tall and weighing 54 kg, who refused conventional therapy had been taking ba-wei-di-huang-wan (八味地黄丸: full dose/day) with powdered type of extract of zhi-gan-cao-tan (炙甘草湯) and xiao-chai-hu-tang (小柴胡湯) together with guizhi-fu-ling-wan (桂枝茯苓丸) because unless she take these prescriptions her fasting glucose level increase above 150 mg/dl. When her TG level surpassed 800 mg/dl in December, 1987, we prescribed modified dan-dao-paishi-tang (DDPT) without changing the medicines described earlier, and her TG level had decreased to 450 mg/dl by April 1988. As she suffered from appetite loss, stomach fullness and loose stool, her intake was reduced to 1/6, which led to 735 mg/dl in May 1989. She repeated the pattern of a high dosage of DDPT followed by a low blood TG level, then digestive system symptoms, then a lower DDPT intake followed by high blood TG. Finally, she persisted in taking only a small amount of DDPT, which led to an increase in TG. TC showed a similar tendency to TG, but was not so conspicuous as TG in this patient. These results may be related to the patient's DM condition and/or to the fact that she did not excise regularly and was on no specific diet ( Figure 13).

Discussion
In Case 1 and 2 and two other cases (data not shown), DDPT was able to decrease TG levels.
In Case 2, DDPT seem to work dose-dependently. Unless the digestive system is weak, DDPT can be used without complications. Of course, exercise is required with herbal medicine. It has been suggested that DDPT may promote the secretion of bile acid, which promotes lipid absorption. If this were the case, blood TG levels should be elevated; but in fact the opposite occurs. Further study is required to clarify the actions of DDPT.

Abstract
It takes a long time to recover from sprains, bruises, and arthritis, which often involve both pain and a decline in QOL. We applied two Kampo medicines, zhi-da-pu-yi-fang (治打撲一方: remedy for contusion) (Tsumura & Co. 7.5 g/day) to resolve inflammation and restore injured parts ("dampness-heat" in TCM), and Ba-wei-di-huang-wan (八味地黄丸) to restore presumed minute bone injury and to regulate metabolism (kidney tonic in TCM). We treated sprains, bruises, and arthritis in 10 patients (40-85 years of age; 1 male, 9 female) using the visual analog scale (VAS) to assess pain in the affected body parts before and after the administration of Kampo medicines. In almost all cases, recovery began promptly and pain disappeared within approximately 2 weeks. Large doses for a short time seemed to achieve quicker recovery [28].

Bruises
Case 1: A 67-year-old Japanese female was involved in a traffic accident and suffered bruising of the left hip without bone fracture. The two prescriptions were started immediately. At seven days, her VAS score had improved to 2 from 10. She was completely pain-free 28 days after the accident (Figure 15).

Sprain
Case 2: A 72-year-old Japanese female with osteoporosis and rheumatoid arthritis sprained her right ankle and was treated with the conventional therapies for 1 month without any improvement to her VAS score of 9. After initiating Kampo medicine, her pain disappeared completely after 14 days ( Figure 16).

Arthritis
A 72-year-old Japanese female had been treated with conventional therapies for more than 6 years without stable recovery. After taking Kampo medicines for 14 days, she reported no pain ( Figure 17).

Discussion
Among components of 治打撲一方, gui-zhi (桂枝: Chinamomi Cassesiae) and ding-zi (丁子: Caryophylli Flos) promote blood circulation, and chuan-xiong (川芎: Ligustici Chuanxiong Rhizoma) accelerates blood circulation and blood stasis. In a Japanese clinical study, chuangu (川骨: Nupharis Rhizoma) was found to stop bleeding and accelerate the reabsorption of bleeding in the body. Da-huang (大黄: Rhei Rhizoma) removes substances produced by a resolving hematoma and other affected parts, which accelerates hematoma resolution. Po-su (樸樕: Quercus Cortex) is thought to have detoxifying, antiphlogistic, and astringent properties. Gan-cao (甘草: Glycyrrhizae Uralensis Radix) regulates and harmonizes other herbs. With Bawei-di-huang-wan (八味地黄丸), it serves as a kidney tonic and accelerates the bone metabolism, which supports the recovery of injured parts with two prescriptions (Tsumura & Co 7.5 g/day).

Abstract
The intake of hot water extracts including Ganoderma lucidum or WTMCGEPP (Wisteria floribunda 0. 38 Additionally WTMCGEPP increased NK cell activity during intake of for 3 months in 4 females (mean: 51years) and in 9 weak infants who are outpatients of university hospital (data not shown).

Case 1:
This patient was 158 cm tall and weighed 65 kg. Several days prior to his consultation, he had been on a bus tour and suffered lack of sleep and fatigue. On day 1, he felt pain on the left sinciput of his face. Vesicles appeared and the left half of his face was swollen with pain at a verbal descriptor scale (VDS) level of 1. His pain increased day by day and reached VDS 5 on the 6th day. He was diagnosed with shingles at a local hospital. Neither antiviral ointment nor anti-inflammatory medicine worked, and his pain increased to VDS 6. By day 8, the pain was intense and the patient's left eye was swollen shut with mucus and deteriorating skin lesions. When he visited us with VDS 9, we prescribed 5 doses per day of WTMCGEPP. After 2 days of administration, his pain started to decrease and his swollen face and eye improved enough that he was able to see clearly ( Figure 18). Even though his doses were reduced, his pain continued to decrease, soon reaching VDS 2. By day 12, the patient's rhinorrhea had decreased significantly. On day 18, he achieved complete recovery with a VDS score of 0. At the time of writing, he has been pain-free for more than 10 years. Herbs composing WTMCGEPP was obtained from Tochimoto Tenkaido Co, Ltd.

Case 2:
The patient was a 17-year-old Japanese female (165 cm, 54 kg) with acute herpes zoster otitis. She had become very tired due to lack of sleep while studying very hard for exams for 5 days before the onset of this pain. As she felt severe right ear pain, she visited an otolaryngologist, who diagnosed her with acute herpes zoster otitis and recommend starting conventional therapy immediately. However, she refused this treatment because her grandmother insisted on taking herbal medicines and requested WTMCGEPP therapy, which she started (6 doses per day) on the 3rd day from the onset of pain ( Figure 19). The pain gradually decreased 3. WTMCGEPP worked in a weak infant suffering from infections related to Epstein-Barr virus (EBV), cytomegalovirus (CMV), and/or herpes simplex virus that required repeat admissions to the hospital [30,31].

i.
A 5-year-old boy with EBV and CMV infection suffering from frequent bronchial asthma and chronic bronchitis with fever was not cured by conventional therapy, but was cured by WTMCGEPP.

ii.
A 6-year-old Japanese girl with herpes labialis suffered pain during eating which disappeared after 3 days of WTMCGEPP treatment.

iii.
A 60-year-old man with herpes genitalis felt an unpleasant sensation with genital pain when he was tired. After intake of WTMCGEPP for several days, the pain disappeared. WTMCGEPP is a good choice for this patient because he seemed to develop tolerance for antiviral drugs.

iv.
WTMCGEPP works herpes labialis and herpes genitalis very well. But patients with leukemia or lymphoma do not want to take it. Because of a feeling of wrongness. Of course, I never prescribe WTMCGEPP to them. I wish to study to find the reason.

4.
In Japan, for patients suffering from hepatitis C, many Kampo medicines are applied. I often added WTMCGEPP not to progress to liver cancer, which seems relatively effective [32].

Glossodynia-related pain
Glossodynia is often difficult to cure with conventional therapies, but some Kampo medicines have been reported to be effective. I present one case here [33].

Case 1:
A 74-year-old Japanese female (height, 150 cm; weight, 35 kg) suffered from sore tongue and appetite loss with atrophic gastritis since 1 year ago. She had had alopecia 5 years previously. On September 20 (X year), both sides of her tongue were reddish and rough. By October, her tongue was sore all over without fur (mirror tongue).
All treatment at a national hospital failed to improve her condition. One dentist recommended that she receive Kampo treatment. At her first visit to my clinic, she was diagnosed with Yin deficiency of the Heart and Spleen, Kidney Yang deficiency, Liver Qi depression tending to transform into fire based on oral dryness and heat, constipation, aversion to the cold, dry skin, depression and insomnia, a reddish tongue body without fur, dark sublingual vessels and string-like, slippery and sunken pulse.
Three days later, she telephoned to tell me that her tongue pain had decreased dramatically, and on December 10 her tongue and stomach were pain-free, suggesting that her tongue pain stems from Yin deficiency (Fig.20).  improvement in the frequency and severity of seizures. This treatment will rely on the resolution of blood stagnation in cerebrovascular systems [36].

"Five Elements Theory" must be applied to get the treatment
When we treat patients with various symptoms, we usually treat for severest symptoms like cough, with mai-men-dong-tang. This is for Lung. But sometimes prescriptions for lung did not cure cough at all. Example is shown below.
When patients suffering from chronic cough and various Kampo medicines for the cough do not work. To this case I apply "Five Elements Theory".

1.
One 72-year-old female suffer chronic coughing. Her coughing started when she started to feel cold and get sensitiveness to cold probably because of her aging. I thought her aged Kidney deprive vital energy of lung which will cause her chronic cough. Actually, administration of ba-wei-di-huang-wan (八味地黄丸) stopped coughing after intake of 1 month.

2.
Another case of diarrhea (38-year-old) which continued more than 3 weeks which did not response to various Kampo medicines for digestive system. I thought this diarrhea would be the result of Liver overwhelm the Spleen. I prescribed jia-wei-xiao-yao-san (加味逍遥 散) to suppress Liver. A week later her diarrhea almost disappeared [37].

Application of Gui-zhi-fu-ling-wan (桂枝茯苓丸) for the diagnosis of breast cancer in diagnostic hormonal therapy
In spite of improvement in imaging technique for breast cancer, many latent microcarcinomas go undetected. Diagnostic hormonal therapy with antiestrogens may induce terrible side effects in some patients. Thus, excisional biopsy is required for an accurate diagnosis of malignancy.
Gui-zhi-fu-ling-wan (桂枝茯苓丸) has been effective in treating mastopathy and has almost no side effects. Thus, we tested its use as an alternative to antiestrogens. Gui-zhi-fu-ling-wan was administered to 116 patients out of 218 with mastopathy. Four were suspected to have breast cancer and were later definitively diagnosed with breast cancer, two by fine-needle aspiration cytology and two by excisional biopsy. Gui-zhi-fu-ling-wan proved to be useful in the diagnostic hormonal evaluation of mastopathy and in the diagnosis of breast cancer [38].