Methods of research on spirituality in organizations. Source: Heaton et al. [25].
\r\n\tIn this book the authors will provide complete introduction of Polymers chemistry. The book is mainly divided into three parts. The readers will learn about the basic introduction of general polymer chemistry in the first part of the book.
\r\n\tThe second part of the book starts with a chapter which includes kinetics of polymerization. Polymer weight determination, molecular weight distribution curve and determination of glass transition temperature. The final part of the book deals polymer degradation which includes types of degradation. The chapters of the present book consist of both tutorial and highly advanced material.
Small and medium enterprises (SMEs) are considered as the backbone of a country because they are related to every aspect of economic and community life. SMEs are also seen as growth engines for economic and social transformation in a country. Nevertheless, there are real limitations faced by SMEs including insufficient employees, lack of financial resources, lack of experience and educational background, and lack of managerial knowledge.
The contribution made by SMEs reaching the micro and macro levels cannot be separated from the successful management of SMEs by effective leaders [1]. The leadership behavior or style of SME leaders is a key element and has a direct influence on organizational performance, competitive advantage, and the success of SMEs [2]. According to Avolio et al. [3], leadership plays an important role in organizational development and growth. Organizational leaders generally consider all business plans and decisions in an effective and timely manner. Leadership becomes more important when faced with new or changing situations. Various micro, small and medium enterprise (MSME) literatures have shown that weak and insufficient leadership skills are a major factor in the failure of SMEs. Therefore, SMEs need to develop their leadership behavior to bring the company through all situations, both calm and crisis.
Over time, the concept of leadership has been discussed and studied in a variety of different theories, approaches, and styles [4, 5]. However, there are no universally accepted concepts and definitions due to differences in organizational forms and contexts [6]. It is also not easy to define the concept given the size of the subject and the general conventions about field analysis.
Earlier Bass [7] states that the definition of leadership is closely related to the efforts of various possibilities. While Hirtz et al. [8] stated that leadership is a process by which managers for the purpose of directing their subordinates in order to work toward the company. The concept of leadership is also with stimulants and motivations that motivate people to achieve together [9]. This is in line with the statement of Hersey et al. [10] that the essence of leadership involves purpose through people.
Meanwhile, there is one concept called spiritual leadership that is rarely implemented, but it is crucial to be applied by the small and medium enterprises, which usually have a limited number of employees. How this concept could be applied? This would be questioned, and thus, this study aims to explore the application of spirituality leadership in small business. Moreover, this chapter will discuss the essence of leadership, the spiritual leadership theory, antecedents of spirituality in organizational behavior, spiritualism in modernity content, and conclusion.
Leadership can be seen as a group process, personality attribute, art of encouraging gratification, exercise of influence, certain types of actions or behaviors, forms of persuasion, power relations, and instruments for achieving goals [7, 11]. According to Kotter [12], without leadership, the possibility of mistakes will increase and decrease the chances of success. Leadership enables collaboration, reduces conflict, contributes to creativity, and plays a role in integrating people even if not physically. Alas et al. [13] also look at leadership in terms of individual traits, leader behavior, interaction patterns, role relationships, follower perceptions, influence on followers, influence on task goals, and influence on organizational culture. This view focuses on the relationship between leaders and followers, but not on what conditions must exist for an effective leader to emerge or develop [14].
Kouzes and Posner [15] emphasize leadership issues on leadership methods, how to build and articulate a vision and values, develop strategic awareness and approach to team building. Specifically, the five leadership practices highlighted by Kouzes and Posner [15] are as follows:
Model the way—lead by example;
Inspire a shared vision—paint a clear picture for everyone to see and understand in achieving the organization’s future visions and dreams; belief and ambition; and the importance of dialog;
Challenge the process—change from the status quo and innovation (finding and enhancing product and service innovation opportunities; creating the right climate; anticipating risks and uncertainties);
Enable others to act—the team effort required to achieve the vision by building trust and strong relationships and encouraging collaboration of all stakeholders;
Encourage the heart—the importance of acknowledging contributions, appreciation; a culture of celebrating values and victories; and its relation to performance.
Leadership practice is often associated with the applied leadership style. However, the rapid changes in the environment, communication technology, and the development of community paradigms require the application of a leadership style that is in accordance with these changes. One option in solving these problems is a transformational leadership approach. Transformational leadership is comprehensive and integrated leadership ability for individuals, groups, and organizations to produce transformations marked by changes at every stage of activity. Transformational leadership is developed to deal with change by transforming individual paradigms and values within the organization to achieve organizational goals and vision.
Transformational leadership was first proposed by Downton [16], which was later developed by a sociologist in the field of politics, Burns [17]. Burns [17] connects the role of leadership with followers. As a leader, the task of a leader is to encourage the enthusiasm of his followers to achieve common goals. Transformational leadership has characteristics that emphasize intrinsic motivation and the development of followers [18]. The aspects of transformational leadership are characterized as follows:
Transformational leadership arises when members in the organization (leaders and followers) want high motivation and morality. This condition can arise when the organization is facing competition or a lot of customer dissatisfaction.
Transformational leadership seeks to motivate and inspire those around them by explaining the urgency of work and challenges. How to motivate this can be done with various approaches such as the needs theory approach, namely the fulfillment of the main needs of followers such as physical, security, social, esteem, and self-actualization needs. In addition, the creation of justice in the permanent system contributes in advancing the organization. Meanwhile, in terms of generating inspiration, it can be done through evaluation of the failures and successes that have been achieved in order to encourage the learning process through discussions, literacy studies, comparative studies, and so on.
Transformational leadership is able to reduce the dependence of followers on their leaders. This can be seen through the delegation of authority, developing the ability and confidence of followers, as well as encouraging flexibility in the implementation of teamwork, providing direct access to information, eliminating unnecessary control functions, and creating and empowering a strong work culture.
Transformational leadership develops visionary thinking.
Transformational leadership develops a collaborative way of working rather than a hierarchical way of working through individual learning and organizational learning. The collaborative way of working results in greater performance than the performance that results from individual systems.
Transformational leadership encourages the empowerment of followers so that they are appropriate in dealing with developments in situations and environments that affect the organization.
In addition to transformational leadership, there are other leadership styles that can also be applied in organizations including MSMEs, namely transactional leadership. Transactional leadership is known as a leadership style that motivates and encourages obedience by followers or subordinates through rewards and punishments. With this system the leader can keep subordinates motivated at least in the short term. This leadership style often occurs when someone takes the initiative in making contact with others to exchange things of value [19]. Bass [7] also revealed that transactional leadership is characterized by the provision of assessment through rewards, recognition, salary increases, and career advancement for members who perform well and vice versa, namely the provision of punishment for poor performers. Therefore, transactional leadership is often considered effective in achieving organizational goals [20].
Literally, transactional means “a transaction or exchange.” Transactional leadership is concerned with exchanges or transactions between leaders for the desired result by fulfilling the desires of the leader and the expectations of followers, which involves a promise or commitment and trust. Transactional leaders also accommodate the interests of their subordinates by providing incentives, honors, and promises to subordinates who have successfully fulfilled the commitments of leaders or organizations. Transactional leadership is able to encourage followers to perform in accordance with the wishes of the leader in the hope of obtaining rewards and rewards. Transactional leadership also facilitates subordinates to recognize obligations for work and goals to be achieved [21].
Sedarmayanti [22] classifies transactional leadership into:
Contingent reward, namely the leader will influence the behavior of subordinates by providing details of the work to be done to subordinates, with incentives as motivation to subordinates to achieve the results of the implementation of tasks;
Management by exception, namely the leader will influence the behavior of subordinates by using correction or punishment efforts as a consequence of decreasing performance from predetermined standards. In addition, the leader also influences the behavior of subordinates by actively monitoring the work done by subordinates and by corrective efforts to ensure that work is carried out and completed according to standards.
The spiritual dimension in leadership studies produces a concept referred to as spiritual leadership. For the first time, the phrase “spiritual leadership” was used in an article titled “Spiritual Leadership: Meeting Whole-Self Needs at Work.” Several studies have stated the importance of spiritual values in organizations. Spiritual values in leadership are able to motivate and inspire employees in building the vision and culture of the organization and create employee commitment to the organization, which in turn also has an impact on increasing job satisfaction and employee performance. Spiritual leadership theory represents a paradigm shift in the study, research, and practice of leadership that can expand transformational and charismatic theory through ethical and value-based perspectives. According to Fry [23], spiritual leadership includes the following tasks:
Developing a purpose that inspires members of the organization to feel called, find significance, and make a difference in their lives.
Developing an altruistic love-based social/organizational culture in which leaders and followers truly care about, care for, and respect one another, resulting in a sense of belonging, being understood, and being appreciated.
There are several concepts about this spiritual leadership style [23], including:
A causal model of spiritual leadership in which an internal motivation model incorporates vision, belief, compassion for fellow human beings, application of spiritual theory at work, and spiritual endurance, as well as organizational results such as dedication and productivity.
Spiritual leadership as a collection of beliefs, attitudes, and behaviors that is inherently necessary to inspire one another in order for them to experience spiritual endurance via calling and membership.
Integrating Horton’s continuity of God as the supreme force with Smith’s perspective that all faiths embrace the vision and fundamental virtues such as humility, compassion, and honesty, the theory of spiritual leadership is able to explain how leaders and followers can be satisfied in their need for spiritual endurance.
Spiritual leadership style in building organizational culture can be done in four steps as follows:
The true intention is to build excellent inner qualities in leading, so that the organizational community will have full attention and
Developing a quality culture by building core beliefs and core values to the community that life and work are essentially worshiping God, so they must be done as well as possible.
Develop brotherhood among community members, so that synergistic cooperation between individuals and groups within the organization can be created to empower maximum potential.
Develop ethical behavior at work through the cultivation of gratitude and patience in carrying out the mandate.
Ubaydillah in Muajiz [24] defines spiritual intelligence with intelligence that elevates the function of the soul as an internal device that has the ability and concern to see the meaning behind the reality as it is. Spiritual intelligence is closer to the enlightenment of the soul. Heaton et al. [25] suggested a distinction between two constructs in spirituality, both pure and applied. Pure spirituality refers to an inner experience of pure self-awareness that is quiet and boundless, general praise of perceptions, thoughts, and feelings. An example of pure spirituality in Eastern culture is the technique of meditation. The term “applied spirituality” refers to the source of practical wisdom application and the result of which automatically arises from genuine spirituality’s experience (Figure 1; and Table 1).
Spirituality representative schemes in management literature. Source: Pandey et al. [
Subjective approach | Objective approach | |
---|---|---|
Pure spirituality | Direct personal experience of silent awakening | Psychological relationship of personal experience on reality |
Spirituality Applications | Personal reflection on the consequences articulation which considered conditions of the higher states of consciousness | Quantitative and qualitative research on physiological, psychological, organizational, and social variables before and after transcendental reality |
Spiritual Development | Reflection on and articulation of one’s development process | Quantitative and qualitative research on psychological and social development |
Methods of research on spirituality in organizations. Source: Heaton et al. [25].
The Spirituality Research by Pawar [27] draws from various literatures that can reflect various attentions on spirituality in the workplace, namely:
Spirituality in the workplace is a critical topic that has significant and prospective implications for the well-being of people, organizations, and society [28].
Scientific research has the potential to make major contributions to the field of organizational science [29].
De Klerk [30] observes about level of attention on spirituality in the workplace and clarifying the notion of the importance of motivation, which no longer necessary. He also places more emphasis on discussing toward spirituality more deeply. Pawar [27] also identified various recent studies on spirituality in the workplace that have different concerns, namely:
Focusing on the definition and operationalization of spirituality in the workplace [31, 32, 33, 34].
Provide a profile of the area of spirituality research in the workplace, and provide an outline guide to the direction and methodology of studies on spirituality [35, 36, 37, 38].
Describe the manifestation of spirituality at work in organizations [39].
Describe various organizational views that may facilitate spirituality in the workplace [40].
Identify different organizational characteristics, such as culture [41], leadership [23], and organizational practices [42], which may aid in the application of spirituality in the workplace.
Concentrating on the workplace effects of spirituality such as work attitudes [43], organizational productivity [44], and unit performance [45].
It is not easy to find empirical research on spirituality. Most of the writings on spirituality still revolve around the concept and methodology of spirituality. Two empirical studies that discuss spirituality are identified. The first is the study of Kolodinsky et al. [46], and second is Muajiz’s research [24]. These two studies represent research abroad and research within the country. While Kolodinsky et al. [46] conducted an empirical test of the effects of spirituality in the workplace.
Muajiz’s research [24] examines the effect of auditor training, emotional intelligence, and spirituality on auditor performance at the Directorate General of Taxes. The results showed that training, emotional and spiritual intelligence had a significant positive effect on the performance of auditors either partially or simultaneously. Spiritual intelligence has the greatest influence compared with the other two independent variables. However, the three variables above only have an effect of 23% on auditor performance while 77% are influenced by other factors not examined.
Muajiz’s research [24] divides spiritual intelligence into three dimensions:
Dimensions of spiritual ± religious relations, with indicators/questions:
Love of God
Better life motivation
Self-understanding as a spiritual being
Be bold in the truth
The feeling of always being watched by God
Patience
Social±religious relations, with indicators/questions:
Contribution to the welfare of others
Family ties between people
Love for living things
Ethics ± social, with indicators/questions:
Adherence to ethics and morals
Amanah (keep promises)
Can be trusted
Tolerant of difference
Anti-violence
Match between words and actions
Pawar [27] states that there are four concepts as the forerunners of the concept of spirituality in organizations that have a concern for transcendent self-interest as discussed in spirituality in the workplace. The four concepts that have preceded spirituality are transformational leadership, organizational citizenship conduct, organizational support, and procedural fairness, all play a role in the workplace. These four concepts have emerged a decade earlier than spirituality in the workplace. Workplace spirituality emerged in the 1990s, while the four concepts described above emerged in the 1980s. This demonstrates that these four ideas are pioneers of workplace spirituality, as well as providing different explanations for the research of spirituality in the workplace, and also assisting the discussion of spirituality at work in the broader study of organizational behavior. However, the four preceding concepts are not the cause of the emergence of spirituality in the workplace. Transformational leadership is the leader’s capacity to inspire and encourage subordinates to accomplish more than expected and for higher internal benefits. This kind of leadership encourages followers to strive for transcendental objectives rather than self-interest and toward self-actualization rather than just pursuing stability. Below are the elements of the concept of transformative leadership [47]. The five factors are:
Charisma, where the leader is able to gradually instill values, respect, take pride in yourself, and express a vision.
Individual attention, which prioritizes employee requirements and offers beneficial initiatives for subordinates’ personal development.
Intellectual stimulation, in which the leader assists his subordinates in reassessing the issue rationally (encouraging subordinates to be creative).
Conditional reward, in which the leader instructs subordinates on how to get the reward they want.
Management by exception, where it is possible to allow work to be done without intervening unless the task is not completed on time and at a reasonable cost.
The term “organizational citizenship behavior” (OCB) was coined in 1983 through a study conducted by Bateman and Organ and also by a Smith study in the same year. This is based on what Organ said that measuring employee performance may not cover the overall performance that he actually does [27]. In other words, it does more than what it is supposed to do. This is done because it is driven more by an internal motivation called self-transcendence, rather than personal gains. Five aspects of OCB exist: altruism, conscientiousness, civic virtue, sportsmanship, and politeness. These dimensions represent the many ways in which workers pursue profit is not just to collect values and direct rewards for themselves. This shows that the concept of spirituality in the workplace seems to share the concept of employee transcendence in the OCB concept.
According to Eisenberger et al. [48], the notion of perceived organizational support reflects that organizations are concerned with employee values, well-being, and contributions. If employees perceive organizational support for them, then they will also provide benefits for the organization. This is called the norm of reciprocity, one party will repay the kindness of the party who has given him kindness as well. To a certain extent, this is also related to self-transcendence as well as spirituality in the workplace. This is proven by empirical results, where perceived organizational support has a significant effect on lower absenteeism and employee innovation behavior. This perceived organizational support consists of operational items referring to such things as hearing employee concerns, providing assistance when employees experience problems, and will not be replaced by other employees because there are other people who can replace them with cheaper salaries. From these indicators it appears that the organization is trying to give a sense of being part of the organizational community. Being part of an organizational community is one aspect of spirituality in the workplace and reflects self-transcendence [27]. The concept of procedural justice (perceived fairness) and the procedures used to make this procedural justice are self-interest models and group-value models [27].
According to the self-interest model, the presence of fair processes guarantees that people’s personal interests and desired outcomes are safeguarded. While the group-value model argues that individuals will follow the interests of their groups in order to accept the group toward themselves so as to have a psychological impact on their identification as part of the group. This can be seen as meeting the needs of the employee community with a sense of being part of the community. Therefore, procedural fairness may be seen as a means of ensuring a sense of belonging to the community. So that procedural justice can facilitate the self-interest of employees’ transcendence. Therefore, the concept of procedural justice in the study of organizational behavior is connected to workplace spirituality [27].
Spiritualism is not synonymous with religion, but has views and doctrines similar to or close to religion. It is said that spiritualism is a philosophy, doctrine, or (sort of) religion that emphasizes the spiritual aspects of everything. So the basis of spiritualism is the view that spirit is the essence of life and that the spirit is (eternal) and not destroyed by the death of the body or by body. Spiritualism is a religion for people who do not embrace it as religion formally, but at the same time emphasized that belief (spirituality) is based on belief religion.
Now when modern humans want spirituality and meanings of deeper life, they separate it from the things that are underlying spirituality, namely religious rules. Freeing spirituality of religion and science is an act of which both will lead to emptiness and inequality. Because spirituality without the ultimate goal of the Creator has only become a psychological spirituality that will arrive at a state of emptiness, calm, peaceful but no relative and practical things, which benefit others.
According to Comte [49], in the modern society, the religion becomes abandoned. But in reality this opinion is not entirely true. The modern society actually makes people are looking for spiritual values for themselves. Spirituality in fact is not only always related to religion and God, but spirituality also functions as a psychological solutions, obsession, or temporary spiritual need for some of them. Their curiosity about what spirituality is, they only use as a solution to a problem that they cannot deal with only with a ratio but requires their knowledge of their spirituality.
The high passion for the world of spirituality cannot be separated from the construction of modernity. Modernity offers a life of luxury and ease of living for humans, but this kind of life makes people seem to have lost direction and purpose of spirituality in their lives. Modernity makes them finally looking for a spirituality within themselves. This is due to a lack of knowledge about spirituality. They do not seem to find satisfaction in themselves because of their lack of spirituality even though they have a good life with an abundance of luxury and seem to have an easy life.
Spirituality does not only refer to the meaning of religion and God, but spirituality also refers to several aspects, such as referring to nature. Human awareness to restore a natural beauty, which is increasingly being eroded due to the rapid development of modern times. Human awareness of spirituality with nature will make the nature become beautiful again as in previous times. The awakening of spirituality is very much needed in this modern era in order to be able to rebuild what has been damaged and what has been lost due to the development of modern times.
The spirituality gives another view in the process of decision-making. Spiritual leadership’s goal is to instill the beliefs, attitudes, and behaviors necessary to inspire oneself (intrinsic motivation) and others in order to attain a feeling of spiritual survival as well as to create vision and harmony of values through individuals, empowered teams, organizational levels and assist development in terms of psychological welfare and organizational commitment. While a spiritual leadership style refers to a person who occupies a leadership position must be able to increase the effectiveness of his leadership with high ability to use a situational style, which means a different style in different situations and conditions.
The SMEs will receive benefits on the leaders’ role in their organization. Leaders could have 2–3 followers as it exists in the small business, but leaders could manage more than three followers. However, leading few people is easier than many people. In other words, the leaders in small business must be able to influence others to achieve the business goals easily and faster. The essence of leadership in SMEs is shown obviously, and it is would be an important factor to control the SMEs to obtain stability or continuity in their business operations. Leaders are not managers, thus their contributions are helpful to have better performance.
This study expectedly will add literature on leadership context as well as the spiritual leadership. Practically, the application of the spirituality leadership is real and adaptable. It is not always to be associated with the religion teachings but beyond that, it is applicable in various types of organizations particularly the small business. However, a real case in an organization and empirical study is needed to be conducted to see all elements of spiritual leadership play their respective roles.
Crohn’s disease (CD) is an inflammatory disease of the gut, it and ulcerative colitis is called inflammatory bowel disease (IBD). The etiology of CD is unknown that related to genetics, environment, humoral immunity and cellular immunity to some extent. It may be due to the complex interaction between genetic susceptibility, environmental factors, and changes in intestinal microflora, resulting in mucosal immune response abnormalities and impaired epithelial barrier function, giving rise to congenital and adaptive immune response disorders [1, 2].
CD is a proliferative disease that runs through all layers of the intestinal wall and it can occur anywhere in the gastrointestinal tract, the most common being the terminal ileum and colon [2, 3]. CD has various clinical manifestations, mainly characterized by diarrhea, mucous pus and blood stool, accompanied by abdominal pain, tenesmus, fever, anemia, nutritional disorders and other systemic symptoms of varying degrees. It can also be accompanied by joint, skin, eyes, oral mucosa, liver and other extraintestinal lesions, or cause perianal lesions, intestinal obstruction, gastrointestinal bleeding, perforation and other complications [4]. This disease is mainly divided into inflammatory stage, stenosis stage and perforation stage, patients usually develop from inflammation to stenosis or perforation [3]. At present, the global incidence of CD is on the rise, and the onset age is mostly between 20 and 40 years old, with no significant gender difference [5]. CD has prolonged course, repeated attacks, and not easy to cure, which seriously affects the quality of life of patients, and aggravates the social and economic burden. Therefore, it urgently needs to be solved and further studied.
In 2012, the Inflammatory Bowel Disease Group of Gastroenterology Branch of Chinese Medical Association formulated The Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease, which standardized the clinical diagnosis and treatment of CD. In recent years, with the increasing incidence of CD, in order to meet clinical needs and better guide the clinical work, the staff of the Inflammatory Bowel Disease Group of Gastroenterology Branch of Chinese Medical Association, finally revised the 2018 edition of The Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease after extensive discussions.
As the etiology of CD is unknown, there is no radical cure at present and the side effects of drugsare obvious in some CD patients. However, the advantages of Traditional Chinese medicine (TCM) in CD treatment are gradually emerging. With the in-depths of research on CD, more and more TCM doctors and scholars have summarized the etiology and pathogenesis, TCM classification, syndrome differentiation methods and treatment principles, and summarized the characteristic treatment methods of TCM, providing the diagnosis and treatment ideas and guidance for the understanding and treatment of CD.
The diagnosis of CD depends on a combination of symptoms, endoscopy, radiology, and histopathological findings. Colonoscopy and mucosal biopsy are usually the main methods. A history of smoking, family history, gastrointestinal infection, malnutrition or anemia are all factors that should be taken into account when making a diagnosis [1].
The clinical presentation of CD depends on the site of pathological changes and the severity of inflammation, which can be divided into four aspects [6]:
(1) Digestive system performance: Spasmodic pain in right lower abdomen or peri-umbilicus, accompanied by borborygmus, aggravation after meals, it can be alleviated after defecation; diarrhea intermittent attacks in early stage, and more persistent in later stage. If the lesions involve the lower colon or rectum, mucinous blood stool and tenesmus may be present. Abdominal mass occurs in the right lower abdomen and around the umbilicus, mostly caused by mesenteric lymph node enlargement, internal fistula or local abscess formation. (2) General performance: Patients with intermittent low or moderate fever, a few show remittent fever, accompanied by toxemia; Nutritional disorders due to anorexia, and chronic diarrhea, including emaciation, anemia, hypoproteinemia, vitamin deficiency, calcium deficiency, osteoporosis, etc. The balance of water, electrolyte, acid and base is disturbed in acute stage. (3) Extraintestinal manifestations: Some patients have iridocyclitis, uveitis, finger pestles, arthritis, erythema nodosum gangrenous pyoderma, oral mucosal ulcer, chronic hepatitis, small bile duct peripheral inflammation, sclerosing cholangitis and so on. Amyloidosis or thromboembolic disease can be seen occasionally. (4) Perianal manifestations: Fistulas, fissures, abscesses, and stenosis around the anus or rectum [7]. It even affects the organs outside the gut.
Colonoscope is the most sensitive method in the diagnosis of CD, which can improve the accuracy of clinical diagnosis and the efficiency of treatment [8]. Under endoscopy at the early stage of the disease, 2 ~ 3 mm diameter round shallow pitting ulcers or Afta aphthous ulcer can be seen with surrounding mucosa hyperemia and redness. After the disease progresses, the ulcer increases and deepens, and merges with each other to form longitudinal ulcer. The relatively specific endoscopic manifestations include cobblestone changes, annular, multiple, segmental stenosis, and inflammatory polyp hyperplasia. Capsule endoscopy is very sensitive to the judgment of abnormal mucosa, but its specificity is low, and it is not applicable to all CD patients. For patients with stenosis, there is a certain risk. Wireless video capsule endoscope has the advantages of no radiation, no pain, no sedation, easy outpatient use and high patient satisfaction. When traditional diagnostic tools such as endoscope cannot make a clear diagnosis, it can be mainly used. During the development of CD, some patients may involve the upper digestive tract. This type of CD usually presents insidiously without obvious symptoms. Gastroscopy is often used, under which worm etched ulcer, longitudinal ulcer, slub like appearance, stenosis and fistula can be seen [9].
Based on the principle of multi-point and multi-segment sampling, CD mucosal biopsy is the most main diagnostic basis of CD. Its pathologic findings are typically non-caseous granulomas that are more easily detected on biopsy in about 30% of cases and are more common in smaller ulcers. In addition, common pathological features include segmental lesions, the presence of inflammatory cell infiltration in the inherent membrane, and submucosal broadening, marked fibrosis, whole-wall inflammation, fissured ulcers, and whole-layer lymphatic follicles in the intestinal wall [10, 11].
Imaging also plays a very important role in the diagnosis of CD. CT small intestine imaging or magnetic resonance enterography is the first choice for imaging examination, which is mainly used to evaluate inflammatory lesions in the small intestine. Magnetic resonance enterography is expensive but has the advantage of avoiding radiation and using no iodized contrast agents. The use of contrast-enhanced ultrasound can effectively improve the detection sensitivity of color Doppler ultrasound, which is outstanding in the diagnosis of the combined sensitivity and specificity of CD activity [12]. The sensitivity of small intestinal barium contrast is low and only suitable for dynamic observation in patients with intestinal cavity stenosis, and for the primary medical unit cannot conduct CT small intestinal imaging examination. Barium enema is not used much at present and has been replaced by colonoscopy.
The blood counts are used to monitor anemia in CD patients. The concentration of calcium protective protein in feces was associated with neutrophil infiltration in the intestinal mucosa, it has a strong sensitivity and specificity for CD diagnosis. As an inflammation marker, C-reactive protein and other inflammatory markers are used simultaneously to monitor disease activity to assess disease activity.
Although there is no corresponding name of CD in ancient Chinese medical books, there are abundant discussions about it, so the TCM diagnosis of CD was mainly based on symptom diagnosis. According to the main symptoms, CD is diagnosed as abdominal pain, diarrhea, bowel carbuncle, hemafecia, anal fistula, spouting bleeding from anus and other diseases [13, 14].
CD is associated with a number of pathogenic factors, either alone or in combination. Exogenous pathogenic factors, improper diet, emotional disorders, chronic physical deficiency were the main causes [14]. Exogenous pathogenic factors, such as cold, dampness and heat invade the body, resulting in blood stasis and abdominal pain and diarrhea. Unclean food, or overeating, or eating greasy and cold food can cause damp-heat or cold-dampness accumulating in stomach and spleen, blockage of abdomen Qi, producing diarrhea, bowel carbuncle; Internal injury of emotions, such as moodiness and worry leads to stagnation of qi induce pain easily; Weakness, prolonged illness or excessive fatigue, resulting in weakness of the spleen and stomach, transport and transformation weak that induce abdominal pain and diarrhea. CD mainly occurs in the intestine. In the theory of TCM, CD is also closely related to the spleen, stomach, liver and kidney, and is mainly caused by lesions in middle-jiao and lower-jiao.
The basic pathogenesis of CD is a mixture of deficiency and excess, cold and heat [15]. The deficient root include the deficiency of natural endowments, the deficiency of spleen and kidney, or the prolonged illness and overwork; Damp-heat accumulation, qi stagnation, phlegm and dampness, blood stasis are all belong to excessive superficial. The basic pathogenesis of CD varies according to the main symptoms. If abdominal pain is the main manifestation, the basic pathogenesis is exogenous pathogenic factors of coldness, wetness, heat, it result in qi stagnation, blood stasis, viscera and qi adverse, pain [16]; If the main manifestation is diarrhea, the basic pathogenesis is spleen deficiency and overabundance of dampness [16, 17]; If the main manifestation is intestinal carbuncle, the pathogenesis includes accumulation of dampness and heat, blood stasis, and the accumulation of phlegm and blood stasis [14].
According to the Guidelines of Traditional Chinese Medicine Diagnosis and Treatment of Digestive Diseases compiled by the Committee of Spleen-stomach Diseases of The Chinese Association of TCM in 2006, the common TCM syndromes of CD include the syndrome of liver-stagnation and spleen-deficiency, the syndrome of deficiency and cold of spleen and stomach, the syndrome of yang deficiency of spleen and kidney, the syndrome of cold-dampness impairing spleen splenic function, the syndrome of qi stagnation and blood stasis syndrome, the syndrome of damp-heat accumulation [18, 19].
The main symptoms are anorexia, belching, right abdominal pain or periumbilical distension pain and diarrhea while during abdominal pain and relief of pain after diarrhea. Acute abdominal pain, loose stools, belching and eat less, tongue reddish, and pulsed strings. Its attacks or exacerbations are often caused by irritation or nervous tension. The principle of treatment is soothing the liver and strengthening the spleen. The main prescriptions are Chaihu Shugan powder and Shenlinbaizhu powder [20] including bupleurum,
The main symptoms are dull abdominal pain, prefer warm and pressing, prolonged diarrhea, bowel bloating and abdominal distension, vomiting of clear water, loss of appetite, sallow complexion, dizziness, cold limbs, fatigue, pale tongue, thin and white coating, and slow and sunken pulse. The principle of treatment is to warm stomach and strengthen spleen. The main prescription is Shenling Baizhu powder and Fuzi Lizhong pill [21], including fried semen coicis, fried atractylodes macrocephala koidz, poria cocos,
The main symptoms are dull abdominal pain, irregular pain attacks and stop, prefer warm and pressing, thin pus around the anus, dull anal pain, loose stool, or diarrhea at dawn, loss of appetite, fatigue, cold limbs, soreness of waist and polyuria, pale tongue, or fat tongue with teeth marks, white coating, sunken or or thin and weak pulse. The principle of treatment is warming kidney and strengthening spleen. The main prescription is Changyangan soup [22], including astragalus membranaceus, poria cocos,
The main symptoms are acute abdominal pain, loose stool or water stool, or dysentery with blood and pus, heavy head and body, pale tongue, white and greasy coating, soft and slow pulse. The principle of treatment is clearing damp and strengthening spleen. The main prescription is Weiling soup, including atractylodes rhizome, dried tangerine peel, magnolia officinalis, polyporus umbellatus, rhizoma alismatis, cortex cinnamomi, atractylodes macrocephala koidz, radix glycyrrhizae.
The main symptoms are immovable abdominal lumps, abdominal distension or pricking, loose or bloody stools, purplish or petechial tongue, string and thin and hesitant pulse. The principle of treatment is regulating qi and dispersing blood stasis. The main prescription is infradiaphragmatic stasis-expelling decoction, including peach kernel, safflower, radix rehmanniae, radix angelicae sinensis, red peony, fructus aurantii,
The main symptoms are abdominal pain refusing to press, brown and smelly stool, or diarrhea with blood and pus, distending pain and scorching hot anus, thirsty and drinking cold, few and yellow urine, red tongue, yellow greasy coating, string and slippery or slippery and rapid pulse. The treatment principle is clearing heat and expelling damp. The main prescription is Baitouweng soup, including pulsatilla, coptis chinensis, phellodendron, ash bark.
Chinese herbal medicine.
Name | Pharmacological effects |
---|---|
Bupleurum | Diaphoresis; prevent malaria |
enrich blood; immunity enhancement | |
Poria cocos | Calm; promote healthy digestion |
Chinese yam | Improve immune and digestive function |
White lablab bean | Antibacterial and antiviral |
Atractylodes macrocephala koidz | Adjust gastrointestinal motility; inhibit ulcer |
Fructus aurantii | Increases gastrointestinal motility and contractility rhythms |
Lotus seed | Immune regulation; improve digestive function |
Amomum | bacteriostatic action; peristalsis enhancement |
Coix seed | Eliminate edema; immune regulation |
Rhizoma cyperi | Relaxes intestinal smooth muscle; anti-inflammatory |
Pericarpium citri reticulatae | Promote secretion of digestive juices; relieve asthma |
Raidix paeoniae alba | Antibacterial activity; analgesic |
Platycodon grangdiflorum | Dilate blood vessels; antitussive expectorant |
Radix glycyrrhizae | Regulate immunity; inhibit ulcer; protect liver |
Fried hawthorn | Help digestion; stop diarrhea |
Malt | Help digestion; antifungal |
Pinellia ternate | Antitussive expectorant; inhibit ulcer |
Inula flower | Relieve asthma; antitussive expectorant |
Giant typhonium rhizome | Anti-inflammatory; sedation; expectorant |
Corydalis yanhusuo | Spasmolysis, analgesia; suppression of gastric ulcer |
Common bletilla pseudobulb | Hemostasis; protect gastric mucosa |
Dried ginger | Inhibit ulcer; dilate blood vessels |
Panax notoginseng powder | Promote blood clotting; dilate blood vessels |
Nutmeg | Antibacteria; anti-inflammatory |
Antibacteria; antitumor; antidiarrhea | |
Roasted ginger charcoal | Hemostasis; acesodyne |
Atractylodes | Adjust gastrointestinal motility; diuresis |
Astragalus membranaceus | Strengthen immune system; inhibit ulcer; improve substance metabolism |
Cooked monkshood | Cardiac; antishock; dilate blood vessels |
Fructus psoraleae | Antibacteria; improve immune system |
Epimedium | Improve immune system; delay the progression of renal failure |
Magnolia officinalis | Promote the secretion of digestive fluids; anti ulcer |
Polyporus umbellatus | Diuresis; enhance immunity |
Rhizoma alismatis | Diuresis; anti-inflammatory |
Cortex cinnamomi | Cardiotonic; anti ulcer; anti-inflammatory |
Peach kernel | Reduce vascular resistance and improve hemodynamics; relax bowels |
Safflower | Dilate blood vessels; excited uterus; anticoagulation |
Radix rehmanniae | Hemostasis; antibiosis; immuno-enhancement |
Radix angelicae | Anti-microbico; Antipyretic analgesic |
Sinensis | Promote hematopoietic function; immunity enhancement |
Red peony | Antithrombus; reduce blood lipid; liver protection |
Radix scrophulariae | Antibiosis; dilate coronary arteries |
Pulsatilla | Anti-microbico; anti-inflammatory; immunity enhancement |
Coptis chinensis | Resistance of pathogens; Antipyretic; antineoplastic |
Phellodendron | anti-microbico; excite gastrointestinal smooth muscle |
Ash bark | Anti-inflammatory; analgesic; diuresis |
A large number of studies and clinical evidence show that TCM has obvious curative effect and function in the treatment of CD. The following is a brief summary of commonly used Chinese patent medicines.
It has the effect of harmonizing liver and spleen, astringent intestine to relieve pain [23] and commonly used in patients with disharmony of liver and spleen, diarrhea and abdominal pain, and nonspecific ulcerative colitis.
It has the effect of activating blood circulation and removing blood stasis, improving microcirculation. The cure rate can be improved by improving the high coagulation state of CD patients [24].
It has the effect of strenthening spleen and tonifying kidney. It can improve the humoral immunity of patients also used todiseases caused by the deficiency of spleen and kidney.
It has the effect of dispelling wind and detoxifying, dehumidifying and detumescence, relaxing tendons and dredging collaterals. Studies have shown that it can effectively improve the clinical symptoms of CD patient [25], but its toxicity of liver and kidney should be valued.
It has the effect of warming kidney and dispelling cold, astringent intestine and relieving diarrhea and commonly used for diarrhea caused by deficiency of kidney yang, the symptoms are borborygmus, intestinal distension, diarrhea at dawn, anorexia and indigestion, continuous diarrhea, yellowish complexion and cold limbs.
It has the effect of smoothing liver and regulating intestine, clearing the upper Jiao and warming lower Jiao and used for patient with chronic dysentery, the symptoms are abdominal pain, dysentery, vertex headache, attack intermittently, irritation and vomiting, extremities cold.
It has the effect of invigorating spleen and kidney, warming stomach and relieving pain, astringent intestine and relieving diarrhea, and used for patient with diarrhea of deficiency of spleen and kidney Yang, the symptoms are irregular stool, diarrhea at dawn with mucus, abdominal distention and pain, epigastric discomfort, and distention of lower abdominal.
It has the effect of invigorating and benefiting spleen qi and lifting collapsed qi, be used for diarrhea caused by weakness of spleen and stomach and collapse of middle qi.
It has the effect of invigorating spleen and warming kidney, astringing intestine to relieve diarrhea, and be used for chronic diarrhea caused by spleen deficiency or Yang deficiency of spleen-kidney, the symptoms are chronic abdominal pain and diarrhea, loose stools, anorexia and abdominal distension, weak waist, fatigue and cold limbs.
It has the effect of clearing away heat and eliminating dampness, promoting qi circulation to relieve pain, and be used for dysentery caused by dampness-heat of large intestine, the symptoms are stool with pus and blood, tenesmus, fever and abdominal pain.
It has the effect of warming spleen dispersing cold, relieving diarrhea and pain, and can be used for cold syndrome of spleen and stomach, the symptoms are anorexia and abdominal distension, abdominal pain and nausea, weak pulse, cold limbs, or headache attacked by cold, and any chronic disease caused by cold.
It has the effect of nourishing Yin and blood, tonifying qi and strong intestine, removing blood stasis and generating muscles. The symptoms are dull abdominal pain, persistent diarrhea, stool with pus and blood, low fever in afternoon, dizziness, insomnia, night sweats, irritability, weight loss and fatigue, red tongue, thin and less coating, thin and rapid pulse.
Acupuncture therapy is widely applicable to mild and moderate CD patient with no age or gender restrictions, but not for patients with severe CD, in pregnancy and lactation, with mental disorders, with severe tumors, or patients with serious diseases of the heart, liver, kidney, brain and hematopoietic system [26], they need adopt appropriate western medicine to save lives and avoid critical situations.
The basic acupoint prescriptions for CD treatment include Tianshu (ST25), Zusanli (ST36), Shangjuxu (ST37), Guanyuan (RN4), Qihai (RN6), Zhongwan (RN12) [27]. Patients with syndrome of liver depression and spleen deficiency can add Taichong (LR3) and Pishu (BL20); Patients with syndrome of deficiency and cold of spleen and stomach can add Shangwan (RN13) and Xiawan (RN10); Patients with syndrome of yang deficiency of spleen and kidney were added with Mingmen (DU4), Pishu (BL20) and Shenshu (BL23); Patients with syndrome of cold dampness disturbing spleencan add Yanglingquan (GB34) and Fenglong (ST40); Patients with syndrome of qi stagnation and blood stasis can add Taichong (LR3) and Qihai (SP10); Patients with syndrome of dampness-heat accumulation can add Quchi (LI11) and Hegu (LI4). During the acupuncture treatment, the abdomen of CD patients is usually the main part, including the legs and back. The treatment is normally performed for about 20-30 minutes each time, once every other day. If the patient is in serious condition, the curative effect can be enhanced once a day.
Acupuncture therapy is mainly targeted at excess, heat syndrome and relatively simple symptom. For patients with syndrome of intermingled deficiency and excess, acupuncture therapy often combines with moxibustion therapy. The research of Wu Huangan research group showed [28, 29] that moxibustion can effectively improve the clinical symptoms and the quality of life of CD patient. The methods were mainly acupuncture at Tianshu (ST25), Zhongwan (RN12), Qihai (RN6). Mix the powder of aconite, cinnamon, salvia miltiorrhiza, safflower, costusroot, coptis chinensis and borneol; add yellow rice wine and mix it to form a thick paste; Make a medical cake in a mold and place it at the above acupoints, and place moxa cone on medical cake, moxibustion twice for each acupoint; Combined with acupuncture at Zusanli (ST36), Shangjuxu (ST37), Sanyinjiao (SP6) and Gongsun (SP4), the goal of synergetic treatment and enhanced curative effect was finally achieved.
In addition to TCM, Chinese patent medicine, acupuncture and moxibustion treatment methods, there are other unique therapies, and the effect is also very effective. Through clinical controlled experiments, Songnian proved [30] that auricular application can effectively alleviate the abdominal pain of CD patients. Enema administration combined with internal medicine can greatly improve the curative effect of CD [31]. Hu Zhengchao and et al. [32] have found that Chinese medicine fumigation, external washing and sitz bath could effectively alleviate the symptoms of anal fistula patients with CD, not only improving local blood circulation, but promoting the healing of anal fistula canal. In addition, fecal flora transplantation is also a new treatment method for CD combined with Chinese medicine, it works by transplanting fecal material from a healthy donor into the patient’s gut to restore the intestinal flora diversity and thus achieve a good therapeutic effect [33].
CDAI can be used to evaluate the disease activity and the efficacy of CD, including five aspects of the patient’s general condition, such as abdominal pain, diarrhea, abdominal mass and complications [34]. The higher the total score, the more serious the disease. A score of ≤4 indicates remission, a score of 5-8 indicates moderate activity, and a score of ≥9 indicates severe activity. It can be scored in three stages before, during and after treatment to dynamically observe the changes of the disease.
The total score of TCM syndromes was used to evaluate the clinical symptoms of abdominal pain, diarrhea, pus and blood stool, tenesmus, belching, nausea and vomiting and fever. The total scores before and after treatment was compared, if the total score decreased by ≥90% compared with that before treatment, it is judged as clinical remission. If the total score decreased by ≥70% and < 90%, it is judged as significant effect; if the total score decreased ≥30%and < 70%, it is judged to be valid; if the total score decreased <30%, it is judged to be invalid.
Simplified endoscopy score for CD (SESCD) can be used for diagnosis and efficacy evaluation of CD. The score items mainly include ulcer size, ulcer area, affected intestinal area, intestinal lumen stenosis and the condition of mucosal healing. The lower the score, the better the mucosal healing degree. A score ≤ 3 is remission, a score 4-10 is mild activity, a score 11-19 is moderate activity, and a score more than 20 is severe activity [35].
Inflammatory bowel disease quality of life questionnaire (IBDQ) was used for CD evaluation, including intestinal symptoms, systemic symptoms, emotional ability and social ability. Scores were recorded for both the pre-treatment and post-treatment stages, with higher scores indicating better quality of life.
Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate the severity of the anxiety and the depressive symptoms of CD patients. Scores were performed according to the symptoms, and the patients were divided into mild, moderate and severe by 50 score. Scores were recorded before and after treatment. Scores below 50 after treatment indicated efficacy.
The development of CD is a long-term and progressive process. The clinical efficacy evaluation should combine the short-term with long-term efficacy. In addition to the general clinical symptoms, it is also important to observe the status with the ulcer of intestinal mucosa and actively prevent perianal lesions it should also focus on the observation of intestinal mucosal ulcer and the active prevention of perianal lesions of CD patients.
Improper diet is one of the major causes of CD. In TCM, dampness, heat and cold pathogens easily invade the body through improper diet, damage spleen and stomach, and accumulate in intestines. Therefore, CD patients should pay attention to their daily diet, light and easy digestible food is better, avoid eat irritating food, try not to eat or eat less fat and greasy food, or raw and cold food.
CD is a chronic disease in the developing course of disease, patients are prone to anxiety or depression that aggravating the symptoms of body and mind. Therefore, in the process of diagnosis and treatment, attention should be paid to the psychological and emotional intervention of the patients to avoid negative emotional stimuli, relieve their anxiety or depression situation, guide the correct understanding of disease with good positive attitude [36, 37].
CD is persistent and prone to relapse, so it is important to adjust lifestyle, control risk factors and change improper habits. Smoking is an important factor for CD patient, which often aggravates the disease and more likely to cause complications. For CD patients, the first step is to quit smoking, adjust lifestyle, and eliminate risk factors. In addition, patients should have regular daily life, reasonable work and rest, moderate diet, maintain the spleen and stomach, do proper exercise, avoid fatigue, adjust emotions, comply with four seasons, and maintain healthy energy [38].
The development of CD is a long-term process, attention should always be paid to physical changes through outpatient, inpatient follow-up, telephone follow-up, and regular review, to understand the recurrence of disease, cancer prevention.
The cause of CD is still unclear, it is mainly related to improper diet, disorder emotion, attack of external evil, internal deficiency in TCM theory. The main pathogenesis is deficiency of spleen and kidney combined with damp-heat accumulation, qi stagnation, phlegm and dampness and blood stasis. The holistic concept and syndrome differentiation are the general principles of TCM treatment, the diagnostic criteria of CD are generally accorded to the consensus Opinions on the Diagnosis and Treatment of Inflammatory Bowel Disease as the reference, and comprehensive judgments are mainly made based on the clinical symptoms, endoscopy results, imaging examinations and pathological tissues of the patients. For example, the concentration of fecal calprotectin was positively correlated with CDAI score, SEC-CD score, CD clinical activity and mucosal healing, it could objectively reflect the inflammatory activity of CD [39]. Imaging diagnostic techniques, magnetic resonance imaging (MRI) and computerized tomography (CT), can be used to assess the activity of CD by showing changes in the thickness of the intestinal wall, abnormal intensification of the intestinal wall, intestinal segment stenosis, abnormal increase in mesenteric vessels, enlarged lymph nodes, fistulas, ulcers, and abscesses [40]. According to the symptoms and characteristics of different syndroms of CD, corresponding treatment methods were adopted, among which Chinese herbal medicine and acupuncture and moxibustion treatment were the most common and had significant curative effects.
With the development of TCM treatment of CD in recent years, certain progress and achievements have been made in clinical and experimental research, such as the gray matter structure of CD patients had significant changes, which was correlated with anxiety and depression status and course of disease [41]. In resting-state, the brain abnormal activities in insula and MCC of CD patients are different between remissive CD patients with and without abdominal pain, and are closely related to the severity of abdominal pain [42], aberrant functional connectivity of the amygdala may be involved in processing of visceral pain and sensation, and emotion in CD [43]. Herb-partition moxibustion combined with acupuncture can improve the clinical common symptoms of abdominal pain, diarrhea, fatigue and anorexia for mild and moderate CD [26]. Both treatments of electro-acupuncture and moxibustion improved cortex-subcortical coupling in remissive CD patients, but electro-acupuncture regulated homeostatic afferent processing network, while moxibustion mainly regulated the default mode network [44]. In CD rats, moxibustion can up-regulate the A20 expression level and down-regulate the expression of TNFR1, TRADD, and RIP1, and increase cell apoptosis in the intestinal epithelial barrier [45]. It is important to relieve the damage of intestinal mucosal barrier and maintain its functional integrity for patients [46]. Many experimental studies have shown that moxibustion can significantly down-regulate the expression of NF - κB P65, TNF-α and IL-1 in the colon tissue of CD model rats [47] and down-regulate the proteins expression of MCP-1 and IL-8 to reduce the expression of downstream inflammatory factors, relieve intestinal inflammation, and improve the morphological structure of colon tissue [48].
However, the pathogenesis of CD is still unclear, there is a lack of prospective studies even large sample and multicenter clinical trials, which still need to be further studied and explored.
Authors thank the Inflammatory Bowel Disease Group of Gastroenterology Branch of Chinese Medical Association for the Consensus opinions of TCM diagnosis and treatment experts on Crohn’s disease.
Authors thank for the support of National Basic Research Programme of China (973 programme, grant number 2015CB554501).
There is no conflict of interest among authors.
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Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5377,totalCrossrefCites:24,totalDimensionsCites:58,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"71103",title:"Preparation of Nanoparticles",slug:"preparation-of-nanoparticles",totalDownloads:3140,totalCrossrefCites:11,totalDimensionsCites:25,abstract:"Innovative developments of science and engineering have progressed very fast toward the synthesis of nanomaterials to achieve unique properties that are not the same as the properties of the bulk materials. The particle reveals interesting properties at the dimension below 100 nm, mostly from two physical effects. The two physical effects are the quantization of electronic states apparent leading to very sensitive size-dependent effects such as optical and magnetic properties and the high surface-to-volume ratio modifies the thermal, mechanical, and chemical properties of materials. The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:72,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:78,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:125,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"22",title:"Business, Management and Economics",doi:"10.5772/intechopen.100359",issn:"2753-894X",scope:"\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. 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",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. He has published more than 400 works in his academic career and visited twenty-two universities worldwide as a visiting professor. Dr. Bobek is a member of the editorial boards of six international journals and a member of the Strategic Council of the Minister of Foreign Affairs of the Republic of Slovenia. He has a long history in academia, consulting, and entrepreneurship. His own consulting firm, Palemid, has managed twenty significant projects, such as Cooperation Program Interreg V-A (Slovenia-Austria) and Capacity Building for the Serbian Chamber of Enforcement Agents. He has also participated in many international projects in Italy, Germany, Great Britain, the United States, Spain, Turkey, France, Romania, Croatia, Montenegro, Malaysia, and China. Dr. Bobek is also a co-founder of the Academy of Regional Management in Slovenia.",institutionString:"Universities of Applied Sciences FH Joanneum, Austria",institution:null},editorTwo:{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",slug:"tatjana-horvat",fullName:"Tatjana Horvat",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hXb0hQAC/Profile_Picture_1642419002203",biography:"Tatjana Horvat works as a professor for accountant and auditing at the University of Primorska, Slovenia. She is a Certified State Internal Auditor (licensed by Ministry of Finance RS) and Certified Internal Auditor for Business Sector and Certified accountant (licensed by Slovenian Institute of Auditors). At the Ministry of Justice of Slovenia, she is a member of examination boards for court expert candidates and judicial appraisers in the following areas: economy/finance, valuation of companies, banking, and forensic investigation of economic operations/accounting. At the leading business newspaper Finance in Slovenia (Swedish ownership), she is the editor and head of the area for business, finance, tax-related articles, and educational programs.",institutionString:null,institution:{name:"University of Primorska",institutionURL:null,country:{name:"Slovenia"}}},editorThree:null},{id:"87",title:"Economics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/87.jpg",isOpenForSubmission:!0,editor:{id:"327730",title:"Prof.",name:"Jaime",middleName:null,surname:"Ortiz",slug:"jaime-ortiz",fullName:"Jaime Ortiz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002zaOKZQA2/Profile_Picture_1642145584421",biography:"Dr. Jaime Ortiz holds degrees from Chile, the Netherlands, and the United States. He has held tenured faculty, distinguished professorship, and executive leadership appointments in several universities around the world. 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The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11423,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. 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It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:287,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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