Incidence rates of abnormal findings.
\r\n\tApplied and basic studies - Field studies and lab assays of fungicides can be discussed. We also look for examples of application methods, which may include timing of application, tools for application, fungicide compatibility, phytotoxicity, etc. Field trials have to have at least two years of data;
\r\n\tAdaptation of Integrated Plant Disease Management - How the IPM practice has been adapted in the field. Application of disease risk models, or use of fungicide application aids, which can be hardware or software. The introduction of a new tool for growers can also be included;
\r\n\tNovel fungicides - In addition to the traditional chemical approach, alternative materials (enzymes, oils, extracts, etc.), biological control agents, or plant defense activators can be discussed;
\r\n\tAdaptation of new technologies - Examples will be the use of unmanned vehicles, sensor technologies, advanced sprayers, or disease forecast systems for precision agriculture;
\r\n\tFungicide resistance - Unfortunately, we cannot ignore the fact that fungicide-resistant strains are widespread. Documentation of fungicide-resistant strains, the introduction of new technologies and methods can be discussed.
Recent studies have reported various changes in the feet of infants and school-age children [1, 2]. Notable changes include hallux valgus, bunionette [1, 2], floating toes, and undeveloped foot arch [3]. However, fact-finding surveys on different age groups have been lacking, whereas surveys on small populations in limited areas have been reported. Therefore, surveys to determine changes and their prevalence among children over time are required.
Much has remained unknown about the cause of these changes in foot morphology. Measures recommended for the proper development of the feet include playing outdoors [4], exercising with bare feet [5], and wearing shoes properly [2, 6]; however, these measures lack evidence. Therefore, elucidating the causes of such morphological changes and proposing specific measures for prevention and correction have become necessary.
To tackle these issues, Kinjo University in Japan has established the
To survey foot-ground contact and toe deformities and share findings with children, guardians, and educators;
To increase children’s knowledge about and interest in their feet and provide them with useful knowledge, such as how to choose the right shoes, the proper way of wearing shoes, and how to acquire good exercise habits;
To accumulate data and present scientific evidence useful for education;
To widely disseminate trends and measures based on survey results to the community and academic societies; and
To provide education on foot maintenance, how to select shoes, and how to wear shoes.
To date, this project has conducted fact-finding and annual surveys on approximately 3000 children. The subsequent text summarizes the findings from these surveys and discusses common changes in foot morphology among children and possible measures for prevention and relief.
This project has been conducting fact-finding surveys on feet and shoes in infants and school-age children since 2014. Table 1 presents the incidence rates of abnormal findings among children aged 3–8-years. Hallux valgus (first metatarsophalangeal angle ≥ 16°) tended to increase from 6 years of age, whereas bunionette (digitus quintus angle ≥ 12°) was found to be highly prevalent among 3-, 6-, and 8-year-old children (approximately 40%, 50%, and 75%, respectively). Moreover, foot arches were not formed in approximately 40% of 8-year-old children (third grade in elementary school). Floating toes (i.e., toes are not in contact with the ground when standing) were common among children from an early age, where children with 10 toes touching the ground were fewer than those who did not [7]. A cross-sectional survey [8] on elementary school, middle school, and high school students has demonstrated that the digitus quintus angle in high school students was greater than that in elementary school students. Moreover, the prevalence of floating toes increased with age by 68.1%, 75.0%, and 78.1% in elementary school, middle school, and high school students, respectively (Table 2). These fact-finding surveys have revealed that children today exhibited high prevalence rates of bunionette, undeveloped foot arch, and floating toes, which supported the findings from previous studies [9, 10].
3 y/o | 4 y/o | 5 y/o | 6 y/o | 7 y/o | 8 y/o | ||
---|---|---|---|---|---|---|---|
(n = 566) | (n = 545) | (n = 560) | (n = 274) | (n = 266) | (n = 150) | ||
Hallux valgus | (%) | 6.6 | 6.2 | 4.2 | 13.4 | 25.1 | 24.0 |
Bunionette | (%) | 39.6 | 38.8 | 39.1 | 52.1 | 68.1 | 74.7 |
Undeveloped foot arch | (%) | 50.6 | 49.2 | 37.0 | 42.1 | 39.2 | 39.3 |
Floating toes | (%) | 65.4 | 63.6 | 63.3 | 68.8 | 76.7 | 79.3 |
Incidence rates of abnormal findings.
Elementary school students (n = 119) | Middle school students (n = 44) | High school students (n = 160) | ||
---|---|---|---|---|
Hallux valgus angle | (°) | 10.5 ± 5.4 | 12.0 ± 4.7 | 10.8 ± 5.1 |
Digitus quintus angle | (°) | 13.6 ± 4.9 | 14.7 ± 4.7 | 15.2 ± 5.0* |
Floating toes | (%) | 68.1 | 75.0 | 78.1 |
Toes angles and floating toes in students.
Tukey-Kramer test; vs. elementary school students, p < 0.05.
Furthermore, a survey on the difference in size between feet and shoes was conducted on infants, elementary school students, middle school students, and high school students. Table 3 summarizes the results. Japan Engineering Standards stipulated that shoe size indicates the foot length that can fit in the shoe; therefore, appropriate shoe size should be equal to the foot length. A survey on measured foot lengths and shoe sizes revealed that 48.0% and 23.5% of infants and elementary school students, respectively, and 10% of middle school and high school students were wearing right-size shoes, whereas older children tended to wear shoes larger than the right ones [7, 8]. When guardians, middle school students, and high school students were asked about the reason for purchasing particular shoe sizes, their most common responses were: “did not know what the right size was,” “intentionally selected a larger size given the further growth of the feet,” and “thought the purchased one was the right size.”
Infants | Elementary school students | Middle school students | High school students | ||
---|---|---|---|---|---|
(n = 952) | (n = 119) | (n = 44) | (n = 160) | ||
Undersized shoes | (%) | 5.2 | 2.5 | 0 | 0 |
Right size | (%) | 48.0 | 23.5 | 2.3 | 7.5 |
Oversized shoes | (%) | 46.9 | 73.9 | 97.7 | 92.5 |
Size difference between feet and shoes.
These results indicated that people tended to purchase oversized shoes due to a misunderstanding of the right shoe size; the assumption that loose-fitting shoes are the right size; or an overestimation of the growth speed of children’s feet. In Japan, no opportunities practically exist to measure the size of feet, such that many people are unaware of the size of their feet. Thus, people must rely on how the shoes feel when putting on shoes or have children put on their shoes to determine the appropriate size. Moreover, opportunities to learn about shoes in Japan are lacking, and the Japanese shoes culture prefers shoes that are easy to wear and remove [11, 12]. These examples are a few of the reasons why children and their guardians fail to select appropriate shoe sizes.
Changes caused by wearing inappropriate shoe size constantly include hallux valgus, bunionette, and keratonosis of the skin, such as calluses [13, 14]. Especially, many studies reported a correlation between keratonosis and pain [15]. Interestingly, several studies observed that complaints about pain are more common in people wearing oversized shoes than in those wearing undersized shoes [16].
In terms of morphological changes related to the toes, bunionette and floating toes were frequently observed in individuals wearing inappropriate-size (oversized) shoes than in those wearing appropriate-size shoes (Table 4) [17]. Thus, the constant use of oversized shoes is likely to promote toe deformities and injuries in addition to other risks of wearing shoes [18, 19].
Right size | Inappropriate-size | p value | ||
---|---|---|---|---|
(n = 308) | (n = 321) | |||
Percentage | (%) | 49.0 | 51.0 | — |
Hallux valgus | (%) | 6.7 | 4.7 | 0.14 |
Bunionette | (%) | 33.5 | 38.2 | <0.05 |
Undeveloped foot arch | (%) | 44.5 | 48.6 | 0.16 |
Floating toes | (%) | 52.6 | 74.5 | <0.05 |
Changes in foot morphology by shoe size.
Chi-square test.
This project conducted a one-year follow-up study to examine whether the use of appropriate-size shoes alleviated the changes in foot morphology [20, 21]. We provided 120 students (n = 35, 17, 17, 25, and 26 in 1st, 7th, 8th, 10th, and 11th grades, respectively) with shoes fitted to their foot lengths and widths. The students were requested to wear them as indoor shoes in their schools for 1 year. The result indicated significant increases in the arch-height ratio (the height from the floor to the navicular bone/foot length) and significant decreases in the number of floating toes (Table 5). These findings suggested that using right-size shoes facilitates foot arch development, improves floating toes, and helps toes to fulfill their original function.
Elementary school students (n = 35) | Middle school students (n = 34) | High school students (n = 51) | |||||
---|---|---|---|---|---|---|---|
First time | After 1 year | First time | After 1 year | First time | After 1 year | ||
Arch–height ratio | (%) | 9.6 ± 5.2 | 13.6 ± 8.0 | 12.4 ± 3.5 | 13.7 ± 3.1 | 11.8 ± 2.7 | 12.6 ± 3.4a |
Percentage of floating toes | (%) | 77.1 | 68.6 | 70.6 | 55.9 | 84.3 | 52.9 |
Total number of floating toes | (Number) | 92 | 67b | 71 | 34b | 103 | 41b |
Changes in arch–height ratio and floating toe at 1 year follow-up.
Chi-square test; p < 0.01.
Paired t-test; vs. first time, p < 0.05.
In Europe, people are accustomed to selecting the right-size shoes and wearing them properly to protect foot health [12]. As previously described, no such custom exists in Japan, such that selecting appropriate shoes is difficult for many Japanese people due to the lack of awareness about their foot size.
This project conducted a two-year longitudinal study on five-year-old children to examine the educational effects of providing knowledge on feet and shoes, how to select right-size shoes, and how to wear them properly [22]. However, the study observed no notable differences in the fitness of shoe size and changes in foot morphology. The results suggested that education should be initiated as soon as children are beginning to wear shoes. Moreover, education on how to wear shoes, instead of the size of shoes and whether shoes have any strap, was more influential among pre-school children. Thus, future studies should continue the education on the proper selection and wearing of shoes. Furthermore, an assessment of educational effects should be conducted.
In this project, we surveyed the common changes in the foot morphology of children and shared the trends observed from the results. We also presented possible measures to community residents. We plan to continue surveys and hope to characterize the effects of selecting appropriate shoes and wearing shoes properly on foot development. In addition, the fact remains that various foot changes are occurring in children today as demonstrated by previous studies and the surveys in this project. Despite these individual differences, we hope to build scientific evidence useful for education toward the healthy development of children’s feet.
The authors received 213 pairs of educational shoes from the Japan Education Shoes in 2017 and 2018. There is no conflict of interest to be disclosed for other studies.
This work was supported by JSPS KAKENHI Grant Number JP19K20087.
Pesticides are the integral and significant part of modern agriculture. Pesticide usage is incredibly valuable for increasing food production in fulfilling the demand of over-rising population. It has been previously stated by Webster et al. [1] that without pesticide use considerable economic losses will occur. The application rate of agricultural pesticides has swiftly augmented in different developing and developed countries [2]. Therefore, pesticides help in significant increase of yield and prevent the crop losses due to pest and pathogen attack. Application in a smaller quantity gives positive results but large quantity causes negative effect on environment, human health, and other beneficial organisms such as insects responsible for pollination [3]. However, non-judicious use causes various detrimental effects on environment and damages the ecosystem including economic loss of the farmers.
In formulated forms, pesticides are effective in very small quantity. There are many conventional pesticide formulations available in the market, which are being marketed and used in Asian countries in the form of dustable powder (DP), wettable powder (WP), emulsifiable concentrate (EC), soluble liquids (SL), etc. These conventional formulations are effective but due to certain limitations such as toxicity, cost, pest resistance, environmental contamination, death of beneficial organisms (e.g., honey bee), and human health problems they attracted interests toward advanced and safer pesticide formulation techniques [4]. Interestingly, in past 1990s, Asian countries explored certain new-generation formulation, which were solvent free, long lasting, safe and caused no effect on non-target organisms [5, 6].
With the advancement of new formulation technologies in Asian countries, many new-generation formulations have been developed to maintain a special place in international markets. In Asian countries, government supports the pesticide supply for the enhanced food production but its overuse (conventional formulations) has resulted in pesticide residue problem causing non-target and ecosystem toxicity.
In order to improve the safety of the user and ecosystem from the hazardous pesticides, Institute of Pesticide Formulation Technology (IPFT), India, has been engaged in developing new-generation formulations of synthetic as well as botanical pesticides. This chapter summarizes all the formulation advancement developed by IPFT for the safe and smart delivery of pesticide and reduces the adverse effects associated with conventional formulations.
A pesticide is the main active ingredient (actual chemical that controls pest population), which may be of synthetic chemical or botanical origin. Various chemical- and botanical-based pesticides have different physical and chemical characteristics such as solubility, viscosity, and physical state. Moreover, different pesticides act differently for various types of pest populations; for instance, some are effective for crawling insects, while the others are for flying insects. If a farmer uses active ingredient in pure form, he will face assured difficulties as follows:-
Active pesticide in unformulated form cannot spread evenly.
In pure form, pesticides show phytotoxicity and toxicity toward non-targets. Pesticide in unformulated form environment-related hazards will enhance.
After formulation development, application process is easy and convenient.
To resolve all these issues, formulation scientists formulate the active ingredient into different forms. As per the Knowles, “A pesticide formulation is a mixture of active ingredient with different inert materials to improve its stability during storage, easy handling, improves safety, application, or effectiveness towards pest population” [5].
In Asia and Pacific regions, the most common formulations being used are dustable powders, emulsifiable concentrates, wettable powders, granules, soluble liquids, etc., for the control of insect pest and many pathogenic diseases [7, 8]. The most common conventional formulations are discussed below:
Schematic illustration showing key steps involved in dust formulation and its mode of application.
Schematic representation showing key steps involved in granular formulation and its application.
Diagrammatical representation showing steps involved in WP formulation and its application.
Schematic representation showing key steps involved in soluble powder formulation and its application.
Schematic representation showing key steps involved in EC formulation and its application.
The main limitation is linked with the organic solvents that are mainly petroleum solvents being used in Asian countries. These petroleum solvents make the formulation flammable and cause dermal toxicity to the user. To rectify the problem associated with these conventional formulations, new formulations have been developed, which are improved and advance in terms of user and environment safety.
The major objectives of IPFT (India) to develop new formulation technologies are as follows:
To make the formulation techniques of different pesticide easy and convenient application.
To make pesticide formulations labor saving.
To prepare safer formulations for user and environment.
To reduce the toxicity of pesticides toward non-targets.
To minimize environmental contamination.
To enhance bio-efficacy against different types of pests.
To make the formulation economical and lower the frequency of applications.
More advanced form of WDG is water-soluble bag-sealed WDG. In these packing bags, WDG are in partially disintegrated form, which can easily disintegrate in spray tanks (Figure 6).
Schematic representation showing key steps involved WDG formulation and its application.
Basic composition of WDG contains 50 to 90% pesticide (active ingredient) along with dispersing agents and wetting agents [10]. A dispersing agent is a type of surfactant that is added to formulations to improve the separation of the particles and inhibit particle size growth, and their settling or clumping. Pang et al. [11] reported lignosulfates as effective dispersing agent in water-dispersible granular formulations due to a high degree of sulfonation, high intrinsic viscosity property, and high molecular weights. Recently, sodium salt of methacrylic acid/styrene/sodium p-styrene sulfonate copolymer (SMSS) has synthesized a novel dispersant by free radical polymerization mechanism. This new dispersant has strong resistance to hard water and showed high performance and show above 90% suspensibility in hard water [12].
IPFT has developed water-dispersible granules of liquid pesticide such as triazophos. Recently, IPFT developed neem WDG for mosquito control. Other WG formulations that have been developed by IPFT for agricultural usage are Captan 83WG, Isoproturon 75WG, Metamitron 70 WG, Mancozeb 75WG, Chlorothalonil 75WG, Endosulfan 75WG, Carbendazim 86WG, Divrinol 50WG, Thiram 80WG, Cypermethrin 40 WG, Thiamethoxam 25 WG, Deltamethrin 25 WG, and Triazophos 20 WG.
Schematic key steps involved suspension concentrate formulation and its application.
The main advantages of suspension concentrates are easy application, no organic solvent used, and free from any toxicity to users and environment.
Careful selection of surfactant system is necessary to prevent hetero-flocculation (agglomeration of solid particles and droplets) during storage. There are three types of instabilities identified in SC during storage due to particle size change and they are particle aggregation, Ostwald ripening, and particle sedimentation [14].
Effect of polymeric surfactant on physical stability has investigated in suspension concentrate. Polymeric surfactants provide high critical micellar concentration (CMC) and reduced Gibbs-free energy ΔG [15]. In another study, silicone surfactant is used as adjuvants in the SC formulation that results in high performance of surfactant and improves the physical stability and the quality of the formulation [16].
Particle size is also an important factor for stability as well as bio-efficacy enhancement. In a study, Vineela et al. [17] have reported that in
Some pesticides are photosensitive and easily decomposed. In a study, an amine-modified ligno-sulfonate surfactant was synthesized to make the SC formulation anti-photolysis [18]. Similar advancements have been conducted in IPFT on botanical-based formulations to inhibit photolysis. In addition to this, IPFT has developed several other UV protectant-based SC formulations for various SC formulations.
Entomopathogenic fungus,
Along with this IPFT has developed many synthetic and botanical pesticide SC formulations for agricultural pest control which include Isoproturon 50SC, Carbendazim 50SC, Sulfur 52SC, fipronil 5SC, thiomethxam 14.1% + Lamda cyhalothrin 10.6% SC, metamitron 70 SC, Neem SC, etc.
Capsule suspension (CS) is water-based slow release formulation containing active ingredient encapsulated inside microcapsules up to 10 microns size (Figure 8). CS formulation is a stable suspension of micro-capsules containing active ingredients and these microcapsules are synthesized by interfacial polymerization mechanism. CS formulations provide regulated, slow, and delayed the release of pesticides. This formulation is safer delivery mode by giving protection from toxic ingredients and stops the pesticide rate of degradation.
Schematic representation of capsulated suspension formulation procedure a. and its application b.
CS are water-based (free from any organic solvent) homogeneous and uniform suspension formulation. Its application is safe, and provides enhanced and efficient bio-safety with reduced phytotoxicity. In order to develop CS formulation, the active ingredients should have low solubility in water and altogether hydrolytically stable. The pesticide from microcapsules gets slowly released after application. The CS formulations are slow release formulations and theses formulations prolong the availability of pesticide at target site. The CS formulation reduces environmental contamination and leaching of pesticide and degradation of active ingredient by environmental factors like sunlight.
In a recent study, it was found that carboxy, methyl cellulose (CMC) and diallyl, dimethyl, ammonium chloride (DMDAAC) as monomers are the effective encapsulating agents of avermectin pesticide. This capsulated form gave higher performance and has excellent UV protecting property [20]. Thus, IPFT has developed CS for seed dressing for targeted delivery of pesticides without any wastage in environment [21].
Cyhalothrin is the most effective and broad-spectrum pesticide used in Central Asia. It has dual mode of action contact as well as systemic. Most efficient CS formulations developed by IPFT for sustainable agricultural applications are Lambda Cyhalothrion 10CS and Lambda Cyhalothrin 4.9CS.
Microemulsion (ME) is the most efficient delivery system of botanicals as well as synthetic pesticides. By definition- “ME is a system of water, oil, and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution” [22]. Droplet size of ME is in nano-range, that is, 10 nm–20 nm. Based on dispersion medium, ME can be classified into two categories: O/W ME and W/O ME. Aqueous dilution of ME is required before spray application (Figure 8). Being a new-generation formulations, the characteristic features of MEs are nano sized, thermodynamically stable system with good penetrability, quick spreading ability, low and zero interfacial tension, and extended shelf life formulation.
In phase dispersion method, dispersed phase is surfactant system along with active ingredient and water is the dispersant. The whole phase of inversion occurs in controlled temperature and other conditions for active kinetics (Figure 9).
Diagrammatic representation of the phase inversion method of microemulsion.
Cyhalothrin ME was developed and found as the most promising pesticide formulation in China [23]. Carbendazim is another pesticide that was formulated as ME and its bio-efficacy was evaluated in
Along with the synthetic pesticides, botanical-based microemulsions are well known in Asian agriculture. Essential oil in microemulsion form gives superior bioactivity as compared with emulsion forms [26]. In microemulsion system, spreading capacity and dispersion improves over applied plant surface. Therefore, microemulsion system is the important vehicle for essential oil targeted delivery in a small quality without any losses [27, 28]. In addition, essential oil bio-constituents uniformly disperse after application over active targeted sites and offers improved bio-efficacy [29].
Clove (CO) and lemongrass oil (LGO) ME have investigated as efficient antifungal agents against
IPFT has developed different types of microemulsions of synthetic pesticides along with botanical pesticides. In addition to this, IPFT has prepared microemulsion system with inbuilt adjuvants and synergist, which will enhance the formulation efficiency and efficacy. There are different botanical-based microemulsions have been developed and formulation techniques transferred to various agrochemical industries.
Nanoemulsions are defined as nano-sized droplets dispersion in immiscible liquids (Figure 10). Different pesticides have been formulated as nano-formulation and researchers have quantitatively estimated the pesticide content by various characterization techniques [31]. This formulation exhibits the property of encapsulation and regulated release of pesticides for extended period of time as in controlled release formulations.
Diagrammatic representation of nano-formulation preparation and its application.
Characteristic features of nanoemulsion formulation techniques are small droplet size with low amount of surfactant and active ingredient. Similar to ME, NE can enhance solubility of active ingredient, increase bioactivity, and improve spreadability (during application). Moreover, it can reduce volatility and hydrolysis of active ingredient.
It has been evaluated that nanoemulsion formulation showed enhanced bio-efficacy results compared with emulsifiable concentrates (EC) and microemulsions (ME). This study was conducted in third-instar larva of
Many botanical-based nanoemulsions have been developed in recent years. In a study,
In addition to this, nanoemulsion formulation also been used as edible coating to improve the storability of fruits and vegetables in postharvest conditions for enhancing shelf life and prevention of microbial growth over fruits and vegetables [38].
IPFT has also contributed in developing many nanoemulsions of synthetic as well as bioactive pesticides and different essential oils for controlling various agriculture pests and micro-organisms. Besides this, IPFT has prepared nanoemulsion with botanical synergists and adjuvants to enhance the bioactivity and stability of nanoemulsion formulations. Moreover, combination of nanoemulsions is further developed for the amplified pest control applications in intense pest attacking conditions.
Emulsion in water (EW) formulation is suitable for liquid or a liquid or oily active ingredient. These formulations are dispersion of active ingredient in aqueous continuous phase (Figure 11). The size of the dispersed droplets ranges generally from 0.5 to 4–5 μm. EW formulations are obtained by high-shear emulsification process. Principally, EW formulations contain pesticides dispersed in the form fine liquid droplets in water and form oil-in-water (O/W) emulsions [39].
Diagrammatical representation showing key steps of emulsion in water formulation and its application.
Lambda-cyhalothrin is broad-spectrum synthetic pesticide widely being used to control diamondback moth, cabbage caterpillar, cotton bollworm, and other pests that damage main food crops such as vegetables, soybeans, peanuts, and cotton [40]. This pesticide is commonly used in Asian countries due to its moderate toxicity, high insecticidal activity, and a long-lasting effect. However, lambda cyhalothrin previously available as EC and ME formulations pollutes the environment, costly due to loads of surfactants and consume non-renewable resources in the form of petroleum solvents [41]. Therefore, there is an urgent requirement to replace these shortcomings to further take the benefit of this broad-spectrum pesticide.
EW formulations such as limonene, peppermint oil, and spearmint oil have been developed and bio-efficacy evaluation was done on
In addition to agricultural field pest control, EW formulation can also be used in preparation of postharvest packaging films with anti-insect property. Recently, cinnamon oil (CO) anti-insect packaging film has been developed for repelling
IPFT has contributed to Lambda Cyhalothrin EW, Chlorpyriphos 10 EW, etc. Recently, IPFT has optimized the neem EW formulation procedure by high shear mixing. The increase in shearing intensity reduced the droplet size and resulted in higher stability.
The combination formulations have broad-spectrum insecticidal activities and can be applied for insect control in different Asian countries. These mixed formulations have the user and environment-friendly applications over conventional formulations.
ZW (Capsulated Suspension (CS) + Emulsion in water (EW)
This formulation is the combination of two formulations with two different pesticides in water medium. In this, one pesticide is encapsulated inside the polymeric coating and other is in emulsified droplet form (Figure 12).
Diagrammatical representation of ZC formulation and its application.
IPFT has developed ZW combination formulation of capsulated suspension (CS) of Lambda cyhalothrin with concentrated emulsion in water (EW) of chlorpyriphos, and this combination was termed as ZW [7, 8]. Main advancement of this formulation is that it is the combination of two pesticides in two different formulations, one broad-spectrum pesticide, that is, in EW formulation for quick action and lambda cyhalothrin CS for controlled release and will be effective for extended period of time and give long-term pest control [45]. This combination formulation can be used for different pesticides with good compatibility index.
ZC formulation (Capsulated formulation (CS) + Suspension Concentrates (SC))
The ZC formulation is the stable aqueous suspension of polymeric-encapsulated microcapsules and solid-suspended fine particles of two different pesticides. Both formulations are homogeneously mixed by wet milling and gentle shear mixing (Figure 13).
Diagrammatical representation of ZC formulation and its application.
Chlorantraniliprole and thiamethoxam SC, lambda cyhalothrin and chlorantraniliprole ZC, thiamethoxam and lambda cyhalothrin ZC, beta-cyfluthrin and imidacloprid SC, and flubendiamide and thiacloprid SC efficacy have been evaluated against spotted pod borer. The study was found that ZC formulations gave superior results on the management of
In addition to enhanced bio-efficacy, this combination formulation has been investigated for non-targeted effects. ZC (thiamethoxam and lambda cyhalothrin under trade name Alika 247 bio-efficacy) was evaluated against Pest of Tea in West Bengal, India. The study reported that Alika 247 ZC was safe for the important natural predators found in the tea ecosystem relative to conventional formulations like EC [47]. Similarly, thiamethoxam and lambda cyhalothrin ZC impact was investigated on Population of Lady Bird Beetles in maize crop ecosystem in Gujarat, India [48].
This combination formulation has fast and quick knockdown and extended control of foliar insect pest. This formulation is basically developed for soybean aphids, Japanese beetle, grasshopper, corn rootworm beetle, stinkbugs, etc.
Institute of Pesticide Formulation Technology (IPFT) has developed Lambda cyhalothrin 14 CS with Diflubenzuron 10SC. The unique specialty of this developed ZC formulation is effective against early stages and adult stages simultaneously. The combined pesticide provides improved and synergistic activity. Besides this, formulation is suitable for immediate as well as for prolonged pest control practices.
Suspoemulsion (Suspension concentrate (SC) + Emulsion in water (EW))
Suspension (SE) is the combination of two active ingredients one in suspension concentrate (SC) and concentrated aqueous emulsion (EW) (Figure 14). Suspoemulsion is the stable colloidal suspension with fine droplets with a high degree of electrostatic, steric, and hydrophobic interactions and with lesser degree of Ostwald ripening [49].
Diagrammatical representation of suspoemulsion formulation and its application.
Main advancing features are different active ingredients with different solubility or melting points can be incorporated, providing broad-spectrum pest control, and tank mixing is not required. Suspoemulsions are the most convenient formulation for the farmers to apply the correct quantity of pesticides and tank mix incompatibility problems have been removed. Surfactants and thickeners were added in suspoemulsion to prevent flocculation and separation of the dispersed phases [50].
IPFT has contributed suspoemulsion of fipronil 5% SC + Soyabean oil as Adjuvant 5% EW. The main characteristic feature of this formulation is high stability and shelf life along with good bio-efficacy to agricultural pest in Asian countries.
Different bioactive phytochemicals have been identified for good bio-efficacy. These bioactive ingredients in formulated form will play a very significant role in promotion of organic farming in Asian countries in a safe and sound way. Followings botanical formulations have been formulated by IPFT.
New generation botanical-based formulations developed in IPFT, India, are as follows:
Institute of Pesticide Formulation Technology (IPFT), Gurugram in India is the only institute devoted for the development of safe and environment-friendly new-generation insecticide formulation technology. There are some new formulated products of natural insecticides such as controlled release formulations, nano-formulations, or water-based formulations, which enhance the efficacy of natural pesticides against insect pest. The work carried out at IPFT greatly emphasizes on the development and promotion of environment and user-friendly pesticide formulations, also biodegradable, with the incorporation of latest technologies, and also on their commercialization.
Currently, IPFT is working toward the development of safer alternatives to banned or going to be banned agrochemicals. Research is in the process of development to safer formulations with potentially low-risk user and environment-friendly novel formulation development of various broad-spectrum pesticides that are in the verge of banned have been attracting global attention. In this context, public and private sectors cooperation is necessary to facilitate the formulation development of safe and environment-friendly improved and advanced alternative. Novel formulations improve the delivery of agrochemicals and boost up the agricultural system in near future. Most important aspect along with the development is the cost of safe formulation. Maintaining low cost of novel formulations to farmers for a given product quality and availability, particularly in developing countries, is also important. Though, new formulation strategies could give out a very promising and potential option for pest control but to attain this objective, more field research is required to assess the efficacy on specific pest problems and over rising pest problems in various cropping systems. Therefore, it is a necessary requirement for strengthening the research in this safe and green formulation technology development.
Authors would like to thanks to Institute of Pesticide Formulation Technology under Ministry of Chemicals and Fertilizer, India. The authors would like to thank Dr. Saurabh Dubey for her valuable input in the preparation of this chapter.
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\\n\\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\\n\\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\\n\\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\\n\\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\\n\\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\\n\\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\\n\\n3. CORRESPONDING AUTHOR'S DUTIES
\\n\\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\\n\\n3.2 When submitting the Article, the Corresponding Author agrees to:
\\n\\n• Comply with all instructions and guidelines provided by IntechOpen;
\\n\\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\\n\\n• Submit all the corrections in due time as defined during the publishing process schedule.
\\n\\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\\n\\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\\n\\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\\n\\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\\n\\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n"}]'},components:[{type:"htmlEditorComponent",content:"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Journal Article:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Article who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author. Co-Author: All other Authors of the Article besides the Corresponding Author. IntechOpen: IntechOpen Ltd., the Publisher of the Journal.
\n\nJournal: The publication as a collection of Articles compiled by IntechOpen .
\n\nArticle: The original literary work created by Corresponding Author and any Co Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\n\n3.2 When submitting the Article, the Corresponding Author agrees to:
\n\n• Comply with all instructions and guidelines provided by IntechOpen;
\n\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\n\n• Submit all the corrections in due time as defined during the publishing process schedule.
\n\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\n\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\n\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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David Pan"},{id:"214068",title:"Mr.",name:"Yuhang",middleName:null,surname:"Dong",slug:"yuhang-dong",fullName:"Yuhang Dong"},{id:"214069",title:"Dr.",name:"Dongsheng",middleName:null,surname:"Wu",slug:"dongsheng-wu",fullName:"Dongsheng Wu"}]},{id:"5210",doi:"10.5772/6156",title:"Machine Vision: Approaches and Limitations",slug:"machine_vision__approaches_and_limitations",totalDownloads:6606,totalCrossrefCites:3,totalDimensionsCites:17,abstract:null,book:{id:"3765",slug:"computer_vision",title:"Computer Vision",fullTitle:"Computer Vision"},signatures:"Moises Rivas Lopez, Oleg Sergiyenko and Vera Tyrsa",authors:null}],mostDownloadedChaptersLast30Days:[{id:"70785",title:"Pedestrian Detection and Tracking in Video Surveillance System: Issues, Comprehensive Review, and Challenges",slug:"pedestrian-detection-and-tracking-in-video-surveillance-system-issues-comprehensive-review-and-chall",totalDownloads:1306,totalCrossrefCites:7,totalDimensionsCites:10,abstract:"Pedestrian detection and monitoring in a surveillance system are critical for numerous utility areas which encompass unusual event detection, human gait, congestion or crowded vicinity evaluation, gender classification, fall detection in elderly humans, etc. Researchers’ primary focus is to develop surveillance system that can work in a dynamic environment, but there are major issues and challenges involved in designing such systems. These challenges occur at three different levels of pedestrian detection, viz. video acquisition, human detection, and its tracking. The challenges in acquiring video are, viz. illumination variation, abrupt motion, complex background, shadows, object deformation, etc. Human detection and tracking challenges are varied poses, occlusion, crowd density area tracking, etc. These results in lower recognition rate. A brief summary of surveillance system along with comparisons of pedestrian detection and tracking technique in video surveillance is presented in this chapter. The publicly available pedestrian benchmark databases as well as the future research directions on pedestrian detection have also been discussed.",book:{id:"8465",slug:"recent-trends-in-computational-intelligence",title:"Recent Trends in Computational Intelligence",fullTitle:"Recent Trends in Computational Intelligence"},signatures:"Ujwalla Gawande, Kamal Hajari and Yogesh Golhar",authors:[{id:"312168",title:"Dr.",name:"Ujwalla",middleName:null,surname:"Gawande",slug:"ujwalla-gawande",fullName:"Ujwalla Gawande"},{id:"312350",title:"Mr.",name:"Kamal",middleName:null,surname:"Hajari",slug:"kamal-hajari",fullName:"Kamal Hajari"},{id:"312351",title:"Prof.",name:"Yogesh",middleName:null,surname:"Golhar",slug:"yogesh-golhar",fullName:"Yogesh Golhar"}]},{id:"58546",title:"Machine Learning in Educational Technology",slug:"machine-learning-in-educational-technology",totalDownloads:2436,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Machine learning is a subset of artificial intelligence (AI) that helps computers or teaching machines learn from all previous data and make intelligent decisions. The machine-learning framework entails capturing and maintaining a rich set of information and transforming it into a structured knowledge base for different uses in various fields. In the field of education, teachers can save time in their non-classroom activities by adopting machine learning. For example, teachers can use virtual assistants who work remotely from the home for their students. This kind of assistance helps to enhance students’ learning experience and can improve progression and student achievement. Machine learning fosters personalized learning in the context of disseminating education. Advances in AI are enabling teachers to gain a better understanding of how their students are progressing with learning. This enables teachers to create customized curriculum that suits the specific needs of the learners. When employed in the context of education, AI can foster intelligence moderation. It is through this platform that the analysis of data by human tutors and moderators is made possible.",book:{id:"6346",slug:"machine-learning-advanced-techniques-and-emerging-applications",title:"Machine Learning",fullTitle:"Machine Learning - Advanced Techniques and Emerging Applications"},signatures:"Ibtehal Talal Nafea",authors:[{id:"216001",title:"Dr.",name:"Ibtehal",middleName:null,surname:"Nafea",slug:"ibtehal-nafea",fullName:"Ibtehal Nafea"}]},{id:"68953",title:"Machine Translation and the Evaluation of Its Quality",slug:"machine-translation-and-the-evaluation-of-its-quality",totalDownloads:1480,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Machine translation has already become part of our everyday life. This chapter gives an overview of machine translation approaches. Statistical machine translation was a dominant approach over the past 20 years. It brought many cases of practical use. It is described in more detail in this chapter. Statistical machine translation is not equally successful for all language pairs. Highly inflectional languages are hard to process, especially as target languages. As statistical machine translation has almost reached the limits of its capacity, neural machine translation is becoming the technology of the future. This chapter also describes the evaluation of machine translation quality. It covers manual and automatic evaluations. Traditional and recently proposed metrics for automatic machine translation evaluation are described. Human translation still provides the best translation quality, but it is, in general, time-consuming and expensive. Integration of human and machine translation is a promising workflow for the future. Machine translation will not replace human translation, but it can serve as a tool to increase productivity in the translation process.",book:{id:"8465",slug:"recent-trends-in-computational-intelligence",title:"Recent Trends in Computational Intelligence",fullTitle:"Recent Trends in Computational Intelligence"},signatures:"Mirjam Sepesy Maučec and Gregor Donaj",authors:[{id:"305414",title:"Associate Prof.",name:"Mirjam",middleName:null,surname:"Sepesy Maučec",slug:"mirjam-sepesy-maucec",fullName:"Mirjam Sepesy Maučec"},{id:"309288",title:"Dr.",name:"Gregor",middleName:null,surname:"Donaj",slug:"gregor-donaj",fullName:"Gregor Donaj"}]},{id:"30663",title:"Intelligent Analysis of Utilization of Special Purpose Machines for Drilling Operations",slug:"intelligent-analysis-of-utilization-of-special-purpose-machines-for-drilling-operations",totalDownloads:6355,totalCrossrefCites:4,totalDimensionsCites:9,abstract:null,book:{id:"1931",slug:"intelligent-systems",title:"Intelligent Systems",fullTitle:"Intelligent Systems"},signatures:"Majid Tolouei-Rad",authors:[{id:"110340",title:"Dr.",name:"Majid",middleName:null,surname:"Tolouei-Rad",slug:"majid-tolouei-rad",fullName:"Majid Tolouei-Rad"}]},{id:"57822",title:"Regression Models to Predict Air Pollution from Affordable Data Collections",slug:"regression-models-to-predict-air-pollution-from-affordable-data-collections",totalDownloads:2048,totalCrossrefCites:9,totalDimensionsCites:11,abstract:"Air quality monitoring is key in assuring public health. However, the necessary equipment to accurately measure the criteria pollutants is expensive. Since the countries with more serious problems of air pollution are the less wealthy, this study proposes an affordable method based on machine learning to estimate the concentration of PM2.5. The capital city of Ecuador is used as case study. Several regression models are built from features of different levels of affordability. The first result shows that cheap data collection based on web traffic monitoring enables us to create a model that fairly correlates traffic density with air pollution. Building multiple models according to the hourly occurrence of the pollution peaks seems to increase the accuracy of the estimation, especially in the morning hours. The second result shows that adding meteorological factors allows for a significant improvement of the prediction of PM2.5 concentrations. Nevertheless, the last finding demonstrates that the best predictive model should be based on a hybrid source of data that includes trace gases. Since the sensors to monitor such gases are costly, the last part of the chapter gives some recommendations to get an accurate prediction from models that consider no more than two trace gases.",book:{id:"6346",slug:"machine-learning-advanced-techniques-and-emerging-applications",title:"Machine Learning",fullTitle:"Machine Learning - Advanced Techniques and Emerging Applications"},signatures:"Yves Rybarczyk and Rasa Zalakeviciute",authors:[{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk"},{id:"213065",title:"Prof.",name:"Rasa",middleName:null,surname:"Zalakeviciute",slug:"rasa-zalakeviciute",fullName:"Rasa Zalakeviciute"}]}],onlineFirstChaptersFilter:{topicId:"520",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. 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He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"24",type:"subseries",title:"Computer Vision",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. 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