\r\n\r\n
\r\n\r\nThis project was co-financed by the European Regional Development Fund under the Operational Programme "Innovative Economy".\r\n',isbn:null,printIsbn:"978-953-51-1734-6",pdfIsbn:"978-953-51-4230-0",doi:"10.5772/59798",price:119,priceEur:129,priceUsd:155,slug:"storage-stability-of-fuels",numberOfPages:278,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"bc73beb5dc74410e15c8ee19ee4de722",bookSignature:"Krzysztof Biernat",publishedDate:"February 4th 2015",coverURL:"https://cdn.intechopen.com/books/images_new/4751.jpg",numberOfDownloads:21921,numberOfWosCitations:25,numberOfCrossrefCitations:14,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:30,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:69,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 30th 2014",dateEndSecondStepPublish:"November 20th 2014",dateEndThirdStepPublish:"February 24th 2015",dateEndFourthStepPublish:"May 25th 2015",dateEndFifthStepPublish:"June 24th 2015",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:'
\r\n\tHydrogen gas has the potential to solve the growing energy crisis today due to its clean, renewable, high-energy-density, and non-carbon fuel properties. Hydrogen is a synthetic fuel that can be produced from various raw materials such as water, fossil fuels, and biomass using primary energy sources. During the production phase, there are many alternative production technologies such as steam recovery, waste gas purification, electrolysis, photo processes, thermochemical processes, and radiolysis. Hydrogen has a variety of uses, including nonpolluting vehicles, fuel cells, home heating systems, and aircraft. Furthermore, using hydrogen as an energy carrier is a long-term option for reducing global carbon dioxide emissions by obtaining high-value hydrocarbons through carbon dioxide hydrogenation. The costs of a hydrogen-based system, on the other hand, are still high. Therefore, research on hydrogen, which is abundant in nature, continues so that hydrogen-based systems, particularly for long-term energy storage, can become commercially attractive. The use of hydrogen energy as a complement to traditional energy sources also aids in the implementation of low-carbon solutions.
\r\n\r\n\tThis book invites chapters of research on technologies developed for the production, storage, and industrial applications of hydrogen. Recommendations to overcome challenges such as the high costs of hydrogen energy output, and the policies and promotions of policymakers to bring hydrogen to today's markets will be among the main topics of the book. Studies on the environmental effects of hydrogen energy production, life cycle analyses of methods, and related sustainable development goals will also be included.
\r\n\t
In December 2019, unexplained cases of pneumonia were reported from the epicenter of Wuhan City in China caused by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The transmissibility and virulence of this virus quickly transformed it into the worst global pandemic of our generation. The viral pneumonia syndrome was then named coronavirus disease 2019 (COVID-19) by World Health Organization. The COVID-19 pandemic continues to be a major cause of mortality and economic impact throughout the world. It is predominantly a respiratory disease, with a range of presentations varying from asymptomatic to severe respiratory failure. SARS-CoV-2 is known to enter human cells through angiotensin-converting enzyme 2, which is expressed not only in the lungs but also in other organs, such as the cardiovascular system, thus explaining the wide range of symptom manifestations. Significant concerns relating to COVID-19 and the cardiovascular system have been highlighted, with COVID-19 inducing multiple cytokines and chemokines resulting in vascular inflammation, plaque instability, and myocardial inflammation. Several biomarkers have been studied that have related to COVID-19 progression as well as short-term mortality [1]. Cardiac biomarker and their elevation in COVID-19 have been studied and shown as a reflection of myocardial injury, hemodynamic stress, higher burden of cardiovascular disease, and worse prognosis [2]. Cardiac biomarkers have been suggested as possible aids for clinicians treating COVID-19 and understanding the severity of the disease and prognosis of patients. In this chapter, we will discuss the pathogenesis, role of specific cardiac biomarkers, and their use in the prognosis and management of COVID-19.
The COVID-19 pandemic ranks as one of the most devastating events of the 21st century. Since 2019, the virus has spread rapidly across the globe with a reported case burden of upwards of 219 million with 4.5 million deaths. The United States of America, India, and Brazil reported the highest mortality among countries across the globe. The Centers for Disease Control and Prevention (CDC) estimates put the total number of COVID-19 cases in the United States at 44 million with 709,000 deaths. There is emerging data regarding the incidence and prevalence of cardiac injury in COVID-19 infection. Systematic reviews and meta-analyses have shown wide-ranging results. One meta-analysis demonstrated a 19% prevalence of cardiac injury in total COVID-19 cases, with 36% prevalence in severe cases, and 48% prevalence in non-survivors. Another meta-analysis showed a cardiac injury prevalence of 7.2% in total COVID-19 survivors, and 77% in non-survivors. While further analysis needs to be carried out to establish a more accurate prevalence of cardiac injury in COVID-19 infection, the prevalence of cardiac injury tends to increase along with the severity of the infection and poorer prognosis.
The pathobiology of elevation of cardiac enzymes in patients with COVID-19 can be divided into two major categories: (1) direct damage to the heart by downregulation of ACE2, microvascular dysfunction, pericyte injury, and hypoxemia causing: myocarditis, heart failure, arrhythmias; and (2) indirect damage of cytokine storm by the release of cytokines, hyper inflammation, insulin resistance, coagulopathy causing: myocarditis, metabolic effect, thromboembolism. These are elucidated in Figures 1 and 2. Potential mechanisms of myocardial injury in COVID-19 include binding of the SARS-CoV2 virus to the endothelial angiotensin-converting enzyme 2 (ACE-2) receptor [3]. Given the low overall expression of angiotensin-converting enzyme 2 receptor in myocardial cells, the tropism of severe acute respiratory coronavirus 2 for the heart may be less likely. Myocardial injury has been reported in 36% patients hospitalized with COVID-19. Although clinical COVID-19 cases with myocardial injury and normal coronary arteries have been thought to be caused by myocarditis, ST-segment elevation myocardial infarctions (STEMI) may be caused by extensive microvascular thrombosis in the absence of epicardial coronary obstruction. On the other hand, indirect injury can occur as a consequence of a proinflammatory state, stress cardiomyopathy, and tachyarrhythmia attributable to endogenous or exogenous adrenergic stimulation. Systemic infections such as pneumonia have a profound effect on the cardiovascular system, including an increase in oxygen consumption and coronary plaque vulnerability. Myocardial involvement caused by cytokine storm or cardiomyocyte apoptosis triggered by excessive intracellular calcium in response to tissue hypoxia constitutes the indirect response of COVID-19 [4]. Myocardial ischemia occurs in the setting of shock, prolonged tachycardia, or severe respiratory failure, known as type 2 acute myocardial injury (AMI) or acute atherothrombosis, known as type 1 AMI. Type 1 myocardial infarction occurs in the setting of atherothrombosis, which may be triggered by a proinflammatory and prothrombotic state. Type 2 myocardial infarction is most likely in patients with prolonged oxygen supply or demand imbalance with hypoxia, hypotension, or tachycardia. Finally, both myocarditis and takotsubo syndrome have been reported in patients with confirmed COVID-19 and in those without COVID-19 who had experienced severe anxiety due to the pandemic or with concomitant infections.
Cardiac phenotypes of manifestations of COVID-19.
Mechanisms of cardiac Injury of COVID-19 with clinical sequelae.
Cardiac troponin (cTn) is a well-studied and commonly used marker of cardiovascular disease. Troponin is a calcium-regulatory protein for the calcium regulation of contractile function in skeletal and cardiac muscles. Troponin is a complex of three different subunits, troponins C, I, and T, which share characteristic functions of troponin, such as the binding of Ca2+ (troponin C), the inhibition of actomyosin interaction (troponin I), and the binding to tropomyosin (troponin T). Troponin is nearly undetectable in unaffected muscle, but troponin levels rise several hours after the onset of myocardial injury. Elevated levels of troponin have been used as a widely accepted marker of cardiac injury. It is detectable up to 10 days after the onset of injury. The degree of elevation of troponin also gives prognostic information on the subsequent outcome as seen in Figure 3. Cardiac troponin I levels of 1.0 μg/L or higher or cardiac troponin T levels of 0.1 μg/L or higher are considered elevated. Circulating cTn is a marker of myocardial injury, including but not limited to myocardial infarction or myocarditis. There has been growing evidence of higher mortality rates among patients among those patients with underlying cardiovascular disease. The values of cardiac troponin and its elevations above normal concentrations in a patient with COVID-19 should be seen as the combination of the presence or extent of pre-existing cardiac disease and the acute myocardial injury related to COVID-19 and its complications. It further acts as a quantitative marker of this injury. It has been proposed that there are three phases of troponin elevation: first, when cardiac troponin increases mostly reflect ongoing comorbidities, commonly seen at the time of are admission; second, with a critical illness like ARDS; third, specific COVID-19 complications such as pulmonary embolism, stroke, endothelitis and myocarditis. Patients with COVID-19 admitted to the hospital, at 30-day follow up with higher cTn (concentrations greater than ≥21 ng/L) have been associated independently with a higher risk of all-cause mortality. Cardiac troponin elevations, even in small amounts (≥21 ng/L) provide a better prediction of 30-day all-cause mortally and severe course of the disease than other commonly used biomarkers for inflammation including C-reactive protein (CRP), lactate dehydrogenase (LDH), and D-dimer. Furthermore, greater elevations (cTn > 90 ng/L) correlate with higher risk of death than small concentrations (cTn > 30–90 ng/L). Patients with cTn concentrations in the third centile had about six times the all-cause mortality as well as cardiovascular mortality as compared to patients in the first tertile. Higher troponin concentrations are also related to a higher risk of death within 30 days as well as 2 years. Concentrations remained in the normal range in the majority of survivors. High sensitivity troponin I (hs-TnI) is a newer, more sensitive marker of disease progression and mortality in patients with cardiac disease [5]. It was established to be a better marker than those used to determine generalized inflammation including D-dimer and lymphocyte count. Raised hc-TnI in patients admitted with COVID-19 has also been showed to correlate with increased requirements of invasive as well as non-invasive ventilation, development of acute respiratory distress syndrome (ARDS) as well as acute kidney injury (AKI). Studies revealed that the elevated hs-TnI levels were closely correlated with the prognosis and mortality risk of COVID-19 patients. Specifically, the mortality risk increased by 20.8% when the hs-TnI level increased by 1 unit in one such study. However, it is noteworthy to remember that elevated levels are common in hospitalized patients, and are most commonly in the setting of type 2 myocardial infarction (myocardial oxygen supply-demand imbalance) or non-ischemic causes of myocardial injury. Marked elevations of cardiac troponin in patients without critical illnesses such as ARDS, may indicate the presence of takotsubo syndrome, myocarditis, or type 1 AMI triggered by COVID-19. In the absence of symptoms or electrocardiographic changes suggestive of type 1 acute myocardial injury, imaging studies including echocardiography and/cardiac magnetic resonance should be considered to detect left ventricular systolic dysfunction as a new and treatable condition. Patients with symptoms suggestive of type 1 AMI should be treated according to European Society of Cardiology (ESC) guidelines irrespective of COVID-19 diagnosis or suspicion. These patients should undergo rapid coronary angiography under specific catheter personnel. Patients with COVID-19 or other pneumonia who are critically ill with septic shock or ARDS, even marked cardiac troponin elevations are much more likely the consequence of critical illness. The recognition of myocardial injury with elevated cardiac troponin and hs-TnI, given its sensitivity as an early and precise marker of end-organ dysfunction, can prompt timely triage to a critical care unit and informs the measures to improve tissue oxygenation and perfusion with the use of inotropes and vasopressors. Further research is required to elucidate the value of cardiac troponin and high sensitivity troponin I in COVID-19.
Relationship of troponin T and expected probability of death.
Creatine Kinase (CK) is an intracellular enzyme present primarily in skeletal muscle, myocardium, and brain. Disruption of cell membranes due to hypoxia or other injury releases CK from cytosol to systemic circulation. CK is a dimeric molecule composed of 2 subunits, namely M and B. Combinations of these subunits form the isoenzymes CK-MM, CK-MB, and CK-BB. A significant concentration of CK-MB isoenzyme is found almost exclusively in the myocardium, and therefore elevations in CK-MB levels in serum is highly specific and sensitive for myocardial injury. Normal reference values for CK-MB range from 3 to 5% of total CK, or 5 to 25 IU/L. Creatine Kinase as a marker of myocardial injury has been largely replaced by troponin in clinical practice. As with troponins, several mechanisms explain the elevated cardiac markers in severe COVID-19: viral myocarditis, cytokine-driven myocardial damage, microangiopathy, and unmasked CAD. Myocardial ACE2 receptors are targets for SARS-CoV-2. A hypothesis is that SARS-CoV-2 induces indirect cardiovascular injury through activation of the immune system. The virus attaches to the pattern recognition receptors (PRRs), that initiate host-immune defense. This host-immune defense system, in turn, induces inflammatory reactance that culminates in a cytokine storm. The cytokine storm is caused by the release of reactive oxygen species (ROS), endogenous nitric oxide (NO), and damage-associated molecular proteins (DAMPs) by the injured myocardium that ultimately leads to myocardial injury. Cytokines and host-immune dysregulation cause direct and indirect cardiac injury, leading to an increase in troponin and CK-MB. A meta-analysis showed that when compared with mortality, COVID-19 patients who died had significantly higher biomarkers, including CK-MB. Another meta-analysis showed that there was a significantly higher CK level in patients who died compared to patients who survived, whereas the patients who were critically ill did not have significantly higher CK levels compared to the patients who were not critically ill.
Natriuretic peptides represent a change of intracardial pressure, especially atrial pressure, and thus is also used as an important cardiac function indicator. These include Brain-type natriuretic peptide (BNP), NT-proBNP, and mid-regional pro atrial natriuretic peptide. Nartiuretic peptides are trigger by hemodynamic stress and heart failure, intracardiac filling pressures, end diastolic wall stress, and hypoxemia. In patients who are not critically ill, BNP/pro-BNP elevations have a high positive predictive value for heart failure. However, in patients who are critically ill, the elevations are likely in the presence of hemodynamic stress and heart failure. Several studies have identified heart failure as a significant manifestation of COVID-19. Heart failure in COVID-19 patients is postulated to occur as a result of the severe immune system reaction and cytokine storm [6, 7]. The virus downregulates the angiotensin-converting enzyme 2 (ACE2), leading to increased levels of angiotensin II. Further, this causes increased inflammation, thrombosis, and hypertension. Abnormalities NT-proBNP, were associated with higher in-hospital mortality in all patients and in severe patients. Studies were done to estimate the cumulative in-hospital mortality among patients severe COVID-19 patients. The mortality rates were the highest with elevated hs-cTnI and NT-proBNP, followed by elevated NT-proBNP and normal hs-cTnI, elevated hs-cTnI and normal NT-proBNP, and normal hs-cTnI and NT-proBNP. The combination of these two cardiac markers together was found to be more valuable than cardiac troponin alone in determining the prognosis of COVID-19 patients. There has been one retrospective study that reported a correlation between first and peak BNP values to predict the need for mechanical ventilation and mortality respectively. Pro-BNP levels elevated above 167.5 pg./mL are associated with an increased risk of mortality in patients receiving mechanical ventilation. Furthermore, along with the strong association of mortality in patients admitted to the hospital with COVID-19, the elevation of natriuretic peptides could be used as an early indicator for the presence of left and right ventricular systolic dysfunction independently. Identification of ventricular systolic dysfunction, if a treatable dysregulation, will help in decreased mortality and improved outcomes in patients.
ADM is a multipotent regulatory peptide with several biological activities including vasodilator, positive inotropic, diuretic, natriuretic, and bronchodilator. It is widely expressed throughout the body, including bone, adrenal cortex, kidney, lung, blood vessels, and heart. ADM is even present in pulmonary pneumocytes type 2, smooth muscle cells, neurons, and immune cells. It is upregulated by hypoxia, inflammatory cytokines, bacterial products, and shear stress. As ADM measurement is complicated, mid-regional proadrenomedullin (MR-proADM) is being considered as an estimate of ADM [8, 9, 10]. High levels of MR-proADM are reported in septic patients. These have been shown to be particularly specific in prognostic value, not only for early diagnosis in the context of patients initially presenting to the Emergency Department (ED) but also for risk stratification and prognosis in critically ill patients in Intensive Care Units (ICU). A study from Italy in 2020 aimed to describe the utility of MR-proADM as a prognostic biomarker in severe COVID-19 infection. Fifty seven patients who were admitted to the ICU with COVID-19 infection were studied. Multivariate logistic regression models demonstrated that MR-proADM was an independent predictor of mortality [11].
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor β superfamily and is widely distributed in low concentrations in most organs [12]. Physiological GDF-15 concentrations increase with age, while the expression is upregulated in pathological states through several pathways that mediate damage to the heart, lungs, liver, and kidneys including inflammation, oxidative stress, and hypoxia. Elevated concentrations of circulating GDF-15 have been identified in multiple disease entities like CVD, sepsis, cancer, and diabetes. GDF-15 levels seem to be a robust predictor of disease progression.
A clinical trial from Norway in 2020 looked at the value of GDF-15 as a biomarker in 123 patients admitted with COVID-19, GDF-15 was elevated in 80% of patients hospitalized with COVID-19, and higher concentrations were associated with SARS-CoV-2 viremia, hypoxemia, and worse clinical outcome. Moreover, GDF15 concentrations were more closely associated with poor outcomes than established biomarkers in COVID-19, including cTnT, NT-proBNP, CRP, and D-dimer. Greater increases in GDF-15 during hospitalization were also independently associated with worse outcomes.
The prognostic role of cardiac markers in patients hospitalized with COVID-19 is remarkably similar to those in patients with viral pneumonia due to influenza, as well as for pneumonia and ARDS in general in addition to certain unique characteristics. Increased concentrations of cTn, hs-TnI, pro-BNP have been showed to have a correlation with increased mortality and severity of COVID-19 pneumonia [13]. Mild elevations in cardiac troponin concentrations, particularly in older patients with pre-existing cardiac disease, are often explained by the combination of known or unknown pre-existing cardiac disease and acute myocardial injury related to COVID-19 or any pneumonia [14, 15]. It is imperative to be aware of the potential use of anticoagulants and anti-cytokine therapies as conceivable therapeutic options, which need to be further explored in clinical trials. In such cases, when there is evidence of cardiac injury as indicated by elevated troponins, possibilities such as myocardial microthrombi should be considered. In patients with established or suspected COVID-19 normal hs-cTnT/I and BNP/NT-proBNP concentrations, of course always in conjunction with vital parameters including pulse oximetry, can reassure physicians that outpatient management is feasible [16]. These insights can help overcome the limitations in determining the prognosis and stratification of patients as well as predicting their mortality. The cardiovascular system has been shown to be a major contributor to the proportion of deaths classified as “non-cardiovascular” by current classification schemes. An example of this is severe sepsis, mortality rates of which have a high contribution from dysfunction of the cardiac system, determined by the enzymes discussed above. Various other cardiac and vascular biomarkers are being studied in ongoing COVID-19 research. An example of this is the emerging data that growth differentiation factor 15 (GDF-15), a member of the transforming growth factor β superfamily that is released by stress due to change in hemodynamics as well as inflammation has better prognostic accuracy than established biomarkers in patients with COVID-19.
Cardiac troponin provides incremental prognostic information, only in addition to other routinely available variables. These include vital signs, clinical judgment, and other inflammatory markers such as C-reactive protein and D-dimer. Moreover, the increased implementation of these markers, such as elevated cardiac troponin in routine practice might result in inappropriate diagnostic and therapeutic interventions [17]. For example, some clinicians may elect to perform a coronary angiography in the setting of an isolated cardiac troponin elevation. These elevations would likely be in the setting of supply-demand imbalance, and less likely due to type 1 acute myocardial injury. These increased interventions also serve as a possible cause for increased harm to patients as well as the medical care team due to increased exposure to COVID-19 patients. Even non-invasive investigations may be associated with the harm caused due to the risk associated with unnecessarily transporting critically ill patients through the hospital. Hence, firm indications for testing are advocated for [18]. However, when appropriate indications are present, one should not withhold essential evaluations. There is concern that measuring cardiac troponin during the initial blood sampling in the ED may delay patient disposition, as elevated levels require additional investigation, and possibly consultation. In patients with COVID-19 and patients with ARDS, there is currently no evidence that any intervention triggered by an elevation in cardiac troponin concentration will have an impact on patient outcomes.
As we continue to learn about COVID-19 and its cardiac consequences, widespread use of cardiac markers in routine clinical practice will increase large datasets leading to better clinical characterization, cardiac imaging, and follow up leading to a better understanding of the pathophysiological mechanisms leading to cardiomyocyte injury in COVID-19. As blood tests are routinely done on patients hospitalized with COVID-19, cardiac biomarkers are easy, cost-effective and accessible method of screening for cardiac complications of COVID-19 and determining the overall prognosis of COVID-19 patients.
In patients with COVID-19 presenting with chest discomfort or dyspnea, cardiac troponin, myoglobin, natriuretic peptides, help physicians in the initial assessment.
Small increases in cardiac troponin concentrations are frequently seen and have multiple causes including myocardial oxygen supply-demand mismatch, myocarditis, and a systemic inflammatory response syndrome.
Compared with other biomarkers, elevated peak troponin I had the greatest predictive value for mortality associated with COVID-19.
If there is clear evidence of myocardial ischemia considering all available evidence, patients should be managed as acute coronary syndromes.
Cardiac troponin, creatinine kinase, and natriuretic peptide are indicated as valuable tests in patients with worsening COVID-19.
When people are asked why health is important, many are unable to answer it. The reason for this may be due to their lack of awareness of the importance of health and the consequent lack of proper self-care. Health can generally be considered an essential basis of life, but many people still do things that show that health is not a priority in their lives. They spend a lot of time on the opportunities they find but do not spend time learning what is good for them to exercise or stay healthy; they spend their budget on Nonsignificant things. But for a more nutritious diet, they pay less.
According to the World Health Organization’s definition, health is a state of complete physical, mental and social well-being and not only the absence of disease or infirmity. This definition of health has been given more attention since 1978 at the UN Summit in Almaty. Due to the considerable differences in the level of health in different countries of the world, the members of this organization were required to provide Primary Health Care by providing an essential package aimed at reducing the health gap between different countries and with the goal of Health for All by the year 2000. Undoubtedly, one of the most critical concerns and challenges that different countries have faced in providing primary health care to their population has been the lack of resources in the face of the growing need to receive this care during all these years.
So from the perspective of health economists, health is a durable good, or type of capital, that provides services. The flow of services produced from the stock of health capital is consumed continuously over an individual’s lifetime. Each person is assumed to be endowed with a given stock of health at the birth time, such as a year. Over the period, the stock of health depreciates with age and maybe promoted by investments in Health services. Death occurs when an individual’s stock of health falls below a critical minimum level.
To request a product or service, you must ask for it, afford it, and have a specific plan for purchasing it. Desires are, in fact, the unlimited desires and inclinations that people have for goods and services. Imagine being able to afford something if you could afford it or it was not so expensive. When we make choices, scarcity guarantees that many of our desires will never be met. Demand reflects our plan and vision for the demands that will be met. The amount of goods and services that the consumer plans to buy depends on many factors: commodity prices, related commodity prices, personal income, expected future prices, population, advertising, and preferences.
We must first discuss the relationship between the demand for a good or service and the price. All other factors influencing demand must be kept constant to study this relationship called the Citrus Paribus principle. The demand for a good or service is inversely related to its price; as the price increases, the demand for it decreases, and vice versa. Of course, the rate of demand response to price changes is not the same for all goods, which will be discussed in the topic of elasticity [1].
The demand curve is a geometric location of points where the dependent variable is the rate of use of a good, and the independent variable is the price of that good; in general, the demand curve shows the maximum demand for a good at different prices and also represent the ultimate price for a certain amount of a good. Usually, the price variable is shown on the y axis and the amount of goods or services on the x-axis (Figure 1).
Demand curve.
This shows the maximum amount someone is willing to pay for a small increment in consumption rate. Care should be taken in using the “demand” to mean the amount of consumption of a particular good or service at a specific price and to use it to mean a range of corresponding values in the price range (for example, one point on the demand curve versus the whole Points on the curve). The demand for a good or service is a function of its relative price and buyers’ income. The demand curve is a two-dimensional representation of this process. Responding to price changes is moving along the demand curve and responding to changes in revenue as the entire demand curve changes and shifts (Figure 2). Some of the characteristics of the demand side that should always be kept in mind when using the demand curve in healthcare, especially when making normative statements about well-being, are: Uncertainty on the part of the consumer about the likelihood of future illness; Side effects, the effectiveness of treatment methods and their possible cost. When sick, people experience anxiety, disability, suffering, and pain that may not be considered in the theory of desirability; It is also important to note that there may be an external demand for care and treatment of a person in addition to their need; And the fact that the price at which the applicant responds to the service or goods may in no way be an accurate reflection of the final cost of providing that product or service to the service provider.
Change in demand curve.
We can also consider the demand curve as a payment ability curve that measures the ultimate benefit. This curve shows the highest price a person is willing and able to pay for the last unit purchased. If there are fewer goods available, the highest price that a person is willing and able to pay for a larger unit will be high. But as the quantity of available goods increases, the ultimate benefit of each additional unit decreases, and the highest price offered on the demand curve decreases.
In addition to the price of the product in question, which is inversely related to the demand for that product, we can examine the relationship between the demand for a product and other factors in the space of the demand curve.
A complementary good is a good that is used with another commodity, and if the price of one of these commodities increases, in addition to the demand for that commodity, the demand for the other commodity also decreases.
Medical care consists of countless goods and services that maintain, improve, or restore a person’s health. For example, a young man may have wrist surgery to repair a torn tendon so he can return to work, an older woman may have cataract surgery to improve her vision, or a parent may have to Bring their child to a healthcare center for an annual dental checkup to prevent future problems. Prescription drugs, prescription glasses, and dentures are examples of medical supplies, while surgeries, periodic physical examinations, and visits to medical professionals are examples of medical services. Preventive and medical care are heterogeneous, making it difficult to measure and quantify medical care units accurately. Medical care services have four characteristics that distinguish these from other goods and services: intangibility, inseparability, inventory, and inconsistency.
Intangibility means that the five senses are incapable of evaluating medical services. Unlike new shoes, a vegetable salad dinner, or a new cell phone, the consumer cannot see, taste, or touch medical services. Indivisibility also means that the production and consumption of a medical service take place simultaneously. For example, when you see an ophthalmologist for an examination, you use ophthalmic services right at the time of production. In addition, a patient is often seen as both a producer and a consumer. Inventory is directly related to inseparability. Because the production and consumption of a medical service occur simultaneously, healthcare providers cannot store or maintain medical services. For example, a physiotherapist cannot provide a list of different physiotherapy services to meet demand during busy times. Finally, inconsistency means that the variety, composition, and quality of medical services are very different. Although different people may see a doctor simultaneously, there are various reasons for visiting a doctor. One person may see a doctor because of a typical physical problem, while another may see a doctor because of a heart attack. The combination of prescribed medical care or the frequency of its use can vary significantly from person to person and at different times [4, 5].
The following factors affect the demand for healthcare:
Needs (based on patient perception)
Patient preferences
Price or cost of use
Income
transportation cost
waiting time
Quality of care (based on patient perception)
The use of healthcare depends on demand and availability. If planners allocate resources based on need rather than demand, they may find themselves in a situation where some services are underused, and some services are overused.
Just as the healthcare market is different from other commodities, so is the demand for healthcare different from the simple demand model. One of the differences is that healthcare is not demanded because it is self-satisfying. After all, healthcare itself does not lead to satisfaction. Instead, healthcare is in demand because people are satisfied with their activities when they are healthy. So the demand for healthcare is a derived demand.
Patients’ perceptions of their need and capacity to benefit from healthcare are strongly influenced by physicians and healthcare providers. Although in economics, it is assumed that consumers can make informed decisions about their consumption patterns, healthcare consumers delegate this decision-making power to healthcare workers who are more aware of them. This phenomenon is due to information asymmetry between healthcare providers and patients, which carries the risk of induced demand by providers to increase revenue. Another complication stems from the fact that healthcare is highly heterogeneous. Each patient has a relatively different combination of pain and symptoms. Therefore each patient needs to purchase a fairly different package of care that both the patient and the physician have uncertainty about its effectiveness in meeting the need.
Another critical difference is that many health services are paid for by third parties. Payments by third parties or insurance companies Although they significantly increase people’s purchasing power for healthcare, it is also important to note that they can lead to ethical risks and increase demand for services that patients may not need.
Demand for healthcare depends on the level of consumption of an individual in case of illness; the amount of consumption can differ according to the factors affecting the demand, such as income, service price, education, norms, social traditions, and quality. A person’s decision to use or use services is related to his or her illness/injury status rather than healthcare. Developing countries are focused on promoting healthcare as an essential policy to improve health outcomes and fulfill international obligations and universal coverage of health services. However, many policies have focused more on improving physical access than on the demand-side healthcare needs pattern. In low-income countries, allocating scarce financial resources is based on clear criteria for the impact of investment in the health sector on service demand.
In these countries, due to the lack or weakness of social security systems, the occurrence of the disease leads to increased health costs and reduced labor productivity and leads to a loss of household welfare. In developed countries, due to insurance, many health services are used with minimal consumer participation in the payment; however, in developing countries, concerns about less use of health services, to the extent of supply. Or poor access is associated. However, even in health services, due to various barriers on the demand side, related to the cost of treatment, travel costs, and quality of services, the rate of exploitation is low. Also, the importance of a person’s health status in a clinical context is related to the analysis and social evaluation of a person’s health and social environment. Studies have shown that the risk of death is related to people’s perception of the health importance of maintaining it. Since one of the priorities of health policymakers is to improve people’s health, various factors that directly and indirectly affect the demand for health services should be examined more carefully. Identifying the factors influencing individuals’ decision to request healthcare services and choosing from different providers. Therefore, evaluating the determinants of demand for health services will introduce and implement appropriate incentive schemes to encourage better health services. Because health is one of the essential components of human capital and healthy human beings are the center of sustainable development, health can significantly increase the ability of individuals to perform various activities, including productive activities. As a result, people are looking for health. At the individual level, health is mainly influenced by multiple factors such as biological factors, lifestyle, purchased non-medical services, purchased medical services and goods, and different socio-economic characteristics. People’s understanding and expectation of healthcare quality are essential because the perceived quality of health services often affects health services’ behavior and consumption patterns [6].
Grossman used human capital theory to explain the demand for healthcare. According to human capital theory, people invest in themselves through education and health to increase their income. Grossman proposed an approach in which many important aspects of the demand for health services differ from the traditional demand approach:
That consumers are looking for health and demand health services to achieve it.
To achieve health, consumers buy health services from the market and combine them with their efforts to improve health, such as diet and exercise.
The health gained lasts more than a period and is not immediately depreciated to be analyzed as a capital good.
Most notably, health can be considered as both a consumer good and a capital good. From the people’s point of view, health is a consumer product because it makes them feel better. As a capital good, it is also suitable for people’s health because it increases the number of healthy days of life to work and earn money. Figure 3 provides a simple diagram that explains the concept of health capital. Just as one thinks that cars or laptops are capital goods that use the flow of their services over time, one can also understand the savings of one’s health capital, the outcome of which is “healthy days”. Outflow may be considered as one dimension of healthy days or measured in several dimensions of physical, mental health, and limited activity. People consume a range of health inputs, including healthcare inputs, diet, exercise, and time, so they invest in health savings. These investments help maintain or improve consumers’ health reserves, providing them with healthy days. Over time, health reserves may either grow, remain constant, or decrease with age due to illness or injury. As mentioned in Box 3, many technologies may generate health capital, using different amounts of time or health goods and services. Figure 3 shows how the ultimate goal of “healthy days” guides consumer decisions about the amount, time, and cost of investing in health storage. We will see that the prices of healthcare, the rate of wages of individuals, and their productivity in the production of health determine how resources are allocated between health capital and other goods and services that people buy. Consider a consumer who buys market inputs (e.g., medical care, food, clothing) and combines them with his or her own time to generate a health capital reserve that increases his or her utility [2].
Investing in health.
As an economic principle, the price of a good and the demand for that good are inversely related. That is, the higher the price of a commodity, the less demand there is for that commodity, and the lower the price of a good, the greater the demand for it. Price elasticity of demand shows that a one percent change in a good price causes a few percent changes in the demand. For example, if the price of a car rises by one percent, the demand for it will fall by a few percent, and vice versa, if the price of a vehicle falls by one percent, the demand will increase by a few percent.
Three things can happen when we calculate the price elasticity for a commodity:
When a one percent change in the price of a commodity occurs, the demand for that commodity changes by more than one percent. These types of goods are very price sensitive.
When a one percent change in a good price causes the demand for that good to change by less than one percent, this type of product is called inelastic. Demand for this type of goods shows a mild reaction to price changes.
The third case is when a one percent change in the price of a good causes a one percent change in the demand for that good.
If there is an inverse relationship between price and demand, demand elasticity will always be negative because the percentage change in one face or denominator is a negative fraction. Therefore, after calculating the price elasticity of demand, if the result, regardless of the negative sign of the number, becomes more than one, the commodity with elasticity is less than one, the good without elasticity, and if it is equal to one, the good has a single elasticity.
Although the price elasticity of a commodity can be determined only by collecting price information and calculating, some factors affect this ratio.
Alternative goods: The more alternative goods there are, the higher the price elasticity of that product. That is, when the price changes, the demand for that product changes more drastically. Also, price changes in a product cause a shift in the demand for alternative goods. In the healthcare sector, there are usually few alternatives to a health or medical intervention.
Complementary goods: When a product has a supplement, a change in the price of a complementary product causes a change in the demand for another product. Maternal and child care can be mentioned as complementary goods in the field of health (Figure 4).
Types of elasticity.
Commodity prices: In general, if the price of a commodity is very low, the amount of demand does not react to price changes. But high-priced products are attractive. On the other hand, different results are obtained depending on the price at which the demand elasticity is calculated. As mentioned initially, the price of a product has an inverse relationship with the amount of demand. When the price is precisely in the middle of the demand curve of a commodity, the commodity has a single elasticity. Also, if the price is less than the midpoint, the product in that range is unattractive. If the price is above the midpoint, the product will be pulled. You can see this in the chart below.
Marginal modes in demand elasticity.
Ove Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.
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\\n\\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\\n\\nKlijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\\n\\nKompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\\n\\nStranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\\n\\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
\\n\\nOsim ako nije suprotno navedeno, IntechOpen i/ili svi davatelji licence vlasnici su intelektualnog vlasništva nad svim materijalima na www.intechopen.com. Sva prava intelektualnog vlasništva su pridržana. Stranice sa www.intechopen.com možete gledati, preuzimati, dijeliti, dijeliti poveznice i printati za osobnu uporabu, a temeljem pravila sadržanih u ovim Odredbama i uvjetima.
\\n\\nMi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
\\n\\nIntechOpen ili njegovi suradnici niti u jednom slučaju neće biti odgovorni za štete (štete uključuju gubitak podataka ili profita, druge poslovne prekide, te sve ostale štete) koje nastanu zbog korištenja materijala na IntechOpenovoj stranici ili nemogućnosti da se iste koriste, čak i ako je IntechOpen ili njegov predstavnik o takvoj šteti obaviješten pismenim ili usmenim putem. Neke jurisdikcije ne dozvoljavaju ograničenja garancija ili ograničenja obveza za posljedične ili slučajne štete pa se u tom slučaju ova ograničenja možda ne odnose na vas.
\\n\\nMaterijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
\\n\\nIntechOpen nije formalno povezan niti s jednom vanjskom stranicom čije poveznice vode na www.intechopen.com, osim ako to nije izravno navedeno. Iz tog razloga IntechOpen nije odgovoran za sadržaj koji se pojavljuje na takvim stranicama. Poveznica na IntechOpenovu stranicu ne implicira povezanost sa IntechOpenom. Korištenje takvih poveznica isključiva je odgovornost korisnika.
\\n\\nZadržavamo pravo vlasništva nad cjelokupnom stranicom www.intechopen.com i nad svim materijalom na toj stranici. Koristeći se našim uslugama, slažete se da maknete sve poveznice na našu stranicu odmah nakon što to od vas zatražimo. Također, zadržavamo pravo da ove Odredbe i uvjete, i politiku o poveznicama izmjenimo u bilo koje vrijeme. Koristeći se poveznicama na naše stranice slažete se s ovim Odredbama i uvjetima.
\\n\\nAko smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\\n\\nBez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\\n\\nIntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\\n\\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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\n\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\n\nKlijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\n\nKompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\n\nStranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\n\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
\n\nOsim ako nije suprotno navedeno, IntechOpen i/ili svi davatelji licence vlasnici su intelektualnog vlasništva nad svim materijalima na www.intechopen.com. Sva prava intelektualnog vlasništva su pridržana. Stranice sa www.intechopen.com možete gledati, preuzimati, dijeliti, dijeliti poveznice i printati za osobnu uporabu, a temeljem pravila sadržanih u ovim Odredbama i uvjetima.
\n\nMi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
\n\nIntechOpen ili njegovi suradnici niti u jednom slučaju neće biti odgovorni za štete (štete uključuju gubitak podataka ili profita, druge poslovne prekide, te sve ostale štete) koje nastanu zbog korištenja materijala na IntechOpenovoj stranici ili nemogućnosti da se iste koriste, čak i ako je IntechOpen ili njegov predstavnik o takvoj šteti obaviješten pismenim ili usmenim putem. Neke jurisdikcije ne dozvoljavaju ograničenja garancija ili ograničenja obveza za posljedične ili slučajne štete pa se u tom slučaju ova ograničenja možda ne odnose na vas.
\n\nMaterijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
\n\nIntechOpen nije formalno povezan niti s jednom vanjskom stranicom čije poveznice vode na www.intechopen.com, osim ako to nije izravno navedeno. Iz tog razloga IntechOpen nije odgovoran za sadržaj koji se pojavljuje na takvim stranicama. Poveznica na IntechOpenovu stranicu ne implicira povezanost sa IntechOpenom. Korištenje takvih poveznica isključiva je odgovornost korisnika.
\n\nZadržavamo pravo vlasništva nad cjelokupnom stranicom www.intechopen.com i nad svim materijalom na toj stranici. Koristeći se našim uslugama, slažete se da maknete sve poveznice na našu stranicu odmah nakon što to od vas zatražimo. Također, zadržavamo pravo da ove Odredbe i uvjete, i politiku o poveznicama izmjenimo u bilo koje vrijeme. Koristeći se poveznicama na naše stranice slažete se s ovim Odredbama i uvjetima.
\n\nAko smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\n\nBez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\n\nIntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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by"}}]},subject:{topic:{id:"1384",title:"Theriogenology",slug:"veterinary-medicine-and-science-pathology-theriogenology",parent:{id:"302",title:"Pathology",slug:"veterinary-medicine-and-science-pathology"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:30,numberOfWosCitations:42,numberOfCrossrefCitations:23,numberOfDimensionsCitations:62,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1384",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"5861",title:"Theriogenology",subtitle:null,isOpenForSubmission:!1,hash:"b5aae519c030c5492d65c181d9c0ea57",slug:"theriogenology",bookSignature:"Rita Payan Carreira",coverURL:"https://cdn.intechopen.com/books/images_new/5861.jpg",editedByType:"Edited by",editors:[{id:"38652",title:"Dr.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita 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Heat stress decreases the secretion of luteinizing hormone and estradiol resulting in reduced length and intensity of estrus expression, increased incidence of anoestrus and silent heat in farm animals. Oocytes exposed to thermal stress lose its competence for fertilization and development into the blastocyst stage, which results in decreased fertility because of the production of poor quality oocytes and embryos. Furthermore, low progesterone secretion limits the endometrial functions, and subsequently embryo development. In addition, the increased secretion of endometrial prostaglandin F2 alpha during heat stress threatens the maintenance of pregnancy. In general, the percentage of conception rate was found to be reduced by 4.6% for each unit increase in temperature humidity index (THI) above 70, and heat stress during pregnancy further slows down the growth of the foetus and results in lower birth weight. In tropical and subtropical regions, during hot days, the testicular temperature may increase and impair both the spermatogenic cycle and semen quality, which culminates in decreased bull fertility. The effects of heat stress on livestock can be minimized via adapting suitable scientific strategies comprising physical modifications of the environment, nutritional management and genetic development of breeds that are less sensitive to heat stress. In addition, the summer infertility may be countered through advanced reproductive technologies involving hormonal treatments, timed artificial insemination and embryo transfer, which may enhance the chances for establishing pregnancy in farm animals.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Govindan Krishnan, Madiajagan Bagath, Prathap Pragna,\nMallenahally Kusha Vidya, Joy Aleena, Payyanakkal Ravindranathan\nArchana, Veerasamy Sejian and Raghavendra Bhatta",authors:[{id:"89780",title:"Dr.",name:"Veerasamy",middleName:null,surname:"Sejian",slug:"veerasamy-sejian",fullName:"Veerasamy Sejian"},{id:"177210",title:"Dr.",name:"Raghavendra",middleName:null,surname:"Bhatta",slug:"raghavendra-bhatta",fullName:"Raghavendra Bhatta"},{id:"177220",title:"Dr.",name:"M",middleName:null,surname:"Bagath",slug:"m-bagath",fullName:"M Bagath"},{id:"201967",title:"Dr.",name:"Govindan",middleName:null,surname:"Krishnan",slug:"govindan-krishnan",fullName:"Govindan Krishnan"},{id:"201968",title:"Ms.",name:"Archana",middleName:null,surname:"Pr",slug:"archana-pr",fullName:"Archana Pr"},{id:"201969",title:"Ms.",name:"Pragna",middleName:null,surname:"Prathap",slug:"pragna-prathap",fullName:"Pragna Prathap"},{id:"201970",title:"Ms.",name:"Aleena",middleName:null,surname:"Joy",slug:"aleena-joy",fullName:"Aleena Joy"},{id:"201971",title:"Dr.",name:"Vidya",middleName:null,surname:"Mk",slug:"vidya-mk",fullName:"Vidya Mk"}]},{id:"55006",doi:"10.5772/intechopen.68650",title:"Immunocastration as Alternative to Surgical Castration in Pigs",slug:"immunocastration-as-alternative-to-surgical-castration-in-pigs",totalDownloads:1876,totalCrossrefCites:9,totalDimensionsCites:19,abstract:"Surgical castration of piglets is a routine practice in pig production used to prevent the incidence of boar taint of pig meat, which may develop in entire male pigs as they reach puberty. This practice is being presently questioned in the European Union, and there is a strong initiative to end it. The initiative is presently voluntary; however, key stakeholders of European pig production sector have signed a declaration, and the actions undertaken by them already affect the business. Before such new concepts in pig production can be implemented, alternative solutions are needed, one of them being immunocastration. The present chapter will thus focus on the presentation of immunocastration as one of the promising alternatives to surgical castration. Theoretical and practical aspects of immunocastration in pig production will be described, and the advantages and disadvantages of this alternative will be summarised. Physiological principles of immunocastration and impacts on metabolism, growth performance, body composition and meat quality will be described and aspects of public acceptability reviewed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Marjeta Čandek-Potokar, Martin Škrlep and Galia Zamaratskaia",authors:[{id:"23161",title:"Dr.",name:"Marjeta",middleName:null,surname:"Čandek-Potokar",slug:"marjeta-candek-potokar",fullName:"Marjeta Čandek-Potokar"},{id:"198220",title:"Dr.",name:"Martin",middleName:null,surname:"Škrlep",slug:"martin-skrlep",fullName:"Martin Škrlep"},{id:"198221",title:"Prof.",name:"Galia",middleName:null,surname:"Zamaratskaia",slug:"galia-zamaratskaia",fullName:"Galia Zamaratskaia"}]},{id:"55696",doi:"10.5772/intechopen.69444",title:"Estrus Cycle Monitoring in Wild Mammals: Challenges and Perspectives",slug:"estrus-cycle-monitoring-in-wild-mammals-challenges-and-perspectives",totalDownloads:1852,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"The knowledge of reproductive physiology is of paramount importance to guide reproductive management and to make possible future application of assisted reproduction techniques (ARTs) aiming ex situ conservation of wild mammals. Nevertheless, information on the basic reproductive aspects of wild mammals remain scarce, and appropriate management practices have not yet been developed for all the species. This chapter discusses the methods most currently used for reproductive monitoring in wild females. Additionally, the difficulties regarding their use in different species and the possibilities of these procedures in captivity or in free-living mammals are addressed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Alexandre R. Silva, Nei Moreira, Alexsandra F. Pereira, Gislayne C.X.\nPeixoto, Keilla M. Maia, Lívia B. Campos and Alana A. Borges",authors:[{id:"90066",title:"Dr.",name:"Alexandre",middleName:"Rodrigues",surname:"Silva",slug:"alexandre-silva",fullName:"Alexandre Silva"},{id:"177090",title:"Dr.",name:"Alexsandra Fernandes",middleName:null,surname:"Pereira",slug:"alexsandra-fernandes-pereira",fullName:"Alexsandra Fernandes Pereira"},{id:"177093",title:"MSc.",name:"Gislayne Christianne Xavier",middleName:null,surname:"Peixoto",slug:"gislayne-christianne-xavier-peixoto",fullName:"Gislayne Christianne Xavier Peixoto"},{id:"198314",title:"Prof.",name:"Nei",middleName:null,surname:"Moreira",slug:"nei-moreira",fullName:"Nei Moreira"},{id:"198315",title:"MSc.",name:"Keilla Moreira",middleName:null,surname:"Maia",slug:"keilla-moreira-maia",fullName:"Keilla Moreira Maia"},{id:"198316",title:"MSc.",name:"Lívia Batista",middleName:null,surname:"Campos",slug:"livia-batista-campos",fullName:"Lívia Batista Campos"},{id:"198317",title:"MSc.",name:"Alana Azevedo",middleName:null,surname:"Borges",slug:"alana-azevedo-borges",fullName:"Alana Azevedo Borges"}]},{id:"56522",doi:"10.5772/intechopen.69549",title:"Role of Melatonin in Reproductive Seasonality in Buffaloes",slug:"role-of-melatonin-in-reproductive-seasonality-in-buffaloes",totalDownloads:1725,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Buffaloes are characterized by seasonal reproductive activity. Anestrus buffalo heifers and lactating buffaloes were used to study the effect of melatonin treatment on the resumption of ovarian activity during out-of-breeding season. Buffaloes of treated group were injected or implanted with melatonin (18 mg melatonin/50 kg body weight). Using CIDR-eCG protocol preceded with melatonin successfully achieved estrus behavior and induced conception rate during out-of-breeding season. Furthermore, the reproductive performance of buffaloes during out-of-breeding season was clearly improved by melatonin implantation in conjunction with CIDR-eCG protocol due to the luteotrophic effect of melatonin expressed as increasing diameter of CL (corpus luteum) and progesterone concentration. This improvement resulted in greater values of conception rate, in melatonin implanted compared to not implanted buffaloes. Melatonin implantation in anestrus buffalo heifers increased the diameter of largest follicles and melatonin concentration but progesterone and luteinizing hormone (LH) concentrations were decreased. In addition, melatonin implantation in anestrus lactating buffaloes increased the SOD (superoxide dismutase) enzyme activity. Sustained release of exogenous melatonin significantly protects against oxidative stress while increasing beneficial total antioxidant capacity (TAC) concentration in summer-stressed anestrus buffaloes. Melatonin implantation in conjunction with CIDR-eCG protocol successfully improved some blood metabolites, in anestrus buffalo heifers during out-of-breeding season under tropical conditions.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Tamer Awad Ramadan",authors:[{id:"197651",title:"Dr.",name:"Tamer",middleName:"Awad",surname:"Ramadan",slug:"tamer-ramadan",fullName:"Tamer Ramadan"}]},{id:"54974",doi:"10.5772/intechopen.68651",title:"Markers for Sperm Freezability and Relevance of Transcriptome Studies in Semen Cryopreservation: A Review",slug:"markers-for-sperm-freezability-and-relevance-of-transcriptome-studies-in-semen-cryopreservation-a-re",totalDownloads:1586,totalCrossrefCites:0,totalDimensionsCites:4,abstract:"Advances in sperm assessment techniques have offered new perspectives to improve the technology of semen cryopreservation. This review addresses some recent achievements in the proteomics of seminal plasma and spermatozoa and exemplifies its importance as markers for sperm fertility following cryopreservation. Recent advances in transcriptome studies on sperm RNA-Seq data have generated new information aimed to unravel the physiological roles of RNAs in the sperm-egg fertilization processes and their associations with male fertility. The relevance of the sperm freezability markers and the potential associations of RNA-profiling sequences with the sperm biological functions have been discussed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Leyland Fraser",authors:[{id:"199650",title:"Dr.",name:"Leyland",middleName:null,surname:"Fraser",slug:"leyland-fraser",fullName:"Leyland Fraser"}]}],mostDownloadedChaptersLast30Days:[{id:"55696",title:"Estrus Cycle Monitoring in Wild Mammals: Challenges and Perspectives",slug:"estrus-cycle-monitoring-in-wild-mammals-challenges-and-perspectives",totalDownloads:1852,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"The knowledge of reproductive physiology is of paramount importance to guide reproductive management and to make possible future application of assisted reproduction techniques (ARTs) aiming ex situ conservation of wild mammals. Nevertheless, information on the basic reproductive aspects of wild mammals remain scarce, and appropriate management practices have not yet been developed for all the species. This chapter discusses the methods most currently used for reproductive monitoring in wild females. Additionally, the difficulties regarding their use in different species and the possibilities of these procedures in captivity or in free-living mammals are addressed.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Alexandre R. Silva, Nei Moreira, Alexsandra F. Pereira, Gislayne C.X.\nPeixoto, Keilla M. Maia, Lívia B. Campos and Alana A. Borges",authors:[{id:"90066",title:"Dr.",name:"Alexandre",middleName:"Rodrigues",surname:"Silva",slug:"alexandre-silva",fullName:"Alexandre Silva"},{id:"177090",title:"Dr.",name:"Alexsandra Fernandes",middleName:null,surname:"Pereira",slug:"alexsandra-fernandes-pereira",fullName:"Alexsandra Fernandes Pereira"},{id:"177093",title:"MSc.",name:"Gislayne Christianne Xavier",middleName:null,surname:"Peixoto",slug:"gislayne-christianne-xavier-peixoto",fullName:"Gislayne Christianne Xavier Peixoto"},{id:"198314",title:"Prof.",name:"Nei",middleName:null,surname:"Moreira",slug:"nei-moreira",fullName:"Nei Moreira"},{id:"198315",title:"MSc.",name:"Keilla Moreira",middleName:null,surname:"Maia",slug:"keilla-moreira-maia",fullName:"Keilla Moreira Maia"},{id:"198316",title:"MSc.",name:"Lívia Batista",middleName:null,surname:"Campos",slug:"livia-batista-campos",fullName:"Lívia Batista Campos"},{id:"198317",title:"MSc.",name:"Alana Azevedo",middleName:null,surname:"Borges",slug:"alana-azevedo-borges",fullName:"Alana Azevedo Borges"}]},{id:"55491",title:"Mitigation of the Heat Stress Impact in Livestock Reproduction",slug:"mitigation-of-the-heat-stress-impact-in-livestock-reproduction",totalDownloads:4243,totalCrossrefCites:9,totalDimensionsCites:23,abstract:"Heat stress affects the fertility and reproductive livestock performance by compromising the physiology reproductive tract, through hormonal imbalance, decreased oocyte quality and poor semen quality, and decreased embryo development and survival. Heat stress decreases the secretion of luteinizing hormone and estradiol resulting in reduced length and intensity of estrus expression, increased incidence of anoestrus and silent heat in farm animals. Oocytes exposed to thermal stress lose its competence for fertilization and development into the blastocyst stage, which results in decreased fertility because of the production of poor quality oocytes and embryos. Furthermore, low progesterone secretion limits the endometrial functions, and subsequently embryo development. In addition, the increased secretion of endometrial prostaglandin F2 alpha during heat stress threatens the maintenance of pregnancy. In general, the percentage of conception rate was found to be reduced by 4.6% for each unit increase in temperature humidity index (THI) above 70, and heat stress during pregnancy further slows down the growth of the foetus and results in lower birth weight. In tropical and subtropical regions, during hot days, the testicular temperature may increase and impair both the spermatogenic cycle and semen quality, which culminates in decreased bull fertility. The effects of heat stress on livestock can be minimized via adapting suitable scientific strategies comprising physical modifications of the environment, nutritional management and genetic development of breeds that are less sensitive to heat stress. In addition, the summer infertility may be countered through advanced reproductive technologies involving hormonal treatments, timed artificial insemination and embryo transfer, which may enhance the chances for establishing pregnancy in farm animals.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Govindan Krishnan, Madiajagan Bagath, Prathap Pragna,\nMallenahally Kusha Vidya, Joy Aleena, Payyanakkal Ravindranathan\nArchana, Veerasamy Sejian and Raghavendra Bhatta",authors:[{id:"89780",title:"Dr.",name:"Veerasamy",middleName:null,surname:"Sejian",slug:"veerasamy-sejian",fullName:"Veerasamy Sejian"},{id:"177210",title:"Dr.",name:"Raghavendra",middleName:null,surname:"Bhatta",slug:"raghavendra-bhatta",fullName:"Raghavendra Bhatta"},{id:"177220",title:"Dr.",name:"M",middleName:null,surname:"Bagath",slug:"m-bagath",fullName:"M Bagath"},{id:"201967",title:"Dr.",name:"Govindan",middleName:null,surname:"Krishnan",slug:"govindan-krishnan",fullName:"Govindan Krishnan"},{id:"201968",title:"Ms.",name:"Archana",middleName:null,surname:"Pr",slug:"archana-pr",fullName:"Archana Pr"},{id:"201969",title:"Ms.",name:"Pragna",middleName:null,surname:"Prathap",slug:"pragna-prathap",fullName:"Pragna Prathap"},{id:"201970",title:"Ms.",name:"Aleena",middleName:null,surname:"Joy",slug:"aleena-joy",fullName:"Aleena Joy"},{id:"201971",title:"Dr.",name:"Vidya",middleName:null,surname:"Mk",slug:"vidya-mk",fullName:"Vidya Mk"}]},{id:"55324",title:"The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer",slug:"the-role-of-androgens-in-ovarian-follicular-development-from-fertility-to-ovarian-cancer",totalDownloads:1755,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Androgens, steroid hormones produced by follicular cells, play a crucial role in the regulation of ovarian function. They affect folliculogenesis directly through androgen receptors (ARs) or indirectly through aromatization to estrogens. Androgens are thought to be primarily involved in preantral follicle growth and prevention of follicular atresia. It also seems possible that they are involved in the activation of primordial follicles. According to the World Health Organization, endocrine-disrupting chemicals (EDCs) are substances that alter hormonal signaling. EDCs comprise a wide variety of synthetic or natural chemicals arising from anthropogenic, industrial, agricultural, and domestic sources. EDCs interfere with natural regulation of the endocrine system by either mimicking or blocking the function of endogenous hormones as well as acting directly on gene expression or through epigenetic modifications. Disruptions in ovarian processes caused by EDCs may originate adverse outcomes such as anovulation, infertility, or premature ovarian failure. In this chapter, we aim to point out a possible involvement of androgen excess or deficiency in the regulation of ovarian function. We will summarize the effects of EDCs expressing antiandrogenic or androgenic activity on female physiology. Continuous exposition to even small concentration of such compounds can initiate oncogenesis within the ovary.",book:{id:"5861",slug:"theriogenology",title:"Theriogenology",fullTitle:"Theriogenology"},signatures:"Malgorzata Duda, Kamil Wartalski, Zbigniew Tabarowski and\nGabriela Gorczyca",authors:[{id:"177042",title:"Ph.D.",name:"Malgorzata",middleName:null,surname:"Duda",slug:"malgorzata-duda",fullName:"Malgorzata Duda"},{id:"177918",title:"Dr.",name:"Zbigniew",middleName:null,surname:"Tabarowski",slug:"zbigniew-tabarowski",fullName:"Zbigniew Tabarowski"},{id:"205391",title:"MSc.",name:"Kamil",middleName:null,surname:"Wartalski",slug:"kamil-wartalski",fullName:"Kamil Wartalski"},{id:"205392",title:"MSc.",name:"Gabriela",middleName:null,surname:"Gorczyca",slug:"gabriela-gorczyca",fullName:"Gabriela Gorczyca"}]},{id:"56522",title:"Role of Melatonin in Reproductive Seasonality in Buffaloes",slug:"role-of-melatonin-in-reproductive-seasonality-in-buffaloes",totalDownloads:1726,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Buffaloes are characterized by seasonal reproductive activity. Anestrus buffalo heifers and lactating buffaloes were used to study the effect of melatonin treatment on the resumption of ovarian activity during out-of-breeding season. Buffaloes of treated group were injected or implanted with melatonin (18 mg melatonin/50 kg body weight). Using CIDR-eCG protocol preceded with melatonin successfully achieved estrus behavior and induced conception rate during out-of-breeding season. Furthermore, the reproductive performance of buffaloes during out-of-breeding season was clearly improved by melatonin implantation in conjunction with CIDR-eCG protocol due to the luteotrophic effect of melatonin expressed as increasing diameter of CL (corpus luteum) and progesterone concentration. This improvement resulted in greater values of conception rate, in melatonin implanted compared to not implanted buffaloes. Melatonin implantation in anestrus buffalo heifers increased the diameter of largest follicles and melatonin concentration but progesterone and luteinizing hormone (LH) concentrations were decreased. In addition, melatonin implantation in anestrus lactating buffaloes increased the SOD (superoxide dismutase) enzyme activity. Sustained release of exogenous melatonin significantly protects against oxidative stress while increasing beneficial total antioxidant capacity (TAC) concentration in summer-stressed anestrus buffaloes. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda",middleName:"R.",surname:"Gharieb",fullName:"Reda Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/79960",hash:"",query:{},params:{id:"79960"},fullPath:"/chapters/79960",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()