Mean level of TNF-α, IL-10, IL-6, and IL-1β in PBMC from blood of children with generalized epilepsy, incubated with 100 μg/mL of κ-CN, αS1-CN, αS2-CN, β-CN, and a mix of α-LA and β-LG obtained from bovine, caprine, and ovine milks.
\r\n\tEqually, the interlinkages that the adrenal gland has in the human body create the premises both for the description of the intimate mechanisms that induce adrenal diseases on other tissues and organs and also for strategic considerations when it comes to treatment.
\r\n\r\n\tThis book, which is aimed at both endocrinologists and practitioners in other medical fields, therefore offers an insight into the mysteries of adrenal disease and a comprehensive overview of the current state of knowledge of this gland, providing an easy-to-follow format that focuses on the most important developments in the field of etiopathogenesis, clinical and paraclinical diagnosis, and treatment of these conditions.
",isbn:"978-1-80356-687-0",printIsbn:"978-1-80356-686-3",pdfIsbn:"978-1-80356-688-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"86c26879d83ac24206ed5476b6cde7fd",bookSignature:"Dr. Diana Loreta Paun",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11853.jpg",keywords:"Cushing Syndrome, Etiopathogenesis, Diagnosis, Treatment, Minimally Invasive Technique, Adrenalectomy, Adrenal Diseases, Perioperative Management, Adrenal Cancer, Genetics, Adrenal Mass, Imaging",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",remainingDaysToSecondStep:"6 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Practitioner endocrinologist, associate professor, researcher, and manager of the National Institute of Endocrinology in Romania, coordinator of investment research and training projects, funded by European funds. Dr. Paun is a member of The Romanian Association of Clinical Endocrinology, member and president(2011-2012, 2017-2019) of The Romanian Chapter of the AACE (American Association of Clinical Endocrinologists). Dr. Păun was appointed State Advise (2015) and was appointed Presidental Advisor (2019).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"190860",title:"Dr.",name:"Diana Loreta",middleName:null,surname:"Paun",slug:"diana-loreta-paun",fullName:"Diana Loreta Paun",profilePictureURL:"https://mts.intechopen.com/storage/users/190860/images/system/190860.jpg",biography:"PĂUN DIANA LORETA, MD, PhD, FACE\r\nBorn on: February 1st, 1968 on Bucharest\r\nEmployed to: “Carol Davila”, University of Medicine and Pharmacy\r\nPosition: endocrinologist, Ph.D, Associate Professor of Endocrinology\r\nFellow of the American College of Endocrinology\r\nExperience: General Manager of “CI Parhon” Institute of Endocrinology, Bucharest, 2006-2015.\r\nMaster in Public Health\r\nQualifications in: Diabetology, Osteoporosis, Endocrine Ultrasonography, Public Health. Training in molecular biology laboratory techniques – Max-Planck-Institut für Psychiatrie, Dept. of Chemie u. Endokrinologie, München, 2002\r\nOccupational field: Clinical, Educational and Research activities, Management, Healthcare services.\r\nPostgraduate courses in: Informatics, Clinical Endocrinology, Infertility, Sexology, Public Health etc.\r\nProfessional career:\r\nChemistry-Biology High School graduated on 1986, Faculty of Medicine graduated on 1992, Th.Burghele Hospital doctor on probation during 1993–1994\r\nendocrinology resident to CI Parhon Institute of Endocrinology 1994-1998\r\nendocrinologist since 1998\r\nAssistant Professor, Lecturer, Associated Professor of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania\r\nPublications: papers presented on national and international meetings, articles publishised in well-known journals, author and coauthor in monographs and clinical guides book.\r\nParticipation on research projects and clinical trials: Director and member of the team in research projects and in clinical trials.",institutionString:"Carol Davila University of Medicine and Pharmacy",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"455410",firstName:"Dajana",lastName:"Jusic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/455410/images/20500_n.jpeg",email:"dajana.j@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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While most of them have a physical existence, the importance or significance of property is determined by the knowledge of its intended purpose.
Only when there is an idea/technology, it has been utilized as a matter in such a way that it can meet a human need/demand does it become resource. Either idea or technology becomes a resource in two ways, and they are
Material resource
Intellectual or technological resource.
Altogether the property rights are restricted or constrained by other people’s rights. Each property right is outlined and established in practice to ensure that it is balanced with other property rights.
Intellectual property is a type of property generated/created by the human minds based on their intelligence. Novelty or originality of this intellectual property diverges from one system to the others, which has a finite life span [1].
According to intellectual property, ideas are a representation of the creator’s identity or self, which need to be protected.
Different rights such as Patents, trademarks, copyrights, protection of undisclosed information, traditional knowledge, geographical indicators, industrial designs, and integrated circuits as layout designs are examples of intellectual property rights, which are recognized by the Trade Related Intellectual Property Rights Agreement (TRIPS) and governed by the World Trade Organization (WTO) (World Trading Organization).
Intellectual property rights are the rights granted to individuals over their mental inventions, and they grant an exclusive right to the inventor to utilize their product for a set length of time. This exclusive right to the inventor for their invention can encourage the technical process by
Inspire the innovation and research.
Inspire an innovator to reveal their inventions.
Offering award as a prize to help with the costs for creating new inventions.
Provides a financial incentive to invest in new lines of production that may or may not be lucrative [2].
Various Congresses in Vienna and the rest of Europe laid the groundwork for International Intellectual Property Protection in the nineteenth century. In 1883, the Paris Convention established the protection of industrial property. In this Paris Convention patents, trademarks and industrial design properties were accorded protection.
The Paris Convention established the first international trademark legislation and the concept of a well-known mark. For countries that are members of the Paris Convention, special unions and arrangements have been formed. Also in this Paris Convention, fundamental principles of Madrid agreement were outlined and represented. This Madrid Agreement is a unique agreement that was established to standardize trademarks [3, 4, 5].
Protection of literary and artistic works was framed in Berne Convention during 1886, and subsequently, International Copyright Act was passed [6].
The General Agreement on Tariffs and Trade (GATT) was negotiated on Trade and Employment Conference held in the United Nations even after negotiating governments failed to establish the International Trade Organization (ITO). The GATT was established in 1949 and lasted until 1993, when it was succeeded by the World Trade Organization, which was established in 1995 [7, 8].
The World Intellectual Property Organization (WIPO) was created in 1960, which governs both the Paris and Berne Conventions. These conventions led to establish the World Intellectual Property Organization (WIPO) in 1967 [9].
The United Nations Conference on Trade and Development (UNCTAD) was founded in 1964 to provide a venue to discuss issues concerning their economic development for developing countries. The organization’s goals are to help developing countries to maximize their trade, investment, and development prospects. In addition, the organization assists the developing countries for their efforts to integrate into the global economy fairly [10].
In 1960, global trade expanded substantially, and various National Governments realized the necessity of setting norms and rules worldwide to integrate the disparate National and regional regulations that had previously controlled. In 1966, the United Nations General Assembly established the United Nations Commission on International Trade Law (UNCITRAL) to promote the progressive harmonization and unification of international trade law [11].
World Trade Organization (WTO) was established in the year 1995 and it has become an international organization for understanding the various IPR [12].
Several corporate organizations to ensure their continued growth, higher profits, and leadership in market premeditated their project management system for
Utilization of the inter-/intra-knowledge base to its full potential.
Management of IPR on a strategic level.
Receiving knowledge and inventions as inputs from various external sources.
Managing the collaborative research by internal expertise members.
Provide mutually beneficial licenses among the knowledge ownerships.
In the future, the developing prospect will look for effective linkages between increasing societal rivalry on the one hand and establishing legal ownership of innovations on the other hand.
Knowledge, technology management, and process are incorporated in the intertwined societal, moral, and ethical challenges as the influencing approached for the several international trade.
In the upcoming decades, this technology explores new dimensions from unknown paths. This IPR will encourage for more innovation and knowledge sharing between this highly competitive networks. Various intertwined IPR are
Domain names and trademarks: In cyberspace, copyright is protected.
Traditional knowledge, prior art, material transfer agreements, and bio-prospecting rights are all protected.
Patents and software.
Biotechnological inventions.
Optional compulsory licensing, border measures, parallel imports, and IPR exhaustion
Export of technology is regulated by the government [13].
During that time, an extensive debate has been taken place about the restrictions of Intellectual Property Rights on the developing countries.
The relative intensity of their technical activity determines the potential significance of IPR in developing countries. Developing countries agreed to the TRIPS agreement for various reasons, ranging from the prospect of increased access to rich countries’ agricultural and clothing markets to the belief that stronger intellectual property rights would foster more knowledge transfer and innovation. However, in many countries, particularly in the poorest, the long-term advantages are unknown and costly to attain. But they believe that they will be having a favorable impact by enforcing the IPR. It also points out that IPRs have had variable degrees of growth effects at different eras and in different parts of the world, with countries achieving high growth rates under varying degrees of IPR protection. Stronger IPRs undoubtedly have short-term consequences for poor countries, such as higher pricing for technology and protected items [14].
Benefits of exclusive rights to innovations are
Inspiration of innovations by private organization and other enterprises.
For productive activity utilizing the new knowledge.
Spreading the new knowledge to the other organization [15].
Intellectual property rights are broadly divided into two main areas.
They are copyright and related rights and industrial property.
Copyright protects the rights of writers of literary and artistic works, which includes books, writings, paintings, musical compositions, sculpture, films, and computer programs for a minimum of 50 years after the author’s death after the work is published.
The rights of performers like actors, musicians, and singers; creators of phonograms such as sound recordings; and broadcasting companies are also protected by copyright and related rights, which is referred as neighboring rights.
The main purpose of copyright and related rights protection is to stimulate and reward the innovative creative work.
Industrial property is broadly divided into two main areas.
One area is the protection of distinctive signs, such as trademarks (which differentiate the goods, products, or services from those of others) and geographical indications (which identify a product as coming from a location where a specific characteristic of the product is essentially attributable to its geographical origin). The primary goal of trademark protection is to encourage and ensure fair competition, as well as to safeguard customers by allowing them to make educated decisions about diverse goods and services. If the symbol in question remains distinctive, the protection may extend eternally.
Other sorts of industrial property are safeguarded largely to encourage inspire innovation, design, and creation of technology development. Patented inventions, industrial designs, and trade secrets are all included in this category.
The social goal is to protect the results of investments in new technology development, thereby providing an incentive and means to fund research and development operations. Foreign direct investment, joint ventures, and licensing should all be made easier by a functioning intellectual property law. Typically, protection is granted for a set period of time (typically 20 years in the case of patents).
Intellectual property protection laws are founded on a variety of philosophical underpinnings and philosophies. In the area of tangible property, the majority of these notions are rotten. Intellectual property is fundamentally distinct from other types of property in some ways. Philosophical arguments are frequently employed to outline and define the bounds and breadth of protection in an age when intellectual regimes are being strengthened, reinterpreted, and challenged. As a result, it is critical to investigate and comprehend these arguments.
This IPR can protect the ideas and inspire the innovations, stimulating the creation of technology and innovations and design. Different types of IPR are designed, which can provide benefits by sharing the new invention as knowledge and assisting the technology transfer through licensing. Also, inspire the invention with joint venture for further development. The potential significance of IPR in developing countries is protecting their investment as incentives and inspire further development in the research, which can help to attain the desired technology advancement and economical status in this global competitive. IPR is the only key element in attaining the social, economic, and technological advancement.
The most represented animal species in terms of milk productions are cow (81.05%), buffalo (15.14%), goat (2.25%), sheep (1.20%), and camel (0.35%) that contribute differently to milk world production [1].
\nMilk represents the first food for each newborn, able to satisfy the nutritional needs differently based on yield and composition. Although the proximate composition of goat milk is quite similar to cow milk, the former has received increasing attention due to its peculiar protein, fat and mineral composition and bioactive components.
\nGreater digestibility has been attributed to goat milk due to its casein curd, which is softer and smaller and makes it more easily attached by human digestive system than that derived from other milks. Moreover, size of the fat globules and high proportion of short and medium chain fatty acids also affect the digestibility since it provides a better dispersion and a more homogenous mixture of fat.
\nAlthough the content of lactose in goat milk is comparable to that of other milking species, goat milk is rich in lactose-derived oligosaccharides (OS), especially fucosylated and sialylated OS, which are not degraded by human digestive enzymes and exert prebiotic and antimicrobial functions in the gastrointestinal tract.
\nAn appropriate nutritional intake in childhood is required for not only growth and development but also to support health and immune functions, with short and long-term implications for human well-being. Goat milk has always enjoyed particular attention for its beneficial effects in human nutrition, in particular for fragile categories such as infants and the elderly, even if the potential benefits attributed to such milk were based more on anecdotes than on scientific data.
\nTo date, scientific evidence collected in more than 70 years of scientific research and corroborated by recent advances in milk biochemistry and
The present chapter reports recent advances on the role of goat milk in several aspects of infant health. In particular, the peculiar composition of goat milk protein and lipid fractions has been deepened with the aim to exploit the use of such milk in infant nutrition.
\nThe complex genetic polymorphism of casein fraction of goat milk may offer a strategy in the treatment of cow milk allergy, due to the low amount of casein fractions in milk proteome. The study of the inflammatory response to goat milk in terms of cytokines production by peripheral blood mononuclear cells (PBMCs) stimulated with milk protein fractions represents a novel approach aiming at verifying the effective role of goat milk in the treatment of infants with cow milk allergy. PBMCs are easily isolated from blood and are used to investigate the effect of food bioactive molecules on various immune cells.
\nThe impact of milk protein mixture, casein and β-lactoglobulin fraction on cytokine production by PBMCs from infants with cow’s milk protein allergy is discussed in the present chapter. Ten patients with cow’s milk protein allergy and ten non-allergic control infants were included in the study [2].
\nThe composition of protein fraction has been investigated for its role in infant epilepsy by means of
Cytokines secreted by PBMCs are soluble polypeptides and glycoproteins that bind to specific receptors and are extremely potent at low concentrations. Their potency is partly due to the regulation of leukocyte function during inflammation.
\nThe effect of protein fractions from milk on the production of cytokines and reactive oxygen species (ROS) of PMBCs from infants with generalized epilepsy was studied.
\nLevels of TNF-α, Interleukin-10 (IL-10), IL-6 and IL-1β in culture supernatants were determined using Luminex Multiplex Assays, while the level of ROS was measured in the culture supernatants using an OxiSelect in vitro ROS/RNS assay kit.
\nThe effect of the four casein fractions and the mixture of the two main whey milk proteins from different ruminant species (cow, sheep and goat) on cytokines and oxidative phenomena in PBMCs from children with generalized epilepsy are discussed in the present chapter [4]. Separation of milk protein fractions was obtained using reversed-phase (RP)-HPLC.
\nPBMCs were obtained by density gradient from blood of 10 children with generalized epilepsy and 10 controls. Children with epilepsy were grouped according to cytokine levels as follows: one group having levels of cytokines comparable to those of the control group; a group with cytokine levels at least 5-fold higher than the control group; and a last group having cytokine levels at least 10-fold higher than those of the control subjects. The production of TNF-α, IL-10, IL-6 and IL-1β was studied in PBMC cultures, incubated with the four different casein fractions and a mixture of α-Lactalbumin and β-Lactoglobulin from dairy cows, sheeps and goats. In the cultured supernatant were also measured the levels of reactive oxygen species (ROS).
\nFinally, the present chapter gathers information on the peculiar fatty acid profile of goat milk lipid fraction and on the factors influencing the increase of fatty acids with beneficial role in human health. With this regard, the acidic profile of milk and digested milk has been studied with the aim to sustain infant nutrition in the prevention of metabolic disorders as childhood obesity.
\nThe effect of
In order to mimic milk digestion, simulated salivary fluid at pH 7, gastric fluid at pH 3, and intestinal fluid at pH 7 were prepared. Adipocytes
In-depth studies have revealed that goat milk is characterized by the presence of numerous polymorphisms in the loci of casein. The different alleles, depending on whether they are strong, weak or null, are associated with different levels of casein synthesis in milk and with different phosphorylation and glycosylation rates of the peptide chain.
\nAccording to the technological properties of milk, goat’s milk from subjects with strong alleles was associated with a greater activity of milk coagulation enzymes, resulting in a greater inclusion of nutrients in the curd, higher yields in cheese and more compact curds with respect to the milk of animals carrying weak alleles. In fact, it has been shown that homozygous goats for strong alleles (in particular CSN1S1 AA goats) are able to more effectively use food proteins and high-energy diets, resulting in the production of milk that is richer in proteins and fats [6]. The milk of animals with strong genotype also has larger fat globules and a better creaming ability than the milk of goats with null genotype [7]. Furthermore, the CSN1S1 genotype influences the concentration of some fatty acids (FA): goat’s milk homozygous for strong alleles have a higher content in short and medium chain FA (SCFA and MCFA), mainly synthesized
Goat milk offers advantages in treating people afflicted with cow milk allergies (CMA) and gastro-intestinal disorders [8]. Cow’s milk allergy is the most commonly reported childhood food allergy; recently a pan-European birth cohort study using the gold standard diagnostic procedure for food allergies confirmed challenge-proven CMA in <1% of children up to age 2 [9]. It has been reported that children affected by gastrointestinal allergy and chronic enteropathy against cow milk could be beneficially treated through goat milk therapy; although some caprine milk proteins could exert immunological cross reactivity with cow milk proteins [10]. Children with CMA present a high risk of reaching out to side reactions to other mammalian milks, so goat’s or ewe’s milk-based formulas or products may be used only after individual testing. High casein polymorphism and check for the absence of cross-reactivity could lead in future to a therapeutic approach based on personalized nutrition.
\nIn pediatric patients with CMA, IgE-binding epitopes on as1-casein, as2-casein, β-casein, κ -casein, β-lactoglobulin, BSA, IgG heavy chain, lactoferrin were recognized [11].
\nA novel approach has been conducted to study the inflammatory response to goat milk in infant with CMA by evaluating cytokines production by peripheral blood mononuclear cells (PBMCs) stimulated with whole milk, casein and β-lactoglobulin [2]. Goat milk proteins lowered the production of pro-inflammatory cytokines and enhanced the release of anti-inflammatory ones from PBMC compared to cow milk. In particular, secretion of the regulatory cytokine IL-10 after PBMC stimulation suggests that goat milk might prevent aberrant reactions towards antigens. Indeed Tiemessen [12] studied the role of IL-10 in T-cells reactivity of children affected by CMA highlighting the possibility that activated allergen-specific T-cells might concur to the formation of an active form of immune suppression
The level of synthesis of each protein fraction in milk due to genetic polymorphisms plays an important role in eliciting different degrees of allergic reaction. High frequency of the weak allele F, the presence of null allele for CSN1S1, and the high frequency of A0 genotype at CSN1S2 locus in goat breeds as Garganica goat makes this milk useful for testing on allergic subjects. Low levels of αs1-CN in goat milk means that its casein profile is closer to human milk than that of cow milk as human milk does not contain the αs1 -fraction and αs2 -fraction [13], while the major constituent is β-casein [14]. The phosphorylated serine residues of αS1 -casein, β-casein, and αS2 -casein appear to be an important allergenic epitope able to bind IgE even after a denaturing process. The αS1 -casein is characterized by linear epitopes released after protein digestion that can pass through the gastrointestinal system in immunologically active forms. The epitopes are mostly based in the primary sequence rather than in conformation. This is the reason why although extensively hydrolyzed formulas are considered the first choice for CMA treatment, these formulas have can also provoke an allergic reaction in some more allergic individuals, due to their residual allergenic epitopes [15].
\nGenetic polymorphism of goat milk proteins involved in human health and nutrition, associated with a different composition of milk proteins, may be responsible for the generation of a broad spectrum of casein-derived peptides [16]. Therefore, the study of the potential bioactivity of the peptide sequences released after hydrolysis plays a role of considerable relevance.
\nThe study of goat casein loci can lead to a differentiation of the goat population, based on the final use of milk. Animals characterized by weak or null casein alleles could be used in breeding programs aimed at producing milk with hypoallergenic properties, while animals with strong alleles could be destined to improve the quality and properties of milk and related products [3].
\nIn ruminant species, proteolytic activity in fresh raw milk can be attributed to indigenous enzymes, which originated from the animal, and to microbial (i.e. endogenous) enzymes. The major proteolytic system in milk is ascribed to the plasmin system, an alkaline serum proteinase system, and to cathepsins and elastase. Santillo et al. [17] investigated the effects of indigenous proteolytic enzymes on the release of bioactive peptides from goat milk. The authors have identified serine proteinases, and in particular plasmin, as protagonists in the release of numerous peptides deriving from β-CN and αs2-CN which could be considered bioactive molecules. The majority of the peptides showed similarity in the structure with bioactive peptides elsewhere described in goat and bovine milk and in dairy products. Some of the peptides have been shown to perform ACE inhibitory activity or have shown similarity in the structure with antihypertensive or antioxidant peptides.
\nEpilepsy includes a group of neurological disorders characterized by periodic episodes of spontaneous seizures; the World Health Organization estimates this disorder affects 0.8% of the world population [18].
\nSeveral reports hypothesize the existence of a correlation between seizures and certain foods. The role of food products of animal origin on the diet has been widely recognized, especially with regard to the effects of protein fractions. In fact, milk proteins play an important role in stimulating the innate immune response, through the activation of pro and anti-inflammatory cytokines [2]. From this perspective, the effect of goat’s milk protein fractions on the production of pro and anti-inflammatory cytokines was tested in newborn patients with epilepsy.
\nCytokines are generally synthesized and secreted in response to immunological stimuli; they are soluble glycoproteins involved in growth regulation mechanisms, in the activation of immune cells and in inflammatory and immune responses, able to reach distant cells in other organs, through the peripheral circulation [19].
\nStimulation with milk protein fractions from different milking species influenced pro and anti-inflammatory cytokines, produced ex vivo by PBMCs isolated from children with generalized epilepsy. Tumor necrosis factor-α produced by PBMCs cultured with caprine milk induced higher levels of this cytokine in 80% of infants. However, the levels of TNF-α detected in PBMC stimulated with goat’s milk reached lower levels with respect to bovine and ovine milk. Regarding the TNF-α production, casein fraction induced lower levels in a higher percentage of patients, while the whey protein fraction induced higher levels of TNF-α in 10% of children, regardless of species. Furthermore, TNF-α produced by PBMC cultured with bovine and ovine whey protein was found to be lower in 70% of patients, while TNF-α produced by PBMC cultured with goat whey protein fraction showed intermediate levels in 80% of cases.
\nBovine, caprine and ovine milk resulted in low IL-10 production by cultured PBMCs in at least 50% of cases, both for casein and whey protein fractions for all milk species studied. In general, the total amount of IL-10 detected was lower than that of other cytokines involved in this study. Interleukin-10 exerts extensive anti-inflammatory properties thanks to its inhibition of antigen-presenting cellular function and suppression of proinflammatory cytokines production [20]. Albenzio et al. [2] found higher levels of IL-10 in PBMCs cultured against cow and goat milk fractions in both healthy infants and infants affected by CMA.
\nGoat milk and casein fraction induced the highest levels of the same cytokine IL-1β in 80% of cases and whey protein induced an intermediate level in 80% of cases. Interleukin-1β is involved in promoting arousal toxicity and possibly in seizure generation [21]. There is a striking example of a dual role of cytokines on neuronal survival in diseased tissue; in particular, neuroprotective actions of IL-1β have been reported, probably mediated by its ability to induce the synthesis of astrocyte growth factors, promoting cellular repair mechanisms. The chronic expression of IL-1β during epileptogenesis suggests its involvement in the modulation of spontaneous seizures [22].
\nCaprine milk showed the highest level of IL-6 in 80% of patients, while bovine milk intermediate levels in 50% of patients, and ovine milk the lowest level in 60% of patients. The bovine and caprine casein fractions stimulated higher levels of IL-6 in 80% of cases, while sheep casein stimulated a lower level in 80% of cases. In addition to the animal species, the whey protein fraction stimulated a lower level of IL-6 in most of the patients studied. The complexity of the PBMC response against stimulation by milk protein fractions can find an answer in the bivalent nature of IL-6, which is necessary for normal nervous system development but has neurotoxic and proconvulsive effects when increased levels are detected in the brain [23].
\nSubsequently the effect of milk protein fractions (αS1-CN, αS2-CN, κ-CN, β-CN, and a mix of α-LA and β-LG) from different animal species (bovine, ovine, and caprine) was evaluated on pro- and anti-inflammatory cytokines on infant patients [4]. Evaluating the production of cytokines by PBMC after exposure with milk protein fraction is of great interest to identify potential antigens in milk. In this study the patients were grouped as: 1) children with epilepsy having low levels of cytokines not different from those of control children (LL-EC); 2) children with epilepsy having cytokine levels at least 5-fold higher (medium levels; ML-EC) than those of control children; 3) children with epilepsy having cytokine levels at least 10-fold higher (high levels; HL-EC) than those of control children.
\n\nTable 1 reports the mean levels of TNF-α, IL-10, IL-6, and IL-1β in PBMC from blood of children from HL-EC group, incubated with 100 μg/mL of κ-CN, αS1-CN, αS2-CN, β-CN, and a mix of α-LA and β-LG obtained from bovine, caprine, and ovine milks. The results of this work demonstrate how complex interleukin modulation is in response to the different protein fractions, whether casein or whey protein.
\nInterleukin | \nBovine milk | \nCaprine milk | \nOvine milk | \n
---|---|---|---|
TNF-α, pg./mL | \n284.72 ± 9.33 | \n329.78 ± 8.14 | \n336.40 ± 8.42 | \n
IL-1β, pg./mL | \n58.01 ± 1.02 | \n50.44 ± 0.92 | \n53.44 ± 1.06 | \n
IL-6, pg./mL | \n1,347.86 ± 28.81 | \n1,245.12 ± 26.89 | \n1,266.38 ± 30.01 | \n
Mean level of TNF-α, IL-10, IL-6, and IL-1β in PBMC from blood of children with generalized epilepsy, incubated with 100 μg/mL of κ-CN, αS1-CN, αS2-CN, β-CN, and a mix of α-LA and β-LG obtained from bovine, caprine, and ovine milks.
Adapted from Albenzio et al. [4].
Lower concentration of TNF-α was associated to PBMC incubated with bovine milk than with ovine or caprine milk. The major contribution to the elevation of TNF-α level was attributed to the β-casein fraction.
\nIL-1β and IL-6 recorded lower level after incubation with caprine and ovine milk than bovine milk. The differences in cytokine responses may be associated with genetic polymorphisms of the milk proteins. Concentration was lower for caprine apart from the group of patients investigated; in particular, HL-EC groups demonstrated a lower secretion in the blood stream of the interleukin. Concentrations of IL-6 were higher in cultured PBMC incubated with αS2-CN from bovine and ovine milks than in that from caprine milk. In particular, the β-CN fraction induced the highest levels of TNF-α in ovine and caprine milk, whereas the αS2- CN fraction from bovine milk stimulated the highest level of IL-6 and played a major role in production of IL-1β from cultured PBMC. In epileptic children having high cytokine levels than those of control children, the protein fraction of milk able to modulate the secretion of inflammatory interleukins appears to be represented by alpha s2 casein. Results of these recent works highlight how much the understanding of the effects of complex food matrices such as milk is still far from being completely revealed.
\nCaption to Table 1. Children have been grouped according to the level of cytokines compared to the level found in blood from control patients, as follows: LL-EC group of children with epilepsy having levels of cytokines comparable to those of control group (low level); ML-EC group of children with epilepsy with cytokine levels at least 5-fold higher (medium levels) than those of the control group; HL-EC group of children with epilepsy having cytokine levels at least 10-fold higher (high levels) than those of control group.
\nIn studies regarding childhood epilepsy, it is noteworthy to investigate the onset of oxidative stress following milk feeding, as it contributes to acute injury-induced neuronal damage [24].
\nThe evaluation of stimulation of cultured PMBC with milk and protein fractions from different species on ROS/RNS levels, evidenced that caprine milk was able to mitigate the effect on oxidative stress than bovine and ovine milks. Furthermore, within caprine milk protein fractions the ROS/RNS levels were found comparable. Lower levels of ROS/RNS detected in PBMC cultured with caprine milk fraction could be related to the lower levels of TNF-α in the corresponding fraction.
\nIt has recently been reported that the neuronal damage generated by acute injuries, resulting in detrimental effects on areas of the brain associated with learning and memory function, may be partially due to oxidative damage, which occurs during epileptogenesis [24]. Those authors also suggested that a combination therapy, based on antioxidants and antiseizure drugs, might help to reduce the cognitive impairment as comorbidities occurring in epileptic patients.
\nMilk fat derived from small ruminants represents a valuable source of fatty acids, from a nutritional and health point of view [25].
\nSmall ruminants’ milk fat presents high content in medium-chain fatty acids (C6–C10; MCFA) and five fatty acids (C10:0, C14:0, C16:0, C18:0, and C18:1), accounting for >75% of total fatty acids in caprine and ovine milk. In fact, levels of the MCFA as caproic (C6:0) (2.4%, 1.6%), caprylic (C8:0) (2.7%, 1.3%), capric (C10:0) (10.0%, 3.0%), and lauric (C12:0) (5.0%, 3.1%) are significantly higher in goat than in cow milk, respectively [26].
\nDuring digestion, MCFA are more susceptible to the action of digestive enzymes, thanks to their low molecular weight and water solubility. Gastric lipase plays a particularly important role, as it promotes faster and more complete hydrolysis than in long-chain fatty acids. Hydrolysis of MCFA releases free fatty acids which can then be absorbed without being re-esterified in intestinal cells. MCFA have been used in the treatment of some metabolic diseases; Sanz Sampelayo et al. [25] reported that some patients suffering from malabsorption problems, pancreatic insufficiency, deficiency of bile salts or subject to intestinal resection have been treated with capric and caprylic acid. Derivatives of caprylic and capric acid were emphasized as medical and nutritional specialties: MCFA were suggested as tools in the control of obesity, in lowering serum cholesterol, in infant feeding and in the treatment of childhood epilepsy. Furthermore, some studies show antimicrobial and antiviral activity for C8: 0, C10: 0 and C12: 0 [27], in particular lauric acid has been studied for its antimicrobial activity against Helicobacter pylori [28].
\nThe fat component of milk also contains essential nutrients, such as vitamins (A, D, E, K) or their precursors (carotenoids), essential polyunsaturated fatty acids and isomers of conjugated linoleic acid (CLA), which humans are not able to synthesize. CLA are a group of positional and geometric isomers of linoleic acid (cis9, cis12-C18:2, n-6). The isomer cis9, trans11-CLA, named rumenic acid, is the most prevalent—75–80% of the total CLA content in milk and meat [29]. CLA accounted for 2–4%, calculated as a percentage of total fatty acids esterified in phospholipids, in caprine and ovine milk, and less than 1% in bovine milk [30].
\nDairy products naturally contain CLA and vaccenic acid (VA) as they are produced in the rumen. The CLA content in milk is influenced by numerous factors, both endogenous (animal breed, genetic type, lactation stage and pregnancy) and exogenous (diet and environmental conditions).
\nDiet represents the factor that most influences milk CLA content, which can be naturally enriched by fresh pasture feeding [31], or through the use of specific dietary formulations including oilseeds or fish oil [32]. The content of CLA, VA and α-linolenic acid (ALA) in milk, cheese and meat are profoundly influenced by the diet of animals, which is the major source of variation. The use of pasture, fresh forage and specific vegetable fat supplements in the sheep diet greatly influences the content of these compounds in sheep products [33].
\nIn the Mediterranean area, grazing represents a fundamental dietary strategy in improving the health component of fatty acids present in sheep’s milk and meat. In fact, the meat and milk of grass-fed ruminants are characterized by a higher content of CLA, omega-3 fatty acids, beta-carotene and vitamins A and E than the meat and milk of animals fed indoors. Green herbs are particularly rich in polyunsaturated fatty acids, especially ALA, which have a positive effect on the content of C18: 3n-3, VA and CLA in milk and meat. ALA in the rumen undergoes a partial biohydrogenation at VA, in animal tissues is then partially converted into cis-9, trans-11 CLA, thanks to the intervention of Δ9-desaturase. Fish oil was used in the diet of goats resulting in a significant increase in the rate of transfer of dietary EPA and DHA into milk [34]. Recently, CLA and VA have acquired substantial importance as a consequence of the encouraging results in human studies [35].
\nBiochemical studies showed beneficial effects of the cis-9, cis-11 CLA on neoplastic and atherosclerotic processes [36, 37] as well as a cholesterol-lowering effect [35]. Epidemiological studies showed that C18:3n3 is associated with a reduced risk of cardiovascular diseases [38], whereas EPA and DHA have beneficial effects on proper brain and visual development in the fetus, and maintenance of neural and visual tissues throughout life [39].
\nIn different studies it has been shown that CLA, being an efficient ligand of PPAR alpha, is able to activate the peroxisomal beta oxidation [40] required for the synthesis of DHA starting from ALA. In addition, the peroxisomal beta oxidation is also the catabolic pathway of oxygenated eicosanoids [41], thus carrying out an anti-inflammatory activity. It follows that the diet should be rich in CLA and VA in order to increase the biosynthesis of DHA and the presence of fatty acids of the omega-3 series among highly unsaturated fatty acids (HUFA). Furthermore, CLA is metabolized in a similar way to linoleic and is able to decrease the formation and incorporation of arachidonic acid, contributing to the increase of the n-3 HUFA score.
\nAccording to data provided by the World Health Organization (WHO), the number of obese people in the world has tripled since 1975. Obesity and overweight are now recognized as real public health problems in every part of the world [42].
\nThe first cause of obesity and overweight is an energy imbalance between calories consumed and calories expended, which is mainly due to an increased intake of energy-dense foods rich in fat and to physical inactivity due to the sedentary nature of many forms of work and to the enhancement of urbanization. Overweight and obesity are strictly related to the insurgence of many other diseases affecting human health, represented by cardiovascular diseases, diabetes, musculoskeletal disorders, and some types of cancers.
\nIn recent decades, pediatric research has focused on finding a relationship between childhood obesity and infant nutrition in the first six months of life [43]. In fact, in the period between the final stages of fetal growth and the first months of the newborn life, preadipocyte cells develop in mature adipose tissue, driven by hormonal and nutritional stimuli. Childhood obesity appears to be associated with an increased risk of obesity, premature death, and disability in adulthood. Furthermore, obese children exhibit breathing difficulties, increased risk of fractures, hypertension, early markers of cardiovascular disease, insulin resistance, and psychological distress.
\nUntil recently, adipose tissue was considered only an energy reserve organ, but, following the increasing diffusion of obesity, researchers have focused attention in this field over the past twenty years [44], coming to the consideration that adipose tissue does not represent only an energy reserve, but is an important endocrine organ that has numerous targets, including some areas of the brain such as the hypothalamus. Adipose tissue is also involved in the regulation of many processes, such as homeostasis of fat mass and nutrients, regulation of the immune response, control of blood pressure, thyroid and reproductive system functions [45].
\nObesity is a metabolic disorder that manifests itself in two phenomena, namely the increase in the number of adipocytes, due to hypertrophic phenomena, and an abnormal lipid filling of already existing adipocytes, caused by hyperplastic phenomena [46]. Hyperplasia occurs mainly in the developmental age, while hypertrophy in adulthood. Obesity starts with an excessive energetic intake, due to the ingestion of fats and carbohydrates, which induces mature adipocytes to store the excess of energy as triglycerides that accumulated within the adipocytes cells, thus activating the adipogenesis with consequent growth of the cells in size and number. This cellular transformation causes a change in the adipokines secretion, the activation of pro-inflammatory processes and the increase of oxidative stress phenomena [47].
\nInfant diet is able to influence the development of adipose tissue in adults, because the transformation of preadipocyte cells into mature adipocytes takes place during the last stages of fetus growth and the first months of newborn life. Being milk the only food taken by the newborn in these phases, many researchers are interested to study the effects of milk fat component, particularly fatty acids, on the adipose tissue.
\nFlachs et al. [48] observed that some n-3 series LC-PUFAs (polyunsaturated fatty acids), as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic), can exert a metabolic action on adipose tissue to prevent obesity. Some authors have tested the effect of MUFAs (monounsaturated fatty acids) and CLAs (conjugated linoleic acid) as herbal extracts for obesity [49]. Guo et al. [50] have shown that caprylic acid and MCFA (medium chain fatty acids) have the ability to inhibit the synthesis of triglycerides by adipocytes. Other authors have also observed a relationship between fatty acid composition of diet and childhood obesity, evidencing synergistic effects among different fatty acids; in particular the association of n-6 series PUFAs with high concentrations of LA (linoleic acid) and of ALA (alpha-linolenic acid) seems to support growth of adipose tissue under nutritional
It is therefore interesting to understand the effect of the digestive process on milk fatty acids bioavailability, and whether this process may influence adipose tissue. Caprine milk was compared to human and formula milk to evaluate evaluated the effect of
The role of ROS in adipose tissue is complex. In preadipocytes the accumulation of mitochondrial ROS could inhibit cell proliferation [54], whereas in mature adipocytes from obese rats high level of ROS were observed and protection of adipocytes from oxidative stress is recognized as a potential clinical strategy in obesity treatment [55].
\nCaprilic acid has been shown to induce ROS generation and might also modulate PPARγ activity indirectly via the ROS signaling pathways [50]. Accordingly, digested milk from caprine showed a mean content of free caprilic acid higher than FM and HM (5.17 μg/ml for caprine, vs. 4.85, 3.5 μg/ml of extract for formula and human milk respectively), and this could partly explain the lower ROS content in digested human and formula. On the other hand, many natural lipid compounds with anti-inflammatory and antioxidant effects have been used to treat obesity such as n-3 PUFA, EPA and DHA, MUFA and CLA [49]. Santillo et al. [5] observed a higher content of free oleic and linoleic acid in digested human milk and infant formula; oleic acid content 1.5 and 6-folds higher and linoleic acid content 2 and 5.5-folds higher than what observed in ruminant milk, respectively. Since ROS are key signaling molecules that play an important role in the progression of inflammatory disorders [56], NF-κB p65 and HMGB1 were evaluated. HMGB1 promotes inflammation and its receptors interact with NF-κB p65 forming a positive feedback loop to sustain inflammatory conditions [57]. Among treatments, the lowest gene expression was found in HM and CM, the highest in FM.
\nGoat milk has received increasing attention due to its composition, in particular for feeding of fragile categories such as infants and the elderly.
\nGoat milk protein fraction revealed the presence of a high number of alleles at the four casein loci, associated with different levels of casein synthesis into milk. Recent research evidenced the important role of goat milk protein fraction in eliciting hypoallergenic reaction and in triggering cytokine response in cow milk allergy and infant epilepsy, respectively.
\nMoreover the exploitation of caprine milk in infant nutrition, in particular cases of pediatric metabolic disorders, should further investigate the role of the acidic profile of such milk on the mechanisms of both adipocyte differentiation and pro-inflammatory
The role of goat’s milk as a nutritional intervention useful to support clinical therapies in some emerging pediatric diseases shows promising results thus deserves further research.
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However, it can only be activated under ultraviolet light irradiation due to its wide bandgap, high recombination, and weak separation efficiency of carriers. Doping is an effective method to extend the light absorption to the visible light region. In this chapter, we will address the importance of doping, different doping modes, preparation method, and photocatalytic mechanism in TiO2 photocatalysts. Thereafter, we will concentrate on Ti3+ self‐doping, nonmetal doping, metal doping, and codoping. Examples of progress can be given for each one of these four doping modes. The influencing factors of preparation method and doping modes on photocatalytic performance (spectrum response, carrier transport, interfacial electron transfer reaction, surface active sites, etc.) are summed up. The main objective is to study the photocatalytic processes, to elucidate the mechanistic models for a better understanding the photocatalytic reactions, and to find a method of enhancing photocatalytic activities.",book:{id:"5139",slug:"semiconductor-photocatalysis-materials-mechanisms-and-applications",title:"Semiconductor Photocatalysis",fullTitle:"Semiconductor Photocatalysis - Materials, Mechanisms and Applications"},signatures:"Fei Huang, Aihua Yan and Hui Zhao",authors:[{id:"178389",title:"Dr.",name:"Fei",middleName:null,surname:"Huang",slug:"fei-huang",fullName:"Fei Huang"},{id:"185126",title:"Dr.",name:"Aihua",middleName:null,surname:"Yan",slug:"aihua-yan",fullName:"Aihua Yan"},{id:"185127",title:"Ms.",name:"Hui",middleName:null,surname:"Zhao",slug:"hui-zhao",fullName:"Hui Zhao"}]},{id:"17184",doi:"10.5772/17039",title:"Polymer Nanocomposites: From Synthesis to Applications",slug:"polymer-nanocomposites-from-synthesis-to-applications",totalDownloads:17288,totalCrossrefCites:31,totalDimensionsCites:68,abstract:null,book:{id:"1045",slug:"nanocomposites-and-polymers-with-analytical-methods",title:"Nanocomposites and Polymers with Analytical Methods",fullTitle:"Nanocomposites and Polymers with Analytical Methods"},signatures:"S. 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We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"71103",title:"Preparation of Nanoparticles",slug:"preparation-of-nanoparticles",totalDownloads:3140,totalCrossrefCites:11,totalDimensionsCites:25,abstract:"Innovative developments of science and engineering have progressed very fast toward the synthesis of nanomaterials to achieve unique properties that are not the same as the properties of the bulk materials. The particle reveals interesting properties at the dimension below 100 nm, mostly from two physical effects. The two physical effects are the quantization of electronic states apparent leading to very sensitive size-dependent effects such as optical and magnetic properties and the high surface-to-volume ratio modifies the thermal, mechanical, and chemical properties of materials. The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:71,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:75,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:124,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:10,editor:{id:"38652",title:"Dr.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. Aljaser",slug:"cryopreservation-methods-and-frontiers-in-the-art-of-freezing-life-in-animal-models",totalDownloads:163,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79782",title:"Avian Reproduction",doi:"10.5772/intechopen.101185",signatures:"Kingsley Omogiade Idahor",slug:"avian-reproduction",totalDownloads:149,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kingsley O.",surname:"Idahor"}],book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}}]},overviewPagePublishedBooks:{paginationCount:10,paginationItems:[{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Dr.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}]},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}]},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",biography:"Naceur M’HAMDI is Associate Professor at the National Agronomic Institute of Tunisia, University of Carthage. He is also Member of the Laboratory of genetic, animal and feed resource and member of Animal science Department of INAT. He graduated from Higher School of Agriculture of Mateur, University of Carthage, in 2002 and completed his masters in 2006. Dr. M’HAMDI completed his PhD thesis in Genetic welfare indicators of dairy cattle at Higher Institute of Agronomy of Chott-Meriem, University of Sousse, in 2011. 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Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},onlineFirstChapters:{paginationCount:9,paginationItems:[{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - 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