Trends of maternal deaths and MMR in the region of South Asia as per most recent stats (Year 2017) provided by the World Health Organization [1, 2].
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"6389",leadTitle:null,fullTitle:"Entrepreneurship - Trends and Challenges",title:"Entrepreneurship",subtitle:"Trends and Challenges",reviewType:"peer-reviewed",abstract:"Entrepreneurship is a powerful attitude that, in such a way, in the last few years, has become a discipline increasingly transversal to different areas of knowledge. Many times, we think about the things we want such as a good house, a brand new car, a beautiful relationship, a good friendship, and a good way to be in the world. Is that possible that you convert into an entrepreneur? This book shows some examples of that possibility, from simple people to a big organization. In all cases, if you become an entrepreneur, it will be for your taste and pleasure, a means to survive and enjoy the uncertainty, and rejoice that you have all these in your hands and will. Can you find out the trends and overcome the challenges? We would say yes. It all depends on whether you want to develop and apply this attitude.",isbn:"978-953-51-3964-5",printIsbn:"978-953-51-3963-8",pdfIsbn:"978-953-51-4092-4",doi:"10.5772/intechopen.69977",price:119,priceEur:129,priceUsd:155,slug:"entrepreneurship-trends-and-challenges",numberOfPages:170,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"f30626e6cc598d69d90838d24db873b8",bookSignature:"Sílvio Manuel Brito",publishedDate:"April 4th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6389.jpg",numberOfDownloads:12772,numberOfWosCitations:12,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:19,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:38,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 16th 2017",dateEndSecondStepPublish:"April 6th 2017",dateEndThirdStepPublish:"July 3rd 2017",dateEndFourthStepPublish:"October 1st 2017",dateEndFifthStepPublish:"November 30th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"170935",title:"Ph.D.",name:"Sílvio Manuel",middleName:"Da Rocha",surname:"Brito",slug:"silvio-manuel-brito",fullName:"Sílvio Manuel Brito",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9HrQAK/Profile_Picture_2022-04-25T07:50:04.png",biography:"Silvio Brito holds a degree in human resources management and work psychology from ISLA, a master’s degree in management in the area of organizational behavior from the Lusíada University, and a Ph.D. degree in psychology from the University of Extremadura, Spain. He is an effective member of the Portuguese Society of Psychology, INFAD (Spain), and CITUR (Portugal), as well as an investigator of Psyche EX (Spain), a member of the chair of Entrepreneurs (Spain), and the founder and general secretary of AFIDE (Spain). He teaches Human Resources at the Polytechnic Institute of Tomar (Portugal) and a master’s course in Portugal and abroad. He is also a member of its jury commissions in Portugal and abroad, and an advisor on several scientific research papers. He has published several scientific, national, and international publications in the field of human resources, management, and psychology. He is an investigator member of the Human Talent Research Group of Organizational Behaviour and Human Resources.",institutionString:null,position:null,outsideEditionCount:null,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"453",title:"Entrepreneurial Economics",slug:"entrepreneurial-economics"}],chapters:[{id:"59795",title:"Introductory Chapter: Entrepreneurship as a Trend and as a Challenge",doi:"10.5772/intechopen.75097",slug:"introductory-chapter-entrepreneurship-as-a-trend-and-as-a-challenge",totalDownloads:1266,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Sílvio Manuel da Rocha Brito Brito",downloadPdfUrl:"/chapter/pdf-download/59795",previewPdfUrl:"/chapter/pdf-preview/59795",authors:[{id:"170935",title:"Ph.D.",name:"Sílvio Manuel",surname:"Brito",slug:"silvio-manuel-brito",fullName:"Sílvio Manuel Brito"}],corrections:null},{id:"58034",title:"Arts and Entrepreneurship: Disentangling the Literature",doi:"10.5772/intechopen.72014",slug:"arts-and-entrepreneurship-disentangling-the-literature",totalDownloads:1808,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Arts entrepreneurship is not a new area of investigation, but it is far from constituting a consolidated topic. Scholars coming from several fields rediscovered it only in recent years, after a period in which it has been slow to emerge. Since the early 2000s, they developed a heterogeneous literature, which is difficult to disentangle. The purpose of this study is to shed light on arts entrepreneurship literature, outlining the most significant issues emerged and their trajectories for future development. We attempted to achieve the purpose of this chapter through a qualitative analysis of the relevant literature on the topic. Results revealed the most relevant issues to which scholars are devoting their efforts. With respect to these, we tried to identify subthemes and we attempted to trace the trajectories for future research. The first main theme concerns the entrepreneur in the arts, focusing on aspects such as identity and characteristics, and examining training and entrepreneurial education. Another theme regards entrepreneurship and training, which is attracting increasing attention, thanks also to the emergence of specific curricula and arts incubators. Besides these themes, other collateral issues emerged. Ultimately, literature is complex and multifaceted, but it is possible to read it with greater clarity.",signatures:"Francesca Rivetti and Mirella Migliaccio",downloadPdfUrl:"/chapter/pdf-download/58034",previewPdfUrl:"/chapter/pdf-preview/58034",authors:[{id:"208613",title:"Ph.D.",name:"Francesca",surname:"Rivetti",slug:"francesca-rivetti",fullName:"Francesca Rivetti"},{id:"208617",title:"Prof.",name:"Mirella",surname:"Migliaccio",slug:"mirella-migliaccio",fullName:"Mirella Migliaccio"}],corrections:null},{id:"57880",title:"Entrepreneurial Orientation and Firm Performance",doi:"10.5772/intechopen.72009",slug:"entrepreneurial-orientation-and-firm-performance",totalDownloads:1663,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"This chapter assesses the important contribution of entrepreneurial orientation’s strategic determinant that influences export performance. Based on survey data from 247 Portuguese small- and medium-sized enterprises (SMEs), findings suggest that entrepreneurial orientation has a positive and significant influence on export performance. This study deepens our understanding and provides novel insights into entrepreneurship and strategic management literature, since it combines multiple factors and has obtained the importance of each construct in SMEs business growth. Moreover, this chapter presents further evidences of the strategies that small firm managers should pursue and policy makers should promote.",signatures:"Orlando Lima Rua, Alexandra França and Rubén Fernández Ortiz",downloadPdfUrl:"/chapter/pdf-download/57880",previewPdfUrl:"/chapter/pdf-preview/57880",authors:[{id:"207969",title:"Prof.",name:"Orlando Lima",surname:"Rua",slug:"orlando-lima-rua",fullName:"Orlando Lima Rua"},{id:"215881",title:"Dr.",name:"Alexandra",surname:"França",slug:"alexandra-franca",fullName:"Alexandra França"},{id:"215882",title:"Prof.",name:"Rubén",surname:"Fernández Ortiz",slug:"ruben-fernandez-ortiz",fullName:"Rubén Fernández Ortiz"}],corrections:null},{id:"60145",title:"The Digitalisation of Rural Entrepreneurship",doi:"10.5772/intechopen.75925",slug:"the-digitalisation-of-rural-entrepreneurship",totalDownloads:1701,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:"The main primary purpose of this chapter is to present new established understanding and knowledge of the digitalization of rural entrepreneurship, how it can help entrepreneurial survival and growth in rural industries, and what are the theoretical and practical implications. The digitalization concept of businesses is the issue of interest in the world today; however, it is still of concern in the rural South African entrepreneurship sector. Collection of primary data was done from 501 owners/managers operating in rural of the KwaZulu-Natal (KZN) province. The mixed questionnaire of quantitative and qualitative was used as the survey instruments. The questionnaire was distributed at the entrepreneur’s business premises, and they were given 7 days to respond while researcher and research assistants were always available to assist where necessary. The findings of this survey revealed that the large number of participants are not using their digital technology for the business purpose, but rather they use it for other things such as private communications and social friendship. The survey was confined in one province of South Africa; therefore, the generalization of the results should be done with care. This study has indicated some recommendation and suggested further research which may include other provinces as well as other countries.",signatures:"Lawrence Mpele Lekhanya",downloadPdfUrl:"/chapter/pdf-download/60145",previewPdfUrl:"/chapter/pdf-preview/60145",authors:[{id:"208001",title:"Dr.",name:"Lawrence Mpele",surname:"Lekhanya",slug:"lawrence-mpele-lekhanya",fullName:"Lawrence Mpele Lekhanya"}],corrections:null},{id:"59850",title:"Micro-Finance: A Driver for Entrepreneurship",doi:"10.5772/intechopen.75031",slug:"micro-finance-a-driver-for-entrepreneurship",totalDownloads:1200,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Micro-finance lending has long been the answer to many rural developments around the world. It has successfully led to women empowerment and helped in enhancing the socio-economic status of women globally. Development policies and programs have often ignored women as the integral source in alleviating the growth process. The study thus examines the impact of handicrafts on the socio-economic status of women in Pakistan. It also focuses on the role played by micro-finance institutions in enabling women’s micro-entrepreneurship. Women are successfully achieving a high social and economic status in countries like Pakistan through earnings from handicrafts’ industry. The data is analyzed quantitatively, using inferential statistics to support the descriptive analysis. Results of the findings showed that handicrafts prove to be improving the socio-economic status of women in Pakistan and micro-finance has been at its backbone.",signatures:"Asma Salman",downloadPdfUrl:"/chapter/pdf-download/59850",previewPdfUrl:"/chapter/pdf-preview/59850",authors:[{id:"206443",title:"Prof.",name:"Asma",surname:"Salman",slug:"asma-salman",fullName:"Asma Salman"}],corrections:null},{id:"58202",title:"A Practical and Theoretical Approach to Social Venturing Entrepreneurship",doi:"10.5772/intechopen.72011",slug:"a-practical-and-theoretical-approach-to-social-venturing-entrepreneurship",totalDownloads:1485,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Research in social venturing entrepreneurship promoted by Professor Gert Van Dijk is gaining ground. The concept of social venturing entrepreneurship is not new. It is rooted in entrepreneurship as described by classical authors like Von Mises, Kirzner, Schumpter Knight and social reformer like Raiffeisen. It is anchored in new institutional and behavioral economics and exit strategy theory. A social venturing entrepreneur is a creator of effective social change in the context of economic, social and political conditions. Social venturing entrepreneur masters the skills of networking and lobbying. A social venturing entrepreneur is recognized by the social venturing and co-operative entrepreneurship business model they employ to execute their teleology. Social venturing entrepreneurship has advantages above conventional entrepreneurship as it has reintroduced the concept as entrepreneurship as a calling. They aim to empower the stakeholders for whom they setup the social venture and exit when the stakeholders are able to self-manage the enterprise. This chapter explains the commonly used concepts, ontologies, the social venturing entrepreneur’s social venturing and co-operative business model, the economic theories and conceptual framework and practical application from appreciative inquiry point of view.",signatures:"Moulen Siame",downloadPdfUrl:"/chapter/pdf-download/58202",previewPdfUrl:"/chapter/pdf-preview/58202",authors:[{id:"207670",title:"Mr.",name:"Moulen",surname:"Siame",slug:"moulen-siame",fullName:"Moulen Siame"},{id:"215998",title:"Prof.",name:"Gert",surname:"Van Dijk",slug:"gert-van-dijk",fullName:"Gert Van Dijk"}],corrections:null},{id:"57036",title:"From Entrepreneurial Intentions to Behaviors: Wandering In- Between and Wondering about Challenges and Avenues",doi:"10.5772/intechopen.70836",slug:"from-entrepreneurial-intentions-to-behaviors-wandering-in-between-and-wondering-about-challenges-and",totalDownloads:1171,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:1,abstract:"In order to wander and understand the chasm between intentions and actions/behaviors, this chapter presents and discusses the leading theories (such as theory of reasoned action and theory of planned behavior), alternative ones (such as implementation intention theory and theory of goal-directed behavior), potential concepts bridging the intention-behavior gap (entrepreneurial motivation and commitment) and empirical intention-based models and their applicability and predictive validity in entrepreneurship field. For that purpose, it is argued that a socio- and cognitive psychological approach is the most suitable to understand entrepreneurship and in particular the intention-behavior link. This chapter invites entrepreneurship scholars to wonder about challenges in entrepreneurship research and education field and about potential research avenues. At the end, the chapter re-launches the debate by pointing out certain questionings for future research on entrepreneurial intentions and behaviors to produce novel knowledge.",signatures:"Wassim J. Aloulou",downloadPdfUrl:"/chapter/pdf-download/57036",previewPdfUrl:"/chapter/pdf-preview/57036",authors:[{id:"207130",title:"Dr.",name:"Wassim",surname:"Aloulou",slug:"wassim-aloulou",fullName:"Wassim Aloulou"}],corrections:null},{id:"57901",title:"From Entrepreneurship to Social Activist: The Role of Indonesian Migrant Entrepreneurs in Taiwan and Socio- Economic Functions of Return-Migrant Entrepreneurship in Malang, East Java",doi:"10.5772/intechopen.72013",slug:"from-entrepreneurship-to-social-activist-the-role-of-indonesian-migrant-entrepreneurs-in-taiwan-and-",totalDownloads:1012,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In the case of Taiwan, Indonesian migrant entrepreneurs’ active in social activities; they are linked strongly to the petty conditions of co-migrants. In various cases, entrepreneurs play the role of friends in need, acting as third-party resources, to co-migrants, who turn to the former for help and self-actualization. Their activities contribute to bridging the relations between the larger community and Indonesian migrants living as a minority and as marginal foreign newcomers in Taiwan. Meanwhile, the case study of Indonesian return-migrant entrepreneurship at the home village of Malang found that migration and returning home experiences increase socio-economic mobility and develop socio-economic activities at home villages. The migrants’ experiences and enterprise activities have emerged as a critical source of sustainable livelihoods, migration knowledge of production application, self-transformation, and the economic reintegration process for return migrants in their home villages, all of which can create a new life for returnees after migration. Practically and theoretically speaking, the manner in which migrant and return-migrant entrepreneurs perform economic adaptation or social adjustment, indicates that the socio-economic function, comprising valuable ties that cut across classes, can prevent the social and economic isolation of disadvantaged entrepreneurs, co-migrants, and return migrants in the community.",signatures:"Paulus Rudolf Yuniarto",downloadPdfUrl:"/chapter/pdf-download/57901",previewPdfUrl:"/chapter/pdf-preview/57901",authors:[{id:"208588",title:"Dr.",name:"Rudolf",surname:"Yuniarto",slug:"rudolf-yuniarto",fullName:"Rudolf Yuniarto"}],corrections:null},{id:"57358",title:"Social Entrepreneurship: Case Study in Unilever Food Solutions’ Trusted Hands Food Safety Online Training Program",doi:"10.5772/intechopen.70955",slug:"social-entrepreneurship-case-study-in-unilever-food-solutions-trusted-hands-food-safety-online-train",totalDownloads:1466,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"The social entrepreneurship is important in meso (organizational) and macro (policy-making) levels. This paper focuses on a case study in Turkey. “Trusted Hands Food Safety Online Training Program” by Unilever Food Solutions is examined as an example of social entrepreneurship. It is aimed to support food safety awareness in the industry to create and certificate the chefs. Unilever Food Solutions has received the Food Security Special Award, a project developed and implemented by the Food Safety Association. In the first year, 5000 chefs in Turkey intended to complete the education of this field and to have a certificate. It started with the support of professional associations. The sustainability and private sector involvement plays an essential role in this case, which is such an important issue such as health and hygiene.",signatures:"Pınar Başar",downloadPdfUrl:"/chapter/pdf-download/57358",previewPdfUrl:"/chapter/pdf-preview/57358",authors:[{id:"208540",title:"Ph.D.",name:"Pınar",surname:"Başar",slug:"pinar-basar",fullName:"Pınar Başar"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6935",title:"Toward Super-Creativity",subtitle:"Improving Creativity in Humans, Machines, and Human - Machine Collaborations",isOpenForSubmission:!1,hash:"98c0eed8bde901e69239d5217d9be28d",slug:"toward-super-creativity-improving-creativity-in-humans-machines-and-human-machine-collaborations",bookSignature:"Sílvio Manuel Brito",coverURL:"https://cdn.intechopen.com/books/images_new/6935.jpg",editedByType:"Edited 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\r\n\tFood is the basic necessity, which sustains active and health life style. Everybody should have an access towards adequate amount of food that can be ensured through food security. Therefore, the concept regarding the food security has utmost importance for developed and developing nations. It measures that every individual has access to the food that fulfils the food safety and quality standards. Food availability, access, utilization and stability are the pillars of the food security. These pillars are being affected due to various factors such as natural disasters, poor agricultural and post-harvest practices, climate change and poor manufacturing and marketing strategies. The role of all these factors will aim to fall in the scope of this book.
\r\n\tFood insecurity results in fear of hunger and starvation that ultimately affects one’s ability to work for sustainability and economic growth of the country. In addition to this, food insecurity results in various chronic diseases due to reduce immunity that ultimately, a burned on the county economy. Therefore, this book will intend to discuss in detail about the food insecurity challenges and their effect on the quality of life. This book will also aim to provide an overview about the new trends and future prospective that help to resolve the food security issues.
As a writer of science fiction, one of us (Edwards) has written about the use of dynamically changing skin-tight garments in a future civilization. In the scenario worked out in this fictional world, the first volume of which is called Plenum [1], these membrane-like garments protect their wearers from the hardships of the vacuum of space, but they also incorporate nanotechnologies that allow surface patterns to change and swirl across the surface of the skin, or even to extrude into the third dimension.
Inspired by these ideas, and also by earlier work as a fashion designer on the part of Edwards (see collections at www.geoffreyjenedwards.com/fashion-design), a small multidisciplinary group was pulled together from different backgrounds and abilities to prototype garments that do this. Rather than using nanotechnologies, which aren’t advanced enough to permit this kind of application yet, we are working with augmented reality (AR) technologies instead. Michaud is a student with training in mathematics who has retrained in the textile arts, Proulx Guimond is a visual artist with training in 3D design and animation, and Caron-Roberge is a programmer.
Augmented reality is beginning to be used by certain avant-garde fashion designers and artistic visionaries [2]. Like many emerging technologies, the technical challenges are considerable. The field of augmented reality capabilities has progressed rapidly in the past decade, but there are still major issues that are not easily resolved to support real-time AR visualization in a robust artistic performance setting.
In this paper, we shall describe the application context, the particular choices made, and the technical challenges we overcame in order to present a real-time fashion show in front of a live audience, showcasing our designs.
Augmented reality is achieved by providing elements in a scene which can be recognized by computer vision software and tracked over time [3]. Once recognition has been obtained, the coordinates associated with the recognized image, including its orientation in space, then become the anchor point for overlaying 3D virtual reality elements in relation to this anchor point. Often AR involves careful design to ensure that the virtual elements merge seamlessly into the real elements from the observer’s perspective, so that it becomes difficult to distinguish what is real from what is virtual. That is the magic of AR, that it provides an enhanced or enriched image of the real world.
The task of creating computer vision software to do the recognition and tracking is a formidable one. Fortunately, a number of APIs now exist that do a lot of the basic work, and instead the programmer can focus more on the interface design and visual integration, which is also a challenging problem. We selected the Vuforia™ API after studying several alternatives [4]. This API is sufficiently mature to support robust work in AR. On the downside, however, it offers few possibilities for adjusting the recognition parameters. In a sense it must be treated as a black box.
In earlier work, we used artificial high contrast patterned targets, such as the one shown in Figure 1 [5]. Indeed, following numerous studies and trials in the early years of work on AR, these patterned targets had become the de facto standard for ensuring reliable recognition and tracking [3]. However, although these patterns still provide the best targets, the APIs now support non-standard targets - in fact anything that offers high contrast in an asymmetrical pattern can act as a target. Furthermore, Vuforia offers a cylindrical recognition mode. Essentially, instead of recognizing a flat target, the software will recognize a cylindrical target, which can be tracked even as it turns, thus allowing virtual elements to be added in relation to the cylinder which follow as it turns. For applications involving garments, this is ideal.
Example of our initial effort using a printed pattern target.
We use the Unity Game Engine™ as our programming or interface environment. Unity provides a stable, robust, integrative framework for immersive reality projects, and interfaces directly with Vuforia [4]. We have used it in the past for both virtual reality [6, 7] and augmented reality applications [5].
As indicated earlier, we conceived of an event that would both showcase the fashion designs and also the science fiction books which inspired the creation of these garments. As a fashion designer with several collections, Edwards had experience mounting fashion shows. We therefore conceived of an event built around the idea of a fashion show, that is, with a runway, models, and successive reveals of different garments, combined with music, an audience, and lighting ambiance. The event, however, also sought to integrate elements usually associated with a book launch, that is, excerpts to be read, copies of the book available for purchase and a book signing activity. Finally, we also undertook to develop additional representations of the event via video, and an app that could showcase some of the designs developed. These could serve both to document the work achieved and also act as marketing tools for the event and for the books that inspired the event.
Edwards selected several excerpts from Plenum that both acted as examples of the writing but also highlighted settings which could be visualized. We therefore conceived of four scenes (initially three - one was added later in the development) that would be presented. For each scene, we designed a different belt using colors and textures that matched those of the scene. Some of these original design choices were modified however, over the course of the work, as a result of changing conditions external to the work itself (and in particular, constraints imposed by the Covid19 pandemic, which struck about six months into the work).
The three initial scenes selected were (a) the approach by the main character to an artificial habitat build around a small moon or moonlet, (b) the climactic final scene which takes place in the vicinity of a sun, and (c) the large spaceborne platform called the Annex within which the main character spends most of the time. The scenes also include two kinds of ship, artificial ships and organic ships called jonahs, which are descendants of Earth-bound sperm whales. The fourth scene eventually added was to showcase the kind of dynamically shifting skin textures described in the books. For this we selected a fractal pattern.
Here are examples of the first two excerpts [1]:
Although our end goal is to create full body AR fashions, for technical reasons this is still too ambitious an undertaking. Obtaining one set of AR elements to follow the garment is already a significant challenge. So we have focused on the creation of a set of belts. One of our reasons for choosing belts is a consequence of the technology we are using, that is, the cylindrical recognition feature of the Vuforia API. However, it took considerable experimentation to work out how to do this efficiently. For example, although we earlier used patterned targets printed on paper (Figure 1), we wanted to develop fabric-based targets, but fabrics have a stitch structure that acts to effectively degrade the contrast and resolution features of the target images.
Tests with different woven fabrics were undertaken first to determine which features are best for ensuring recognition by the Vuforia software. The image used must be non-repetitive and asymmetrical as well and must favor sharp linear edges rather than curves. Experimentation showed that high contrasts are required for the Vuforia recognition and tracking software to function effectively. Furthermore, recognizable scene elements must be evenly distributed across the cylinder to ensure the belt can be tracked adequately over time and body movement. Some occlusion, for example from the arms and hands, can be tolerated without losing the tracking lock. We initially tested printed images such as the one shown in Figure 2.
Example of a printed image used to test the cylinder recognition process.
Although the Vuforia API supports a range of possible cylinders, for our application we needed a wide, relatively narrow cylinder, since it was to be worn as a belt and remain flat in its lengthwise dimension, thereby keeping its design stable. After some experiments varying the width of the belt, we found that it needed to be at least 15 cm wide to provide a reliable recognition lock. This is wider than most belts, but there are many examples in fashion where belts of that width are used. We also discovered that the Vuforia API was happier if the belt had a high contrast edge (see Figure 3).
The finished moon belt with its black edging.
Images can be pre-tested in Vuforia before they are definitively used. Essentially, Vuforia in its test mode can provide a map of recognized points (Figure 4, corresponding to a segment of the belt shown in Figure 3). Hence if the density of recognized points is too weak, the image can be further manipulated to enhance recognition, but only up to a point. Furthermore, in the case of a woven belt, such as shown in Figure 3, modification poses a challenge. Although we tested the scene recognition initially using printed images (e.g. Figure 2), the final tests had to be done with the finished weave, as the Vuforia software is sensitive to small deformations in the image. However, once the weave, itself a time- consuming step, is finished, further correction is difficult. Since some contrast is lost with the move to the woven image, we had to be creative to seek better recognition at that stage of development. We did attempt to further enhance the contrast using embroidery techniques, but ultimately the solution was of a different nature (see the discussion below concerning the background).
Recognition results for the moon belt.
Weaving complex scenes such as the image of the lunar surface shown in Figure 3 could be done accurately on a Jacquard loom. Although there are a number of Jacquard looms in Quebec City, access to them proved to be difficult (and would have been virtually impossible once the pandemic arrived). Fortunately, Michaud had completed a degree program in the textile arts and was able to use a range of different techniques to achieve similar results.
Considering the restriction of available equipment, Michaud used her own four-shaft jack table loom to test three fabric designs; overshot, shadow weave, and a double ikat-like technique (without resists). Cotton was used, as it is easy to find, does not stretch, is affordable, and can be dyed if necessary, with thread counts of 16/2, 8/2, and 8/4. Overshot in black and white, with the bigger thread 8/4, proved to be the most effective. However, the results were deemed too abstract for the project, so a compromise was made for a more pictural solution, using a double Ikat technique [8, 9], which offers a way of painting the threads before they are woven. Tests were undertaken to determine the appropriate weave density and to validate the painting techniques.
The second belt produced used an image of the solar surface (Figure 5). Recognition was generally stronger than it had been for the lunar surface (Figure 6). The belts for scenes 3 (space habitat) and 4 (fractal textures) are still under development. More details will be given below, since other parts of this work are in a more advanced stage of development.
The finished solar belt with its black edging.
Recognition results for the solar belt.
Also, in order to ensure recognition, the belts needed to be reinforced to make them stiffer. Otherwise, they would bend to conform to body shape and thereby distort the image viewed by the Vuforia software, disrupting recognition. A canvas backing was therefore added to the inside of each finished belt. The belts are 32 in. in circumference, that is, they were designed for the slender physique of most fashion models, and an elastic closure was added so that they can be adjusted to different sized waists. Experimentation has shown that the presence of a small gap in the image at the back does not appear to disrupt the recognition and tracking, nor does a small overlap.
Each of the four scenes is characterized by a different color palette. This was, of course, intentional, to give a distinct character to each scene/belt combo. The lunar scene presents yellow and orange elements, while the solar scene is more red and orange. The platform itself is gray, but the nebula is predominantly blue and green with splashes of red, purple and yellow. For the fractal scene, we decided to produce the patterns in blue and white rather than black and white. This gives its corresponding belt a distinctive color.
As illustrated in the excerpts given above, the scenes depicted are highly visual in nature. Proulx Guimond is a visual artist with whom Edwards had worked previously. Indeed, he developed the cover art for the novel, Plenum [1]. He created 3D scenes for each of the four situations. The scenes were designed so that they would integrate with the visual appearance of each belt. Hence the lunar scene was anchored to the belt which presents the surface of the moonlet itself (Figure 7), showing as extrusions of the artificial city constructed around the moonlet (in yellow). For each scene, we planned three distinct elements, first a static 2D visualization, second a static 3D visualization and finally a dynamically changing 3D visualization. The dynamic elements added to the depiction of the moonlet and its artificial extrusions were the arrival of starships which would dock with the city.
3D image constructed for the lunar scene.
In the second scene, the heliocentric orbital station is modeled (in exaggerated scale, since it would normally be too small to see at the scale of the sun) along with the surface of the solar photosphere with its sunspots. Furthermore, the dynamic elements included the jonahs and a solar flare made for a dramatic and flamboyant event within the whole sequence. To provide the fashion representation with more drama, the orbital station was situated on a diagonal with respect to the solar surface.
In the third scene, the main focus was the spaceborne platform itself, again, oriented obliquely with respect to the model’s body and extruding from this (Figure 8). The platform includes a dock and two rotating cylinders used to provide pseudo-gravity to its occupants. Here, again, jonahs are seen moving past the structure, along with an octopus who is also one of the main characters in the story. The platform is viewed against a colorful emission nebula in the background, and here the dramatic event is the swirling movement of the nebula under time acceleration, the spinning of the cylinders and the movements of the jonahs and octopus.
3D image constructed for the space platform scene.
The 3D graphics were created in 3DS Max™ and eventually transferred to the Unity environment. Efforts were undertaken to make the render of the visual as light as possible to ensure real time updating of the scene elements. This was achieved by reducing the complexity of the scene to its bare minimum, that is, incorporating only a small number of simple elements, and limiting the number of different materials and textures used. In addition, the animated sequences were also kept to a minimal complexity.
The visual integration of the virtual scene elements with the physical belt and, indeed, the body of the models required further adjustments once all the elements were in place and fully integrated. The integration, as outlined below, posed significant challenges since the majority of the work was carried out individually under lockdown conditions over the course of 2020 and the first half of 2021, that is, during the midst of the Covid19 pandemic. Indeed, at one point we considered doing the fashion show as a purely virtual event. However, the initial impetus for the project was for a show with live audience, and we remained convinced that the full impact of the AR technology consists of its use in real time in the presence of a physical audience. We therefore decided to delay the event itself until it could be performed live. As a consequence, however, this paper is being completed before the final presentation event.
Testing of our efforts to integrate the tracking software with the belts revealed a succession of challenges. We found that the software was temperamental in its ability to recognize the belt patterns, even though initial efforts had been successful. Good lighting turned out to be an important element in ensuring this recognition. Once recognition was achieved, and the virtual elements reliably overlaid on top of the optical image, it would retain the lock for a certain set of manipulations, but eventually the lock would be lost when viewing conditions became less than ideal (for example, if the person wearing the belt moved too far away from the camera). The model would then need to move in close, or image viewing parameters otherwise manipulated, until a recognition lock could once more be obtained. At first, the virtual image was stable only for short intervals. We introduced some persistence into the visualization, so that even when the recognition failed, the virtual objects would persist a second or so. This sometimes results, however, in a jerky movement of the virtual elements in relation to the model’s movement.
Effective integration also required introducing occlusion effects. Hence, we used the belt’s cylindrical shape to create an occlusion model and used this to hide virtual elements as they ostensibly moved behind the body. Without intentionally occluding the virtual elements in this way, they were perceived as always being in front of the model, breaking the illusion.
As the model moved, the location of the virtual elements would often lag behind the model. We used a cube-like envelope to test these issues. We eventually discovered that we had been testing the performance of the visualization against “busy” backgrounds. Much of the early testing was done in a living room or kitchen viewed on Zoom. When we met and did tests outside, the same problems persisted until we chose a uniform background. At that point, many of the tracking problems diminished. After that, we chose uniform walls for testing. Feature-filled backgrounds clearly confused the recognition software, causing it to lose its lock more frequently. Once this problem was identified, lock persistence, although not perfect, became acceptable.
At one point we also sought to use an accelerometer and Inertial Motion Unit (IMU) that could be integrated into the garment as another source of data to help stabilize the imaging. Our efforts in this direction failed to generate the necessary stability, however, and the effort was abandoned.
Another strategy we eventually developed to ensure longer lock persistence was to restructure the viewing geometry using a second camera feed. Essentially, we had been using the same camera image as the source for recognition and to serve as the support for the visualization. Our realization that Vuforia must degrade the image somewhat during processing, a realization that followed its lack of sensitivity to difference resolution webcams, led us to segment out of the image the region surrounding the belt and provide this image segment to Vuforia in a separate camera feed instead of the full image (Figure 9). This resulted in better recognition at a wider range of distances. Hence, for example, in our earlier attempts a distance of about a meter was required to ensure a recognition lock, but after the segmentation step was added, a reliable lock up to three meters could now be achieved.
Image of the finished lunar belt in situ along with image subset used for recognition.
Recourse to a more complex set of processing options such as described here meant, however, abandoning our commitment to permitting the use of a tablet or smartphone for viewing the AR scene. In the final configuration, we need access to a full computer, although a laptop is also acceptable.
Each belt is used to anchor its corresponding scene—indeed, each scene was designed so as to align the final appearance including the moving model with the esthetics of the 3D images. In principle, this means that several belts and animations could be viewed simultaneously. In practice, however, since each set of animations requires significant computing power to render in real time, we preferred to keep each presentation separate. Furthermore, the belts are worn with a white top to provide a canvas over which the 3D visuals can be overlaid.
The final integration of the 3D graphics with the physical belts are shown in Figure 10 for the lunar belt and Figure 11 for the solar belt. As indicated earlier, two additional scenes are under development, one involving a large space platform and the other a dynamically changing costume incorporating fractals. The 3D images are almost complete and the belt development is in its final stages. With the relaxation of lockdown restrictions currently underway, the organization of the event itself is also now possible.
3D image for the lunar scene integrated with the physical belt in situ.
3D image for the solar scene integrated with the physical belt in situ.
A staging scenario was developed for the presentation in front of a live audience. This script included information on the timing of each segment. This was necessary also to assist in the development of the music accompaniment. At this point in the development of the event, the music has still not yet been finalized. However, we are proceeding as we have in previous projects, which is to mash together public domain samples of music into a coherent and dynamically interesting whole [6].
The total duration of the final show is estimated to be about 40 minutes. Following an introduction, the presentation of each of the four belts cycles through the three levels of visualization (static 2D, static 3D and dynamic 3D), along with the reading of the text excerpt, and hence each belt takes about ten minutes to present. After the individual belts are presented each in turn, the four belts are presented together in a kind of finale, without the full dynamics so as to render the processing tractable and with an additional excerpt. Following the conclusion, a book signing session is expected to be announced.
Our plan is also to stream the event for virtual participants. Indeed, the book publisher is located in Boulder, Colorado, and both collaborators and other interested parties are located there. Streaming became a de facto standard with the pandemic, and we retain that here. In addition, we are developing an app which will allow the 3d scenes to be viewed independently of the belts, as a value-added product to be made available to individuals as part of the marketing of the book.
In summary, our Plenum A La Mode event constitutes a unique amalgam of different ideas and technologies that straddles the artistic, scientific and technological worlds. The technical challenges in terms of obtaining reliable recognition of the fabric belt patterns, tracking the belt over a complex set of manipulations and movements in real time, and visually integrating both the optical scene with virtual three-dimensional enhancements were considerable. Furthermore, the project required the close collaboration of several individuals with different areas of expertise to achieve the desired results, including the writer, event and fashion designer (Edwards), 3D graphics artist (Proulx Guimond), textile artist (Michaud) and programmer (Caron Roberge). Another colleague with expertise in the development of music is also working with us, Jocelyne Kiss.
Among the challenges addressed and overcome were the introduction of occlusions using the belt cylinder as a model, so as to create the illusion of virtual elements passing behind the model’s body, the provision of stable and good lighting conditions to ensure robust target recognition, the use of uniform backgrounds so as to limit confusion for the recognition software, the use of a second camera feed so that the tracking could be carried out independently of the scene enhancement, and the introduction of persistence to enhance the stability of the visualization of the virtual elements and prevent loss of the recognition lock.
The final result of these efforts provides acceptable, but not perfect, real time augmented reality image enhancements. The virtual elements experience a small amount of jitter while the software tries to track the belt, and if the movement is too rapid, the model passes behind a visual obstacle, or simply moves too far from the camera, the recognition lock is lost and the virtual elements disappear until a new lock is acquired (generally by moving towards the camera and holding still). The public staging requires the use of a desktop computer of relatively strong power, loud-speakers and a webcam. Our expectation is to project the enhanced image onto a screen as the model parades along the runway. The belts are themselves esthetically interesting as well as serving as target patterns for the augmentation.
Ultimately, we believe that more complete full body augmentations could be achieved using several targets integrated into the garment design. These might include flat targets in some areas, such as across the chest or back, as well as additional cylindrical targets for, example, around the thighs and arms. The augmented images would need to be matched to each other and integrated visually into a seamless whole, which will pose many additional technical challenges to the ones we encountered. Details of the final fashion show event will be made available through the principal author’s website at www.geoffreyjenedwards.com.
The maternal mortality rate is highest for Asia and it is even higher for South Asian countries including Pakistan. As per most recent stats around 295,000 women die during and following childbirth worldwide in a year. South Asia alone accounts for almost 1/5th of all these deaths (Figure 1 and Table 1). It is regrettable to note that about 94% of maternal deaths occur in underdeveloped countries [3]. A most recent survey naming ‘Pakistan Maternal Mortality Survey 2019’ conducted by the National Institute of Population Studies funded by USAID shows considerable demographic variations in maternal mortality rates of women residing in rural and urban areas of Pakistan. The maternal mortality ratio in Pakistan is 186 deaths per 100,000 live births. The ratio is nearly 26% higher in rural areas as compared to urban areas [4]. In order to avoid complications, it is imperative to provide mothers with skilled care and safety during pregnancy, childbirth, and the postnatal period. There are various contributing factors including poverty, lack of education, gender-based inequalities, inadequate and poor quality of healthcare services, distant facilities, sociocultural values, malnutrition and violence against women, unfair distribution of resources, and political environment; can be termed as key indicators for increased maternal death burden in rural areas. Moreover, having the Millennium Development Goals (MDGs) failed, now Pakistan is lagging far behind in achieving Sustainable Development Goals (SDGs). Domains of unmet SDGs include a reduction in child death, improvement in maternal health, and a greater number of births by skilled personnel [5]. This chapter concentrates on challenges to maternal health in rural areas alongside options and interventions to deal with these challenges.
The number of maternal deaths in the region of South Asia. Stats by the World Health Organization on maternal mortality trends 2000–2017 estimates that South Asia accounts for 57,000 maternal deaths.
Sr. No | Country | Number of maternal deaths | Percentage of maternal deaths | Maternal Mortality Ratio (per 100 K live births) |
---|---|---|---|---|
1. | India | 35,000 | 61.03% | 145 |
2. | Pakistan | 8,300 | 14.47% | 140 |
3. | Afghanistan | 7,700 | 13.43% | 638 |
4. | Bangladesh | 5,100 | 8.89% | 173 |
5. | Nepal | 1,100 | 1.92% | 186 |
6. | Sri Lanka | 120 | 0.21% | 36 |
7. | Bhutan | 24 | 0.04% | 183 |
8. | Maldives | 4 | 0.01% | 53 |
The maternal mortality ratio (MMR) is defined as the number of maternal deaths in a certain time duration of 100,000 live births. It is an indicator of the possibility of maternal death with relevance to the number of live births. It is a measure of the risk of maternal death as per pregnancy or one live birth [6, 7].
It is the total number of annual women death expressed per 100,000 live births because of complications during pregnancy and childbirth or inside the time of 42 days following the end of pregnancy, regardless of the length and site of pregnancy, in a specified period. It is important to note that it does not include the incidental or accidental occurrence of maternal deaths [6].
It is defined as the removal or extraction of the whole conceived product from the mother, regardless of the period of pregnancy, which after the expulsion shows any sign of life such as breathing, a beating heart, pulsating umbilical cord, moving voluntary muscles (irrespective of the fact that the placenta has been detached or not) [6].
The maternal mortality rate can be defined as the number of mothers who die per 1000 women [8].
Below is given the formula (Eq. 1) to calculate the maternal mortality rate in a specific geographical area [9].
The pregnancy-related mortality ratio (PRMR) is defined as the number of pregnancy-related deaths per 100,000 live births [10].
Pakistan ranks fifth in the world according to population. Pakistan is an agriculture-based economy and recent stats show that 64% of the Pakistani population lives in rural areas [11]. According to the most recent report on the nationwide maternal mortality survey in Pakistan, MMR is 186. The report also indicates a considerably increased incidence of maternal deaths in the rural areas of Pakistan. MMR for urban areas of Pakistan is 158 while on the other hand MMR for rural areas is 199 which shows there a difference of 41 deaths per 100,000 live births [4].
With a majority of the population living in the rural areas, there is a major difference in health care services provided to the people living in urban areas as compared to those living in distant regions. Here are some of the contributing factors in poor health conditions of women during the prenatal and postnatal era which subsequently result in elevated levels of maternal deaths in rural areas.
Pakistani women, especially those belonging to rural Pakistan are lacking in education which in turn serves as a stimulus for increasing maternal mortality ratio. According to recent surveys, 62% of the rural women population of reproductive age is uneducated which is way more than the uneducated percentage of the urban women population. A 34% women population of childbearing age living in urban areas has no education. While in urban Pakistan the percentage of women of reproductive age, possessing secondary or higher education is 39%. Only 14% of the rural women population have secondary or higher education. In Sindh and Balochistan, 4 in every 5 women are uneducated. When compared to the urban Sindh population, 2 in every 5 women have an education of secondary or higher levels. It has been estimated that around 63% of the maternal deaths account for those women who had no education (Table 2 and Figure 2) [4].
Attributes | Women with no education | Provincial distribution of uneducated women | |
---|---|---|---|
Residence | Rural | Urban | |
Level of schooling | 62.3% | 33.6% | Total uneducated = 51.7% |
Punjab | 50.5% | 27.2% | 41.7% |
Sindh | 82.4% | 36.5% | 57.1% |
Khyber Pakhtunkhwa | 70.0% | 48.5% | 66.8% |
Balochistan | 80.4% | 66.5% | 76.2% |
A comparison of ever-married women between the ages of 15 to 49 having no education in rural and urban areas of Pakistan according to Pakistan Maternal Mortality Survey 2019 [4].
Percentage distribution of educational attainment of deceased women who died three years before the Pakistan Maternal Mortality survey 2019 (Ages 15-49 yrs). Primary level education: Class 1–5, Middle-level education: Class 6–8, Secondary level education: Class 9–10, Higher level education: Class 11 and above.
It is pertinent to mention here that Article 25A of the constitution of Pakistan states that the onus is on the state to provide free and compulsory education to individuals between the ages of 5–16. Article 25 also enables the state to make any special provisions to ensure women’s protection and the children thereon [12]. School dropout rate because of distant educational centers, inadequate safety measures such as missing boundary walls in schools, gender-based inequalities, and poverty are the main causes of vast differences in the educational attainment of the women living in urban and rural areas. The spirit of article 25 of the constitution of Pakistan is to empower every individual irrespective of gender and regardless of the area where one lives. Women who have no education at all have higher maternal mortality, malnutrition, children with stunted growth, and infant mortality rates. The disparities in educational infrastructure which the women face in rural areas are holding back them to showcase their full potential in all domains of life. There is a famous Chinese proverb, “If you are planning for a year, sow rice; if you are planning for a decade, plant trees; if you are planning for a lifetime, educate people.”
Women’s reproductive behaviors are largely influenced by gender-based inequalities, by depriving them of their basic rights and self-sufficiency [13]. Pakistan ranks at number 151 out of 153 countries in Global Gender Gap Index which depicts Pakistan’s bad standing in the global gender equality scenario [14]. It is a grim situation where almost 48% of the country’s total population doesn’t have equal opportunities in educational achievement, political participation, economic opportunities, and survival and health. A large chunk of the female population is deprived of basic healthcare facilities in rural areas of Pakistan. 69% of the total maternal mortalities occurring in Pakistan belong to women living in rural areas. When it comes to maternal health, the majority of the women don’t have decisive powers even to seek healthcare facilities for themselves. Women’s reproductive health, as well as maternal mortality rates, are largely dictated by their decision-making powers for their health [15]. Gender disparities directly predispose women to malnutrition, violence, delay in seeking healthcare, neglect, and ill-treatment during pregnancy, child marriages, and uncalled-for maternal mortality and morbidity. Some of the issues are explained in detail below.
Violence against women especially spousal violence has a negative impact not only on maternal health but also on antenatal care [13]. Vulnerability to all forms of violence—psychological, emotional, physical, verbal, and sexual—of rural women increases manifolds as they have no education, lack of skills and awareness to guard themselves. In many instances, domestic abuse is used to control and overpower women in rural areas. According to studies, spousal violence aggravates the risks associated with bad maternal health conditions. Women experiencing violence are likely to have more chances of pregnancy termination or lost pregnancies. In addition, in areas where healthcare facilities are already scarce, spousal violence contributes to decreasing the probability of maternal healthcare visits for antenatal care. In low-income countries like Pakistan, one in every ten women is subjected to spousal violence during the gestation period. Data shows that 24% of women experience less severe physical violence while 7.6% women population experience violence during pregnancy [16]. Women are more prone to domestic abuse in the case of female fetuses and in worst cases are even beaten to death [13]. This terrible reality further raises concerns for gender equality and equitable opportunities for maternal healthcare for women residing in remote areas.
Rural women are victims of honor killing and similar crimes such as nose-cutting, acid attacks, burning, imprisonment, and forced or child marriages [17]. In a society with deeply ingrained social norms including killing girls in the name of honor and forcing them into early marriages result in exacerbation of the impacts of gender disparities. Pieces of evidence of child marriages remain high in the female population with no or low education residing in rural parts of the country. Women with early marriages i.e. before the legal age of marriage as per law are unlikely to utilize maternal health care services via trained medical staff. Hence they are more likely to have their children delivered at homes which are associated with the increased maternal mortality and morbidity rate. No denying the fact, high MMR correlates with early or child marriages which is essentially not as greater a concern for the neighboring countries like India, Bangladesh, and Nepal as it remains for Pakistan [18]. The majority of the women in Pakistan, let alone those living in the rural parts of the country, are generally vulnerable to old customs, and outdated cultural traditions which sometimes cost their lives.
Poor health conditions of women in Pakistan especially those living in rural areas are essentially attributed to socioeconomic factors [8]. Pakistan is a developing economy with a population of 210million people, and the rural population is more prone to poverty and impoverishment. Recent trends show that 1/4th of the total population lives below the poverty line. With a majority of the people living in rural areas, 31% of the rural population is impoverished in comparison to 13% urban population [19]. A vast difference in the economic factors of rural and urban populations increases the reproductive health-related concerns in rural women. They are more vulnerable to undernourishment and their kids are more likely to be malnourished. Furthermore, poverty is a predisposing factor in seeking healthcare facilities before, during, or after pregnancy (Table 3). Women in impoverished households usually have higher fertility rates, more incidence of undergoing unsafe or traditional delivery practices performed by unskilled persons, and less evidence of following a family planning regimen. All these factors negatively impact the reproductive health of rural women and in turn, increases MMR for Pakistan.
Economic status | Percentage of deceased women | Women with no education | Percentage of women seeking for treatment of pregnancy-related complications |
---|---|---|---|
Lowest wealth quintile | 21.0% | 91.2% | 44% |
Second wealth quintile | 21.6% | 73.8% | 52% |
Middle wealth quintile | 21.4% | 57.1% | 52% |
Fourth wealth quintile | 18.4% | 32.0% | 56% |
Highest wealth quintile | 17.6% | 13.7% | 55% |
Association of maternal mortality with economic conditions, educational attainment, and treatment-seeking behavior according to Pakistan Maternal Mortality Survey 2019.
As per population, Pakistan ranks in 5th place in the world. Since the very first population census held in 1951, the population of the country has grown by more than 6-folds [20, 21]. Census is meant for the purpose to access and gather data about the individuals living in a country which enables the policy-developers to make policies and plan programs accordingly. Census is prescribed to be held in the country every ten years. Unfortunately, except for the second and the fourth census, none has been held according to the prescribed schedule. After 1951, the second census in Pakistan was carried out 1961. The third census was due in 1971, but it was held in 1972. The fifth census was to be organized in 1991, but it was conducted in 1998. And the most recent census in Pakistan has been arranged in 2017 [22]. Reasons for the delayed census are primarily political instability in the country. Pakistan has three times faced decade-long military rules. To date, none of the elected Prime Ministers in the country has ever completed a 5-years term. Additionally, the country has fought three major wars with India. Overcoming longs delay in census is a necessary element to curtail discrepancies in the health care infrastructure. Rural areas in Pakistan are deprived of necessary and essential healthcare facilities and so does the women living there. Many rural mothers die on their way to distant hospitals situated in cities. There is a dire need to ensure political stability and making long-term policies for the development of healthcare infrastructure in all areas of Pakistan. After all, health is wealth!
Since the day of inception, Pakistan has made very little progress towards improving key indicators of maternal health. Pakistan has been a signatory to many international conventions regarding improvement in maternal health and decreasing MMR. Despite various programs and efforts, the implementation regimen remains poor. Many disparities are prevailing between the rural and urban population and access to maternal healthcare services is one of them. Elevated levels of MMR in rural Pakistan are directly linked to a variety of factors such as compromised status of women in society, undernutrition, high-risk pregnancies, poor or delayed access to health care facilities, illiteracy, and poverty. Here are some options and interventions which are essential to improve maternal health in rural areas of Pakistan.
Women empowerment and gender equality contribute to a great extent in making women able to understand their own needs, a value in the family system, and a broader perspective in society as a whole. They can ask for their rights to access quality health care services and can better take care of themselves as well as their newborns. Moreover, to prevent maternal deaths and improving the wellbeing of rural mothers, this knowledge plays a fundamental role. Gender equality allows women to avail the lifesaving opportunities, taking all benefits from the public policies and programs which in turn uplifts the condition of maternal and neonatal health. Besides, equal participation of women in the healthcare workforce of rural areas is also crucial to curtailing MMR.
Pakistan has long remained hard on women and nonetheless, the situation is the same. Studies have shown that pregnant women living in rural areas of Pakistan are more victims of deprived mental health as compared to those of urban women [23]. The economic status of women, social relations and social conditions, and pregnancy-related concerns are major determinants of maternal mental health. Women in rural areas are more prone to subjugated roles, old customs and traditions, Watta Satta (exchange marriage of women from two families), and inheritance issues are some of the predominant causes of the depressed mental state of pregnant women in rural areas of Pakistan. Studies have suggested that depression is twice more common in rural mothers in comparison with urban pregnant women. On top of that, discussing or treating mental health issues is taken for granted in Pakistani society. A depressive mental state can have severe negative implications for the mother’s health and the health of the kid and family associated with her [23]. Hence, investment in addressing social determinants of maternal health of rural women is of prime importance to reduce MMR and move a step forward in achieving SDGs.
Women consist of almost half of Pakistan’s population [24]. For one, their participation is all the more important in the development and the progress of society. Countries, where women are empowered and getting equal opportunities, are quoted as instances of progress and prosperity. On the contrary, in Pakistan women, health care workers get targeted for the polio vaccine immunization program. This further poses a hindrance to the recruitment of women health care staff in high-risk rural districts. Consequently, the MMR for Pakistan especially in rural regions remains high.
Following are some key factors recommended by WHO to achieve essential goals to save women lives and to decrease maternal mortality by means for empowering women [25].
Reduction of the routine burden of physical labor on women in rural areas
Improving gender equality in relationships
Investing in the health-related literacy in women, and the overall community
Increasing and understanding the value of a girl-child and decreasing son preference
Abolishing harmful conventional norms and practices surrounding gestation and the postpartum period.
Eliminating child marriages
All aforementioned factors are equally necessary to improve maternal health and reduce the lifelong risk of maternal death and disability in rural Pakistan.
Abraham Lincoln has said, “Democracy is the government of the people, for the people and by the people.” Pakistan is a country with constitutional democracy. Respecting the constitution and understanding the letter and spirit of laws is indispensable for every citizen of the country. Where democracy goes from strength to strength, people are empowered. It also ensures the continuity of public programs and policies in the long run. Furthermore, the onus is on the policymakers to prioritize the health sector by allocating more budget to the health sector.
The recent ranking of Pakistan in the Open Budget Index 2019 is 93 out of 117 countries. Whereas the budget transparency score for Pakistan is 28 out of 100, which is way below the other South Asian countries. Budget transparency is an estimate of access of information of the general populace to the information about the central government’s expenditure of public resources. It also estimates the involvement of the public in national budgetary concerns. Afghanistan, India, Nepal, Sri Lanka, and Bangladesh are ranking at better positions in comparison to Pakistan [26]. In 2017 Pakistan’s expenditure on healthcare per capita was $42 and in 2018 it was $43 [27]. Pakistan is not at par with the developed economies in providing health security to all the citizens. Those living in distant areas are more affected by this grim reality. Rural women are reportedly seen to pay fewer maternal visits to the healthcare settings during and after pregnancy in contrast to urban women. Culturally and socially bound women living in rural areas need better healthcare facilities for themselves and their children. By taking into consideration suggestions from all the prominent stakeholders while planning and policymaking, creating long-term health-associated policies, and prioritizing a health-sensitive budget are vital factors to reduce MMR, improve human rights status, and obtaining success in Agenda 2030 (SDGs).
A tremendous chance to learn how to reduce maternal mortality is knowing about the interventions and decisions from the exemplars who have achieved fairly low maternal mortality. A comparison of maternal mortality data of 1990 and 2013 (Table 4) shows that through the successful interventions—Bangladesh, China, Cambodia, Egypt, Nepal, Peru, Vietnam, Rwanda, and Lao PDR—have reduced almost 70,000 maternal deaths at a substantially faster pace [28]. Despite the enormous and individual political, social, and economic challenges; understanding that how these countries have got success in reducing child death and maternal mortality rates will be of great help to learn about the strategies, policies, and areas of investment and achieving desired outcomes in no time.
Sr. no | Countries | Reduction in Maternal mortality | Reduction in <5 child mortality | Successful interventions made by fast track countries |
---|---|---|---|---|
1 | Bangladesh | 66% | 65% | Successful coverage of vital interventions (family planning, immunization, oral rehydration treatment in rural areas) Public-private partnership Gender equity Access to education for women Access to the latest information and communication technology Improving road networks |
2 | Cambodia | 75% | 57% | Timely access to immunization Developments in socioeconomic conditions Timely breastfeeding |
3 | China | 80% (approximately) | 80% | Successful coverage of vital interventions Strengthening healthcare workforce Access to water Access to sanitation |
4 | Egypt | 69% | 75% | Family planning Immunization Improving literacy rate Improving water access Improving access to sanitation facilities |
5 | Lao PDR | 6.8% | 56% | Strengthening coverage of vital immunization Preventing malaria Family planning Timely and exclusive lactation Improvements in socioeconomic status |
6 | Nepal | 80% | 66% | Increasing number of skilled birth attendance Integrating and prioritizing health in politics Improving education Improvements in transportation and communication Access to water and sanitization |
7 | Peru | 65% | 70% | Social progress Political will and stability Economic growth Addressing cultural barriers Increasing access to health care facilities by minimizing geographical barriers |
8 | Rwanda | 22% | 50% | Increasing healthcare workforce Improvements in healthcare infrastructure Improving access to healthcare centers Increasing access to education Prioritizing women political and economic involvement Addressing issues of malnutrition in women |
9 | Viet Nam | 70% | 60% | Prioritizing timely immunization Nutrition and child-survival regimes Skilled birth attendance Availability of contraceptives Access to clean drinking water Access to sanitation Increasing primary school enrollments |
Successful interventions made by fast-track countries in curtailing maternal mortality rate and improving child health and survival rate. Data in the table shows a comparison of rapid reduction in maternal mortality and child mortality between 1990 and 2013 [28].
To reduce maternal mortality and morbidity in the rural Pakistan, there is a need to focus on the following aspects:
Increasing allocation of budget and funding in the health sector to the provinces (as per their needs) in NFC award (National Finance Commission) by a re-evaluation of healthcare infrastructure.
A collaboration of the center and provinces in integrating health with the economic progress and promoting the judicious distribution of resources.
Prioritizing women’s reproductive health and investing more in maternal and child healthcare programs especially in rural areas of Pakistan.
Expanding the quality and quantity of primary healthcare services for maternal, neonatal, and child health care in remote and rural districts.
Introducing family planning programs and educating women and the community about the nutritional needs for maternal and neonatal care.
Spending in awareness campaigns and education of women to address social determinants of maternal mortality and morbidity in the remote areas.
Investing to strengthen the district healthcare information system, routine monitoring, accountability, and regular-evaluation of performance at district level health care centers and hospitals.
Investing in reachable, affordable, and quality education for women living in remote areas of Pakistan.
Maternal health is not only linked to a woman but also her kids and the family. Healthy mothers are a prerequisite for healthy children. And children are an asset for a country’s future human capital. Mothers are directly involved in improving the nutritional outcome of this human capital. Women in Pakistan are dying because of many complications that are either avoidable or treatable. By bridging the gaps of gender-based inequalities, providing equal opportunities to all women in rural areas, social reforms, prioritizing a health-sensitive budget, promoting women education, long term policy development, and planning programs to improve maternal and child health, investing in bringing down disparities between urban and remote areas, health care system interventions at the district level, not only can help Pakistan in achieving the SDGs 2030 but also help in ranking the country higher in human development index. Whether these are rural or urban areas, at every level, all-inclusive regimens are required to achieve global goals to reduce the maternal death burden. As we grow, we grow up collectively!
Authors are very much thankful to Higher Education Commission (HEC) Pakistan for providing the financial assistance under the NRPU research project.
All the authors have no conflict of interest.
Authors are very much thankful to you for the Dean faculty of Pharmacy, Prof. Dr. Muhammad Uzair, Chairman department of Pharmaceutics, Prof. Dr. Syed Nisar Hussain Shah, Associate professor department of statistics Dr. Muhammad Ahmad shahzad for providing the research facilities and survey based data.
Sustainable Development Goals United States Agency for International Development Millennium Development Goals Maternal mortality ratio Pregnancy-related mortality ratio World Health Organization National Finance Commission
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We will also focus on recent breakthroughs of the MAPLE technique for the fabrication of functional devices, i.e. sensor devices based either on chemoresponsive polymers or on proteins.",book:{id:"6059",slug:"laser-ablation-from-fundamentals-to-applications",title:"Laser Ablation",fullTitle:"Laser Ablation - From Fundamentals to Applications"},signatures:"Alexandra Palla Papavlu, Valentina Dinca, Mihaela Filipescu and\nMaria Dinescu",authors:[{id:"32241",title:"Dr.",name:"Maria",middleName:null,surname:"Dinescu",slug:"maria-dinescu",fullName:"Maria Dinescu"},{id:"176781",title:"Dr.",name:"Valentina",middleName:null,surname:"Dinca",slug:"valentina-dinca",fullName:"Valentina Dinca"},{id:"206985",title:"Ph.D.",name:"Alexandra",middleName:null,surname:"Palla Papavlu",slug:"alexandra-palla-papavlu",fullName:"Alexandra Palla Papavlu"},{id:"207048",title:"Dr.",name:"Mihaela",middleName:null,surname:"Filipescu",slug:"mihaela-filipescu",fullName:"Mihaela Filipescu"}]},{id:"24748",doi:"10.5772/24134",title:"Deconvolution of Long-Pulse Lidar Profiles",slug:"deconvolution-of-long-pulse-lidar-profiles",totalDownloads:2164,totalCrossrefCites:0,totalDimensionsCites:9,abstract:null,book:{id:"1356",slug:"lasers-applications-in-science-and-industry",title:"Lasers",fullTitle:"Lasers - Applications in Science and Industry"},signatures:"Ljuan L. 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Stoyanov",authors:[{id:"55686",title:"Dr.",name:"Ljuan",middleName:null,surname:"Gurdev",slug:"ljuan-gurdev",fullName:"Ljuan Gurdev"},{id:"61273",title:"Dr.",name:"Tanja",middleName:null,surname:"Dreischuh",slug:"tanja-dreischuh",fullName:"Tanja Dreischuh"},{id:"61274",title:"Prof.",name:"Dimitar",middleName:"Vassilev",surname:"Stoyanov",slug:"dimitar-stoyanov",fullName:"Dimitar Stoyanov"}]},{id:"24745",doi:"10.5772/24024",title:"Laser Pulse Application in IVF",slug:"laser-pulse-application-in-ivf",totalDownloads:4055,totalCrossrefCites:7,totalDimensionsCites:9,abstract:null,book:{id:"1356",slug:"lasers-applications-in-science-and-industry",title:"Lasers",fullTitle:"Lasers - Applications in Science and Industry"},signatures:"Carrie Bedient, Pallavi Khanna and Nina Desai",authors:[{id:"55004",title:"Dr.",name:"Nina",middleName:null,surname:"Desai",slug:"nina-desai",fullName:"Nina Desai"},{id:"127713",title:"Dr.",name:"Carrie",middleName:null,surname:"Bedient",slug:"carrie-bedient",fullName:"Carrie Bedient"},{id:"127714",title:"Dr.",name:"Pallavi",middleName:null,surname:"Khanna",slug:"pallavi-khanna",fullName:"Pallavi Khanna"}]},{id:"68795",doi:"10.5772/intechopen.88860",title:"Preparation, Characterization, and Applications of Carbonaceous Mesophase: A Review",slug:"preparation-characterization-and-applications-of-carbonaceous-mesophase-a-review",totalDownloads:1350,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"Carbonaceous mesophase with a nematic liquid crystal structure possesses an easily graphitizable characteristic and can be used as a promising raw material to prepare anisotropic carbon and graphite materials with high performance and multifunction. Therefore, the carbonaceous mesophase occupies a pivotal and irreplaceable position in many frontier and cutting-edge fields. The controllable preparation and characterization of carbonaceous mesophase derived from a model molecule (i.e., naphthalene) are presented, especially the formation, development, and transformation of anisotropic liquid crystalline mesophase in the synthetic naphthalene pitch during the process of liquid-phase carbonization (350–450°C). The increasing applications of naphthalene-based carbonaceous mesophase as an ideal precursor material for fabricating representative advanced carbon materials with high added value (e.g., mesophase pitch-derived coke, mesocarbon microbeads, mesophase pitch-based carbon foam, high-modulus mesophase pitch-based carbon fibers, and high-thermal-conductivity carbon-based composites, etc.) are reviewed in detail in this chapter.",book:{id:"7965",slug:"liquid-crystals-and-display-technology",title:"Liquid Crystals and Display Technology",fullTitle:"Liquid Crystals and Display Technology"},signatures:"Guanming Yuan and Zhengwei Cui",authors:[{id:"308403",title:"Prof.",name:"Guanming",middleName:null,surname:"Yuan",slug:"guanming-yuan",fullName:"Guanming Yuan"},{id:"309210",title:"Dr.",name:"Zhengwei",middleName:null,surname:"Cui",slug:"zhengwei-cui",fullName:"Zhengwei Cui"}]},{id:"24737",doi:"10.5772/24285",title:"Production of Optical Coatings Resistant to Damage by Petawatt Class Laser Pulses",slug:"production-of-optical-coatings-resistant-to-damage-by-petawatt-class-laser-pulses",totalDownloads:3245,totalCrossrefCites:4,totalDimensionsCites:8,abstract:null,book:{id:"1356",slug:"lasers-applications-in-science-and-industry",title:"Lasers",fullTitle:"Lasers - Applications in Science and Industry"},signatures:"John Bellum, Patrick Rambo, Jens Schwarz, Ian Smith, Mark Kimmel, Damon Kletecka and Briggs Atherton",authors:[{id:"56477",title:"Dr.",name:"John",middleName:"C.",surname:"Bellum",slug:"john-bellum",fullName:"John Bellum"},{id:"120423",title:"Dr.",name:"Patrick",middleName:null,surname:"Rambo",slug:"patrick-rambo",fullName:"Patrick Rambo"},{id:"120424",title:"Dr.",name:"Jens",middleName:null,surname:"Schwarz",slug:"jens-schwarz",fullName:"Jens Schwarz"},{id:"120425",title:"Mr.",name:"Ian",middleName:null,surname:"Smith",slug:"ian-smith",fullName:"Ian Smith"},{id:"120426",title:"Mr.",name:"Mark",middleName:null,surname:"Kimmel",slug:"mark-kimmel",fullName:"Mark Kimmel"},{id:"120427",title:"Mr.",name:"Damon",middleName:null,surname:"Kletecka",slug:"damon-kletecka",fullName:"Damon Kletecka"},{id:"120428",title:"Dr.",name:"Briggs",middleName:null,surname:"Atherton",slug:"briggs-atherton",fullName:"Briggs Atherton"}]}],mostDownloadedChaptersLast30Days:[{id:"71926",title:"An Overview of Polymer-Dispersed Liquid Crystals Composite Films and Their Applications",slug:"an-overview-of-polymer-dispersed-liquid-crystals-composite-films-and-their-applications",totalDownloads:1185,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Inherent and incredible properties of liquid crystals (LC) such as optical and dielectric anisotropy make them special candidates for flat-panel display devices; bi-stable reflective displays; high-definition spatial light modulators; switchable windows; haze-free normal- and reverse-mode light shutter devices; projectors; optical, thermal and strain sensors; tuneable lenses; etc. Non-linear response of LC material to the applied electric field is very useful in the above-mentioned applications. When a low molecular weight LC material is doped in a high molecular weight polymer matrix to obtain polymer-dispersed liquid crystal (PDLC) films, it offers flexibility and mechanical strength (structural stabilization) to the composite films—PDLC devices. Depending upon the concentration of monomer/polymer, these composite films are classified as polymer-stabilized liquid crystal (PSLC), PDLC and holographic PDLC (HPDLC) films. Depending upon the process conditions, we get phase-separated randomly dispersed micron-sized LC droplets in a continuous polymer matrix. These nematic LC droplets exhibit light scattering transmission properties depending on their orientation, which can be controlled by external electric field. This chapter gives deep insight about operating principle, phase separation techniques involved, alignment of LC and controlling LC droplet morphology of PDLC films to obtain desired properties. In order to improve the optical efficiency and to obtain the desired result from PDLC films, various guest entities such as dye and nanomaterials are doped in the host LC material. This chapter also accounts for various possible LC dopants desired for improving the electro-optic (EO) and dielectric properties of PDLC devices. Various applications of PDLC composite films are also described in this chapter.",book:{id:"7965",slug:"liquid-crystals-and-display-technology",title:"Liquid Crystals and Display Technology",fullTitle:"Liquid Crystals and Display Technology"},signatures:"Anuja Katariya Jain and Rajendra R. Deshmukh",authors:[{id:"34437",title:"Dr.",name:"Rajendrasing",middleName:"Rajesing",surname:"Deshmukh",slug:"rajendrasing-deshmukh",fullName:"Rajendrasing Deshmukh"},{id:"318245",title:"Dr.",name:"Anuja",middleName:null,surname:"Katariya-Jain",slug:"anuja-katariya-jain",fullName:"Anuja Katariya-Jain"}]},{id:"71353",title:"Cholesteric Liquid Crystal Polyesteramides: Non-Viral Vectors",slug:"cholesteric-liquid-crystal-polyesteramides-non-viral-vectors",totalDownloads:597,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Polyesteramides PNOBDME (C34H38N2O6)n, Poly[oxy(1,2-dodecane)-oxy-carbonyl-1,4-phenylene-amine-carbonyl-1,4-phenylene-carbonyl-amine-1,4-phenylene-carbonyl], and PNOBEE (C26H22N2O6)n, Poly[oxy(1,2-butylene)-oxy-carbonyl-1,4-phenylene-amine-carbonyl-1,4-phenylene-carbonyl-amine-1,4-phenylene-carbonyl], have been designed and synthesized as cholesteric liquid crystals (LCs)—through a condensation reaction between 4- 4′-(terephthaloyl-diaminedibenzoic chloride) (NOBC) and racemic glycol, DL-1,2-dodecanediol or DL-1,2-butanediol, respectively—as chemical modifications of multifunctional cholesteric LC polyesters, involving new properties but holding the precursor helical macromolecular structures. The new compounds have been characterized by 1H and 13C-NMR, COSY and HSQC, exhibiting two 1H-independent sets of signals observed for each enantiomer, attributed to two diastereomeric conformers, gg and gt, of the torsion containing the asymmetric carbon atom in the spacer. They have also been characterized by x-ray diffraction with synchrotron radiation source. Thermal behaviour of the new compounds is studied by thermogravimetric (TG) and differential scanning calorimetry (DSC) analysis. The substitution of the ester groups in the mesogen by amide groups causes an increase of thermal stability with respect to the precursors. Optical rotatory dispersion (ORD) is evaluated. Morphology of powdered PNOBDME exhibits spherical clusters of about 5 μm in diameter homogeneously dispersed. Molecular models show helical polymeric chains with stereoregular head-tail, isotactic structure, explained as due to the higher reactivity of the primary hydroxyl with respect to the secondary one in the glycol through the polycondensation reaction. Besides being biocompatible, these synthetic polyesteramides have proved to act as non-viral vectors in gene therapy and be able to transfect DNA to the nucleus cell. Similar new cationic cholesteric liquid crystal polyesters have also been synthesized in our laboratory.",book:{id:"7965",slug:"liquid-crystals-and-display-technology",title:"Liquid Crystals and Display Technology",fullTitle:"Liquid Crystals and Display Technology"},signatures:"Mercedes Pérez Méndez and José Fayos Alcañiz",authors:[{id:"205972",title:"Dr.",name:"Mercedes",middleName:null,surname:"Pérez Méndez",slug:"mercedes-perez-mendez",fullName:"Mercedes Pérez Méndez"},{id:"316150",title:"Prof.",name:"José",middleName:null,surname:"Fayos Alcañíz",slug:"jose-fayos-alcaniz",fullName:"José Fayos Alcañíz"}]},{id:"72382",title:"Introductory Chapter: Nematic Liquid Crystals",slug:"introductory-chapter-nematic-liquid-crystals",totalDownloads:657,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"7965",slug:"liquid-crystals-and-display-technology",title:"Liquid Crystals and Display Technology",fullTitle:"Liquid Crystals and Display Technology"},signatures:"Irina Carlescu",authors:[{id:"258032",title:"Prof.",name:"Irina",middleName:null,surname:"Carlescu",slug:"irina-carlescu",fullName:"Irina Carlescu"}]},{id:"57062",title:"Optical Properties of Complex Oxide Thin Films Obtained by Pulsed Laser Deposition",slug:"optical-properties-of-complex-oxide-thin-films-obtained-by-pulsed-laser-deposition",totalDownloads:1527,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The market for thin films of complex oxides obtained by different deposition techniques is increasing exponentially in last decades due to large variety of possible application such as high-efficient solar cell, optoelectronic devices, etc. pulsed laser deposition (PLD) is a versatile growth technique and recently became more attractive for industrial applications due to the possibility to obtain crystalline thin films on a large area. Laser processing techniques were successfully used to obtain thin films with good optical properties starting from simple oxides, such as Sm2O3, ZrO2, etc., to more complex lead-free materials: SrxBa1−xNb2O6 (SBN) and Na1/2Bi1/2TiO3−x%BaTiO3, or superconductive oxide YBa2Cu3O7−δ. When oxide thin films are designated for electronic and optoelectronic devices or for solar cells, the optical properties and the thickness must be well known. For this purpose, the spectroscopic ellipsometry technique was developed. Ellipsometry is a powerful technique to determine the optical properties of thin films especially when the thicknesses of thin films are in a nanometer range.",book:{id:"6059",slug:"laser-ablation-from-fundamentals-to-applications",title:"Laser Ablation",fullTitle:"Laser Ablation - From Fundamentals to Applications"},signatures:"Valentin Ion, Andreea Andrei, Maria Dinescu and Nicu Doinel\nScarisoreanu",authors:[{id:"32241",title:"Dr.",name:"Maria",middleName:null,surname:"Dinescu",slug:"maria-dinescu",fullName:"Maria Dinescu"},{id:"156567",title:"MSc.",name:"Andreea",middleName:null,surname:"Andrei",slug:"andreea-andrei",fullName:"Andreea Andrei"},{id:"181341",title:"Dr.",name:"Valentin",middleName:null,surname:"Ion",slug:"valentin-ion",fullName:"Valentin Ion"},{id:"181362",title:"Dr.",name:"Nicu D.",middleName:null,surname:"Scarisoreanu",slug:"nicu-d.-scarisoreanu",fullName:"Nicu D. Scarisoreanu"}]},{id:"56891",title:"Multi-Beam Multi-Target Pulsed Laser Deposition of AZO Films with Polymer Nanoparticles for Thermoelectric Energy Harvesters",slug:"multi-beam-multi-target-pulsed-laser-deposition-of-azo-films-with-polymer-nanoparticles-for-thermoel",totalDownloads:1389,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In comparison with metallic thermoelectric films, oxide films with artificial nanodefects have been seldom studied. And there has been no report on the incorporation of island-shaped organic nanoparticles. We describe a new approach to introduce nanometer-sized phonon scatterers in aluminum-doped ZnO (AZO) thermoelectric thin films–concurrent multi-beam multi-target-pulsed laser deposition and the matrix-assisted pulsed laser evaporation (MBMT-PLD/MAPLE). The approach was used to make nanocomposite thin films of AZO matrix with evenly dispersed poly(methyl methacrylate) (PMMA) nanoparticles. The introduction of the nanoparticles enhanced phonon scattering with consequent decrease of thermal conductivity by 20%. The electrical conductivity did not decrease after the addition of the second phase, as it would be predicted by Wiedemann-Franz law, but improved by 350% over pure AZO film. The thermoelectric figure of merit of the nanocomposite film became twice that of the pure AZO film. Taking advantage of room-temperature deposition, optimized AZO nanocomposite films are expected to be used in real applications, such as thin film modules deposited on flexible polymeric substrates for ubiquitous harvesting of the waste heat.",book:{id:"6059",slug:"laser-ablation-from-fundamentals-to-applications",title:"Laser Ablation",fullTitle:"Laser Ablation - From Fundamentals to Applications"},signatures:"Abdalla M. Darwish, Sergey S. Sarkisov, Paolo Mele and Shrikant\nSaini",authors:[{id:"186848",title:"Prof.",name:"Abdalla",middleName:null,surname:"Darwish",slug:"abdalla-darwish",fullName:"Abdalla Darwish"},{id:"212023",title:"Dr.",name:"Sergey",middleName:null,surname:"Sarkisov",slug:"sergey-sarkisov",fullName:"Sergey Sarkisov"},{id:"217105",title:"Dr.",name:"Paolo",middleName:null,surname:"Mele",slug:"paolo-mele",fullName:"Paolo Mele"},{id:"217106",title:"Dr.",name:"Shrikant",middleName:null,surname:"Saini",slug:"shrikant-saini",fullName:"Shrikant Saini"}]}],onlineFirstChaptersFilter:{topicId:"1222",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. 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His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. 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Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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