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Löfgren’s Syndrome

Written By

Shiyu Wang and Shailendra Singh

Submitted: 19 February 2021 Reviewed: 11 March 2021 Published: 30 March 2021

DOI: 10.5772/intechopen.97154

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Löfgren’s syndrome presents as acute sarcoid arthritis, with a triad of hilar adenopathy, acute polyarthritis and erythema nodosum. Löfgren’s syndrome is self-limited, erythema nodosum, hilar adenopathy and acute polyarthritis usually resolve within a few weeks to months, however polyarthritis can last for up to 2 years. Treatment involves symptomatic control with NSAIDs/colchicine or oral glucocorticoids until symptoms resolve, if disease is resistant to these therapies, hydroxychloroquine, methotrexate or infliximab can be used. Löfgren’s syndrome is a rare presentation of sarcoidosis occurring in only about 5–10% of sarcoid patients. It is, however, important to recognize as it is the most common form of acute sarcoid arthritis and prompt treatment can prevent unnecessary prolonged discomfort for patients.


  • Löfgren’s Syndrome
  • Sarcoidosis
  • Polyarthritis
  • Hilar adenopathy
  • Erythema nodosum

1. Introduction

Löfgren’s syndrome is an acute manifestation of sarcoidosis. Sarcoidosis is a disease characterized by noncaseating granulomas throughout multiple body systems, most commonly involving the lungs (> 90% cases), often manifesting as hilar adenopathy. A small subset of patients (~10%) will develop joints symptoms, which can manifest as either acute or chronic arthritis. Löfgren’s syndrome is the most common presentation of acute sarcoid arthritis, occurring in about 5–10% of sarcoid cases, presenting as classical triad of acute polyarthritis, erythema nodosum and hilar adenopathy.


2. Epidemiology

Sarcoidosis is a disease with prevalence of about 10 to 20 per 100,000 people, it affects a wide variety of patients, but there are certain predilections and patterns for higher disease activity. Geographic area, ethnicity, gender and age seem to play important roles in incidence and presentation of disease [1, 2]. Various geographic locations have been studied, and there seems to be clustering of sarcoidosis incidence around certain geographic areas, with northern countries (such as Scandinavia) having much higher incidence than other areas [3]. Ethnicity also has a distinct pattern, with African Americans, Scandinavians, Afro Caribbeans, Irish, Puerto Rican and North Africans having highest incidence, though this seems to be affected by geographical location as well [3, 4]. There are also differences in disease presentation between different ethnicities; African Americans seem to have more severe disease presentation than Caucasians [2]. Lowest incidence occurs in Spain and Japan [3, 4]. Women are overall more affected by sarcoidosis than men, though interestingly, the age of diagnosis is almost 10 years later in women than men in many populations [3, 4]. There also seem to be difference in disease presentation between women and men, with women potentially experiencing more musculoskeletal related symptoms [3]. Sarcoidosis incidence also increases with family history of the disease; studies have shown that alleles on short arm of chromosome 6 seem to confer increased risk (HLA DR 11, 12, 14, 15, 17) or protection (HLA DRI, DR4) from disease [5].

Löfgren’s syndrome follows many of the same epidemiologic trends of sarcoidosis. It affects women more than men, with Scandinavian ethnicity having the highest incidence [6, 7]. There also seems to be a temporal clustering of incidence, with rates highest in the months from March to July [6]. The age of onset was, however; significantly lower for Löfgren’s syndrome than sarcodosis, at 39 years old versus 47 years old [7]. There also are differences between sexes in regards to presentation, women are more likely to present with erythema nodosum, whereas men are more likely to have inflammation or arthritis of ankles without erythema nodosum [8]. Various genetic factors and alleles have been associated with Löfgren’s syndrome, some protective and leading to better outcomes (HLA DQB1*0201, DRB1*03) while others are associated with more severe disease and worse outcomes (CCR2, HLA DQ2, DR3) [6, 9, 10, 11, 12].


3. Etiology

The etiology of sarcoidosis, and by extension Löfgren’s syndrome, is poorly understood. Granulomatous inflammation leads to eventual noncaseating granulomas in various organs. Formation of granulomas is due to exaggerated cell mediated immune response to antigens. The exact antigen(s) that stimulate sarcoidosis is unclear at this point in time. Many studies analyzing a large number of patients have not found one factor(s) that clearly causes sarcoidosis [13], possibly due to there being many different underlying causes of sacroidosis that leads to similar presentations. Some of the possible etiologies explored to date are environmental exposures and infectious agents.

3.1 Environmental exposure

Certain chemical elements (Beryllium, Zirconium, Aluminum) have been shown to cause graulomatous disease in lungs of patients with occupational exposure to these elements, while they themselves do not cause sarcoidosis, various studies have investigated if other environmental exposures could [14, 15, 16]. Specifically, rescue workers exposed to World Trade Center dust and debris developed new onset sarcoidosis, possible due to exposure to a yet unknown component of the dust [17].

3.2 Infectious agent

Mycobacterium and Propionibacteria have been studied as possible causes of sarcoidosis [18, 19]. Mycobacterium tuberculosis causes granulmatous caseations similar to those seen in sarcoidosis, and there have been Mycobacterium tuberculosis components found in sacroidosis tissue [20]. Propionibacteria acnes have also been found in lymph nodes of sarcoidosis patients [19]. Despite these findings, there has been no casual relationship found between these infectious agents and sacroidosis. Further evidence to support an infectious etiology of sarcoidosis is that transplantations of various organs have been shown to induce sarcoidosis in recipient [21, 22, 23].


4. Pathophysiology

The pathophysiology of sarcoidosis, and by extension Löfgren’s syndrome, involves activation of immune cells by as of yet unknown antigen(s). While the end result is graumloma formation, there are quite a few steps before this stage.

Antigen presenting cells (APCs), either macrophages or dendritic cells, phagocytose the as of yet unknown antigen(s), and then presents this antigen(s) to Helper CD4+ T cells. These Helper T cells then expresses various inflammatory cytokines including: interferon-gamma, Tumor necrosis factor (TNF), interleukin (IL)-2, IL-17 and IL-22 [24]. IL-17 recruits T Helper 17 (Th17) cells which then produce even more inflammatory cytokines, primarily interferon-gamma [25]. All these inflammatory mediators cause fusion of APCs into multinucleated giant cells, the APCs and multinucleated giant cells then cluster to form granulomas.

This process seems to occur most prominent and commonly in the lungs, with alveolar macrophages often the first to aggregate to form granulomas. This process can occur in other areas of the body, as evidence by up to 30% of patient experiencing extrapulmonary symptoms (Figure 1) [26].

Figure 1.

Non-caseating granuloma (Samir at the English-language Wikipedia, CC BY-SA 3.0 <>, via Wikimedia Commons).

4.1 Erythema Nodosum and acute polyarthritis

In Löfgren’s syndrome, in addition to pulmonary granolumas (represented as hilar adenopathy), there are also manifestations of erythema nodosum and acute polyarthritis. Erythema nodosum is caused by delayed type hypersensitivity reaction from exposure to antigens. Its exact pathophysiology is not fully understood, but may be due to immune complex deposition in venules of subcutaneous fat, inciting an inflammatory reaction and granuloma formation [27]. Acute polyarthritis also has poorly understood pathogenesis, but may be due increased inflammatory milieu within the body, leading to transient inflammatory arthritis.


5. Presentation

Löfgren’s syndrome presents classically as a triad of hilar lympadenopathy, erythema nodosum and acute polyarthritis. Often constitutional symptoms occur concurrently with the above triad, most commonly manifesting as fever, fatigue and malaise. Age of onset is generally under or around 40 years of age. More rare symptoms include uveitis along with blurry vision and light sensitivity [28]. There is variability in presentation between different sexes [8].

5.1 Hilar lymphadenopathy

Hilar lyphadenopathy is a classic finding of pulmonary sarcoidosis, making it ubiquitous in Löfgren’s syndrome. It is a radiographic term for enlarged mediastinal lymph nodes, most often those surrounding the pulmonary hila or root of the lung, where the lungs connect to the trachea and heart. Often the enlargement is bilateral and symmetric, though the right side may be slightly more prominent. Chest radiograph is required for definitive diagnosis, and there are five stages, as discussed below. These stages do not represent disease activity, just anatomical findings on chest radiography [29]. Generally, hilar lympadenopathy will regress within 1 year [30]. Though not exclusively caused by bilateral hilar lympadenopathy, respiratory symptoms are often the first presentation that prompts obtaining a chest radiograph, where hilar lymphadenopathy is first discovered in a patient. These respiratory symptoms most commonly are coughing, dyspnea and chest pain (Table 1 and Figures 2 and 3).

Stages of Pulmonary SarcoidosisFeatures
Stage 0Normal chest radiograph
Stage IBilateral hilar lymphadenopathy
Stage IIBilateral hilar lymphadenopathy + Diffuse infiltrative lung damage
Stage IIIDiffuse infiltrative lung damage
Stage IVLung fibrosis1

Table 1.

Stages of pulmonary sarcoidosis.

The Foundations in Diagnostic Pathology Series, Pulmonary Pathology – Chapter 17.

Figure 2.

Anterior–posterior and lateral chest radiograph of bilateral hilar lymphadenopathy (image courtesy of H. Bruce Dull, MD).

Figure 3.

Computed tomography of bilateral hilar lymphadenopathy (by James Heilman, MD - Own work, CC BY-SA 4.0,

5.2 Erythema Nodosum

Erythema nodosum presents as erythematous, tender, immobile nodules that are elevated and can join to form a plaque. Most commonly, they present on shins in Löfgren’s syndrome, though they can also appear on head and neck regions as well. These nodules are caused by subcutaneous inflammation, and are frequently accompanied by fevers and take a few days to develop. Spontaneous resolution typically occurs within eight weeks without scarring. There may be hyperpigmentation after resolution, but this is rare [27]. Relapsing erythema nodosum can develop; this represents poor control or failure of treatment of underlying chronic condition. Erythema nodosum is also more commonly seen in women with Löfgren’s syndrome, whereas men can have acute polyarthritis with no erythema nodosum (Figure 4) [8].

Figure 4.

Erythema nodosum of lower extremities (by James Heilman, MD - Own work, CC BY-SA 3.0,

5.3 Acute polyarthritis

Acute polyarthritis in Löfgren’s syndrome is typically symmetrical and oligoarticular (affecting 2 to 4 joints) initially. Most often, it involves the ankles bilaterally and then starts to affects other joints of the lower extremities such as knees and can also affect wrists and elbow joints as well. Bilateral ankle arthritis seems to be the most common initial manifestation of acute polyarthritis. Rarely, small joints of hands bilaterally can be involved [30]. Arthritis generally resolves within a few months, though it can persist up to 2 years, even with treatment. Cases of recurrent arthritis after treatment have also been described [31]. Men present with acute polyarthritis more commonly [8].


6. Evaluation and diagnosis

There are no definitive test or classification criteria for Löfgren’s syndrome, and though the classic triad of hilar lympadenopathy, erythema nodosum and acute polyarthritis are highly specific (> 95%), there are instances where not all components are presents in patients with Löfgren’s syndrome [32]. For successful evaluation of a patient with Löfgren’s syndrome, an accurate and detail history and physical must first be performed, usually followed up with a chest radiograph to confirm diagnosis. Biopsies may be indicated for definitive diagnosis of sarcoidosis if chest radiograph or other forms of imaging are inconclusive. Laboratory testing is generally not required.

6.1 History and physical exam

A detailed and accurate history and physical exam is essential for evaluation and diagnosis of Löfgren’s syndrome. Chronicity and specificity symptoms need to be elucidated and investigated. Importantly, history should uncover onset and location of acute polyarthritis, and whether there has been any migration of arthritis. Underlying arthritis or arthralgias should also be clarified, to ensure that the acute polyarthritis is indeed new and acute in nature, not a continuation of previous disease. Constitutional symptoms should also be inquired about, as acute onset of fever very often accompanies both the acute polyarthritis and development of erythema nodosum. Ask about respiratory symptoms, as they can be the first sign of previously unknown hilar lymphadenopathy. Keep in mind the differences in presentation between men and women, as women may not have presentation of acute polyarthritis and just erythema nodosum, whereas men may not present with erythema nodosum.

Physical exam should include detailed examination of lower extremities, neck and head regions for erythema nodosum. Joint examination of lower extremities as well as hands, wrists and elbows should be performed to see if there is pain, tenderness, swelling, redness and heat. Monitoring temperature can also be useful in determining if there is accompanying fever with these symptoms. A detailed cardiac, pulmonary and abdominal exam should be performed as hilar adenopathy and sarcoidosis in general can cause various manifestations and physical changes in these areas.

6.2 Chest radiography

Chest radiography should be obtained at least once on all patients suspected with Löfgren’s syndrome, it is an essential step to establishing if there his hilar lymphadenopathy. Section 5.1 describes findings and diagnostic criteria for hilar lymphadenopathy on chest radiograph. If chest radiography is inconclusive, high resolution computed tomography (HRCT) scan can be performed, and provides more detailed imaging and analysis of mesiatinum, able to identify in more detail the precise location and extent of lympadenopathy [33]. HRCT is not routinely recommended for evaluation and diagnosis of Löfgren’s syndrome.

6.3 Biopsies

Biopsies are generally limited to cases of Löfgren’s syndrome where HRCT or other imaging modalities cannot detect sarcoidosis, and/or disease is refractory to treatment or deviates from expected course. It is utilized to definitively obtain tissue samples that confirm diagnosis of sarcoidosis. Generally, bronchoalveolar lavage (BAL) is performed with endobronchial or transbronchial biopsies, endobronchial ultrasound (EBUS) biopsy can also be used for various positions and angles to attempt a needle aspiration biopsy of lympadenopathy. A triad of CD4 to CD8 cell ratio > 4, lymphocyte percentage > 16% and presence of noncaseating granulomas has 100% positive predictive value and 81% negative predictive value for diagnosis of sarcoidosis [34].

6.4 Laboratory and genetic testing

Laboratory testing is generally not required for evaluation and diagnosis of Löfgren’s syndrome. Many laboratory testing is non-specific and do not provide additional value. Exceptions may include angiotensin-converting enzyme (ACE) and ionized calcium. Studies have shown that patients with elevated ACE and ionized calcium may have increased risk for prolonged arthritis [35]. Tuberculosis skin or interferon-gamma testing should be performed at least once on patients suspected with Löfgren’s syndrome to rule out tuberculosis, which can mimic erythema nodosum as well as hilar adenopathy.

Genetic testing is not required for evaluation and diagnosis of Löfgren’s syndrome. Though some alleles and genes have been associated with Löfgren’s syndrome, they are more for academic research purposes rather than to diagnose the disease. Associations include: HLA DQB1*0201 and DRB1*03 have been found to be protective and lead to better outcomes, and CCR2, HLA DQ2 and DR3 have been found to be risk factors for worse outcomes [9, 10, 11, 12].


7. Differential diagnoses

Many conditions and diseases can cause erythema nodosum, polyarthritis and associated fever. These including: infections, drug reactions, malignancies, inflammatory bowel disease and other rheumatologic conditions. While chest radiograph with findings of hilar adenopathy can significantly increase specificity for Löfgren’s syndrome, it is not always necessary and a detailed history and physical should be able to differentiate many of the other differential diagnoses listed below.

7.1 Infections

A wide variety of infections can cause erythema nodosum and arthritis, which can manifest as reactive arthritis or infectious arthritis. These include bacterial: streptococcous, chalymdia, yersinina, salmonella, campylobacter and tubcerculosis. Fungal: coccidiomycosis, histoplasmosis, blastomycosis. Viral: hepatitis B and infectious mononucleosis. Reactive and infectious arthritis generally present initially in the knee joint, which can overlap with Löfgren’s syndrome, and the arthritis are also usually self-limited and acute. Therefore it can be difficult to distinguish between the two without chest radiography, but presence of hilar lymphadenopathy should exclude most of the infections listed above. The exception to this is tuberculosis, which can also present with hilar adenopathy, thus it is necessary to obtain tuberculosis skin or interferon-gamma testing to rule out tuberculosis infection.

7.2 Drug reactions

Drug reactions that can cause erythema nodosum include: oral contraceptives, penicillins, sulfonamides, bromides, iodides and TNF Alpha inhibitors. Though drug reactions can cause fever, very rarely do they cause arthritis. Cessation of offending drug also often resolves symptoms. Thus, if there is no presence of acute polyarthritis, distinguishing a drug reaction from Löfgren’s syndrome is clear.

7.3 Malignancies

Malignancies that can cause erythema nodosum include lymphoma, leukemia and carcinomas. These malignancies can also be associated with fever, but also very rarely cause arthritis. They can, however, cause hilar lymphadenopathy, thus it is important to delineate presence of acute polyarthritis.

7.4 Inflammatory bowel disease (IBD)

Ulcerative colitis and Crohns disease can cause erythema nodosum with associated fever as well as enteropathic arthritis. Enteropathic arthritis can present sporadically and intermittently, and can be mistaken for acute polyarthritis. Therefore, it is difficult to distinguish between inflammatory bowel disease and Löfgren’s syndrome, chest radiography should be obtained to detect for presence of hilar adenopathy. IBD generally does not cause hilar lymphadenopathy.

7.5 Other rheumatologic conditions

Rheumatologic conditions such as Behcet disease and Sweet syndrome can also cause erythema nodosum, arthritis with associated fevers. Behcet syndrome causes polyarthritis of lower extremity joints, very similar to Löfgren’s syndrome. Sweet syndrome itself does not cause arthritis, but is associated with rheumatoid arthritis, IBD and Behcet syndrome, all of which can cause arthritis. Sweet syndrome is associated with a characteristic rash that present as erythematous plaques, which should be differentiated from erythema nodosum. Neither condition is associated with hilar lymphadenopathy, thus chest radiography should be obtained to distinguish them from Löfgren’s syndrome.


8. Treatment/management

Löfgren’s syndrome is largely a self-limited disease, the erythema nodosum, acute polyarthritis and hilar lymphadenopathy resolves usually within a few weeks to months, most cases resolve within 1 year. Polyarthritis has been known to last up to 2 years. Treatment is largely supportive and goal is symptomatic control. NSAIDs are first line for anti-inflammatory properties to ameliorate discomfort of fever, erythema nodosum and arthritis; colchcine can also be used for this purpose. In severe or refractory cases, glucocorticoids can be used, which needs to be tapered off of once symptoms have been resolved. Further interventions with methotrexate or hydroxychloroquine can also be used, and infiximab beyond that [36].


9. Prognosis

Prognosis of Löfgren’s syndrome is excellent; most patients achieve complete resolution of symptoms without recurrence in 6 months to 2 years. Cases have been described of recurrence of symptoms or progression to chronic disease, but these are exceedingly rare [35].


10. Conclusions

Löfgren’s syndrome is a rare disease that is often misdiagnosed or under diagnosed. The constellation of symptoms of erythema nodosum, acute polyarthritis (most commonly bilaterally in ankle and under 2 months since time of onset) as well as hilar lymphadenopathy in a young patient (under 40 years of age) should raise very high suspicions for this disease. Prompt recognition and treatment of this disease can save much stress and pain for patients afflicted by it.

Conflict of interest

The authors declare no conflict of interest.


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Written By

Shiyu Wang and Shailendra Singh

Submitted: 19 February 2021 Reviewed: 11 March 2021 Published: 30 March 2021