\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"7077",leadTitle:null,fullTitle:"Celiac Disease - From the Bench to the Clinic",title:"Celiac Disease",subtitle:"From the Bench to the Clinic",reviewType:"peer-reviewed",abstract:"Celiac disease (CD) occurs in about 1% of people worldwide. Diagnosis rates are increasing due to a true rise in incidence, rather than increased awareness and detection. CD affects genetically susceptible individuals who are triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal chronic inflammation, and most patients have circulating antibodies against tissue transglutaminase. Our understanding of the basic and clinical aspects of CD increases, which is as a major health problem of almost global occurrence. Case finding, distinguishing CD from other gluten-sensitive conditions, better care, and balanced use of resources are the current challenges.",isbn:"978-1-78985-050-5",printIsbn:"978-1-78985-049-9",pdfIsbn:"978-1-83881-758-9",doi:"10.5772/intechopen.73847",price:100,priceEur:109,priceUsd:129,slug:"celiac-disease-from-the-bench-to-the-clinic",numberOfPages:100,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9effb55d4ab18dca9bcb8d40e34930f8",bookSignature:"Luis Rodrigo and Carlos Hernández-Lahoz",publishedDate:"January 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7077.jpg",numberOfDownloads:5175,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:9,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 17th 2018",dateEndSecondStepPublish:"May 8th 2018",dateEndThirdStepPublish:"July 7th 2018",dateEndFourthStepPublish:"September 25th 2018",dateEndFifthStepPublish:"November 24th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",biography:"Dr. Luis Rodrigo, MD, is an Emeritus Professor of Medicine at the University of Oviedo, Spain. He has been the chief of Gastroenterology Service at the HUCA Hospital in Oviedo for more than forty years. He obtained a Ph.D. in 1975 and since then has developed a long career in teaching and research. He has published 707 scientific papers, 425 written in English and 282 in Spanish. He has participated as the main investigator in forty-five clinical trials and has directed forty doctoral theses. He has contributed actively to the formation of about 100 specialists in gastroenterology working in his hospital and other centers in Spain and abroad. He has written around thirty-five chapters in books and edited twenty-four books in gastroenterology and hepatology. His areas of interest are celiac disease and autoimmune-associated diseases.",institutionString:"University of Oviedo",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"16",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"88551",title:"Dr.",name:"Carlos",middleName:null,surname:"Hernández-Lahoz",slug:"carlos-hernandez-lahoz",fullName:"Carlos Hernández-Lahoz",profilePictureURL:"https://mts.intechopen.com/storage/users/88551/images/system/88551.jpg",biography:"Carlos Hernández-Lahoz, MD, received his PhD from Medical School, University of Zaragoza (Spain), in 1968. He has been a Clinical Neurologist in Asturias General Hospital (Oviedo, Spain), since 1972.\nHe is an Associate Professor of Neurology, Medical School, University of Oviedo (Spain), since 1990. Dr. Hernández-Lahoz is Consultant of Neurology at University Asturias Central Hospital (HUCA), Oviedo (Spain), since 1990 and Consultant of Neurology, Clinic of Neurology (Oviedo, Spain), since 2011.\nDr. Hernández-Lahoz is Member of the Spanish Neurological Society (SEN), Royal Academy of Medicine and other Institutions. As author, he has published more than 100 articles and book chapters about Neurology, some of them about Neurogluten.",institutionString:"University of Oviedo",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"900",title:"Clinical Immunology",slug:"pure-immunology-clinical-immunology"}],chapters:[{id:"64874",title:"Introductory Chapter: Celiac Disease - An Overview",doi:"10.5772/intechopen.82723",slug:"introductory-chapter-celiac-disease-an-overview",totalDownloads:1077,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Luis Rodrigo and Carlos Hernandez-Lahoz",downloadPdfUrl:"/chapter/pdf-download/64874",previewPdfUrl:"/chapter/pdf-preview/64874",authors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],corrections:null},{id:"64464",title:"Challenges with Point-Of-Care Tests (POCT) for Celiac Disease",doi:"10.5772/intechopen.81874",slug:"challenges-with-point-of-care-tests-poct-for-celiac-disease",totalDownloads:1203,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Current screening test for celiac disease involves blood test in centralized pathology laboratories, typically performing enzyme-linked immune-sorbent assays (ELISA) to detect specific celiac disease antibodies. Most of the current available celiac disease antibody tests detect anti-gliadin (AGA), anti-endomysial (EMA), anti-transglutaminase (tTG), or deamidated gluten peptide (DGP) antibodies from serum or whole blood samples. It requires blood collection from untreated celiac patients, which is often invasive and inconvenient. There is a rapid growth in demand for noninvasive celiac tests for the early and fast diagnosis of celiac disease to help potential celiac patients obtain results and take corresponding actions. Over the last decade, several point-of-care tests (POCT) have been introduced to the market, but these tests have not been widely accepted by clinicians. Moreover, the 2009 NICE guideline CG 86 recommended that self-tests and/or POCT for celiac disease should not be used as a substitute for laboratory-based tests. Here, we provide a background on the evolution of POCT for celiac disease. We discuss general principle of operation for the known commercial kits as well as the use of various antigens and antibodies in different tests developed over the years. Finally, we discuss challenges for future research directions in celiac disease POCTs.",signatures:"Huan Wu, Michael Wallach and Olga Shimoni",downloadPdfUrl:"/chapter/pdf-download/64464",previewPdfUrl:"/chapter/pdf-preview/64464",authors:[{id:"259057",title:"Associate Prof.",name:"Olga",surname:"Shimoni",slug:"olga-shimoni",fullName:"Olga Shimoni"},{id:"279220",title:"Prof.",name:"Michael",surname:"Walach",slug:"michael-walach",fullName:"Michael Walach"},{id:"279221",title:"Ms.",name:"Huan",surname:"Wu",slug:"huan-wu",fullName:"Huan Wu"}],corrections:null},{id:"63217",title:"Genotype DQ2.5/DQ2.2 (ββ2/ββ2) and High Celiac Disease Risk Development",doi:"10.5772/intechopen.80578",slug:"genotype-dq2-5-dq2-2-2-2-and-high-celiac-disease-risk-development",totalDownloads:922,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. CD is considered one of the most well-characterized autoimmune diseases, having a described environmental factor, a well-established pathogenesis, associated genetic factors, and a well-established laboratory diagnosis, although it is still considered a difficult-to-classify disease. In the last decades, advances in laboratory diagnosis with the emergence of molecular biology techniques have allowed a specific characterization of the CD-associated genotypes and, although clinically the disease management was not modified by this factor, the follow-up of patients at risk of CD development has greatly benefited from the possibility of specifically finding the inherited genotype, and whether it represents a greater or lesser risk for developing the disease. In some populations, it is already possible to calculate the exact risk associated to the inherited genome by each individual, but the genotypes available in several countries sometimes disregard the relevance of searching beyond the genotypes DQ2.5/DQ2.5, DQ2.5/DQ8, and DQ2.5/DQ2.2, which also present a high risk for developing the disease.",signatures:"Yanna Karla de Medeiros Nóbrega",downloadPdfUrl:"/chapter/pdf-download/63217",previewPdfUrl:"/chapter/pdf-preview/63217",authors:[{id:"255018",title:"Ph.D.",name:"Yanna",surname:"Nóbrega",slug:"yanna-nobrega",fullName:"Yanna Nóbrega"}],corrections:null},{id:"63229",title:"The Emerging Role of the Autophagy Process in Children with Celiac Disease: Current Status and Research Perspectives",doi:"10.5772/intechopen.80692",slug:"the-emerging-role-of-the-autophagy-process-in-children-with-celiac-disease-current-status-and-resear",totalDownloads:909,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Celiac disease (CD) affects approximately 1% of the population in Europe and North America, but the number of patients currently undiagnosed is estimated to be far higher than that of diagnosed cases owing to the presence of prevalent forms with nonspecific symptoms. The toxicity of gliadin in children with CD is not destroyed through digestion with gastropancreatic enzymes. An innate immunity to gliadin plays a key role in the development of CD. Autophagy, a physiological catabolic process, plays also a crucial role in the pathogenesis of several inflammatory diseases. Recent studies have described functional involvement of the regulation of autophagy within a pediatric CD cohort. Furthermore, the contribution of autophagy has been highlighted in the degradation and in the reduction of extracellular release of gliadin peptides, thus suggesting novel molecular targets to counteract gliadin-induced toxicity in CD.",signatures:"Mauro Bozzola, Federico Manai, Chiara Montalbano, Alberto Azzalin,\nElena Bozzola, Alberto Villani and Sergio Comincini",downloadPdfUrl:"/chapter/pdf-download/63229",previewPdfUrl:"/chapter/pdf-preview/63229",authors:[{id:"85383",title:"Prof.",name:"Mauro",surname:"Bozzola",slug:"mauro-bozzola",fullName:"Mauro Bozzola"},{id:"251603",title:"Dr.",name:"Chiara",surname:"Montalbano",slug:"chiara-montalbano",fullName:"Chiara Montalbano"},{id:"251639",title:"Dr.",name:"Elena",surname:"Bozzola",slug:"elena-bozzola",fullName:"Elena Bozzola"},{id:"251645",title:"Dr.",name:"Alberto",surname:"Villani",slug:"alberto-villani",fullName:"Alberto Villani"},{id:"268999",title:"Dr.",name:"Federico",surname:"Manai",slug:"federico-manai",fullName:"Federico Manai"},{id:"269000",title:"Dr.",name:"Alberto",surname:"Azzalin",slug:"alberto-azzalin",fullName:"Alberto Azzalin"},{id:"269003",title:"Dr.",name:"Sergio",surname:"Comincini",slug:"sergio-comincini",fullName:"Sergio Comincini"}],corrections:null},{id:"63167",title:"Complications of Celiac Disease",doi:"10.5772/intechopen.80465",slug:"complications-of-celiac-disease",totalDownloads:1065,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Celiac disease is a small bowel disorder, due to defect in gluten diet, leading to mucosal inflammation, villous atrophy and crypt hyperplasia. For the diagnosis of celiac disease, one has to be on gluten free diet. Due to commonly available various serologic tests and histopathology, celiac disease, can be categorized as asymptomatic, silent or potential. Between 80 and 90% of all patients with celiac disease remained undiagnosed. Because of this late diagnosis, patients may develop various complications including anemia, bone loss, depression and cancers. Patients may have different types of anemia including iron deficiency, folic acid or B12 deficiency. Any of these may occurred separately or may be manifested together. The same variation is seen in bone loss, starting from osteopenia, osteomalacia to osteoporosis and even dysplasias. Patient may develop lymphoma, gastric or oesophageal carcinomas as well. Celiac disease is also associated with other autoimmune illnesses as it is an autoimmune process by itself. The complications of celiac disease, is either due to direct consequence of celiac, or due to significant damage to the small intestine. With the early detection and diagnosis, the symptomatology and complications of celiac disease can be spared.",signatures:"Rakhshinda Jabeen",downloadPdfUrl:"/chapter/pdf-download/63167",previewPdfUrl:"/chapter/pdf-preview/63167",authors:[{id:"256143",title:"Associate Prof.",name:"Rakhshinda",surname:"Jabeen",slug:"rakhshinda-jabeen",fullName:"Rakhshinda Jabeen"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"932",title:"Acute Pancreatitis",subtitle:null,isOpenForSubmission:!1,hash:"b9e4aebaf0e8a2dd617fe38a5d3b2bff",slug:"acute-pancreatitis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/932.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5388",title:"Human Helminthiasis",subtitle:null,isOpenForSubmission:!1,hash:"6f2002f4cb6e246a51ed8688e076db4d",slug:"human-helminthiasis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5388.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5752",title:"Celiac Disease and Non-Celiac Gluten Sensitivity",subtitle:null,isOpenForSubmission:!1,hash:"47dfc5b8378b01d915127fa3c1169a90",slug:"celiac-disease-and-non-celiac-gluten-sensitivity",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5752.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5122",title:"Colorectal Cancer",subtitle:"From Pathogenesis to Treatment",isOpenForSubmission:!1,hash:"5ab8ff026cf9fbd8e3b0097d7f11fe2c",slug:"colorectal-cancer-from-pathogenesis-to-treatment",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5122.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"983",title:"Pancreatitis",subtitle:"Treatment and Complications",isOpenForSubmission:!1,hash:"062521454256bb4a388ce6fd638dbf1a",slug:"pancreatitis-treatment-and-complications",bookSignature:"Luis Rodrigo Saez",coverURL:"https://cdn.intechopen.com/books/images_new/983.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4478",title:"Acute and Chronic Pancreatitis",subtitle:null,isOpenForSubmission:!1,hash:"4e7a1b71b21315524a24e78819fb7dd3",slug:"acute-and-chronic-pancreatitis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/4478.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis 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Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6440.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7125",title:"Iron Deficiency Anemia",subtitle:null,isOpenForSubmission:!1,hash:"25d82a6ea6c9d80b195bb40aad06be49",slug:"iron-deficiency-anemia",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/7125.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6061",title:"Ascites",subtitle:"Physiopathology, Treatment, Complications and Prognosis",isOpenForSubmission:!1,hash:"ead9b3e5c36413f9ff2c3129fbc57574",slug:"ascites-physiopathology-treatment-complications-and-prognosis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6061.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"81444",slug:"corrigendum-to-the-role-of-ultra-radical-surgery-in-the-management-of-advanced-ovarian-cancer-state-",title:"Corrigendum to: The Role of Ultra-Radical Surgery in the Management of Advanced Ovarian Cancer: State of the Art",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/81444.pdf",downloadPdfUrl:"/chapter/pdf-download/81444",previewPdfUrl:"/chapter/pdf-preview/81444",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/81444",risUrl:"/chapter/ris/81444",chapter:{id:"78061",slug:"the-role-of-ultra-radical-surgery-in-the-management-of-advanced-ovarian-cancer-state-of-the-art",signatures:"Felicia Elena Buruiana, Lamiese Ismail, Federico Ferrari and Hooman Soleymani Majd",dateSubmitted:"March 15th 2021",dateReviewed:"April 8th 2021",datePrePublished:"August 12th 2021",datePublished:"October 6th 2021",book:{id:"10342",title:"Ovarian Cancer",subtitle:"Updates in Tumour Biology and Therapeutics",fullTitle:"Ovarian Cancer - Updates in Tumour Biology and Therapeutics",slug:"ovarian-cancer-updates-in-tumour-biology-and-therapeutics",publishedDate:"October 6th 2021",bookSignature:"Gwo-Yaw Ho and Kate 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He received his B.Sc. in Science\nand his M.Sc. in Chemistry from the University of Allahabad,\nIndia, in 2004 and 2006, respectively. He received his Ph.D.\ndegree in Chemistry from the University of Allahabad in 2010.\nDr Arpit Sand is a reviewer for international journals including\nCarbohydrate Polymers, the International Journal of Biological Macromolecules,\nFibers and Polymers, etc. He is also a life member of the Indian Science Congress\nand the Green Chemistry Network centre, and he has authored more than 20 international research articles and review articles in reputed SCI journals. He has made\na significant contribution to the field of the modification and characterization of\ngraft copolymers. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"74643",title:"Averaged No-Regret Control for an Electromagnetic Wave Equation Depending upon a Parameter with Incomplete Initial Conditions",doi:"10.5772/intechopen.95447",slug:"averaged-no-regret-control-for-an-electromagnetic-wave-equation-depending-upon-a-parameter-with-inco",body:'The research in the field of electromagnetism is set to become a vital factor in biomedical technologies. Those studies included several areas like the usage of electromagnetic waves for probing organs and advanced MRI techniques, microwave biosensors, non-invasive electromagnetic diagnostic tools, therapeutic applications of electromagnetic waves, radar technologies for biosensing, the adoption of electromagnetic waves in medical sensing, cancer detection using ultra-wideband signal, the interaction of electromagnetic waves with biological tissues and living systems, theoretical modeling of electromagnetic propagation through human body and tissues and imaging applications of electromagnetic.
Actually, the principal goal of the study is to control such electromagnetic waves to be compatible with some biomedical needs like X-rays in the framework of medical screening and wireless power transfer of electromagnetic waves through the human body [1] where we want to make waves closer to a desired distribution.
In this chapter, we consider a linear wave equation with a potential term
In this study, we consider an optimal control problem for electromagnetic wave equation depending upon a parameter and with missing initial conditions. We use the method of no-regret control which was introduced firstly in statistics by Savage [2] and later by Lions [3, 4] where he used this concept in optimal control theory, and its related idea is “low-regret” control to apply it to control distributed systems of incomplete data which has the attention of many scholars [5, 6, 7, 8, 9, 10, 11, 12], motivated by various applications in ecology, and economics as well [13]. Also, we use the notion of average control because our system depends upon a parameter, Zuazua was the first who introduced this new concept in [14].
The rest of this chapter is arranged as follows. Section 2, lists the definition of the problem we are studying. Section 3, is devoted to the study of the averaged no-regret control and the averaged low-regret control for the electromagnetic wave equation. Ultimately, we prove the existence of a unique average low-regret control, and the characterization of the average optimal is given in Section 4. Finally, we make a conclusion in Section 5.
Consider a bounded open domain
where
Denote by
where
In this work, we aim to characterize the solution
independently of
A classical method to obtain the optimality system is then to solve the minmax problem
but
Those controls
As in [16, 17], we introduce the averaged no-regret control defined by.
Definition 1 [1] We say that
Let us start by giving the following important lemma.
Lemma 1 For all
where
which has a unique solution in
Use (9) and apply Green formula to get
■
The no-regret control seems to be hard to characterize (see [11]), for this.
reason we relax the no-regret control problem by making some quadratic perturbation as follows.
Definition 2 [17] We say that
Using (9) the problem (13) can be written as
And thanks to Legendre transform (see [18, 19]), we have
Then, the averaged low-regret control problem (9) is equivalent to the following classical optimal control problem
where
In the recent section, we aim to find a full characterization for the averaged no-regret control and averaged low-regret control via optimality systems.
Theorem 1.1 There exists a unique averaged low-regret control
Let
We know that
This implies the following bounds
where
By similar way an by using (22) we obtain
Then, from (21) we deduce that there exists a subsequence still denoted
Also, because of continuity w.r.t. data we have
In other hand, use (24) and (22) to apply the convergence dominated theorem and, we have
From (25) we deduce the existence of a subsequence still be denoted by
then
where
Again, by limit uniqueness
The uniqueness of
After proving existence and uniqueness, we aim in the next theorem to give a full description to the average low-regret control for the electromagnetic wave equation.
Theorem 1.2 For all
with
for all
Now, let us introduce
So that for every
We finally define another adjoint state
Then (35) becomes
■
The previous Theorem gives a low-regret control characterization. For the no-regret control, we need to prove the convergence of the sequence of averaged low-regret control to the averaged no-regret control. Then, we announce the following Proposition.
For some constant
then
this gives (40), (41), (42) and (43). The bound (43) follows by a way similar to (24).
From energy conservation property with (43) and (44).
we find (45).
To get
Lemma 2 The averaged low-regret control
let us prove
take
i.e. is an averaged no-regret control. ■.
Finally, we can present the following theorem giving a full characterization the average no-regret control.
Theorem 1.3 The average no-regret control
with
and
solution to
Again, by (41) and dominated convergence theorem
The rest of equations in (53) leads by a similar way, except the convergences of initial data
From (43) and (44) we deduce the convergences of
and
As we have seen, the averaged no-regret control method allows us to find a control that will optimize the situation of the electromagnetic waves with missing initial conditions and depending upon a parameter. The method presented in the paper is quite general and covers a wide class of systems, hence, we could generalize the situation to more control positions (regional, punctual,…) and different kinds of missing data (source term, boundary conditions,…).
The results presented above can also be generalized to the case of other systems which has many biomedical applications. This problem is still under consideration and the results will appear in upcoming works.
This work was supported by the Directorate-General for Scientific Research and Technological Development (DGRSDT).
The research in the field of electromagnetism is set to become a vital factor in biomedical technologies. Those studies included several areas like the usage of electromagnetic waves for probing organs and advanced MRI techniques, microwave biosensors, non-invasive electromagnetic diagnostic tools, therapeutic applications of electromagnetic waves, radar technologies for biosensing, the adoption of electromagnetic waves in medical sensing, cancer detection using ultra-wideband signal, the interaction of electromagnetic waves with biological tissues and living systems, theoretical modeling of electromagnetic propagation through human body and tissues and imaging applications of electromagnetic.
Actually, the principal goal of the study is to control such electromagnetic waves to be compatible with some biomedical needs like X-rays in the framework of medical screening and wireless power transfer of electromagnetic waves through the human body [1] where we want to make waves closer to a desired distribution.
In this chapter, we consider a linear wave equation with a potential term
In this study, we consider an optimal control problem for electromagnetic wave equation depending upon a parameter and with missing initial conditions. We use the method of no-regret control which was introduced firstly in statistics by Savage [2] and later by Lions [3, 4] where he used this concept in optimal control theory, and its related idea is “low-regret” control to apply it to control distributed systems of incomplete data which has the attention of many scholars [5, 6, 7, 8, 9, 10, 11, 12], motivated by various applications in ecology, and economics as well [13]. Also, we use the notion of average control because our system depends upon a parameter, Zuazua was the first who introduced this new concept in [14].
The rest of this chapter is arranged as follows. Section 2, lists the definition of the problem we are studying. Section 3, is devoted to the study of the averaged no-regret control and the averaged low-regret control for the electromagnetic wave equation. Ultimately, we prove the existence of a unique average low-regret control, and the characterization of the average optimal is given in Section 4. Finally, we make a conclusion in Section 5.
Consider a bounded open domain
where
Denote by
where
In this work, we aim to characterize the solution
independently of
A classical method to obtain the optimality system is then to solve the minmax problem
but
Those controls
As in [16, 17], we introduce the averaged no-regret control defined by.
Definition 1 [1] We say that
Let us start by giving the following important lemma.
Lemma 1 For all
where
which has a unique solution in
Use (9) and apply Green formula to get
■
The no-regret control seems to be hard to characterize (see [11]), for this.
reason we relax the no-regret control problem by making some quadratic perturbation as follows.
Definition 2 [17] We say that
Using (9) the problem (13) can be written as
And thanks to Legendre transform (see [18, 19]), we have
Then, the averaged low-regret control problem (9) is equivalent to the following classical optimal control problem
where
In the recent section, we aim to find a full characterization for the averaged no-regret control and averaged low-regret control via optimality systems.
Theorem 1.1 There exists a unique averaged low-regret control
Let
We know that
This implies the following bounds
where
By similar way an by using (22) we obtain
Then, from (21) we deduce that there exists a subsequence still denoted
Also, because of continuity w.r.t. data we have
In other hand, use (24) and (22) to apply the convergence dominated theorem and, we have
From (25) we deduce the existence of a subsequence still be denoted by
then
where
Again, by limit uniqueness
The uniqueness of
After proving existence and uniqueness, we aim in the next theorem to give a full description to the average low-regret control for the electromagnetic wave equation.
Theorem 1.2 For all
with
for all
Now, let us introduce
So that for every
We finally define another adjoint state
Then (35) becomes
■
The previous Theorem gives a low-regret control characterization. For the no-regret control, we need to prove the convergence of the sequence of averaged low-regret control to the averaged no-regret control. Then, we announce the following Proposition.
For some constant
then
this gives (40), (41), (42) and (43). The bound (43) follows by a way similar to (24).
From energy conservation property with (43) and (44).
we find (45).
To get
Lemma 2 The averaged low-regret control
let us prove
take
i.e. is an averaged no-regret control. ■.
Finally, we can present the following theorem giving a full characterization the average no-regret control.
Theorem 1.3 The average no-regret control
with
and
solution to
Again, by (41) and dominated convergence theorem
The rest of equations in (53) leads by a similar way, except the convergences of initial data
From (43) and (44) we deduce the convergences of
and
As we have seen, the averaged no-regret control method allows us to find a control that will optimize the situation of the electromagnetic waves with missing initial conditions and depending upon a parameter. The method presented in the paper is quite general and covers a wide class of systems, hence, we could generalize the situation to more control positions (regional, punctual,…) and different kinds of missing data (source term, boundary conditions,…).
The results presented above can also be generalized to the case of other systems which has many biomedical applications. This problem is still under consideration and the results will appear in upcoming works.
This work was supported by the Directorate-General for Scientific Research and Technological Development (DGRSDT).
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