Standard laminales characteristics.
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These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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\r\n\tGlass-ceramics have been described as polycrystalline materials of fine microstructure that are produced by controlling the nucleation and crystal phases growth within the glass. The glass is firstly melted, produced to shape, and thermally converted into mostly crystalline ceramics. The distribution of these crystalline phases in the glass matrix increases the uniformity of the material and, by comparison, effectively limits crack growth. The technologies of glass-ceramic have developed rapidly in the past few decades due to the excellent mechanical and thermal properties of these materials. These properties are attractive to replace traditional materials and can also meet the technical requirements of new applications, such as radome and coatings. Glass ceramics are receiving great attention due to their diversity of applications, which have the potential to meet the recent requirements of advanced mechanical, optical and biomedical applications. This book covers a wide range of topics such as glass-ceramic forming, shaping, and production, structure, properties, testing and characterizations, nucleation and crystallization, application of building materials, military, electronics, cooking ceramics, machinable ceramics, biomedical and optical materials.
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Basheer Al-Naib is a Senior Lecturer at Universiti Teknologi Malaysia (UTM). He completed his post-doctorate in Material Engineering at Universiti SainsMalaysia (USM) between 2013 and 2014. He received his Ph.D. in Materials Engineering from USM in 2013. He obtained his Master and Bachelor degree in Chemical Engineering from the University of Baghdad and the University of Technology, IRAQ, respectively. He has over 30 years of academic and practical experience in the field of ceramic and metal composites; metal alloys; advanced ceramics; porous ceramics; ceramic-metal joining; materials characterizations and forming; ceramic insulators; ceramic membranes; thermoelectric energy conversion and ceramic coating. He is acknowledged at the practical level for solving specific problems related to material industries. This was evident through his research work issued with different publishers and international material engineering journals with high impact factors. 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Much attention has been given to developing new systems that fit with UWB applications as radar detection, biomedical imaging. The proposed UWB antenna is more likely to be used in the biomedical imaging applications as a system to detect breast cancer.
Breast cancer is the second deadly cancer for women, for more efficiency and an early detection, the biomedical field need new systems that should be safe, comfortable and sensible [1, 2]. The medical field already has its methods to detect breast cancer like X-ray mammography, magnetic resonance imaging (MRI), as efficient as those techniques are they are missing between 10 and 30% [2] of very early breast cancer stages.
The UWB microwave imaging is one of the techniques that has been developed, in the Hunt for the next techniques that will detect breast cancer in its early stages. The basis for microwave detection is to compare between the dielectric properties of a normal tissue and cancerous tissue, the result of the comparison gives a prediction of malignant tissue characteristics as it size, shape, placement, … [3].
The second part of this chapter, I present a microstrip antenna that we offer is circular in shape and, a priori, has a low gain and a narrow bandwidth. To meet the requirements of our specifications would be to expand the bandwidth. For this reason, we have developed a design methodology, which has enabled us to develop an antenna capable of meeting these requirements.
The reduction in size is also a consideration to take into account when designing this antenna, which would allow it to be more easily integrated into the system and reduce the size. For this, the certain techniques are used. Among these techniques, we will use the slot insertion at the level of the radiating element.
The design procedure followed consists of three steps:
The first step is to develop a structure with ULB characteristics.
The second step is used to optimize the performance of the structure developed in terms of adapting the impedance
The third step is to develop an antenna network.
UWB is defined as a system with a very large band, this large spectrum comes usually with some advantages as a low power, high debit of data, high time resolution, low-cost and an ease of implementation, resistance to interference and so on. Those advantages opened a wide range of UWB application to radar detection, biomedical imaging, and HD communication.
The definition of UWB is not a special one, the FCC (Federal Communication Commission) [4] defines it as a system with a bandwidth larger than 500 MHz or larger than 20% if we are working whit the relative bandwidth W/fc (W is the width of the band and fc is the carrier frequency). The UWB is being defined by its very large band that is 7.5 GHz between 3.1 GHz and 10.6 GHz for a limitation of the power emission level −41.3 dBm/MHz [4].
The UWB communication systems uses a very short pulse duration of tens hundreds of nanoseconds, and sense the pulse and the bandwidth are inversely proportional, the shorter pulses is the wider the spectrum is going to be.
Antennas would match the UWB requirements if it have a bandwidth greater than 500 MHz defined at −10 dB according to the FCC, or to have a relative bandwidth more than 20% [4, 5].
Where
The efficiency of an UWB antenna can be evaluated by the specter efficiency, the evaluation matching has to be over the whole range of frequencies.
The signal passing through the UWB antennas is a very short pulse, the shorter the pulse is more likely the UWB antenna’s response is going to be distorted and delayed due to the ripple after the pulse called the rippel effect [5].
The rippling effect is caused by the geometry of the antenna, and it causes frequency translation, dispersion or delay on the transition reducing the speed of data transmission [6].
This section is dedicated to the design and the performance of the proposed antenna. The design proposed is a notched coplanar antenna. The geometry of the antenna consisted of a 25 × 30 mm2, Rogers RT5850 substrate with
Geometry of the antenna proposed.
The two main characteristics that effect the performance of the antenna was the inner radius of the circle R and the laminate thickness. The gap between the transmission line and the ground structure was optimized so that the antenna’s impedance can match a 50 Ω SMA port.
Figure 2 shows the return loss or more known as the parameter S11 of the antenna, the spectrum of Figure 2 contains the UWB frequency band spectrum. The spectrum’s antenna range is form 2.8 GHz to 10.9 GHz and contains tow resonate frequencies 6.1 GHz and 9.8 GHz with their S11 parameters −46 dB and −35 dB respectively. The antenna can be easily used in the UWB (3.1 GHz – 10.6 GHz) applications [4].
The return loss S11 as a function of frequency.
VSWR is a parameter that describes the power that is reflected by the antenna. It is a function of the reflection parameter.
Figure 3 shows the graph of the VSWR of the antenna proposed, we can tell from the graph that the VSWR is under tow in all the bandwidth so the VSWR can be considered as good.
VSWR as a function of frequency.
The main focus of the chapter is to design a UWB antenna that can be easily implemented in UWB application with a small dimension and a larger frequency spectrum. Figure 4 shows the radiation pattern of the antenna proposed for the frequency of 9.8 GHz, the color red defined the higher range of the gain and the green refers to the lower part [7].
Radiation pattern of the proposed antenna.
The parametric study is done in two parts the first part was to choose the laminate and then the value of the radius of the patch.
The antennas that was compared to the antenna proposed in the chapter is: a coplanar microstrip antenna with defected ground structure for UWB applications [7]. A printed UWB antenna with full ground plane also for WBAN applications and CPW-fed slot patch antenna [8, 9, 10]. The study is to compare the proposed geometry on tree different Rogers laminates. Table 1 shows the characteristics of the tree laminates.
Laminates | Laminate characteristics | |
---|---|---|
Standard thickness | Standard copper cladding | |
Laminate 1 | 0.787 mm | 35 μm |
Laminate 2 | 1.57 mm | 35 μm |
Laminate 3 | 3.175 mm | 35 μm |
Standard laminales characteristics.
Figure 5 presents the return loss of the antenna with the different laminates, according to the results of Figure 5, the laminate Rogers with a thickness of 3.175 mm was chosen to complete the parametric study. The variation of the radius is altered around the theoretical radius to optimize the performance of the antenna. The patch of the antenna is separated into two parts, first where the cutouts are and the second part is the ring that contour the cutouts, this parametric study consisted on varying the inner radius of the patch, the radius of the circle that contain the cutouts. Figure 6 shows a relation between the radius and the depth of the return loss,
Effect of the thickness of the substrate.
Effect of the inner radius on the antenna.
Table 2 shows the difference between four UWB antennas, the proposed antenna has a wider band, includes all UWB frequencies, the highest gain is around 5.6 dBi.
The patch of radius (r) is produced on a substrate of the FR-4 type (dielectric permittivity εr = 4.3, thickness h = 1.575 mm) and of dimensions ls = 25 mm and ws = 25 mm. A rectangular slot is inserted on the radiating element (u × s) ensuring its miniaturization. The latter is supplied by microstrip line of wm east width in order to adapt it to a 50 Ω supply [11, 12]. Figure 7 shows the proposed antenna.
Antenna geometry.
From Table 3values, we perform a simulation on the CST software [13].
Parameters | r | lm | wm | tm | lg | u | s | v | g | k |
---|---|---|---|---|---|---|---|---|---|---|
mm | 8 | 9 | 2.25 | 0.035 | 8 | 1 | 10 | 4 | 0.27 | 5 |
The dimensions of the circular miniature printed antenna.
The parameter S11 is the coefficient that most concerns designers of printed antennas because it represents the reflection coefficient which plays the role of disturbance on data transmission [14]:
We see that the coefficient S is around −22.35 dB for a resonant frequency of 3.8 GHz, the bandwidth is 3.17–15 GHz, as shown in Figure 8 [15].
Return loss of circular miniature printed antenna.
Figure 9 gives us the variation of the gain of our antenna as a function of the frequency. It happens to be between 2 and 4.87 dBi on the frequency band which interests us, which is 3.1–10.6 GHz. This limitation of the gain could be improved by a possible networking of antennas [16].
Gain diagram of circular patch antenna.
The 3D radiation pattern at the 8 GHz frequency. We can say that the radiation is focused on both sides of the antenna. At the frequency f = 8 GHz the gain of antenna is 4.28 dBi (Figure 10) and a directivity of antenna is 4.87 dBi (Figure 11).
Gain diagram (3D) of circular patch antenna.
Directivity diagram (3D).
Figures 12 and 13 show the far-field gain and far-field directivity in plane E. For both the opening of the main lobe at -3 dB for the frequency 8 GHz is 66.9˚ [16, 17].
Far-field gain (2D) of circular miniature printed antenna.
Far-field directionality (2D).
We are going to play on three parameters, to see its effect on the behavior of this antenna.
The parameter effect r (RO) (the radius of the radiating part) on coefficient S11 (Figure 14) and gain (Figure 15):
S11 parameter:
Gain:
The parameter effect lg (length of the ground plane) on coefficient S11 (Figure 16) and gain (Figure 17):
S11 parameter:
Gain:
S11 parameter:
Gain:
Return loss with effect of the antenna radius.
Gain diagram with effect of the antenna radius.
Return loss with effect of the length of the antenna ground plane.
Gain diagram with effect of length of the antenna ground plane.
Return loss with effect of the antenna slot location.
Gain diagram with effect of the antenna slot location.
We are going to make our antenna network (Figure 20) from the previous antenna with some modifications in terms of the parameters and its values in order to have the desired results (Table 4).
Antenna array structure.
Parameter | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
mm | 9 | 7 | 1.5 | 0.035 | 6 | 4 | 9 | 12 | 1.8 | 13 | 0.18 | 5 |
Dimensions of the array antenna.
S11 parameter:
In Figure 21, we see that the coefficient S11 is of the order of −42 dB for a resonant frequency of 6.08 GHz, we obtained exactly the bandwidth that interests us, which is [2.7 10.6 GHz] [18].
Gain:
Return loss of array antenna.
Figure 22 gives us the variation of the gain of our antenna as a function of the frequency. Note that the gain has increased to 7.6 dBi on the frequency band [3.1–10.6 GHz]. This networking of antennas has allowed us to increase the gain [19].
Gain diagram of array antenna.
At the frequency of 6.14 Hz in Figure 23 (Gain Diagram) and Figure 24 (Directivity Diagram), we can say that the radiation is focused on both sides of the antenna but this time we have side lobes. With a gain of 6.7 dBi and a directivity of 7.6 dBi at f = 6.14 [20, 21].
Radiation diagram:
Gain diagram of array antenna.
Directivity diagram.
Figures 25 and 26 show respectively the far-field gain and far-field directivity in plane E. The opening of the main lobe at -3 dB for the frequency 6.14 GHz is 32.8˚ [22, 23, 24, 25].
Farfield gain.
Farfield directivity.
In the first part of this chapter, the new coplanar antenna with cutouts on a circular patch demonstrate advantages: larger frequency spectrum, a good VSWR, improved parameter S11. The geometry of the patch was calculated and design with CST microwave studio. The antenna was design for UWB application more likely the microwave imaging in the range from 3.1 GHz to 10.6 GHz. Moreover the antennas are smaller than traditional antennas, and as a coplanar it can be easy to implement. Also, enhancing gain will be a good improvement by making this antenna in an array due to its small size.
In the second part of this chapter, we proposed a miniature circular patch antenna intended for an application in medical imaging.
The antenna network satisfies the imposed requirements satisfactorily and exhibits ultra broadband (ULB) behavior. In fact, the simulations under CST resulted in a reflection coefficient at −10 dB between 2.6 GHz and 10.7 GHz.
We have shown by this study that the dimensions and shape of the ground plane could have a significant impact on the bandwidth of the structure.
Future work includes the fabrication of a prototype of the antenna, as well as measurements in anechoic chamber to verify the agreement between the measured and simulated results.
Due to the complexity of each human tissue, our antenna should be tested in different parts of the body to determine is the optimum distance of 20 mm is valid wherever the antenna is placed within the body. The implementation of an array of antennas will be also evaluated in future studies.
Ageing - whatever the age that characterizes it - cannot therefore be identified with a state of illness but must be considered a natural phenomenon that goes hand in hand with a progressive physiological and psychological transformation of the organism and that can determine - through an accentuated biological vulnerability - a greater propensity to illness [1].
Physical frailty is a condition of marked vulnerability to negative events caused by the reduction of functional reserves of multiple systems of the organism because of the ageing process and chronic polypathology. It is a condition that represents a risk factor of disability, hospitalization, institutionalization, and death [1]. But what determines frailty - not necessarily physical, but also cognitive or interpersonal - in an elderly person?
Biomedical sciences, neuroscience and epigenetics have increasingly analyzed the mechanisms that regulate structural-functional changes in the body in relation to environmental influences. Each person has his/her own biography; each body and nervous system has its own development and use. Frailty and strength emerge in the course and within an individual story, according to a life-span perspective.
Frailty and strength constitute an oxymoron that often originates from the same semantic source. Paradoxically, it is the frailty condition that allows the discovery or rediscovery of resources and potentialities.
Frailty and strength are recognized, interwoven with affections, their formation and realization. It is the affective experiences that contribute in a decisive way to structuring an individual’s personality, the feeling of security or precariousness, or the prevalence of one over the other.
Quintus Horatius Flaccus (Odi: IV, 4, v.65) argued that «
Frailty and strength interact, alternate and are continually shaped throughout life. Affectivity often represents its seismograph, but vulnerability can at the same time constitute the metronome of one’s emotional instances, especially the deepest ones. The notions of “frailty” and “affectivity” recalls an ontological condition, as intrinsic to the human dimension, and offer original perspectives of investigation for multiple issues affecting the elderly. These perspectives are well highlighted by the analyses of numerous themes of both frailty-vulnerability and affectivity-emotivity in ageing developed by different disciplines (anthropology, sociology, philosophy, biology, psychology, neuroscience, medicine). It becomes relevant to understand how frailty and affectivity interact in the course of ageing, depending on what has been experienced and learned, and on what existence and life in society continue to offer.
The importance of a multidimensional assessment of the elderly to define their state of health and well-being has long been recognised. Indeed, cognitive, affective, behavioural and functional factors interact closely with somatic and socio-environmental ones.
A l bio-psycho-social model can help us to define the most appropriate interventions to promote health in terms of the best possible quality of life. This approach attributes health to the intricate and variable interaction of biological, psychological, and social factors [1, 2].
There is no single way of ageing, but there are as many different ageing processes as there are humans [2]. Indeed, ageing is a gradual and continuous process of natural mutation for which many bodily functions begin a gradual decline [2]. The life-span perspective recognizes changes in the functional state as characteristic of the human being ageing process [3] and are considered characteristic of the
Considering the continuum that goes from pure ageing to pathological ageing, one can define
Different types of ageing patterns (
This type of classification provides a molecular assessment of individual ageing, reflective of personal lifestyle and medical history; indeed, ageotypes highlight the potential health risk factors and may ultimately be useful in monitoring the ageing process [2, 5]. Multimorbidity and polypharmacotherapy weakens the body and can predispose to accelerated ageing, resulting in frailty.
Frailty is certainly the most problematic expression of the ageing population [1, 2]. It is an integrated [6] and multidimensional [7] condition in which biological, functional, psychological, and social variables interact with each other. It may be relevant in identifying older people at risk of deteriorating mental health [8] and cognitive decline [9].
In the face of such a complex picture, there is yet no unambiguous operational definition of frailty that would make it possible to define a gold standard of evaluation. Experts belonging to the European Innovation Partnership on Active and Healthy (EIP-AHA) have identified two main approaches: the first concerns physical determinants (biomedical approach), while the second considers biological, cognitive, psychological, and socio-economic factors (bio-psycho-social approach). Indeed, a reliable assessment cannot be separated from the analysis of the affective, cognitive, and relational components [1].
Vulnerability should be considered as a predisposition of an individual exposed to a critical situation to slip into a more severe critical situation. Vulnerability and criticality define respectively a property of a process and a state within that process [11]. In this sense the definition of frailty proposed by Rozzini and Zanetti is explanatory [12]: «frailty is a condition of risk and vulnerability in the face of noxae of various kinds, which challenge the homeostatic balance of an organism. Frailty is predisposition to breakage, to damage when subjected to pressure».
Considering the above:
The shift towards higher order critical issues is the recurring scenario in the problems of the elderly population [11]. Indeed, chronicity can be considered the final state of a path of depletion of plastic capacity (Figure 1). According to a
Logical concatenations between the concepts of criticality and vulnerability. Adapted by Micheli [
The understanding of the route linking ageing, frailty and 2nd order criticalities and the distinction between frailty and 2nd order criticalities have not only a pathophysiological significance. They open operational perspectives. It has been demonstrated that the route from pure ageing to 2nd order criticalities is not a one-way street, and that a regression from frailty to pre-frailty and from the latter to a “non-frailty condition” is possible [13]. Indeed, frailty might be reversible or attenuated by interventions put in place to avoid its evolution over time [14]. Many conditions of (pre)frailty can reverse their direction, so that they can move in the direction of successful ageing. This is most true when traditional therapeutic approaches are combined with the promotion of healthy lifestyles. In old age, the potential and limits of plasticity are often monitored in the neurocognitive and rehabilitative fields. The prestigious Nature has dedicated a special issue to these themes. In the cover article “Prevention: activity is the best medicine” [15] you can see two people dancing. The evidence in favor of the protective role of healthy lifestyles for the maintenance of cognitive functions is well established.
The task now is to move from lifestyle factors to interventions to find out how what kind and much exercise, what kind of intellectual activity, what kind of diet, what kind of social support and engagement (and at what stage each of them) could influence the directions of ageing.
The question of how to promote healthy lifestyles in the adult and elderly population as a prevention intervention no longer arises only at a scientific level but at a social and political level.
Recent studies have underlined the existence of a significant association between lifestyle and frailty [16, 17]. All older people are at risk of developing frailty, although risk levels are substantially higher among people with comorbidities, poor socio-economic status, poor nutrition and sedentary lifestyles [16]. However, inappropriate lifestyles and some clinical risk factors are potentially counteracted by specific interventions and preventive actions [16].
The EIP-AHA Action Group A3 has developed several multidimensional tools capable of predicting short-term negative outcomes [18]. Several factors have been highlighted as useful for proper health planning: malnutrition, polypharmacotherapy, impairment of physical function and social isolation have been identified as those on which to act to mitigate fragility and its consequences [18].
Data from a recently published study [19] also point in this direction. The Barcelona Brain Health Initiative is a longitudinal cohort study initiated in 2017 that aims to understand and characterize the determinants of brain health and intellectual efficiency in middle-aged adults. A cohort of 4686 individuals aged between 40 and 65 has been established, with no history of neurological and/or psychiatric illness. The researchers collected demographic, socio-economic, clinical and health data, associating them with assessments of perceived health status and lifestyles (general health, physical activity, cognitive activity, socialization, sleep, diet and so on). The results underline the importance of healthy lifestyles to support brain health and intellectual efficiency [19].
Consistently with the above, it is believed that the prevention and treatment of frailty can only be based on:
promotion of healthy lifestyles.
promotion of social inclusion and social engagement
promotion of emotional relationships.
timely identification of clinical-functional fluctuations and “sentinel events” (falls, urinary incontinence, sensory deficit, delirium, …), which must be considered potential 1st order criticalities
diagnosis and treatment of all pathologies that can be responsible for asthenia, weight loss, reduced tolerance to effort, reduced physical strength and physical activity
intensive and frequent clinical monitoring of the elderly at risk
adaptation of daily living environments
reduced exposure of the frail elderly to environmental stresses (including hospitalization and unnecessary medical procedures)
Active and healthy ageing is a multidimensional concept referring to a situation where the elderly persists to participate in the formal labour market, engage in voluntary activities, and live healthy, independent, and safe lives as they get older.
Active ageing policies therefore require addressing several factors: encourage healthy lifestyles, ensure social involvement, provide opportunities for independent living, and enable possibilities for longer working life. Monitoring such policy implementation requires a comprehensive tool that encompasses the multitude of aspects of active and healthy ageing. The European Commission has made the Active Aging Index (AAI) available precisely to meet this need.
The AAI captures various facets of active ageing by measuring 22 indicators grouped into 4 domains: employment, participation in society, independent health and secure living, and capacity and enabling environment for active ageing (Figure 2). The AAI also provides a breakdown of results by gender to highlight potential differences in ageing between men and women. The index values range from 0 to 100. Higher values indicate a greater capacity to realize the unexpressed potential in old age. AAI offers a flexible framework that can be applied to different countries and at national as well as regional/local levels. It depicts the current situation and highlights the areas where future gains can be made. If computed on a regular basis, AAI allows to measure progress over time and helps to identify effective policy actions. The 2018 Active Ageing Index Analytical report reveals that since 2008 most European countries have improved their overall AAI scores [20]. This progress is probably due to increased attention to the elderly by society and politics and to the spread of a multidimensional and bio-psycho-social approach to the fight against frailty.
The AAI has been developed within the framework of the 2012 European Year for Active Ageing and Solidarity between Generations (EY2012). The index is made up by four domains each of which reflects a different aspect of active ageing.
The implementation of a bio-psycho-social approach to frailty allows an active and proactive management of a condition strongly related to chronicity, disability, and mortality. Frailty early identification can prevent or slow down the evolution towards negative outcomes, with a significant positive impact on the quality of life of the ageing population and on the health system and society as a whole [1].
The question is what the best screening protocols are and what types of intervention to carry out given the uniqueness of everyone’s ageing and the type of ageotype associated with it. Indeed, the lack of effectiveness of a purely pharmacological management of frailty should be analyzed in the light of its pathophysiology.
A progressive alteration of several physiological systems induced by the interaction between the ageing process (pure ageing) with several morbid processes and multiple psycho-social and environmental conditions are involved [2, 6, 7]. After all, if the pathogenesis of frailty is multifactorial, intervention on a single physiological system will not in itself resolve frailty or even prevent it [21]. The probability of becoming frail older people increases non-linearly in relation to the number of abnormal physiological systems, and the number of abnormal systems would seem to be more predictive than the individual abnormal system involved [21]. Notably, the non-linear relationship of accelerating likelihood of frailty as the number of abnormal systems escalates suggests that there could be a threshold beyond which there is an adverse downward spiraling nature to frailty etiology and progression. Implications are that a threshold loss of complexity, as indicated by number of systems abnormal, may undermine homeostatic adaptive capacity, leading to the development of frailty and its associated risk for subsequent adverse outcomes [21]. It also indicates that the replacement of any defective system may not be sufficient to prevent or ameliorate the whole health condition [21].
What has been indicated refers to the importance of a multidimensional approach to the elderly - and especially to the frail elderly - both in the evaluation and in taking charge of the individuals. To date, the comprehensive geriatric evaluation (CGA) is the most fruitful process to assess elderly people to optimize their subsequent management. Indeed, CGA has consistently shown its significant benefits for over 30 years [22].
However, the high speed with which the world’s population ages and is affected by chronic diseases, polypathology and functional impairment is unfortunately not yet accompanied by a strong, competent, and aware geriatric culture. This unfulfilled need contributes to the further exponential increase in adverse outcomes (2° order criticalities) and to the loss of psychophysical well-being and health (which means complete happiness, as we have previously defined it) in older people.
It is increasingly evident that there is a dual need to put existing applied health research knowledge into practice (the “
Gladman et al. [23] discussed several barriers to the implementation of the GCA, including guiding factors, professional factors, patient factors, professional interactions, incentives, resources, capacity for organizational change, as well as social, political, and legal factors. There is little point in not actively working on
Everything discussed urges geriatrics - nowadays a true medicine of complexity - to refine its cultural and operational tools and to make them available to a health system grappling with the growing problems posed by a progressively aging population.
The medicine of complexity suggests a model in which psychophysical well-being and disease are the result of complex, dynamic and unique interactions in the individual under examination: i.e., interactions between different components of the entire system. The human body is made up of interconnected, inter-reacting physiological systems, while the individual maintains a behaviour determined by experience and on the ability to adapt and interact with the environment.
The individual is therefore a dynamic, interacting, adaptable system in which the disease - and even more the polypathology - triggers a cause-and-effect model that cannot be considered linear. To this follows a situation of complexity that requires a new type of taking charge of the elderly patient. This approach to the patient accepts unpredictability and proposes solutions based on elements that are sometimes imperceptible but emerging to the clinical sensitivity of the health professional. Considering the above, two elements become substantial for a successful CGA: to conceive the individual frail elderly person as unique and complex; to put the clinical methodology at the heart of the patient approach. These concepts are having profound consequences, introducing working methodologies based on multidisciplinary, integration, implementation, contextualized work.
To make this a concrete reality, it is essential that geriatrics share with other professionals involved in the field the cultural values that belong to them, promoting multidisciplinary confrontation and integration, so that it is possible to build a vision of intent common to all specialists and operators of the multidisciplinary team that acts around the frail elderly.
Ageing has always affected and often frightened humans, which since ancient times has been well aware that the biological changes connected with the passing of the years induce a progressive weakening of functional capacities, a decay of physical or mental conditions, an increasing difficulty in carrying out tasks that were once easy to perform.
Publio Terenzio Afro (160 B.C.) referred to the physical ailments and privations that usually accompany senescence with the well-known sentence «
Health should be considered as the ability to identify and realize one’s aspirations, to satisfy one’s needs and to positively modify the surrounding environment. The elderly is in good health if they maintain a condition of self-sufficiency as much as possible, psychophysical well-being, and positive thinking about the future.
Frailty in the elderly requires a customized multidimensional approach that cannot be segmented into isolated interventions for each pathology, taking into account individual differences - not only clinical but also socio-relational and environmental differences - according to the principle of “taking care of the patient and not only of the disease”.
There are many health problems in the elderly, and one wonders whether it is appropriate to take action not only as health professionals but also individually to counter them or to stem the consequences: if each of us adopted healthy habits and made ourselves the bearer of them we would have done something - perhaps modest on an individual level but important on a collective level to counter the “silver tsunami” which could jeopardize our old age and the stability of our society.
The fight against frailty takes place in a life-span perspective. A bio-psycho-social model can help us to define the most appropriate interventions to promote the best quality of life. This approach attributes health to the intricate and variable interaction of biological, psychological, and social factors.
Such a multidimensional approach is fundamental when it comes to the elderly and the promotion of healthy and active ageing.
No funding was available to the author.
The authors declare that the manuscript was written in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
There are many ways to age and grow old can be frightening: all sorts of losses to deal with, a body and mind less vigorous and brilliant than it once was, sometimes memory becomes clouded, self-awareness diminishes and loved ones disappear. However, there are older people who make you want to grow old. They have not been spared by life, but for them growing old is like continuing their adventure. They seem to keep in the form of inner riches those outer ones they have lost and discover new possibilities and freedom. I thank the senior students at the University of the Third Age of Turin for being a source of inspiration and teachers of life. To them, who taught me what it means to have a soul that is always young, every effort I make is dedicated.
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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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DCs also have an important role in the induction and maintenance of tolerance. In response to infections, DCs drive the production of effector CD4+ T helper 1 (Th1) and CD8+ T cell-dominated immune responses. DCs can be designated to become tolerogenic and enhance regulatory T cells (Tregs) that regulate effector T cell responses, a process that is essential for the maintenance of immune homeostasis and control of autoimmune diseases and hypersensitivities. DCs can exist in three states: immature, semi-mature, and mature DCs. The difference between immature and mature DCs is distinctly based on variations occurring on a phenotypic level and functional level. Immature dendritic cells manifested characteristics of primitive cells, defined by expression of classical dendritic cell surface markers CD11c, CD11b and major histocompatibility complex class II (MHC-II). Phenotypic maturation is accomplished when DCs upregulate surface maturation markers such as CD80, CD83, and CD86.",book:{id:"7248",slug:"dendritic-cells",title:"Dendritic Cells",fullTitle:"Dendritic Cells"},signatures:"Ghada Mohammad Zaki Al-Ashmawy",authors:[{id:"255240",title:"Dr.",name:"Ghada",middleName:null,surname:"Al-Ashmawy",slug:"ghada-al-ashmawy",fullName:"Ghada Al-Ashmawy"}]},{id:"63198",doi:"10.5772/intechopen.79273",title:"Dendritic Cells: The Tools for Cancer Treatment",slug:"dendritic-cells-the-tools-for-cancer-treatment",totalDownloads:1217,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"During cancer immune editing, the immune system shapes tumor fate in three phases through the activation of innate and adaptive immune mechanisms. After the elimination and equilibrium phase, the escape phase represents the final phase in which immunologically sculpted tumors begin to grow progressively. In this chapter, we will discuss which efforts are made to restore the balance in favor of the immune system making use of dendritic cells (DCs). The first approach is adoptive cell transfer, in which autologous DCs are generated and activated ex vivo. Secondly, we will discuss attempts in which pro-inflammatory or pro-migratory factors are delivered to attract and activate DCs in situ. Both strategies have the general goal to activate and mature DCs able to induce a robust tumor-specific T cell response. In addition, this chapter will discuss the clinical impact of DC-based therapies in cancer treatment focusing on the safety, feasibility, immunological responses, and clinical outcome.",book:{id:"7248",slug:"dendritic-cells",title:"Dendritic Cells",fullTitle:"Dendritic Cells"},signatures:"Hanne Locy, Sarah Melhaoui, Sarah K. 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As a high number of molecules are available, synthesis of the most important cytokines, including tumor factor necrosis, interferons and interleukins will be presented. Here we also describe the relationships between those cytokines with some autoimmune diseases that are promoted by them.",book:{id:"6243",slug:"autoantibodies-and-cytokines",title:"Autoantibodies and Cytokines",fullTitle:"Autoantibodies and Cytokines"},signatures:"Vinicius L. Ferreira, Helena H.L. Borba, Aline de F. Bonetti, Leticia P.\nLeonart and Roberto Pontarolo",authors:null},{id:"62945",title:"Dendritic Cell Subsets, Maturation and Function",slug:"dendritic-cell-subsets-maturation-and-function",totalDownloads:2321,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Dendritic cells (DCs) are the most efficient and professional antigen-presenting cells of the immune system required for induction and dispersion of immune responses. DCs also have an important role in the induction and maintenance of tolerance. In response to infections, DCs drive the production of effector CD4+ T helper 1 (Th1) and CD8+ T cell-dominated immune responses. DCs can be designated to become tolerogenic and enhance regulatory T cells (Tregs) that regulate effector T cell responses, a process that is essential for the maintenance of immune homeostasis and control of autoimmune diseases and hypersensitivities. DCs can exist in three states: immature, semi-mature, and mature DCs. The difference between immature and mature DCs is distinctly based on variations occurring on a phenotypic level and functional level. Immature dendritic cells manifested characteristics of primitive cells, defined by expression of classical dendritic cell surface markers CD11c, CD11b and major histocompatibility complex class II (MHC-II). Phenotypic maturation is accomplished when DCs upregulate surface maturation markers such as CD80, CD83, and CD86.",book:{id:"7248",slug:"dendritic-cells",title:"Dendritic Cells",fullTitle:"Dendritic Cells"},signatures:"Ghada Mohammad Zaki Al-Ashmawy",authors:[{id:"255240",title:"Dr.",name:"Ghada",middleName:null,surname:"Al-Ashmawy",slug:"ghada-al-ashmawy",fullName:"Ghada Al-Ashmawy"}]},{id:"64077",title:"Role of Dendritic Cells in Parasitic Infections",slug:"role-of-dendritic-cells-in-parasitic-infections",totalDownloads:1459,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Dendritic cells comprise a complex array of cell populations that play a leading role in immune defense. In an immature state, they have the capacity to sense and uptake different antigens. Upon capturing antigens, they become activated, mature, and migrate to lymph nodes where they present antigen-derived peptides to naïve T cells. Due to these excellent surveillance properties, dendritic cells play an important role against parasitic infections. Also, dendritic cells are an important source of IL-12, which is a fundamental proinflammatory cytokine in the control of intracellular parasites. The aim of this chapter is to review the most important characteristics and functions of dendritic cells and their role in the control of infection by parasites.",book:{id:"7248",slug:"dendritic-cells",title:"Dendritic Cells",fullTitle:"Dendritic Cells"},signatures:"Laila Gutiérrez-Kobeh, Jorge Rodríguez-González, Jesús Argueta-\nDonohué, Rosalino Vázquez-López and Arturo A. Wilkins-\nRodríguez",authors:[{id:"233494",title:"Dr.",name:"Laila",middleName:null,surname:"Gutiérrez-Kobeh",slug:"laila-gutierrez-kobeh",fullName:"Laila Gutiérrez-Kobeh"},{id:"239829",title:"BSc.",name:"Arturo A.",middleName:null,surname:"Wilkins-Rodriguez",slug:"arturo-a.-wilkins-rodriguez",fullName:"Arturo A. 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In classic autoimmune diseases, it is well established that the pathology relates directly to the autoantibodies. However, it is increasingly recognised that autoantibodies are also found in many other disease areas, including cancers, cardiovascular and neurodegenerative diseases, as well infectious diseases such as malaria, albeit in such diseases it is unclear whether the autoantibodies play a direct role in the pathology or whether they are merely symptomatic of disease. Irrespective of whether they are causative or symptomatic of specific diseases though, there is increasing interest globally in exploring the clinical potential of circulating autoantibodies as diagnostic biomarkers. This chapter provides an overview of the diagnostic utility of autoantibody biomarkers in a range of disease areas and discusses their potential utility in disease staging, treatment monitoring and in prediction of immune-related adverse events. It also provides an overview of traditional and contemporary technological approaches to autoantibody biomarker discovery and validation, focusing on protein microarrays that are ideally suited to this important area of research.",book:{id:"6243",slug:"autoantibodies-and-cytokines",title:"Autoantibodies and Cytokines",fullTitle:"Autoantibodies and Cytokines"},signatures:"Farhanah Aziz, Muneera Smith and Jonathan M Blackburn",authors:null},{id:"62204",title:"Highlighting the Role of DC-NK Cell Interplay in Immunobiology and Immunotherapy",slug:"highlighting-the-role-of-dc-nk-cell-interplay-in-immunobiology-and-immunotherapy",totalDownloads:1872,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Dendritic cells (DCs) and natural killer (NK) cells are both part of the innate immune system, also playing crucial functions in the regulation of adaptive immune responses. In recent years, numerous works have demonstrated that DCs and NK cells mutually influence each other with major consequences in the type and effectiveness of elicited immune responses. Among other effects, DC-NK crosstalk can result in NK cell activation and DC maturation or deletion, depending on its activation status. In this chapter and after a brief overview of DCs and NK immunobiology, we focus on the process of DC-NK crosstalk, highlighting the relevance of rationally exploring this interplay in the development of more effective cancer immunotherapies.",book:{id:"7248",slug:"dendritic-cells",title:"Dendritic Cells",fullTitle:"Dendritic Cells"},signatures:"João Calmeiro, Mylene Carrascal, Célia Gomes, Amílcar Falcão,\nMaria Teresa Cruz and Bruno Miguel Neves",authors:[{id:"114266",title:"Prof.",name:"Bruno",middleName:"Miguel",surname:"Neves",slug:"bruno-neves",fullName:"Bruno Neves"},{id:"115592",title:"Prof.",name:"Maria Teresa",middleName:null,surname:"Cruz",slug:"maria-teresa-cruz",fullName:"Maria Teresa Cruz"},{id:"233883",title:"Prof.",name:"Amílcar",middleName:null,surname:"Falcão",slug:"amilcar-falcao",fullName:"Amílcar Falcão"},{id:"243998",title:"MSc.",name:"João",middleName:null,surname:"Calmeiro",slug:"joao-calmeiro",fullName:"João Calmeiro"},{id:"244001",title:"Dr.",name:"Mylene",middleName:null,surname:"Carrascal",slug:"mylene-carrascal",fullName:"Mylene Carrascal"},{id:"244004",title:"Dr.",name:"Célia",middleName:null,surname:"Gomes",slug:"celia-gomes",fullName:"Célia Gomes"}]}],onlineFirstChaptersFilter:{topicId:"55",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 16th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Rosa María Martínez-Espinosa is a Full Professor of Biochemistry and Molecular Biology at the University of Alicante, Spain, and has been the vice president of International Relations and Development Cooperation at this university since 2010. She created the research group in applied biochemistry in 2017 (https://web.ua.es/en/appbiochem/), and from 1999 to the present has made more than 200 contributions to Spanish and international conferences. Furthermore, she has around seventy-five scientific publications in indexed journals, eighty book chapters, and one patent to her credit. Her research work focuses on microbial metabolism (particularly on extremophile microorganisms), purification and characterization of enzymes with potential industrial and biotechnological applications, protocol optimization for genetically manipulating microorganisms, gene regulation characterization, carotenoid (pigment) production, and design and development of contaminated water and soil bioremediation processes by means of microorganisms. This research has received competitive public grants from the European Commission, the Spanish Ministry of Economy and Competitiveness, the Valencia Region Government, and the University of Alicante.",institutionString:"University of Alicante",institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"83122",title:"New Perspectives on the Application of Chito-Oligosaccharides Derived from Chitin and Chitosan: A Review",doi:"10.5772/intechopen.106501",signatures:"Paul Edgardo Regalado-Infante, Norma Gabriela Rojas-Avelizapa, Rosalía Núñez-Pastrana, Daniel Tapia-Maruri, Andrea Margarita Rivas-Castillo, Régulo Carlos Llarena-Hernández and Luz Irene Rojas-Avelizapa",slug:"new-perspectives-on-the-application-of-chito-oligosaccharides-derived-from-chitin-and-chitosan-a-rev",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Chitin-Chitosan - Isolation, Properties, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11670.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"83015",title:"Acute Changes in Lipoprotein-Associated Oxidative Stress",doi:"10.5772/intechopen.106489",signatures:"Ngoc-Anh Le",slug:"acute-changes-in-lipoprotein-associated-oxidative-stress",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:[{name:"Anh",surname:"Le"}],book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"83041",title:"Responses of Endoplasmic Reticulum to Plant Stress",doi:"10.5772/intechopen.106590",signatures:"Vishwa Jyoti Baruah, Bhaswati Sarmah, Manny Saluja and Elizabeth H. Mahood",slug:"responses-of-endoplasmic-reticulum-to-plant-stress",totalDownloads:3,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:null,institution:null},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"417317",title:"Mrs.",name:"Chiedza",middleName:null,surname:"Elvina Mashiri",slug:"chiedza-elvina-mashiri",fullName:"Chiedza Elvina Mashiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"352140",title:"Dr.",name:"Edina",middleName:null,surname:"Chandiwana",slug:"edina-chandiwana",fullName:"Edina Chandiwana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"342259",title:"B.Sc.",name:"Leonard",middleName:null,surname:"Mushunje",slug:"leonard-mushunje",fullName:"Leonard Mushunje",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"347042",title:"Mr.",name:"Maxwell",middleName:null,surname:"Mashasha",slug:"maxwell-mashasha",fullName:"Maxwell Mashasha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"2941",title:"Dr.",name:"Alberto J.",middleName:"Jorge",surname:"Rosales-Silva",slug:"alberto-j.-rosales-silva",fullName:"Alberto J. Rosales-Silva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"437913",title:"Dr.",name:"Guillermo",middleName:null,surname:"Urriolagoitia-Sosa",slug:"guillermo-urriolagoitia-sosa",fullName:"Guillermo Urriolagoitia-Sosa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"435126",title:"Prof.",name:"Joaquim",middleName:null,surname:"José de Castro Ferreira",slug:"joaquim-jose-de-castro-ferreira",fullName:"Joaquim José de Castro Ferreira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Aveiro",country:{name:"Portugal"}}},{id:"437899",title:"MSc.",name:"Miguel Angel",middleName:null,surname:"Ángel Castillo-Martínez",slug:"miguel-angel-angel-castillo-martinez",fullName:"Miguel Angel Ángel Castillo-Martínez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"289955",title:"Dr.",name:"Raja",middleName:null,surname:"Kishor Duggirala",slug:"raja-kishor-duggirala",fullName:"Raja Kishor Duggirala",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jawaharlal Nehru Technological University, Hyderabad",country:{name:"India"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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