Comparison of internet voting methods.
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\r\n\r\nThis work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634476 for project with acronym TREASURE. The content of this book reflects only the authors\' view and the European Union Agency is not responsible for any use that may be made of the information it contains.\r\n',isbn:"978-1-78985-408-4",printIsbn:"978-1-78985-407-7",pdfIsbn:"978-1-83962-011-9",doi:"10.5772/intechopen.83749",price:139,priceEur:155,priceUsd:179,slug:"european-local-pig-breeds-diversity-and-performance-a-study-of-project-treasure",numberOfPages:318,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"182fe65256f9a0bbc25b0b7576412b0e",bookSignature:"Marjeta Candek-Potokar and Rosa M. Nieto Linan",publishedDate:"February 6th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/9356.jpg",numberOfDownloads:22771,numberOfWosCitations:37,numberOfCrossrefCitations:35,numberOfCrossrefCitationsByBook:13,numberOfDimensionsCitations:60,numberOfDimensionsCitationsByBook:19,hasAltmetrics:1,numberOfTotalCitations:132,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"December 21st 2018",dateEndSecondStepPublish:"January 11th 2019",dateEndThirdStepPublish:"March 12th 2019",dateEndFourthStepPublish:"May 31st 2019",dateEndFifthStepPublish:"July 30th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:'
This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634476 for project with acronym TREASURE. The content of this book reflects only the authors\' view and the European Union Agency is not responsible for any use that may be made of the information it contains.
Many IoT systems consist of networks of sensors, the data from which is brought together and processed to give some desired results. The method used to connect the sensor to the Internet to enable the transfer of data is a design factor that needs to be considered early on. It is not the case that throwing a lot of bandwidth at the problem and processing the data together in a central location are the solution in most cases. The answer is do not “use 5G” for all systems!
There are many trade-offs involved in the specification of a radio system to be used for Internet of Things (IoT). The main trade-off is the bitrate and power trade-off. Sending messages at a high bitrate requires more power than that at a low bitrate. There is also a cost and bandwidth trade-off: high-bitrate solutions require a wide bandwidth which, generally, costs more than the low bandwidth. Finally, there is the often-overlooked fact that high bitrate solutions require high fidelity of the radio which means more receive power. This limits their use to applications where the separation of transmitters and receivers is small.
If cheap high-bitrate wireless communications are not available, what are the alternatives if the sensor needs high bandwidth (video cameras being the most obvious example)? The most obvious solution is to use a wired communication link. This may not be a viable option for many IoT solutions where the access to wired links is not available. The alternative is to use computing at the edge. By processing the signal at source—computing at the edge—we can decrease the bandwidth requirement, and, hence, we can use an alternative wireless communication solution.
First, we need to review digital communications as they pertain to wireless systems [1].
The wireless systems used in IoT applications will be digital systems. Although the world they are interfacing to is analogue, IoT systems will have a means of converting those analogue signals that come from the analogue world through sensors to digital signals. These digital signals will be processed ultimately in digital computers whether it be on the edge or in the cloud. It is, therefore, instructive to review digital communications systems.
Modern digital communications systems are complex with many layers that interact with each other. In this chapter we are only going to consider the lowest layer of the Open Systems Interconnection (OSI) model, the physical layer. Furthermore we are going to consider this layer from the perspective of the analogue and RF components of the system as they are the parts that drive a lot of the trade-offs for power consumption that will be a major driving factor in the selection of a radio system for IoT.
In order to understand the concepts of digital communications systems and even the hardware implementation of them, it is necessary to understand complex signaling. We will therefore review the concept of complex signaling and in-phase and quadrature (IQ) modulation.
A complex signal can be represented as a function of time using a complex exponential:
Expanding this exponential using Euler’s formula gives us this complex exponential function represented using trigonometric functions:
where
Graphically this can be represented by a vector from the origin with a magnitude of
If we introduce another vector with a negative value for the frequency:
we get a second vector that rotates in a clockwise direction at the same rate and tracing out the same circle. From the trigonometric identities:
we can see that if we sum the two vectors, the imaginary components are canceled and we are left with a real cosine with twice the amplitude of the vector components. This is illustrated in Figure 1.
Real cosine signal as a vector sum of two complex signals: A positive frequency signal rotating anti-clockwise and a negative frequency signal rotating clockwise.
By shifting the vectors by 90°, we get a sine with twice the amplitude of the vector components. This leads us to the basic formulae relating real sinusoidal functions to complex exponential functions:
From these equations real signals separated by 90° can be used to generate complex signals. Signals at 90° such as this are referred to as quadrature signals and the individual component signals as in-phase (
Using trigonometric identities, we can prove that:
What this tells us is that we can upconvert a baseband signal represented by:
with another signal, known as a local oscillator (LO) signal, represented by:
We can implement Eqs. (8)–(12) in circuitry using circuits that can multiply two real signals (circuits of this sort are known as mixers) by signals generated from an oscillator with phase shifters (LO generator) and some sort of circuit to sum the resultant outputs (usually done by summing currents). Such a circuit is called a quadrature modulator or quadrature mixer, and the figurative block diagram is shown in Figure 2 below with the local oscillator generation.
Quadrature upconverter with local oscillator (LO) and quadrature local oscillator generation.
The receive operation is just the reverse of the above—the RF signal is split into
Quadrature downconverter with local oscillator (LO) and quadrature local oscillator generation.
On top of all the other parts of the data transmission system is the need to encrypt the data. This needs to happen for the data itself and for any control channels. It is obviously important to encrypt the data itself as this is what has value for the user. However, if control channels aren’t encrypted, then an outside agent can read the control information and even take over the channel. This means it is necessary to encrypt control channels as well. Encryption will generally not add much to the overall size of data being sent and so does not affect the efficiency by sending more data. However, the computations involved in encryption do require extra power and so do lower efficiency.
When a radio receiver is moving, it goes through fades in signal strength due to two or more reflections of the signal interfering. This potentially leaves holes in the data stream, and these holes can lead to loss of information if related bits are sent together. In order to avoid this, the data bits can be separated so that consecutive bits are not sent together. An analogy would be a deck of cards arranged by suit. If four cards are taken together from a single place at random, it could mean, for instance, that the jack, queen, king, and ace of spades are all removed. If the pack is shuffled first, then the four cards taken from adjacent positions will not be related, and arranging the cards in suits, we should be able to spot the pattern even if individual cards are missing. Interleaving is like the shuffling of the pack in the example; however it is done in a controlled manner so that the data can be reconstructed.
Transmission of data will result in errors due to various random processes in the transmission. It is important to be able to a first level detect that an error has occurred and that the data is corrupted. It is much better to be able to correct errors that occur. The simplest method for correcting errors is to have the transmitter retransmit the data if an error is detected or no message acknowledging receipt of the data is received by the transmitter. This method is known as automatic repeat request (ARQ). An improved form of error correction, known as forward error correction, is achieved by adding extra bits to the data that is transmitted to enable both detection and correction of this data. Examples of error correction codes include convolutional codes that are added and processed on a bit-by-bit basis and Reed-Solomon codes or turbo codes that are added and processed on a block-by-block basis. If an error is detected in forward error correction that cannot be corrected, then ARQ can still be used and the data retransmitted. Adding error correction codes adds extra data to the transmission and so decreases the overall power efficiency of the system.
Transmitting data as a series of “0’s and 1’s” over the transmission medium would require a very wide bandwidth. The required bandwidth is a function of the rise and fall time of the data rather than the clock rate and is significantly higher than the clock rate of the data. To transmit over air for a wireless system, the data needs to be bandlimited first. A filter must be used to bandlimit the data, but the performance of the filter is important. The filter needs to be sharp enough to filter the data to fit in an assigned bandwidth (radio channel) but not destroy the higher frequencies of the data, and so it must have a sharp cut-off. The time domain performance (impulse response) of the filter is also important. If a signal is bandlimited in the frequency domain, then it tends to spread out in the time domain. This is obviously undesirable with a digital signal as one data symbol would interfere with subsequent symbols. There are two approaches to the impulse response requirement:
Allow inter-symbol interference to happen, and correct or allow for it in the receiver. In this case the receiver will contain an equalizer to provide an inverse filter to the original filter (and any filtering from the channel as well). Alternatively, the receiver may implement the Viterbi algorithm to decode the data signal.
Use a filtering scheme; a root-raised cosine (RRC) filter is common, that has nulls at the subsequent symbols. In this case the filter on the transmit is matched with an identical filter in the receiver. In the case of an RRC filter, the impulse is a sinc function which naturally has nulls at integer time intervals. A data signal passed through such a filter will look like a sequence of overlapping sinc functions with the nulls of the previous sinc functions occurring at the peaks of the subsequent ones. This is illustrated in Figure 4.
A filter with a sinc impulse response being fed the bit sequence (1011). The filter latency means that the signals will be delayed with respect to the input.
To transfer a digital bit stream over an analogue channel, it is necessary to use some form of modulation. In modulation, a periodic signal, carrier signal, has its frequency, its amplitude, or phase or both changed—modulated—by a second signal. For digital modulation, this second signal is a filtered version of the digital bit stream. Modulation schemes can be divided into many different groupings—phase modulation, frequency modulation, and amplitude modulation—but for the front end, the grouping that matters is non-linear also known as constant amplitude modulation (AM) and linear modulation. The bit stream is broken up into symbols. Each symbol can be one, two, three, or more bits long. These symbols are used to modulate the carrier. To send a data stream over a link with a given bandwidth, in general a symbol with more bits is needed. This will mean that both amplitude and phase will need to be modulated and the system will be more susceptible to errors.
The simplest modulation to visualize is amplitude modulation (AM). The amplitude of the carrier wave is modulated by the modulating signal. We are familiar with AM radio where the signal doing the modulation is an analogue signal. This modulation can be demodulated by using a simple diode, and in the simplest receivers, this diode was made from a crystal (lead sulphide) with a “cat’s whisker’ touching it leading to the term “cat’s whisker radio” or “crystal radio” [2]. For digital bit-streams, “On–off keying” is the simplest form of amplitude modulation and is known as amplitude shift keying (ASK). In practice the carrier is usually not switched on and off as this causes spurious signals around the transition but is switched between two amplitudes. A signal that is switched sharply between two different amplitudes is wideband, so a filtered signal is used leading to a smooth transition between the two signal levels (Figure 5).
Amplitude shift keying (ASK) with two levels (no filtering) modulated by the sequence [1011].
In frequency modulation (FM), the frequency of the carrier is modulated. Frequency modulation is the FM in FM radio, and in this case the modulating signal is analogue [3]. The simplest example of FM use as a digital modulation would be using on–off keying where the carrier is switched between two frequencies. This is known as frequency shift keying (FSK). If more than two frequencies are used, it is possible to send more than one bit at a time—for instance, three bits would require eight different frequencies (Figure 6).
Frequency shift keying (FSK) with two levels (no filtering) modulated by the sequence (1011).
Again, to limit the bandwidth, the input signal is filtered, and the transition passes through the intermediate frequencies. A typical version of filtered FSK is GFSK which uses a Gaussian filter before to limit the bandwidth—GFSK is used in many radio systems, Bluetooth being a good example. An efficient form of frequency modulation is minimum shift keying (MSK). In MSK, the two frequencies used differ by half the bitrate, and this gives a very efficient modulation with a modulation index of 0.5. If Gaussian filtering is used to limit the bandwidth with MSK, the resulting modulation is known as GMSK, and this is the modulation scheme used in GSM. In FM radios (digital and analogue), the amplitude of the signal is not important, and so the radio is much more robust and tolerant of signal fading. Therefore, FM radio was the preferred medium for broadcast radio before the arrival of digital radio. However, FM requires a more complicated receiver than AM. As the amplitude is not important—it is a non-linear modulation—the transmitter can be simplified vs. a transmitter used for modulations where the amplitude varies (linear modulations).
In phase modulation (PM) schemes, the phase of the carrier is varied. Again, on–off keying can be used to vary the phase, such a modulation being known as phase shift keying (PSK). The simplest form is binary phase shift keying (BPSK) where only one bit is used, and the phase is varied by 180° to represent a binary “0” or “1”. In theory, BPSK, like all pure phase modulations, is a constant envelope modulation (there is no change in the amplitude), but that would require an infinite bandwidth to accommodate an instantaneous 180° phase shift. In practice a BPSK where the bandwidth is limited will have amplitude modulation associated with it. Both unfiltered and filtered BPSK are shown in Figure 7. BPSK is the modulation used in Zigbee for the low band.
Binary phase shift keying (BPSK). The left-hand side is without filtering on the bit stream which has shown modulating a low-frequency signal to make the transitions clearer; the right-hand side is with filtering of the data stream but with a higher frequency to make the resulting amplitude modulation clearer.
If a two-bit symbol is to be transmitted, then four phases must be used each 90° apart; such a modulation is known as quadrature phase shift keying (QPSK), and variants are used in many commercial radio systems. For a three-bit symbol, eight phases are needed each 45° apart, and this system is known as 8PSK. The constellation points for QPSK and 8PSK are shown in Figure 8. More bits can be added to the symbol, and the number of phases increased for each extra bit by a factor of two, but this rapidly becomes impractical as the tolerance of error decreases as each extra bit decreases the distance between phases by a factor of two. QPSK, 8PSK, and higher orders of PSK have an amplitude component and require linear transmitters. This also means that the power amplifier needs to be linear and so is less efficient than the switching power amplifiers used in non-linear modulations like GMSK or GFSK.
The QPSK and 8PSK constellation points plotted in the complex domain.
For amplitude modulation and frequency modulation systems, it is possible to consider only one scalar quantity (amplitude or frequency). For phase-modulated systems, we must look at amplitude and phase, and that requires us to look at a complex representation of the signal at baseband (real, imaginary). We can map the signal out on the complex plane and see what it looks like. For a QPSK signal, the four decision points are 90° apart. We can easily visualize the points (1,0), (0,1), (−1,0), and (0, −1). However, as long as the four points are 90° apart, the location of the initial point can be at any random phase around the circle, and so a 45° phase shift also gives valid points at (√2, √2), (−√2, √2), (−√2, −√2), and (√2, −√2). This arrangement always includes a path that passes through the origin—in other words the amplitude goes to zero—and this is bad for the power amplifier as it must be sufficiently linear to be able to handle this change through zero amplitude.
One solution to the need to pass through zero is to offset one of the in-phase and quadrature bit streams by half a clock cycle ensuring that the code points never change by more than 90°, so the modulation will never pass through zero. This scheme is known as offset QPSK (OQPSK). Another solution is to rotate the constellation of points by 45° at each symbol so that there is no path through the origin and the amplitude never goes to zero. This is known as π/4 QPSK. Both these schemes are used in radio standards to simplify the requirements for the power amplifier (PA). The constellation diagrams of QPSK and π/4 QPSK are shown in Figure 9.
QPSK and π/4 QPSK constellation diagrams. Note that the π/4 QPSK constellation does not pass through the origin simplifying the design of the PA.
The final sort of modulation we will consider is quadrature amplitude modulation (QAM). QAM modulates both the phase and the amplitude. Generally, it uses points that are in a square centred on the origin, so QPSK is actually a form of QAM. This means that powers of two that are also square numbers are preferred numbers of constellation points: 4 QAM (QPSK), 16 QAM, 64 QAM, 256 QAM, 1024 QAM, etc. A constellation diagram for a 16 QAM implementation is shown in Figure 10.
Constellation points for 16 QAM modulation.
QAM can support high data rates with a relatively small bandwidth, and this makes it desirable in applications where a high bitrate is desired. However, because the spacing between constellation points is less than in other modulations and decreases as more points are added, QAM requires more precision in the transmit architecture and is less robust on the receive side to noise and fading. On the transmit side, the transmitter and the power amplifier need to be very linear. On the receive side, the whole receiver needs a much wider dynamic range than other modulations.
When sharing a communications medium, the users need to be allowed access to the medium in a controlled manner. There are several techniques that can be used to control access to the medium. Usually a combination of several of these methods is needed to get a system to work well.
The first, and perhaps most obvious, is spatial separation known as spatial division multiple access (SDMA). This is the principle used in the cellular network where an area is separated into cells with channel allocation such that neighboring cells do not share the same channels but channels are reused in cells that are sufficient far apart that they will not interfere with another.
The next technique is to separate the channels by frequency using a technique called frequency division multiple access (FDMA). We are all familiar with this from AM and FM radio stations as well as terrestrial broadcast television. In fact, all radios use this technique in some form or another; as radio signals of a certain type are restricted to certain bands, the access to most is controlled by a government agency. Within a radio band, users can be assigned channels that are also of different frequencies and are a sub-band of the overall radio band assigned to that system.
The next technique is time division multiple access (TDMA). In this case the resource is split into units of time generally called slots. A user is allocated a slot to transmit on and is quiet in other slots. There will generally be a matching slot (or slots) on the receive side to receive transmissions. TDMA is good for transmissions that are bursty in nature which many IoT applications are. TDMA is used in the GSM system.
The final technique is code division multiple access (CDMA). Each user is allocated a code that is unique to them and mathematically orthogonal to other user codes. The data stream is multiplied with a much faster version of the code and transmitted. On the receive side, the receiver uses the same code and again multiplies the incoming data by that code to decode the message. The principle is simple, but the actual implementation is complex because of the need to time align the code with the received signal and the presence of reflected copies of the signal.
Orthogonal frequency division multiplexing (OFDM) is a technique mainly used to transmit wideband data. OFDM has a number of advantages for the transmission of wideband data which is why it is used in all new wideband systems:
It is robust against narrow band interference from other radios.
It is robust against fading.
It deals with multi-path easily.
However, is also has disadvantages:
It is sensitive to Doppler shift.
It has a high peak-to-average ratio (PAR) which requires a linear power amplifier and a lot of current.
For IoT systems that aren’t designed to be particularly mobile, the sensitivity to Doppler shift is probably not an issue. However the inefficiency of a good linear power amplifier will be a significant issue in systems where battery current is premium.
In an OFDM system, the radio band is split into a number of sub-bands with sub-carriers which are modulated separately. Each sub-carrier needs to be orthogonal to the others which gives the relationship:
where
where
OFDM channel structure.
Within each sub-band, the sub-carrier is modulated just as it would be in a single carrier system. QAM-based modulations are common starting with QPSK, although 802.11a allowed BPSK, and increasing the symbol size and modulation as the communications channel quality improves.
Usually the centre sub-carrier of the overall bandwidth is not modulated. This assists on in the receiver where it converts down to DC. Modern receivers are generally what is known as direct downconversion receivers, and the control of DC offsets is an issue. With no useful signal around DC, the DC offset can be eliminated using simple filtering schemes.
A variant of OFDM, orthogonal frequency division multiple access (OFDMA), shares the band between users rather than dedicating the whole band to a single user. This is done by designating each user a group of sub-carriers. It is used on the downlink of the cellular standards of the Long Term Evolution (LTE) family and 5G.
A variant of OFDM, single carrier frequency division multiple access (SC-FDMA), is used in the cellular standards on the uplink. In SC-FDMA, the bit stream is processed in a manner similar to OFDMA, but the parallel streams are then serialized to give a single carrier modulation. This gives a signal with much less PAR which requires a less linear power amplifier and transmit section and so saves power. As user equipment is battery driven and therefore sensitive to power consumption, this is necessary for the quality of service it can deliver customers.
How a radio system handles the relationship between transmit and receive has a large impact on the design of the radio front end and the power consumption of the overall radio. It is possible to transmit while receiving, and a lot of modern radio systems have this capability. These systems are known as full-duplex systems. Obviously, if they are to transmit while receiving, they cannot use the same frequency; otherwise they block themselves. (The exception here is radar which we will cover later.) The systems that do not permit transmission at the same time as reception are called half-duplex systems and are significantly simpler and more power efficient.
There are two approaches to duplexing: frequency division duplex (FDD) and time division duplex (TDD). FDD is the only approach that allows for full-duplex operation as the transmitter and receiver are operating at different frequencies. Usually this requires a front-end filter called a duplexing filter or duplexer that filters the transmit out on the receive path and filters transmit noise in the receive band out on the transmit path. Cellular radios usually separate the transmit and receive bands and so are capable of full-duplex operation even though some of the earlier standards did not call for it.
TDD is a half-duplex technique that is used a lot in connectivity radios (e.g. WiFi, Bluetooth) and is specified for some cellular radio standards but is not as common there. A TDD radio uses the same frequency for transmit and receive and will transmit and then switch to receive to listen for any reply.
Figure 12 is a block diagram showing the structure of a constant envelope transmitter. As the data is only coded in the phase, the amplitude contains no information. It is still necessary to control the amplitude in many radio systems to ensure that the signal received by the base station is not too large or too small. However, this amplitude control only needs to be accurate enough to ensure the signal is within a few dB of target and can be relaxed compared to a system that uses linear modulation.
Constant envelope transmit employing a PLL.
With no requirement to provide modulation on the amplitude, only a circuit that modulates the phase is required, and a PLL is the best circuit for the job. The first transmitters of this type were introduced for GSM and used offset-loop PLLs to be compatible with the Cartesian baseband circuit outputs available at the time. These were quickly replaced by what are known as fractional N (frac-N) frequency synthesizers. In a frac-N frequency synthesizer, the divider is controlled by a sigma-delta modulator, and the divide ratio is constantly updated between integer values allowing the effective average ratio to be a fraction of the nominal integer divide ratio. This operation is carried out in the digital domain making circuit design easier.
The noise from the PLL and associated circuits is filtered by the PLL filter. This means that the noise far away from the carrier is dominated by the voltage-controlled oscillator (VCO), divider, and power amplifier (PA) noise. As noise away for the carrier is important in radio systems, this is a big advantage for these constant envelope transmitters. It generally means that the filtering at the output of the PA can be a simple harmonic trap filtering—filters out harmonics of the transmit signal—and does not need to filter close to the transmit signal. Harmonic trap filters can be implemented using standard passive components (inductors and capacitors) not specialized components (SAW, BAW, or FBAR filters), and these filters will generally have lower loss (meaning the overall transmitter is more efficient).
The design of the VCO is critical. It needs to have a very low noise profile as this noise will dominate the noise of the transmitter, and it needs to be able to drive the output well. Following the VCO is a divider. This is usually a divide by two dividers, so the VCO frequency is set at twice the desired output frequency. The use of a frequency of twice the transmit frequency is to stop feedback from the PA causing the VCO to shift off frequency. This effect is known as pulling and happens if the output signal is at the same frequency as the VCO frequency as the VCO will injection lock to the PA output signal. In some cases, even with a VCO being run at twice the transmit frequency, the VCO can still be pulled if the PA produces lots of second harmonic distortion. In this case a VCO frequency of four times the transmit frequency can be used with cascaded dividers that divide by two each. Running the VCO at twice or four times the transmit frequency obviously has power implications because the transistors will have less gain at higher frequencies. This is an unavoidable trade-off in these designs.
Figure 13 is a simplified block diagram of a typical transmitter used for cellular and connectivity solutions in smartphones. This sort of transmitter is known by many names, but
Cartesian upconverter-based transmit for linear modulations with a PLL to control the local oscillator. Modulation is done on the digital domain giving digital
It is obvious that this transmitter is a lot more complex than the constant envelope transmitter. In fact, the Cartesian transmitter uses most of the components of the constant envelope transmitter just to generate a constant local oscillator (LO) signal. The complexity not only means an increase in cost but also an increase in power consumption.
The linear modulation signal has both amplitude and phase components, and so the signal chain needs to be linear. This means it needs to have a constant DC bias current flowing and so is less efficient than a non-linear equivalent that can just operate as a digital logic gate switching between states. This inefficiency shows up particularly in the PA which can have half the efficiency of its non-linear counterpart.
One extra effect to consider for a transmitter suitable for linear modulations is the noise. It is a general rule that any component added to a system will add noise. Whether this added noise is large enough to affect the overall signal to noise of the system is somewhat a matter of design. In the case of the Cartesian transmitter, the signal path adds a substantial amount of noise to the signal being transmitted. In past the signal was usually cleaned up by adding a filter between the transmitter and the PA. This was easily achieved as the transmitter and the PA are usually on separate integrated circuits even now, and so the signal had to pass through the main circuit board to which a filter could be easily added. However, filters are expensive, and as the number of bands increased, the transmitter had to serve more bands which meant more filters, and some form of isolation was needed for unused bands. The filter was eliminated by cutting the noise of the transmit chain itself.
The VCO for the LO needs to be at a different frequencies from the transmit for the same reason as the constant envelope transmitter, namely, VCO pulling. If the VCO is not being operated at some integers multiple of the desired frequency, then extra circuits are needed to generate the desired frequency. The VCO can operate at twice the desired frequency, but if possible, four times makes more sense as it is easier to generate LO signals that are exactly 90° apart. Having LO in-phase and quadrature signals that are exactly 90° apart helps keep the number of errors down in the overall transmitter.
Figure 14 shows a simplified receiver. It looks somewhat like a Cartesian transmitter in reverse. The PA is replaced by a low noise amplifier (LNA), and again two LO signals that are 90° apart are used to downconvert to baseband. This scheme is called direct downconversion. In the past, heterodyne receivers were used, and the signal was converted down through one or more intermediate frequencies (IFs) before being brought down to the baseband. Consumer radio receivers, including those for the cellphone network where more performance is needed, are all direct downconversion receivers.
Typical architecture for a direct downconversion receiver.
There are no pulling issues as such in the receiver, so the VCO for the LO can be at the same frequency as the receive signal, but running at twice or four times the frequency makes the generation of the quadrature components easier using a divided down VCO. For a full-duplex radio, it is possible to share the VCO between the receive and the transmit, but this requires a method to derive the transmit frequency and receive frequency from the same source. Two synthesizers can be used, but care must be taken to ensure they do not talk to each other.
On the receive side, as on the transmit side, most of the power consumption occurs in the RF blocks. These are the LNA, mixer, and LO buffer. The baseband filtering will not consume as much power, but the power consumption in the baseband filters is a function of the bandwidth of the signal: wider bandwidth leads to more power consumption. Having a narrower bandwidth not only lowers the power requirements for the filtering but also allows for more resolution in the ADC as it can run at a lower frequency than a wider bandwidth radio, and resolution and bandwidth tend to have a reciprocal relationship. With higher resolution on the ADC, it is possible to move more of the filtering and gain functions into the digital which makes the design easier, smaller, and often lower power.
Figure 15 shows the radio front end for a half-duplex radio (the transmit and receive never operate at the same time) and a full-duplex radio. Both use frequency division duplexing (as would be seen in a cellular radio system). Many elements overlap with the previous figures showing transmit and receive structures. This is so that you can see how everything fits together. In the cellular world, the front end started out as discrete components. Later, the LNAs were integrated into the transceiver chips, but the other RF components were kept separate and integrated into their own modules. The recent trend has been to take the LNA out of the transceiver chip and integrate it back with the RF front end in a module.
Half-duplex and full-duplex front ends.
In the half-duplex radio, the filters can be relatively loose and made using standard passive components, so they tend to have less loss and can even be integrated with the power amplifier easily. Both the PA and LNA require matching circuits. For the PA the match is a power match and can often be combined with the trap filtering required. For the LNA a noise match is needed. The switch loss needs to be added to the filter loss on the transmit, but generally, the overall loss can be less than 2 dB. A receive channel filter is optional, and, in fact, modern, well-designed receivers do not need it, and so on the receive side, the front end can have less loss, be cheaper, and be relatively easy to integrate.
For a full-duplex radio, the duplexer needs to reject the transmit as much as possible on the receive side but also reject the transmit noise which lies in the receive band. The transmit noise in the receive band will be the limiting factor on the receiver performance. Duplexers are made using special processes—SAW, BAW, or FBAR—and add a significant cost to the front end. They tend to have a loss of 3 dB or more in the transmit path which means half the power put out by the PA is lost in the output network which directly translates to a need for a bigger battery.
The block diagram for a TDD radio front end is shown in Figure 16. Duplexing is done using time separation of transmit and receive, and the same frequency band is used for both. This means no duplexer is needed and the filtering can be handled by the same band filter for both transmit and receive. In some applications this filter can be omitted, but in applications where performance out of band is important (some of the TDD versions of the cellular standards and WiFi, for instance), it is often needed.
TDD front end with band filtering.
There are five choices that directly affect the amount of current needed in the RF front end for the transmit operation:
Frequency of the transmitter
Bandwidth of the signal
Number of radio bands supported
Type of modulation—linear or non-linear
Full-duplex or half-duplex
Output power
For the receiver, the list looks similar:
Frequency of the receiver
Bandwidth of the signal
Type of modulation—dynamic range required
Full-duplex or half-duplex
Presence of interfering signals
We will look at each individually.
The frequency that the transmitter and receiver work at determines the current required. The higher the frequency, the more current are required as the transistors have less gain at higher frequencies. This immediately constrains the bandwidth of communication that can be handled as the bandwidth available increases with increase in frequency.
Another advantage of going low in frequency is that the signal will suffer less loss and can travel through obstacles better. If an IoT system is needed to operate throughout a building including traveling through walls, then it is better to operate at a lower frequency than at a higher one. This is readily seen in WiFi where the 2.4 GHz signal will be found to have more reach than the 5 GHz signal from a dual band router.
One disadvantage of using a low frequency is that the antenna size increases. If the system requires many antennas (as a MIMO system does), then this can be problematic.
The bandwidth of the signal determines the noise level of the system as white noise is being integrated over the bandwidth. As the bandwidth increases, the noise level increases with it, so to maintain the same signal-to-noise ratio, the signal must be increased which increases the current. Also, at a given bias current, the gain-bandwidth product of transistors is fixed. As bandwidth increases, the bias current of transistors needs to increase to increase the gain-bandwidth product and maintain the gain at the same level.
Increasing the number of bands requires that some mechanism be found to stop all the circuitry for the radio bands that are not being used interfering with the transmission in the band that is being used. The usual method used to isolate bands is to incorporate a “band switch” in between the antenna and the output of each band. This switch is turned on when the band is to be used. However, when the power amplifiers for the radios are all on the same die, coupling increases, and the harmonics reaching the switch may be high enough that the switch does not have enough isolation. In the case where the switches are all on one die (the cheapest option as they can share circuitry), then the isolation can be further reduced by coupling.
The biggest issue with supporting a large number of bands is the necessity of providing filtering on these bands, especially in the case of full-duplex radios. As the number of bands and, therefore, filters increases, the cost increases. This is likely to lead to IoT solutions needing a separate RF front end for each geography covered so as to keep the number of bands manageable.
The transmitter for non-linear modulation offers significant savings in power and complexity over a transmitter for linear modulation. A frequency synthesizer is all that is needed for most non-linear modulations, whereas a linear modulation would need the frequency synthesizer and a linear upconversion transmit. Finally, the power amplifier for a non-linear modulation can be a switching power amplifier; a linear modulation needs a linear power amplifier which is not as efficient.
Linear modulations offer the prospect of much higher bitrates, but this comes at the expense of power consumption. If you are trying to run at high data rates, then you will have to accept that your system will be power hungry.
On the receive side, the same type of receiver RF and analogue circuits are used for both linear and non-linear modulations, and so there is no difference seen between these types of modulation. However, the dynamic range required for the modulation has a large effect on the current requirements of the receiver. In general, a switch to higher orders of QAM means that a higher signal-to-noise ratio is required of the received signal than modulations like QPSK or GMSK, and so this means a wider dynamic range is required in the overall receiver.
A full-duplex radio offers the prospect of higher bitrates on both the transmit and receive because both are working at the same time. Unfortunately, this means that more spectrum must be used to cover the transmit and the receive functions. A duplexer is necessary in this case, and this not only adds cost and complicates the front end design but also increases the loss in the transmit path. This increased loss leads to a lower efficiency for the transmitter and higher current draw for the same output power. On the receive side, the filtering must remove the large transmit signal, and this tends to lead to a larger loss for the desired signal as well. This loss must be compensated for with a lower noise figure in the receiver circuits, and this requires more current.
Half-duplex radio front ends are far simpler and have less loss. Most IoT data traffic is low data rate or bursty in nature, and this sort of traffic is well served by half-duplex radios. It should also be noted that the radio systems that use the ISM frequencies are half-duplex by necessity. As many IoT systems will make use of these radio systems, they are inherently half-duplex.
Power is the product of current and voltage. Increasing the power requirements while keeping the voltage the same will require more current. For battery-powered devices, the voltage is fixed by the battery chemistry and by the reliability constraints of the integrated circuits being used, and so if more output power is required, then more current will need to be taken from the battery.
Large interfering signals on the receive side will affect the radio receiver by limiting the dynamic range of the receiver. If the signal is also large, then this may not be a problem. However if the desired signal is a lot smaller than the interfering signals, then the dynamic range of the receiver needs to be increased to receive both the interfering signal and the desired signal. In order to increase the dynamic range, it is necessary to increase the current in the circuits.
The most widely used and pervasive radio systems are cellular radio systems. Originally just an extension of the telephone service, cellular radio systems have grown into much more enabling data download and upload and giving access to the Internet virtually anywhere. For IoT applications that need mobility or access to the Internet from remote locations, a cellular radio will be the first consideration, and so we need to consider the alternatives. It should be noted that the need to pay royalties for IP included in the cellular specifications may make cellular a more expensive option than some of the other radios.
Cellular radios work on the principle of multiple transmitters and receivers separated into cells (hence the name), each controlling the communication with end users in the cell. The system works based on spatial separation: adjacent cells use a different set of frequencies, but cells sufficiently far away can re-use the same set of frequencies. Hand-off of mobile users is an important function of a cellular system, and a lot of resources are assigned to this function. A cellular network of cells each with its own base station is shown in Figure 17.
A cellular radio layout with a base station at the centre of every cell serving that cell.
Cellular radio systems are so-called because the coverage area is broken up into adjacent cells, each covered by a single wireless communication receiving and transmitting station called a base station. The original cellular radio systems were analogue and did not use digital modulation or any of the other techniques used in digital communications systems. We will not discuss those as they have been superseded and are of no relevance to IoT.
The first digital systems were the so-called 2G systems—analogue-based systems being 1G. There were multiple 2G systems deployed around the world—IS-136 (also known as TDMA) and IS-95 (generally called CDMA) in the USA and some other countries, PDC in Japan, and GSM throughout Europe and later most of the rest of the world.
The original 2G systems were circuit switched and served the voice market. Later, GPRS, a packet switched network, was added to the GSM system and allowed data communications to happen over the original GRPS network. Enhanced Data Rates for GSM Evolution (EDGE) was an upgrade of GPRS with a higher data rate. Some people used the names 2.5G to describe GPRS and 2.75G for EDGE.
High-speed data communications came with the 3G networks. All systems for 3G communications were based on CDMA technology. The GSM world migrated to Universal Mobile Telephone System (UMTS), while IS-95 CDMA networks migrated to CDMA2000. Further enhancements to the UMTS system— high-speed downlink packet access (HSDPA), high-speed uplink packet access (HSUPA), and high-speed packet access (HSPA) with further evolved versions adding a “+” (HSDPA+, HSUPA+, HSPA+)—allowed even higher data rates. The IS-95-based networks were able to upgrade to a new standard called evolution data optimized (EVDO). Following the naming convention adopted for higher-speed 2G networks, these enhancements were called 3.5G and 3.75G by some.
The GSM-based and IS-95 CDMA-based worlds came together with Long Term Evolution (LTE). For the first time, the world had a single cellular standard. This was named 4G by the marketing folks even though it did not meet the requirements for a next generation system as defined by the International Telecommunication Union (ITU) in its International Mobile Telecommunications Advanced (IMT Advanced) specification. In particular, while LTE is able to meet speeds of 100 MBps in the downlink and 50 MBps in the uplink, the IMT Advanced specification calls for 100 MBps to a fast moving vehicle and 1 GBps to a stationary device. The modulation in LTE changed to orthogonal frequency-division multiple access (OFDMA) on the downlink and single carrier frequency domain multiple access (SC-FDMA) on the uplink.
An enhanced version of LTE—LTE Advanced—does meet the requirements for a next generation system as defined by the International Telecommunication Union (ITU) in its International Mobile Telecommunications Advanced (IMT Advanced) specification.
The latest cellular standard, 5G, is being deployed now. With 5G, data rates have been increased up to a promise of 2 Gbps for some networks in ideal circumstances and latencies of 4 ms or less, with 1 ms being an oft-quoted target.
The work to define a European cellular system started in 1983 under the Groupe Spécial Mobile (GSM) committee. This acronym later came to stand for Global System for Mobile Communications. The first systems were deployed in 1991. Over the years GSM and its packet radio version general packet radio service (GPRS) became the standard for cellular coverage. For IoT systems that need to work worldwide or in rural areas, GSM, or its IoT version extended coverage GSM IoT (EC-GSM-IoT), is still the system to use as it is the only one that is likely to have coverage.
GSM uses a combination of frequency division duplex (FDD), frequency division multiple access (FDMA), and time division multiple access (TDMA) to allow multiple users to use the system [4]. The transmit and receive frequency bands are separated (on the user side, the transmit is the lower-frequency band, and the receive is the higher-frequency band), with equal bandwidth dedicated to both. Each band is spit into channels of 200 kHz. Within a channel, TDMA is used to control access. Each channel is divided into frames of 4.615 ms each, and each frame is divided into eight time slots (or bursts) that are allocated between users. Users can use up to four of the eight slots in most systems, although there are higher-order specifications where more time slots are available, they tend not to be used. The maximum theoretically achievable bitrate is 114 kbps, but deployed systems do not get close to this limit.
The modulation used in GSM and GPRS is GMSK and is, therefore, a constant envelope modulation which lightens the requirements on the transmitter and power amplifier. Although there are classes of GSM that can be full-duplex, most implementations are half-duplex, and this removes the need for a duplexer. The combination of a constant envelope modulation and no requirement for a duplexer makes GSM transmitters very efficient.
The low bands for GSM allow for a transmission of up to 2 W (33 dBm) in the low band and 1 Watt (30 dBm) in the high band. The high output power with a timing advance specification in GSM that allows operation out to 35 km means that GSM is the ideal choice for operation in rural environments where, quite apart from the fact that it may be the only system available, the base stations will tend to be spread further apart.
It should also be noted that GSM has the capability to handle text messages in the form of short message service (SMS) which can be used to send small amounts of data. This capability could be useful for some IoT systems where only a small amount of data is typically sent. Each text message is 140 bytes although extensions allow more data to be sent by breaking that data up across multiple messages.
Enhanced Data Rates for GSM Evolution (EDGE) as the name implies is an extension of GSM and GPRS to further increase the maximum possible data rate [4]. The highest theoretical data rate is over 384 kbps, the threshold for a 3G system, but EDGE networks generally do not get near this number.
EDGE generally fits on top of the GSM system: it uses the same channel bandwidth as GSM (200 kHz) and similar filtering (Gaussian) and when the channel conditions are not good will use GMSK modulation. However, with the best conditions, it can use a new modulation: 8PSK with a 3π/4 shift between symbols to avoid the zero crossing. The symbol for this new modulation is three bits long, and so, theoretically, three times the data can be sent over the channel. The 8PSK modulation has an amplitude component, and the strict adjacent channel requirements inherited from GSM mean that, unfortunately, the power amplifiers and transmit chain used in EDGE have relatively low efficiencies (higher teens percent than over 50% for GSM). This meant that there was a relatively large market for a hybrid solution with full EDGE capability on the downlink but only GPRS modulation using GSM components on the uplink to save on battery life. EDGE networks have mostly been superseded by 3G and LTE networks, and so it has little relevancy for IoT.
Extended coverage GSM IoT (EC-GSM-IoT) is an extension to the GSM specification to allow it to work for IoT devices. The system was specified in such a way that the base station could be upgraded in software. As no hardware changes are possible, there are no changes to the modulation. Devices that support EC-GSM-IoT can be GMSK only or GMSK and 8PSK capable.
The Universal Mobile Telecommunications System (UMTS) often known as Wideband-CDMA is the first true 3G system. The initial specification is known as R99 (Release 99) and is controlled by an organization known as 3rd Generation Partnership Project (3GPP) [5]. The GSM specification [4] was also rolled into 3GPP and is controlled by the 3GPP.
Several changes were introduced including the replacement of the TDMA used in GSM and EDGE with a code division multiple access (CDMA) to enable sharing of the medium. The bandwidth of the channel moved from 200 kHz to 5 MHz. The filtering was changed from a Gaussian filter to an approximation to a root raised cosine (RRC) improving the inter-symbol interference characteristics. The modulation used on the downlink is QPSK and OQPSK is used on the uplink. This means that the modulation has an amplitude content, but the adjacent channel requirements in UMTS are not as stringent as in EDGE, and therefore the PA needs less linearity and can be more efficient, with efficiencies over 40% on the uplink being common.
The system is full-duplex, meaning a duplexing filter (duplexer) is needed. This filter has more loss than the simple harmonic trap filtering that can be used in GSM because it is a half-duplex system and adds to the transmit losses of UMTS. Baseband processing in the system changed completely with the move to CDMA, and a lot more processing was added. Overall power consumption went up considerably with UMTS. Smaller geometries for the chips and new techniques have brought that power consumption down, but it is still higher than what can be achieved for a GSM system if that GSM system is optimized.
Later the air interface was changed and new modes added—high-speed downlink packet access (HSDPA), high-speed downlink packet access (HSUPA), and high-speed packet access (HSPA). There were many changes including changes to modulation available where the channel could support a higher data rate. In HSDPA 16 QAM was added to the downlink. Later a further enhancement was added in Release 7 of the 3GPP specification and was known as evolved high-speed packet access (HSPA+) which used up to 64 QAM modulation and promised theoretical speeds of 337 Mbps in the downlink and 34 Mbps in the uplink.
As a legacy system, there may be some IoT applications that make use of the 3G standards, but in many parts of the world, 3G has been superseded by Long Term Evolution (LTE) systems. For rural applications, GSM remains the only system with significant coverage throughout the developed and developing world.
Long Term Evolution (LTE) is the standard that most networks, certainly in cities, are operating on. It is usually called 4G to differentiate it from 3G even though it does not meet the criteria for 4G as given by the ITU. LTE has theoretical data rates up to 300 Mbps on the downlink and 75 Mbps on the uplink [6]. The system is designed to operate out to 100 km with what is defined as acceptable performance and so could be used in a rural setting. The bandwidths used for the signal are flexible and vary between 1.4 and 20 MHz. LTE is available in frequency division duplex (FDD) and time division duplex flavors. With the addition of carrier aggregation, even wider bandwidths are effectively available at the expense of complexity in the specification, design, and testing.
The modulation was changed to orthogonal frequency division multiple access (OFDMA) for the downlink and single carrier frequency division multiple access for the uplink to limit the peak-to-average ratio (PAR) so that the power amplifier does not have to operate backed off by a lot and so conserving power. With special filters and power supply control, the power consumption of an LTE smartphone is reasonable in an urban context with base stations spaced relatively closely.
The change to OFDMA increased the spectral efficiency of LTE vs. UMTS by a factor of up to five times. As spectrum must be bought from the government for substantial fees, this is obviously attractive for cellular carriers. We should bear in mind, however, that spectral efficiency may not be factor in an IoT application.
The LTE channel is divided by time and frequency into units called resource blocks (RB). Each RB is 0.5 ms long and 180 kHz wide made up of 12 15 kHz sub-carriers. A user can be assigned a minimum of 2 RB in a 1 ms sub-slot. The more resource blocks a user is assigned, the higher the data rate is available to that user. The number of resource blocks available is dependent on the channel bandwidth and varies from 6 for a 1.4 MHz bandwidth up to 100 for a 20 MHz bandwidth. As can be seen, as each RB is 180 kHz, the 1.4 MHz bandwidth has 1.08 MHz of used bandwidth and 160 kHz of guard band on each side. For the 20 MHz case, the guard band would be 1 MHz on each side.
While the whole world is covered by four frequency bands for GSM (two in most of the world and two in the Americas), LTE requires a much larger number of bands to support worldwide operation. This requires a large number of filters and switches as well as power amplifiers and puts the cost up substantially.
Long Term Evolution Machine (LTE-M)-type communication and Narrow Band Internet of Things (NB-IoT) are low-power wide area network (LPWAN) protocols from the 3GPP as an extension of LTE that allows the cellular network to be used as an LPWAN. LTE-M was developed as a result of a realization that the LTE as it stood was not suitable for IoT and machine communications. The LTE-M targets are low device cost, long battery life, ability to support many devices in each cell, and deep coverage. LTE-M aims to achieve these objectives by allowing half-duplex operation, going to a single antenna only, adding a lower power class, supporting a lower data rate, and operating at a lower bandwidth.
There are two sorts of LTE-M defined in the 3GPP specifications—LTE-CAT-M1 and LTE-CAT-M2—but LTE-CAT-M1 is the most commonly deployed. LTE CAT-M1 uses a 1.4 MHz channel—the smallest available in the LTE specification. The system can support half-duplex and full-duplex operation. It is a single-antenna system (does not support receive diversity) which brings down the cost and power consumption.
NB-IoT is a narrow band specification that fits into the LTE standard. NB-IoT can also be deployed in GSM networks and even in the guard bands at the edge of each frequency band in LTE. NB-IoT is aimed at high-density, low-bitrate support of IoT devices. Release 14 added support for mobility to NB-IoT (asset tracking is one of its largest use cases), but the degree of mobility is not a great as for the other cellular standards. Maximum supported data rates in the latest version of the specification are 127 kbps on the downlink and 159 kbps on the uplink; as always, real-world data rates are substantially less than this.
NB-IoT only supports half-duplex operation which makes the front end design simpler. It is a single-antenna system which also reduces complexity, cost, and power requirements. It uses a 200 kHz bandwidth which is how it is compatible with GSM. Within the 200 kHz bandwidth, the channel bandwidth is 180 kHz which fits with LTE and is the width of 1 RB. The 180 kHz of usable bandwidth in the downlink needs to be compatible with LTE and so uses OFDM with up to a maximum of 12 of the15 kHz sub-carriers. The uplink is also compatible with LTE and uses SC-FDMA with 15 and 3.75 kHz sub-carrier options.
The latency is specified at less than 10 seconds which is at least two orders of magnitude slower than other standards. For systems that need a low latency, this is going to be an issue.
The latest addition to the cellular radio family is known, simply, as 5G. The 5G specification [7, 8] continues a trend from the earlier specifications of increasing the data rates over the link and also improving latency. Although improvements in latency (the delay over the network) were part of the aims of earlier standards, they became one of the main aims for 5G. The stated objectives for 5G are:
Data rate—5G is designed to deliver data rates ranging from 50 Mbps to 2 Gbps.
Latency—5G stated design target is 4 ms with 1 ms often being quoted as a target.
The data rate target is achievable in the lab but is more difficult to achieve in the field. To get close to data rates in the Gbps range, it is necessary for the transmitter and receiver to be relatively close.
With 5G a lot of new spectrum is being opened up. The radio interface specification, 5G NR (New Radio), defines two bands in the spectrum for 5G—FR1 (sometimes called “sub-6 GHz” even though it is specified up to 7.125 GHz) and FR2 or millimeter wave (usually known as mmWave). The FR1 spectrum is now also broken into low-band and mid-band in most discussions. Low-band spectrum starts at 410 MHz and includes the current cellular spectrum up to the 2.4 GHz ISM band. Mid-band is the spectrum above the 2.4 GHz ISM band up to 6 GHz (which is the cut-off for the 5 GHz ISM spectral band) although the 3GPP is specified out to 7.125 GHz. Although networks are being rolled out in the low band, the mid-band is where the highest number of new networks is being introduced as these frequencies offer the possibility of getting towards the desired bit speeds. Networks at the very lowest frequencies often do not offer much performance advantage over advanced 4G networks at the same frequency.
The mmWave band is new frontier spectrum for cellular radios. Whereas the 3GPP specifications are specified for unwanted transmissions up to 12.75 GHz, the new mmWave spectrum has bands from 24.25 GHz up to 52.6 GHz. Operating at these high bands opens up the possibility to have 400 MHz bandwidths for signals as 400 MHz at a frequency of 25 GHz is only 1.6% of the band frequency whereas it is 100% of the band frequency at 400 MHz. Unfortunately, these high frequencies are much more difficult to work with. The signals at these frequencies are easily blocked, and the available transistor gain is much lower requiring either extra current to drive circuits or special transistors to get more gain at cost. Any system that needs to use the mmWave frequencies will need to have more base stations to cover the desired area.
The modulation schemes used in 5G are essentially the same as those used in LTE. OFDMA is used on the downlink, and SC-FDMA is used on the uplink. Sub-carriers of 15 kHz are used but now 30, 60, 120, and 240 kHz sub-carriers have also been added [9]. The sub-carriers are modulated using QPSK as the base modulation and 16 QAM, 64 QAM, and 256 QAM can be introduced as the link quality improves. As in LTE, the waveforms have a high PAR even on the uplink, and this leads to lower efficiency from the power amplifier.
Even in some of the low bands, channel bandwidths of 100 MHz are available, and this will add extra complications to the design of the transmit circuitry and power amplifiers as the circuits can experience “memory” effects. In a circuit experiencing memory effects, the circuit performance changes due to the amplitude of the signal but does not change back in time to process a change in amplitude. Wideband modulations put a larger stress on the circuit because it must react faster. Memory effects require that circuits not be driven at their limits which means that they have to be backed off and are less efficient.
Another objective defined in the yet to be released ITU-2020 Standard for 5G to be able to service 1,000,000 devices in a square kilometer. This is a 100× improvement on 4G systems. This has been referred to as “Massive IoT”. The 5G specifications as they stand are too power-hungry for most IoT applications which do not need the bitrate and latency advantages of 5G. The 3GPP is working on IoT specifications to be included in the 5G specification in an equivalent way to LTE-M and NB-IoT for LTE and EC-GSM-IoT for GSM. At the time of writing, these specifications are not available.
Outside the cellular world, there are a number of radio systems that are designed with IoT applications in mind. These radios work in the unlicensed industrial, scientific, and medical (ISM) bands of the radio spectrum. The use of these bands does not require a license, but they are still regulated bands, and any radio working in them must meet the regulatory requirements. There are a number of ISM frequency bands available, but the most commonly used are the 2.4 GHz band which is heavily used by radio communications devices and the 5.8 GHz band that is used for wireless local area networks (LAN).
Frequency spectrum is available at 902 to 928 MHz in Region 2 (the Americas)—known as 915 ISM—which is popular for IoT applications because it is less than 1 GHz, and so signals that travel better and transmit powers up to 1 W (30 dBm) are allowed. In Europe (part of Region 1), the main low band of cellular communications overlaps with this band, and so it cannot be used. In Europe there is a band at 868 MHz as part of the short-range device (SRD) spectrum, and that is used, but the output power of the transmitter is restricted to 25 mW (14 dBm), so it is less useful than the 915 ISM band.
Many of the alternatives to cellular systems use base stations to connect to nodes although they usually refer to these “base stations” as gateways or access points (in the case of wireless LAN). Unlike the cellular system, there is usually no handover protocol defined, and leaving one gateway requires a hard break and reconnection with the new gateway.
A network with a base station sitting at its centre and multiple sensors communicating through it is known as a star network. In some of the technologies outside the cellular world, it is possible to have another sort of network where nodes connect to each other and communicate with one another. Such a grid of nodes is known as a mesh. Star and mesh networks are shown in Figure 18.
Star network and mesh network.
It is, of course, possible to combine star and mesh networks. Such a network is shown in Figure 19.
Star network with mesh networks.
The radio systems we will look at are Bluetooth Low Energy (BLE), Zigbee, 802.11ah, LoRaWAN, and Sigfox.
Bluetooth Low Energy (BLE) is an extension to the Bluetooth radio family controlled by the Bluetooth Radio Special Interest Group (SIG) specifically for IoT applications where long operation on battery is desired. Bluetooth Low Energy is not compatible with the previous versions of Bluetooth basic rate/enhanced data rate (BR/EDR). It is part of the Bluetooth 4.0 specification [10] and can be used alongside BR/EDR. The aim of BLE is to provide communications at the same range as BR/EDR at lower power and lower cost. It gives up voice capability and is purely data based in order to meet these aims.
BLE uses the same frequencies in the 2.4 GHz ISM as Bluetooth BR/EDR, but instead of 79 channels of 1 MHz each, it uses 40 channels of 2 MHz each. The modulation is Gaussian frequency shift keying (GFSK) which is a non-linear modulation which simplifies the design of the transmitter and uses less power than alternative linear modulations. In the Bluetooth 4.0 specification [10], the maximum output power was 10 mW (10 dBm). The maximum data rate is 1 Mbps.
One useful feature added with BLE is the concept of a mesh. BLE nodes can connect with their neighbors and pass a data transmission on to them. From one node it is possible to push a message across the whole mesh. This is another way of accessing an array of sensors rather than the central base station seen in cellular or gateways seen in other systems.
With the Bluetooth 5.0 specification [11], came some extensions to the BLE specification: higher power and higher data rate modes. The maximum power was increased tenfold to 100 mW (20 dBm) at a lower data rate of 500 or 125 kbps. This is expected to give a fourfold increase in range (power decreases with square of range from the transmitter, so a tenfold increase in power only sees a root-10 increase in distance). The maximum data rate was doubled to 2 Mbps but at a lower power.
BLE chipsets are designed to run off a standard coin cell battery and last up to 10 years. Although most BLE solutions will work for less than this you can still expect many years of operation.
There have been a number of cases of security vulnerabilities in Bluetooth being exposed. As ad hoc connections can be created, it is vulnerable to people pairing with devices which can, in the worst case, mean a loss of control. Also, one of the advantages of Bluetooth—the fact its communications can penetrate walls—is also a vulnerability as it can mean that a Bluetooth network can be accessed from outside a building.
Overall, Bluetooth, and in particular BLE, is an excellent radio protocol for IoT sensor nodes within a small geographic area providing the security issues are addressed. BLE offers no way to connect back to the Internet and hence cloud unlike cellular and some other systems; however it makes a good choice if the system needs to connect to multiple sensors through a local facility. In this case the system should also have computing at the edge capabilities to process data before sending the processed data into the cloud.
Zigbee is a networking protocol designed specifically for low-power and low-data rate devices. The Zigbee standard is developed by the Zigbee Alliance, but the physical (PHY—the lowest layer) and medium access control (MAC) layers are adopted from the Institute of Electrical and Electronic Engineers (IEEE) 802.15.4 specification [12]. This leaves only the network (NWK) and application (APL) layers in the Zigbee specification [13].
Zigbee is specified to work in the 868 MHz SDR, 915 MHz ISM, and 2.4 GHz ISM bands. In the 868 MHz band, one channel only is available, and BPSK modulation is used on that channel. Similarly, for the 915 MHz band, BPSK modulation is used, but there are 10 channels available. In the 2.4 GHz band, the modulation changes to OQPSK, and with the wider available bandwidth, 16 channels are available. ASK and OQPSK modulations are optionally available in the low bands for use in the case the 2.4 GHz channel is unavailable. Zigbee supports data rates in the 20–250 kbps range, so it is not suitable for many of the higher data rate applications but is well suited for many IoT sensor applications.
Output power in the 868 MHz band is limited to a maximum of 14 dBm which, with the BPSK PAR of about 2 dB, means the radio is limited to around a maximum of 12 dBm of output power. In the other bands, the regulatory limits are much high, and the highest power Zigbee radios can put out up to 20 dBm, but most transmit less. The line of sight range for Zigbee is quoted at 100 m maximum.
Two types of network can be set up with Zigbee devices: star and mesh. Combinations of the two types are possible. From this requirement, three different types of Zigbee device are needed: Zigbee coordinator, Zigbee router, and Zigbee end device. The Zigbee coordinator is the core of any Zigbee network. This is the node that will communicate with the outside world and control the whole network. Zigbee routers pass communications between each other but are not as capable as the Zigbee coordinator. Zigbee end devices will communicate only with either a Zigbee router device or the Zigbee coordinator and have minimal functionality. These will usually be the sensor nodes of the application. A Zigbee network is shown in Figure 20.
Zigbee network illustrating the role of three device types.
Zigbee is well designed for the purposes of connecting low data rate sensors in IoT applications at a local level. It is often criticized for not having enough security, so applications that use it may have to add their own data encryption on top which adds overhead and processing. It is not designed to connect back to the Internet and so to make the data available in the cloud.
The version of the wireless local area network (WLAN) specification designed to cover IoT usage cases is the IEEE 802.11ah specifications [14]. The other specifications in the 802.11 series (known as WiFi) are also useable in IoT applications but are primarily aimed at connectivity and are not optimized for IoT. The 802.11ah specification is also known as WiFi HaLow. While most of the wireless LAN specifications operate in the 2.4 and 5 GHz ISM bands (802.11ad, known as WiGig, operates at 60 GHz), 802.11ah will operate in the 868 and 915 MHz bands.
WiFi HaLow is designed for longer haul communications than Bluetooth or Zigbee being capable of coverage up to 1 km. The system uses OFDM in 2 MHz channels, and the modulations used on the sub-carriers are all phase modulations going from BPSK up to 256 QAM. Available bitrates go from 150 kbps up to 234 Mbps.
Unfortunately, although WiFi HaLow offers some advantages—the ability to ramp the data rate over a wide range is a useful property to have—the standard has not been taken up by many companies, and no large company is producing chipsets to support it.
LoRaWAN is an low-power wide area network (LPWAN) networking technology built on top of the Long Range (LoRa) PHY layer protocol [15]. LoRa technology is available in the 433 and 868 MHz bands in Europe, the 915 MHz band in the USA and some other nations.
LoRa uses a unique modulation scheme: chirp spread spectrum [16]. The carrier is modulated much like an FSK signal, but in this case the frequency is either increased linearly or decreased linearly with a continuum of frequencies. Such a continuum of linearly increasing frequencies is called a chirp. Bandwidth is fixed, so the chirp can only move between a minimum and maximum frequency; however the rate at which it does that movement can vary. A chirp is shown in Figure 21.
Chirp signal frequency vs. time representation and time domain signal.
There are three bandwidths available—125, 250, and 500 kHz—as well as six different slopes (known as spreading factors (SF)). For high data rates, the chirp will have a high slope and a correspondingly lower SF, and for low data rates, the chirp will have a low slope and high SF [17]. Start frequency determines the coding. On the receive side, the received symbol is multiplied with the inverse chip to extract the data. The higher the spreading factor, the longer the symbol that will appear in the receiver and the higher the likelihood of correct demodulation.
The LoRa modulation is a constant envelope modulation and as such lends itself to a compact transmitter and low power consumption. The nature of the modulation means that LoRa transmission can travel further for the same output power than many competing technologies. This makes LoRaWAN deployment attractive for rural and outdoor applications.
LoRaWAN is a networking technology built on top of the LoRa physical layer. The LoRaWAN network is a star network with individual nodes connecting back to a central gateway. This gateway is set up by the private company or individuals building the network, and this is one of the advantages of LoRaWAN—users build their own network and control their own data. Connection from this gateway to the Internet can be over Ethernet or fiber or can also be over the cellular network.
With LoRaWAN you are limited to 27 kbps data rate (there is an FSK option that can get up to 50 kbps). The other main limitation with LoRa technology is that it is only available on chips from Semtech Corporation. This limits the choice on performance and cost.
Sigfox is a French company that operates a network for IoT in the 868 MHz band in Europe and the 915 MHz band in the USA [18]. The Sigfox network is a star network with nodes communicating with base stations. Sigfox owns the base stations. The technology is designed for low data rate communications. The modulation is called Ultra Narrow Band (UNB) and makes use of a narrow bandwidth signal. The channels available are 200 kHz wide, but the bandwidth of the signal is only 100 Hz. With the narrow bandwidth signal, it is difficult to block the communication because any blocking signal needs to be right on top of the UNB signal. The carries are modulated using differential binary phase shift keying (DBPSK)—It is the value of the difference between a symbol and its previous symbol that is used for modulation not the symbol value itself and GFSK modulations. As the bandwidth of the communications is narrow, the data rate available is small—100–600 bits per second. Uplink messages are 12 bytes long, while downlink messages are 8 bytes long. A user is limited to 140 uplink messages a day and is only allowed to receive 4 downlink messages a day.
Sigfox is certainly something that should be considered if you have a low data rate application and do not want to communicate with the device that much—something that goes for a lot of sensor nodes. However, the message limits can be very restrictive.
As we have seen, there are many radio systems available and, those in this book are not an exhaustive list. However, every radio system has its advantages and disadvantages, and depending on the application, one radio system may be better than another.
Both BLE and Zigbee have the useful property of being able to support mesh networks. There are many instances where this may be useful: a network of sensors in a factory or a large office building or even a farm for instance. We could therefore envisage using Zigbee or BLE to network our sensors and bring the data back to a central place. At some point we will want to process that data. If the central location is in the offices of the factory, for instance, there may be no need to send the data any further. Figure 22 shows a Zigbee network controlled from smartphone app using Bluetooth.
A Zigbee network with Bluetooth link to smartphone control.
However, if the factory is part of a large network of factories, then the main office of the company may want to see the data. In this case we may want to make use of a cellular network to send the data back. In effect we have used the advantages of the two technologies—mesh technology for the local network and a secure, robust data link to send the results back. This would need some sort of local processing to put the data into a format that the main office can handle. Figure 23 illustrates this with a Zigbee network connected through local processing to the cellular network.
Zigbee local network with local processing and cellular connection.
We could send all the data from all the factories to the main office if we have a high-speed data link, but the head office may not want to process all that data. In this case, some form of computing at the edge is to process the data first and send a summary back (while storing all the data locally) to the main office. This also allows local management to catch problems quickly and start acting upon them before they get out of hand. If all decisions are taken at the main office based on data, they may miss problems because they have too many factories to check.
In the case of factories in remote areas with no access to high-speed data links, wired or not wired, it becomes necessary to compress the data sent back to the main office. In this case having local computing resources is a requirement. In fact, farms, oil facilities, mining facilities, highway rest stations, and many more places could all benefit by having networks of sensors linked up to a local processing facility with the data being sent back over another network.
We are familiar with radar in the context of ships and airplanes. These are large systems with large antennas. Recently advances in semiconductor technology have made it possible to integrate radars on chip. The initial application that started driving the development of radars was the reverse warning system for cars. However, radars are now used for proximity detection in cars and are even being used in autonomous vehicle applications. With the availability of cheap integrated circuits from a number of manufacturers comes interest in using radars in a variety of applications.
Radar is divided into monostatic and bistatic types. Monostatic radars either use the same antenna for both receive and transmit or co-locate the antennas if they are separate. Bistatic radars separate the receive antenna from the transmit by a considerable distance. We will concentrate on monostatic radars here, not because bistatic radars are not interesting for IoT applications—they may well be—but because all the available integrated circuits are monostatic.
We can further divide monostatic radars into pulsed and continuous wave (CW) types. Most current radar chips are of a CW sub-type called frequency-modulated continuous wave (FMCW) which is the least complex yet powerful.
A CW radar transmits a continuous wave—a single frequency—which then bounces back off a target and is received back at the receiver. In the receiver it is mixed with the original transmitted tone, and this mixing brings it down to sit at 0 Hz (DC). Unfortunately this means we get no information about the distance of the object, but if the object moves, we see a shift in frequency received due to the Doppler effect, and this shift in frequency is seen as a shift away from DC in the downconverted signal. We can use this frequency shift to give us the velocity of the object. This is the principle of speed detection radar guns. CW radar is very cheap to build because it only requires a stable oscillator, downconversion circuitry, and some basic processing.
If we want to be able to detect distance—critical in applications like proximity warning systems—then we need to move to FMCW radar [19]. In FMCW radar, the transmit pulse is a frequency-modulated signal. Although it is possible to modulate the transmit signal with different signals, the most common and simplest is to use a sawtooth waveform or triangular pulse waveform. The signal in this case is known as a chirp. A chirp is a pure continuous wave which either linearly increases or decreases in frequency. Chirps, incidentally, are used in LoRa for communication. Figure 24 shows the transmit and receive chirps represented as frequency vs. time and the relationship between them.
Radar transmit and receive signals and their relationship.
As can be seen, the transmit signal has changed frequency when the return pulse comes back. The difference in frequency may be small but it is measurable. Also as the transmit signal frequency slope is linear, the difference frequency, for a static object, will be a single frequency known as a beat frequency. From the beat frequency, we can calculate the distance to the object using the following equation:
where fbeat is the beat frequency,
If the object is moving away or towards the antenna, then we will get Doppler shift in the frequency, and we will be able to detect that as well. We will not be able to detect it if an object is moving around a circle that is equidistant from the antenna. In effect we have a two-dimensional system—distance to the object and velocity. The velocity is given from the Doppler frequency using the following equation:
where
With a single antenna, we have distance to a target and velocity of the target relative to the antenna. If the antenna is idealized as an isotropic antenna (equal transmission in all directions), then we will have a sphere around the antenna at the distance to the target where the target could be. By adding a second antenna, we would have two spheres of potentially different size, and the target would lie somewhere on a circle at the intersection of the two antenna’s spheres. Fortunately, real antennas are not isotropic and tend to be directional. In this case our spheres become distorted, and our circle becomes an arc. This is much more useful.
The antennas used with radar chips can be built into the package or are on the board. In either case they are patches of one sort or another which will transmit in much better away from the board or package than into it and behind it. By putting two antennas next to each other with at least half a wavelength distance at the radar frequency between them, we can determine where the target is on a plane stretching from left to right of the radar but not if it is above or below it. By adding a third antenna above the other two, we now know where, exactly, the target is in three dimensions relative to the antennas.
We already know that we can extract velocity towards or away from a single antenna but not the velocity of an object moving in a sphere around the antenna. However with more than one antenna, the object will always be moving relative to at least one of the antennas. So in the three-antenna configuration, the target will have velocity components that we can extract towards and at right angles to the path towards the antenna for each antenna. We can, therefore extract velocity information as well as direction of travel. This, in effect gives us four dimensions—the three special dimensions and velocity.
A common configuration of transmits in FMCW radar integrated circuits is two transmits and four receives. This configuration can be used to obtain a full 4D picture of the environment in front of the radar.
We can also extract other information about the target. In general, the return signal will also tell us how big the target is. This does, however, depend on the material the target is made of. Metal reflects radar radiation much better than, say, a human does or even a brick wall, and so a metal plate will appear relatively large. However, a human will reflect more than a dog, and so we are able to infer whether we have a human or an animal in front of the radar which may be useful in some remote monitoring applications.
The processing required for FMCW radars is relatively simple. The digitized signal from the received signal is collected into a frame of a given number of samples, and this frame is fed into a discrete Fourier transform (DFT) usually implemented using an fast Fourier transform (FFT) algorithm. This gives us a spectrum of the signal where individual peaks will represent object and the frequency associated with that peak can be used to calculate the distance to the object. A second level of processing is then used to extract the velocity information. The spectra generated in the first stage are collected into another frame which now has two dimensions—time along one axis and frequency along the other. A DFT, again using an FFT algorithm, is run on this frame, and this gives us the velocity information at each frequency.
This processing needs to be performed for each antenna, and then the results need to be combined to give a full 4D picture of the world in front of the antenna. This signal processing is specialized but involves well-known algorithms and so is not particularly arduous to implement. FFT algorithm implementations are available in dedicated hardware blocks, and it is possible to build a hardware engine to perform the processing which would be significantly power-saving over a software implementation on a general-purpose processor. With dedicated hardware blocks to perform most of the processing required for the radar and a general-purpose processor to perform user programmed functions, we could build a flexible and high-performance imaging sensor unit which runs on relatively low power.
Radar is a different sort of imaging sensor. It does not offer the sort of high-resolution images that are available from cameras, but it does have advantages over cameras in many applications. In general an FMCW radar installation will be of lower power and require less bandwidth from the communications systems than a video installation would. Even if the video images are processed locally, FMCW processing is a lot simpler than image processing for many applications and so requires smaller memories and computers and less power. Radar will also work in fog, rain, sleet, and smoke making useful in a wide range of applications. For applications that require identifying individuals or certain states (wearing a helmet or not, for instance), radar will not do the job, and image processing will be necessary. However, for some applications there are power constraints, a variety of atmospheric conditions may be encountered, or there is a privacy concern—monitoring of changing rooms or public toilets for instance—so for other applications, radar is a better fit. The next few sections will go over some of these applications.
FMCW radar is a good choice for monitoring applications. Video is used extensively in the security industry, but humans are notoriously bad at monitoring video feeds, and a system based on image processing and some sort of machine learning would be power-hungry. Generally, we are only interested in things that move—it is impossible to steal or damage something without getting close to it and physically moving it. Radar can tell you not only that something is moving but also how fast, in what direction, and even roughly how big the moving object is. It can also tell you how far away something is, so monitoring fluid level in a tank is also another good application of FMCW radar. Other non-security applications like automatic door opening (where the system can tell people are approaching the door rather than just passing) and people counting are also an extension of this monitoring.
For people that are close enough, FMCW is able not only to detect breathing but also heartbeat [20]. This is potentially extremely useful in many applications. An obvious example is disaster relief where radar can be used to detect people trapped in the rubble of a collapsed building. In home monitoring of the elderly is another potential application and one where radar is a better fit than cameras as it does not violate the privacy of the old person being monitored. There are numerous potential uses in the medical field including monitoring of sleep quality and looking for signs of sleep apnoea.
Google has a project, Soli, that is developing solutions in using radar for gesture recognition [21]. Doppler radar can detect movement, and this movement can be deliberately coordinated to convey information—gestures. Gestures can be inferred by using machine learning (ML) to recognize which particular radar signature belongs to which particular gesture. Using this system gestures can be used to control equipment around us much like a television remote control.
As we have information about an object’s position in all three cardinal dimensions and its velocity (with direction on the velocity), radar can be used to extract gait information. From the gait information, we will be able to identify a person from the way they walk. However, gait is also related to mental faculty. In fact, there is an ongoing medical research on using gait to give an early indication of neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. In the future it may be possible to combine gait analysis with other analyses in a home monitoring application for the elderly based on FMCW radar devices.
Cellular radio systems are set up with mobility in mind. Also, as the original systems were often voice, the transmit and receive systems were set up with equal bandwidth and data rate considerations. As data communications came to dominate, the systems that adjusted for the asymmetry in the data needs made the adjustment assuming the data needs would be higher on the downlink. For instance, streaming video needs a high bandwidth and high data rate on the downlink but not much on the uplink. This, as if happens, fits well with the requirements of mobile devices: mobile devices run off battery systems and so have limited power available. Keeping the upload data rate and modulation simple allows for a more efficient PA and hence saves power.
Many IoT systems will consist of fixed nodes sending data back to a fixed node with very little need (or possibly even ability) to receive data. In effect they need support for a higher data rate on the uplink than on the downlink. This is the opposite of the mobile client case, and so radio systems designed with a mobile client in mind may not be optimal for many IoT applications. It should also be obvious that the performance of the transmitter for an IoT sensor node is of much more importance than the performance of the receiver. In fact, in the simplest sensor nodes that continuously blast data out, there is not even a need to have a receiver.
In an IoT system with the position of sensor nodes fixed, there is no need to support overheads in the radio system for mobile clients. This means overhead to support handover and multiple base stations are not needed. Fading as a result of the client device’s movement will not be an issue; however changes in the environment around the radio may still contribute to fading although it should not be as deep as in a mobile application. This means it would be prudent to include interleaving.
The requirements for a wireless system for IoT depend on the usage case. For a system that sends back temperature data every few hours for instance, the wireless system used to send the data back would not need to handle a high data rate, but it would probably be desirable that it is robust and of low power. Also, the distance that needed to be covered would need to be considered, and so transmit power and transmit efficiency would be a factor in the system selection. With a low data rate requirement, the link robustness could be somewhat traded off as ARQ error correction would be possible. If the system needed to operate off a battery, the power dissipation of the wireless link would be a big factor if not the biggest factor in overall power dissipation. This would make the choice of wireless link critical.
A system sending back a continuous video feed would need to have a much higher data rate than a simple system returning a single sensor reading. It would need to be much more robust as it would not be able to make much use of ARQ without a significant bandwidth overhead. Battery operation is not practical unless the battery is large or there is some mechanism for battery recharging (solar, wind power, diesel generator).
It is possible to envisage a system which needs different requirements at different times. For instance, in a system to automate agriculture, we may use a combination of sensors strategically placed to measure temperature, moisture, sunlight, and other conditions. These sensors could be linked via a low-power radio system like Bluetooth or Zigbee back to a local control centre in the middle of the fields being monitored. The local control area processes the data from the sensors (an example of computing at the edge) and is linked back to a central control centre over a cellular link. The central control centre controls agricultural operations over a wide geographic area.
Normally, the local control centre would not need to send much data back—temperature, hours of sunshine during the day, light intensity, soil moisture, and so on. However, there may be circumstances where we need to inspect the location quickly—a sudden rise in temperature in one area indicating a fire and sensors in one area suddenly going down. As it is a remote location, we do not want to send someone out to check because it may be too late by the time the inspection team gets there. This is a realistic prospect in countries with a rapidly aging population where there is no manpower available to work in agriculture. In this case we would want to send a robot or even a drone over to inspect from the local control centre. If we must drive the robot or fly the drone from the central control centre, we will need a high bandwidth link to the local control centre and from there to the robot or drone. The solution is to put resources close to the drone or robot—people or computing. Having computing resources available at the edge to control the drones makes a lot of sense.
Even if the drone or robot is fully autonomous and the fields and local control centre are equipped with a 5G network so any video sent back is received at full definition, we still need a high-speed link to get that video data back to central control centre, so we can see what is going on. In this case we need to be able to ramp the communications speed up by several orders of magnitude which is not possible with today’s radio technology. It may even be necessary to install a point-to-point wireless link if the only way decisions can be made is to get the data back. To get away from the need to have a high-speed link, it is necessary to move the computing resources close where they can monitor the video data. A system that can recognize a fire and send a message “there is a fire” is more useful than “we have a problem”.
As bandwidth increases, the bitrate that can be supported with the simplest modulations increases with it. If the bandwidth is fixed (as it is by regulatory requirements for wireless systems), then the only way to increase bitrate is to use deeper phase and amplitude modulations (16–64 QAM). A wide bandwidth system using a higher-order modulation will quickly run into physical limits: the higher modulation is pushing the acceptable noise level down as a larger signal-to-noise ratio (SNR) is needed, yet the wider the bandwidth means more noise, as noise is integrated over bandwidth. If you are transmitting at full power, then the only way to get more SNR is to move the transmitter closer to the receiver (or vice-versa).
If your application needs both high bitrate and needs to work over long distances, you need to reconsider your system. Is the sensor you are using appropriate? A lot of solutions use vision (a video camera) with AI software to perform their task. Video images consume a lot of bandwidth. Is there not some other sort of sensor that can do the job? Could it be done using radar, for instance? If the answer truly is no, then you will need to consider moving the computing closer to the camera. If you can do all or the bulk of the processing at the edge, what is the size of message that needs to be sent?
If the system has a high-bandwidth and a low-latency need, then the only choice will be 5G. The low-latency requirement will force you to move your computing to the edge because of the delay between the base station and the server. Although 5G promises 4 ms latency, the latency over the air is already twice that in current generation products, and the delay between the base station and the server can be 20 ms or more.
There are many radio systems available for IoT applications. Some may be suitable, and many will not.
Most IoT applications will not have access to either a wired power supply or a wired communications system. Systems built to work in these applications are, by default, going to need a wireless system to connect to the outside world. They are, by their nature, also going to be running off batteries, and so power consumption is a critical design specification for them. High data rate systems are going to consume more power than lower data rate systems. It is probably the case that moving the computing to the edge will remove the need for a high-speed link and may make it possible for a sensor node off a battery.
For wireless communications systems, a general rule is higher data rate requires more power. Also, the higher the bandwidth, the more difficult it is to set the system up: the position and angle of the antennas, what other devices are working around the system, and what are the obstacles in the way between the transmitter and receiver, amongst many reasons, all play into performance. Wherever there are high-speed data needs, the transmitter and receiver need to be close to each other. Adding computing closer to the edge can decrease the data requirements and make the implementation more practical.
One of the most useful and overlooked wireless systems is the SMS system that comes with all cellular systems. You can use SMS on 5G, 4G, 3G, and 2G systems throughout the world. It works on 2G systems in some of the more inaccessible locations. In order to make use of the SMS system, it is necessary in many instances to process the data first to compress it before sending. With a computing at the edge system, it becomes possible to make use of a truly useful system for getting data back.
Finally, if low latency is needed in a 5G system, the computing will need to be as close as possible to the base station. 5G promises 4 ms latency—we aren’t there yet with more like 10 ms latency over the air only. If the data has to go back to the central servers to be processed, the latency would be more like 30 ms or more than 4 ms—hardly what 5G promised.
Democracy has formed the foundation of governance in the world, with every voter willing to express his/her views on the ballot [1, 2]. Elections have been held manually and electronically in both the developed and developing nations, some results have ended in contestations and wars erupting after the elections. Covid-19 has had a devastating effect on the political, social, and economic spheres in the world [3]. The way of running elections was also affected by this pandemic as nations sought to find ways of halting the spread of the disease. In developed nations countries like Estonia and other American states have been implementing Internet voting.
Africa is constituted by 54 countries with diversified democracies [4]. Eritrea is the only country that does not hold regular elections as has continuously postponed elections citing security threat from its neighbors Ethiopia and Djibouti. The African nations have diversified electoral systems, with some countries like Zimbabwe implementing first past the post and proportional representation, and South Africa, the proportional representation in their polls [5]. Most of the African countries hold regular manual elections as demanded by the United Nations Universal Declarations on elections.
The prospects for the growth of democracy in the 21st century in Africa depend on how the continent positions itself for value-adding services such as Internet voting. Covid −19 has forced the world to quickly develop and implement Information Communication Technologies (ICT) opportunities previously unimaginable. For Africa to take advantage of this, an effective enabling environment and use of ICTs is a particularly important contributor to modern democracy.
Internet voting is where a ballot is cast by the voter through the Internet [6]. The use of Internet voting gained popularity in Estonia since 2001. Estonia is the first country to carry out a successful pilot project in municipal elections in 2005. Estonia went on further to first use Internet voting in the 2007 parliamentary elections [7].
The four kinds of Internet voting are kiosk Internet voting, polling-place Internet voting, precinct Internet voting, and remote Internet voting (Canada-Europe Transatlantic [8]). Kiosk Internet voting involves the use of a computer at a specific location (an authorized internet polling station) that is controlled by election officials. This differs from a standalone electronic voting machine because the ballot is immediately transmitted over the Internet to the central vote-counting site. Polling-place Internet voting is conducted through the use of a computer at any polling station and is supervised by the usual election officials. Precinct Internet voting is very similar to polling-place voting except that it must occur at the voter’s designated precinct polling station (voters are only allowed to cast their ballots at polling stations where they are registered). Remote Internet voting is where a voter cast the ballot from the comfort of their homes or where the is Internet provision [9]. The advantages, disadvantages, and countries that are implementing Internet voting are shown in Table 1.
Internet Voting type | Advantages | Disadvantages | Countries implementing the system |
---|---|---|---|
|
|
| Australia (for military and persons with disabilities only), Austria, Canada, Estonia, Netherlands, Switzerland, USA (for the military-), UK (project canceled) |
|
|
| France |
|
|
| Australia, Belgium, Brazil, Canada, Finland, France, Germany, India, Ireland Netherlands, Norway, Portugal, Spain, Switzerland, United Kingdom, United States of America |
|
|
| |
|
|
| Netherlands, United Kingdom |
As shown in Table 1, Internet voting is necessitated by the demographics of a country especially people living abroad who would want to exercise their democratic right but will not be residing within the citizenry country during an election. Chisinau [11] argues that Internet voting will allow voters to cast their ballots at the comfort of their homes or convenient places. Voting through the Internet is easier as voters can cast ballots using their own devices and there is no time wasted in long queues. Voters do not travel long distances, thus reducing transportation costs and can do other business chores. It allows for inclusivity as people living with disabilities or serious medical conditions can exercise their democratic rights. Internet voting will also allow those people who will be traveling or will be on duty during election day to cast their ballots anywhere in the world [12].
The disadvantage of Internet voting is that it consists of a large complex network which makes it difficult to monitor the entire network, thus posing a serious security threat. The monitoring of the network is very expensive of which there is no 100 percent guarantee that the network will be secure. Hackers could use malware to rig the outcome of the elections, by tampering with the way votes are submitted and counted or even casting votes for people who did not vote. Internet voting may be a source of conflict between political parties if one party considers that Internet voting might be beneficial to the other party/parties [12].
The critical socio-technical analysis [10] which is premised on analyzing an information system during the systems development life cycle was used to identify key factors in the applicability of Internet voting in Africa. By finding key factors affecting the applicability of Internet voting in Africa, it is expected that decision-makers would come up with strategies that support the successful implementation of such systems.
African Electoral Management Bodies (EMBs) have been using manual systems in general elections for the past decades which has resulted in disputed elections, high operating costs affecting the Gross Domestic Product (GDP) because of systems and processes inefficiency. Only two countries, the Democratic Republic of Congo and Namibia have used polling stationed-based electronic voting machines which do not have Internet connectivity [13]. Covid-19 has not helped the situation either as countries have been forced into lockdowns, compelling nations to postpone elections. The introduction of Internet voting especially casting a ballot outside a polling station is the most difficult technological upgrade for an Electoral Management Body (EMB) as it involves the core of the entire electoral process [14]. This chapter investigated ‘why’ and ‘what’ factors were affecting the applicability of Internet voting in African general elections.
In this study, desktop research was used to collect data from 30 journals and other documentation about factors affecting the applicability of Internet voting in Africa. The critical socio-technical analysis was then used to guide this study in the search and analysis of factors such as political, social, technical, legal, security, privacy, trust, and transparency affecting the applicability of Internet voting in Africa. These factors were selected after critically analyzing contemporary issues in developing and developed countries successfully implementing, on trials or have abandoned the implementation of Internet voting.
While the benefits from Internet voting will guarantee the rights of citizens to exercise their democratic rights, the study discovered that no country in Africa is implementing Internet voting in general elections. The factors affecting the applicability of Internet voting in Africa are political, legal, social, technical, security, privacy, transparency, and trust.
Africa has the most number of people that flee their countries seeking greater opportunities from developing and developed nations [15]. Citizens from African countries migrate to other countries due to the effects of climatic changes, such as droughts, storms, and flooding. Other factors such as economic and political stability (wars) also force nationals to migrate to other countries seeking better opportunities [16]. The migration of people allows African countries to offer their citizens their democratic rights by allowing them to vote through the Internet. Some African governments also tend Internet shutdowns citing national security or curbing the spread of fake news during elections, for example, the Ugandan, Libya, Malawi, and Sudan Presidential elections [17] which makes it difficult to implement Internet voting.
The legal framework allows voters to exercise their rights during an election or absentee voting through the Internet [18]. For African citizens living abroad or who will be committed during election day to exercise their democratic right, there must be legislation that supports Internet voting. The legal framework empowers the EMB and other stakeholders to remove the element of mistrust, as the voting process is done within the confines of the law. At the moment no country in Africa is exploring the use of Internet voting rendering the introduction of such legislation a futile exercise.
African countries are still facing challenges in the implementation of mobile communication and Internet technologies [19]. Countries like Somalia, South Sudan, and Mozambique have often been affected by ravaging wars, which destroys infrastructure and forcing these countries into retarded economic growth. As shown in Table 1, the limitation in the Internet penetration factor is that the network service providers do not provide 100% service coverage. This makes it practically impossible to offer Internet voting within the country for national general elections as some other communities will be disadvantaged by failing to access the service to cast their ballots. The penetration of internet communication in Africa is very low at 43% as shown in Table 2. Countries like Kenya, Libya, Mauritius, Nigeria, Morocco, Seychelles, and Tunisia have a higher national Internet penetration factor. These countries can partially implement Internet voting in some of their regions. Other African nations especially that are below 50% like Eretria, Togo, Western Sahara, South Sudan, Sierra Leone, and Somalia will have difficulties in implementing Internet voting nationally.
Country | Estimated Population | Estimated Registered Voters | Estimated Voter population | Internet Users 31 December 2020 | Penetration (% Population) |
---|---|---|---|---|---|
44,616,624 | 24,474,161 | 27,992,084 | 25,428,159 | 57.0% | |
33,933,610 | 4,992,399 | 5,967,849 | 8,980,670 | 26.5% | |
12,451,040 | 4,802,303 | 5,378,554 | 3,801,758 | 30.5% | |
2,397,241 | 924,709 | 1,444,142 | 1,139,000 | 47.5% | |
21, 497,096 | 2,395,226 | 2,497,500 | 4,594,625 | 21.4% | |
12,255,433 | 5,113,418 | 5,863,257 | 1,606,122 | 13.1% | |
561,898 | 392,731 | N/A | 352,120 | 62.7% | |
27,224,265 | 6,900,928 | 13,001,295 | 7,878,422 | 28.9% | |
4,919,981 | 1,954,433 | 2,005,942 | 557,085 | 11.3% | |
16,914,985 | 6,252,548 | 5,809,346 | 2,237,932 | 13.2% | |
888,451 | 313,647 | 474,387 | 193,700 | 21.8% | |
5,657,013 | 2,221,596 | 2,617,983 | 833,200 | 14.7% | |
92,377,993 | 40,371,439 | 44,138,661 | 16,355,917 | 17.7% | |
27,053,629 | 7,359,399 | 15,503,401 | 12,253,653 | 45.3% | |
1,002,187 | 215,687 | 609,344 | 548,832 | 54.8% | |
104,258,327 | 63,157,351 | 63,705,978 | 54,741,493 | 52.5% | |
1,449,896 | 325,555 | 417,365 | 362,891 | 25.0% | |
3,601,467 | N/A | N/A | 248,199 | 6.9% | |
1,172,362 | 546,784 | N/A | 665,245 | 56.7% | |
117,876,227 | 36,851,461 | 49,011,364 | 21,147,255 | 17.9% | |
2,278,825 | 680,194 | 1,177,350 | 1,367,641 | 60.0% | |
2,486,945 | 886,578 | 1,151,645 | 442,050 | 19.0% | |
31,732,129 | 17,027,641 | N/A | 14,767,818 | 46.5% | |
13,497,244 | 5,410,089 | 6,556,813 | 2,551,672 | 18.9% | |
2,015,494 | 645,085 | 935,920 | 250,000 | 12.4% | |
54,985,698 | 15,590,236 | 25,374,082 | 46,870,422 | 85.2% | |
2,159,079 | 1,254,506 | N/A | 682,990 | 31.6% | |
5,180,203 | 2,183,629 | 2,319,382 | 760,994 | 14.7% | |
6,958,532 | 1,509,218 | 4,029,365 | 5,857,000 | 84.2% | |
28,427,328 | 10,302,194 | 14,291,036 | 2,864,000 | 10.1% | |
19,647,684 | 6,859,570 | 10,030,988 | 2,717,243 | 13.8% | |
20,855,735 | 7,663,464 | 8,920,714 | 12,480,176 | 59.8% | |
4,775,119 | 1,417,823 | 2,125,242 | 969,519 | 20.3% | |
1,273,433 | 941,719 | 1,044,325 | 919,000 | 72.2% | |
279,515 | N/A | N/A | 107,940 | 38.6% | |
37,344,795 | 15,702,592 | 23,126,996 | 25,589,581 | 68.5% | |
32,163,047 | 13,153,088 | 13,554,684 | 6,523,613 | 20.3% | |
2,587,344 | 1,358,468 | 1,479,603 | 1,347,418 | 52.11% | |
25,130,817 | 7,446,556 | 9,623,301 | 3,363,848 | 13.4% | |
211,400,708 | 82,344,107 | 106,490,312 | 154,301,195 | 73.0% | |
901,686 | 110,968 | N/A | 608,000 | 67.4% | |
13,276,513 | 7,172,612 | N/A | 5,981,638 | 45.1% | |
6,086 | 2,309 | N/A | 2,300 | 37.8% | |
223,368 | 97,274 | 105,318 | 63,684 | 28.6% | |
17,196,301 | 6,683,043 | 8,071,074 | 9,749,527 | 56.7% | |
98,908 | 74,634 | N/A | 71,300 | 72.1% | |
8,141,343 | 3,178,663 | 3,284,182 | 1,043,725 | 12.8% | |
16,359,504 | 4,220,466 | N/A | 2,089,900 | 12.8% | |
60,041,994 | 25,809,443 | 37,372,792 | 34,545,165 | 57.5% | |
11,381,378 | 4,800,000 | N/A | 900,716 | 7.9% | |
44,909,353 | 13,126,989 | 19,667,400 | 13,124,100 | 29.2% | |
61,498,437 | 29,754,699 | 29,480,237 | 23,142,960 | 37.6% | |
8,478,437 | 3,738,786 | 4,645,140 | 1,011,837 | 11.9% | |
11,935,766 | 7,065,885 | 8,219,612 | 8,170,000 | 68.4% | |
47,123,531 | 8,219,612 | 8,219,612 | 18,502,166 | 39.3% | |
611,875 | N/A | N/A | 28,000 | 4.6% | |
18,920,651 | 6,698,372 | 7,331,669 | 9,870,427 | 52.2% | |
15,092,171 | 5,695,706 | 7,650,931 | 8,400,000 | 55.7% | |
1,373,486,514 | 590,296,163 | 43.0% | |||
6,502,279,070 | N/A | N/A | 4,463,594,959 | 68.6% | |
7,875,765,584 | 5,053,891,122 | 64.2% |
Internet users statistics for Africa.
There is a wide gap between the digital divide within the African nations especially between the urban and the rural community, the elderly, and the young generations [20]. The young generations have embraced technology as they use smartphones and laptops as communication and business tools. A large population in African countries live in rural communities. Some of these people cannot afford to buy gadgets, power, and data used for Internet services. There is also a lack of digital skills and literacy among the communities both in urban and rural setups especially among the elderly. The content or language used on the Internet makes it difficult for some African communities to comprehend the importance of using such services. Hence the use of Internet voting in African countries will be difficult because of the digital divide.
Internet voting should be secure for the results to be credible [21]. Key factors such as freedom, and equality during an election are important aspects of security requirements for Internet voting. The transmission of all voting data to servers or tabulation centers must be secure. All voting which is done whether on the Internet or otherwise should be granted the same status as any other vote cast in the same election. This means that each vote should be given the same weight as it also determines the outcome of an election [22]. Various encryption methods have been suggested for use with Internet voting including the blockchain [23]. African countries should have networks that can encrypt ballots cast over the Internet without the network being compromised, overloaded, or due to other disruptions like shutdowns.
With the use of Internet voting, an EMB has to ensure that each vote cast remains a secret. A free election means that the voter must not be coerced by public or private pressure. After voting through the Internet, the voters should have an acknowledgment for the candidate that they have voted for. All ballots cast through the Internet should be accorded the same secrecy as in manual systems [24]. If a ballot is cast, the voter’s identification details must be able to be authenticated and not linked to the ballot. The vote cast should also be accounted for in the outcome without identifying the voter. In Africa voter intimidation remains a serious challenge [25], thus through Internet voting, voters may be coerced to vote for undeserving candidates.
Trust in Internet voting can only be accepted if the results from this service are credible. The EMB should assure voters that their votes are secure and secret. To build trust voters should also be able to verify that all collected ballots were from eligible voters and that they have been accurately counted [26]. If Internet voting is to be implemented in African countries pilot testing has to be undertaken to allow voters to test the system before being fully implemented in a general election. To build trust among stakeholders (voters, activists, and media) an EMB should be transparent in all the activities involved with Internet voting. To avoid mistrust from the public, the stakeholders should be educated on how Internet voting works and also made to appreciate the qualities of the system. Relevant information should be availed in a language that can easily be understood by the public. The information should include full technical documentation of how the system is designed functionally and technically, all levels of software documentation, source code, and the technical and organizational environments where the system is hosted.
With the advent of the Covid-19 pandemic causing deaths, and unavoidable shutdowns, elections cannot be suspended indefinitely, decision-makers have to find alternative ways of conducting elections without compromising the health and safety of the electorate. Internet voting is one such method that may guarantee the health and safety of the electorate where voters can vote in the comfort of their homes. Decision-makers have to take note of the following during feasibility studies and implementation of Internet voting:
Politically, it is fundamental to foster a broad consensus among political parties for the implementation of Internet voting. This involves transparency where the relevant actors have a voice. Internet voting should be seen as politically neutral that is the new procedure should not benefit disproportionally given factions of the political spectrum [27]. For electoral results to be accepted by voters, Internet voting must produce an outcome that reflects the will of the people in an environment that establishes transparency and trust [14].
Technological and security concerns are often pointed to as the main concern of Internet voting [28]. To validate and verify the technological voting system the set of technological requirements have to be consulted systematically. In Africa, some voters live in remote areas but may also want to cast their ballots using the Internet. African countries have limited Internet infrastructure which should prompt governments to improve this area if its citizens are to benefit from Internet voting. The improvement on the infrastructure would also benefit an EMB during the voter registration process, as voters will be able to register through the Internet.
There have been numerous attacks of electronic voting systems over the Internet with the 2016 American Presidential election being the most contentious election of the decade [29]. The stakes of any general election are always high, which may create interests chief among them malicious actors-particularly in countries with specific geopolitical adversaries who may specifically create and deploy attacks or malware designed to manipulate the vote. In Africa, the use of Internet voting which has got limited transparency and audit trail may lead to manipulation and voter fraud. It will be very difficult to monitor votes cast over the Internet, to build trust among the citizens an EMB has to be trusted in pursuing its mandate.
Most electronic voting systems are now being developed with blockchain encryption [30, 31]. Blockchain technology is an end-to-end encryption method that secures ballots transmitted from voters’ private devices to a centralized tabulation facility. However, it has been observed that most serious vulnerabilities threatening integrity and secrecy of voting happen before ballots ever reach the blockchain. Voters may be coerced by family members or other pressure groups to vote in a certain way that does not reflect their will. It is also difficult to validate if the voter is the real one casting the ballot which is crucial to the credibility of an election. Estonia, for instance, has resolved this issue without blockchain by using e-ID cards. Blockchain technology also does not protect against -denial-of-service attacks that make servers unable to operate, does not protect information as it travels on the Internet, and does not make servers and infrastructure more resistant to advanced persistent threats. Despite improvements in encryption techniques, security will always remain a challenge for Internet voting.
The major social challenge is the digital divide as some parts of the population remain excluded from Internet voting and that gap exists in African countries regarding computer literacy and household Internet usage and availability. The ‘Digital transformation Strategy’ adopted by African countries in February 2020 should be pursued to narrow the gap between the digital divide in urban and rural communities and also narrow the ‘gender digital divide’ [32].
Currently, most African countries do not have any legislation that supports Internet voting. The legal framework should be put in place to allow for Internet voting, which should clearly state who is eligible and the reasons that support eligibility.
Despite low usage in Internet voting around the world, Estonia is the only country that has fully utilized this service in general elections. Table 3 highlights countries that have fully, partially, piloting and discontinued the use of Internet voting.
Internet voting used in General Elections | Partial use of Internet voting and Special cases | Planned to be piloted or Piloted but Discontinued or Never Used |
---|---|---|
Out-of-country residents also voted online in the 2016 Republican party primaries. | ||
In 2004, the | ||
One of the first experiments to introduce Internet voting was conducted by the Electoral Commission of the Volgograd Region during voting in Uryupinsk in 2009, and the Odintsovo district in 2010. | ||
Countries that use internet voting (use of internet voting outside of polling stations in politically binding elections).
The success of Internet voting depends largely on how it is perceived by the people meant to use it: citizens. For example, Internet voting is difficult to be transparent as compared to manual systems. The transparency and reliability of Internet voting have been questioned, as this is electronically done. Therefore, it is fundamental to know what their attitudes towards the implementation of Internet voting would affect them.
The applicability of Internet voting in Africa largely depends on how the nation’s willingness to adapt to new technology in the face of challenges such as political, legal, security, privacy, trust and transparency, the digital divide, and limited infrastructure. The successful experience of countries such as Estonia highlights the importance of a gradual, step-by-step design and implementation of Internet voting which may be used for benchmarking. It is also recommended that the perception of the citizens should be taken into consideration. African nations should also make an effort to improve the internal coverage of Internet services within their territories.
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Aptamers are comparable to monoclonal antibodies, which are well-established therapeutic molecules, in terms of specificity and affinity to their target. The advantage of aptamers over antibodies includes their high stability, ease of synthesis, less batch-to-batch variation, easy chemical modifications that allow different conjugation chemistries, small size for better tissue penetration and low immunogenicity. These advantages make aptamers an important tool for use in therapeutics for targeted delivery. However, aptamers do have some limitations that have hindered their widespread clinical use as a therapeutic agent. Some of their common limitations include serum stability, renal filtration and endocytic escape. Other limitations that are more specific to aptamers include lack of diversity in the aptamer library, nuclease susceptibility and claims of aptamer specificity as well. This book chapter sheds light on these challenges, and using examples, it explains the scientific advancements that have been achieved in overcoming these limitations. We will end this chapter by discussing the use of high-throughput technology, which is the only way of truly industrializing the aptamer technology akin to the development of small molecule drugs.",book:{id:"7663",slug:"role-of-novel-drug-delivery-vehicles-in-nanobiomedicine",title:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine",fullTitle:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine"},signatures:"Chetan Chandola and Muniasamy Neerathilingam",authors:null},{id:"70614",doi:"10.5772/intechopen.90365",title:"Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery",slug:"cyclodextrin-nanosponges-a-promising-approach-for-modulating-drug-delivery",totalDownloads:934,totalCrossrefCites:7,totalDimensionsCites:12,abstract:"Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper cross-linked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.",book:{id:"7604",slug:"colloid-science-in-pharmaceutical-nanotechnology",title:"Colloid Science in Pharmaceutical Nanotechnology",fullTitle:"Colloid Science in Pharmaceutical Nanotechnology"},signatures:"Sunil Kumar, Pooja Dalal and Rekha Rao",authors:null},{id:"70345",doi:"10.5772/intechopen.84424",title:"Polymer Properties: Functionalization and Surface Modified Nanoparticles",slug:"polymer-properties-functionalization-and-surface-modified-nanoparticles",totalDownloads:1049,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"Herein, the various polymer properties and the underlying mechanism for the functionalization and surface modification of polymer nanoparticles have been discussed. There are numerous polymer particles designed and developed for various applications. The synthesis and characterization of different types of polymers followed by the engineering of nanoparticles and capsules depend on various factors. There are too many polymerization methods approached for the development of nanoparticles with desired surface properties. The ring-opening polymerization (ROP), emulsion polymerization (EP), atom transfer radical polymerization (ATRP), and free radical micro initiation are the significant approaches for the polymerization reactions. The polymer nanoparticle functionalization and modification of their surfaces based on requirements is an essential task. The solvent concentration, pH, temperature, and sonication have played a vital role to tune the morphology of polymer nanoparticles and capsules. Different characterizations such as FTIR, NMR (1H and 13C), HRMS, and MALDI-TOF are used for preliminary structural and confirmations. Further, SEM, FE-SEM, TEM, AFM, BET, XRD, Raman, EDAX, TGA-DSC, DLS, and zeta potential were used for morphological and thermal properties.",book:{id:"7663",slug:"role-of-novel-drug-delivery-vehicles-in-nanobiomedicine",title:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine",fullTitle:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine"},signatures:"Chander Amgoth, Chiuyen Phan, Murali Banavoth, Santosh Rompivalasa and Guping Tang",authors:null},{id:"67379",doi:"10.5772/intechopen.86601",title:"Breaking down the Barrier: Topical Liposomes as Nanocarriers for Drug Delivery into the Posterior Segment of the Eyeball",slug:"breaking-down-the-barrier-topical-liposomes-as-nanocarriers-for-drug-delivery-into-the-posterior-seg",totalDownloads:1290,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"Topical instillation is the most widely preferred noninvasive route of drug administration to treat diseases affecting the anterior segment of the eye. Nonetheless, the ocular bioavailability for deeper ocular tissues is very low. Different routes of administration, such as intravitreal injections, periocular injections, and systemic administration, have been used to deliver drugs into the posterior segment ocular tissues. However, the presence of blood-retinal barriers (BRBs) makes systemic administration an impractical approach, whereas the drug delivery with the periocular administration route is compromised by ocular static and dynamic barriers. On the other hand, intravitreal injection, the most common and widely recommended route for drug administration to treat posterior ocular diseases, is related to several side effects such as endophthalmitis, hemorrhage, retinal detachment, and poor patient tolerance. Diverse strategies to overcome ocular barriers have been explored for topical drop formulations in order to deliver drugs into the posterior segment ocular tissues. In this chapter, we will review the promising topical nanocarriers for drug delivery into the posterior segment of the eye, emphasizing the use of liposomes for topical ophthalmic formulations targeting the vitreous cavity and the retina.",book:{id:"7663",slug:"role-of-novel-drug-delivery-vehicles-in-nanobiomedicine",title:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine",fullTitle:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine"},signatures:"Arturo Santos, Juan C. Altamirano-Vallejo, José Navarro-Partida, Alejandro González-De la Rosa and Jane H. Hsiao",authors:null}],mostDownloadedChaptersLast30Days:[{id:"70327",title:"Solid Lipid Based Nano-particulate Formulations in Drug Targeting",slug:"solid-lipid-based-nano-particulate-formulations-in-drug-targeting",totalDownloads:957,totalCrossrefCites:2,totalDimensionsCites:6,abstract:"Recently, targeted drug delivery systems have gained much more interest for delivering varieties of drugs as well as imaging agents specifically to the targeted disease cells or tissues. These are well known for their increased precision and accuracy in mode of drug delivery along with reduced side effects. Though numerous carriers are being employed for drug targeting, the solid lipid based nanoparticles (SLNs) are preferred over them owing to their ability to encapsulate wide varieties of drugs, biocompatibility, ease of surface modification, scaling up feasibility, and possibilities of both active as well as passive targeting to various organs. Surface of these drug loaded SLNs can be modified by conjugating different ligands to enhance their tissue/organ targeting ability and therapeutic efficacy to much higher extent. In this chapter, we have discussed about the SLNs and their different surface modified forms for passive as well as active targeting to different organ such as (colon, breast, lungs, liver, kidney, brain, eyes, etc.) in combating different diseases.",book:{id:"7663",slug:"role-of-novel-drug-delivery-vehicles-in-nanobiomedicine",title:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine",fullTitle:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine"},signatures:"Bibhash Chandra Mohanta, Subas Chandra Dinda, Narahari Narayan Palei and Jyotirmoy Deb",authors:null},{id:"54825",title:"Introductory Chapter: Drug Delivery Concepts",slug:"introductory-chapter-drug-delivery-concepts",totalDownloads:2747,totalCrossrefCites:3,totalDimensionsCites:16,abstract:null,book:{id:"5357",slug:"advanced-technology-for-delivering-therapeutics",title:"Advanced Technology for Delivering Therapeutics",fullTitle:"Advanced Technology for Delivering Therapeutics"},signatures:"Sabyasachi Maiti and Kalyan Kumar Sen",authors:[{id:"180971",title:"Dr.",name:"Sabyasachi",middleName:null,surname:"Maiti",slug:"sabyasachi-maiti",fullName:"Sabyasachi Maiti"}]},{id:"70083",title:"Drug Delivery through Targeted Approach with Special References to Phytosomes",slug:"drug-delivery-through-targeted-approach-with-special-references-to-phytosomes",totalDownloads:896,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Novel drug delivery is a great tool to deliver the drug at a specific site of action by the means of specific drug carrier like Solid-lipid Nanoparticles, Nano-structured lipid carriers, lipid vesicles, liposomes, phytosomes and ethosomes. Every carrier used in novel drug delivery system to deliver the drug at targeted site requires some special formulation techniques. These techniques help the drug carrier to deliver the active drug at targeted site, by reducing the side-effect, minimizing the dose, increasing the absorption and increasing the efficacy of the drug. There is a recent upsurge to move “back to nature” for healing body ailments because the report states that conventional treatment cause various side effects to the human body after prolonged used. Various novel drug delivery vesicles/‘somes’ are being used for the delivery of phytoconstitutents to the targeted site of action. Phytosome is one of the more reliable and best option for the delivery of herbal constituent to the targeted site. The combination of Novel drug delivery with the transdermal route may be a good idea having fast and targeted delivery of drug. Many health challenges like skin diseases, skin burns, migraine, allergies, cardiac problems, diabetes and trauma like bone fracture could be easily managed by the combination of novel drug delivery and the transdermal route in future.",book:{id:"7663",slug:"role-of-novel-drug-delivery-vehicles-in-nanobiomedicine",title:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine",fullTitle:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine"},signatures:"Mahendra Rana, Aadesh Kumar and Amita J. Rana",authors:null},{id:"67379",title:"Breaking down the Barrier: Topical Liposomes as Nanocarriers for Drug Delivery into the Posterior Segment of the Eyeball",slug:"breaking-down-the-barrier-topical-liposomes-as-nanocarriers-for-drug-delivery-into-the-posterior-seg",totalDownloads:1289,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"Topical instillation is the most widely preferred noninvasive route of drug administration to treat diseases affecting the anterior segment of the eye. Nonetheless, the ocular bioavailability for deeper ocular tissues is very low. Different routes of administration, such as intravitreal injections, periocular injections, and systemic administration, have been used to deliver drugs into the posterior segment ocular tissues. However, the presence of blood-retinal barriers (BRBs) makes systemic administration an impractical approach, whereas the drug delivery with the periocular administration route is compromised by ocular static and dynamic barriers. On the other hand, intravitreal injection, the most common and widely recommended route for drug administration to treat posterior ocular diseases, is related to several side effects such as endophthalmitis, hemorrhage, retinal detachment, and poor patient tolerance. Diverse strategies to overcome ocular barriers have been explored for topical drop formulations in order to deliver drugs into the posterior segment ocular tissues. 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Aptamers are comparable to monoclonal antibodies, which are well-established therapeutic molecules, in terms of specificity and affinity to their target. The advantage of aptamers over antibodies includes their high stability, ease of synthesis, less batch-to-batch variation, easy chemical modifications that allow different conjugation chemistries, small size for better tissue penetration and low immunogenicity. These advantages make aptamers an important tool for use in therapeutics for targeted delivery. However, aptamers do have some limitations that have hindered their widespread clinical use as a therapeutic agent. Some of their common limitations include serum stability, renal filtration and endocytic escape. Other limitations that are more specific to aptamers include lack of diversity in the aptamer library, nuclease susceptibility and claims of aptamer specificity as well. This book chapter sheds light on these challenges, and using examples, it explains the scientific advancements that have been achieved in overcoming these limitations. We will end this chapter by discussing the use of high-throughput technology, which is the only way of truly industrializing the aptamer technology akin to the development of small molecule drugs.",book:{id:"7663",slug:"role-of-novel-drug-delivery-vehicles-in-nanobiomedicine",title:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine",fullTitle:"Role of Novel Drug Delivery Vehicles in Nanobiomedicine"},signatures:"Chetan Chandola and Muniasamy Neerathilingam",authors:null}],onlineFirstChaptersFilter:{topicId:"1194",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. 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He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. 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Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. 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He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. 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\r\n\tThe integration of tissues and organs throughout the mammalian body, as well as the expression, structure, and function of molecular and cellular components, is essential for modern physiology. The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
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He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},onlineFirstChapters:{paginationCount:9,paginationItems:[{id:"83075",title:"Practices and Challenges of Community Services at Debre Markos University, Ethiopia: A Case Study",doi:"10.5772/intechopen.105896",signatures:"Adane Mengist",slug:"practices-and-challenges-of-community-services-at-debre-markos-university-ethiopia-a-case-study",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82858",title:"Corporate Social Responsibility a Case of the Provision of Recreational Facilities",doi:"10.5772/intechopen.105608",signatures:"Peter Musa Wash, Shida Irwana Omar, Badaruddin Mohamed and Mohd Ismail Isa",slug:"corporate-social-responsibility-a-case-of-the-provision-of-recreational-facilities",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? 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