The file formats and transfer interfaces from CAD to ADAMS.
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Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6302",leadTitle:null,fullTitle:"Herbal Medicine",title:"Herbal Medicine",subtitle:null,reviewType:"peer-reviewed",abstract:"Herbal medicine is a multidisciplinary compilation of topics in herbal medicine that are designed to enlighten all who have a stake in healthcare. In light of the current trends and popularity of herbal medicine, cultural/societal differences and perception, and the relationship with modern healthcare this book presents selected topics to ensure that necessary information on herbal medicine in healthcare is provided. Apart from clarifying certain important complexities and misconceptions on herbal medicine, a general overview of herbal medicine, uses of herbs in the management of diseases, plant secondary metabolites, analytical techniques, applications in stem cell research, use as leads for conventional drug compound development, and research and development of herbal medicines for healthcare are among the major discussions in this book.",isbn:"978-1-78984-783-3",printIsbn:"978-1-78984-782-6",pdfIsbn:"978-1-83881-386-4",doi:"10.5772/intechopen.69412",price:139,priceEur:155,priceUsd:179,slug:"herbal-medicine",numberOfPages:314,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"b70a98c6748d0449a6288de73da7b8d9",bookSignature:"Philip F. Builders",publishedDate:"January 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6302.jpg",numberOfDownloads:48669,numberOfWosCitations:137,numberOfCrossrefCitations:129,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:287,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:553,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 23rd 2017",dateEndSecondStepPublish:"June 13th 2017",dateEndThirdStepPublish:"September 9th 2017",dateEndFourthStepPublish:"December 8th 2017",dateEndFifthStepPublish:"February 6th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"182744",title:"Dr.",name:"Philip",middleName:null,surname:"Builders",slug:"philip-builders",fullName:"Philip Builders",profilePictureURL:"https://mts.intechopen.com/storage/users/182744/images/5533_n.jpg",biography:"Dr. Philip Fafowora Builder is a Nigerian born on 12th February 1968 in Ibadan. He attended Baptist Day Primary School Jos and Command Secondary School Jos, Plateau State Nigeria. He obtained the Bachelor of Pharmacy degree (B. Pharm.) from the University of Jos, in 1991 and, Master of Pharmacy (M. Pharm) and Doctor of Philosophy (Ph. D- Pharmaceutics) degrees from University of Nigeria, Nsukka, Enugu State, Nigeria in 1997 and 2008 respectively. He worked as a research fellow in the Department of Pharmaceutical Technology and Raw Materials Development (NIPRD), Abuja, Nigeria from 2002 to 2016. His is currently an Associate Professor and the Head of Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna State, Nigeria. He has published several research articles and review papers in many peer review journals as well as book chapters. He has also received several academic awards among which are: Best Graduating Student Forensic Pharmacy, University of Jos, Nigeria 1991; University of Nigeria Vice Chancellor’s Price for Best Ph. D Student, Department of Pharmaceutics, 2008. His areas of research interest are: development of novel biopolymers for drug delivery, dosage form design of conventional drugs and herbal medicines, nano-particulate drug delivery systems, stability and quality assessment of herbal medicines and conventional drugs.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"991",title:"Herbalism",slug:"herbalism"}],chapters:[{id:"62180",title:"Introductory Chapter: Introduction to Herbal Medicine",doi:"10.5772/intechopen.78661",slug:"introductory-chapter-introduction-to-herbal-medicine",totalDownloads:2416,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Philip F. Builders",downloadPdfUrl:"/chapter/pdf-download/62180",previewPdfUrl:"/chapter/pdf-preview/62180",authors:[{id:"182744",title:"Dr.",name:"Philip",surname:"Builders",slug:"philip-builders",fullName:"Philip Builders"}],corrections:null},{id:"61866",title:"Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants",doi:"10.5772/intechopen.76139",slug:"plants-secondary-metabolites-the-key-drivers-of-the-pharmacological-actions-of-medicinal-plants",totalDownloads:8878,totalCrossrefCites:56,totalDimensionsCites:140,hasAltmetrics:1,abstract:"The vast and versatile pharmacological effects of medicinal plants are basically dependent on their phytochemical constituents. Generally, the phytochemical constituents of plants fall into two categories based on their role in basic metabolic processes, namely primary and secondary metabolites. Primary plant metabolites are involved in basic life functions; therefore, they are more or less similar in all living cells. On the other hand, secondary plant metabolites are products of subsidiary pathways as the shikimic acid pathway. In the course of studying, the medicinal effect of herbals is oriented towards the secondary plant metabolites. Secondary plant metabolites played an important role in alleviating several aliments in the traditional medicine and folk uses. In modern medicine, they provided lead compounds for the production of medications for treating various diseases from migraine up to cancer. Secondary plant metabolites are classified according to their chemical structures into various classes. In this chapter, we will be presenting various classes of secondary plant metabolites, their distribution in different plant families and their important medicinal uses.",signatures:"Rehab A. Hussein and Amira A. El-Anssary",downloadPdfUrl:"/chapter/pdf-download/61866",previewPdfUrl:"/chapter/pdf-preview/61866",authors:[{id:"212117",title:"Dr.",name:"Rehab",surname:"Hussein",slug:"rehab-hussein",fullName:"Rehab Hussein"},{id:"221140",title:"Dr.",name:"Amira",surname:"El-Anssary",slug:"amira-el-anssary",fullName:"Amira El-Anssary"}],corrections:null},{id:"59405",title:"Ergastic Crystal Studies for Raw Drug Analysis",doi:"10.5772/intechopen.74278",slug:"ergastic-crystal-studies-for-raw-drug-analysis",totalDownloads:1161,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Phytochemical constituents are distributed in various parts of plants and their localization is indicative of their therapeutic properties. Ergastic crystals such as calcium oxalate crystals are also found in almost all plant parts, which is an anti–nutrient as the dietary oxalates contributes to human ailments. Several of the medicinally useful plants contain these crystals and consumption of such plant materials in raw form can cause health problems in humans. Ergastic crystals can be an important diagnostic tool for the identification of raw drug as in Costus pictus a medicinal spiral ginger commonly called Insulin plant is devoid of cuboidal crystal but its related Costus speciosus leaves possess characteristic cuboidal shaped crystal in its leaf mesophyll. Gene manipulation technology may be promising in removing such deleterious genes or introduction of altered bio-chemicals to nullify such effects for the future generation.",signatures:"Thara K. Simon and Justin R. Nayagam",downloadPdfUrl:"/chapter/pdf-download/59405",previewPdfUrl:"/chapter/pdf-preview/59405",authors:[{id:"211486",title:"Dr.",name:"Justin",surname:"R Nayagam",slug:"justin-r-nayagam",fullName:"Justin R Nayagam"},{id:"220837",title:"Dr.",name:"Thara",surname:"K Simon",slug:"thara-k-simon",fullName:"Thara K Simon"}],corrections:null},{id:"58422",title:"Guidelines for the Development of Herbal-Based Sunscreen",doi:"10.5772/intechopen.72712",slug:"guidelines-for-the-development-of-herbal-based-sunscreen",totalDownloads:1566,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Sun protection is a complex topic, which involves various classes of compounds. The photoprotective effectiveness of a sunscreen involves many biological activities, such as ultraviolet (UV) radiation filter properties and antioxidant, anti-inflammatory, and antimutagenic effects. Formulation strategy is also a key factor. Several studies have examined the role of natural molecules as photoprotective compounds, and a considerable number of commercially available sunscreens contain herbal extracts but not as sunfilters. Indeed, the process of evaluation of UV-filtering and photoprotective activity of herbal compounds presents certain specific difficulties and needs in vitro and in vivo studies. Nowadays, no natural compound or vegetal extract has been approved by any country as official UV filter for sunscreen. With these premises, the aim of this chapter is to define a set of tests, which can help to evaluate the efficacy of an herbal extract in the field of sun protection; in other words, we propose a rational approach to the discovery of natural UV-filtering extract and molecules. The following electronic databases have been used as a source of information: SciFinder, PubMed, Google Scholar, ISI-Web of Science, and Scopus.",signatures:"Piergiacomo Buso, Matteo Radice, Anna Baldisserotto, Stefano\nManfredini and Silvia Vertuani",downloadPdfUrl:"/chapter/pdf-download/58422",previewPdfUrl:"/chapter/pdf-preview/58422",authors:[{id:"212100",title:"Prof.",name:"Stefano",surname:"Manfredini",slug:"stefano-manfredini",fullName:"Stefano Manfredini"},{id:"212101",title:"BSc.",name:"Piergiacomo",surname:"Buso",slug:"piergiacomo-buso",fullName:"Piergiacomo Buso"},{id:"212102",title:"Prof.",name:"Matteo",surname:"Radice",slug:"matteo-radice",fullName:"Matteo Radice"},{id:"212103",title:"Prof.",name:"Silvia",surname:"Vertuani",slug:"silvia-vertuani",fullName:"Silvia Vertuani"},{id:"220809",title:"Dr.",name:"Anna",surname:"Baldisserotto",slug:"anna-baldisserotto",fullName:"Anna Baldisserotto"}],corrections:null},{id:"58270",title:"Toxicity and Safety Implications of Herbal Medicines Used in Africa",doi:"10.5772/intechopen.72437",slug:"toxicity-and-safety-implications-of-herbal-medicines-used-in-africa",totalDownloads:3380,totalCrossrefCites:16,totalDimensionsCites:39,hasAltmetrics:1,abstract:"The use of herbal medicines has seen a great upsurge globally. In developing countries, many patronize them largely due to cultural acceptability, availability and cost. In developed countries, they are used because they are natural and therefore assumed to be safer than allopathic medicines. In recent times, however, there has been a growing concern about their safety. This has created a situation of ambivalence in discussions regarding their use. Some medicinal plants are intrinsically toxic by virtue of their constituents and can cause adverse reactions if inappropriately used. Other factors such as herb-drug interactions, lack of adherence to good manufacturing practice (GMP), poor regulatory measures and adulteration may also lead to adverse events in their use. Many in vivo tests on aqueous extracts largely support the safety of herbal medicines, whereas most in vitro tests on isolated single cells mostly with extracts other than aqueous ones show contrary results and thus continue the debate on herbal medicine safety. It is expected that toxicity studies concerning herbal medicine should reflect their traditional use to allow for rational discussions regarding their safety for their beneficial use. While various attempts continue to establish the safety of various herbal medicines in man, their cautious and responsible use is required.",signatures:"Merlin L.K. Mensah, Gustav Komlaga, Arnold D. Forkuo, Caleb\nFirempong, Alexander K. Anning and Rita A. Dickson",downloadPdfUrl:"/chapter/pdf-download/58270",previewPdfUrl:"/chapter/pdf-preview/58270",authors:[{id:"190435",title:"Dr.",name:"Caleb",surname:"Firempong",slug:"caleb-firempong",fullName:"Caleb Firempong"},{id:"212111",title:"Dr.",name:"Gustav",surname:"Komlaga",slug:"gustav-komlaga",fullName:"Gustav Komlaga"},{id:"217045",title:"Dr.",name:"Arnold Forkuo",surname:"Donkor",slug:"arnold-forkuo-donkor",fullName:"Arnold Forkuo Donkor"},{id:"217049",title:"Prof.",name:"Merlin Lincoln Kwao",surname:"Mensah",slug:"merlin-lincoln-kwao-mensah",fullName:"Merlin Lincoln Kwao Mensah"},{id:"217488",title:"Dr.",name:"Alexander K.",surname:"Anning",slug:"alexander-k.-anning",fullName:"Alexander K. Anning"},{id:"223959",title:"Prof.",name:"Akosua Rita",surname:"Dickson",slug:"akosua-rita-dickson",fullName:"Akosua Rita Dickson"}],corrections:null},{id:"58431",title:"Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells",doi:"10.5772/intechopen.72711",slug:"application-of-herbal-medicine-as-proliferation-and-differentiation-effectors-of-human-stem-cells",totalDownloads:1647,totalCrossrefCites:1,totalDimensionsCites:6,hasAltmetrics:0,abstract:"One of the main streams of traditional medicine is herbal medicine; a wide range of medicinal plants and their individual parts are used for therapy. Though not scientifically validated, this traditional medicine practice is much popular in countries such as India, China and Sri Lanka and in many other countries in South, Southeast and Eastern Asia due mainly to its healing capabilities. More recently, scientists initiated the chemical analyses of these medicinal plants, obtaining invaluable results. The latest addition to such investigations is studies on effects of herbal extracts on different types of stem cells. An extensive summary of such reported studies is presented in this chapter, mainly categorizing these into proliferation stimulatory effects on stem cells and inhibitory effects on cancer stem cells (CSCs), where both properties are beneficial in cell therapy procedures. At present, standardizing the products and limited knowledge on the mechanisms of action and pathways of these have critically limited the use of herbal extracts in therapeutics. However, we believe that in the near future scientists would be focusing on herbal remedies to replace the use of synthetic stimulants and cancer drugs to overcome the disadvantages of these, such as toxicity, side effects and exorbitant costs.",signatures:"Preethi Vidya Udagama and Vindya Udalamaththa",downloadPdfUrl:"/chapter/pdf-download/58431",previewPdfUrl:"/chapter/pdf-preview/58431",authors:[{id:"181671",title:"Prof.",name:"Preethi",surname:"Udagama",slug:"preethi-udagama",fullName:"Preethi Udagama"},{id:"214245",title:"Ms.",name:"Vindya",surname:"Udalamaththa",slug:"vindya-udalamaththa",fullName:"Vindya Udalamaththa"}],corrections:null},{id:"61138",title:"Herbal Medicine Use during Pregnancy: Benefits and Untoward Effects",doi:"10.5772/intechopen.76896",slug:"herbal-medicine-use-during-pregnancy-benefits-and-untoward-effects",totalDownloads:4203,totalCrossrefCites:6,totalDimensionsCites:13,hasAltmetrics:0,abstract:"The use of herbal medicine has been on an increase over time. The most commonly used herbs are ginger, cranberry, valerian, raspberry leaf, chamomile, peppermint, thyme, fenugreek, green tea, sage, anise, garlic and bitter kola. The use of herbal medicine during pregnancy is associated with educational status of women, income level of household and age of women. Herbal medicines were used during pregnancy to treat nausea and vomiting, reduce the risk of preeclampsia, shorten labour and treat common cold and urinary tract infection. Using herbal medicine occasionally causes trouble. Heartburn, pre-mature labour, miscarriage, increase in blood flow, abortion and allergic reactions are the common troubles of herbal medicine use during pregnancy. Using herbal medicine during the first trimester and the third trimester is unsafe for the foetus. Pregnant women should talk to health professionals before consuming any herbal medicines. The unfortunate consequences of using herbal medicine during pregnancy need further study for various herbs. Therefore, clinical trial research should be done to identify unfortunate consequences of herbal medicine use during pregnancy.",signatures:"Tariku Laelago",downloadPdfUrl:"/chapter/pdf-download/61138",previewPdfUrl:"/chapter/pdf-preview/61138",authors:[{id:"211130",title:null,name:"Tariku",surname:"Ersado",slug:"tariku-ersado",fullName:"Tariku Ersado"}],corrections:null},{id:"58513",title:"Plant-Derived Medicines with Potential Use in Wound Treatment",doi:"10.5772/intechopen.72813",slug:"plant-derived-medicines-with-potential-use-in-wound-treatment",totalDownloads:2661,totalCrossrefCites:7,totalDimensionsCites:12,hasAltmetrics:1,abstract:"The skin is among the largest and one of the most important organs in the human body. It represents the first line of defence of the body; provides protection from mechanical impacts of the environment, limits the influence of variations in the temperature, prevents entrance of chemicals and microorganisms and restricts radiation effect. Skin damage affects all skin functions; therefore, wounds can compromise patient’s well-being, self-image, working capacity and independence. Due to all mentioned, a good wound management is necessary not only for the individual but also for the community. Herbal medicines have been used to accelerate wound healing since ancient times. Recently, scientists have been able to employ scientific methods to prove efficacy of many of these herbs and to get a better understanding of mechanisms of their actions. The popularity of herbal medicines may be explained by the perception that herbs cause minimal adverse effects. Preparations from traditional medicinal plants in wound management involve disinfection, debridement and the provision of suitable environment for natural healing process. In this chapter, the field of wound healing is briefly introduced. Further, the crucial information regarding plants, which are effectively used as wound healing agents in traditional medicine are gathered.",signatures:"Tina Maver, Manja Kurečič, Dragica Maja Smrke, Karin Stana\nKleinschek and Uroš Maver",downloadPdfUrl:"/chapter/pdf-download/58513",previewPdfUrl:"/chapter/pdf-preview/58513",authors:[{id:"142060",title:"Prof.",name:"Uroš",surname:"Maver",slug:"uros-maver",fullName:"Uroš Maver"},{id:"175361",title:"Dr.",name:"Karin",surname:"Stana Kleinschek",slug:"karin-stana-kleinschek",fullName:"Karin Stana Kleinschek"},{id:"227392",title:"Dr.",name:"Tina",surname:"Maver",slug:"tina-maver",fullName:"Tina Maver"},{id:"227393",title:"Prof.",name:"Manja",surname:"Kurečič",slug:"manja-kurecic",fullName:"Manja Kurečič"},{id:"227394",title:"Prof.",name:"Dragica Maja",surname:"Smrke",slug:"dragica-maja-smrke",fullName:"Dragica Maja Smrke"}],corrections:null},{id:"58115",title:"Plant-Based Ethnopharmacological Remedies for Hypertension in Suriname",doi:"10.5772/intechopen.72106",slug:"plant-based-ethnopharmacological-remedies-for-hypertension-in-suriname",totalDownloads:1752,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Hypertension is the most important modifiable risk factor for cardiovascular, cerebrovascular, and renal diseases which are together among the most frequent causes of morbidity and mortality in the world. Despite the availability of a wide range of effective medicines, many individuals suffering from hypertension use plant-derived preparations for treating their disease. The choice for these alternatives is often associated with the closer relationship of such approaches to specific social, cultural, and religious perceptions about health and disease. However, in most cases, the scientific evidence for clinical efficacy of such medications is scant. The Republic of Suriname is a middle-income country in South America with a relatively high prevalence of hypertension and other cardiovascular diseases. This country harbors descendants of all continents, all of whom have preserved their cultural customs including their ethnopharmacological traditions. As a result, many Surinamese are inclined to treat their diseases including hypertension as they have done for centuries, that is, with plant-based preparations. This chapter has compiled the plants used for treating hypertension in Suriname; extensively evaluates 15 commonly used plants for potential efficacy on the basis of available phytochemical, mechanistic, preclinical, and clinical literature data; and closes with conclusions about their potential usefulness against the disease.",signatures:"Dennis R.A. Mans, Angela Grant and Nicholaas Pinas",downloadPdfUrl:"/chapter/pdf-download/58115",previewPdfUrl:"/chapter/pdf-preview/58115",authors:[{id:"193905",title:"Dr.",name:"Dennis",surname:"R.A. Mans",slug:"dennis-r.a.-mans",fullName:"Dennis R.A. Mans"},{id:"219349",title:"BSc.",name:"Angela",surname:"Grant",slug:"angela-grant",fullName:"Angela Grant"},{id:"224838",title:"MSc.",name:"Nicholaas",surname:"Pinas",slug:"nicholaas-pinas",fullName:"Nicholaas Pinas"}],corrections:null},{id:"64851",title:"Herbal Medicines in African Traditional Medicine",doi:"10.5772/intechopen.80348",slug:"herbal-medicines-in-african-traditional-medicine",totalDownloads:14210,totalCrossrefCites:30,totalDimensionsCites:52,hasAltmetrics:1,abstract:"African traditional medicine is a form of holistic health care system organized into three levels of specialty, namely divination, spiritualism, and herbalism. The traditional healer provides health care services based on culture, religious background, knowledge, attitudes, and beliefs that are prevalent in his community. Illness is regarded as having both natural and supernatural causes and thus must be treated by both physical and spiritual means, using divination, incantations, animal sacrifice, exorcism, and herbs. Herbal medicine is the cornerstone of traditional medicine but may include minerals and animal parts. The adjustment is ok, but may be replaced with –‘ Herbal medicine was once termed primitive by western medicine but through scientific investigations there is a better understanding of its therapeutic activities such that many pharmaceuticals have been modeled on phytochemicals derived from it. Major obstacles to the use of African medicinal plants are their poor quality control and safety. Traditional medical practices are still shrouded with much secrecy, with few reports or documentations of adverse reactions. However, the future of African traditional medicine is bright if viewed in the context of service provision, increase of health care coverage, economic potential, and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will hold much promise for the future.",signatures:"Ezekwesili-Ofili Josephine Ozioma and Okaka Antoinette Nwamaka\nChinwe",downloadPdfUrl:"/chapter/pdf-download/64851",previewPdfUrl:"/chapter/pdf-preview/64851",authors:[{id:"191264",title:"Prof.",name:"Josephine",surname:"Ezekwesili-Ofili",slug:"josephine-ezekwesili-ofili",fullName:"Josephine Ezekwesili-Ofili"},{id:"211585",title:"Prof.",name:"Antoinette",surname:"Okaka",slug:"antoinette-okaka",fullName:"Antoinette Okaka"}],corrections:null},{id:"59484",title:"Herbal Medicine",doi:"10.5772/intechopen.72816",slug:"herbal-medicine",totalDownloads:2397,totalCrossrefCites:5,totalDimensionsCites:9,hasAltmetrics:0,abstract:"Herbal medicine has gained cumulative popularity in today’s medical practice. These treatments are the synthesis of therapeutic experiences of generations of traditional physicians for over hundreds of years. However, most of these applications are unorthodox, with over 80% of the world’s population depending on some form of traditional medicine. The increase in the use of herbal products is due to their cultural acceptability, availability, affordability, efficacy and safety claims. This upsurge has led to the improvements in the quality and analysis of herbal products to be made with clinical research advancements in their safety and efficacy. The World Health Organization has recognized the importance of herbal medicine to the health of many people. Therefore, developing guidelines to evaluate herbal medicine by using modern control procedures and applying suitable standards. The current review aims to describe the present state and the projected future of herbal medicine.",signatures:"Nontokozo Z. Msomi and Mthokozisi B.C. Simelane",downloadPdfUrl:"/chapter/pdf-download/59484",previewPdfUrl:"/chapter/pdf-preview/59484",authors:[{id:"193091",title:"Dr.",name:"Mthokozisi",surname:"Simelane",slug:"mthokozisi-simelane",fullName:"Mthokozisi Simelane"},{id:"195504",title:"Ms.",name:"Nontokozo",surname:"Msomi",slug:"nontokozo-msomi",fullName:"Nontokozo Msomi"}],corrections:null},{id:"58960",title:"Powerful Properties of Ozonated Extra Virgin Olive Oil",doi:"10.5772/intechopen.73211",slug:"powerful-properties-of-ozonated-extra-virgin-olive-oil",totalDownloads:1778,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Extra virgin olive oil has been mainly produced and consumed in Mediterranean countries since ancient times; olive oil is one of the principal ingredients in the Mediterranean diet, and it constitutes the main source of nutritional fat. Aside from the high nutritional content of olive oil, it is also known for its cosmetic and therapeutic properties. In 1956, Thiers obtained satisfactory results in the treatment of scleroderma, stating that olive oil and its derivatives could be considered “a new group of therapeutic agents.” Hincky reported the beneficial properties of olive oil in the treatment of dry, senescent and sensitive skins. This has opened a new perspective for the use of the olive fruit, thus contributing to the increase in research about new applications. One such application is ozonized olive oil, which combines the properties of ozone with those of olive oil, to obtain a peerless compound. The composition of olive oil makes it a suitable vehicle for cutaneous absorption, as it is able to stabilize ozone, which is a highly reactive molecule. The oxidant power of ozone has interesting effects on microorganism and on wound healing.",signatures:"Elisabetta Carata, Bernardetta Anna Tenuzzo and Luciana Dini",downloadPdfUrl:"/chapter/pdf-download/58960",previewPdfUrl:"/chapter/pdf-preview/58960",authors:[{id:"103116",title:"Prof.",name:"Luciana",surname:"Dini",slug:"luciana-dini",fullName:"Luciana Dini"},{id:"206595",title:"Dr.",name:"Bernardetta Anna",surname:"Tenuzzo",slug:"bernardetta-anna-tenuzzo",fullName:"Bernardetta Anna Tenuzzo"},{id:"206596",title:"Dr.",name:"Elisabetta",surname:"Carata",slug:"elisabetta-carata",fullName:"Elisabetta Carata"}],corrections:null},{id:"58339",title:"Taraxacum Genus: Potential Antibacterial and Antifungal Activity",doi:"10.5772/intechopen.71619",slug:"taraxacum-genus-potential-antibacterial-and-antifungal-activity",totalDownloads:1689,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Plants have been used in traditional medicine for centuries as antibacterial and antifungal agents. Taraxacum spp., commonly known as dandelion, is a well-known herbal remedy with a long history; however, limited scientific information is available to explain its traditional use. This review aims to provide current information and a general overview of the available literature concerning the antibacterial and antifungal properties of the Taraxacum genus to support its potential as a powerful herbal medicine. Though Taraxacum has demonstrated that it is capable of inhibiting the growth of a wide range of bacteria and fungi, the technical aspects of methodology lack standardization, and, therefore, the overall results of processing are difficult to compare between studies. Phytochemical composition and antimicrobial activity in Taraxacum are neither directly related, nor does the published data provide sufficient information for identifying the group of unique extraction conditions that are optimal against specific microorganisms. Antimicrobial research indicates that this plant is a promising species for treating several common infections in humans, animals, and plants.",signatures:"María Eugenia Martínez Valenzuela, Katy Díaz Peralta, Lorena\nJorquera Martínez and Rolando Chamy Maggi",downloadPdfUrl:"/chapter/pdf-download/58339",previewPdfUrl:"/chapter/pdf-preview/58339",authors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"},{id:"219869",title:"MSc.",name:"María Eugenia",surname:"Martínez",slug:"maria-eugenia-martinez",fullName:"María Eugenia Martínez"},{id:"219871",title:"Dr.",name:"Katy",surname:"Díaz",slug:"katy-diaz",fullName:"Katy Díaz"},{id:"219872",title:"Dr.",name:"Lorena",surname:"Jorquera",slug:"lorena-jorquera",fullName:"Lorena Jorquera"}],corrections:null},{id:"58560",title:"Taraxacum Genus: Extract Experimental Approaches",doi:"10.5772/intechopen.72849",slug:"taraxacum-genus-extract-experimental-approaches",totalDownloads:935,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter presents factors or considerations to be taken into account when selecting the procedure or method for obtaining extracts and bioactive compounds. The genus Taraxacum has proved to have several interesting properties and there are numerous techniques and bioassays used to test the antimicrobial properties of extracts. However, the extraction process is crucial to optimize the final biological outcomes. Extraction procedures that until now have been used are simple and inexpensive, however, we wanted to report a series of studies that group valuable results, which could be useful for future studies, enhancing the research carried out by authors from all over the world and also allowing the interrelated study of this genus.",signatures:"María Eugenia Martínez Valenzuela, Katy Díaz Peralta, Lorena\nJorquera Martínez and Rolando Chamy Maggi",downloadPdfUrl:"/chapter/pdf-download/58560",previewPdfUrl:"/chapter/pdf-preview/58560",authors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"542",title:"A Compendium of Essays on Alternative Therapy",subtitle:null,isOpenForSubmission:!1,hash:"a805c1d2d8449dcecd52eb7a48d2e6b1",slug:"a-compendium-of-essays-on-alternative-therapy",bookSignature:"Arup Bhattacharya",coverURL:"https://cdn.intechopen.com/books/images_new/542.jpg",editedByType:"Edited by",editors:[{id:"66982",title:"Dr.",name:"Arup",surname:"Bhattacharya",slug:"arup-bhattacharya",fullName:"Arup Bhattacharya"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"631",title:"Quality Control of Herbal Medicines and Related Areas",subtitle:null,isOpenForSubmission:!1,hash:"5ced81d454b4a5ded2a0aa02e0d7621d",slug:"quality-control-of-herbal-medicines-and-related-areas",bookSignature:"Yukihiro Shoyama",coverURL:"https://cdn.intechopen.com/books/images_new/631.jpg",editedByType:"Edited by",editors:[{id:"35812",title:"Prof.",name:"Yukihiro",surname:"Shoyama",slug:"yukihiro-shoyama",fullName:"Yukihiro Shoyama"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"643",title:"Recent Advances in Theories and Practice of Chinese Medicine",subtitle:null,isOpenForSubmission:!1,hash:"499a7fabf489d2502de4616a4c7f3da0",slug:"recent-advances-in-theories-and-practice-of-chinese-medicine",bookSignature:"Haixue Kuang",coverURL:"https://cdn.intechopen.com/books/images_new/643.jpg",editedByType:"Edited by",editors:[{id:"44740",title:"Prof.",name:"Haixue",surname:"Kuang",slug:"haixue-kuang",fullName:"Haixue Kuang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5612",title:"Aromatic and Medicinal Plants",subtitle:"Back to Nature",isOpenForSubmission:!1,hash:"ccf7987200bfc541e2e56bb138de86f3",slug:"aromatic-and-medicinal-plants-back-to-nature",bookSignature:"Hany A. 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From 2008 to 2012, he worked as a postdoctoral research associate in the field of Brain-Machine Interfaces (BMI) to control prostheses at the School of Medicine, the University of Pittsburgh, where he received the Mary E Switzer Merit Fellowship from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) in 2010. From 2012 to 2013, he worked as a research assistant professor in the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, in the area of neuroprosthetics. He also worked as an assistant professor in the Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey, from 2013 to 2020. He holds a secondary appointment as an adjunct assistant Professor at the Indian Institute of Technology, Hyderabad, India. He is currently an assistant professor in the Department of Computer Science and Electrical Engineering, University of Maryland, USA.\n\nIn 2018, Dr. Vinjamuri received the Harvey N Davis Distinguished Teaching Award for excellence in undergraduate and graduate teaching. He also received the National Science Foundation (NSF) CAREER Award in 2019 and an NSF Industry-University Cooperative Research Centers (IUCRC) Planning Grant in 2020. 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The computer is currently used from the concept elaboration stage until the manufacturing and implementation. Designers now have access to very sophisticated and high-performance working tools, based on software solutions dedicated to the various stages of product design and development. The traditional computer-aided design (CAD) and computer-aided manufacturing (CAM) approaches are now being addressed through computer-aided engineering (CAE) integrating platforms, which allow the evaluation and improvement of the product at the system level and not separately on its parts or subsystems, such an approach being reflected in increasingly efficient and competitive products [1, 2].
As the complexity and the competitiveness requirements of the products (in this case, mechanical and mechatronic systems) increase, the design and development times must be reduced, conditions in which the development and testing of physical prototypes become major impediments. Thus, it is necessary to implement design techniques based on modeling, simulation, and optimization in virtual environment, which can ensure a higher performance and quality of the products using only a fraction of the time and cost required in traditional approaches. Virtual prototyping is a computer-aided engineering-based discipline that entails modeling products, simulating and optimizing their behavior under real-world operating conditions. Through the use of various types of software solutions for evaluating the form, functionality, and durability of the products in an integrated approach, complex digital prototypes can be created and then used in virtual experiments (lab and field tests) in a similar way to the real cases [3, 4, 5].
In this context, the chapter proposes to present the integrated concept of modeling, simulation, and optimization of the behavior of mechanical and mechatronic systems through the use of a virtual prototyping software platform. The platform integrates specific software solutions for evaluating the form, assembly, functionality, and durability of mechanical and mechatronic systems. The components of the virtual prototyping platform are depicted by mentioning their particular role, as well as the mode in which they are integrated within the platform and communicate (data transfer) with each other. Then, the virtual prototyping stages are discussed starting from a flowchart reflecting the mode in which the data are transferred from one stage to another, to obtain a valid and optimal virtual prototype, these being the two attributes that the virtual prototype must have in order to be a truly useful/viable one. Finally, a case study is developed by considering a complex product, namely, a suspension system for motor vehicles, which is approached in mechatronic concept, by integrating the two main subsystems (the mechanical and actuating and control devices) at the virtual prototype level.
In the general case, the virtual prototyping platform of the mechanical systems integrates three basic software solutions (Figure 1a): computer-aided design, multibody systems (MBS), and finite element analysis (FEA). In addition, in the case of mechatronic systems (mechanical systems with controlled actuation), the virtual prototyping platform integrates a design for control (DFC) software solution (Figure 1b), in the concurrent engineering concept (for the purpose of co-simulation).
The virtual prototyping software platform for mechanical (a) and mechatronic (b) systems.
Firstly, with the help of CAD software, the geometrical (solid) 3D model of the mechanical system is developed, with the purpose to determine the mass and inertia properties (moments and products of inertia) of the bodies (rigid parts). The 3D model is then transferred to the MBS software, which is intended to analyze and optimize the behavior of the mechanical system (in terms of kinematics, statics, and dynamics, by case). The data transfer from CAD to MBS is performed using standard geometry file formats, such as STEP, IGES, Parasolid, stereolithography, and others. From this point of view, there are no rules, but only certain recommendations of the software producers regarding the file format. For example, the recommended geometry transfer formats from the main CAD software to the MBS environment Automatic Dynamic Analysis of Mechanical Systems (ADAMS) of MSC Software (which is a global leader in virtual prototyping software and services) are presented in Table 1. With such file formats, the import into ADAMS is done through the general ADAMS/Exchange transfer interface. At the same time, specialized modules (interfaces) for geometry transfer were developed, which perform a customized transfer between the CAD and MBS ADAMS environments, as it is also presented in Table 1 [6].
CAD software | File formats | Transfer interfaces |
---|---|---|
Unigraphics (UG) | Parasolid STL | UG/Mechanism |
CATIA | STL STEP IGES | CAT/ADAMS |
Pro/ENGINEER (currently Creo Elements/Pro) | STL IGES | MECHANISM/Pro |
SOLIDWORKS | Parasolid STL IGES | Dynamic Designer |
I-DEAS | STL IGES | Mechanism Design Mechanism Simulation |
Mechanical Desktop | IGS STL DXF | Dynamic Designer |
The file formats and transfer interfaces from CAD to ADAMS.
Initial Graphics Exchange Specification (IGES) format represents the first standard of interchangeability, being designed in American Standard Code for Information Interchange (ASCII) code. IGES reduces the CAD model to a list of entities, each entity being associated with a number. Drawing Exchange Format (DXF) is also based on graphical entities, for each data type, which is ASCII encoded, being allocated a line. Standard for the Exchange of Product Model Data (STEP) format describes the data at the product level and not the entity, through a specialized language (Express) that establishes the correspondence between the STEP file and the CAD model. Stereolithography (STL) format is a neutral format based on stereolithography, being used mainly in rapid prototyping devices (laser printing). Parasolid format is a geometric modeling kernel that allows transferring the entire 3D solid model through a single file, while in the case of the other formats, the transfer is done part by part (one file for each part).
The mass and inertia properties of the bodies are automatically calculated by the MBS software (ADAMS, in this case), depending on the 3D solid model imported from CAD and the associated material (defined by the well-known characteristics/properties: Young’s modulus, Poisson’s ratio, and density). Most MBS software solutions (including ADAMS) have their own solid modeling library, the modeling principles being the same as in CAD (elementary solids, composite solids using Boolean operations (union, extraction, and intersection), solids obtained by extrusion and, respectively, rotating surfaces), but for bodies with more complex geometry, the use of specialized CAD environment is required.
Based on the results of the dynamic analysis performed in the MBS environment, the system loads by forces and torques are determined, representing input data for the analysis with finite elements within the FEA software. Subsequently, the deformability state of the components is returned in the MBS software, thus making possible the dynamic analysis of the mechanical system with deformable (flexible) parts, which is more realistic (closer to reality) than the analysis with rigid parts [7, 8]. Through the analysis of compliant models, the stress and vibration states can be determined with the purpose to evaluate the functional and durability performances of the mechanical system. The data transfer from ADAMS to the main FEA environments (such as ANSYS, ABAQUS, or NASTRAN/PATRAN) is done through FEA Loads type format, from the general ADAMS/Exchange transfer interface. The FEA to MBS connection is usually made through the modal neutral file (MNF) format. In ADAMS, the data import from FEA is managed by the ADAMS/Flex interface. It should also be mentioned that ADAMS software package integrates a specialized module, called ADAMS/AutoFlex, which can be used for the conversion of rigid bodies into deformable equivalents, but with certain limitations in the case of more complex geometry bodies, for which it is still necessary to use specialized FEA software.
Finally, regarding the communication between ADAMS and the DFC software environments, in the case of mechatronic systems, the ADAMS package integrates the plug-in ADAMS/Controls through which the data transfer with one of the following DFC software is carried out: MATLAB/Simulink, MATRIXX, and EASY5. Basically, ADAMS/Controls manages the input and output plants of the controlled process (as mentioned above, the outputs from the MBS are inputs into DFC and vice versa respectively), allowing to perform the co-simulation (in-parallel running/processing) of the two main subsystems of a mechatronic system, namely, the mechanical device and the actuating and control device. The information related to the input and output plants are saved in a specific file having the extension .m (for MATLAB) or .inf (for EASY5 and MATRIXX). At the same time, a command file (.cmd) and a data file (.adm) are generated, which are used during the co-simulation process. The files thus generated by ADAMS/Controls are then imported into the DFC application, where the ADAMS interface block is subsequently set and the control block model is designed. It should be mentioned that ADAMS provides some facilities for control system design, which are integrated into the Controls Toolkit module, but obviously not up to the level of complexity offered by dedicated DFC software.
By integrating the mechanical device and the control system at the virtual prototype level, the two models/subsystems are simultaneously tested and verified, thus simplifying the experimental testing process and eliminating (or at least minimizing) the risk that the control law is not accurately tracked (complied) by the mechanical device [9, 10]. Such a mechatronic concept approach is known as concurrent engineering. The simulation algorithm for mechatronic systems involves the following steps:
Within MBS software: modeling the mechanical device (including bodies, joints, actuating elements, other force generating elements), analyzing-simulating the MBS model, modeling the input (I) and output (O) plants in/from the MBS model, and exporting the MBS model for DFC
Within DFC software: importing the mechanical model, synthesizing the desired trajectories of the mechatronic system and modeling the input block diagram (reference signals synthesis), designing the control system block diagram, synthesizing the controller and the electrical interfacing circuits, and simulating the mechatronic system
The so described simulation process creates a closed loop, in which the controlled inputs of the control application affect the simulation in the MBS environment, while the outputs from the MBS simulation affect the level of the controlled signals in DFC.
A complete virtual prototyping process is defined by the following five stages (see also the workflow schematic representation in Figure 2): modeling, analysis, validation, refining, and optimization. During the modeling stage, the specific components of the mechanical or mechatronic system (such as bodies, connections between bodies, actuating elements, and other force generating elements) are created by using the software solutions shown in Figure 1. The output from modeling is the initial virtual model, which is then analyzed (simulated/tested) with the purpose to determine the behavior of the mechanical or mechatronic system, in terms of movement (linear or angular positions, velocities, and accelerations, by case) and reaction force states. The results obtained through the simulation in virtual environment (which are the analysis outputs) are then compared with the corresponding experimental results obtained by physical prototyping, in order to validate the virtual model. It should be mentioned that the physical prototyping is not a stage in itself of virtual prototyping, but a supporting process for this. By the comparative analysis of the virtual and experimental results, one of the following two cases can be reached: valid virtual model (when the virtual results fit with the experimental ones) and invalid virtual model (when the results obtained through the simulation in virtual environment do not match the experimental ones). In the first case, the last step of the virtual prototyping process will be the optimization, which aims to determine the optimal design of mechanical or mechatronic system (in terms of functionality, efficiency-energetic, or economic, by case). On the other hand, if the validation output is expressed by an invalid virtual model, the refining stage must be accomplished with the purpose to improve the fidelity of the virtual model by reference to the physical one. The refined virtual model is then analyzed (by simulation in virtual environment), followed by a new validation. In this way, an iterative process (refining—analysis—validation) is carried out until a valid virtual prototype is obtained, which will be then the subject for optimization.
The virtual prototyping workflow.
The basic principle for a successful virtual prototyping process can be formulated as follows: as complex as necessary and as simple as possible. This is in compliance with Einstein’s statement: “A scientific theory should be as simple as possible, but no simpler.” The idea is to manipulate the simplifying assumptions in a way that reduces the complexity of the virtual model (in order to make the real-time simulation), but without affecting/altering the precision of the results. In other words, a useful virtual prototype should be a trade-off between simplicity and realism. In the following, the implementation of this basic principle regarding the modeling and refining will be discussed for the basic components of a mechanical or mechatronic system, namely, bodies, connections between bodies, and actuating elements. For each of them, the real modeling case and the specific simplifying assumptions (hypotheses) are presented in Table 2.
Components | Real case | Simplifying assumptions |
---|---|---|
Bodies |
|
|
Connections between bodies |
|
|
Actuating elements |
|
|
The modeling of the basic components.
In the real case, all the bodies are flexible (deformable), more or less, depending on the state of loading to which they are subjected, having constant mass (in most cases) and variable inertia properties (by changing the geometric shape). The simplifying assumptions for the modeling of the bodies are obtained from the real case by successively neglecting certain properties, as follows:
Rigid bodies: the shape of the bodies does not change during the analysis, so their inertial properties become constant.
Point masses: the shape is neglected by considering that the whole body mass is concentrated in a point (the center of mass), and in this way the inertia properties are not taken into account.
Bodies without mass (massless bodies): both the mass and the inertia properties are neglected as a consequence of the fact that the bodies are modeled by 2D elements/objects (such as lines, polylines, plane curves).
Composed restrictions: this is a special modeling case in which certain bodies are modeled as constraints between other bodies, such as constant distance or area constraints.
The modeling of the bodies by composed restrictions is not possible for all the bodies in a mechanical or mechatronic system, but only in the following cases:
The body is a mobile one, and not the fixed part of the system (which must remain the reference part to which the global reference frame is attached).
The body is not input (by which movement is introduced into the system) or output part (from which the movement is collected), and this is because the movement can be introduced/collected only through/from bodies.
No external forces or torques are applied to the body, or no force generating elements are connected to the body, and this is because the forces can only act on bodies.
A more detailed discussion on the modeling of the bodies as composed restrictions can be performed in correlation with the MBS models of the four-bar mechanism is schematically represented in Figure 3. So, the model shown in Figure 3a is a general one, with four bodies (three mobile parts, 1, 2, and 3, and the fixed part/ground, 0). Then, in Figure 3b and c, there models shown with three bodies (two mobile parts, 1 and 2 or 3, and the fixed part, 0) and one composed restriction (constant distance between the corresponding ends of the rod 2 and ground, respectively, of the crank 1 and rocker 3). Finally, in Figure 3d, the model is shown with a minimum number of bodies (the rod 2 and the fixed part) and two composed restrictions between the two bodies. The model with a minimum number of bodies is valid one only if the mobile body is at the same time input and output of the system, and this is possible because the body has three movements (two translations along the two axes of the representation plane and one rotation around the axis normal to this plane). The four MBS models shown in Figure 3 are defined by the following numbers of generalized coordinates (movement parameters—6 per each mobile body): 18 (a), 12, (b and c), and 6 (d). Therefore, the model with a minimum number of bodies is the most convenient from the point of view of the complexity, which depends on the number of equations for determining the behavior of the system.
MBS models for the four-bar mechanism: (a) 4-body model, (b, c) 3-body models and (d) 2-body model.
The connections between bodies (excepting the previously discussed composed restrictions, which are not connections with a physical equivalent) are nothing else than contacts between the geometric forms/shapes of the bodies. These contacts can be classified in two groups, with representative examples in Figure 4, as follows:
Stationary (permanent) contacts (Figure 4a), where the connection between bodies is kept as in the initial state during the entire analysis range (throughout the system operation)
Nonstationary contacts (Figure 4b), where the connection between bodies changes during the analysis, either the contact is lost or it occurs or the type of contact changes (e.g., from surface contact to linear or point contact)
Types of contacts (connections) between bodies: (a) stationary and (b) nonstationary.
Given that the real modeling case of the bodies is flexible (deformable) bodies, the real modeling case for the connections between bodies will be contacts between flexible bodies (or briefly, flexible contacts). Then, the first simplifying assumption for the modeling of the bodies (rigid bodies) is automatically transferred to the modeling of the connections, resulting rigid contacts (contacts between rigid bodies). Both in the case of flexible contacts and for rigid contacts, the connections do not restrict movements, but they introduce reaction forces and torques. The other simplifying assumptions for the modeling of the connections are the ones that restrict movements, namely, joints and constraint equations, which can be used only for the stationary connections (such as that shown in Figure 4a, where the contact between the two bodies of the hinge can be modeled as a revolute joint). It should be mentioned that the joint is a symbolical representation (like a modeling shortcut) in the software of the constraint equations, which can be classified in two categories: constraint equations generated by the software (through user-modeled joints), and constraint equations created by the user.
The actuating elements of the mechanical/mechatronic systems are usually found in the following categories (Figure 5): (a) rotary or linear motors/actuators, (b) external factors (such as the wind action for a wind turbine or the road irregularities for a vehicle suspension system), and (c) human operators. Whatever the case, the actuating elements generate mechanical power, which is defined by two components: force and movement. In these terms, the actuating element can be modeled by one of the two mentioned components: motor force/torque and motion restriction. The latter, by which the movement of the actuated (input) bodies is controlled, can be applied at the position, velocity or acceleration (linear or angular, by case) level, usually as in time variation laws. On the other hand, the motion restrictions can be applied in joints (thus controlling the relative motion between the adjacent bodies, as in the case of the jack mechanism shown in Figure 5c, where the relative motion between the crank and the fixed support can be controlled in the revolute joint between the two) or in points (thus controlling the spatial or planar positions of certain points of interest on the body, for example the point located in the end-effector extremity of the industrial robot shown in Figure 5a).
Types of actuating elements of the mechanical/mechatronic systems: (a) motors, (b) external factor and (c) human operator.
As it results from the ones presented in the second section of the paper, the central component of the virtual prototyping platform is the MBS software solution, which is the integrative solution used to simulate and optimize the behavior of the mechanical and mechatronic systems [11, 12, 13, 14, 15]. The analysis flowchart in MBS environment is schematically represented in Figure 6. The types of analysis can be performed separately or coupled in a certain sequence depending on the degree of freedom (DOF) of the mechanism, which expresses the number of uncontrolled (independent) movements, which take place under forces action. The basic components of a mechanical/mechatronic system can be structured in the following way: components that bring movement → mobile bodies; components that eliminate motion → connections between bodies (when they are modeled by joints or constraint equations); components that control motion → actuating elements (when they are modeled by motion restrictions). Thus, the number of degrees of freedom is given by the following equation (Gruebler’s count) [16]:
Analysis flowchart of the mechanical/mechatronic systems.
where n is the number of mobile bodies, Σr is the sum of geometric restrictions (joints and/or composed restrictions), and Σrm is the sum of motion restrictions.
To better understand the above, Figure 7 shows three modeling cases for an open-loop system formed by two bodies (the mobile part and the ground) connected by a revolute joint, with the following particularities: (a) there is no actuating element; (b) the actuating element is modeled by a motion restriction, controlling in this way the angular position of the rotating body/crank; and (c) the actuating element is modeled by a motor torque applied on the rotating body. For the three cases, the following numbers of degrees of freedom are corresponding: (a) DOF = 6–5 = 1; (b) DOF = 6 − (5 + 1) = 0; (c) DOF = 6 − 5 = 1. Therefore, the second model (b) has no independent motion, the angular positions of the crank being controlled (imposed) by the motion restriction regardless of the mass and the inertial properties of the body. In the first (a) and the third (c) case, respectively, the model has one uncontrolled motion (the rotation of the crank), which is influenced by the action of the forces (mass and inertia forces in the both cases, and in addition the motor torque in the third case). Thus, the motion restrictions remove degrees of freedom, by controlling the motion, while the motor forces/torques do not remove degrees of freedom.
(b) Controlled vs. (a, c) uncontrolled movement.
The four types of analysis shown in Figure 6 are defined by the following:
Dynamics: inputs, the assembled configuration (bodies and connections), and the loads through forces and/or torques (all of them) outputs, the time histories of motion and reaction states
Kinematics: inputs, the assembled configuration and motion restrictions (no forces/torques), and outputs, the time histories of motion
Statics: inputs, the assembled configuration and the loads through forces and/or torques (excepting the forces that depend on velocity and acceleration, such as damping and inertia forces), and output, the equilibrium configuration
Inverse dynamics: inputs, the same as in dynamics, but with the actuating elements as in kinematics, and outputs, the motor forces/torques
Considering the particularities of the simplifying assumptions for the modeling or refining of the basic components of the mechanical/mechatronic systems (as presented in the 3rd section of the paper) and those of the types of analysis mentioned above, Table 3 shows the correlations between the simplifying assumptions and the analyses, which can be interpreted as validity fields for hypotheses (i.e., analyzss where the use of hypotheses does not generate errors).
Components | Simplifying assumption | Analysis |
---|---|---|
Bodies | Rigid bodies | Dynamics |
Inverse dynamics | ||
Point masses | Statics | |
Massless bodies | Kinematics | |
Composed restrictions | ||
Connections between bodies | Rigid contacts | Dynamics |
Inverse dynamics | ||
Joints/constraint equations | Kinematics | |
Statics | ||
Dynamics | ||
Inverse dynamics | ||
Actuating elements | Motion restrictions | Kinematics |
Inverse dynamics | ||
Motor forces/torques | Dynamics | |
Statics |
The validity fields of the simplifying assumptions.
The analysis methodology of the mechanical/mechatronic systems by using MBS software environment (ADAMS in this case) involves three stages: pre-processing (system modeling), processing (model running), and post-processing (processing results). The pre-processing stage involves indicating the input data, as follows: specifying information regarding the calculations to be performed, such as the type of analysis to be carried out, the units of measurement, the type of coordinate system (e.g., Cartesian), the gravitational acceleration vector, and the analysis time interval and modeling the components of the mechanical/mechatronic system (bodies, connections between bodies, actuating elements, and other force generating elements, such as springs or dampers, by case). The processing stage is performed automatically by the program, and consists from generating and solving the algebraic and differential equations that mathematically describe the system. The post-processing stage consists of processing the analysis results, by drawing variation diagrams/charts, generating tables with numerical values, and creating graphical animations, all of which providing an overview of how the mechanical/mechatronic system behaves.
Based on the above, a case study corresponding to a high complexity system, namely, a suspension system for motor vehicles, is presented below. The virtual model contains the front and rear wheel suspension subsystems, as well as the actuating subsystem. The prototype is used for simulating the passing over bumps dynamic regime under laboratory conditions, through the use of a virtual testing bench (Figure 8). The approach is a mechatronic one, in the sense that the actuating subsystem, containing four linear actuators that sustain/support and move the wheels, is controlled in such a way as to ensure the desired running path profile by the vertical displacements that apply to the wheels. The virtual model of the mechanical device (including the two suspension subsystems, the car body, and the testing bench) was developed by using the MBS software environment ADAMS. The 3D solid model was developed with the help of the CAD software environment CATIA, the transfer to ADAMS being performed as described in the second section of the chapter.
The MBS virtual model of the vehicle.
The front wheels suspension subsystem (Figure 9) contains two independent Short-Long Arm (SLA) mechanisms, also called double-wishbone. The lower (long) and upper (short) arms of the mechanism are double-hinged to the car body by using bushings (compliant joints), while the other ends (outward) of the arms are connected to the wheel carriers by spherical joints. The same type of joints was used for the connections of the steering rods to the adjacent parts (wheel carriers and car body). The rear wheels suspension subsystem (Figure 10) ensures the guiding of the whole axle in the relative movement to the car body by a so-called 4S suspension mechanism, with four longitudinal arms that are connected to the adjacent bodies by bushings. In the case of the front suspension, the spring and damper groups are mounted between upper arms and car body, while for the rear suspension, these elastic and damping elements are arranged between axle and car body. For the both suspension systems, the bumpers limiting the run (extension, and respectively compression), which are nonstationary elastic elements, are disposed inside the dampers, thus limiting the relative displacement between the two parts of the damper (cylinder and piston).
The front wheels suspension subsystem.
The rear wheels (axle) suspension subsystem.
The connections between the wheels and the upper platters of the actuators were modeled by contact forces between the corresponding geometries, which allow considering the stiffness and damping properties of the tires, as well as the friction between the bodies. As mentioned, the vertical displacement of the actuator plates is controlled so as to simulate the passing of the vehicle over various types of obstacles (road irregularities), the movement being transmitted to the wheels and then, through the suspension mechanisms, to the car body. The control system for the actuating elements (Figure 11) was designed with the help of the DFC software solution engineering analysis systems (EASY5). In this model, the MBS mechanical device is referred by the ADAMS Mechanism block. It should be mentioned that ADAMS and EASY5 software solutions are produced—marketed by MSC Software Corp., so the compatibility between them (in terms of facilities for data transfer for the purpose of co-simulation) is very good.
The DFC model of the control system.
The modeling of the actuation and control system was carried out in mechatronic concept, by integrating the mechanical model (Figures 8–10) and the control system model (Figure 11) at the virtual prototype level. Thus, the two models (MBS and DFC) are being tested—verified simultaneously, minimizing the risk that the control law not to be followed by the mechanical model. In this case, the mechanical and control models are connected and communicate one with other through the use of ADAMS/Controls. The communication scheme between the MBS model and the control system is shown in Figure 12. The inputs into the mechanical model (outputs from the control system) are the motor forces developed by the four linear actuators, while the outputs from ADAMS (inputs into EASY5) are the vertical positions of the wheel actuator plates.
The input and output plants.
The input and output plants were defined by using a set of ADAMS state variables. The input state variables (the motor forces) are defined in ADAMS by null values, going to receive their values from the control application. The input variable is called by using the predefined function VARVAL (variable), which returns the value of the variable. For the output state variables, the time functions return the linear displacements along the vertical axis (Y). The output variables are modeled by using the predefined function DY (To Marker, From Marker), where the markers represent coordinate systems belonging to the adjacent parts (actuator cylinder and piston respectively), placed in the translational joint between the two parts of the actuator. The input variables are reported by plant input, PIN1–4, and the output variables by plant output, POU1–4. Information related to the input and output plants are saved in a specific file for EASY5 (*.inf); at the same time, a command file (*.cmd) and a data file (*.adm) are generated for the subsequent co-simulation. In the ADAMS Mechanism interface block, the execution mode is then defined; in this case co-simulation, specifying also the interval with which ADAMS/Controls, writes the results to files and adapts the animation and the communication range between ADAMS and EASY5 [17].
As mentioned, the vertical positions of the wheel actuator plates are imposed to simulate the passing of the wheels over bumps (road irregularities). For the study presented in this work, it was considered the road profile shown in Figure 13, which includes four speed bumps with a height of 20 mm. The delays between the excitations of the wheels (front-rear and left-right, respectively) correspond to a vehicle speed of 20 km/h (the vehicle has the wheelbase, i.e., the distance between the front and rear axles, of 2.4 m). In the DFC (control system) model shown in Figure 11, the imposed movement laws were defined by using the step function generator blocks SF1–SF4. This type of input data block is defined by the time at initiation of step input (To_SF) and the step input value (STP_SF). The step is triggered when time equals T0_SF and steps to a value of STP_SF, in accordance with the following conditional function:
The road profile simulated by the virtual test bench.
where S_Out_SF is the step signal output, which is compared (by using a summing junction block) with the current position provided by the MBS model.
For each of the four linear actuators, PID controller was used as a control element. This controller corrects the difference between the imposed (desired) and current (measured) values of a specific parameter by computing and applying a compensatory measure that adapts the system properly [18, 19]. The optimal design of the controller can be achieved both by methods specific to the control theory (e.g., root locus, frequency methods), as well as by optimal parametric design techniques [20, 21, 22]. For this work, the optimization was performed by using the scripting capabilities integrated in EASY5 Matrix Algebra Tool (MAT), the control system model being managed as an EMX function. The optimization procedure is similar with that presented in [23]. The optimization goal is to minimize the difference between the imposed and current values of the actuator plate vertical position, while the design variables are the proportional (P), integral, (I) and derivative (D) factors of the controller.
In the conditions specified above, the time history variations of the vertical positions of the front and rear actuator plates are shown in Figure 14. The mechanical powers developed by the four linear actuators for generating the predefined movement laws, which were determined by multiplying the motor forces by the linear velocities of the actuator plates, are the ones shown in Figure 15. Some results that describe the dynamic behavior of the vehicle are presented in Figure 16, namely, the vertical displacement of the car body (a), which is measured in its center of mass and the roll and pitch oscillations/angles (b).
The vertical displacements of the front (a) and rear (b) actuator plates.
The power developed by the front (a) and rear (b) linear actuators.
The main linear (a) and angular (b) oscillations of the car body.
Further, the guiding arms of the front and rear suspension mechanisms, which were initially modeled as rigid bodies, were discretized into finite elements, for studying their deformability and stress state. The conversion from solid to flexible was achieved by using ADAMS/AutoFlex. For example, Figure 17 shows the conversion window for the rear upper right arm, while in Figure 18 the finite element model of this body, along with its first three vibration modes. It should be mentioned that ADAMS/AutoFlex allows viewing 18 vibration modes per flexible body, each mode of vibration being characterized by a modal frequency and a mode shape [24]. A dynamic simulation graphical frame for the compliant model (with flexible bodies), focused on the rear axle guiding mechanism, is shown in Figure 19, revealing the stress state of the guiding arms.
Example of conversion from solid body to flexible body.
The FEA model of the rear upper right arm.
Dynamic simulation graphical frame.
Many other results can be extracted from the simulations in virtual environment, for all the objects—components of the virtual model (e.g., bodies, connections between bodies, actuating elements, elastic and damping elements) and for any type of parameter (e.g., motion, force, energy), including results that cannot be measured experimentally for various reasons (such as lack of adequate sensors, hard to reach areas, high temperatures in the measuring area, and others). At the same time, by studying the influence of the various parameters that define the model (such as the global coordinates of the joint locations or the elastic and damping coefficients of the spring and damper assemblies) on the vehicle behavior, its kinematic and dynamic optimization can be simplified, by selecting the parameters which significantly influences the comfort, stability, or maneuverability of the vehicle.
The use of virtual prototyping software platforms in the analysis and optimization of the mechanical and mechatronic systems offers important benefits, which focus on reducing the costs, as well as the design and development time while increasing the quality (operational performances of the products). The virtual prototypes are not made from real materials (such as steel, aluminum or wood) that are generally expensive, but from bits, with which any type of material can be simulated. Other significant cost reductions result from the fact that virtual prototyping does not involve destroying prototypes during testing (e.g., in the real car crash tests), the virtual prototype being restored to its original state by a simple mouse click. Multiple design variations (in various parameter combinations) can be explored early, without going through expensive (and often superficial) physical prototyping cycles. The virtual prototyping technique allows the replication on computer of both the product itself and the specific operating (working) environment. Among the critical success factors regarding the successful implementation of the virtual prototyping platforms, we can point to well-defined process, system-level orientation, efficient setting of the goal, rapid dynamics of the simulation, and high-quality infrastructure (hardware and software).
High ambient temperature (HTa) is the natural environmental condition in the tropical area. Dairy animals fed in tropical countries are living under prolonged HTa conditions. A decrease in the lactation performance in dairy animals is one of the well-known effects of HTa [1, 2, 3, 4]. In dairy cows, we have shown that the average daily milk yield (MY) from summer cows was 17% lower than from winter cows [4, 5]. The effect of HTa on MY was also consistent in dairy goats [6]. Although, a decrease in MY is the prominent negative effect of HTa, however, change in major milk composition from dairy animals during HTa exposure is not conclusive. The current chapter aims at showing the evidence that HTa has the potential to change milk protein in dairy goats fed under tropical areas. We first demonstrate the natural ambient condition. The effect of HTa on lactation performance and the mechanism has been informed. In addition to MY, the evidence of HTa effect on milk protein and the putative molecular mechanism of this phenomenon has also been proposed.
The tropical countries are the area that delimited between the tropic of Cancer in the north (23.43° S) and the tropic of Capricon in the south (23.43° S). Based on the seasonality of monthly air temperature and precipitation, the climatic classification of the mainland Southeast Asia countries including Thailand, Laos, Myanmar, Cambodia and Vietnam are mainly the tropical savannah (Aw). In addition, the climatic classification of the maritime Southeast Asia countries including Malaysia, Indonesia, Brunei and Philippine is the tropical monsoon (Am). Due to the global warming effect, the temperature and humidity index (THI) which has been reported currently is approximately 10 degrees higher than that has been reported 30 years ago [7]. The current annual THI in the central of Thailand was approximately 85 [4]. The high value of THI in Thailand currently comes mainly from the high degree of ambient temperature (Ta) throughout the three main seasons. Interestingly, the difference in Ta between the highest level during the afternoon and the lowest level during the early morning is more than 10°C (Figure 1). This Ta difference (Ta-diff) is mainly the environmental condition influencing the lactation performance and perhaps the direct effect of temperature on mammary gland function [6].
The pattern of ambient temperature in the central area of Thailand represent the typical climatic condition of the tropical area at the present time.
The effect of HTa on whole-body responses and MY should be considered before discussing the HTa effect on milk protein synthesis. Dairy cows and goats fed under HTa conditions in the tropical area have 15–17% lower MY during summer than during winter [4, 5, 6, 8]. Both direct and indirect effect of HTa on lactation performance has been purposed.
The direct effect of HTa on mammary gland function has been demonstrated using both
The ratio of β-GALT1 and Hsp70 gene expression from both
The indirect effect of HTa on MY mediates by the effect of HTa on decreased food intake (FI) and nutrient partition to the mammary gland [6, 12, 13, 14]. Dairy goats in the summer months had significantly lower FI and MY than that in winter months. Because the concentration of plasma cortisol from summer months was not different from winter months [6], whether these effects of HTa are part of the chronic heat stress mechanism is not conclusive. When considering the effect of HTa on FI in laboratory rats, the low degree of HTa exposure that decreased FI earlier than the activated hypothalamic-pituitary axis implies that HTa could decrease FI without stress [15, 16]. The information of behavioral and physiological responses to daily fluctuation of HTa is crucial knowledge regarding this phenomenon.
Behavioral and physiological responses of HTa during daytime is a piece of crucial information to support the hypothesis that dairy goats and cows fed under natural ambient conditions are at the stage of heat stress. Early phase responses of HTa are all behavioral outcomes without the activation of the hypothalamic-pituitary axis (HPA axis) including seeking shade, inactivity and decrease in food intake, etc. Mild degree heat stress is the second phase is characterized by the physiological responses and the activation of HPA axis. This level of heat stress is reversible and not harmful. Heat dissipation mechanism including sweating or panting is the major physiological response during this phase. The third phase of heat stress is a severe irrevisible level or heat stroke. We have shown previously that there is around a 10°C difference in Ta from early morning to the afternoon (Figure 1). The significant increases in both respiratory rate (RR) and rectal temperature (Tr) could be detected in dairy goats fed under this ambient condition (Figure 3). Similar patterns of these responses have been demonstrated in dairy cow fed under natural HTa conditions [17]. Moreover, the plasma concentration of cortisol from the afternoon was significantly higher than that from the early morning (Figure 4). This information suggests that in dairy goats when the difference of Ta during morning and afternoon is around 10°C, both evaporative heat dissipation and the HPA axis were activated. Although the dairy goat had significant heat dissipation via panting, the core temperature (via Tr) was set to around 1°C above normal level in the morning. It should be noted at this point that the behavioral and physiological responses of HTa in dairy goats are comparable to those we have investigated in the laboratory rat. Short-term mild degree of HTa exposure in rats that could not activate physiological responses (e.g., Tr and pack cell volume) failed to activate the paraventricular nucleus (PVN) of the hypothalamus [15]. It is well known that PVN is the most upper hypothalamic nuclei of the stress axis (or HPA axis). Taken together, we conclude that during daytime dairy goat fed under HTa of the tropical area is at the second phase of heat stress.
The effect of high ambient temperature (HTa) on behavioral and physiological response in dairy goats during daytime from 0700 h to 1300 h. In the morning (0700 h), the respiratory rate (RR, upper) as behavioral response and the rectal temperature (Tr, lower) as the physiological response is at normal value. In the afternoon (1300 h), both RR and Tr increase significantly to 127 breaths per min and 39.64°C, respectively.
The effect of high ambient temperature (HTa) on hormonal response in dairy goat during daytime from 0700 h to 1300 h of summer and winter period. * the significant effect of time.
Although the THI from winter was lower than that from summer in Thailand, both winter and summer THIs during the afternoon were higher than the value of 80 [4, 6]. It is possible to think that in Thailand dairy goat from both winter and summer times is at the state of heat stress and that the concentration of plasma cortisol per se could not be used as the separation index at this stress level. Finally, from the meteorological and behavioral viewpoints, dairy goat during summer period confronted with higher degree of heat stress than during winter period.
During the summer period, both dairy cows and goats decreased in lactation performance. An evidence that dairy goat fed under the tropical area of Thailand during the summer period has a higher degree of heat stress than the winter period drives one interesting hypothesis. This hypothesis is whether the major compositions of milk from the summer period is different from that of the winter period. The analysis of major goat milk compositions revealed that the concentration of milk protein, but not milk lactose and fat, from the summer period was higher than that of the winter period (Figure 5). It should be noted that the present effect of HTa on milk protein is in contrast with previous reports [18, 19, 20]. The possible explanation for this discrepancy is perhaps the degree and duration of HTa exposure that is typical high throughout the year in the current condition of tropical area. Furthermore, the effect of HTa on milk protein synthesis seems to be specific because HTa did not affect the concentration of lactose both
The effect of high ambient temperature (HTa) on goat milk composition between winter and summer period. * the significant effect of season.
Because casein is the major milk protein, this section will focus on the effect of HTa and the casein synthetic pathway that may be the major cause of this phenomenon. With an evidence that HTa could activate Hsp70 expression from our current experiment [9], increase casein synthesis may be supported by the action of Hsp70 (Figure 6). Among a wide range of Hsp70 functions and subtypes [22, 23], Hsp70-5 or glucose-regulated protein 78 (GRP78) which locate at the endoplasmic reticulum (ER) and regulate ER chaperone and transportation has been studied with milk protein synthesis. Overexpression of GRP78 in bovine mammary epithelial cells increased milk protein synthesis [24]. In addition, the role of the Mammalian target of rapamycin (mTOR) as the posttranscriptional regulation has been revealed regarding to milk protein synthesis [25]. Interestingly, mTOR has been shown in HeLa cells that could stimulate Hsp70 synthesis via heat shock transcription factor 1 (HSF1) [26]. The effect of HTa that increase milk protein may be related to the mTOR/HSF1/Hsp70 pathway that regulate the posttranslational process of casein. The casein subtype is another regulatory mechanism controlling the posttranslational casein synthesis pathway. Basically, casein is the milk protein complex known as casein micelle that is composed of 4 major subtypes; αS1-casein, αS2-casien, β-casein and κ-casein. Before the casein incorporation process that takes place at the Golgi apparatus, it is important that all casein subtype need to synthesize and transported from ER to the Golgi apparatus via the ER-Golgi transport route. It has been demonstrated in αS1-casein deficient goat that αS1-casein is required for the efficient transport of β-casein and κ-casein [27]. Furthermore, the membrane-associated form of αS1-casein at ER plays a key role during the early steps of casein transport. Whenever αS1-casein has been down-regulation, the transport rate of other caseins to Golgi apparatus is highly decreased [28]. Taken together, it is interesting at this point that HTa could activate mTOR/HSF1/Hsp70 pathway and subsequently influence ER-Golgi transport of the casein subtype.
The diagram demonstrates a putative mechanism that high ambient temperature (HTa) increases casein synthesis. Under prolonged HTa conditions, heat shock protein 70 (Hsp70) is increased. The upstream pathway that activates Hsp70 may be related to the mammalian target of rapamycin (mTOR). An increase in Hsp70 chaperone of ER-Golgi transport of casein subtype is the putative target that enhances casein production. The transportation of casein by the ER-Golgi route requires coat protein complex (COP) machinery; COPII and COPI proteins which initiate at the ER exit site (ERES). The vesicular tubular cluster (VTC) is the final step that casein will be transported to Golgi.
In this chapter, we demonstrate that dairy goat and cow fed under tropical area were at the state of heat stress. In addition to the effect of HTa on the reduction in MY, we show the evidence that long-term HTa exposure apparently increased milk protein. The physiological mechanism that HTa could influence milk protein synthesis has been proposed in particular with the casein synthesis pathway. Specifically, long-term HTa exposure activates mTOR/HSF1/Hsp70 pathway and subsequently increases the posttranslation process of casein synthesis via ER-Golgi casein transportation.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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