Comparison between molecular chemistry and materials chemistry context for different concepts.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5313",leadTitle:null,fullTitle:"Update on Dementia",title:"Update on Dementia",subtitle:null,reviewType:"peer-reviewed",abstract:"The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.",isbn:"978-953-51-2655-3",printIsbn:"978-953-51-2654-6",pdfIsbn:"978-953-51-4178-5",doi:"10.5772/61983",price:159,priceEur:175,priceUsd:205,slug:"update-on-dementia",numberOfPages:558,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"6b264ef130a59fe71274c3811750e6c3",bookSignature:"Davide Vito Moretti",publishedDate:"September 28th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5313.jpg",numberOfDownloads:46161,numberOfWosCitations:63,numberOfCrossrefCitations:44,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:92,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:199,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 19th 2015",dateEndSecondStepPublish:"December 10th 2015",dateEndThirdStepPublish:"March 29th 2016",dateEndFourthStepPublish:"June 27th 2016",dateEndFifthStepPublish:"July 27th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"147154",title:"Dr.",name:"Davide",middleName:"Vito",surname:"Moretti",slug:"davide-moretti",fullName:"Davide Moretti",profilePictureURL:"https://mts.intechopen.com/storage/users/147154/images/4806_n.jpg",biography:"Dr. Davide Vito Moretti is a consultant neurologist and senior researcher at the National Institute of Research and Cure for Mental Disorders and Dementia, St. John of God Institute, Brescia, Italy. Since 2014, he is a professor of Neurophysiology at the UniLudes University in Lugano. He received his medical degree from the Catholic University in Rome and completed his residency in neurology and fellowship in movement disorders at the State University in Trieste. Moreover, he received his PhD in Neurophysiology at the Sapienza University of Rome.\nDr. Moretti is currently involved in research and care of subjects with Alzheimer’s disease and dementia in the Memory Clinic/Alzheimer Operative Unit of the St. John of God Institute. Moreover, he is the chief of the clinical neurophysiology unit and of the Alzheimer’s disease rehabilitation operative unit. Since March 2015, he is also the head of the whole rehabilitation in dementia line research in the St. John of God Institute.\nHis research is primarily concerned about Alzheimer’s disease both in prodromic and in clinically evident phase of the disease, Parkinson’s disease, movement disorders, and clinical neurophysiology.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Centro San Giovanni di Dio Fatebenefratelli",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1171",title:"Developmental Cognitive Neuroscience",slug:"developmental-cognitive-neuroscience"}],chapters:[{id:"52167",title:"Alternative Splicing and Alzheimer’s Disease",doi:"10.5772/64513",slug:"alternative-splicing-and-alzheimer-s-disease",totalDownloads:1850,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Alzheimer’s disease is a neurodegenerative process whose origin is unknown. It has been associated with this process at least two important proteins: the first is the β-amyloid forming amyloid plaques and the second protein is Tau, which has been determined to precipitates inside the neuron because hyperphosphorylation, causing instability in the axon. Tau microtubule-associated protein (MAP) is essential for the development of neuronal cell polarity. Tau protein is preferentially localized in the axons, whereas MAP2, another neuronal specific microtubule-associated protein, is localized in the somatodendritic domain. Previous studies have demonstrated that the localization of these proteins depends, at least in part, on messenger RNA (mRNA) subcellular localization, that is, Tau mRNA into the axon and MAP2 mRNA into the dendrite. Tau protein has an essential role in the pathology of Alzheimer’s disease, and hyperphosphorylated Tau promotes destabilization of microtubules. Tau alternative splicing generates six isoforms in the adult human brain due to the inclusion or exclusion of exons 2, 3, and 10. The failure in the splicing process of exon 10 generates a tauopathy, which can be carried out by the amyloid peptide; however, the splicing of other exons is less studied. The impact of amyloid peptide on the alternative splicing of exons 2, 3, and 6 caused formed cell processes to retract in differentiated cells and altered the expression of exons 2/3 in cell culture. Expression of exon 6 was repressed under β-amyloid treatment. The molecular mechanism for this amyloid-Tau interaction remains to be determined, but may have potential implications for the understanding of the underlying neuropathological processes in Alzheimer’s disease.",signatures:"Gonzalo Emiliano Aranda Abreu, Sonia Lilia Mestizo Gutiérrez,\nMaría Elena Hernández Aguilar and Fausto Rojas Durán",downloadPdfUrl:"/chapter/pdf-download/52167",previewPdfUrl:"/chapter/pdf-preview/52167",authors:[{id:"72314",title:"Dr.",name:"Gonzalo Emiliano",surname:"Aranda Abreu",slug:"gonzalo-emiliano-aranda-abreu",fullName:"Gonzalo Emiliano Aranda Abreu"},{id:"186065",title:"Dr.",name:"Sonia Lilia",surname:"Mestizo Gutiérrez",slug:"sonia-lilia-mestizo-gutierrez",fullName:"Sonia Lilia Mestizo Gutiérrez"},{id:"186066",title:"Dr.",name:"María Elena",surname:"Hernández Aguilar",slug:"maria-elena-hernandez-aguilar",fullName:"María Elena Hernández Aguilar"},{id:"186067",title:"Dr.",name:"Fausto",surname:"Rojas Durán",slug:"fausto-rojas-duran",fullName:"Fausto Rojas Durán"}],corrections:null},{id:"51676",title:"Neuroinflammation and Neurodegeneration",doi:"10.5772/64545",slug:"neuroinflammation-and-neurodegeneration",totalDownloads:3435,totalCrossrefCites:6,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Pathophysiological processes of neurodegenerative diseases are not clearly defined. However, an important body of evidence points toward the role of various inflammatory processes. The microglial cell is the main representative of the immune system in the central nervous system (CNS). This cell type can sense foreign or harmful pathogens and trigger its own activation and the generation of neuroinflammatory processes through phagocytosis and the release of cytokines, in order to maintain the cellular microenvironment. However, after maintaining a permanent state of activation due to sustained stimulation over time, microglial cells may generate a focus of persistent inflammation that in some cases precedes or enhances the neurodegenerative process. Thus, neuroinflammatory microenvironment becomes toxic and harmful for the neuronal cell, which degenerates and releases various factors that in turn activate the inflammatory response of microglia, potentiating the neurodegenerative cycle. In this chapter, we discuss the evidence on the role of microglial cell activation in neurodegenerative conditions and the association between neuroinflammatory processes and age-related neurological diseases. Finally, we outline how this new approach can help us to find new ways to understand neurodegenerative processes and to orientate the search for new therapies.",signatures:"Inelia Morales, Gonzalo A. Farías, Nicole Cortes and Ricardo B.\nMaccioni",downloadPdfUrl:"/chapter/pdf-download/51676",previewPdfUrl:"/chapter/pdf-preview/51676",authors:[{id:"137002",title:"Dr.",name:"Gonzalo",surname:"Farias",slug:"gonzalo-farias",fullName:"Gonzalo Farias"},{id:"183194",title:"Dr.",name:"Ricardo",surname:"Maccioni",slug:"ricardo-maccioni",fullName:"Ricardo Maccioni"},{id:"183196",title:"MSc.",name:"Inelia",surname:"Morales",slug:"inelia-morales",fullName:"Inelia Morales"},{id:"183197",title:"MSc.",name:"Nicole",surname:"Cortes",slug:"nicole-cortes",fullName:"Nicole Cortes"}],corrections:null},{id:"51651",title:"High-Fat and Cholesterol Intake Affects Brain Homeostasis and Could Accelerate the Development of Dementia: A Systemic View",doi:"10.5772/64357",slug:"high-fat-and-cholesterol-intake-affects-brain-homeostasis-and-could-accelerate-the-development-of-de",totalDownloads:1865,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:'Alzheimer’s disease is the most common type of dementia in occidental countries. The majority of the cases develop the disease for no genetic reasons; therefore, it is crucial to establish which environmental factors trigger the development of the disease. It has been proposed that nutritional habits, especially main components of Western countries’ diet such as saturated fat or cholesterol, increase the risk for development of Alzheimer’s disease (AD) and/or accelerate the onset of the disease, which is a big concern in countries where obesity is a public health problem. It is crucial to understand the links between alimentary habits and the development of AD and other types of dementia. A possible mechanism is the disruption of blood–brain barrier (BBB), which is the protection of the brain from circulating blood. Such disruptions can result from consuming high-fat diet (HFD) or high-cholesterol diet (HCD) and inflammation produced by alteration in brain vasculature resulted for chronic consumption of such type of diets. What has named a "Systemic view" comprises the idea that; what happens outside of the brain environment does affect brain functioning and the modifications experienced in the brain environment resulted from the influence of external factors will affect the entire body. In the current chapter, we will review the state of the art in the studies of the impact of a diet rich in fat or cholesterol on the brain and how the alterations induced in other organs can impact brain functioning increasing the susceptibility of development of dementia.',signatures:"Marco Antonio Meraz-Ríos and Perla Leal-Galicia",downloadPdfUrl:"/chapter/pdf-download/51651",previewPdfUrl:"/chapter/pdf-preview/51651",authors:[{id:"114746",title:"Dr.",name:"Marco",surname:"Meraz-Ríos",slug:"marco-meraz-rios",fullName:"Marco Meraz-Ríos"},{id:"187600",title:"Dr.",name:"Perla",surname:"Leal-Galicia",slug:"perla-leal-galicia",fullName:"Perla Leal-Galicia"}],corrections:null},{id:"51637",title:"Plasma Biomarkers in Alzheimer’s Disease",doi:"10.5772/64512",slug:"plasma-biomarkers-in-alzheimer-s-disease",totalDownloads:1887,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Biomarker study on dementia has developed widely. In applying biomarkers, there seems to be several utilizations such as presymptomatic- and early-stage detection, differential diagnosis, and evaluation of treatment effect. Currently, most reliable fluid markers are amyloid peptide (Aβ) with microtubule-associated protein tau (TAU) and phosphorylated TAU (P-TAU) detected in cerebrospinal fluid (CSF). Aβ42 correlates with plaque pathology, TAU reflects the intensity of neuroaxonal degeneration, and P-TAU may correlate with neurofibrillary tangle (NFT) pathology. An attenuation of the level of Aβ42 and elevation in the ratio of Aβ42 relative to the shorter major species of Aβ42 peptide with 40 amino acid residues (Aβ40) has been identified as significant events in the early stage of Alzheimer’s disease (AD) pathology. In addition, there is great interest in blood-based markers of AD since blood extraction is much less invasive. Moreover, plasma biomarkers can be measured at relatively low expense once a standard system of measurement is established. Although there is not yet an established or validated diagnostic test for plasma biomarkers, there is great interest in blood-based markers. We will summarize reported biomarkers, describe our novel potential plasma biomarker for AD (annexin A5), offering a strategy for selecting candidates, and show our results and evaluation.",signatures:"Hitoshi Sohma and Yasuo Kokai",downloadPdfUrl:"/chapter/pdf-download/51637",previewPdfUrl:"/chapter/pdf-preview/51637",authors:[{id:"179340",title:"Prof.",name:"Hitoshi",surname:"Sohma",slug:"hitoshi-sohma",fullName:"Hitoshi Sohma"},{id:"180263",title:"Prof.",name:"Yasuo",surname:"Kokai",slug:"yasuo-kokai",fullName:"Yasuo Kokai"}],corrections:null},{id:"51964",title:"Alzheimer’s-Related Amyloid Beta Peptide Aggregates in the Ageing Retina: Implications for Sight Loss and Dementia",doi:"10.5772/64790",slug:"alzheimer-s-related-amyloid-beta-peptide-aggregates-in-the-ageing-retina-implications-for-sight-loss",totalDownloads:1850,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Although visual problems are reported by patients with Alzheimer’s disease and dementia, studies into this particular aspect of neuropathology are scarce. The growing awareness of complex pathological processes in the ageing retina and brain, however, enables us to consider this from a new perspective. Here we discuss the latest findings on the wide-ranging visual defects experienced by those suffering from Alzheimer’s disease and dementia. We propose that events leading to chronic degeneration of the retina and the brain in fact share many striking similarities. In particular, we discuss the role of the Alzheimer’s-related amyloid beta (Aβ) group of peptides that has been shown to accumulate in senescent retinas, correlated with increased risk of retinal degeneration. The high photo-oxidative retinal environment creates ideal conditions for Aβ aggregation, evidenced by high Aβ loads reported in aged and donor eyes from patients with age-related macular degeneration. Consequently, longitudinal and non-invasive retinal assessments may provide invaluable information on incipient pathology and disease progression in the retina as well as the senescent brain. Such insights may not only lead to identifying new pathogenic mechanisms in the retina with implications for understanding Alzheimer’s disease but reveal the underlying causes of visual abnormalities reported in patients with dementia.",signatures:"J. Arjuna Ratnayaka and Savannah Lynn",downloadPdfUrl:"/chapter/pdf-download/51964",previewPdfUrl:"/chapter/pdf-preview/51964",authors:[{id:"183572",title:"Dr.",name:"J Arjuna",surname:"Ratnayaka",slug:"j-arjuna-ratnayaka",fullName:"J Arjuna Ratnayaka"},{id:"183847",title:"Ms.",name:"Savannah A.",surname:"Lynn",slug:"savannah-a.-lynn",fullName:"Savannah A. Lynn"}],corrections:null},{id:"51804",title:"Proteomic Study of Degenerative Protein Modifications in the Molecular Pathology of Neurodegeneration and Dementia",doi:"10.5772/64693",slug:"proteomic-study-of-degenerative-protein-modifications-in-the-molecular-pathology-of-neurodegeneratio",totalDownloads:1619,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Dementia is a major public health burden, and the World Health Organization has identified this disorder as a major public health priority. There are limited treatment options due to poor understanding of key mechanism of dementia pathogenesis. Dementia has been regarded as a proteinopathy in which alterations of brain protein structure and function are the key features of the disorder. Proteinopathy can be triggered by degenerative protein modifications (DPMs), misfolding, aggregation, and deposition of the malformed proteins. Despite the clinical significance of alteration in protein abundances, DPMs, protein misfolding, and aggregation, the molecular mechanism that promotes these changes remains inadequately understood, mostly due to technical challenges. Proteomic is a powerful, sensitive, and advanced tool to study the progressive brain tissue damage that critically dysregulates key enzymes, accumulates modified proteins, and causes protein misfolding and aggregation, resulting in cognitive decline and dementia. The proteomic profiling of protein abundances and correlating DPMs with protein misfolding and aggregation have potential to elucidate underlying molecular mechanism of the disease. This chapter summarizes the recent proteomic developments for studying brain proteome, DPMs, and protein aggregation mechanism that may lead to dementia. We attempted to correlate DPMs and its impact on protein aggregation and deposition in brain tissues.",signatures:"Sunil S. Adav and Siu Kwan Sze",downloadPdfUrl:"/chapter/pdf-download/51804",previewPdfUrl:"/chapter/pdf-preview/51804",authors:[{id:"184065",title:"Dr.",name:"Siu Kwan",surname:"Sze",slug:"siu-kwan-sze",fullName:"Siu Kwan Sze"},{id:"187076",title:"Dr.",name:"Sunil S",surname:"Adav",slug:"sunil-s-adav",fullName:"Sunil S Adav"}],corrections:null},{id:"52003",title:"Brain Lipids in the Pathophysiology and Treatment of Alzheimer’s Disease",doi:"10.5772/64757",slug:"brain-lipids-in-the-pathophysiology-and-treatment-of-alzheimer-s-disease",totalDownloads:2116,totalCrossrefCites:2,totalDimensionsCites:13,hasAltmetrics:1,abstract:"Alzheimer’s disease (AD) is a neurodegenerative disorder that causes severe and progressive cognitive impairment. The discovery of specific mutations related to AD supported the amyloid cascade hypothesis, which postulates that the accumulation of the amyloid-β (Aβ) peptide triggers neuronal death and dementia. However, most drugs that aim to prevent Aβ accumulation or tau phosphorylation have consistently failed in clinical trials. This would suggest that the amyloid pathology lies downstream of (an)other cellular event(s) that is/are responsible for AD pathogenesis. In this context, several lipid alterations have been described in the brain and in peripheral fluids of patients with AD, suggesting the involvement of lipids in the etiology of this condition. Indeed, the central nervous system (CNS) has the highest lipid content in the body, next to adipose tissue, and it is thought that normalization of brain membrane lipid levels would revert AD-related pathogenic events. In this sense, novel hydroxylated derivatives of docosahexaenoic acid (DHA) such as natural resolvins or synthetic hydroxy-DHA (HDHA, DHALifort) can modulate membrane lipid composition and show remarkable beneficial effects on AD hallmarks, such as prevention of amyloid production and tau phosphorylation, and cognitive restoration in animal models. Therefore, normalization of the neuronal lipid environment by hydroxyl-DHA and/or other lipids may constitute a promising therapy for AD treatment, memory loss and, possibly, other types of dementia.",signatures:"Manuel Torres, Xavier Busquets and Pablo V. Escribá",downloadPdfUrl:"/chapter/pdf-download/52003",previewPdfUrl:"/chapter/pdf-preview/52003",authors:[{id:"184164",title:"Prof.",name:"Pablo",surname:"Escribá",slug:"pablo-escriba",fullName:"Pablo Escribá"},{id:"191108",title:"Prof.",name:"Xavier",surname:"Busquets",slug:"xavier-busquets",fullName:"Xavier Busquets"},{id:"191260",title:"Dr.",name:"Manuel",surname:"Torres",slug:"manuel-torres",fullName:"Manuel Torres"}],corrections:null},{id:"52048",title:"Beta Amyloid Peptides: Extracellular and Intracellular Mechanisms of Clearance in Alzheimer’s Disease",doi:"10.5772/64744",slug:"beta-amyloid-peptides-extracellular-and-intracellular-mechanisms-of-clearance-in-alzheimer-s-disease",totalDownloads:2215,totalCrossrefCites:4,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia, characterized by the overproduction and accumulation of different amyloid-β peptide peptides (Aβ) within different areas in the brain conducting to memory loss and dementia. The Aβ cascade hypothesis of AD was originally proposed by Selkoe in 1991 by the theory that accumulation of Aβ42 is the initial trigger for neurodegeneration. The Aβ cascade hypothesis assumes that changes in the production or accumulation of Aβ are responsible for AD pathology. Different Aβ clearance mechanisms are also affected by AD pathology. Studies from the past years have revealed that the blocking of Aβ production is not effective for reducing the brain Aβ levels. However, the relevance of Aβ clearance in AD, especially in late-onset sporadic AD (LOAD), has been heightened, and the study of the Aβ clearance mechanisms has elucidated new possible therapeutic targets. This chapter summarizes recent data underlying the idea of the reduced Aβ clearance and subsequent Aβ spread in AD. We discuss the Aβ clearance mechanisms altered in AD, and the Aβ clearance through autophagy in more detail, a more recent mechanism proposed, and the new strategies to eliminate Aβ42 inducing autophagy.",signatures:"Luis F. Hernández-Zimbrón, Elisa Gorostieta-Salas, Mei-Li Díaz-\nHung, Roxanna Pérez-Garmendia, Gohar Gevorkian and Hugo\nQuiroz-Mercado",downloadPdfUrl:"/chapter/pdf-download/52048",previewPdfUrl:"/chapter/pdf-preview/52048",authors:[{id:"75951",title:"BSc.",name:"Hugo",surname:"Quiroz-Mercado",slug:"hugo-quiroz-mercado",fullName:"Hugo Quiroz-Mercado"},{id:"181180",title:"Dr.",name:"Luis Fernando",surname:"Hernandez-Zimbron",slug:"luis-fernando-hernandez-zimbron",fullName:"Luis Fernando Hernandez-Zimbron"},{id:"181277",title:"Dr.",name:"Roxanna",surname:"Pérez-Garmendia",slug:"roxanna-perez-garmendia",fullName:"Roxanna Pérez-Garmendia"},{id:"181278",title:"BSc.",name:"Elisa",surname:"Gorostieta-Salas",slug:"elisa-gorostieta-salas",fullName:"Elisa Gorostieta-Salas"},{id:"181279",title:"MSc.",name:"Mei-Li",surname:"Díaz-Hung",slug:"mei-li-diaz-hung",fullName:"Mei-Li Díaz-Hung"},{id:"190226",title:"Dr.",name:"Gohar",surname:"Gevorkian-Markosian",slug:"gohar-gevorkian-markosian",fullName:"Gohar Gevorkian-Markosian"}],corrections:null},{id:"52062",title:"Alzheimer's Disease: From Animal Models to the Human Syndrome",doi:"10.5772/64619",slug:"alzheimer-s-disease-from-animal-models-to-the-human-syndrome",totalDownloads:2279,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Some animal models, genetically modified (such as murine) and sporadic (as others species), enable the study of the origin of specific lesions observed in human neurodegenerative diseases. In particular, Alzheimer's disease (AD) models have been designed to test the hypothesis that certain lesions are associated with functional and morphological changes beginning with memory loss and impairment in activities of daily life. This review compares and evaluates the phenotypes of different AD animal models, on the basis of the specific objectives of each study, with the purpose of encompassing their contributions to the comprehension of the AD signs and symptoms in humans. All these models contribute to the comprehension of the human AD mechanisms regarding the heterogeneity of AD phenotypes: the overlap between AD and age‐related changes, the variability of AD onset (early or late), the probable reactiveness of amyloid‐β and tau proteins, the scarcity of senile plaques and/or neurofibrillary tangles in some AD cases, the spatial correlation of the pathology and cerebral blood vessels, and the immunological responses (microglial aging) and synaptopathy. Altogether, these considerations may contribute to find therapies to treat and prevent this disease.",signatures:"Erika Orta‐Salazar, Isaac Vargas‐Rodríguez, Susana A Castro‐\nChavira, Alfredo I. Feria‐Velasco and Sofía Díaz‐Cintra",downloadPdfUrl:"/chapter/pdf-download/52062",previewPdfUrl:"/chapter/pdf-preview/52062",authors:[{id:"184728",title:"Dr.",name:"Erika Maria",surname:"Orta Salazar",slug:"erika-maria-orta-salazar",fullName:"Erika Maria Orta Salazar"},{id:"185118",title:"Ph.D. Student",name:"Isaac",surname:"Vargas-Rodríguez",slug:"isaac-vargas-rodriguez",fullName:"Isaac Vargas-Rodríguez"},{id:"185119",title:"Ph.D. Student",name:"Susana Angelica",surname:"Castro-Chavira",slug:"susana-angelica-castro-chavira",fullName:"Susana Angelica Castro-Chavira"},{id:"185120",title:"Ph.D.",name:"Alfredo I",surname:"Feria-Velasco",slug:"alfredo-i-feria-velasco",fullName:"Alfredo I Feria-Velasco"},{id:"185121",title:"Ph.D.",name:"Sofia",surname:"Diaz-Cintra",slug:"sofia-diaz-cintra",fullName:"Sofia Diaz-Cintra"}],corrections:null},{id:"51441",title:"Risk Factors for Alzheimer’s Disease",doi:"10.5772/64270",slug:"risk-factors-for-alzheimer-s-disease",totalDownloads:1742,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Alzheimer’s disease (AD) is the most common form of dementia in the elderly. Currently there is no effective treatment available. Senile plaques and neurofibrillary tangles are hallmarks of AD pathology, and patients demonstrate cognitive complaints with deficits in various neuropsychological domains. Familial AD (FAD) accounts for 0.5% of all AD cases and usually presents before the age of 65 years. Approximately 50% of the FAD patients carry mutations in one of the following genes: APP, PSEN1, and PSEN2. Inheriting any of these genetic mutations increases Aβ42 production, which has been linked to AD pathogenesis. Late-onset AD represents the majority of AD cases, with evidence suggesting impaired Aβ clearance. However, the etiology of late-onset AD is more complex. Several findings suggest that multiple risk genes and factors may contribute to the pathogenesis of LOAD. In this chapter, we elaborate some of these factors and their involvements in the development of AD.",signatures:"Dongming Cai and Farida El Gaamouch",downloadPdfUrl:"/chapter/pdf-download/51441",previewPdfUrl:"/chapter/pdf-preview/51441",authors:[{id:"183531",title:"Prof.",name:"Dongming",surname:"Cai",slug:"dongming-cai",fullName:"Dongming Cai"},{id:"183867",title:"Dr.",name:"Farida",surname:"El Gaamouch",slug:"farida-el-gaamouch",fullName:"Farida El Gaamouch"}],corrections:null},{id:"51355",title:"Normal Aging and Dementia",doi:"10.5772/64203",slug:"normal-aging-and-dementia",totalDownloads:1850,totalCrossrefCites:6,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Normal aging begins after 60 years of age. According to Harman, the accumulation of free radicals, which results from weakening of repair and protective mechanisms, takes place in the aging brain. It is believed that especially in the population of the most elderly there is increased incidence of both dementia and depression. The causes of these central nervous system disorders in the aging human body are changes at the molecular level, such as changes in the biochemical parameters, the accumulation of mutations in nuclear and mitochondrial DNA, and epigenetic changes. Biomarkers associated with aging of the brain include accumulated deposits of β-amyloid (Aβ), disturbed cholesterol homeostasis, altered neuroimaging parameters, and impaired glucose metabolism. Genetic factors are also responsible for normal aging, for example, SIRT1, AKT1, and CDKN1A, and among them the longevity genes, such as FOXO3A and CETP. Dementia as well as cognitive decline may be modified by poly-T variants of TOMM40 and APOE alleles via influencing the level of apolipoprotein E (apoE) in the brain and in the plasma as well as by its ability of Aβ clearance.",signatures:"Michał Prendecki, Jolanta Florczak-Wyspianska, Marta Kowalska,\nMargarita Lianeri, Wojciech Kozubski and Jolanta Dorszewska",downloadPdfUrl:"/chapter/pdf-download/51355",previewPdfUrl:"/chapter/pdf-preview/51355",authors:[{id:"31962",title:"Dr.",name:"Jolanta",surname:"Dorszewska",slug:"jolanta-dorszewska",fullName:"Jolanta Dorszewska"},{id:"83372",title:"Prof.",name:"Wojciech",surname:"Kozubski",slug:"wojciech-kozubski",fullName:"Wojciech Kozubski"},{id:"183236",title:"Dr.",name:"Jolanta",surname:"Florczak-Wyspianska",slug:"jolanta-florczak-wyspianska",fullName:"Jolanta Florczak-Wyspianska"},{id:"186409",title:"MSc.",name:"Michal",surname:"Prendecki",slug:"michal-prendecki",fullName:"Michal Prendecki"},{id:"186528",title:"MSc.",name:"Marta",surname:"Kowalska",slug:"marta-kowalska",fullName:"Marta Kowalska"},{id:"186529",title:"Dr.",name:"Margarita",surname:"Lianeri",slug:"margarita-lianeri",fullName:"Margarita Lianeri"}],corrections:null},{id:"52137",title:"Changes in Visual Cortex in Healthy Aging and Dementia",doi:"10.5772/64562",slug:"changes-in-visual-cortex-in-healthy-aging-and-dementia",totalDownloads:1685,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"This chapter reviews the differences in specific structural and functional characteristics of human visual cortex among young adults, healthy aging adults, and patients with dementia, with a primary focus on those with Alzheimer’s disease (AD). Such visual cortex changes have been shown to underlie many of the behavioral deficits that develop in healthy aging and AD. Measurements of disordered visual cortex in dementia patients may be possible early in the course of neurodegeneration and thus may be useful for improving early diagnosis of these devastating diseases.",signatures:"Alyssa A. Brewer and Brian Barton",downloadPdfUrl:"/chapter/pdf-download/52137",previewPdfUrl:"/chapter/pdf-preview/52137",authors:[{id:"115304",title:"Dr.",name:"Alyssa",surname:"Brewer",slug:"alyssa-brewer",fullName:"Alyssa Brewer"},{id:"149246",title:"Dr.",name:"Brian",surname:"Barton",slug:"brian-barton",fullName:"Brian Barton"}],corrections:null},{id:"52368",title:"Clusterin (APOJ) in Alzheimer’s Disease: An Old Molecule with a New Role",doi:"10.5772/64233",slug:"clusterin-apoj-in-alzheimer-s-disease-an-old-molecule-with-a-new-role",totalDownloads:2207,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Clusterin (CLU), initially identified in 1983 as a “clustering factor” in ram rete testis fluid, is a multifaceted protein that was re-discovered and subsequently renamed eight times from 1983 to 1992. CLU exists as multiple protein isoforms including the 80 kDa glycosylated mature/secreted form of CLU (mCLU) and the smaller non-modified nuclear and intracellular forms of CLU (nCLU and icCLU, respectively). These isoforms, which are expressed at the highest levels in the brain, are suggested to play distinct roles in various disease processes such as those involving inflammation and apoptosis. Currently, CLU, also known as apolipoprotein J (APOJ) which belongs to the same protein family as apolipoprotein E (APOE), is the third most significant genetic risk factor for the development of late-onset Alzheimer’s disease (LOAD); however, an extensive gap exists in the literature in understanding the physiological roles of CLU in normal brain and the pathogenic mechanisms conferred by CLU polymorphisms in the onset of LOAD. In this chapter, we discuss the status of the current knowledge regarding the generation and regulation of CLU protein isoforms, the clinical evidence and possible mechanisms involved in LOAD, and provide our perspectives for future studies.",signatures:"Sarah K. Woody and Liqin Zhao",downloadPdfUrl:"/chapter/pdf-download/52368",previewPdfUrl:"/chapter/pdf-preview/52368",authors:[{id:"182716",title:"Prof.",name:"Liqin",surname:"Zhao",slug:"liqin-zhao",fullName:"Liqin Zhao"},{id:"187597",title:"Ms.",name:"Sarah",surname:"Woody",slug:"sarah-woody",fullName:"Sarah Woody"}],corrections:null},{id:"51440",title:"New Targets for Diagnosis and Treatment Against Alzheimer’s Disease: The Mitochondrial Approach",doi:"10.5772/64327",slug:"new-targets-for-diagnosis-and-treatment-against-alzheimer-s-disease-the-mitochondrial-approach",totalDownloads:2089,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. AD is characterized by brain presence of senile plaques, which are formed by aggregates of Aβ peptide and neurofibrillary tangles (NFTs), formed by pathological forms of tau protein. Evidence suggests that these elements affect neurons compromising energy supply, antioxidant response and synaptic activity. AD principally affects the memory and cognitive functions of the patients, and currently, successful strategies for diagnosis and early treatment are lacking. In this scenario, accumulative evidence suggests that mitochondrial dysfunction precedes the establishment of tau and Aβ pathology and contributes to synaptic degeneration observed in AD. Therefore, reducing mitochondrial injury may have beneficial effects for neuronal dysfunction and cognitive decline observed in AD patients. Interestingly, the examination of peripheral cells from AD patients also presents mitochondrial dysfunction, suggesting that tracking these mitochondrial defects in peripheral cells could be a potential mechanism of early diagnosis of AD. In this chapter, we analyse current evidence that suggests that mitochondrial injury is an important factor in the pathogenesis of AD and how studying this process could reveal new strategies to mitigate neurodegeneration and to develop new diagnostic methods for an early detection of AD.",signatures:"María José Pérez, Claudia Jara, Ernesto Muñoz‐Urrutia and Rodrigo\nA. Quintanilla",downloadPdfUrl:"/chapter/pdf-download/51440",previewPdfUrl:"/chapter/pdf-preview/51440",authors:[{id:"182849",title:"Dr.",name:"Rodrigo",surname:"Quintanilla",slug:"rodrigo-quintanilla",fullName:"Rodrigo Quintanilla"},{id:"183872",title:"MSc.",name:"María José",surname:"Pérez",slug:"maria-jose-perez",fullName:"María José Pérez"},{id:"183873",title:"Dr.",name:"Claudia",surname:"Jara",slug:"claudia-jara",fullName:"Claudia Jara"},{id:"183874",title:"MSc.",name:"Ernesto",surname:"Muñoz",slug:"ernesto-munoz",fullName:"Ernesto Muñoz"}],corrections:null},{id:"51819",title:"The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up",doi:"10.5772/64490",slug:"the-impact-of-the-eye-in-dementia-the-eye-and-its-role-in-diagnosis-and-follow-up",totalDownloads:2909,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Over the last few decades, the importance of ophthalmic examination in neurodegenerative diseases of the CNS has reportedly increased. The retina is an extension of the CNS and thus should not be surprising to find abnormal results in both the test exploring visual processing and those examining the retina of patients with CNS degeneration. Current in vivo imaging techniques are allowing ophthalmologists to detect and quantify data consistent with the histopathological findings described in the retinas of Alzheimer’s disease (AD) patients and may help to reveal unsuspected retinal and optic‐nerve repercussions of other CNS diseases. In this chapter, we perform an analysis of the physiological changes in ocular and cerebral ageing. We analyse the ocular manifestations in CNS disorders such as stroke, AD and Parkinson’s disease. In addition, the pathophysiology of both the eye and the visual pathway in AD are described. The value of the visual psychophysical tests in AD diagnosis is reviewed as well as the main findings of the optical coherence tomography as a contribution to the diagnosis and monitoring of the disease. Finally, we examine the association of two neurodegenerative diseases, AD and glaucoma, as mere coincidence or possible role in the progression of the neurodegeneration.",signatures:"Elena Salobrar‐García, Ana I. Ramírez, Rosa de Hoz, Pilar Rojas, Juan\nJ. Salazar, Blanca Rojas, Raquel Yubero, Pedro Gil, Alberto Triviño\nand José M. Ramírez",downloadPdfUrl:"/chapter/pdf-download/51819",previewPdfUrl:"/chapter/pdf-preview/51819",authors:[{id:"142707",title:"Prof.",name:"José M.",surname:"Ramírez",slug:"jose-m.-ramirez",fullName:"José M. Ramírez"},{id:"142864",title:"Prof.",name:"Alberto",surname:"Triviño",slug:"alberto-trivino",fullName:"Alberto Triviño"},{id:"145761",title:"Prof.",name:"Juan J",surname:"Salazar",slug:"juan-j-salazar",fullName:"Juan J Salazar"},{id:"145765",title:"Prof.",name:"Rosa",surname:"De Hoz",slug:"rosa-de-hoz",fullName:"Rosa De Hoz"},{id:"145766",title:"Prof.",name:"Blanca",surname:"Rojas",slug:"blanca-rojas",fullName:"Blanca Rojas"},{id:"145767",title:"Prof.",name:"Ana I.",surname:"Ramírez",slug:"ana-i.-ramirez",fullName:"Ana I. Ramírez"},{id:"183853",title:"MSc.",name:"Elena",surname:"Salobrar-García",slug:"elena-salobrar-garcia",fullName:"Elena Salobrar-García"},{id:"183854",title:"MSc.",name:"Pilar",surname:"Rojas",slug:"pilar-rojas",fullName:"Pilar Rojas"},{id:"183858",title:"Dr.",name:"Pedro",surname:"Gil",slug:"pedro-gil",fullName:"Pedro Gil"},{id:"183859",title:"Dr.",name:"Raquel",surname:"Yubero",slug:"raquel-yubero",fullName:"Raquel Yubero"}],corrections:null},{id:"52006",title:"Caring for Individuals with Dementia on a Continuum: An Interdisciplinary Approach Between Music Therapy and Nursing",doi:"10.5772/64663",slug:"caring-for-individuals-with-dementia-on-a-continuum-an-interdisciplinary-approach-between-music-ther",totalDownloads:3845,totalCrossrefCites:1,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Background: Music has long been used to ease symptoms of dementia. Several studies have shown the therapeutic benefits of music therapy to decrease symptoms of agitation in people with dementia (PWD). Other research has demonstrated that the use of music during caregiving can ease agitated behaviors. However, few studies have shown the clinical benefits of using translational research in practice between music therapists and certified nursing assistants.",signatures:"Kendra Ray, Ayelet Dassa, Jan Maier, Renita Davis and Olayinka\nOgunlade",downloadPdfUrl:"/chapter/pdf-download/52006",previewPdfUrl:"/chapter/pdf-preview/52006",authors:[{id:"183246",title:"Dr.",name:"Kendra",surname:"Ray",slug:"kendra-ray",fullName:"Kendra Ray"},{id:"183915",title:"Prof.",name:"Renita",surname:"Davis",slug:"renita-davis",fullName:"Renita Davis"},{id:"183916",title:"Ms.",name:"Jan",surname:"Maier",slug:"jan-maier",fullName:"Jan Maier"},{id:"184382",title:"Dr.",name:"Ayelet",surname:"Dassa",slug:"ayelet-dassa",fullName:"Ayelet Dassa"},{id:"184383",title:"Mr.",name:"Olayinka",surname:"Ogunlade",slug:"olayinka-ogunlade",fullName:"Olayinka Ogunlade"}],corrections:null},{id:"52128",title:"Behavior and Emotion in Dementia",doi:"10.5772/64681",slug:"behavior-and-emotion-in-dementia",totalDownloads:1817,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"During the course of disease, the patient and caregiver face emotional and behavioral problems that may occur. Therefore, it is important to knowing how emotions and the perception of them are modified and thus to know the impact they have on mood and behavior of the patient and caregiver. Publicizing the type of pathology, both emotional and behavioral levels, in a patient with dementia can help in the development of nonpharmacological interventions that could slow the symptoms and improve the quality of life of patients.",signatures:"Teresa Mayordomo Rodríguez, Alicia Sales Galán, Rita Redondo\nFlores, Marta Torres Jordán and Javier Bendicho Montes",downloadPdfUrl:"/chapter/pdf-download/52128",previewPdfUrl:"/chapter/pdf-preview/52128",authors:[{id:"184060",title:"Dr.",name:"Teresa",surname:"Mayordomo Rodríguez",slug:"teresa-mayordomo-rodriguez",fullName:"Teresa Mayordomo Rodríguez"},{id:"370127",title:"Dr.",name:"Alicia Sales",surname:"Galán",slug:"alicia-sales-galan",fullName:"Alicia Sales Galán"},{id:"370128",title:"Dr.",name:"Rita Redondo",surname:"Flores",slug:"rita-redondo-flores",fullName:"Rita Redondo Flores"},{id:"370129",title:"Dr.",name:"Marta Torres",surname:"Jordán",slug:"marta-torres-jordan",fullName:"Marta Torres Jordán"},{id:"370130",title:"Dr.",name:"Javier Bendicho",surname:"Montes",slug:"javier-bendicho-montes",fullName:"Javier Bendicho Montes"}],corrections:null},{id:"51705",title:"Non-Pharmacological Approaches in the Treatment of Dementia",doi:"10.5772/64232",slug:"non-pharmacological-approaches-in-the-treatment-of-dementia",totalDownloads:2756,totalCrossrefCites:3,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Currently, a pharmacological disease-modifying treatment for dementia is not available, but different non-pharmacological approaches appear to be useful. In this chapter, we describe traditional treatments such as cognitive and emotion-oriented interventions, sensory and multi-sensory stimulation interventions and also potentially alternative interesting options such as behavioural therapy, animal-assisted therapy, home-adaptation therapy and assistive technologies to support patient with dementia. Many non-pharmacological treatments have reported benefits in multiple research studies, but there is a need for further Randomized controlled trials (RCTs) with an adequate sample size to improve the strength of evidence in order to apply these approaches.",signatures:"Grazia D’Onofrio, Daniele Sancarlo, Davide Seripa, Francesco\nRicciardi, Francesco Giuliani, Francesco Panza and Antonio Greco",downloadPdfUrl:"/chapter/pdf-download/51705",previewPdfUrl:"/chapter/pdf-preview/51705",authors:[{id:"184079",title:"Dr.",name:"Daniele",surname:"Sancarlo",slug:"daniele-sancarlo",fullName:"Daniele Sancarlo"},{id:"184081",title:"Dr.",name:"Antonio",surname:"Greco",slug:"antonio-greco",fullName:"Antonio Greco"},{id:"272620",title:"Dr.",name:"Davide",surname:"Seripa",slug:"davide-seripa",fullName:"Davide Seripa"},{id:"272628",title:"Dr.",name:"Grazia",surname:"D'Onofrio",slug:"grazia-d'onofrio",fullName:"Grazia D'Onofrio"},{id:"368922",title:"Dr.",name:"Francesco",surname:"Ricciardi",slug:"francesco-ricciardi",fullName:"Francesco Ricciardi"},{id:"368923",title:"Dr.",name:"Francesco",surname:"Giuliani",slug:"francesco-giuliani",fullName:"Francesco Giuliani"},{id:"368924",title:"Dr.",name:"Francesco",surname:"Panza",slug:"francesco-panza",fullName:"Francesco Panza"}],corrections:null},{id:"52095",title:"Medication Management for People Living with Dementia: Development and Evaluation of a Multilingual Information Resource for Family Caregivers of People Living with Dementia",doi:"10.5772/64661",slug:"medication-management-for-people-living-with-dementia-development-and-evaluation-of-a-multilingual-i",totalDownloads:1704,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The aim of this chapter is to describe the development and evaluation of an online multilingual information resource focused on medication management, targeting people living with dementia and their family caregivers. Maintaining effective medication management is important to allow ongoing quality of life within the community setting and avoiding medication-related preventable hospitalisations for the person living with dementia. Family caregivers are likely to assume the role of medication management on behalf of the person in their care as dementia progresses. Little training or information is available to family caregivers to assist them with this role. A pilot online information resource was developed and evaluated. Responding to the evaluation, this resource was improved, and a more extensive evaluation process was undertaken. The development and evaluation process are outlined with a view to guiding the development of similar resources, especially those targeting linguistically diverse family caregivers and those with dementia. This is especially important given that many older adults will migrate during their lifetime, often to a country where they are not familiar with the language or health services. Extra support is needed to assist older immigrants who are themselves at risk or are caring for someone with dementia.",signatures:"Robyn Gillespie, Pippa Burns, Lindsey Harrison, Amanda Baker, Khin\nWin, Victoria Traynor and Judy Mullan",downloadPdfUrl:"/chapter/pdf-download/52095",previewPdfUrl:"/chapter/pdf-preview/52095",authors:[{id:"183243",title:"Mrs.",name:"Robyn",surname:"Gillespie",slug:"robyn-gillespie",fullName:"Robyn Gillespie"},{id:"190390",title:"Dr.",name:"Pippa",surname:"Burns",slug:"pippa-burns",fullName:"Pippa Burns"},{id:"190391",title:"Dr.",name:"Judy",surname:"Mullan",slug:"judy-mullan",fullName:"Judy Mullan"},{id:"190392",title:"Dr.",name:"Lindsey",surname:"Harrison",slug:"lindsey-harrison",fullName:"Lindsey Harrison"},{id:"190393",title:"Dr.",name:"Amanda",surname:"Baker",slug:"amanda-baker",fullName:"Amanda Baker"},{id:"190394",title:"Dr.",name:"Khin",surname:"Win",slug:"khin-win",fullName:"Khin Win"},{id:"190395",title:"Dr.",name:"Victoria",surname:"Traynor",slug:"victoria-traynor",fullName:"Victoria Traynor"}],corrections:null},{id:"52044",title:"Diabetes Mellitus and Depression as Risk Factors for Dementia: SADEM Study",doi:"10.5772/64678",slug:"diabetes-mellitus-and-depression-as-risk-factors-for-dementia-sadem-study",totalDownloads:1513,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Aim: 3Evidence indicates that the comorbidity of dementia with diabetes and depression may affect most cognitive functions. Our chief interest was to examine the patterns of cognitive functioning in individuals diagnosed with dementia, diabetes, and depression as compared with dementia plus diabetes (DDM), or dementia plus depression (DD) and healthy controls.",signatures:"Juárez‐Cedillo Teresa, Hsiung Ging‐Yuek, Sepehry A. Amir, Beattie\nB. Lynn, Jacova Claudia and Escobedo de la Peña Jorge",downloadPdfUrl:"/chapter/pdf-download/52044",previewPdfUrl:"/chapter/pdf-preview/52044",authors:[{id:"183147",title:"Dr.",name:"Teresa",surname:"Juarez-Cedillo",slug:"teresa-juarez-cedillo",fullName:"Teresa Juarez-Cedillo"},{id:"187568",title:"Dr.",name:"Ging-Yuek",surname:"Hsiung",slug:"ging-yuek-hsiung",fullName:"Ging-Yuek Hsiung"},{id:"187569",title:"Dr.",name:"Amir",surname:"Sepehry",slug:"amir-sepehry",fullName:"Amir Sepehry"},{id:"187570",title:"MSc.",name:"B. Lynn",surname:"Beattie",slug:"b.-lynn-beattie",fullName:"B. Lynn Beattie"},{id:"187571",title:"Dr.",name:"Claudia",surname:"Jacova",slug:"claudia-jacova",fullName:"Claudia Jacova"},{id:"187572",title:"Dr.",name:"Jorge",surname:"Escobedo De La Peña",slug:"jorge-escobedo-de-la-pena",fullName:"Jorge Escobedo De La Peña"}],corrections:null},{id:"51311",title:"Idiopathic Normal Pressure Hydrocephalus: An Overview of Pathophysiology, Clinical Features, Diagnosis and Treatment",doi:"10.5772/64198",slug:"idiopathic-normal-pressure-hydrocephalus-an-overview-of-pathophysiology-clinical-features-diagnosis-",totalDownloads:2939,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Normal pressure hydrocephalus is characterised by the triad of gait disturbance, dementia and urinary incontinence. Although our understanding of the condition has considerably improved since it was initially described over 50 years ago, its pathophysiology is still a matter of debate. We provide an overview of the current concepts in pathophysiology and discuss the clinical features, diagnosis and treatment of this cause of dementia.",signatures:"Rubesh Gooriah and Ashok Raman",downloadPdfUrl:"/chapter/pdf-download/51311",previewPdfUrl:"/chapter/pdf-preview/51311",authors:[{id:"183615",title:"Dr.",name:"Rubesh",surname:"Gooriah",slug:"rubesh-gooriah",fullName:"Rubesh Gooriah"},{id:"367770",title:"Dr.",name:"Ashok",surname:"Raman",slug:"ashok-raman",fullName:"Ashok Raman"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"673",title:"Dyslexia",subtitle:"A Comprehensive and International Approach",isOpenForSubmission:!1,hash:"9a88d127d035ab53de96a00f9ed407ba",slug:"dyslexia-a-comprehensive-and-international-approach",bookSignature:"Taeko N. Wydell and Liory Fern-Pollak",coverURL:"https://cdn.intechopen.com/books/images_new/673.jpg",editedByType:"Edited by",editors:[{id:"87489",title:"Prof.",name:"Taeko",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2646",title:"Visual Cortex",subtitle:"Current Status and Perspectives",isOpenForSubmission:!1,hash:"8a5632344dfe9b3f0153eeee84a6ea83",slug:"visual-cortex-current-status-and-perspectives",bookSignature:"Stephane Molotchnikoff and Jean Rouat",coverURL:"https://cdn.intechopen.com/books/images_new/2646.jpg",editedByType:"Edited by",editors:[{id:"145800",title:"Prof.",name:"Stephane",surname:"Molotchnikoff",slug:"stephane-molotchnikoff",fullName:"Stephane Molotchnikoff"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2604",title:"Basal Ganglia",subtitle:"An Integrative View",isOpenForSubmission:!1,hash:"76d19f809182eea657ce36eb4817c5b8",slug:"basal-ganglia-an-integrative-view",bookSignature:"Fernando A. Barrios and Clemens Bauer",coverURL:"https://cdn.intechopen.com/books/images_new/2604.jpg",editedByType:"Edited by",editors:[{id:"147924",title:"Dr.",name:"Fernando A.",surname:"Barrios",slug:"fernando-a.-barrios",fullName:"Fernando A. 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In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. 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However, disastrous impacts of 1945 Makran Tsunami, which occurred in the Arabian Sea merely 70 years ago, cannot be ignored and urge need of comprehensive and sustained tsunami resilience efforts.
In recent decades, 2004 Indian Ocean and 2011 Japan Tsunamis have revealed destructing powers of tsunami and the level of unpreparedness with regard to hazard assessment, warning and response planning, public awareness, mitigation, and research, not only of developing but developed countries as well.
Since 2006, in the aftermath of 2004 Indian Ocean Tsunami, significant efforts have been made in the country; however, there is much more to do for developing tsunami-resilient communities in Pakistan.
There are several multi-tiered stakeholders having inter-reliant responsibilities and mandates for earthquake and tsunami risk reduction, working in the coastal region of Pakistan. There is a need to support those stakeholders in dealing with tsunami and earthquake risks in a well-coordinated and comprehensive manner. This chapter recommends policy guidelines for determining strategic significance of posed tsunami threat to the Pakistan coast and ascertaining the underlying risks in comparison to the current capacities and preparedness measures. The chapter also suggests desirable research work, establishing timely warning system and structural and nonstructural mitigation measures including effective outreach to the public level and international coordination to combat local tsunami threat.
The Arabian Sea region is threatened by earthquake and tsunami hazards, mainly because of the presence of the Makran subduction zone (MSZ). An earthquake of magnitude 8+ had wreaked havoc along the Pakistan coastline on 28 November 1945 followed by a devastating tsunami. In contrast to the level of posed threat and multiple-fold increase in vulnerabilities since then, the risk mitigation efforts are trivial and least coordinated. There is need for stakeholders to provide a set of prerequisite information to develop their organizational strategies and course of action for earthquake and tsunami risk mitigation in a well-coordinated manner, from local to the national level. Most important and immediate tasks include:
Develop standardized and coordinated tsunami hazard and risk assessments for all coastal regions of Sindh and Baluchistan provinces.
Improve tsunami and seismic sensor data, infrastructure, and standard operating procedures (SOPs) for better tsunami detection and warning.
Enhance tsunami forecast and warning dissemination capability along the coastline.
Promote the development of model mitigation measures, and encourage communities to adopt resilient construction, critical facilities protection, and land-use planning practices to reduce the impact of future tsunamis.
Increase outreach to all communities, including all demographics of the at-risk population, to raise awareness, improve preparedness, and encourage the development of tsunami response plans.
Develop a strategic plan for earthquake- and tsunami-related research especially within Arabian Sea region.
The required mitigation measures in a standardized manner are divided into three main categories including hazard assessment, risk evaluation, and mitigating measures to guide national level stakeholders in developing a long-term comprehensive tsunami response and risk reduction plan for Pakistan.
Establishing a technical committee to perform a role of central coordination and advisory under the National Disaster Management Authority can be supportive for stakeholders interested in and mandated for planning and implementation of earthquake and tsunami response and preparedness measures.
This section is based on the review of scientific and historical evidences of various potential sources of tsunamis which have affected and are likely to affect the Arabian Sea region and are described below.
The most important source of earthquake-generated fast-approaching tsunamis (a local tsunami) in the Arabian Sea is the Makran subduction zone (Figure 1) adjacent to the coasts of Iran and Pakistan [1]. Recent event, known as 1945 Makran Tsunami, was caused by the earthquake in eastern part of this zone.
General location map of the Makran subduction zone (MSZ) at the northwestern Indian Ocean showing locations of past tsunamis in the region. Source tsunami risk, preparedness and warning system in Pakistan by Heidarzadeh [
Another potential subduction zone lies from the northern tip of the Bay of Bengal, through the western margin of the Andaman Sea, and skirting the southern coasts of Sumatra, Java, and the islands of Lesser Sunda and is underlain geologically as Sunda subduction zone [1]. However, a tsunami generated by a potential earthquake event within Sunda subduction zone may reach Pakistan coast in hours, categorized as distant tsunami. A devastating event like 2004 Indian Ocean tsunami created disturbance on Pakistan coast after several hours of the incident occurred near Indonesia.
It is difficult to evaluate the accurate level of tsunami hazard these subduction zones pose for near and distant regions. The record and likelihood of earthquake occurrence in these zones and the implications for tsunami generation are the only basis for such estimations.
Within the Arabian Sea region, submarine landslides have the potential to produce large, local tsunamis owing to steep seafloor slopes and rapid sedimentation.
Tsunami waves (≤1 m) were observed in the Arabian Sea on 24 September 2013 along several beaches in Oman and Pakistan during low tide period. The event was caused by a secondary effect of an earthquake of magnitude 7.7, which occurred inland in southwestern Pakistan at 11.29.47 UTC (local time is UTC +5) on the same day, but after several hours, the earthquake’s epicenter was a couple of hundred kilometers inland. Hoffman et al. [3] suggest the waves must have been triggered by a submarine landslide.
Tsunami hazard assessment at local level is important to understand the locally imposed threat and to deal with the posed hazard accordingly. The creation of local hazard maps is a key step in the tsunami risk assessment procedure and is needed to:
Develop evacuation plans
Land-use planning within a defined coastal management area
Determine the exposure parameters that will be used in the assessment of vulnerability of the coastal community and of their supporting assets and systems
The organizations, institutions, and experts mandated or interested to conduct directly or support to carry out earthquake and/or tsunami hazard assessment along the Pakistan coastline are suggested to follow standard parameters or guidelines, led by any national agency like the National Disaster Management Authority (NDMA) such as:
Local tsunami hazard maps are usually developed from specified tsunami event scenarios. The parameters defined in Multi-Hazard Vulnerability and Risk Assessment guidelines of the NDMA available at http://ndma.gov.pk/publications/MHVRA%202017.pdf are used [4]. Other technical details for modeling tsunami hazard, for example, input data sources, modeling tools, and criteria used by different research institutions and experts, can also be reviewed by the NDMA to make integrated tsunami hazard assessment of the Pakistan coastline on a standardized format. Final output products include:
Inundation maps
Flow velocity profiles
Warning time available for emergency response
Debris flow profiles at least for ports if possible
Comprehensive hazard map made by overlaying inundation maps and flow velocity profiles
The NDMA take the core responsibility of coordination among agencies and implementing partners to develop and facilitate regular update of hazard database. The NDMA collaboration is also required for statistics and information acquisition and sharing among stakeholders, developing and publishing such maps on standardized and easily understandable (for general public) format.
Interagency coordination for sharing data and information required for comprehensive hazard assessment should be conducted by the NMDA and PDMAs, for example, onshore, offshore surface data, geological and meteorological scientific information, census and building records, and satellite images and archival records. The NDMA being the central focal organization for disaster management can play a vital role to facilitate data and information sharing among organizations and also with researchers.
Tsunami caused by undersea landslides should also be accounted for more reliable hazard assessment process.
All possible impacts of any future tsunami event should also be studied and modeled in details. For example, huge quantities of debris brought onshore itself can be a major hazard for ports, fishing harbors, and local environment at any specific location.
Using the outputs from the hazard assessment, disaster, emergency managers, and other relevant organizations (NDMA, PDMAs, and DDMAs of Baluchistan and Sindh Provinces) will need to create a community asset database of maps showing the distribution of population, buildings, infrastructure, and environmental assets in relation to the information on various hazard exposure parameters (inundation limit, run-up, depth of water, proximity to open coast, inundation and drainage flow velocities, etc.) for a particular earthquake and tsunami hazard scenario [1].
In addition to following the NDMA’s MHVRA guidelines, tsunami vulnerability and capacity assessments are to be carried out in detail. Such risk maps should be interpreted in standardized format of “well-defined categories of risk” from the national to local level.
Hazard maps developed under the proposed guidelines of the previous section can be used to incorporate vulnerability maps and finally produce tsunami risk maps, and those should be communicated to all stakeholders in a systematic way.
Levels of risk are presented in geospatial ways: maps showing the extents of areas with defined “risk categories” as high, medium, and low levels of estimated risks as per the NDMA’s MHVRA guidelines.
Coastal cities being hub of economic activities having national life line infrastructure like ports are also densely populated. The NDMA and other relevant national and provincial agencies should encourage research institutions and experts to prioritize conduction of vulnerability and risk assessments of urban areas on priority basis and its incorporation in the national database. For example, detailed exposure database of 1- to 3-km-wide coastal belt in urban, semi-urban, and rural settlements can be maintained and updated annually by the provincial and district disaster management authorities.
To assure uniformity and speed in the risk assessment process, the following data of interest should be maintained for areas in close proximity to the sea (as suggested above, i.e., 1- to 3-km-wide belt along the coast can be surveyed on priority). Detailed survey should be carried out along the coastal areas to collect data such as:
Census data (population distribution, income, and other statistics such as age, occupation, disability, education)
Building classification, construction materials and techniques, ground level elevation
Critical infrastructure (roads, water, power, sewerage, emergency facilities)
Economic zones and location (business sectors, industry, ports)
Environmental services/inventory
The abovementioned information include all required level sof onshore, offshore surface data, geological and meteorological scientific information, census and building records, satellite images, archival records, and organizational capacity (to facilitate and contribute in earthquake and tsunami emergency response and preparedness).
Data and information collection, for reliable and authenticated coastal earthquake and tsunami risks assessment, can be acquired by all the agencies and organization mandated to collect and maintain such database, whereas the NDMA can play a vital role of coordination and support for essential data sharing among agencies and with experts by developing data sharing protocol.
This section covers guidelines for effective earthquake and tsunami risk reduction measure to strengthen coastal communities and infrastructure aiming to reduce impacts of any devastating event in the future.
Is it critically important to assess whether the current early warning system and practices are effective for the posed tsunami threat to Pakistan coastal communities [5]? A review of critical issues that hindered the efficient and timely operation of early warning systems has led to the identification of four elements [1]:
Implementation of technically oriented early warning systems, without taking into consideration or without conducting risk assessment
Weaknesses in monitoring and forecasting of potentially catastrophic events
Weaknesses in the emission of warnings or in ensuring that warnings reach vulnerable communities
Weaknesses in local capacities to respond to a warning and to a potentially catastrophic event
The National Seismic Monitoring Tsunami Early Warning Center (NSMTEWC) of the Pakistan Meteorological Department (PMD) is capable of issuing warning bulletins and messages to identified stakeholders including disaster management authorities, concerned provincial and district governments, and media within 13 min as specified in laid down standard operating procedures [5]. However, there is a lack of further downstream time bound SOPs (13 min onward with reference to PMD’s SOPs) of other stakeholders (e.g., disaster management authorities, emergency services, provincial and local governments) to ensure the warning information and messages are communicated to all vulnerable coastal communities and, if needed, to adopt evacuation procedures that are timely completed within available lead time.
The NDMA being the central coordinating agency of disaster management in Pakistan can take a lead and engage relevant organization including PDMA Sindh, PDMA Balochistan, Army, Pakistan Navy, Pakistan Coast Guards, Marine Security Agency, port authorities, and police to develop consensus on technical issues, set required protocols, and monitor progress on the policy guidelines mentioned below:
End-to-end time bound synergized SOPs for the dissemination of tsunami warning to be developed involving all stakeholders living in remote coastal villages including islands and creeks.
Protocol among all national organizations capable of communication (using one or more communication networks such as satellite, HF/VHF, radio, or any wired or wireless network) should be established and made accessible to coastal communities (on- and offshore).
Develop and enforce SOPs and procedures to ensure that all tsunami and earthquake detection, forecasting, warning communication, and dissemination network/equipment must be kept in operational condition by the organization in charge of the asset. Such equipment and network should be installed and maintained with earthquake-resistant features and techniques.
Stakeholders and organizations responsible for burden sharing of early warning dissemination can be involved in practicing procedures and equipment operation tests, collectively, at least once a year or on an agreed schedule as a full-scale tsunami exercise in coordination with the NDMA.
Individual government organizations involved in early warning chain and emergency response to arrange tabletop and functional test exercises at least twice a year on a feasible schedule, in coordination with NDMA and/or concerned PDMAs.
Official early warning bulletins should be adapted as easily understandable public messages by relevant PDMA in coordination with the PMD Tsunami Center. The NDMA shall provide central coordination to maintain uniformity and standardization of the public messages.
Early warning bulletins and messages shall be tested for their level of understanding through a manageable size of survey after each simulation, exercise or drill involving the general public or at least schools in target areas.
Strengthening of information sharing mechanism among Regional Tsunami Watch Providers and National Tsunami Warning Centers to better receive information and advice to complement national data stream including seismic, sea level, and other geophysical data networks.
Subject to the assessed level of risk in respect of a tsunami event, disaster management authorities and emergency responders should prioritize establishing and implementing a strategic plan (considering available lead time and resources at local level) for the effective and orderly evacuation of the exposed population.
Evacuation planning in each coastal area is directly related to the:
Geographical size of the management area
Assessed hazards and vulnerabilities
Topography
Demographics
Size and density of the population
Number of agencies involved in the planning process
Resources available
Vulnerability maps derived from the inundation maps (in Section 4) provide key information for evacuation planning. Either voluntary or mandatory evacuation, both can place a significant burden on the resources and emergency managers in terms of caring for the displaced people (Figures 2–5).
Pedestrian tsunami evacuation route at Gwadar City, Baluchistan Province. (Left) Red arrows show starting and ending point of the evacuation route. (Right) Tsunami evacuation route, more than 600 steps of a stairs designed with landing at several points to facilitate pedestrian evacuation leading to the proposed evacuation site at the top of the Koh-e-Batil (a 450 high mountain) by the district disaster management authority Gwadar. Photo by Ghazala Naeem.
Application of engineering solutions of building a protection wall and accommodating the building by raise on stilts to safeguard against maximum tsunami wave and inundation height. Source: IOC Manual 52 [
One of the strategic options for tsunami mitigation is “retreat” with reference to general maximum tsunami wave and inundation height. Source: IOC Manuals and Guides 52 [
Remote coastal communities settled on small islands in the Indus Creek Sindh Province. Photo by Ghazala Naeem.
Disaster management authority of each coastal district, in coordination with concerned stakeholders, should prepare evacuation plans with the following aspects to be addressed:
Identify “at-risk” people/communities who may require evacuation (either through risk assessment (Section 4)). It is recommended that authorities proceed with mapping based on current locally available information and indigenous knowledge and not wait for the perceived required scientific knowledge. Zone boundary definition can then be refined as knowledge improves, over time.
Safe evacuation sites or buildings should be identified, clearly marked, and communicated to locals based on the perceived hazard analysis, for example, possible earthquake shaking, inundation height and extent, etc. Such sites and buildings should be pre-examined for safety, security, required space, and facilities to cater for the expected number of evacuees.
Maps depicting tsunami evacuation zones, escape routes, and tsunami safe areas should be available for display at workplaces, public gathering areas and buildings, holiday homes, and tourist facilities. Particularly, display in all areas subjected to tsunami risk.
Well-placed evacuation signage (in nationally agreed standardized format) with local perspective is critically important, for example, safety instructions and signage (natural signs) for tsunami events, identification of dangerous areas, safe sites, routes to reach evacuation sites, and other important messages.
Define conditions under which an evacuation may be necessary.
Elaborate command, control, and coordination instructions (including designation of officials who are authorized to order an evacuation).
Warning instructions should be issued to the media, public, and businesses.
Procedures for assisting special categories of evacuees (e.g., vulnerable communities with least communication networks, elderly, children, physically challenged people, school students, patients at hospitals, etc.).
Specific plans and procedures that address:
The circumstances of the emergency
Transportation (e.g., arrangements in areas where pedestrian evacuation is not possible or for the patients, etc.)
Dealing with community that disregards mandatory evacuation
The evacuation of specific locations (UC and village level) facilities (ports, hospitals, schools, large industrial setup, atomic reactors, security agencies set-up) and evacuation routes
Means of accounting for evacuees (and registration).
Welfare support for evacuees; designated reception areas for vulnerable groups like unattended children, elderly, patients, physically challenged people, etc.
Security of evacuated areas.
Procedures for the return of evacuees.
A consistent plan to facilitate common public understanding across communities about tsunami evacuation zones, maps, tsunami evacuation signage, and tsunami response actions.
Maintaining the plan, conduct drills and exercises, and incorporate lessons learnt in the overall planning scheme.
Long-term earthquake and tsunami mitigation measures, other than effective early warning system and efficient evacuation plan, are also important to reduce the damage caused on the shores by expected events. There is a wide range of both structural and nonstructural measures, implemented as pre-disaster mitigations to manage earthquake and tsunami risks in the coastal areas of Pakistan.
Within the framework of a coastal area management plan, measures which mitigate the impact of earthquake and tsunami hazard represent a coherent set of interventions. A project monitoring and control system should also be incorporated within such a plan.
This section describes the management of the earthquake and tsunami risk by strategic mitigation, both through the use of structural methods, including the use of natural coastal resources and engineering approaches, and also by nonstructural initiatives, including regulation and land-use, emergency response planning, and community preparedness.
While it is not possible to prevent a tsunami, particularly in tsunami-prone countries, some measures have been implemented and tested to reduce the damage caused on the shores that may have succeeded in slowing down and moderating the impacts of tsunami, for example, construing tsunami in front of populated coastal area, raising ground level for housing near beach by infilling land, and building floodgates and channels to redirect the water from incoming tsunamis. However, their effectiveness has been questioned, as tsunamis are observed there, often higher than the barriers. These engineering options for risk reduction are analyzed, that is, if these are appropriate to the scale of the tsunami threat to the designated coastal area, balancing social and economic pressures against environmental considerations including sustainability, over the long-term.
It is important to have a reliable database of the building stock in coastal areas especially in close proximity of the shoreline to have a reliable vulnerability and thus risk assessment. Strong buildings, safe structures, and prudent land-use policies to save lives and reduce property damage are implemented as pre-disaster mitigation measures.
Relevant disaster management organization and building control authorities should maintain a GIS-based inventory of already constructed buildings with details of construction type, height, use, age, and structural stability at least for the areas in close proximity to shoreline (as a thumb rule, initially this database can be worked out for 1–3-km-wide coastal belt).
Building control authorities in collaboration with other stakeholders should review and suggest policies to counter underlying challenges in the development of disaster resilient built environment. For example, lack of regulatory frameworks, unplanned cities and urbanization, old building stocks and at-risk infrastructure, unauthorized structures, weak institutional arrangements, inadequate capacities of local administration, lack of funding, inadequacy of qualified human resources, corruption, and unlawful activities are major challenges in this regard [6].
Although cost may be an impediment, the national/provincial/local authorities should choose to adopt tsunami-resistant structures, stronger buildings, and deeper shock-resistant foundations mandatory in areas of high risk. The orientation of buildings with respect to the ocean is another factor for consideration. Mandated organizations should develop guidelines, byelaws, regulations, and codes to encourage coastal earthquake and tsunami-resistant infrastructure and housing in a local context. The overall general design guidelines could be developed from the experience gained from post-tsunami impact and damage assessments from different parts of the world as good practices.
Important public buildings, for example, schools, hospitals, and government offices, and infrastructure like telecommunication, communication, water supply, roads, and bridges shall be inspected by the concerned authority for evaluation against estimated earthquake and tsunami impacts. These evaluations shall contribute to the vulnerability and capacity assessments mentioned in Section 4 and completed on priority especially for facilities located within 3-km-wide coastal belt on priority, by the concerned government authority/organization.
A complete framework for strengthening and retrofitting to be prepared and initiated according to available resources and fund generated through public-private partnership schemes.
Information contained in the inundation, vulnerability, and risk maps is to be used as basis to develop policy on land-use planning for new development and to suggest critical measures to make existing land-use better resilient for fast-approaching tsunami [1].
Hazard maps, particularly inundation maps for tsunami scenarios, are appropriate tools to suggest appropriate measure for land-use planning at any particular location. For example, option of “retreat” with reference to expected inundation extents can be used in land-use planning of high-risk areas [1].
Coastal communities in Pakistan, especially in rural settings, tend to settle right on the beach without any appropriate set back distance from the shoreline. Thus, making these settlements much more vulnerable to coastal hazard at one end and an environmental hazard on the other, by throwing sewerage and garbage disposal directly into sea. Such settled remotely in small islands within the Indus creek system, these dotted communities are impossible to be warned in case of approaching local tsunami [5]. Relevant authorities and organization shall establish appropriate land-use management system to ensure a coastal hazard-resilient and environmentally sensitive land-use pattern along the coastline.
Natural coastal features like high lands, sand dunes, mangroves, and other plantation species have been reportedly protecting the nearby communities in disaster situations. For example, interviews of 1945 Makran Tsunami survivors identified Pasni sand dunes, mangroves in Kalmat village, and Indus Creek system, mountain “Koh-e-Batil” at Gwadar, and tens of feet high rocks at Peshukan and Ganz villages as “savior” [7].
Coastal vegetation can be used to dissipate tsunami energy via turbulent flow through the media. The effectiveness of dissipation is dependent on the density of vegetation, its overall porosity, and its tortuous characteristics of porous matrix. It is important to consider that the vegetation itself is resilient against tsunami propagation and has a root structure that can resist the high velocity regime at the floor bed. Planting mangrove at appropriate locations can also serve to dissipate extreme wind wave energy.
Sand dunes can provide natural full barriers against tsunami inundation. When overtopped, sand dunes tend to fail progressively by erosion. Dune-cladding vegetation provides reinforcement to the dunes, thus impeding erosion.
Engineering solution for protection of coastal communities such as offshore breakwaters, dykes, and revetments can be used in hybrid way, i.e., with natural features, harnessing the full potential of coastal ecosystems including coral reefs, sand dunes, and coastal vegetation such as mangrove forests.
Coastal development authorities, forest department, building control authorities, and local and provincial governments need to maintain a database (preferably GIS based) of such natural safeguard features in coastal belt and develop guidelines and regulation to protect and strengthen such features.
Authorities of ports, large- and medium-scale industrial setups, and major facilities, including hospitals, schools, etc., both on- and offshore, need to prepare respective continuity of operation plans in response to estimated earthquake and tsunami impacts mentioned in Sections 3 and 4.
The plan can include [8]:
Conducting business impact analysis.
Identifying recovery time objectives for business processes.
Identifying recovery point objective for restoration.
Define business continuity strategies and requirements.
Work out procedures, resource requirements, and logistics for execution of all recovery strategies.
Describing detailed procedures, resource requirements, and logistics for relocation to alternate work sites.
Deciding detailed procedures, resource requirements, and data restoration plan for the recovery of information technology (networks and required connectivity, servers, desktop/laptops, wireless devices, applications, and data).
National security agencies and port authorities also pay high attention to develop continuity of operation plan.
Tsunamis of even small wave heights can bring huge quantities of debris and waste on the coast. Severe public sanitation and environmental concerns are also associated with earthquake and tsunami debris clearance and the management of municipal solid waste:
District government and municipal committees to develop tsunami debris clearance and waste recovery plan for expected tsunami derived waste estimation made either through numerical modeling or national and international case studies.
National security agencies’ infrastructure and ports need high-level consideration and debris clearance plan.
All agencies and organization including civil defense, fire brigade, Rescue 1122, NDMA, PDMAs, Pakistan Army, Navy, Pakistan Coast Guards, Marine Security Agency, and health department mandated and/or capable of emergency response and rescue operations (even only in case of any critical situation) shall develop or adapt (already available) plans, SOPs, manuals, and guides as per estimated hazard of earthquake and tsunami with reference to Sections 3 and 4.
The abovementioned plan and procedures shall be developed considering lead time availability of only “minutes” before a tsunami can hit the coast. To efficiently act upon the plans, strong coordination (inter and intra department) is to be assured through practicing envisaged plans and participating in scheduled drills and simulations coordinated by the NDMA and PDMAs.
Tsunamis being infrequent phenomena could have gained least focus of all stakeholders in Pakistan; however, mega events of 2004 Indian Ocean tsunami and 2011 Japan tsunami created a sense of realization among national- to local-level organizations and experts to work on tsunami risk assessment and preparedness measures.
Within little more than a decade’s period, significant pilot initiatives on community preparedness have been implemented based upon adaptation of international knowledge products and “Information, Education and Communication” (IEC) material. The adaptation strategy included not only the interpretation of those IEC products in national and local languages but also inclusion of indigenous knowledge and social and cultural traces. Tsunami safety tips, guidance for evacuation, observing natural signs of tsunami, protection, and conservation of natural safeguards of coastal region are delimited in handouts, pamphlets, information boards, booklets, videos, and through radio programs.
The NDMA in collaboration with PDMA Baluchistan and Sindh need to maintain a database of all available IEC material for earthquake and tsunami community preparedness and education.
The NDMA to support PDMAs in finalizing standardization of available knowledge products and further adaptation including translation into local languages.
At local level, DDMAs need to plan and conduct tsunami awareness campaign on yearly basis through training of various community groups (volunteers, teachers, medical staff, local elected representatives, students, women, etc.) and of every Union Councils (UCs).
At national level, NDMA needs to design and implement public awareness campaigns focusing on earthquake and tsunami through national electronic channel and local FM radio channels using the tsunami knowledge database in the coastal region. The NDMA can collaborate with the Pakistan Electronic Media Regulatory Authority (PEMRA) to broadcast such information on electronic media channels under Section 20 (e) “Terms and Condition of License” of PEMRA Ordinance [9].
The NDMA in collaboration with the Pakistan Telecommunication Authority (PTA) can be vital to design and implement tsunami awareness campaigns for general public in coastal region through social media and cellular phone networks.
The NDMA, in collaboration with PDMAs and other government and nongovernment organization, can manage (if already available) and develop (if not readily available) knowledge products on a standardized format for public awareness campaign on the following subjects:
Observing natural signs of tsunami
Receiving and responding official warnings
Identification and recognizing evacuation centers and routes
Information about hazard-resistant construction, land-use, byelaws, regulations and codes to ensure safety against earthquake, tsunami, flooding, and fire impacts
Evacuation procedures and guidelines
Importance of participating in evacuation drills and training
Conservation and strengthening of natural safeguards of tsunami like mangroves, high land, sand dunes, and coral reef.
The information mentioned above shall be used through electronic, print, and social media campaigns and community training.
Evacuation drills must be conducted to ensure training of the community on disciplined evacuation. A regular schedule of conducting drill shall be planned and implemented at local level (UC and village level) once a year with communities settled on the coastline (at least within 3-km-wide coastal belt). PDMAs (Baluchistan and Sindh) shall support respective DDMA to design and implement community-led and sustainable mechanism for monitoring entire processes.
The NDMA in collaboration with PDMAs should lead the process of finalizing curriculum on earthquake, tsunami, flood, cyclone, and fire hazards and preparedness measures for students of all levels. Education departments shall be a part of this process. Private educational institutions also follow the finalized curricula.
Schedule of evacuation drill (at least once a year) in all level academic institutions, both public and private, located in coastal districts shall be finalized by respective DDMA and district education department.
Teachers’ training program to be developed by PDMA Baluchistan and Sindh in collaboration with provincial and coastal districts’ education departments.
Fishing villages in coastal Pakistan along tidal creeks of the Indus Delta and Makran region would need to respond quickly to escape a tsunami from nearby parts of the Makran subduction zone.
The NDMA in collaboration with PDMA Baluchistan and Sindh should conduct a survey and mapping (using GIS) of all remote coastal communities where means of official warning communication are limited or not at all available, in estimated available lead time (subject to the estimated tsunami hazard and risks discussed in Sections 3 and 4).
PDMAs (Baluchistan and Sindh) along with respective DDMAs should design and implement evacuation planning for such communities including:
Identification of feasible evacuation site and routes near each individual settlement.
Awareness campaigns and training of local volunteers to receive official warning to disseminate to other villagers and fishermen.
Interpretation of bulletins issued by the PMD and DDMAs.
Detection of early warning via natural signs such as abnormal behavior of animals, earthquake shaking, and retreat of sea water.
Basic emergency response, especially how and where to evacuate, immediate first aid provision to injured, etc.
Facilitate and mange evacuation of vulnerable groups.
Ways to manage external communication to get help from outside of the village and emergency responders/organization.
Knowing, using, and keeping alive the indigenous knowledge.
Knowledge about different categories of threat and how they should respond to it.
The NDMA in collaboration with PDMAs (Baluchistan and Sindh) and other organizations should develop a strategy to promote insurance (life and property) for earthquake and tsunami incidents that can play an important role in offering financial protection from the costs of disaster.
Understanding disasters and to find appropriate ways to reduce disaster risk are critically important. Scientific, social, and indigenous knowledge-based researches are direly needed to be undertaken, and result sharing with larger audience including communities at risk has a pivotal role in managing disasters. This role of risk-based knowledge sharing has been recognized in international frameworks, i.e., Sendai Framework for disaster risk reduction (SFDRR) 2015–2030 [10].
At national level the NDMA may facilitate coordination among academia, research institutions, and private sector to undertake scientific and social research initiatives facilitating overall risk assessment of coastal areas of Pakistan on:
Earthquake and tsunami hazard analysis
Exposure data, vulnerability and capacity evaluations
Indigenous knowledge
Preparedness and response
Related policies, regulations, guidelines, bylaws, and codes
The Higher Education Commission (HEC), the National Institute of Oceanography (NIO), PMD, NDMA, PDMA Sindh, and PDMA Baluchistan should explore public-private partnership to encourage researchers to undertake the required studies mentioned in this section as well as ensure that the results are shared and available to the end user (including general public) and are incorporated in policies, regulations, and guidelines from national to local level.
International cooperation on tsunami warning and mitigation is envisaged to assure international compatibility and interoperability for rapid exchange of data and information. Pakistan is actively engaged in exchange of data and resources and capacity building initiatives through bilateral and global commitments. Pakistan is a member state of the Intergovernmental Oceanographic Commission of UNESCO (IOC-UNESCO), established in 1960 as a body with functional autonomy. The Pakistan Meteorological Department is the focal agency mandated to coordinate with UNESCO-IOC, ocean-wide tsunami warning providers for data sharing and capacity building regional and global initiatives.
The PMD in coordination with disaster management authorities at national and provincial level should ensure to participate in all capacity building initiatives and ocean-wide simulations and drills.
Effective participation in research, knowledge sharing, and capacity building should be ensured, and the PMD being the focal agency should play a lead role.
The PMD should also play a lead role in appropriate follow-up of global and regional collaborations from national to local level.
Coastal area residents in Baluchistan and Sindh provinces can experience a local earthquake—the most common cause of tsunamis—and a local tsunami generated in Arabian Sea can approach the coast within minutes.
Limited information regarding Pakistan coastline’s vulnerability is available to assess tsunami risk. Database is not appropriately maintained for social, physical (structural), economic, and environmental dimensions of exposure analysis, making the situation more critical. Since 2006 (in the after math of 2004 Indian Ocean Tsunami), some limited but focused efforts on tsunami hazard and risk assessment, mitigation, and preparedness have been piloted in the country since 2006 serious and consistent efforts of all stakeholders at policy and implementation level.
This chapter suggests earthquake and tsunami risk assessment and mitigation roadmap for Pakistan’s coastal areas with a vision of acquiring required deposit of information to plan and implement coherent and synergized earthquake and tsunami risk reduction measures. The guidelines for in various sections of the chapter are proposed for:
Determining the earthquake and subsequent local tsunami threat, in terms of hazard and risk assessment all along the coastline on a standardized pattern on priority basis, involving all levels of stakeholders.
Ensuing federal and provincial agencies utilize earthquake monitoring systems, tide gauges, deep ocean buoys, and other capabilities (international/regional information sharing systems to gather as much information as possible about a potential tsunami). Essential data is then used by forecasting and analysis centers for the assessment of the immediate tsunami threat. Timely and accurate warnings must then be disseminated in clear and actionable terms to emergency managers and a ready public.
Identifying mitigation strategies that involve sustained actions taken to reduce or eliminate the long-term risk to human life and property based on earthquake and tsunami risk assessments.
Aiming at tsunami-resilient communities that have plans, enhanced communications, and heightened awareness of the citizens to ensure resilience to earthquake and tsunami events, reduced economic losses, and shorten recovery periods.
Encouraging continued broad scientific and social research efforts needed to improve all-purpose understanding of tsunami processes and impacts and then to develop more efficient and effective risk assessment, risk communication, prediction and warning, preparedness, and mitigation measures.
Strengthening partnerships with international organizations and other countries persuade bilateral and multilateral agreements to better understand and reduce the common threat and impact of earthquake and tsunami in the region.
The term Green Chemistry refers to the strategies for the production and use of safer chemical products as replacements for hazardous substances. In this sense, hazardous substances can be defined in a broad way as any substance representing any physical, such as injury as a result of short or long term exposure; environmental, such as water or air pollution; or toxicological risks, such as mutations or cancer [1].
Although the search for safer reagents and solvents has been an ongoing process in modern chemistry, the term Green Chemistry was coined at the beginning of the 1990’s decade. Soon after the establishment of the Pollution Prevention Act of 1990 [2]. Among different proposals, this Act included source reduction as desirable in opposition to waste management in addition to pollution control and more cost-effective production and operation procedures to reduce or prevent pollution generated by industries.
In 1998, Anastas and Warner published the book Green Chemistry: Theory and Practice. This book presented for the first time the
The 12 Principles of Green Chemistry function like an instruction manual for those professionals willing to develop products and processes more aligned with the Green Chemistry concept. These Principles also have contributed to the popularization of Green Chemistry, since they work as a concise and accessible consulting resource. As the 12 Principles of Green Chemistry will be continuously recalled throughout this chapter, they are presented here to provide a quick reference to the readers [3].
Principle 1—Prevent the Waste.
Principle 2—Atom Economy.
Principle 3—Less Hazardous Chemical Synthesis.
Principle 4—Designing Safer Chemicals.
Principle 5—Safer Solvents and Auxiliaries.
Principle 6—Design for Energy Efficiency.
Principle 7—Use of Renewable Feedstocks.
Principle 8—Reduce Derivatives.
Principle 9—Catalyst reagents are preferred over stoichiometric ones.
Principle 10—Design for Degradation.
Principle 11—Real-time Analysis for Pollution Prevention.
Principle 12—Inherently Safer Chemicals for Accident Prevention.
Since the proposal of the Pollution Prevention Act, the Green Chemistry field has grown substantially in the scientific literature.
Many of the terms and parameters related to Green Chemistry were defined considering a molecular structure as a model to assess the safety and toxicological properties. While dealing with nanomaterials, besides molecular structure, other factors such as being crystalline or amorphous, crystal structure, surface area, particle size, porosity, and so on can play substantial roles regarding how a nanomaterial should be evaluated in relation to its production, life cycle, toxicity, and disposal. Hutchison
Concept | Molecular Context | Materials Context |
---|---|---|
Composition | Defined by molecular formula | Core and surface composition difficult to define; may vary according to sample shape and size |
Size/shape | Defined molecular structure and shape | Often a mixture of sizes and shapes, dependent on synthetic method |
Dispersity | Single and continuous composition and structure | Characterized by distributions of composition and structural features |
Purity | Purification procedure is intimately related to molecular structure (i.e. chromatography) | Small molecule impurities coming from surface coating or unreacted precursors significantly influence properties |
Toxicity | Possible to assess based on molecular structure | It may be inherent to the composition but also can be related to particle size, shape, or surface coating |
Comparison between molecular chemistry and materials chemistry context for different concepts.
Based on this context, this chapter focus on the strategies, perspectives, and advancements of the greener preparation of transition metal chalcogenides (TMCs). TMCs are part of a broad class of materials comprising binary, ternary, quaternary, and multinary sulfides, selenides, and tellurides. These materials have application in different areas such as solar cells, photocatalysis, sensors, photoinduced therapy, and fluorescent labeling [5, 6, 7]. Due to the technological importance of this class of material, it is necessary to find synthetic methods and sophisticated tools to help produce the TMCs nanomaterials through procedures aligned with Green Chemistry.
In this sense, we review the recent literature for the recent advances not only in the chemical synthesis of the TMCs, but also in emerging planning and analysis techniques, such as the design of experiments, life cycle assessment, and machine learning. These emerging techniques can contribute to the further advancement of Green Chemistry.
Any change in the synthetic process that eliminates or replaces a hazardous reagent or solvent [8], or is consistent with one of the 12 Principles of Green Chemistry will likely result in an overall process that is more environmentally friendly and less hazardous. Also, it is important to point out that the changes necessary to make the process greener must not compromise the quality of the final product. Green Chemistry, when successfully implemented, results in the green production of high-performance products. If performance is compromised, then the process does not yield a functional product.
There are many opportunities to make the synthesis of transition metal chalcogenides greener. In this section we outline strategies to
The selection of safer reagents and solvents that are unsuitable for producing high-quality materials represents a waste of time and resources. Thus, the best course of action is to first examine results from related work in order to reasonably predict whether a reaction or procedure will be successful using the greener precursors and solvents. Also, working at small scales in the initial stages can represent an economy of time and resources. If the procedure did not work well on a small scale, then one would not proceed to a larger scale procedure. Finally, careful examination of the safety materials associated with each chemical is crucial for preventing problems arising from the combination of incompatible materials or the production of toxic byproducts. These strategies specifically address Green Chemistry Principles 1, 5, and 12.
The wet-chemical synthesis of transition metal chalcogenides requires some source of energy input (to promote the diffusion process), which is often provided by heating the solution containing the starting materials to temperatures above 200°C. Often, this heating procedure is carried out using a reflux apparatus, which requires the consumption of many liters of water to cool the reflux column. Alternatives to refluxing include reactions assisted by microwaves or ultrasound [10]. Furthermore, procedures that enable the synthesis at lower temperature or even at room temperature represent a greener process. The use of more efficient energy input sources addresses Green Chemistry Principles number 1 and 6.
The reduction or elimination of byproducts can mean little to no post-synthesis purification is required. Indeed, the separation of the desired product from the reaction medium as well as from the undesired byproducts often represents the most waste-generating step. The reduction or elimination of byproducts addresses Green Chemistry Principles 1, 2, 6, and 8.
In the synthesis of transition metal chalcogenides, it is common to use capping agents, which are often surfactants, to obtain a certain size and anisotropic shape for the nanoparticles. In many cases, surfactants are necessary to obtain a particular anisotropic shape. However, in some cases, the growth can be controlled by the solvent, by varying the amount of a certain starting material, or adjusting other parameters like temperature, pH, or ionic strength. Avoiding unnecessary additives means less post-synthesis purification is required, and fewer reagents are required overall.
Nanoparticle synthesis methods commonly produce nanoparticles in some non-polar solvent. To use these nanoparticles for some applications often requires dispersion in a polar solvent. When this happens, it is necessary to replace the capping agent that makes the particle dispersible in the non-polar solvent with another capping agent that makes particle dispersible in a polar solvent. This ligand exchange procedure consumes time and additional solvent and reagents. In many cases, ligand exchange can be avoided by simply choosing a synthetic route that yields the nanoparticles with surface chemistry that is suitable for the final application. Avoiding unneeded additives and unnecessary ligand exchange steps directly address Principles number 2, 5, and 6.
Commonly employed purification procedures include washing nanoparticles with a solvent that can solubilize only the byproducts. Other purification processes are based on the difference in size of the products and byproducts, for instance, the size-exclusion chromatography and dialysis. All these procedures require the use of additional reagents, particularly solvents, which makes the purification procedure one of the most difficult steps to
An ideal synthetic procedure will produce the desired product in both high yield and high purity. Indeed, even trace impurities can drastically compromise the performance of devices. In order to reduce the total solvent required, in dialysis, for example, sequential dialysis against smaller volumes of pure solvent will generate less waste and a product with higher purity.
Judicious selection of solvent may also mean that the post-dialysis solvent could be recycled by passing through a purification column, for example. Alternative purification procedures should be investigated to select the method that will be the greenest possible without compromising the purity of the final product. The use of greener purification procedures addresses Green Chemistry Principles 3, 4, 7, and 12.
Design of Experiment (DoE) approach helps minimize the number of experiments. The experiment minimization agrees with the Green Chemistry Principles 1, 2, 6, 8, and 11. One way to efficiently decrease the number of experiments needed to fully analyze the data is to apply the concept of Design of Experiments (DoE). The DoE consists of a set of statistical techniques where the experiments are planned and performed according to a multivariate approach. The multivariate approach can be understood as an experimental plan where all the possible factors are varied simultaneously [11].
The multivariate approach contrasts with the univariate approach, which is generally known by the acronym OFAT, meaning one factor at a time. The OFAT approach is usually the standard approach in the chemical literature [12]. For instance, suppose that a research group is interested in studying the effect of temperature, pH, and concentration. And the goal of the research is to maximize the yield of the reaction.
According to the OFAT approach, the group would choose, for instance, five temperature levels, 4 pH values levels, and four concentration levels. And then, they would set a temperature and pH, and find an optimal concentration. Next, they will fix this optimal concentration and vary the temperature and pH in all levels, and find an optimal pH value. Then, finally, they will select the optimal concentration and pH, and vary the temperature in all five levels until finding the optimal temperature.
The OFAT approach, although widely used in the literature, has some drawbacks. The first one is the usual large number of experiments to be performed. The second one is that by fixing one level for all the variables, except the one that will be varied in all levels, can lead to a situation where not all possible experimental conditions were explored. Consequently, there is the chance that the most optimal condition determined is not the actual optimal condition. Another consequence of not varying all the variables at the same time is that all factors are not studied in a connected way [13]. Consequently, it is impossible to analyze the effect of the interaction among two or more factors. Ultimately, it hinders the obtaining of a mathematical model that would allow estimating the yield for conditions initially untested.
In contrast, in the multivariate approach for the same situation, only two levels would be selected for each factor (temperature, concentration, or pH). Then, all three factors are varied simultaneously, leading to a total of eight independent experiments. The results obtained for these eight experiments are analyzed according to a set of algorithms. The output of these calculations would allow estimating not only the effect of each factor independently. But also, the effect of all possible combinations of factors two by two, and the combination of the three factors. Then, after determining which factors and interactions have statistically significant effects, it is possible to refine the calculations and obtain an empirical model that would allow estimating the results for an experimental condition initially untested [14, 15].
This DoE explained in this example is called 2
The use of life cycle assessmentFollowing a system thinking approach Life Cycle Assessments (LCA) are designed to evaluate and assess the potential environmental, economic, and societal impacts related to the sourcing of reagents, processing, distribution, use, and disposal of materials [17, 18, 19]. By listing, mapping, and evaluating the safety and suitability of the material and energy inputs, products, and byproducts, it is possible to compare distinctive synthetic methods or different possible products by determining relevant metrics focusing on process intensity (similar to atom economy), toxicity, and cost [20, 21, 22, 23].
LCAs focused on metal nanoparticles have linked high energy consumption to upstream metal refining and been used to screen reducing agents indicating how these methods serve to analyze the literature and help tailor synthetic protocols [24, 25]. LCAs of manufactured photovoltaic cells with chalcogenides have been used to determine whether other components in these systems such as steel or glass contribute to downstream impacts helping to place research in a wider context [18].
While LCA methods are specific and tailored to a given system, examining analyses of metal chalcogenides and related green nanoparticle systems through metrics-based assessments can inform the design of transition metal chalcogenide nanoparticles and help mitigate unwanted impacts [22, 25, 26]. Researchers may look to blend their own experimental data with literature data to support claims of innovation or sustainability with quantitative analyses using a life cycle approach towards making and using nanoparticulate matter [27, 28, 29]. Life Cycle Assessment touches on many of the principles of green chemistry and specifically principles 1, 4, 6, and 10.
Data-driven approaches are found helpful in numerous fields of material science, especially when they are paired with computational methods [30, 31], where the data can be generated in a high-throughput fashion, with consistent quality. Data-driven methods are also beneficial to a traditional synthesis-oriented areas, especially due to digitalization of information (for example, lab notebook) processing the wealth of experimental notes becomes possible [32, 33]. The machine-learning applications in chemistry currently focus on property prediction (ranging from mechanical properties to electronic structure) [34, 35, 36] rather than structure prediction and exploratory synthesis guidance [37, 38, 39, 40, 41]. The areas of machine-learning application in materials science, include solar cells, perovskites, and non-centrosymmetric structures, which echoes with chalcogenides’ typical industrial applications.
Being one of the most rapidly emerging fields nowadays, machine learning quickly went through typical stages of method development and crystallized in the list of best practices for applying machine learning in materials domain [42]. For example, sharing entire code of the model, along with the input data and pre-processing methods, gave research publications transparency and promoted sharing the ideas to the next level. Democratization of data, approaches, and informatics allows domain experts to be part of the machine learning community, even with limited knowledge in computer science.
The main benefits of machine learning methods for materials are: (i) analysis of complex correlations between parameters and output,
Machine-learning approaches can guide us towards the direction of narrowing materials candidate pool, which eventually results in less waste (Principle 1). Targeted material selection minimizes the risk of exploring undesired composition, e.g. minimizing hazardous chemical content (Principle 3 and 5). Machine learning combined with DoE helps to optimize newly discovered material to improve their performance, which seconds the efficiency principle (Principle 6).
The correlation between each one of the strategies presented and the Green Chemistry Principles is shown in Figure 1.
Summary of the green chemistry principles correlated to each one of the strategies presented.
Transition metal chalcogenides (TMC) constitute an important class of materials and include different types of oxides, sulfides, selenides, and tellurides. Increasing interest has been devoted to TMC due to their technological applications in different fields such as photocatalysis, sensors, solar cells, supercapacitors, electrocatalysis, heterogeneous catalysis, and many other applications [43]. In view of the growing need and interest for this class of materials, it is necessary to find ways to produce them through solution chemistry synthetic routes that minimize the environmental impacts and health-related risks. In order to demonstrate that it is possible to produce TMC by greener routes, throughout this section, we will show some successful examples where changes in the synthetic process yielded substantial improvements by decreasing environmental impacts and biological risks.
Quantum Dot is a class of oxides, sulfides, selenides, and tellurides with a particle size smaller than the Bohr radius for that certain material. Consequently, quantum dots are subjected to a phenomenon called quantum confinement, where their absorption and emission on UV–visible range happens at higher energy as the particle size decreases [44, 45].
Initially, the synthesis of quantum dots was established by Bawendi and co-workers, in 1993 [46]. They were able to prepare monodisperse quantum dots of CdS, CdSe, and CdTe, with controlled crystallite size between 1.2 and 11.5 nm. Two slightly different methods were used to produce these cadmium chalcogenides quantum dots. Both methods were based on the hot-injection of the organometallic Cd, and S, Se, or Te sources in a hot trioctylphosphine oxide (TOPO).
In the first method, the source of Cd was dimethyl cadmium (Me2Cd), and elemental Se and Te. Me2Cd was dissolved in trioctylphosphine (TOP), Se, and Te were also mixed with TOP to form the organometallic compounds trioctylphosphine selenide (TOPSe) and trioctylphosphine telluride (TOPTe). The source of Cd, plus TOPSe or TOPTe were injected at TOPO around 200°C, and growth proceeded for temperatures between 230 and 260°C.
In the second method, the solvent (TOPO) and source of Cd (Me2Cd and TOP) were kept, but the sources of S, Se, and Te were replaced, respectively, by bis(trimethylsilyl) sulfide ((TMS)2S), Bis(trimethylsilyl)selenium ((TMS)2Se), and Bis(tert-butyldimethylsilyl)tellurium ((BDMS)2Te). The growth temperature was between 290 and 320°C for larger particles, and around 100°C, for particles having size around 1.2 nm.
Since the pioneer paper by Bawendi et al. [46], this hot-injection method using TOP/TOPO as solvent has been used for the synthesis of many binary chalcogenides (ZnS [47], ZnS doped by Mn [48], ZnSe [49], CdTe [50]). However, there are many opportunities to make this hot-injection synthesis more environmentally friendly and less harmful. One point for improvement is that the solvents TOP and TOPO are both considered to cause severe skin burns and eye damage [51, 52]. The Me2Cd is a flammable and pyrophoric compound that can ignite spontaneously if exposed to air, release flammable gases when in contact with water, and cause severe skin burns and eye damage, and respiratory irritation [53]. Additionally, Peng
Looking at Green Chemistry perspective, this CdO route also represents an accomplishment of the principles number 3, 4, 5, 8, and 12. Also, the fact that it was necessary to add, at least one more reagent (HPA or TDPA) does not represent a disagreement with principle 2, since neither HPA nor TDPA presents any known health hazard or toxicity issue [56, 57].
The Greenest solvent possible would probably be water, and theoretically, any pair of ions that can generate an insoluble product would be enough to produce a binary TMC. For instance, to produce CdS, it would be necessary just to find out some sources of Cd2+ and S2−, and mix them in water in concentrations that would exceed the CdS solubility product for a certain temperature and pH condition. Although this strategy may work for certain cases, it is very likely to generate products having a broad size distribution, heterogeneous composition, and without any shape control. To avoid these drawbacks, it is necessary to use some capping agent. A completely Green synthesis of CdS was described by Unni
The aqueous based or hydrothermal syntheses of selenides and tellurides are more difficult to be carried out in comparison to the sulfides one, since it is hard to find non-toxic and stable sources of selenium and tellurium. For instance, both Na2Se and Na2Te are toxic and very reactive to be controlled during the reaction [5, 59, 60]. Reduction of elemental Se or Te by sodium borohydride (NaBH4) in an oxygen-free atmosphere has been often used as a way to deliver Se2− and Te2− in aqueous synthesis [60, 61]. However, if this reduction does not happen completely, in case of selenides, amorphous elemental selenium can be generated, and it can crystallize to trigonal selenium, even at room temperature, in a range of few months [62].
Sodium selenite (Na2SeO3) or tellurite (Na2TeO3) have good solubility in water and can be easily purchased. However, as the oxidation state of Se and Te is +4, respectively, on Na2SeO3 and Na2TeO3, it is necessary to use an effective reducing agent because Se or Te will need to be first reduced to oxidation state 0, then further reduced to oxidation state −2. The most common reducing agent used in this case has been hydrazine (N2H4). The hydrothermal synthesis of selenides and tellurides from Na2SeO3 or Na2TeO3, using N2H4 has been successful preparing many compounds like: CdSe and CdTe nanorods [63, 64], ZnSe nanoflowers [65], ZnTe nanowires [66], NiSe nanoparticles [67], NiTe nanorods [68], among many other transition metal selenides and tellurides [68, 69, 70]. Although hydrazine is a versatile solvent enabling the dissolution of many different cations at room temperature [71], its high toxicity, flammability, pyrophoricity, and carcinogenicity make it a solvent hard to handle safely and therefore unsuitable for large scale applications [72].
Aiming to find new ways to deliver Se2− and Te2− to make the aqueous synthesis of selenides and tellurides, Xia
Binary chalcogenides often contain cadmium as the metal cation, which is a toxic and carcinogenic element for humans [79, 80] and an environmental concern regarding its segregation and disposal [81]. Additionally, binary chalcogenides usually have band-gaps higher than 2.5 eV, which is suitable for the absorption of the UV radiation of the electromagnetic spectra, whereas ternary and quaternary chalcogenides typically have band-gaps ranging from 0.5 to 2.0 eV, which is suitable for the absorption of the visible light. Among different types of ternary and quaternary chalcogenides, we will focus our attention to a class of quaternary chalcogenide represented by the formula Cu2ZnSnS4, which will be hereafter referred to as CZTS. CZTS is comprised of non-toxic and earth-abundant elements, features that align with Green Chemistry Principles. In addition, its direct band-gap around 1.5 eV and high-absorption coefficient (> 104 cm−1) make CZTS a suitable material for many applications, including use as the absorber layer in thin film solar cells [82], counter-electrode material in dye sensitized solar cells [83], visible-light photocatalyst for water pollutant degradation [84], as well as use in heterostructures with Pt or Au for H2 evolution in water splitting systems [85].
Generally speaking, the successful hydrothermal synthesis of CZTS requires relatively long reaction times (ca. 12–24 h). To speed up the reaction and reduce the overall energy required, microwave heating represents a promising alternative to conventional heating. An important consideration is the capacity of a given solvent to absorb microwaves, which is measured by a parameter called dielectric loss factor (tan δ). In general, tan δ can be classified as high (tan δ >0.5), medium (0.1 < tan δ < 0.5), and low (tan δ <0.1) [86]. Water has a tan δ of 0.123, which is on the very low side of the medium range. Ethylene glycol, which does not have any toxicity if not ingested [87], has a high tan δ of 1.350 [86], which has led to its use for the solvothermal synthesis of CZTS using microwave heating.
Pinto
In both papers by Pinto
Table 2 summarizes the main papers presenting some advance towards the Green Chemistry application to the solution-based synthesis of transition metal chalcogenides nanoparticles.
Material | Size and morphology | Reactants | Method and Temperature | Reference |
---|---|---|---|---|
CdS | Quantum confined nanoparticles and nanorods | CdO, HPA, TDPA, TOPO, and S | Hot-injection at 300°C | [55] |
CdSe | Quantum confined nanoparticles and nanorods | CdO, HPA, TDPA, TOPO, and Se | Hot-injection at 300°C | [55] |
CdTe | Quantum confined nanoparticles and nanorods | CdO, HPA, TDPA, TOPO, and Te | Hot-injection at 300°C | [55] |
CdS | Quantum confined nanoparticles between 3 and 5 nm | CdSO4, Na2S2O3, water, thioglycerol | Co-precipitation at 30°C | [58] |
CdS:Zn+2 | Quantum confined nanoparticles between 3 and 5 nm | CdSO4, Na2S2O3, water, ZnSO4, thioglycerol | Co-precipitation at 30°C | [58] |
CdS:Cu+2 | Quantum confined nanoparticles between 3 and 5 nm | CdSO4, Na2S2O3, water, CuSO4, thioglycerol | Co-precipitation at 30°C | [58] |
CdTe/CdSe | Core-shell quantum dots | CdCl2, MPA, NaHTe, Na2SeSO3, water, | Reflux at 100°C to prepare the core CdTe, and around 78°C to prepare the shell CdSe | [73] |
Cu2ZnSnS4 (CZTS) | Agglomerated particles around 20 nm | Copper (I) acetate, Copper (II) acetate, zinc acetate, tin (II) acetate, tin (IV) acetate, Ethylene glycol, thiourea, L-cysteine, thioglycolic acid, MPA | Microwave heating at 160°C | [88] |
Cobalt-doped Cu2ZnSnS4 | Agglomerated particles around 20 nm | Copper (II) acetate, zinc acetate, tin (II) acetate, cobalt (II), ethylene glycol, thiourea, sodium thioglycolate | Microwave heating at 160°C | [89] |
Papers presenting some advance towards the green chemistry application to the solution-based synthesis of transition metal chalcogenides nanoparticles.
Generally speaking, the chemical synthesis of nanoparticles may involve the use of dangerous and non-biocompatible chemicals. This fact has created a demand for a greener approach to nanoparticles through biological synthesis.
Although the biological approach to quantum dots (QD) synthesis shows extreme promise with attributes such as control over the size and shape of the nanoparticles and biocompatibility, opening a market for the medical use of nanoparticles and TMCs. The promise of biologically synthesized nanoparticles fits right with the theme of
The biological approach typically uses cells within plants or fungi by surrounding the cells with a metal-ion solution that triggers a cell’s defense mechanism. These specific cells can be engineered biologically to produce different shaped QDs and TMCs.
Bacterial, microbial, and viral methods offer a promising future for QDs and TMC-nanoparticles in terms of ‘going greener’. The sheer variety of microorganisms provides a wide range of biological attributes from the natural selection from millions of years. As a result, these microorganisms are incredibly efficient at excreting the required enzymes to synthesize QDs and TMC-NPs both intra and extracellularly [90].
This synthesis method also generally occurs in relatively tame environments, bypassing the high heat and pressure usually associated with chemical synthesis. CdSe QDs, for example, typically require temperatures in the range of 240–300°C when chemically synthesized [91]. When performed biologically, the synthesis will occur close to room temperature, requiring less input work and falling right in line with Green Chemistry principles 6 and 12.
CdS QDs are other examples of a TMC that has high temperature and hazardous chemicals associated with it. A massive step forward in improving this process was the discovery of a genetically engineered strain of
Despite the additional steps necessary to obtain the CdS quantum dots, the intracellular preparation has proven to be capable of generating functional CdS quantum dots. For example, Yan and coworkers produced intracellularly from
On the other hand, many other forms of bacteria have been shown to excrete enzymes and synthesize QDs and nanocrystals extracellularly.
In general terms, control over the nanoparticles size and shape is also seen as a drawback in regard to bacteria and microbes because of the many variables to be controlled in the synthesis. That being said, differences in pH, metal-salt solution concentration, and temperature may all play a key role in dictating the size and shape of the nanoparticles. These conditions have also been found to dictate whether the synthesis occurs intra or extracellularly, both responding to different factors.
Few known species can reliably create specifically shaped nanostructures. For instance,
The variety of bacteria available in the environment and described in the literature could help us take advantage of the biomineralization processes similar to the ones demonstrated by
Fungi are part of another important category of microorganisms that can be used in the preparation of chalcogenide nanoparticles. For instance, Tudu and coworkers prepared spherical CdS QDs using the
The rot fungus
Table 3 summarizes the main papers some advance towards the Green Chemistry application of biological structures to the synthesis of transition metal chalcogenides nanoparticles.
Material | Size and morphology | Microorganism | Method and Temperature | Reference |
---|---|---|---|---|
CdS | Nanoparticles around 8 nm | Intracellular | [92] | |
CdS | Nanoparticles around 10 nm | Intracellular. | [93] | |
CdS | Particles ranging from 5 to 200 nm | Extracellular. Biotransformation of Cd+2 ions into | [94] | |
PbS | Hollow nanostructures and hollow nanotubes | Pb+2 ions and thioacetamide were dispersed in the microorganism suspension and sonicated at room temperature for 6 h | [95] | |
ZnS | Hollow nanostructures and hollow nanotubes | Zn+2 ions and thioacetamide were dispersed in the microorganism suspension and sonicated at room temperature for 6 h | [95] | |
CdS | Nanoparticles in the 3 to 5 nm range | Cd+2, microorganism extract, and Na2S were added in aqueous solution and heated at 60–80°C for 16 in the dark | [96] | |
CdS | Nanoparticles with size below 10 nm | Cd+2, MPA, thioacetamide, and the microorganisms were added to water, pH adjusted to 10. The mixture was incubated at 28°C for 24 h | [97] |
Papers presenting some advances towards the green chemistry application of biological organisms and structures for the synthesis of transition metal chalcogenides nanoparticles.
Mechanochemistry is the result of chemical transformations from grinding, milling, and similar changes in mechanical force, and this technique is often conducted without solvents [98].
Mechanochemistry has been more recently revived in part because of its alignment with the principles of
Mechanochemical syntheses with chalcogenides typically follow one of two routes in either a dry or wet mode [106]. In a dry reaction mode, metal and chalcogenide are milled together, while in wet systems, salts including acetates and sodium sulfide are used [107]. After completion, the reaction mixture is washed, and the sodium acetate or other salts are removed before drying. The reduction or elimination of solvent can have a cascade of impacts by increasing reaction efficiency and reducing costs related to waste disposal and treatment [108].
Mechanochemical methods have been leveraged to synthesize binary and complex metal sulfides and other chalcogenide nanoparticles [106, 109]. By controlling the mechanical energy of a system, chemists and engineers can tailor chemical and structural changes, polymorphic structures, and the materials resulting properties [101, 110, 111]. Short milling times on the order of seconds have yielded Cu3Se2 from copper selenide blends at room temperature [112].
Liquid-assisted milling systems have been demonstrated to run at low temperatures reducing energy consumption compared to reactions run at high temperatures [113]. Sonochemical methods represent different ways to promote and control reactions using sound energy in solutions where intense local heating and pressure events occur with short lifetimes [114, 115, 116]. These methods may be expanded to address how catalysts are used in fixed bed reactors in industry [117, 118].
The synthesis and use of metal chalcogenides present a green chemistry challenge from both the process safety and the environmental toxicology perspectives [119, 120]. Mechanochemical methods have been used to study the use of inert additives to synthesize copper sulfides in a non-explosive regime. This method allowed to control the obtained polymorph as covellite (CuS) or chalcocite (Cu2S) [121].
Ohtani
It is essential to highlight the additional use of complementary methods used alongside mechanochemical techniques such as thermal and microwave setups or electrical discharge milling (EDAMM) [106, 123]. All of these serve to extend the range and scope of transition metal chalcogenides and their engineered nanostructures possible to be obtained. Thus, providing accessible methods that spawn compelling functional products such as superconductive InXNb3Te4 [109].
In situ monitoring of mechanochemical reactions may improve methods for the real-time detections of polymorphs, products, and potential toxins, in line with the 12th principle of green chemistry. For more comprehensive information about the mechanochemistry scope on preparing TMCs, readers are welcome to check the review article by Baláž
The DoE can be applied in many situations involving TMCs preparation and performance. For instance, Ribeiro
However, in addition to these features, a 23 full factorial design followed by a central composite design (CCD) was carried out for each capping agent, which corresponds to eighteen experiments with four replicates in the center point. Three capping agents were studied, they were: 3-mercaptopropionic acid, L-glutathione, and 2-mercaptoethanesulfonate. The factors studied were the mole ratio between Cd2+ and Te2−, the mole ratio between Cd2+ and the capping agent, and the pH. The factorial design allowed them to obtain a quadratic model for the set of experiments for each one of the capping agents. Interestingly, the statistically significant terms vary according to the capping agent used. The response surface graphs obtained for each model revealed that the QY was maximized when the L-glutathione was used as the capping agent, in the following conditions: pH of 9.8, Cd2+/Te2− mole ratio of 1:0.2, and Cd2+/glutathione mole ratio of 1:0.77.
Copper antimony sulfides (Cu
Another promising alternative to the binary Cd or Pb-containing semiconductor quantum dots is the ternary semiconductor AgInS2. The AgInS2 has photoluminescence QY higher than 50%, all over the visible and near infrared range of the electromagnetic spectrum, when passivated with a ZnS shell [128]. With the goal to prepare AgInS2 based semiconductor quantum dots, Soares
Due to the large number of factors studied, the authors had to initially perform a fractional factorial design of the 25–1 type, which initially corresponded to 16 independent experiments. This initial design revealed that the significant factors were Ag:In ratio, MPA:In ratio, and the solution pH. Then, a 23 factorial design with central composite design was performed considering only the optimization of the three significant factors. The highest QY, which was around 0.46, was obtained for Ag:In equal to 0.1, pH 8.5, MPA:In equal 6. Besides the QY = 0.46, this set of conditions had an emission wavelength maximum at 625 nm, a lifetime emission of 400 ns, a Ag:In:Zn proportion about 1:3:5.
The application of semiconductor nanocrystals in solar cell devices requires the deposition of continuous thin films from the semiconductor materials. To obtain an appropriate thin film demands the optimization of several factors. In this sense, Ramírez
The examples presented in this section showed how the DoE could be used to decrease the number of experiments performed vastly in different contexts and stages of production of the TMCs semiconductor nanoparticles and thin films. Furthermore, the DoE provides statistical justification for each decision taken and for the empirical models developed, which can not be obtained through the OFAT approach.
As commented in Strategy 7 in Section 2.7, life cycle assessments (LCA) can contribute to developing a greener process by analyzing the resources and energy input, the cost-effectiveness, and the social and economic impacts involved in that specific process.
To illustrate the utility of life cycle assessments, a simplified LCA was performed by aggregating and reframing data from several different routes to distinctive copper sulfide nanosystems [22, 25]. Five different synthetic protocols were selected from the literature and with open-access resources these data are used to calculate metrics related to economic, societal, and environmental impacts associated to the chemicals and relative amounts in the protocols [131, 132, 133, 134, 135].
The selected synthetic protocols for copper sulfides share similarities. Most use different amounts of dodecanethiol as a source of sulfur and capping agent, along with solvents such as ethanol and chloroform for workup [131, 132, 133, 134, 135]. Despite common reagents, the methods and routes vary across the protocols allowing for access to downstream heterostructured nanoparticles [131], generalized procedures (towards an array of TMCs nanosystems) [132], a one-step synthesis and assembly [133], control over product shape [134], and solventless techniques [135]. These pieces of information from these five protocols were extracted from the literature and using physicochemical reference data [136, 137], SDS, and online databases [138]. The above metrics were calculated for the different sets of methods (Table 4).
Life Cycle Assessment of Copper Sulfide Nanosynthesis | ||||||
---|---|---|---|---|---|---|
Procedure | Process Mass Intensity | Material Cost | Global Warming Potential | Smog Formation Potential | Ingestion Toxicity | Product |
1 | 1.0 | 1.0 | — | 1.3 | 8.7 | Cu2S Hexagonal Nanoplatelets |
2 | 9.3 | 1.9 | — | 4.9 | 50 | Cu9S5 Digenite phase Nanowire Aggregates |
3 | 5.9 | 33 | 3.7 | 3.7 | 8.1 | Cu2S Tunable Nanoparticles |
4 | 1.3 | 8.4 | 1.0 | 1.0 | 1.2 | Cu2S 2D-Nanosheets |
5 | 6.8 | 49 | 6.0 | — | 1.0 | Cu2S Hexagonal Nanoplatelets |
Life cycle assessment of copper sulfide nanosystems. Metrics are normalized by column such that the least impact and most benign has a value of 1.
For this analysis, five metrics were selected to demonstrate the flexibility of this technique: process mass intensity, material cost, global warming potential, smog formation potential, and ingestion toxicity (Figure 2) [139, 140, 141]. While LCAs typically focus on environmental and energy impacts they may be broadened or adapted to address a variety of economic and societal impacts as with techno-economic assessments which have been performed for evaluating downstream copper recovery from spent electronics [20, 142, 143, 144]. An additional metric not used here which is relevant when screening metals with TMCs is the abiotic depletion potential, which examines the impacts of elemental scarcity in products including inorganic materials [26].
Metrics used to assess the synthesis of copper sulfide nanosystems and the information used to calculate these metrics.
Process mass intensity (PMI) is a ratio of the masses of the chemical inputs for a process over the products [139]. Similar to E-Factor and related to atom economy, process mass intensity accounts for byproducts and wastes, including solvents [145]. This may serve to help identify materially efficient transformations contributing to the prevention of waste [146]. Cost is determined as a sum of the scaled costs of each reagent used to synthesize 1 gram of product and does not include operational costs related to energy, nor capital costs for equipment, which are the focus of other LCAs [23, 27].
The final three metrics are related to human and environmental health. They are calculated using available potentials and safety data related to the specific impact of a given chemical in a procedure to a reference chemical such as toluene [141, 145, 147]. The potential for each chemical is multiplied by the relative mass per product and the sum of each potential generates an impact index. The relative magnitude of these indices identifies the expected impact of the procedure on a model environment [145]. Global warming potential (GWP) accounts for the incorporation of greenhouse gases, such as carbon dioxide, chloro- and hydrochlorofluorocarbons [17, 26]. Smog formation potential (SFP) assesses a variety of volatile organic chemicals such as ethanol and acetone, that can partake in reactions with pollutant oxidants at ground level [147, 148]. Ingestion toxicity (ING) models how chemicals may disperse in an external environment and their relative potential to harm living systems [21, 119].
Collecting these metrics, we can get a more holistic perspective of how a specific synthesis procedure can have both up- and down-stream impacts (Table 4). Here no one metric is any more important than another, and we quickly realize that there is no one best protocol. This allows us to look back at our work and examine why a specific value is high or low and why and how another procedure has a better or worse value and perhaps adopt a chemical or method from this protocol.
Templates and other resources for this type of LCA are available online with the full set of calculations available of this LCA in the supplementary information [23, 147, 149]. The reader should note the assumptions that accompany this analysis: primarily using a multi-compartmental model to represent an external environment, the standard estimation of amounts for techniques such as washing and filtering, and neglecting to consider the cost of water [141]. The functional unit for this assessment represents a way to standardize the analysis across the procedures for differently scaled references and here was set as 1 gram of product. After calculations are performed the data is normalized per metric such that the most benign or least impactful value is scaled to one.
Assessing a synthesis or comparing several goes beyond setting any one metric. Here one may make the distinction between the cost effective and efficient methods in the first procedure and the more costly, yes less environmentally impactful methods in the fourth protocol. Examining protocol one’s high ingestion toxicity parameter we can look back at the calculation to reveal it stems from a large excess of dodecanethiol. As this serves as solvent, a source of sulfur, and a capping agent, one may deem it a necessary hazard though they may also explore in the future how to better balance the stoichiometry of reagents.
Interestingly the solvent-free synthesis, method five, has a high process mass intensity and cost due to solvents such as chloroform that are used in the workup. LCA methods may be used to better model whether a system is greener than alternative methods by leveraging common and novel sustainability metrics [139, 140].
In contrast to the narrow focus on synthesis in the above example, LCAs ideally have a wide scope, including a look at sourcing reagents all the way to recovery or disposal [150]. A fundamental goal of green chemistry and systems thinking is the use of loops to close gaps between wastes and resources. LCAs may be used to address these considerations [151].
Although their power and flexibility LCAs are limited by the quality and accessibility of their source data. Even rudimentary assessments may prove inconclusive for certain values and metrics, note in Table 4 for dashed entries without a calculated value. Empty values in an LCA may indicate a lack of literature information or imperfect metric, which also provides researchers with a focus on what information is missing from the literature. As LCAs are inherently complex many choose to use proprietary software such as GaBi or ASPEN though researchers must be careful to avoid using LCAs as a black box. To help steer and assess the synthesis, application, scale-up, and recycling of transition metal chalcogenides life cycle assessments can be used to systematically evaluate procedures for green chemists and engineers.
Proposing new materials requires extensive sustainability, availability, and economic metrics analysis. While reports of individual compounds focus on specific composition metrics, typically considering economic factors. Only within the most recent years, in the extensive review work, it is important to compare the proposed class of compounds (chalcogenides in our case) with other classes, taking into account trends in economics.
In this section, we look at machine learning applied to the chalcogenide materials from three main aspects: First, we present a study showing how machine learning was used to catalog the band gap diversity among materials containing p-block elements. Second, we present and examples from the recent literature where machine learning was applied to predict properties and trends related to TMCs.
To estimate the fraction of chalcogenide materials among all compounds with report or calculated band gap or absence of the band gap, 6031 reports were analyzed. The band gap values obtained experimentally were summarized in the literature reports [152, 153, 154, 155]. For the compounds without band gaps, the data was extracted from the Materials Project database [156]. For this work, only a fraction of unique reports were used, and the full dataset is listed in the supporting information of the manuscript by Zhou
Absolute number of reports of materials with band gap and with metallic character.
A detailed analysis of the band gap reports for the Group VI elements, revealed that the element are distributed as the following: O—1014, S—1416, Se—1081, Te—614. Interestingly, the reported band gap value follows the trend of shifting the distribution of band gaps from insulating to metallic character for the elements of the Group VI, when going from lower principal quantum number to higher, similarly to the periodic table property change from non-metals to metals (Figure 4).
Band gap energy distribution for different oxides, sulfides, selenides, and telurides.
This is the most diverse distribution of the band gaps among all other p-block elements, allowing a band gap engineering for tailoring materials for a specific application need. From the average of 3.5 eV for oxygen 2.0 eV for S, 1.8 eV for Se, and 0.6 eV for Te, chalcogenide materials are the most suitable candidates for semiconductor synthesis and study.
The number of experimentally-confirmed predictions in the field of machine learning chemistry is limited [158]. Commonly, physics-based simulations (molecular dynamics or density functional theory) are regarded as experimental validation of a machine-learning model [159]. Developing a functional informatics infrastructure with training data pipeline, selection of appropriate algorithm, and assessment of model performance, requires expertise in both domain knowledge and informatics. This synergy is what converts model’s prediction to a real sample of a lab bench.
Combination for ML and DoE makes exploration of optimal synthesis conditions, faster and more efficient. For example, organic solar cell efficiency was increased substantially, increasing the efficiency of solar energy conversion from 6–8%, confirmed with a real working device [160]. Given that solar cell is also an area where chalcogenides are viewed as promising candidates, we can expect similar performance boost with application of machine learning methods [161].
Band gap prediction (fundamental for semiconductor, lighting, sensor, and solar cell areas) is one of the most common property prediction that was tackled with machine-learning methods [157, 162]. Chalcogenides, especially the binary ones with ZnS-type structure, are promising candidates. Transition metals (most common components in binary ZnS-type chalcogenides) are prone to statistical mixing, which allows for a precise control of the band structure in these materials [163]. Ternary chalcogenides were predicted to be promising p-type transparent conductors [162]. The compositional diversity of the chalcogenide-rich candidates is represented by two transition metal elements present (VCu3S4), or TM with p-block element (IrSbS), or alkaline-earth with metalloid (Ba2SiSe4). Double perovskites of chalcogenides are promising photovoltaics. The formation of perovskites is governed by strict structural geometrical rules along and charge-balanced composition. This puts limitation on the list of possible candidates, however, given that for double perovskites quaternary systems have to be explored, machine learning is essential, since the unexplored chemical white space in quaternary phase diagrams is impossible to explore experimentally [164].
This chapter presented many views and examples of how Green Chemistry can be used to benefit TMCs in different scientific fields. These benefits can be explored in many different stages of the TMCs planning and production. For instance, there are different approaches to make TMCs syntetic processes greener, such as using more benign reagents and solvents, milder synthetic conditions. Or using biological media or solventless methods like mechanochemistry.
Additionally, DoE can be used to plan more efficiently the number of experiments necessary to draw certain conclusions and obtain models allowing to predict initially untested synthetic conditions. LCA can be used to predict the risks, benefits, and environmental impacts involved in the production, use, and disposal of TMCs. Machine Learning is important in predicting TMCs properties, which offers useful guidelines for the synthesis of known TMCs. It is also valuable for predicting the structural features and properties of the materials never synthesized, opening up possibilities for discovering new TMCs.
We hope this chapter can be a resource for scientists aiming to make their nanoparticle synthetic processes more benign and environmentally friendly.
The authors would like to thank Manhattan College Department of Chemistry & Biochemistry and Manhattan College School of Science for their support.
The authors declare no conflict of interest.
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The existence of relationships between environmental changes and health in humans and animal species is well known and it has become generally accepted that poor health affects the animal’s natural behaviors and animal welfare and, consequently, food safety and animal production quality. Microclimate alterations, husbandry-management conditions, quality of human-animal interactions, feeding systems, and rearing environment represent the main factors that could negatively affect animal welfare and may produce behavioral, biochemical, endocrine, and pathological modifications in domestic and wild animals. Particularly, high stress levels can reduce the immune system response and promote infectious diseases. Adverse socio-environmental factors can represent a major stimulus to the development of different pathologies. 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During March 2017, the Food and Agricultural Organization of the UN through its ‘Rome Declaration’ called for the urgent need to combat RPW by collaborative efforts and commitments at the country, regional and global levels to stop the spread of this devastating pest. There exist gaps and challenges in almost all the components of the current RPW-IPM strategy, particularly with regard to early detection, developing and implementing phytosanitary measures, lack of effective biological control agents in the field and poor farmer participation in the control programmes, which have made RPW control and eradication extremely difficult. This chapter gives an overview of the global invasion, current management options, challenges and future prospects for its effective control.",book:{id:"9698",slug:"invasive-species-introduction-pathways-economic-impact-and-possible-management-options",title:"Invasive Species",fullTitle:"Invasive Species - Introduction Pathways, Economic Impact, and Possible Management Options"},signatures:"Hamadttu Abdel Farag El-Shafie and Jose Romeno Faleiro",authors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"El-Shafie",slug:"hamadttu-el-shafie",fullName:"Hamadttu El-Shafie"},{id:"320867",title:"Dr.",name:"Jose",middleName:null,surname:"Romeno Faleiro",slug:"jose-romeno-faleiro",fullName:"Jose Romeno Faleiro"}]},{id:"72961",title:"Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae): An Invasive Insect Pest Threatening the World Tomato Production",slug:"-em-tuta-absoluta-em-meyrick-lepidoptera-gelechiidae-an-invasive-insect-pest-threatening-the-world-t",totalDownloads:618,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"The South American tomato pinworm or tomato leaf miner (TLM), Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae), is a serious invasive and destructive insect pest of tomato (Solanum lycopersicum L.) worldwide. The moth can cause 100% damage in tomato crop in both greenhouses and open fields if control measures are not carried out. Due to the high reproduction potential, dispersal ability, and tolerance to environmental conditions, the TLM invaded most tomato-producing countries in Europe, Africa, and Asia. The tomato leaf miner originated in South America and was first introduced in Spain in 2006 and from where it spread to other part of the world. This chapter consolidates the rich literature on the pest with emphasis on invasion history, economic significance, and possible management options adopted worldwide.",book:{id:"9698",slug:"invasive-species-introduction-pathways-economic-impact-and-possible-management-options",title:"Invasive Species",fullTitle:"Invasive Species - Introduction Pathways, Economic Impact, and Possible Management Options"},signatures:"Hamadttu Abdel Farag El-Shafie",authors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"El-Shafie",slug:"hamadttu-el-shafie",fullName:"Hamadttu El-Shafie"}]},{id:"72034",title:"Invasive Insects in India",slug:"invasive-insects-in-india",totalDownloads:898,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Invasive alien species (IAS) is an exotic species that becomes established in natural or seminatural ecosystems or habitats. It is an agent of change and threatens native biological diversity. Invasive insects in India have been a major threat to household commodities, human health, agricultural produce and environment. India is highly diversified in its weather and climate, which supports the establishment of various introduced insects from other parts of the world. Furthermore, globalisation has facilitated numerous introductions of invasive insect pests. There have been 23 invasive alien insects reported from India to date. This chapter exclusively deals with the characteristics of insects that make them invasive, the common pathways of entry of the invasive insects, the steps through which the introduced insect has established itself in the foreign land and finally the ways to manage them.",book:{id:"9698",slug:"invasive-species-introduction-pathways-economic-impact-and-possible-management-options",title:"Invasive Species",fullTitle:"Invasive Species - Introduction Pathways, Economic Impact, and Possible Management Options"},signatures:"Swoyam Singh, Jai Hind Sharma, Avinash Udikeri and Hashib Ansari",authors:[{id:"315507",title:"Dr.",name:"Swoyam",middleName:null,surname:"Singh",slug:"swoyam-singh",fullName:"Swoyam Singh"},{id:"317139",title:"MSc.",name:"Hashib",middleName:null,surname:"Ansari",slug:"hashib-ansari",fullName:"Hashib Ansari"},{id:"318716",title:"Mr.",name:"Jai Hind",middleName:null,surname:"Sharma",slug:"jai-hind-sharma",fullName:"Jai Hind Sharma"},{id:"318717",title:"Mr.",name:"Avinash",middleName:null,surname:"Udiker",slug:"avinash-udiker",fullName:"Avinash Udiker"}]},{id:"25356",title:"Increase in Anoxia in Lake Victoria and Its Effects on the Fishery",slug:"increase-in-anoxia-in-lake-victoria-and-its-effects-on-the-fishery",totalDownloads:3130,totalCrossrefCites:9,totalDimensionsCites:18,abstract:null,book:{id:"1051",slug:"anoxia",title:"Anoxia",fullTitle:"Anoxia"},signatures:"Murithi Njiru, Chrisphine Nyamweya, John Gichuki, Rose Mugidde, Oliva Mkumbo and Frans Witte",authors:[{id:"70254",title:"Dr.",name:"James",middleName:"Murithi",surname:"Njiru",slug:"james-njiru",fullName:"James Njiru"}]}],onlineFirstChaptersFilter:{topicId:"330",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:290,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). 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Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. 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His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,annualVolume:11421,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. 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His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. 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This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. 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Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. 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It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. 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The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems.
\r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
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