Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
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This achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
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We are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
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Thank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
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\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1485",leadTitle:null,fullTitle:"Applications of Monte Carlo Method in Science and Engineering",title:"Applications of Monte Carlo Method in Science and Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"In this book, Applications of Monte Carlo Method in Science and Engineering, we further expose the broad range of applications of Monte Carlo simulation in the fields of Quantum Physics, Statistical Physics, Reliability, Medical Physics, Polycrystalline Materials, Ising Model, Chemistry, Agriculture, Food Processing, X-ray Imaging, Electron Dynamics in Doped Semiconductors, Metallurgy, Remote Sensing and much more diverse topics. The book chapters included in this volume clearly reflect the current scientific importance of Monte Carlo techniques in various fields of research.",isbn:null,printIsbn:"978-953-307-691-1",pdfIsbn:"978-953-51-5604-8",doi:"10.5772/1954",price:169,priceEur:185,priceUsd:219,slug:"applications-of-monte-carlo-method-in-science-and-engineering",numberOfPages:966,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"08abe20f1549c83cfb208c83e12ee7df",bookSignature:"Shaul Mordechai",publishedDate:"February 28th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/1485.jpg",numberOfDownloads:122701,numberOfWosCitations:130,numberOfCrossrefCitations:32,numberOfCrossrefCitationsByBook:17,numberOfDimensionsCitations:85,numberOfDimensionsCitationsByBook:26,hasAltmetrics:1,numberOfTotalCitations:247,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 25th 2010",dateEndSecondStepPublish:"June 22nd 2010",dateEndThirdStepPublish:"October 27th 2010",dateEndFourthStepPublish:"November 26th 2010",dateEndFifthStepPublish:"January 25th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"21994",title:"Prof.",name:"Shaul",middleName:null,surname:"Mordechai",slug:"shaul-mordechai",fullName:"Shaul Mordechai",profilePictureURL:"https://mts.intechopen.com/storage/users/21994/images/1585_n.jpg",biography:"Dr. Shaul Mordechai (PhD) is a Professor of Physics and Head of the Biomedical Spectroscopy Laboratory at the Department of Physics, Ben Gurion University, Israel. He received his PhD from the Racah Institute of Physics, Hebrew University Jerusalem. His research interest include: Medical Physics, Biomedical Optics, FTIR-Microscopy, FTIR-Imaging, Mid-IR Spectrometry, Fluorescence Spectroscopy, Optical Diagnostics, and Biomedical Applications of Monte Carlo Simulations. He was a Visiting Scientist at the University of Texas at Austin, Los Alamos National Laboratory and the University of Pennsylvania. He is a Member of the Editorial Board of World Journal of Biological Chemistry (WJBC), Associate Editor - Medical Physics, Fellow of the American Society for Laser Medicine and Surgery. He has coauthored many papers in Biomedical Optics, Tissue Microscopy, Optical Diagnostics and Applications of Monte Carlo Simulations in Biomedical Optics.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"599",title:"Computer Simulation",slug:"numerical-analysis-and-scientific-computing-computer-simulation"}],chapters:[{id:"14004",title:"Monte Carlo Simulations in NDT",doi:"10.5772/15295",slug:"monte-carlo-simulations-in-ndt",totalDownloads:4619,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Frank Sukowski and Norman Uhlmann",downloadPdfUrl:"/chapter/pdf-download/14004",previewPdfUrl:"/chapter/pdf-preview/14004",authors:[{id:"20239",title:"Dr.",name:"Frank",surname:"Sukowski",slug:"frank-sukowski",fullName:"Frank Sukowski"},{id:"21967",title:"Dr.",name:"Norman",surname:"Uhlmann",slug:"norman-uhlmann",fullName:"Norman Uhlmann"}],corrections:null},{id:"14005",title:"Application of Monte Carlo Simulation in Optical Tweezers",doi:"10.5772/14542",slug:"application-of-monte-carlo-simulation-in-optical-tweezers",totalDownloads:2673,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Yu-Xuan Ren, Jian-Guang Wu and Yin-Mei Li",downloadPdfUrl:"/chapter/pdf-download/14005",previewPdfUrl:"/chapter/pdf-preview/14005",authors:[{id:"18108",title:"Dr.",name:"Yu-Xuan",surname:"Ren",slug:"yu-xuan-ren",fullName:"Yu-Xuan Ren"},{id:"18109",title:"Dr.",name:"Jian-Guang",surname:"Wu",slug:"jian-guang-wu",fullName:"Jian-Guang Wu"},{id:"18110",title:"Dr.",name:"Yin-Mei",surname:"Li",slug:"yin-mei-li",fullName:"Yin-Mei Li"}],corrections:null},{id:"14006",title:"Enabling Grids for GATE Monte-Carlo Radiation Therapy Simulations with the GATE-Lab",doi:"10.5772/15904",slug:"enabling-grids-for-gate-monte-carlo-radiation-therapy-simulations-with-the-gate-lab",totalDownloads:2185,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Sorina Camarasu-Pop, Tristan Glatard, Hugues Benoit-Cattin and David Sarrut",downloadPdfUrl:"/chapter/pdf-download/14006",previewPdfUrl:"/chapter/pdf-preview/14006",authors:[{id:"22422",title:"Dr.",name:"Sorina",surname:"Camarasu-Pop",slug:"sorina-camarasu-pop",fullName:"Sorina Camarasu-Pop"},{id:"22424",title:"Dr.",name:"Tristan",surname:"Glatard",slug:"tristan-glatard",fullName:"Tristan Glatard"},{id:"22425",title:"Dr.",name:"Hugues",surname:"Benoit-Cattin",slug:"hugues-benoit-cattin",fullName:"Hugues Benoit-Cattin"},{id:"22426",title:"Dr.",name:"David",surname:"Sarrut",slug:"david-sarrut",fullName:"David Sarrut"}],corrections:null},{id:"14007",title:"Monte Carlo Simulation for Ion Implantation Profiles, Amorphous Layer Thickness Formed by the Ion Implantation, and Database Based on Pearson Function",doi:"10.5772/14539",slug:"monte-carlo-simulation-for-ion-implantation-profiles-amorphous-layer-thickness-formed-by-the-ion-imp",totalDownloads:5244,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Kunihiro Suzuki",downloadPdfUrl:"/chapter/pdf-download/14007",previewPdfUrl:"/chapter/pdf-preview/14007",authors:[{id:"18099",title:"Dr.",name:"Kunihiro",surname:"Suzuki",slug:"kunihiro-suzuki",fullName:"Kunihiro Suzuki"}],corrections:null},{id:"14008",title:"Application of Monte Carlo Simulation in Industrial Microbiological Exposure Assessment",doi:"10.5772/15283",slug:"application-of-monte-carlo-simulation-in-industrial-microbiological-exposure-assessment",totalDownloads:2854,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Javier Collado, Antonio Falcó, Dolores Rodrigo, Fernando Sampedro, M. 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\r\n\tTruth is the first casualty of war, they say, and war is one type of crisis in the world today. In war or any other crisis, information is power, and misinformation or disinformation empowers some and disempowers others. This volume will explore the use or the accusation of “fake news” and other kinds of false or falsified knowledge (conspiracy theories, hoaxes, suppression of facts, false flags, science denial, etc.) in the context of multiple concurrent crises in the contemporary world, from war and pandemics to climate change, economic emergencies, right-wing populism, and recurring gun violence. Contributions from a variety of disciplines and with an international perspective examine how fake information in all its forms is activated to outrage, confuse, and motivate the public, while accusations of fakery against scientists, journalists, and academics serve to discredit, marginalize, and silence potential opposition to the interests of corporate and governmental players. The studies illustrate that fake news, propaganda, strategic communication, and information warfare are exercises of power that create a fog of doubt and ignorance to interfere with public discourse and cripple public action.
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1. Introduction
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In outlining what leadership really means, this chapter begins by looking at the concept differently. There is a need to understand the relationship between what leadership is and what it means. It is debatable whether leadership is for everyone, perhaps because people generally look for particular traits that entice them to follow their leaders [1]. This assumes that people always have a choice or say, in whoever ascends to the leadership position. Nevertheless, it is not always the case. What if they do not get to pick, but rather have to work under the leadership of a person who has been appointed into that position, particularly in a working environment? Either way, comprehending social process facilitating opinions influencing leadership provenance is essential, because leadership is a social occurrence [2, 3].
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Jenkings [4] argues that people are not naturally inclined to be ruled and or led, because leadership is a construct designed to serve specific purpose/s such as maintaining inequalities. This possibly maintains a particular social order. The implication is that if people are not prone to be reigned as expected, and yet there is a need to have social order, those charged with a role to lead have need to exude a capacity to influence conduct in achieving a specific purpose. In an educational context such as a school, the expectation is to have a well-run institution that inspires agreeable values instilled by a leader to achieve anticipated outcomes. For that reason, school leaders are charged with a responsibility to influence such desirable conduct. This assumes that these leaders have abilities or traits that enable achievement of these expectations [5], particularly in a socially demanding context. Which begs the questions; to what extent does the leadership role serve as a gatekeeping function? Why do leaders exist? What happens in a situation where there is no one assuming the leadership role?
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We need to discern the purpose of leadership and leaders. In most instances, the two concepts are used interchangeably, yet there is a difference. First, the difference is outlined. Webb [2] makes a distinction that doing leadership activities does not translate into being a leader and thus offer an example that leadership is an ability to cast a vision whereas a leader is visionary. The purpose of leadership is to be a vanguard or hold a position and perform responsibilities [6]. To be a leader is to have transcendent authority [2]. Leaders are able to cultivate a culture that makes it possible for others to rally in unison around a particular common purpose because they employ influence [7]. What happens with a leader who is unable to inspire others? How can they be capacitated to lead through influence towards achieving desired outcomes, particularly in an extreme school setting?
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Leadership exists because there is generally a belief that the buck needs to stop with someone. Schaeffer in [8] justify this by stating that “leadership is more than heavy handed at the top”. Allio in [7] is of the view that leadership is “elusive” because of the commanding forces that cannot be detected but keep acting on its process. Other authors view leadership as a conglomerate of leading personalities teaming up to lead and having a leader who directs this team [5, 7, 9, 10, 11]. In contrast, leaders have deep-rooted drive to achieve their purpose in a way that arouses others to follow them. They are efficient, whereas those in leadership are effective [2]. Therefore the assumption is that because this is the case, leaders can be able to hold others accountable and push them to achieve specified goals. Hence the push by leadership education conglomerates to design a curriculum or plan that enables attainment of the state of efficacy so that leaders can emerge to drive strategic objectives in a most cost effective way to maximise profit or achieve the highest possible outcomes to proof competence or success, particularly related to political gains or academic capitalism. Sometimes at the cost of social contract between leaders and those working under them. Therefore, leadership in this context is a construction building towards show of efficient leader’s practice [12]. This then backs the question, what do leaders need to do to achieve leadership objectives whilst engaging social process in educational spaces.
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This question borders on the understanding that success in leadership requires intense continuous development of leaders and their identities, particularly in a schooling context.
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2. Leading and leadership in education
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Sources about leading and leadership in education repeatedly point to the significance of leading successfully and detail ideal types of leadership for various reasons, stemming from habits and social phenomenon [13], socialisation and leader identity [14], leadership in extreme contexts [10] and values driven leadership for improvement of performance [15, 16, 17]. In order for us to probe the context of this purported success, we need to identify the constructs associated with this achievement. First, the conception of an individual/s holding the position has to be understood.
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Coming to grips with the individual when leading and holding the lead position in an education space is important. Conceptualising the traits that drive action by the person of the leader marks their personal identity. A leaders’ persona marks his/her individual identity. Authors in [18] propose a deindividuation phenomenon to deepen understanding on the identity of a person (leaders in this context) and suggest that there are two possible states of being; primarily is an individuated leader in this context, acting in a coherent and judicious way; and then again there is a leader acting without limitations or thought because his/her individuality is submerged. The individuation process of a leader therefore signifies their purpose and role in leading the condition under which this role occurs within a social context [19]. Therefore the social context and factors could possibly be significant to determine the individuality operation of a leader. This is based on both empirical results and theoretical groundworks [5, 12]. The ostensible constructs include; the notion of influence and rational persuasion, the attributes of decisiveness and action, ability to collaborate, and appeal of the general behaviour due to charisma and transformative abilities [20]. The notion of leading as a dynamic contradictory and enigmatical construct is hereunder constructed through; the notion of influence and rational persuasion, the attributes of decisiveness and action, ability to collaborate grow appreciation and appeal of the general behaviour due to charisma and transformative abilities.
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2.1 The notion of influence and rational persuasion
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A Leader is a person deemed to have the ability to influence juniors or followers [5]. Influence in its nature has elements of social interrelation. This could disputably be because influence is a positive or negative shared social phenomenon affecting conduct. Influence is said to be a social phenomenon refers to people’s understandings regarding others’ values, beliefs and mannerism’s inspiration on their behaviour and decisions [21]. Once people are inspired, they become persuaded and are inclined to follow what inspires them wilfully.
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Leaders need to have the capacity to influence and inspire others so that they are persuaded to listen and comply with requirements they set out. Once people are persuaded, they may attach value and believe in what the leader require and or expect from them, which in turn, may inspire compliance, particularly in achieving desired results. Compliance refers to a response and urges influencing action or conduct in a desirable manner [22]. Usually this happens to foster wilful conformity. Leaders who manage to attain intentional compliance generally exude capacity to influence through rational persuasion and are arguably decisive in taking action to achieve this.
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2.2 The attributes of decisiveness and action
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A leader is generally considered an individual who can shape the social and or cultural context under which s/he operates. There is nothing like the best set of attributes or style of an ideal leader for all conditions [23]. However, decisiveness is conceivably an essential ingredient in whatever attributes a leader exude. Equally, a leader’s role is feasibly action oriented. Even though leaders are responsible to get things done and achieve requisite outputs, their influence cannot be cohesive if their focus is only intended at accomplishing objectives, rather than being aware of socially constructed practices that they can conceivably employ to produce positive action [24]. A school leader for instance, needs to be aware of the proverbial social issues—ranging from hardcore negative attitudes to subtle tendencies of racism and ethnicity—threatening progress in their institution, and come up with realistic strategies to eradicate these matters. Conceivably, such decisiveness and action are desirable qualities for assuming purposefulness in the role of leading. In such instances, continuous support and development of leaders is required to sharpen their skills, enhance their ability to lead and recognise the socio-cultural factors of influence that can improve and advance their role to lead by taking necessary action [25].
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Putting plans to action require taking critical decision making and preparations. There has to be consultations, collaborations formed and agreements for the successful execution of plans, particularly in schools that require performance improvement [26]. It is important to consider the proximity of relations between leaders and those working under them in considering successful actualization of plans. The psycho-social distance can influence the sort of actions leaders in organisations take and its members [10]. It is important to understand the deeper drive constituting the conceptualization of traits needed by a leader in influencing practices through collaboration and informed actions.
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2.3 Ability to collaborate and grow appreciation
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The education sector in general and schooling system in particular within South Africa, needs leaders who are able to find a way to weave together a substantial effort, determination and rally people to achieve desired outcomes. A school leader needs to have the ability to entwine collaborative ideas and encourage participation by all stakeholders in the school if they desire to enjoy support and create a conducive social participation [27]. Sharing and allocating responsibilities among teachers and other parties involved in the running of the school is important to achieve collegiality and should include encouraging collective reflection and decision making [28].
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For collective decision making and creativity to take place, there should be a concerted effort to improve the morale and tackle social snags when they crop up without bias [27]. This necessitates continuous development of leaders to enable them to come up with initiatives that will feed into collaborative activities. During this process, leaders need to appreciate efforts through the show of gratitude. Building shared creativities and amassing the necessary support demands conscious continuous development of leaders [29]. Leaders need constant support and development to keep up with the changing demands of their positions and enhance their transformative prowess particularly in schools. In turn, they can cope with what confronts them as they lead, mainly when confronted with issues that relates to collaboration, social cohesion and taking action.
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2.4 Appeal of the general behaviour due to charisma and transformative abilities
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The ability to build-up collective effort can practicably, directly lend itself to having a capacity to change perceptions and encourage will to transform. School leaders need to have the capacity to maintain social relations and cultural considerations in bringing together all parties with an intent to shape conduct and transform practices to achieve institutional goals [30]. The argument furnished [31] is that even though leaders are believed to have influence, little is said about the manner and extent to which such influence have to shape actions. This could have an element of bias because there is no clear framework guiding such actions. For that reason, putting emphasis on the notion of influence and appeal may inadvertently cause tendencies that resist transformation [8].
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The measure of succeeding in providing inspiration necessitates charting programmes of development for leaders, specifically focusing on honing abilities that enable leaders to adjust and embrace changing terrains, often caused by unintended occurrences. The argument furnished is that leaders in schools do not necessarily have capacity to inspire transformative practices in the absence of clearly articulated standards for school leaders’ qualification [32]. Backing the assertion that leaders’ mission is to advance a particular purpose, often related to achieving interests of other powers elsewhere as discussed in the introduction. Hence the push for prescriptive qualifications to entrench that which seeks to evoke an appeal of a conduct inspiring charisma and transformative abilities [32]. This includes the shift from knowing what to do, to doing what needs to be done, regardless of the context.
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3. Leading and leadership development within socially demanding contexts
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Leaders are expected to lead within all contexts, specifically those that demand prowess of their abilities. Demanding contexts require a leader who is able to accede to the trying environments and deal with difficult or extreme incidences as they occur. Hence the need to develop them. The need to help leaders apply what they learn to their context is confirmed [5]. However it is important to highlight that what is learned should add to the understanding of varied modalities of tackling problems so that leaders are empowered to initiate their own ways of resolving issues within their situations, which may not necessarily be the same as other circumstances or contexts.
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Often what is learnt is hardly practiced, which suggests that what is taught may not necessarily be relevant to what leaders need to know and be able to use when devising ways to address issues in demanding contexts [33]. Difficult contexts arguably require leaders who are decisive and can act swiftly or deal with whatever issues cropping up at any given time, within their practice. The three components when leading within challenging contexts found to be significant are; dealing with problems directly related to the school context, being people-centered by adopting the values that prioritise people over the organisation, and promoting collaboration and moral purpose [34]. The preceding discussions expose the key considerations when planning for leaders’ development; content provisioning should be personalised, socialised, adaptive and context based for leaders.
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3.1 Personalised provisioning to build capacity
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Leaders in difficult contexts need to be social change agents. However, there are no two contexts that have the same difficulties. Hence it is essential for trainers and providers to structure development programs for leaders in a manner that equip them with skills that can enable them to deal with issues as they crop up and themselves be able to build capacity or organise capacity building for all stakeholders in their institutions.
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There is a need for provisioning of dependable support for school leaders to accede to the demands of changes in education, effectiveness and improved quality of education, and so that they can develop and shape the direction of their schools [25]. The capacity development is vital for improving knowledge and skills, particularly intending to attain co-operation and develop a culture of quality performance [35]. Personalising such provisioning according to the needs of the leader can possibly have immediate and direct impact on their practice and provide them with skills to promote collaboration.
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3.2 Socialising practice to promote collaboration
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Leaders in schools have to understand their role and its impact on practices within their contexts. This includes contributing towards social values and educational ethics; having competency in critical skills and knowledge set that is fundamental for accomplishing the demands of their role successfully; and possessing the professional attributes that can enable them to succeed in leading others collaboratively [25]. Learning to push for social practice in order to promote collaboration is crucial and ought to form part of the school leaders’ development plan.
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Without the understanding of collective practice, and the extent to which such practice can help transform and or improve performance, school leaders may struggle to enjoy the support of all stakeholders and run their institutions through a shared process. Leading a successful school does not rest on the leader alone, but relatively on a collective responsibility that nurtures leading collaboratively [35]. To make this process bearable, it is essential for leaders to distribute their process of leading in a manner that fuses an element of democracy, without losing sight and grip of the purpose for which such process is meant. This implies embarking in a collaborative way of accomplishing goals that can be done by considering all inputs and collectively deciding on the best solution.
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Coherence, unity and shared focus on agreeable deliverables allow for power sharing and common understanding of institutional goals [36]. The role of leaders in this instance is to guide the process towards achieving agreeable results. Thus, shared values, can be used as a scaffolding to bridge such significant social process [15]. Scaffolding the process of leading makes others want to emulate their leaders while complying and carrying out duties as well as responsibilities because they understand the importance of working together for a common purpose. This requires properly planned provisioning for leaders, that supports development of self and others.
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3.3 Planning leaders’ development provisioning that is adaptive
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The prosperity of any institution rests on the leaders’ ability to support development of others and being dedicated to pursue own professional development [37]. This requires knowledge of: the manner in which performance management is associated with planned improvement and continuous development; approaches linked to skilled development and adult learning; the promotion, implementing and encouragement of collaborative leadership; and the importance of Ubuntu inspired leadership [25].
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Leaders are expected to demonstrate their headship through the implementation of planning processes, show of equity and fairness, and encouraging participation by initiating collaborative activities particularly in socially demanding contexts [37]. However, Ahn warns of the possibility of resistance, particularly when there is suspicions favouritism or the practice of the “Russian Doll” phenomenon, a process seen to be superficial and favouring the leaders’ picks [8]. The majority of demanding contexts are thwart with such practices among others [35]. It is therefore important to plan for leadership development programme for school leaders that will particularly enable them to act prudently.
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The Chinese use two social values termed Confucianism and Guanxi. Confucianism based on hierarchy and relating, where leaders with more resources and power are highly regarded and honoured than leaders having lesser means and power [38]. Guanxi is an element of confuciation in which emphasis is on personal connections, more of “whom you know is more important than what you know” [38]. This has a potential to negate all good intentions the leader has to form successful collaborations, particularly if it is not understood by all involved and is not explained. Consequently, amassing skills to navigate such processes successfully is important, particularly in an attempt to re-write the narrative about leading differently and re-looking the social construction of leading, particularly in socially challenging contexts.
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3.4 Context centered leadership development
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There is a need to explore the extent to which successful leaders are able to react and adjust to various contexts [5]. Deeper appreciation of the mechanisms and ontology of leadership practices and impact resides with all those charged with the responsibility of leading specifically, and those they lead in general. Understanding how leaders adapt and respond to varied contexts warrants considering different approaches successful leaders employ. It is a process that overall, necessitates a coordinated collective working collaboratively and be aware of their context [39] Hence the necessity to provide development suitable for such leaders’ needs.
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Leadership in recent times, is considered a team practice [5]. The art of influencing collective effort, when leading to a point where stakeholders consider themselves partners within the terrain of leading has a potential to heighten collaborative intent. Carsten and Uhl-Bien in [39] found in their research that followers see themselves as associates in the process of leadership and as a result are productive, hence they work better and desire to achieve more. Therefore development of leaders in contexts where leaders are embraced and stakeholders consider themselves leaders in their own right, ought to strengthen these acts of goodwill by equipping leaders towards leveraging on such practices in their course to create space for leading collaboratively and influencing practices.
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3.4.1 Influencing practices
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Sometimes, initiating activities and or programmes that are unpopular and not favoured may prove problematic, particularly in challenging contexts. This is where the application of social values such as guanxi may be useful to garner necessary support towards having a ripple effect of diffusing action that influence the embracing of change and different ways of doing things. There is nothing wrong with leaders having a core that help them overcome institutional cultural obstacles in their attempt to influence conduct and effect necessary change [39].
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In developing own relations when leading, it is essential to make it clear that the covert dyadic ties established to have someone or a core representing people a leader can rely on, should be based on work and ensuring that full support of the leaders’ initiative ignite influence of others. A core in this instance resembles a relationship between a leader and nucleus members forming the chromosome group from which action launch. This core comprises trustworthy individuals who have bought into the vision and are willing to roll-up their sleeves to get work done. They agree to be sent on a high authority mission requiring fearlessness and awareness of the task at hand with mutual trust intact and are a de facto link to the leaders’ office because of their social attributes [40]. The individual or core in such instances are entrusted with a responsibility to be an expanded influence cohort. Such initiatives should be context based and meant for a specific social course [41]. Leaders need to be prepared towards developing such core if they are to make headway concerning achievement of goals, particularly in difficult contexts.
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The critical operative value of the core is founded on trust. Trust forms the bedrock for institutions and is arguably essential to build strong relations for effective collaborative social action. It is essential for achieving the potential collective benefits of scale and scope and should extend beyond personal and individual relations to mutual trust [42]. The operative principles at play in this instance are openness, transparency, trust (as a value) and authenticity to achieve bilateral, institutional, and relational trust. Bilateral trust is based on fairness, stability created, and predictable collective routines established based on the institutional norms, whereas institutional trust is founded on processes, principles and norms within the organisation [43]. Relational trust happens when all parties demonstrate a willpower to work hard towards achieving goals [44]. When power dynamics are uneven, it is essential for school leaders to specifically, be the key drivers of trust [43]. Once trust is established, leaders in socially distinct contexts (particularly in socially demanding education contexts) can influence practices and build teams.
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4. Leading and leadership within socially distinct contexts
\n
Leading occurs in various social contexts among of which are schools. Schools operate in vast social contexts influenced by socio-economic, techno-cultural and religious factors. The vastness of these social factors directly has a bearing on the quality of leading and leadership as well as the school functionality. Excellence in leadership at various levels of the institution is connected to the attitude of its employees, performance, climate and the conduciveness of the environment [45] as well as existential factors. Leaders are expected to ensure that what needs to happen, happens with the involvement of all concerned stakeholders. However, context and social elements matter and mainly influence the extent of leading and leadership success. This is because the functionality of leaders is determined by the characteristics of both the leaders and followers [12].
\n
In general, context matters and thus the social dynamics at play and the leadership, serve as the best abettors regarding the institutions’ state of functionality. The relationship between the leader and followers has a direct bearing to the prevailing conduct and functionality of the school [12]. Based on such relationship, the elements at play are socially constructed and define the context. Contexts vary from excellent performance and functional to difficult and underperformance. Excellence and functionality can be juxtaposed to favourable social conditions and contexts whereas underperformance and extreme contexts may be placed alongside unfavourable social situations.
\n
\n
4.1 Contexts of excellence
\n
One of the key factors found to be foremost in leading excellent contexts is the ability of leaders “to get things done by working with and through people” [46], regardless of the socio-cultural conditions within their setting. They seem not deterred by the circumstances and factors often attributed to the reasons of underperformance in other institutions. The question is, what makes institutions, particularly those operating in extreme contexts excel? For any institution to succeed, there is a need for stakeholders to pursue greatness, in turn they need skilled leaders that can create enabling working conditions [15]. Institutional excellence can be summarised according to the following abilities:
Encouraging self-regulated interaction and support among members of staff.
Inspiring a vision and following-up by modelling a way to achieve the vision.
Involving stakeholders in decision making processes and clarifying the reasons for taking such decisions and acting on them.
Striving to build strong teams and aggravating collaborative action.
Creating a safe and conducive environment where everyone feels free to perform.
Inspiring values that guide conduct and practices.
Have authority to act decisively, take crucial decisions and embark in courageous conversations [12, 15, 45, 46].
\n\n
When planning a context based development program for school leaders, it is important for service providers to consider designing the provision of their programmes in line with the aforementioned abilities to graduate leaders that are able to succeed in their contexts.
\n
\n
\n
4.2 Extreme contexts
\n
Leading in extreme contexts largely remain a path for deeper exploration. Contexts that are extreme can be categorised as environments that exist under difficult conditions and are mostly characterised by chaos [11], intolerable circumstances [10], underperforming contexts [15, 16] and challenging contexts [9, 35]. In all these situations, the contexts are fraught with negative social issues that, to a great extent, contribute to the situation. Often these extenuating circumstances are arguably propelled by subtle forces that manage to somewhat spread a wave of negative atmosphere. Because education spaces were sites of contesting for alternative kind of society [11] and perhaps social order in fighting the apartheid regime in South Africa, most stakeholders in these spaces, particularly in extreme contexts have not unlearned resistant attitudes and related conduct. Hence the chaotic and underperformance challenges continue to be, among others, prevalent. Problems in all these situations are said to be traceable back to policy processes and documents inclusive of the national development plan (NDP) (Kriel in [11]).
\n
In light of the above, the circumstances under which leaders in these contexts’ work is discouraging. Resulting into low level of motivation and inability to account for occurrences and poor performance in their institutions [16]. They often have a sense of powerlessness and are not able to turn their situation and performance around [9]. Apparently intensifying the performance agreement of leaders can enable the correct improvement because such agreements are linked to development [16]. Sadly most of such performance agreements in these contexts are said to be superficial [11], implying that whatever development scheduled from such outcomes, may equally not address the real areas for development for these leaders. Consequently, leaders’ practices and school context in this instance are symbiotic. Getting the leaders’ act right through targeted development programme and improving practices can possibly help turn the situation of their institution around and enable a suitably constructed social order within such spaces.
\n
Leading within distinct contexts require concerted effort to disrupt the patterns and attitudes that perpetuate disorder by intently focusing on developing leaders in such institutions to act decisively and change the prevailing narrative. Zeichner in [11] argues that restructuring of these sites to be more collaborative and professional is linked with social problems such as contradictions and tensions. Therefore, there is a need for leaders in such contexts to disempower these social challenges and assume authority. Achieving this colossal intention, necessitates a development of judicious and socially structured process of leading and learning change methods. This chapter proposes the following, to construct such social process:
Leaders’ development programme featuring self-directed electives that provides for needs specific content, to help participants enrolled in such programmes to acquire skills that can enable them to transform or maintain good practices in their institutions.
Onsight learning programme that offers opportunities for leaders to implement what they learn and intently inspire the will to learn and improve.
Considering the values inspired by confucian and guanxi practices, leaders need to make a concerted effort towards formulating a problem based collaborative collective core, based on practices that focus on the needs, limitations and opportunities within working spaces to disrupt the scourge of social problems and turn around practices. However, they should be mindful that others are not side-lined in the process, but rather graduated to other specific collaborative cores intended at addressing various social problems.
Periodic reviews should be planned for reporting and to allow for critical reflection of collective progress and effectiveness of formed collaborations.
Institutional collective agreement of tackling issues of competency, conduct and performance to increase ownership in addition to inspiring and strengthening the values of responsibility, responsiveness, Ubuntu and compassion.
Leaders need to develop a personality ethic that is informed by sawing the seeds of greatness to shape their character ethic.
Showing gratitude to strides made in achieving goals and striving for success.
\n\n
The above directly respond to the department of basic educations’ (DBE) strategic priorities in response to the realisation of schooling 2030 action plan in South Africa [25].
\n
\n
\n
\n
5. Conclusion
\n
The chapter provided a distinction between leadership and leading in varied social contexts. Leading is considered a dynamic contradictory and enigmatical construct constructed through; the notion of influence and rational persuasion, the attributes of decisiveness and action, ability to collaborate, growing appreciation and appeal of the general behaviour due to charisma and transformative abilities. The chapter further submits that leading and leadership development within socially demanding contexts require socialising practice to promote collaboration. Further, it is important to plan for leaders’ development provisioning so that it is adaptive and context centered. Such leadership provisioning is important to influence development and improve practices. Development of leadership provisioning needs to further equip leaders with skills and abilities to lead within socially distinct context, particularly in schools. Finally, the chapter proposes considerations for constructing a social process for leaders to assume authority and have a voice to lead decisively inspired by shared values. Future studies could probe possible issues getting between the leaders and their success.
\n
\n\n',keywords:"leadership, deconstruction, development, preparation, social deconstruction",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/70620.pdf",chapterXML:"https://mts.intechopen.com/source/xml/70620.xml",downloadPdfUrl:"/chapter/pdf-download/70620",previewPdfUrl:"/chapter/pdf-preview/70620",totalDownloads:665,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:10,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:"August 30th 2019",dateReviewed:"November 25th 2019",datePrePublished:null,datePublished:"March 18th 2020",dateFinished:"December 24th 2019",readingETA:"0",abstract:"In this chapter, leadership is examined through a socially constructed process. Focus is directed at being able to engage alternative perspectives regarding leadership and a leader, and the significance of professional development in developing leaders’ capabilities and characters. Through the lens of leading and leadership, an outline of understanding leadership as a construction is presented, by exploring the notion of leading as a dynamic contradictory and enigmatical construct within the leadership discourse generally and educational leadership in particular. While educational leadership has largely been topical over time, leading and leadership development within socially demanding contexts largely remains a path for deeper exploration. Moving through various levels to understand educational leadership better, the chapter channels attention on deconstruction of leadership through a socially constructed process, mainly focusing on leadership preparation and development for distinct contexts. There is a need to rethink the social dimension of leadership preparation and development to deepen the construction for the social process of leading effectively in education settings.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/70620",risUrl:"/chapter/ris/70620",book:{id:"8495",slug:"educational-leadership"},signatures:"Itumeleng I. Setlhodi",authors:[{id:"311181",title:"Dr.",name:"Itumeleng",middleName:null,surname:"Setlhodi",fullName:"Itumeleng Setlhodi",slug:"itumeleng-setlhodi",email:"setlhii@unisa.ac.za",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Leading and leadership in education",level:"1"},{id:"sec_2_2",title:"2.1 The notion of influence and rational persuasion",level:"2"},{id:"sec_3_2",title:"2.2 The attributes of decisiveness and action",level:"2"},{id:"sec_4_2",title:"2.3 Ability to collaborate and grow appreciation",level:"2"},{id:"sec_5_2",title:"2.4 Appeal of the general behaviour due to charisma and transformative abilities",level:"2"},{id:"sec_7",title:"3. Leading and leadership development within socially demanding contexts",level:"1"},{id:"sec_7_2",title:"3.1 Personalised provisioning to build capacity",level:"2"},{id:"sec_8_2",title:"3.2 Socialising practice to promote collaboration",level:"2"},{id:"sec_9_2",title:"3.3 Planning leaders’ development provisioning that is adaptive",level:"2"},{id:"sec_10_2",title:"3.4 Context centered leadership development",level:"2"},{id:"sec_10_3",title:"3.4.1 Influencing practices",level:"3"},{id:"sec_13",title:"4. Leading and leadership within socially distinct contexts",level:"1"},{id:"sec_13_2",title:"4.1 Contexts of excellence",level:"2"},{id:"sec_14_2",title:"4.2 Extreme contexts",level:"2"},{id:"sec_16",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'\nJackson J. Why should I be grateful? The morality of gratitude in contexts marked by injustice. Journal of Moral Education. 2016;453:276-290. Available from: http://0web.b.ebscohost.com.oasis.unisa.ac.za/ehost/pdfviewer/pdfviewer?vid=10&sid=67689cbb-b538-44cb-9855-1f4f91a8b1b9%40pdc-v-sessmgr03 [Accessed: 17 April 2019]\n'},{id:"B2",body:'\nWebb R, Vulliamy G, Sarja A, Hamallainen S, Poikonen P. Professional learning communities and teacher well-being? A comparative analysis of primary schools in England and Finland. Oxford Review of Education. 2009;35:405-422. DOI: 10.1080/03054980902935008\n'},{id:"B3",body:'\nVilas-Boas OT, Davel EPB, Bispo M de S. Leadership as cultural practice. Revista de Administração Mackenzie. 2018;19:1. DOI: 10.1590/1678-6971/eRAMG180076\n'},{id:"B4",body:'\nJenkins C. Deconstructing Workplace Hierarchies: On Contrived Leadership and Arbitrary Positions of Power. 2017. Available from: https://www.filsforaction.org/articles/deconstructing-hierachies-on-contrived-leadership-and-arbitrary-positions-of-power/ [Accessed: 30 August 2019]\n'},{id:"B5",body:'\nHallinger P. Bringing context out of the shadows of leadership. Educational Management Administration & Leadership. 2018;461:5-24. DOI: 10.1177/1741143216670652\n'},{id:"B6",body:'\nGunter HM. Leaders and Leadership in Education. Vol. 198. Sage; 2001\n'},{id:"B7",body:'\nAllio RJ. Leaders and leadership—Many theories, but what advice is reliable? Strategy & Leadership. 2013;411:44. DOI: 10.1108/10878571311290016\n'},{id:"B8",body:'\nAhn MJ, Adamson JSA. From leaders to leadership: Managing change. 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University of South Africa, Pretoria, South Africa
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1. Introduction
The European domestic pig breeds have been raised using the centuries-long process of domestication and artificial selection of its ancestor, the European wild boar (Sus scrofa scrofa) (reviewed in [1]). Domestication is considered the biological process of adaptation to management/breeding and results in the selection of unique morphological, behavioural, and production traits. Pig breeds experienced strong selection for specific production traits such as feed conversion efficiency, carcass composition, lean meat content and muscularity due to changing consumer preferences [1]. Compared with the wild boar, domestic pig breeds have also experienced a substantial increase in the litter size and growth performance. The mean wild boar litter size in Europe is between 4.75 and 6.28 piglets, whereas that in domestic pigs was 10.9 piglets in 1992, which increased to 12.2 piglets in 2001 [2, 3]. In Denmark, it was reported that 14.8 piglets were born alive in 2011 [4]. Similarly, the growth performance comparison between the wild boar and domestic pig showed that the domestic pig grows faster, with their body mass at the age of 5 months being four times larger than that of wild boars. Such immense growth intensity during the postnatal period in the domestic pig has been achieved through exceptional muscle mass accumulation, mostly due to myofibre hypertrophy and protein accretion, which is more pronounced in large white skeletal muscles [5]. Nevertheless, the heavy selection pressure posed on the modern pig breeds has also been associated with some negative/undesirable side effects including those associated with the musculoskeletal phenotype and carcass/meat traits.
The selection for increasing litter sizes leads to a decline in birth weight, thus increasing the incidence of low-birth-weight piglets (body mass < 1 kg at birth). This can be attributed to the intrauterine growth retardation due to insufficient development of the placenta in relation to the number of embryos, which are not sufficiently supplied with oxygen and nutrients [6]. Low-birth-weight piglets can exhibit a lifelong impairment in muscle growth, typically characterised by a decreased number of myogenic cell nuclei and reduced total myofibre number that are larger in diameter [3, 7, 8, 9]. Additionally, domestic pig muscles are less mature at birth compared to those of the wild boar [10]; the muscle immaturity could even be intensified in case of a bigger litter size/lower piglet birth weights [11, 12, 13, 14, 15]. The effect of a lower birth weight on the carcass and meat traits are inconclusive; however, most studies report that such piglets grow slower, have fatter carcasses, and poorer meat quality (higher drip loss and lower tenderness) (reviewed in [16]).
The selection and changed rearing conditions have also been associated with myofibre hypertrophy and a shift in the muscle myofibre type composition towards the fast-twitch glycolytic state [17, 18] as well as the introduction of certain causative mutations affecting economically important traits. Among the latter is a well-known point mutation in the ryanodine receptor (RYR1) gene (c.1843C > T) in stress-susceptible pigs [19], frequent in a heavy muscled modern pig breeds such as Pietren and Landrace pigs. It leads to an increased release of calcium from the sarcoplasmic reticulum due to different stress factors to which pigs are exposed. A higher level of calcium in the sarcoplasm induces hyper-contraction and hyper-activation of metabolic processes and can result in a sudden death, which in turn diminishes the meat quality after the slaughter. Due to an altered rate of glycolysis and a rapid fall of pH within the muscle, pale, soft, exudative (PSE) meat is frequently observed after the slaughter in pigs, particularly in the so called white muscles in which fast-twitch glycolytic myofibres dominate in number. Such meat is characterised by an abnormal colour, consistency, and water holding capacity, making the meat dry and unattractive to consumers [20]. This condition can also be observed in the white muscles of highly selected modern pig breeds that are free of the RYR1 mutation [21]. Extensive myofibre hypertrophy is also associated with the appearance of so-called giant myofibres, which are abnormally large and swollen and appear in post mortem muscles as a consequence of extreme hypertrophy, glycogen accumulation, and consecutive intracellular acidity due to excessive glycolysis [11, 15, 22, 23]. Additionally, giant myofibres were frequently observed in the white muscles of domestic pigs, but rarely in the red muscles or muscles of the wild boar or indigenous pig breeds. The percentage of giant fibres is closely correlated with diminished meat quality traits and lower pH measured 45 min after slaughter (pH1) [12, 14, 24, 25]. The possible reason for a negative impact of selection on meat quality could be because the increased muscularity was not accompanied with a proportional increase in the capillarisation of the muscle tissue. Accumulating evidences therefore suggest that the domestication and selection of the pig altered the development, growth, and the phenotype of the skeletal muscles to such an extent that meat quality could be compromised.
This chapter outlines the influence of domestication on myofibre formation and differentiation during growth and provides a comparative view on the developmental expression pattern of the MyHC isoforms, the activity of different metabolic enzymes, and the expression of selected genes responsible for the metabolic diversity of the myofibres. Additionally, there is a special emphasis on the type, composition, and histomorphological traits of myofibres.
2. Skeletal myofibre types, their classification, and characteristics
Skeletal muscle tissue is a major contributor to systemic energy homeostasis because of its high rate of energy demand and relatively large mass in comparison to other tissues and represents the biggest part of total body mass in mammals [26]. It is heterogeneous in structure, which results in the different contraction and metabolic properties of muscles. The muscle functional diversity not only allows various motor tasks, such as posture, locomotion, or jumping [27], but is also involved in whole-body energy metabolism as it is the major site for plasma glucose disposal [28]. In mammals, the skeletal muscles are a mixture of functionally specialised myofibre types with different contractile and metabolic properties. The initial classification of muscles/myofibres was based on colour and correlated with contraction speed and fatigability. For example, fast-twitch muscles, which are characterised by glycolytic metabolism and short-lasting but forceful contractions, are generally identified as white muscles. Conversely, slow-twitch muscles, rich in myoglobin and oxidative enzymes are specialised for more continuous or tonic activity and are defined as red muscles [29]; which also more effectively remove glucose from blood than white muscles [28].
Myofibre type diversity primarily depends on the structure of their myosin heavy chains (MyHCs), which are the principal myofibrillar proteins that control myofibre contractile properties. In the locomotor skeletal muscles of adult mammals, one slow (MyHC–I) and three fast MyHC isoforms (MyHC–IIa, –IIx, and –IIb) are generally expressed. MyHCs are responsible for the differences in the myosin ATPase activity and twitch characteristics between myofibre types. The contraction speed of MyHCs increases in the following order: –I < –IIa < –IIx < –IIb [30]. Myofibres may transform through successive steps of MyHC isoform expression i.e. from MyHC–I to –IIa, from –IIa to –IIx, and from –IIx to –IIb, and vice versa. In the locomotor skeletal muscles of large mammals such as cats [31], dogs [32], cattle [33], horses [34], and bears [35] only two fast isoforms (–IIa and –IIx) were demonstrated. However, all three fast MyHC isoforms were recognised in pigs [36], llamas [37], and also in some intrinsic laryngeal muscles of different species like the dog [38].
In pig muscles, the fasciculus myofibre type position follows the transition rule –I > –IIa > –IIx > –IIb and proceeded from the centre of the muscle fasciculus to the periphery [39, 40]. During prenatal and postnatal myogenesis, the developmental MyHC isoforms i.e. embryonic (MyHC-emb) and neonatal (also referred as foetal or perinatal; MyHC-neo) are also expressed. For this reason, hybrid myofibres, which contain more than one MyHC isoform are present in muscles and are numerous above all during myogenesis and early postnatal development or under the condition when different factors trigger the functional adaptation of the muscle such as exercise, changed endocrine status, neuromuscular stimulation, and inactivity.
The metabolic profile of the myofibres generally corresponds to the energetic demands of each MyHC. A greater oxidative capacity is characteristic for tonic or slow-contractile type I myofibres, which contain a higher amount of lipids as the main energy source. The IIb myofibres are predominantly glycolytic and use glycogen for strong, transitory contractions, whereas IIa and IIx myofibres represent the metabolically intermediary type between I and IIb myofibres [41]. Thus, the myofibre specific contractile and metabolic phenotype that correlates with MyHC expression and metabolic enzymes activity enabled an advanced immuno−/enzyme histochemistry-based classification of myofibres that relies on the specificity of the immunoreactivity of antibodies for different MyHC isoforms and histological assessment of metabolic enzyme activities as exemplified in Table 1 and shown in Figure 1.
Myofibre type
I
IIa
IIx
IIb
Antibody
NLC-MHCs
++
—
—
—
SC-71
—
++
+
—
BF-35
+
+
—
—
BF-F3
—
—
—
++
SDH
++
++/+
+
—
Table 1.
Immunohistochemical and succinate dehydrogenase (SDH) activity-based classification of myofibre types. Immunoreactivity of antibodies frequently used for myofiber type classification in pig muscles are presented.
+ and ++ denote moderate and strong positive reactions, respectively. +/− denotes weak reaction and – denotes a negative reaction.
Figure 1.
Antibody reactivity and SDH activity in the wild boar and domestic pig. Serial transverse sections of the longissimus dorsi (LD) muscle from the wild boar (upper row) and domestic pig (lower row) stained with the monoclonal antibodies NLC-MHCs, SC-71, BF-35, and BF-F3. Slow-twitch myofibres (type I) react with the NLC-MHCs antibody and all remaining unstained myofibres are fast-twitch type II myofibres. In the pig, the SC-71 antibody recognises both MyHC–IIa and MyHC–IIx myofibres; however, it has a higher affinity for MyHC–IIa. BF-35 recognises all MyHC isoforms, except MyHC–IIx and –IIb in the pig skeletal muscle. The BF-F3 is specific to MyHC–IIb myofibres. BF-35 negative myofibres are divided into two subgroups: Pure IIb myofibres (strongly stained with BF-F3) and hybrid IIx/b myofibres (weakly stained with BF-F3). Succinate dehydrogenase (SDH) activity demonstrates the oxidative potential of myofibres. Type I and IIa myofibres are intensively stained (highly oxidative) in both the wild and domestic pig, IIx and IIx/b myofibres are stained moderately and weakly, respectively and IIb myofibres are negative. Also, the difference in the myofibre diameter between the wild boar and domestic pig can be noted (cf. panels in upper and lower row). Scale bar, 250 μm is valid for all panels. (from Fazarinc et al., 2013 [17]. Reprinted by permission of Slovenian veterinary research).
3. Proportion of different types of myofibres and their histomorphometric traits
The MyHC expression pattern, which largely determines the proportion and myofibre contractile and metabolic profile (e.g. glycogen and lipid contents), also correlates with myofibre histomorphometric traits and consequently, the muscle to meat conversion and meat quality traits [42, 43]. In pigs, the oxidative and metabolic intermediate myofibres that express MyHC–I, –IIa, and –IIx are associated with desirable meat quality traits, such as the water-holding capacity, pH, and tenderness (reviewed in [44]). However, the domestication and breeding selection are associated with myofibre hypertrophy and changes in myofibre type composition with an age-dependent increase in the proportion of fast glycolytic myofibres [13, 15, 45]. In the white muscles of the domestic pig, the glycolytic MyHC–IIb positive myofibres prevail and are located in the peripheral region of the muscle fasciculus [36]. It was initially presumed that in the domestic pig, the MyHC–IIb isoform expression is related to genetic improvement and breeding; however, the presence of IIb myofibres was also demonstrated in the wild boar [17], albeit their number was sustainably lower as demonstrated by the difference of BF-F3 immunopositively stained myofibres in Figure 1.
The ratio of preferentially oxidative myofibre types is higher in the wild boar as well as some indigenous pig breeds than in the selected modern domestic pig breeds [10, 46, 47, 48]. The comparison of growing wild boars and domestic pig also revealed substantial differences in the direction and intensity of postnatal MyHC transformation and myofibres’ hypertrophic potential in the longissimus dorsi muscle [10, 49]. The MyHC differentiation is accompanied by the thickening of all myofibre types. Myofibre hypertrophy is especially intense in the period from 3 weeks to 7 months of age. In the domestic pig, the hypertrophy of all myofibre types is more intense than in the wild boar, especially that of MyHC–IIx and –IIb myofibres. The intensity of myofibre thickening markedly declines after 7 months of age [10]. The differences in the myofibre type, composition, and hypertrophic potential schematically presented in Figure 2 are based on the observations from our comparative studies [10, 17]. When the sizes of different myofibre types of domestic pigs and wild boars are compared, the cross-sectional area (CSA) of IIb myofibres is markedly larger than CSA of type I and IIa myofibres in the domestic pigs. The difference in the CSA areas of IIb and IIx myofibres is not so distinctive. In the wild boar, the sizes of all myofibre types are closer to each other. In the early postnatal period, the differences in CSA between the myofibre types are smaller, but when the pigs reach slaughter weight, the CSA of type IIb myofibres fibres is largest, especially in the white muscles. Notably, type IIb myofibres thickened faster than other myofibre types as a consequence of selection based on enhanced lean content which favours larger type IIb myofibres. The MyHC–IIb is the predominant isoform in the white muscle such as longissimus dorsi muscle, especially in the domestic pig and is the main factor that contributed to the increase in muscle mass. The co–expression of the MyHC–IIb and the MyHC–IIx is frequently regarded as the fine regulation of IIx and IIb gene expression in white muscles and is primarily influenced by the breed [50]. The assumption that the genetic background is a crucial determinant of muscle characteristics was further confirmed by a recent comparative study of young pigs of the Iberian and conventional breeds reared under identical conditions, the Iberian pigs had a higher intramuscular fat (IMF) content and oxidative metabolism in the longissimus dorsi muscle [51].
Figure 2.
Composition and hypertrophic potential of myofibre types in the longissimus muscle of the wild boar (WB) and the domestic pig (DP). (A, B) differences in the muscle myofibre type composition between WB (A) and DP (B) at the age of 2 years. Note that the proportion of oxidative type I, IIa, and IIx myofibres is significantly higher in the longissimus muscle of the WP (~65%) than in the DP (~38%). Contrarily, the proportion of glycolytic IIb myofibres was more than 2-fold higher in the DP (> 60%) than in the WB (~25%). (C, D) differences in the myofibre hypertrophic potential in WB (C) and DP (D) from birth to adulthood. Given are the values of fold increase in the cross-sectional area (CSA) compared to the CSA of myofibres I on day 1 in the case of type I myofibres. Hypertrophic potential of type IIa, IIx, and IIb myofibres was calculated relative to the CSA of type IIa myofibres on day 1.
Contrastingly, the published data about the proportion of type I myofibres in the domestic pig and the wild boar are contradictory. In some studies, a considerably higher proportion of type I myofibres was observed in the wild boar than in the domestic pig [10, 52]. On the contrary, other studies report that type I myofibres are even more numerous in the domestic pig than in the wild boar [5, 13]. Notably, the detection of type I myofibres is reliable, regardless of whether immunohistochemistry or myosin ATPase-based methods are used. Therefore, the reported differences cannot be attributed to the techniques used to identify type I myofibres and are probably triggered by rearing conditions. Recent studies also revealed that the muscle MyHC composition is influenced by additional factors, such as animal nutrition, physical activity and environmental temperature [39, 46]. Whereas domestic pigs are kept in farm breeding conditions and fed with typical commercial diet ad libitum, the wild boar is highly physically active on a daily basis as they ransack for food. This is probably the main reason for a higher percentage of slow twitch type I myofibres in the wild boar than that found in some other studies in which wild boars were kept in group housing with diminished locomotor activity and were fed ad libitum or when samples were obtained from animals kept in a zoological garden [13, 53]. Endurance exercise increases the proportion of oxidative myofibres along with the mitochondrial respiration of fatty acids, and our recent study with the Krškopolje pig, a Slovenian autochthonous breed, also showed the effect of the production system on the myofibre type composition; pigs reared in organic systems with outdoor space (spontaneous physical activity) have a myofibre composition shifted towards the oxidative (SDH-positive) phenotype [46].
Myofibre metabolism largely depends on the oxygen supply via an extensive capillary bed. Normally, a large number of capillaries are associated with oxidative myofibres and the ratio between the myofibre CSA to capillary is smallest in type I myofibres [54]. The capillary density per myofibre is almost equal in the wild boar and domestic pig. However, the myofibre area supplied by one capillary is larger in the domestic pig. IIb myofibres also tend to have lower numbers of mitochondria per unit area and are thus less oxidative and utilise glycogen to a greater extent than the red muscles, resulting in lactate accumulation in the muscles. When the myofibre CSA increases, the number of capillaries per area decreases, consequently, the extraction of lactate from myofibres is hindered. Therefore, pigs with smaller IIb myofibres in the white muscles should be selected, to overcome lactate diffusion problems in white muscles [45]. Conclusively, it is not the number of capillaries, but increasing diffusion distances due to increased myofibre size and lower capillary number per myofibre area, are related to the shift of the myofibres to fast-twitch glycolytic muscle characteristics in domestic pigs [5].
4. Developmental pattern of myofibre type formation
The typical arrangement of myofibre types in the fasciculus muscle of adult pigs is defined predominantly by prenatal development of the primary and secondary myofibres. The primary myofibre acts as a centre around which the myoblasts align and fuse to form the secondary myofibres. This process results in a unique distribution of myofibres consisting of clusters of type I myofibres surrounded by the fast type II myofibres. During the prenatal period, the primary myofibres express slow MyHC–I, whereas the fast secondary myofibres primarily express developmental MyHC isoforms. In the early postnatal period, the expression of MyHC–I also starts in the secondary myofibres that are in contact with the primary myofibres, meaning that they are transforming into type I myofibres, whereas the remaining secondary myofibres mature into MyHC–IIa, –IIx, and –IIb [40]. In the early postnatal period, the expression of slow MyHC–I increases and that of developmental MyHCs diminishes in the secondary myofibres that surround the centrally positioned primary myofibres [40]. The expression of the developmental isoforms of MyHC decreases towards the end of gestation, when they are substituted by the adult fast MyHCs in the following sequence: embryonic/neonatal > IIa > IIx > IIb. MyHC–IIa and –IIx are already co-expressed in the secondary myofibres at birth, whereas the MyHC-IIb first appears during the early postnatal period [55]. Regarding metabolic phenotypes, all myofibres are oxidative at birth. However, in parallel with the shift to the expression of adult MyHCs that occurs during the first postnatal weeks, a metabolic switch occurs as they differentiate into oxidative, oxidative-glycolytic, or glycolytic myofibres [56]. In the one–day–old wild boar, the proportion of transitional I/IIa myofibres is significantly higher than in the domestic pig (Figure 3), although there are no differences in the proportion of pure type I myofibres between both breeds [10]. This observation could indicate that the transformation of secondary (type II) into slow type I myofibres is faster in the longissimus dorsi muscle of the wild boar than the domestic pig at birth. During the early postnatal period, all three adult fast MyHCs (–IIa, –IIx, –IIb) are sequentially expressed. In this age period, the co–expression of two MyHCs in the same myofibre is frequent, indicating that the myofibre functional specialisation is intense. In the longissimus dorsi muscle of the wild boar, the distinct shift towards myofibres expressing MyHCs –I, –IIa, and –IIx is detected, whereas the number of MyHC–IIb-positive myofibres prevail in the domestic pig [10].
Figure 3.
Longissimus dorsi muscle of a one-day-old wild boar (WB) and a domestic pig (DP) stained with the monoclonal antibodies NLC-MHCs specific for slow-twitch MyHC–I. Positive immunostaining is observed in type I myofibres that originate from the primary myofibres and are located in the centre of the muscle fasciculus. Type I myofibres are surrounded by a subpopulation of smaller secondary myofibres (I/IIa myofibres). Type IIa myofibres are immuno-negative. Individual type I myofibres of domestic piglets still have a hollow centre (arrow) indicating the end of the myotube phase in myofibre formation.
After birth, thermogenesis in piglets almost exclusively depends on muscle shivering. Piglets raised in the natural habitat experience exhibit an increased exposure to the cold than those raised in farm conditions with lamp heating. Cold exposure during the early postnatal period and the consequent muscle activity (shivering) dramatically increases the expression of MyHC–I and decreases the neonatal MyHC [57]. This is the most likely explanation for the accelerated myofibre transformation towards type I observed in the wild boar during the first hours post–partum. Muscle thermogenic adaptation in terms of MyHC composition was also described in older pigs. An increased percentage of type I myofibres in pig muscles has been observed after prolonged (few months) cold exposure [57, 58]. Therefore, thermoregulation in the early postnatal period in combination with a higher physical activity is likely the main environmental factor triggering the myofibre transformation towards oxidative myofibres in which MyHCs –I, –IIa, and –IIx were predominantly expressed in the wild boar. Faster myofibre maturation in the wild boar was also confirmed with the antibody against foetal MyHC [10]. In the wild boar, the myofibres in the periphery of the muscle fasciculus were less intensely stained than in the domestic pig; thus, this provided additional evidence that the process of MyHC transformation from developmental to adult MyHCs is accelerated in the wild boar. Strong immunohistochemical reactions were mostly restricted to the myofibres that were in the vicinity of type I myofibres, suggesting that foetal MyHC expression progresses from the centre towards the periphery of the muscle fasciculus in the early postnatal period. A decrease in the foetal MyHC is first observed in myofibres in which expression of MyHC–IIx and –IIb started, followed by IIa myofibres. Hence, the transformation of type II myofibres into type I, the decline in the expression of developmental MyHC, and its subsequent replacement with the adult fast MyHCs isoforms are strong criteria for the estimation of myofibre differentiation in the process of postnatal muscle development.
The determination of foetal MyHC isoforms can also present a useful model to investigate the hyperplastic muscle potential during postnatal growth. Small irregularly scattered foetal MyHC–positive myofibres are present in the first postnatal weeks in pig muscles and are designated as third-generation myofibres. The third-generation myofibres had a very small diameter and are randomly scattered among the normal-sized myofibres and displayed a positive immunohistochemical reaction with antibodies against foetal MyHCs (Figure 4). These data suggested that the total myofibre number in pig is determined after birth, mainly in the first postnatal weeks [40, 59]. This myofibre population are more numerous in the domestic pig than the wild boar [10] and could contribute to an extraordinary muscle growth potential in domestic pig breeds and probably contributes to the post–natal increase in the total myofibre number. Isolated small foetal MyHC–positive myofibres are observed in pigs in the later growth period and probably represent activated satellite cells [10, 60]. Nevertheless, their number in older pigs (7 months) is probably too low to substantially contribute to the post–natal myofibre hyperplasia. Therefore, we assume that the estimation of the post-natal effect of foetal MyHC–positive myofibres on the hyperplastic muscle growth potential in the wild boar or the domestic pig is limited after the first postnatal weeks. It is obvious that the disappearance of foetal MyHC is much faster in the wild boar than in the domestic pig (Figure 4). Evidently, domestication and selection of the pig has substantially changed the ontogenic development of the pig skeletal muscles, especially the white muscles.
Figure 4.
The longissimus dorsi muscle of a 3-week old wild boar (WB) and a domestic pig (DP) stained with the monoclonal antibody F158.4C10 against the foetal MyHC. The number of immunopositively stained myofibres (pale to dark brown) still expressing foetal MyHC is higher in the DP than in the WB. Additionally, immuno-positive myofibres with a very small diameter, representing the third generation of myofibres, are present.
The differences in the MyHC transformation pattern/muscle development between the wild boar and domestic pig were additionally confirmed with the qPCR analysis of MyHC isoforms at the mRNA level [49]. The most significant changes in the MyHC transcript levels in the longissimus muscle in both breeds occurred during the initial three postnatal weeks. From 1 day to 3 weeks postnatal, the order of MyHC transcript levels changed in the following order: IIx > IIa > I > embry > IIb to IIx > IIb > IIa > I > embry. Although this pattern of postnatal transition was identical in both breeds, the quantitative changes were substantially different between the breeds. MyHCembry expression disappeared approximately 10-fold faster in wild boars than domestic pigs, whereas MyHC–IIb increased to substantially higher levels in domestic pigs. A positive correlation between the relative amount of each individual MyHC mRNA and its corresponding protein in the longissimus dorsi muscle has been demonstrated in growing commercial crossbred pigs [61]. These results support the hypothesis that the MyHC genes are directly transcriptionally regulated in porcine skeletal muscles [56, 62]. One of the developmental MyHCs that prevail during gestation is MyHCembry. Developmental MyHCs are then replaced by adult fast MyHCs (i.e. MyHC-IIa, –IIx, and –IIb) in the late gestation/early postnatal period. The MyHCembry expression level thus reflects muscle maturity. MyHCembry was also reported in 6-week-old domestic pigs [63] and could be associated with slower muscle maturation or appearance of the third generation of myofibres, which could contribute to myofibre hyperplasia in the muscles of domestic pig [63]. The higher MyHC–IIx expression level observed in newborn wild piglets provided additional evidence that myofibre maturation and the replacement of developmental with adult MyHC was accelerated during the first post-partum hours in 1-day-old wild piglets.
5. Hyperplastic potential of pig muscles
In pigs, the skeletal muscle growth potential could be also characterised by the dynamics of age-related changes in satellite cell proliferation and differentiation. Postnatally, satellite cells play a crucial role in the muscle development, growth, and regeneration [64, 65]. They provide the cell nuclei for muscle fibre fusion and growth and are able to terminally differentiate into myofibres. Adult satellite cells are mostly quiescent and express the transcription factor Pax7 and Myf5 when they enter into the myogenic phase [66, 67, 68]. Activated satellite cells undergo proliferation and subsequently, myogenic differentiation to finally form new myofibres or fuse with existing myofibres [65]. In addition to Pax7 and Myf5, the proliferating myoblasts start to express MyoD (myoblast determination protein 1). The myocytes downregulate Pax7 and upregulate the differentiation marker myogenin (MyoG) (reviewed in [64]). During the first postnatal weeks, up to 60% of cells isolated from piglet muscle belong to the satellite cell population and 90% of them are in a state of proliferation [65]. Between the weeks 7 and 21, the percentage of satellite cells lowers dramatically and in adult pigs only 2–5% of cell nuclei belong to the satellite cells [69]. The size of the satellite cell pool established during early development is crucial for the lifelong muscle performance [68]. Additionally, these data indicate that a high percentage of satellite cells remain proliferative during the early rapid postnatal muscle growth and probably represent a third-generation of myofibres. Satellite cell differentiation is likely to modulate the muscle growth because it regulates the accretion of DNA in muscle fibres as well as the number of satellite cells that remain capable of proliferation. Quinn et al. [70] demonstrated that embryonic myoblasts isolated from foetal calves with the double-muscled phenotype display a delay in differentiation compared with myoblasts isolated from normal foetuses. A similar discrepancy in differentiation and formation of the myofibres between the wild boar and domestic pig was confirmed with in-vitro growth kinetics of muscle satellite cell cultures derived from domestic and wild-type pigs and analysed by changes in DNA and protein content. Domestic pig muscles exhibited lower numbers of myofibres and were less mature at birth, as seen by DNA, RNA, and protein composition, whereas the satellite cell from the neonatal muscles of wild boar showed intense growth. Contrary to the observation on the first day of age, the RNA/DNA ratio was higher and DNA/protein as well as nuclear density were significantly lower (at unchanged protein/RNA) in domestic pig muscles at 7 weeks of age, suggesting that protein synthesis has mainly increased at the transcriptional level, resulting in excessive myofibre hypertrophy in the domestic pig [5].
We can conclude that relative immaturity of domestic pig skeletal muscle in terms of cellular development at birth is followed by an explosive postnatal myogenesis, leading to the final superiority of domestic pig muscles in protein accretion. Furthermore, a small contribution to higher muscle mass has been realised by additional myofibre formation shortly after birth but mostly in large skeletal muscles such as the semitendinosus muscle. Therefore, the major difference in muscle mass between the domestic pig and wild boar has been realised through a substantial increase in the postnatal protein accretion and myofibre hypertrophy [5].
6. Expression patterns of genes involved in myofibre metabolism
The expression patterns of genes that regulate different aspects of energy utilisation are becoming of significant value in pig muscle studies. On the basis of an increased expression of MyHCs –I, –IIa, and –IIx and parallelly increased SDH activity in the myofibres of wild boars, certain differences in the expression of the genes involved in the energy metabolism in the myofibre are expected. The glycolytic cycle is particularly important for lactate formation in the muscle. The phosphorylation of glucose to glucose-6-phosphate is controlled by hexokinase (HK), which is the key enzyme in the glycolysis reaction, and HK2 is a predominant enzyme form found in the skeletal muscles [71]. Another promising candidate gene for traits related to skeletal muscle metabolism in pigs is the glycogen synthase gene (GYS1), which encodes glycogen synthesis in skeletal muscles [72]. The mRNA levels of these two genes (HK2 and GYS1) were significantly higher in fast-glycolytic-type muscles than slow-oxidative-type pig muscles [73], and the expression level of GYS1 gene in pigs were significantly lower in pigs with a higher post-mortem pH1 and pH measured 24 hours after slaughter (pH24). In our study, we did not demonstrated any differences between wild boars and domestic pigs in the expression of these two enzymes at the mRNA level or any correlation between both pHs (pH1 and pH24) and the glycolytic enzymes genes expression [49]. We found minor positive correlations in the expression of genes for IIb MyHC and Gys1 (p = 0.0735), which is in accordance with a greater glycolytic potential of IIb myofibres.
Recent studies have also focused on the genes that are important for different lipid metabolic processes in myofibres. One of these genes is a peroxisome proliferator-activated receptor gamma coactivator 1 alfa (PGC-1α) that regulates downstream target genes and has a crucial role in myofibre metabolism and type maturation and can even induce the transformation of fast myofibres into the slow type [74]. In vitro evidence suggests that PGC-1α also plays a role in myoblast differentiation [75]. Additionally, other lipid metabolism-related genes have attracted research interest because of their potential association with meat quality, especially those involved in lipogenesis, fatty acid uptake and fatty acid oxidation [47, 48, 76].
The MyHC expression patterns observed in the wild boar and domestic pig were in agreement with the higher number of SDH-positive myofibres, and higher intra-myofibre lipid (IMFL) content (estimated by oil red O staining intensity) [49]. These data corroborate with previous studies reporting a positive correlation between the abundance of MyHC-I transcript and SDH activity [61] or the IMF content [47] and a negative correlation between MyHC-IIb and the IMF levels [77]. It can be assumed that the relative abundances of MyHCs are interdepended with the abundances of lipid metabolism-related genes. PGC-1α has a clear impact on metabolism via its effects on several downstream target genes that have an impact on lipid metabolism in pigs, as established by Erkens et al. [76]. Similarly, it was demonstrated that PGC-1α expression is higher in local Chinese pigs, together with higher MyHC–I, –IIa, and –IIx transcript levels, higher IMF levels, and superior meat quality than those of Landrace pigs [47, 48]. The PGC-1α level is higher during the early postnatal period in the wild boar than in the domestic white pig; however, the difference in expression between the breeds was not significant in adult pigs. The relative PGC-1α expression level diminished during the early postnatal weeks in both breeds, during which the myofibres underwent intensive contractile and metabolic specialisation. The level was maintained in the adult wild boar, whereas it increased after the first three weeks in the domestic pig. The latter observation can be explained by the finding that PGC-1α plays a role in the myoblast differentiation/maturation [75]. In addition, the mRNA expression levels of lipogenesis (e.g. peroxisome proliferator-activated receptor gamma, PPARγ)- and fatty acid uptake (e.g. lipoprotein lipase, LPL)-related genes were shown to be higher in local fatty pig breeds i.e. Rongchang breed in China compared to the commercial Landrace pigs, whereas the expression of the fatty acid oxidation-related gene (carnitine palmitoyltransferase-1B, CTP-1B) was higher in Landrace pigs [48]. We did not find any considerable differences in the mRNA expression of examined enzymes between the wild boar and domestic pigs of the same age; however, we did note a few age-related changes. This was rather unexpected, but it corroborated the results of Park et al. [62], who also provided evidence that energy metabolism and the contraction speed could be uncoupled in myofibres. To summarise, the metabolic features of pig skeletal muscle, SDH activity, and the oil red O IMFL staining intensity demonstrated a clear relationship with the contractile profile reflected by MyHC expression, whereas unexpectedly there is no correlation with the expression of genes involved in lipid uptake and utilisation.
7. Conclusion
To summarise, the comparison of growing domestic pig with wild ancestors of the same age show that domestication and breeding conditions lead to changes in the direction and intensity of postnatal MyHC transformation in pig longissimus muscles. In the domestic pig, the transformation of MyHC was shifted towards myofibres that expressed MyHC–IIb, which resulted in accelerated myofibre hypertrophy and protein accumulation with clear glycolytic metabolic properties of the muscle as a whole. In the wild boar, the maturation of the longissimus muscle is characterised by a faster elimination of developmental MyHC and differentiation towards oxidative and metabolic intermediate myofibres in which type I, IIa, and IIx MyHCs prevailed. The histochemical analysis of oxidative enzyme activity and intramyofibrilar fat content corroborates with the MyHC expression profile. However, the mRNA expression level of the studied genes involved in glycolysis, lipid uptake, and lipid utilisation did not differ between the wild and modern domestic pig breeds, suggesting that posttranscriptional modifications regulate the metabolic activity of these enzymes.
Acknowledgments
We acknowledge funding from the Slovenian Research Agency (program P4-0053). MV and GF also participate in project SuSI, co-financed by Susan EraNet and the Slovenian Ministry of Agriculture, Forestry and Food.
\n',keywords:"pig, myosin heavy chains, myofibre, immunohistochemistry, qPCR",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73672.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73672.xml",downloadPdfUrl:"/chapter/pdf-download/73672",previewPdfUrl:"/chapter/pdf-preview/73672",totalDownloads:158,totalViews:0,totalCrossrefCites:0,dateSubmitted:"June 23rd 2020",dateReviewed:"September 30th 2020",datePrePublished:"November 5th 2020",datePublished:null,dateFinished:"October 19th 2020",readingETA:"0",abstract:"The wild boar and modern highly selected pigs are phenotypically distant European pig breeds reared in contrasting conditions and present ideal model to better understand the mechanisms behind meat quality deterioration related to domestication and selection pressure, which provoked substantial modifications in the ontogenic development as well as contractile and metabolic properties of skeletal muscles. The skeletal muscle of domestic pigs are less mature at birth and contains a lower number of myofibres compared to wild boars; however, expansive myofibre hypertrophy, protein accretion as well as additional myofibre formation are accelerated in the early postnatal period in some muscles in domestic pigs. A comparative view of the cellular and subcellular mechanisms underlying the skeletal myofibre development could help to design a breeding program that would improve the balance between the growth performance, muscularity and meat quality. This chapter therefore outlines the influence of domestication on myofibre formation and differentiation during growth and provides a comparative view on the developmental expression pattern of the MyHC isoforms, the activity of different metabolic enzymes, and the expression of selected genes responsible for the metabolic diversity of the myofibres. Additionally, there is a special emphasis on the type, composition, and histomorphological traits of myofibres.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73672",risUrl:"/chapter/ris/73672",signatures:"Milka Vrecl, Jana Brankovič and Gregor Fazarinc",book:{id:"9714",type:"book",title:"Tracing the Domestic Pig",subtitle:null,fullTitle:"Tracing the Domestic Pig",slug:null,publishedDate:null,bookSignature:"Dr. Goran Kušec and Dr. Ivona Djurkin Kušec",coverURL:"https://cdn.intechopen.com/books/images_new/9714.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83962-692-0",printIsbn:"978-1-83962-691-3",pdfIsbn:"978-1-83962-693-7",isAvailableForWebshopOrdering:!0,editors:[{id:"292865",title:"Dr.",name:"Goran",middleName:null,surname:"Kušec",slug:"goran-kusec",fullName:"Goran Kušec"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Skeletal myofibre types, their classification, and characteristics",level:"1"},{id:"sec_3",title:"3. Proportion of different types of myofibres and their histomorphometric traits",level:"1"},{id:"sec_4",title:"4. Developmental pattern of myofibre type formation",level:"1"},{id:"sec_5",title:"5. Hyperplastic potential of pig muscles",level:"1"},{id:"sec_6",title:"6. Expression patterns of genes involved in myofibre metabolism",level:"1"},{id:"sec_7",title:"7. Conclusion",level:"1"},{id:"sec_8",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Teletchea F. (June 7th 2019). Animal Domestication: A Brief Overview, Animal Domestication, Fabrice Teletchea, IntechOpen, DOI: 10.5772/intechopen.86783. Available from: https://www.intechopen.com/books/animal-domestication/animal-domestication-a-brief-overview.'},{id:"B2",body:'Bywater K, Apollonio M, Cappai N, Stephens P. 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Developmental expression and 5′ end cDNA cloning of the porcine 2x and 2b myosin heavy chain genes. DNA and Cell Biology. 1997;16:1429-1437.'},{id:"B56",body:'Lefaucheur L, Ecolan P, Plantard L, Gueguen N. New insights into muscle fiber types in the pig. The Journal of Histochemistry and Cytochemistry. 2002;50:719-730.'},{id:"B57",body:'Lefaucheur L, Ecolan P, Lossec G, Gabillard JC, Butler-Browne GS, Herpin P. Influence of early postnatal cold exposure on myofiber maturation in pig skeletal muscle. Journal of Muscle Research and Cell Motility. 2001;22:439-452.'},{id:"B58",body:'Harrison AP, Rowlerson AM, Dauncey MJ. Selective regulation of myofiber differentiation by energy status during postnatal development. The American Journal of Physiology. 1996;270:R667-674.'},{id:"B59",body:'Berard J, Kalbe C, Losel D, Tuchscherer A, Rehfeldt C. Potential sources of early-postnatal increase in myofibre number in pig skeletal muscle. Histochemistry and Cell Biology. 2011;136:217-225.'},{id:"B60",body:'Mascarello F, Stecchini ML, Rowlerson A, Ballocchi E. Tertiary myotubes in postnatal growing pig muscle detected by their myosin isoform composition. Journal of Animal Science. 1992;70:1806-1813.'},{id:"B61",body:'Men XM, Deng B, Tao X, Qi KK, Xu ZW. Association Analysis of Myosin Heavy-chain Genes mRNA Transcription with the Corresponding Proteins Expression of Longissimus Muscle in Growing Pigs. Asian-Australasian Journal of Animal Sciences. 2016;29:457-463.'},{id:"B62",body:'Park SK, Gunawan AM, Scheffler TL, Grant AL, Gerrard DE. Myosin heavy chain isoform content and energy metabolism can be uncoupled in pig skeletal muscle. Journal of Animal Science. 2009;87:522-531.'},{id:"B63",body:'da Costa N, McGillivray C, Chang KC. Postnatal myosin heavy chain isoforms in prenatal porcine skeletal muscles: insights into temporal regulation. The Anatomical Record. 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Veterinary Faculty, Institute of Preclinical Sciences, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia
Veterinary Faculty, Institute of Preclinical Sciences, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia
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Research shows that state-of-the-art technology is such that care robots can become nonthreatening social entities and be accepted and appreciated by the lonesome. Massive employment of such devices is impeded, however, sufficient governmental support of R&D is lacking—financially and regulatorily. This is where policymakers should step in and get over their moral prejudices and those of their voters and stop being afraid of losing political backing. They will regain it in the long run.",book:{id:"6003",slug:"robotics-legal-ethical-and-socioeconomic-impacts",title:"Robotics",fullTitle:"Robotics - Legal, Ethical and Socioeconomic Impacts"},signatures:"Johan F. 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The attribution of liability for damages produced by autonomous agents usually focuses the theoretical discussion on legal and ethical fields on robotics. The European Parliament adopted the report with recommendations to the Commission on Civil Law Rules on Robotics (2015/2103(INL)) in February 2017. This work includes the master guidelines that the European Commission should take into account to legislate this technology. In its attempt to attribute responsibility for damages caused by robots, the Committee considers that once responsible parties have been identified, their liability level should range, looking the robot’s learning capability and the knowledge learned from its owner. This work proposes the use of responsibility setting matrix as a mechanism to distribute liabilities between the robot, the manufacturer, and the owner, depending on the knowledge programmed by the manufacturer and the one acquired by the robot (through its learning ability and the adjustments made by the owner), that would distribute the responsibility for damages among the three agents involved.",book:{id:"6003",slug:"robotics-legal-ethical-and-socioeconomic-impacts",title:"Robotics",fullTitle:"Robotics - Legal, Ethical and Socioeconomic Impacts"},signatures:"Alejandro Zornoza, José C. Moreno, José L. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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