\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"1475",leadTitle:null,fullTitle:"Aspects of Pacemakers - Functions and Interactions in Cardiac and Non-Cardiac Indications",title:"Aspects of Pacemakers",subtitle:"Functions and Interactions in Cardiac and Non-Cardiac Indications",reviewType:"peer-reviewed",abstract:'Outstanding steps forward were made in the last decades in terms of identification of endogenous pacemakers and the exploration of their controllability. New "artifical" devices were developed and are now able to do much more than solely pacemaking of the heart. In this book different aspects of pacemaker - functions and interactions, in various organ systems were examined. In addition, various areas of application and the potential side effects and complications of the devices were discussed.',isbn:null,printIsbn:"978-953-307-616-4",pdfIsbn:"978-953-51-6488-3",doi:"10.5772/845",price:119,priceEur:129,priceUsd:155,slug:"aspects-of-pacemakers-functions-and-interactions-in-cardiac-and-non-cardiac-indications",numberOfPages:208,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"c466df43e69f99f13186f22e9123b6a6",bookSignature:"Oliver Vonend and Siegfried Eckert",publishedDate:"September 15th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/1475.jpg",numberOfDownloads:28648,numberOfWosCitations:3,numberOfCrossrefCitations:4,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:12,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 3rd 2010",dateEndSecondStepPublish:"December 1st 2010",dateEndThirdStepPublish:"April 7th 2011",dateEndFourthStepPublish:"May 7th 2011",dateEndFifthStepPublish:"July 6th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"36038",title:"Dr.",name:"Oliver",middleName:null,surname:"Vonend",slug:"oliver-vonend",fullName:"Oliver Vonend",profilePictureURL:"https://mts.intechopen.com/storage/users/36038/images/1695_n.jpg",biography:"Born in Germany, he is currently an assistant professor of the department of Nephrology of the Heinrich-Heine-University Duesseldorf. Oliver Vonend was working in London, Baltimore and Boston concentrating on neuroscience and the sympathetic nervous system before he moved to the Ruhr-University Bochum. As a Junior-Professor he directed many doctoral theses in the he field of experimental nephrology. In 2008 he started his actual position in Duesseldorf. One of his major clinical fields of interest is the workup and treatment of resistant hypertension. He has various national and international publications in the areas of experimental and clinical hypertension. Besides the evaluation of secondary causes for hypertension he analyzes the efficiency of electrical baroreceptor stimulation and high frequency renal nerve ablation as new options for resistant hypertension.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Heinrich Heine University Düsseldorf",institutionURL:null,country:{name:"Germany"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"252244",title:"Dr.",name:"Siegfried",middleName:null,surname:"Eckert",slug:"siegfried-eckert",fullName:"Siegfried Eckert",profilePictureURL:"https://mts.intechopen.com/storage/users/252244/images/system/252244.jpg",biography:"Specialist in internal medicine / cardiology / angiology\nDiabetologist DDG / Hypertensiologist DHL / European Hypertension Specialist ESH /\nCardiovascular preventive medicine DGPR\nAdditional qualification Interventional Cardiology (DGK)\nAdditional qualification Interventional Therapy of the Peripheral Arteries and Pelvic Arteries (DGA / DGK)\nAdditional qualification Interventional Therapy of the Visceral and Renal Arteries (DGA / DGK)\n\nHead of Angiologiestellv. 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An MIS gathers data from multiple online systems, analyzes the information, and reports data useful for the management and the decision-making. The main goal of this book is to bring together leading academic scientists, researchers, and research scholars to exchange and share their experiences and research results on all aspects of Information systems. We also hope to provide a premier interdisciplinary platform for researchers, practitioners, and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions adopted in the fields of Information systems. This book is intended for Computer Science students, application developers, business professionals, and researchers who seek information on Information Systems.
\r\n\tWe hope to present dozens of algorithms and implementation examples, all in pseudo-code and suitable for use in real-world, large-scale Information Systems and their applications. We also hope to address advanced topics such as mining object-relational databases, spatial databases, multimedia databases, time-series databases, text databases, the World Wide Web, and applications in several fields. The goal is to provide a comprehensive, practical look at the concepts and techniques needed to get the most out of data.
Youth unemployment rates are much higher than adult rates in all regions, Isabel et al. [1]. According to the National Institute of Statistics, in Cameroon, youth unemployment is higher (6%) than that of the whole population (3.8%).The unemployment rate of youth has proven to be more sensitive to that of adults, supporting the “first-out, last-in” hypothesis. Youth face a longer recovery than adults, mainly because of surplus labour competing for a limited number of jobs, youth, with their shorter work histories, will also be the “last in”..
\nMany youth are stuck in work that does not match their skills level or desired career path, [2]. The high employment-to-population ratios of youth in the poorest regions reflect the fact that the poor must work more vulnerable to poverty and less vulnerable to unemployment. There is a correlation between lower unemployment rates and higher vulnerable employment rates. The lack of social safety nets such as unemployment benefits means the poor cannot afford to be unemployed. Instead, they struggle to earn an income through own-account work or sporadic casual wage employment. Most persons in developing economies do not have access to wage and salaried employment, where job losses occur, but rather make their living in self-employment (own-account work) or in contributing to family work.
\nAbout one third of economically active youth are unemployed. It affects a broad spectrum of socio-economic groups including the less and well-educated youth and especially youth from low-income background and those with limited education. According to the World Bank [3], in 2010 about 92% of young people employed were in the informal sector in Cameroon. Unemployment rate is not the best indicator for measuring crisis impact on young people. Majority of youth in Africa are engaged in informal sector activities. Only a small proportion is engaged in the formal sector. A large proportion of youth are thus under-employed, working long hours under poor working conditions for little remuneration mainly in the informal sector.
\nGlobal labour markets have also been increasingly characterized by vulnerable employment, which is strongly related to low-paying jobs and difficult working conditions where wage inequality is high and fundamental worker’s rights are likely to be in jeopardy. Vulnerable jobs and informal work can be expected to be widespread. According to the National Institute of Statistics [4, 5], in Cameroon, underemployment was about 12.3% in 2010, it was 12.1% in 2005.
\nIncreasing “labour precarization” is fast becoming a concern. The “precariat” is a class in the making, a growing number of people across the world live and work precariously, usually in a series of short-term jobs, without recourse to stable occupational identities, social protection or protective regulations relevant to them. They are increasingly frustrated and dangerous because they have no voice, and, hence, they are vulnerable to the calls of extreme political parties [1].
\nWorking poverty affects workers of all ages, vulnerability increases at different stages of the life cycle. Youth, in particular, have a higher likelihood of being among the working poor than adults [6]. Large cohorts of poor youth remain trapped in low-productivity jobs, principally in subsistence agriculture. Out of economic necessity, their offspring are, in turn, likely to enter the labour force at an early age, perpetuating the vicious circle of poverty from one generation to the next [3, 6].
\nWorkers who experience unemployment, especially of long duration, have an increased likelihood of being jobless in later years and earning lower wages. These effects, which are known as “wage scars,” are observed in both young and adult populations, but the evidence overwhelmingly shows that the impacts are much more acute on young workers [7].
\nA widespread coping strategy linked to the jobs crisis has been selling household assets and borrowing money. In order to maintain consumption needs during periods of unemployment or reduced or erratic wages, many households have drawn down savings and sold possessions, as well as turned to friends, relatives, membership-based clubs, community groups and banks, where possible, for financial help. While selling assets and borrowing are, indeed, important safety nets for the poor, they are also easily exhaustible [1].
\nWhat strategies do the poor youth of Douala adopt to survive in an urban area like Douala where the rate of unemployment, underemployment and own-account workers is very high and especially where everything is monetized?
\nThe main objective of this work is to elicit all the coping mechanisms that the poor youth use to continue living with inadequate income in Douala.
\nThe questionnaire construction was based on the notion that poverty is relative to a society and epoch. Sociologically speaking, one is poor when one cannot attain the values of one’s society. That is, a sociological description of poverty must take into consideration the values of the society in question. These values are not to be prescribed by the researcher in order to avoid subjectivity. The value must be a general consensus of those living in the society in question at the time of the research, [8].
\nWe carried a pilot studies which is a small scale preliminary study conducted before the main research to find out the psychological and social essentials for ordinary living patterns in Douala in order to improve the design of the research. We asked respondents what they considered to be normal social activities; that is, the psychological and social essentials for ordinary living patterns in Douala. It was administered on 30 respondents having varied social status and then the responses constituted the foundation of our questionnaire.
\nWe used the mixed methods research because the combination of quantitative and qualitative approaches provides a more complete understanding of a research problem than either approach alone [9, 10]. The quantitative methods helped us to establish the poverty-line and the qualitative method helped us to understand the daily struggles for survival of the poor youth of Douala. A blend of both the quantitative and qualitative methods provided a profound picture of what youth poverty is in the city of Douala. The overall intent of this design is to have the qualitative data explain in more details the initial quantitative results.
\nWe used the random sampling method wherein we selected every fifth of the youths in Douala ensuring that everyone had an equal chance in the selection. It is worth-noting that we had a full grasp of the sampling frame. We went to all the sub-divisions and all the neighbourhoods in each division.
\nThe number of questionnaires administered in each of the five sub-divisions was determined by its population. We put the population of each sub-division over the total population of the five sub-divisions and then we multiplied by our sample size 610. We ensured that the number of females or males in the study was equivalent to their percentage in the general population by using the same above mathematical application.
\nWe tried as much as possible too to ensure that the percentage of each sex selected was almost same as its percentage in the general population. In Douala, there are 956,883(49.67%) females and 969,630(50.33) males out of the total population of 1,926,513. Equally, we selected 300(49.18%) females and 310 (50.82%) males out of the total sample size of 610.
\nYouth age difference and poverty-line in Douala. | \n||
---|---|---|
Age range | \n% Below poverty-line | \n% Above poverty-line | \n
‹21 | \n95 | \n5 | \n
21–25 | \n95.3 | \n4.7 | \n
26–30 | \n90.2 | \n9.8 | \n
31–35 | \n84.5 | \n14.5 | \n
The above table shows that as age increases, the number of persons below the poverty-line decreases and vice versa. The graph below shows the distribution of income among the youth in the city of Douala.
\n\n
From the above it is glaring that that a bulk of the youth in the city of Douala earn between 24,000 and 74,000 frs CFA (41%), 4.8% earn below 24, 000 frs and 19% earn nothing. Only 9% of the youths in Douala earn about 177,000 frs and above which is the amount required for participating in the predominant values in Douala [11, 12, 13]. It is quite difficult to cope in the city of Douala using such low salaries. Therefore the youths in Douala are what ILO [2] describes as the working poor who live below the poverty line and are working out of economic necessity. According to it, youth, in particular, have a higher likelihood of being among the working poor than adults. The question that preoccupies us in this work is the coping mechanisms these working poor youth in the city of Douala use to survive. In other words, what strategies do they use to have a good feeding habit, domestic comfort, health seeking behaviour among others?
\n\n
The above histogram indicates that 26.6%, 44.7%, 17.4%, 1.3%, 1.5%, 4.3%, 4.2% of the youth in the city of Douala diversify their activities, work for long hours, are dependent, are prostitute, thieves, gamble and do others things respectively to survive. Therefore to survive in the city of Douala, the poor residents work for very long hours because they do a diversity of activities to survive.
\nThe poor youth of Douala do many precarious economic activities. When in financial difficulties, they walked out of their zone of expertise and do many other activities whether related to their field of specialization or not. So for the poor youth in Douala to survive, they must be very smart and tactful. They must learn to do several jobs simultaneously and must be willing to sacrifice their resting time to check their private work because it is what relieves them when their masters fail to pay their salaries for months and equally helps them to solve their other problems. As such, they overwork themselves just to survive since they do not have any support network either from their government nor parents because they are either predominantly from a polygamous family, or have lost a parent, or their parents are simply irresponsible or too old or too poor to take care of them. They have to fight on their own while hoping that their future will be better.
\nSerge who is mechanic lived alone and was independent because his former master had sent him away. Therefore he had to struggle as much as possible to survive in life. He had worked 2000 frs CFA the day we met him which was enough only for saving in the meeting he attended. So he had to do something different as he said “I will struggle elsewhere to live” meaning he was going to do other things to survive which was to change the tyres of vehicles which was not initially his profession.
\nMathias a mechanic who did not have enough money to pay his rent, buy dresses, food for himself and take care of his younger ones, had to do other jobs related to his profession such as repairing motorcycle, light panel beating just to survive and help family members.
\nFor a poor youth to survive in Douala, he/she must be very calculative—that is, must try as much as possible to make good use of the little resources that he/she earns as well as do many other things to complement his or her salary. This is the case of Nora who operated a call-box business in Bonanjo—she ensured to save 7000 francs weekly every week-end for her “Pépé-soup business” from which she gained 2000 francs per day which she would use to feed her two children and her unemployed husband. She would give 1000 francs to her husband to prepare food in the house and would add the remaining 3000 to the 7000 francs to buy air-time credit for her call box business.
\nAlain who earned about 100,000 frs CFA thinks it was insufficient to carter for all his needs and those of his relations. Apart from being employed as a commercial agent he also worked in the informal sector: he had an unlegalised printing press. He was afraid his master would dismiss him if he legalized it in his name. He was doing everything possible to use the names of one of his cousins in order to maintain his job. Whenever he presented the goods of his company, he would tell his customers about his printing press and the services they offer. They would call him whenever they needed his services which he would give to workers he had employed to work in the printing press. He would check it in the evening or during break-time or after returning from his work or over the weekend. He was also a go-between: he was a commercial agent, his customers would call for him to advertise their products which he would sell at an elevated price in order to make some gains for himself. He looked for them too even during working hours.
\nRomeo who wanted to go back to the university, sold umbrella, schoolbags and others goods over the week-end and even on Sunday in Bonanjo which is normally a resting day in order to make more money for himself. “I am a fighter because I can do all to survive” he had difficult moments but he tried to overcome them in one way or the other.
\nPoor youth who are teachers did what Bissai, a secondary school teacher symbolically termed to be “prostitution by giving home tuition to rich people’s children,” for payment. At times their masters would stay for months without paying them but they had no choice but to keep on teaching their children. Bissai equally had a plantation in his village although he did not have enough money to invest in it.
\nMost poor youths are very flexible and creative in doing businesses and other activities. When one business is not doing well, they can easily switch to another or do another activity. They equally serve as some sort of reserve labourers for building site; whenever someone has a contract to build a house for example they would employ them and pay them per task or at the end of the day. From the beginning they would give building materials to the builders, later they mix the mould and then learn how to build and even lay the bricks. After having mastered the work, contractors take building contracts and hand them over to them and pay them very low-salary since they do not know the value of work not being professionals themselves.
\nAn interesting example is Djeufack who dropped out of school from lower sixth. He is a builder, a painter, a welder and an electrician, etc. He learned all that except electricity “on the spot” he said, that is in the course of doing them without any formal training. If a contractor goes to the quarter looking for a painter for example, they pretend to be painters just because they are idle and poor. The contractor takes them to the construction site. “We pretend to give him the different types of paints and materials that we need and will go and ask the price from a quincaillerie.” This is just for them to get better information from a professional painter whom they will take to the site. After having all the required information, they then return and bargain with the contractor before starting the work. If from the onset the work is not going on smoothly, they will call an expert who will show them how to do it. The expert comes and verifies the work at the end to ensure that they have done it very well.
\nSometimes they recruit them and they learn from those who know how to do it already although they all earn the same salary. It is difficult for the contractor to distinguish experts from charlatans. At times those who master the work report them to the contractor and if he notices that the work has been well done, he does not care to punish them. They understand very fast when those who have a mastery of the work teach them on the spot. Although he said such works “suffocate a lot and is dirty” and it is not motivating but “we have no choice because we need it,” said Djeufack.
\nDjeufack who learned electricity at school, would take those idling in the quarter to help him whenever he had a lot of work to do. When he was employed as storekeeper in COMENTAL, he learned welding too on the spot during his free time because they were welders around him. Some of his friends who had welding jobs out of the company gave them to him and he did the works during his free time.
\nThey also do farm work not because they have done it before but because hardship forces them to accept it. They ask farm proprietors who have farms to hire their service. They dump them there just to come back in a week to pick them up. They cut grass and harvest crops. There is no sense of direction when they are working because they have not done it before.
\nDjeufack also did small business that is, all what he could find: he sold apparatus, motorcycles, etc. He was a go-between if someone wanted to buy or sell something; he communicated it to those who are in need. If he sold it above the cost price, the extra sum will be his gain. He also did the business his dead father left because he did not have any other thing to do at the moment we met him—meaning that at the time we met him if he had had something more fruitful to do, he would have left for it. He was also a caterer because his brother was involved in it and constantly would call for him.
\nHowever, Djeufack has got no precise job, just like many other poor youths in the city Douala he does whatever he sees—he is an electrician, a welder, a go between, a painter, and does tapestry when there is an opportunity for him to do caterer, business, clearing people’s farm he would not hesitate accepting them.
\n“Why all this?”, we asked him.
\n“Because it is not working,” he replied.
\n“Why?” We asked again.
\n“The country is not well, we are obliged to juggle like this to survive—because all is expensive and work is rare and it is by knowing someone. It is necessary to fight to have something,” he replied.
\nThe salary is not good all the times but they are obliged to do it because they have got nothing else to do. However it is very competitive because there are many other poor youths in need of them. One could arrive when they had called for other persons.
\nModelling is learning by imitating others. When we learn how to behave in a new situation by watching how other behave in other words called observational learning. An example is watching someone use unfamiliar tool either live or on film and afterward being able to handle the tool oneself [14].
\nThis is the method that many youths in Douala use to survive. They do not wait to have a proper training in something before doing it. They are daring and very adaptive and some learn very fast on the spot. After all they have no choice, imagine you have stayed for days without eating what will you do when an opportunity comes your way for you to earn some money? Will you refuse it because you have not got the appropriate training? So they have to “juggle to survive.” It gives us a sense of disorder but which saves its purpose.
\nThere is no verification of expertise in such work—painting, welding, clearing a farm repairing a benskin, etc. We see the poor youths of Douala as being creative, someone trying to make maximum use of his environment and not just someone who just sit and hope that things may change on its own. He works while hoping. By so doing they later become professionals in many other fields that they have received no formal education or training. Tchuigoua summarized as follows: “All what I see that I can do, I do it.” They are not out to select jobs after all the jobs are very rare and highly solicited—that is, the poor youths scramble for them. If you are selective you will stay for weeks and even months without doing anything. In short, you will starve to dead. How then will you manage your bills, feeding, dressing, and other things?
\nWhenever the youth are pushed against the wall, they often forget their identity: their level of education in order to satisfy their basic needs. They cannot brandish their certificates because it cannot put food on their plates. Although it is often frustrating but they have got no choice-they have to accept it or suffer the worst pains of poverty.
\nAnne is a 30 year old unemployed single lady who has a professional degree in touristic industries management and whose parents have been helping her for long. She said “my parents are very tired financially.” Having changed her jobs four times because of too much work and little salary which could not help her to save, she decided to do what she called “small work” such as placing “grafts,” plaiting women’s hair at their homes. She earned about 74000 frs CFA which was not enough to satisfy her basic needs and her objectives in life of returning to school.
\nBernard was a BTS holder from the Institute Universitaire de Technologie of Douala who worked as an electrician in a construction site in Makepe. Although he earned about 4000 frs CFA per day, he considered his salary “disappointing, derisory. It cannot even be enough considering the size of the company.” According to him, it did not permit him to express his intrinsic values—that is, it is lower than his qualification. According to him, he ought to study the system, control and conserve it but as he put it “I only execute.” It disturbs him because he cannot express what he wanted to do by anticipating but only have to follow “the dictatorship of the enterprise.” He did not have any job satisfaction and was looking for a job that suited his level.
\nThis means empowering ones wife by enabling her to operate a small business which can increase the household income rather than depending only on the man. According to Aert et al. [15], the inactivity of women is only possible when the other members of the household bring enough resources for the up-keep of the family. In a situation of insufficient resources, women contribute to the house comfort by working in the informal sector: doing petty business or operating a call box business.
\nRomeo who earned about 90000 frs CFA per month considered it insufficient to pay rent, bills and feed his family. To ameliorate his household comfort, he opened a shop for his wife where she sold Chinese sandals. He would invest about 7000 frs CFA every week in her business which help her to buy more food for the household. She saved 5000 frs CFA every week in a meeting in order to increase the size of her shop. Romeo had four trucks on rent managed by his wife which yielded her 1200 frs CFA per day which she would use to buy her personal and household needs such as detergents and their child’s needs, etc. They made a lot of sacrifices by eating twice rather than thrice in order to invest more money in their business.
\nEqually at times too Romeo like many other petit traders would sell their goods at a loss in order not to fail their contribution or to give food money at home. They are bound to do this because such gatherings do not have pity on the poor. Failure to contribute is often sanctioned by a fine. That is the little the poor has is further extorted by the association which will be later shared as accrued interest at the end of the year or session. Therefore the poor who join such associations do everything even to their own detriment to have their
They are also conscious of the fact that they equally have to feed their family and will do everything possible to have money for food. “What will you tell a child when he is hungry; it means you have failed as a father,” said Romeo—so they are conscious of their parental role. This is an indication that the poor youths have not develop the culture of poverty because they are conscious of the mainstream value of handwork which they think could bring them success. They are very hard working because they believe or are convince that they will make it 1 day in life. The question is whether they can develop the culture of poverty if failure comes after continuous struggles to survive—the sign of learned helplessness.
\nSome despite their slow-paced business do not have any other activity that they could do to earn extra money because they have just started. Some said if their business declined, they would be obliged to be motor-taxi drivers in the evening—they would rent it because they did not have enough money to buy one. Similarly Ayissi was raising money for her husband to start an ambulant second-hand shoes business. It was quite a reversal of role for the woman to be the one fighting for the man and not the reversal.
\nSince the amount the poor make from their business is so insufficient, they borrow from friends to buy their goods such as cigarettes, biscuit, air-time credits, chips, bonbons, cool water, etc. to retail them. If it happens that they have not got the money yet and their creditors want the money, they will borrow from another friend to pay the creditor and the chain continues until they have made some profits from their business to pay back. Survival for the poor is really an uphill task and a lot of risk-taking. They keep on juggling while hoping that 1 day they will make enough money in order not to take credit but it is often difficult because the amount they gain from their business is often very little as compared to the problems they have to solve: paying children’s school fees, feeding them and even taking care of them. At times some of the women even use their business capital to feed the family because their husbands are not working. What a reversal of role!
\nAbout 10% of friends live together in order to save money by jointly paying their rents. They share the bills together and help each other whenever one of them is hard-up. When one is agonized, the other put a smile on his face by telling him stories—he helps to communicate with him thereby breaking the silence. He shares his problems with him and gets his advice. However, others consider living with an unemployed friend a disadvantage because they pay the bills alone. Their friends may lack the means although he may work as a petit trader in the market or do other petit jobs. Most often they do not have any choice because they have taken the decision to live with them. Mathias did not initially want to live with his friend because he wanted a quiet life to read the Bible and understand it due to his low education. His friend distracted him but he could not send him away. He prayed that God should provide his friend the means to rent his own room. He said things were always in disorder—he did not care about the house. Mathias did everything alone. His friend did not do the washing up. Living with him was not helpful to him—it instead brought him down. He hardly would switch off the television and hardly closed the door allowing rats to enter the house. Whenever he told him he thought he hated him. His friend did not care because he did not pay the bills.
\nMany things disturb the youths of Douala because they have limited resources to satisfy their needs. We asked them what they have done or were doing to solve them and their answers vary from total resignation to their fate to some actions taken to ameliorate their situation. The fact is that if they were more prosperous, they would solve their problems and as a consequence liberate themselves from psychological tortures.
\nSeigni was doing nothing to solve his psychological problems except his mechanic work where he was making maximum effort to succeed. He concluded by saying “what will I do?” Tchuigoua did not allow himself to be disturbed psychologically because of lack of means. “I am happy with my situation and I live with it. What ought I have done? Go and steal? I don’t have any choice ---I am obliged to accept. After the death of my father, I have understood that life is not easy … I am happy with my situation. I cannot go and break a bank because I need money.” Djonfack added that he was disturbed because his activity was stagnant and he needed to survive. He said “What will I do? I have not yet undertaken a solution.” Nineteen years old Kamdem did not diversify his activity to make money and did not often have enough money to live on, he said “Whether money suffices or not I am already used to it, if I have my two hundred francs, it is enough for me.”
\nMbengate on his part said “in my life when some problems confront me—I have the means to solve. I will solve and if I do not have the means I will stay because I am tired of begging.” Michou added that “I struggle with what I have” which still means he does not have any option and cannot expect more than he can afford. Therefore he put the little he had in maximum use. Without any other option, the 27 years old Northerner said “At certain month, I don’t have money. I just have to work. I can’t go and borrow money from people. At a given time I took 10 000 frs CFA and pay back 16 000 frs CFA from a brother.” However, Mokoro said “it just worries me and I have to borrow money from friends to meet-up.” Twenty-eight years old Romeo put it as such “What does not kill us make us stronger.” He is in a way valorizing poverty—since poverty cannot kill them it instead empowers them. He concluded by saying “I am mentally very strong—if I had not been psychologically strong, I would have fallen in the River Wouri.” He accepted his situation which was full of battles since his childhood and acknowledged that he was already used to it—some sort of overcoming it and is no longer afraid of it although his daily battle for survival was still a very tough one.
\nAnother category of youths are very combative. They do not want to accept their situation. “I say to myself, I must do all to change my situation,” Herman added by saying “ I am a struggler—I can do all to survive.” He always had difficult periods in his life and had always tried to overcome them in one way or the other.” “I must work,” Doumbé confirmed “I have struggled as I could.” This means he did not give in to psychological torment; he went out there and worked as much as he could. He acknowledged that “When I am in need, I put all in the hands of God.” Mathew too confirmed that work alone was insufficient “I always struggle to resolve my problems. I always ask God and He always answers my prayers.” Ngantchieu too said “I try to multiply the sources of revenue to pray to God that He gives me His grace and that find a good job.”
\nAlain solved his psychological problems by trying to have more money and to have jobs elsewhere. They even revolted at their place of work to force their master pay their 4 months arrears. According to Bissai the 31 years Old Catholic secondary school teacher, he permanently made sacrifices; revisited his management skills by economizing in order to manage spontaneous problems. “I am foresighted,” he concluded in the same light. Nora ensured to pay her rent and on time. She informed her debtors before time that she may not pay them on time in order to avoid problem with them.
\nEqually 26 years old Thierry who was a teacher said that students disrespected him and he would feel useless in front of them and as a result decided to be very hard on them and not to smile with them. One of our respondents decided to ameliorate his social relation by often visiting his friends and relations in order to communicate with them. Others are struggling not to miss death celebration which they do not often attend because of lack of means.
\nOthers manage their psychological problems by being violent Mathias put it as follows: “I do that because I think if I don’t react they may walk over me because they always want me to fulfil their plan first and not mine. I will become angry and will speak rudely and maybe someone will come out from them and say that I should stop. Whenever I speak they will hala only at that moment and stop, realizing that I also have right somewhere. I have tried many ways not to be hard but they always try to provoke me. I have prayed God not to speak to them hardly but I have noticed that when I speak to them hard they cool down their temper.” How frustrating it is for these poor youths with limited resources, who are unable to take care of themselves and whose family members are also pressuring them for help. In order to make them understand their hardship, they tend to be hard on them.
\nBernard is also trying to “reactivate” himself, hoping and searching because he believes in the adage which states that, “if you search without finding, you will find without searching.” He said he is not lazy and he has hope. In a way, one should keep on working hard for one will not go empty handed, one will end up finding something. What optimism!
\nMost of the female folks receive help from friends and family members. This indicates women’s dependence on others unlike their male counterparts who resign to their fate although they do not give up working.
\nOne of the questions we asked our respondents is what they were doing to better feed themselves considering that they were poor and could not feed themselves appropriately. We still repeat some of them for clarity sake and to better perceive and analyse it. There are four categories of poor youths: those who try to vary their meals, those who make an effort to consume fruits, those who cannot determine their feeding habits because of lack of means and those who think they feed themselves very well.
\nNgantchieu said “I try to vary meals—to consume fruits.” “I vary meals” Ngo Hiol confirmed “I balance my meals,” Pierre added. Romeo explained this further by saying “I try to vary my nutrition but it is not of the best quality since it is cheap in the market—it is the second class and not the first quality. For example good tomatoes cost more than cheap tomatoes but because of lack of means one is contented with the rotten ones.”
\nHowever, taking a variety of meals does not necessarily mean that one feeds very well because they may be of very bad quality as Romeo put it or the same class of food. Since the poor eat to fill their stomach, they mostly eat carbohydrates and hardly will they take protein and vitamin because they are expensive. Only 15% of the respondents said they vary their meals.
\nAbout 19% will take the substitute of meat and fish which are the source of protein. Nasser said “I buy cheap food like beans which replaces meat” A good number will take soya beans. Ouembe said he tried to ameliorate his feeding by consuming fruits. Alain confirmed this by saying “from time to time one buys fruits.” The 8% of respondents who take fruits buy them from the roadside for about 100 francs or so and as Alain put it, it was not consistent and heavy.
\nAbout 15% are very calculative in the number of meals they eat considering that they do not have enough resources and the next day meal is a mystery. As a result they have to make sacrifices in order not to stay hungry. This is neatly put by Calem by saying “I cannot go out of the house knowing that I am going to work, one juggles. If I eat a lot tomorrow what will I do. I eat on calculation much reflection before eating.” Their eating habit is determined by the amount of money they have worked that day. If it is good they eat vegetables too if it is not they go without and even spent days without eating. They do not have a fix eating calendar.
\nNora said she eats one type of food for about two to 3 days. “I can’t use food for three days in one day. How can I buy pufpuf for 300 frs CFA whereas I can use the three hundred francs to buy three cups of rice to feed the whole family for the whole day?” The problem here is not trying to ameliorate one’s feeding habit but trying to avoid hunger. This category of respondents do not have enough to feed themselves with, even their daily meals are uncertain so they ensure that the little resources that they have are well-used in order to avoid hunger the next day.
\nAlthough Mathias is planning to better feed himself he considers other things more important, he said he can sacrifice feeding in order to buy a phone. Bissai said he sacrifices money or send money to the village so that they can buy him food there because they are natural and cheaper. Some make an effort to eat a good meal “I am happy with a good meal once a week.” Others careless of whatever thing they eat Mathew put it thus: “It is necessary to have money. If I eat banana nobody will disturb at the end of the month.” Those who are living in a family house do not know whether they feed themselves very well or not because they eat only what is eaten—what is available.
\nMbengate said he did not feed himself very well because he did not eat what he liked. He ate what he saw or what he could afford with the little money he had. He was not making any plan to better feed himself because his system was already adapted to his type of food so it did not disturb him. Kamdem said he ate whatever pleased himself according to the amount of money he had. Therefore he was contented with his feeding habit. Those who said they fed very well said so according to their standard meaning that there is another standard which they cannot attain. Some sort of resignation to their situation. Serge thought he worked very hard to feed himself and Tcheugoua ate a heavy breakfast everyday at home and tried elsewhere during the day.
\nYouth poverty is situational and not cultural because they also wish to integrate the main stream values of their society but they are constrained—They equally wish to live like others and are making efforts either by economizing money or are saving in the course of their daily struggles. We can put them in two categories those who are already making an effort and those who are dreaming about it.
\nAs concerning owing a home about 34% are thinking of making an enormous sacrifice in the future to own a home that was why Oumbe called it a long term project because they did not have enough money to become a homeowner. They could not have them then because the little money they had was for their daily needs even if they bought them, they would have problems paying the bills. Nora further added that what was necessary at the moment was to feed herself, educate her children and she would only own a home if her life changed. She considered it a far-fetched project because she was making no effort.
\nSo, those who are not working do not dream of owning neither a home nor any durable goods. Those who are living with their parents especially female youth do not have the project of renting but to either buy or build a house because they are at ease at their family house and nothing is pushing them to leave. After all they do not have enough resources to rent. Although they do not have any short term project to own a home, they neither do not have projects to buy some durable goods because their houses are small and they lack the resources. That is why Mathew said “It is enough for me on rentage like this.” He meant that the things that he had were sufficient for him so far as he continued renting. So what he had was sufficient for him not because he did not want to have more but because they cannot do otherwise.
\nThe others are making desperate efforts to be homeowners and it is common to hear them say: “I am struggling as I can,” “I try to keep some money aside or to economize,” “I economize but it is not easy for I often lack to keep aside,” “I work in order to economize,” “I work a lot and I try to save,” “I put them in future projects,” I am saving now to be a home owner. It needs a lot of money so I will take more time to have. I will have to; it is not always good to copy from others.” “Saving from time to time even when problems come and ravage all.” “What disturbs me the more is to have my own house. It is a real problem more than having other goods,” “we struggle to economize.”
\nThe above are good testimonies of desperate youths who are making effort to be like others they see in the city of Douala—homeowners with homes full of durable goods. They also dream and as a result are working very hard to change their fate. Serge says “I am thinking of buying a land. I know that one day God will give me.” What a sign of hope. It is such a hope that forces them to work harder especially the Bamileke youths. Some are just let by the wind without any sense of direction. Some are saving money quite alright but building a house is a difficult task, that is, they do not have any precise idea of building a house. Tchuigoue said “I live with it like that.” The
It is true that the poor suffer from low-income because they are unable to provide for their needs but they are not unwilling to provide adequately for their own well-being as the individualist theory states. If the youth of Douala were lazy, they would not be working so hard to change their fate. This theory erroneously states that neither the society nor the social groups to which individuals belong are accountable, and therefore should not help the poor. This is wrong because the poor youths in the city of Douala are victims of circumstances. They did not choose to be born in the third generation of a polygamous family, nor poor monogamous families which failed to empower them socially and economically, nor in the region or harsh area where they were born.
\nThey are not lazy as such: a good number of them are quite hard working to change their lot. They are very hard working and creative; that is the reason why they diversify their activities in the informal sector and take advantage of every least opportunity that comes their way to make some money for themselves. This theory also states that, by increasing public expenditures they take money away from investment in industry and thus hinder the production of wealth. This is not the case with Douala where public investment and job creation is very low. Most of this youth would not have suffered from chronic poverty if the government had invested in the productive sector that could help employ them. Therefore the individualistic theory is not an appropriate theory that can be used to explain youth poverty in the city of Douala. Youth poverty is more a characteristic of a social group: a family or a community and not a characteristic of individuals.
\nThe youth in the city of Douala go about their everyday activities interpreting the harsh world in which they live. Their symbolic environment mediates the physical environment so that they do not only experience a stimulus, but rather a definition of the situation. A definition of the situation is the interpretation or meaning we give to our immediate circumstances. Berger states that a person finds out who he is as he learns what society is ([16], p. 78). According to Zenden facts do not have an inherent or uniform existence apart from the person who observes and assigns meanings to them. Real fact is the ways people define various situations. The youths of Douala form various identities in the course of struggling to survive.
\nFirst of all they acknowledge the fact that they live in a very difficult environment where the prizes of basic goods are very high and at the same time most of them are low-salary earners. More so, they are school drop outs, or have just halted their education in order to save some money that they are even unable to raise because their salary and the little profit they make from their petit businesses is used to satisfy their immediate needs. Their families have abandoned them to their fate because they are not the only children or because they are too poor to take care of their children. They therefore have formed various concepts about who they are, what sociologists call the self which emerges in the course of interacting with other people.
\nThe concept they have of themselves is one of the strugglers who is fighting to break the iron bars of poverty which is independent of their will, because they did not choose their family nor the order of their birth, they are just victims. There is nobody neither from their family nor the society in which they live ready to reinforce their capital building. Instead they are being exploited by those who have the least opportunity to do so. Therefore they must have the stamina to look for a way to survive. They often say: “I am a struggler because I can do all to survive.” They have difficulties in getting the required satisfaction however, they must live by creating other means the society may consider illegal. They deceive the vigilance of the gatekeepers those who restrict them from getting certain favours, in entering in certain neighbourhoods, etc.
\nThe concept they have of themselves is that of helplessness in getting the mainstream values of their society. Just like any other person in their society they will also like to be homeowners and own durable goods but they do not have the means. They seem resigned to their fate as they see their fellow friends and countrymen of their generation possessing what to them is far-fetched “It is difficult, one juggles only to live. What will I do?” “I am happy with my situation and I live with it, what ought I have done, go and steal? I do not have choice. One cannot do things that other people do, one is oblige to accept.” “What will I do, we know already that there is nothing,” etc.
\nThe third is that of uncertainty. Their future is very blur; there is no clarity of what will happen the next day. As a result they have to be cautious because if the worst comes to the worst, their poor parents nor the government will not be able to help them neither will they go to the tontines which exploit them by giving them loan on interest basis. “I cannot go out of the house knowing that I will work—one juggles. If I eat a lot tomorrow what will I do?”
\nThus with low educational level they define themselves as underachievers because they think they do not have the necessary academic backing them to pursue higher studies. Ayissi said “For my level what type of job can I have where I no get book. My job is equivalent to my level, I don’t expect more.” Alain meets people who can help him have a better employment but he has is not even a
After struggling to live by managing the little resources that they have, they may alienate themselves from what obtains in the outer world. They are always spontaneously awkward when they come in contact with it. Some confuse breakfast and lunch because they are not used to it not because they do not want it but because they do not have the means to have one. They are so used to not taking breakfast so much so that it has lost its importance. To them the perception of a meal is different from that of the rich. All what they care for is to fill their stomach and not to take light meal for taking sake.
\nThe poor youth of Douala do many precarious economic activities. When in financial difficulties, they walked out of their zone of expertise and do many other activities whether related to their field of specialization or not. So for them to survive, they must be very smart and tactful, flexible and creative in diversifying their businesses and other activities. When one business is not doing well, they can easily switch to another or do another activity. They do not wait to have a proper training in something before doing it. They are daring and very adaptive and some learn very fast on the spot because they have no choice. It is some sort of disorder but it saves its purpose. Men also diversify by empowering their wives to operate small businesses which increase the household income.
\nSurvival for the poor is really an uphill task and a lot of risk-taking. They keep on juggling while hoping that 1 day they will make enough money in order not to take credit but it is often difficult because the amount they gain from their business is often very little as compared to the problems they have to solve: therefore they engage in long-linked borrowing.
\nMany things disturb them because they have limited resources to satisfy their needs. Their solution is that of total resignation to their fate although they take some actions to ameliorate their situations. The fact is that if they were more prosperous, they would solve their problems and as a consequence liberate themselves from psychological tortures.
\nPoor youth try to vary their meals, some make an effort to consume fruits while others cannot determine their feeding habits because of lack of means. Their eating habit is influenced by the amount of money they earn daily. If it is good they eat vegetables too if it is not they go without and even spent days without eating. They do not have a fix eating calendar. Those who said they feed very well said so according to their standard meaning that there is another standard which they cannot attain. Some sort of resignation to their situation.
\nIn the course of struggling for survival, they form various identities of themselves: those of strugglers, helplessness, uncertainty, underachievers, alienated people, etc. Youth poverty is situational and not cultural because they also wish to integrate the main stream values of their society but they are constrained—they equally wish to live like others and are making efforts to save in the course of their daily struggles.
\nThe purinergic signaling modulates pathways of both neural and non-neural physiological processes, including immune responses, inflammation, pain, platelet aggregation, endothelium-mediated vasodilation, proliferation, and cell death [1]. Three main components are part of the system. Purinergic: extracellular nucleotides and nucleosides, their receptors, and the ectoenzymes responsible for regulating the levels of these molecules [2]. In addition, nucleotides, nucleosides, and uric acid resulting from the death of infected or injured cells are also recognized by other receptors better known for their role in pathogen recognition as Toll-like receptors (TLRs), and NOD-like receptors (NLRs) [3]. Other immune innate receptors are able to detect nucleic acids (RNA or DNA) from either phagocyted or circulating microbes, including retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), the C-type lectin receptors (CLRs), and cytosolic sensors [4, 5]. All immune cells are able to recognize nucleotides as a danger signal throughout either purinergic or no purinergic receptors. Immediately various immune responses can be activated, such as pro-inflammatory cytokines secretion by macrophages, quimocine production by eosinophils, maturation of dendritic cells (DCs), as well as T and B cells costimulation [6].
Extracellular nucleotides and nucleosides are released, along with many other molecules, from dead cells. Apoptosis and necrosis are the cell death mechanisms that can operate in physiological conditions. Apoptosis is activated by genetically controlled cell signals to modulate cell growth and development, as it is a programmed event. It is an ordered process that does not trigger inflammation. Conversely, necrosis is a not regulated cell death, characterized by the cell content release as a consequence of the effect of diverse environmental factors, leading to higher inflammation around [7]. Furthermore, during infections, some intracellular pathogens require cell lysis, while others have developed mechanisms to prevent cell death during their replication and dissemination outside the infected cell.
ATP is known as a damage signal, released or leaked by injured cells, or a molecular pattern associated with damage [8]. Necrotic cells may use either pannexin channels or connexin hemichannels to release intracellular ATP, and the P2X7R may be involved in this process [6]. Adenosine is a nucleoside that mediates anti-inflammatory and immunosuppressive actions, such as inhibiting the production of pro-inflammatory cytokines and lymphocyte proliferation [9]. In pathological conditions, adenosine plays a protective role acting as an endogenous regulator of innate immunity and in host defense against excessive tissue damage associated with inflammation [10]. The A1 and A2A receptors (A1R and A2AR) are activated by adenosine concentrations in the nanomolar range, while the A2B and A3 receptors (A2BR and A3R) become active only when the extracellular levels of adenosine rise in the micromolar range during periods of inflammation, hypoxia or ischemia [11] (Figure 1). Other nucleosides are recognized by several P2 receptors, which are going to explain later.
Infected cells release nucleotides and nucleosides. High ATP concentration can induce both dead cell (dashed line, in dendritic cell) and several functions over immune cells as maturation, and quimiotaxis. Low ATP concentration ([ATP]) can induce (arrow) or inhibit (bar-headed line) responses depending on the immune cell. Low adenosine concentration ([ADO]) can induce ROS and NO. High adenosine concentration ([ADO]) inhibit pro-inflammatory cytokine (*Cytokines) expression. Reddish and bluish background means pro-inflammatory and anti-inflammatory context, respectively. Source: The figure 1 design is original and cell vectors were modified from freepik’s:
In the context of the immune response, as mentioned, while the extracellular ATP (eATP) exhibits pro-inflammatory and stimulatory effects in the immune system, either appropriate or exacerbated responses [6], adenosine has primarily anti-inflammatory and inhibitory effects [9]. Therefore, the balance between ATP versus adenosine levels is important in modulating cellular immune responses and pathogen survival [12]. The concentrations of extracellular nucleotides and nucleosides are regulated by immune and non-immune cells through the action of enzymes anchored to the cell membrane, with their catalytic site facing the extracellular environment [13]. These enzymes, called ectonucleotidases, hydrolyze extracellular nucleotides into their respective nucleosides to control exacerbated levels of nucleotides and maintain steady-state conditions [12]. Among them, ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases, CD39, or apyrases), hydrolyzes both ATP and ADP to AMP, in the presence of divalent cations such as calcium and magnesium. Sequentially, the E-5′-nucleotidase (CD73) terminates the ectonucleotidase cascade with the hydrolysis of monophosphate nucleotides, resulting in adenosine. This in turn is hydrolyzed by the enzyme adenosine deaminase (E-ADA), transforming adenosine into inosine, its inactive metabolite [13]. In addition, the ecto-nucleotide pyrophosphatase/phosphodiesterases (E-NPPs) yield free nucleosides. The nitrogenous bases are hydrolyzed from nucleosides by the action of phosphorylases that yield ribose-1-P and free bases. If the nucleosides and/or bases are not re-utilized, the purine bases are further degraded to uric acid [3].
Two important environments for the highly reported purinergic signaling activation are the central nervous system (CNS) and the blood. The principal cell type in the brain involved in ATP degradation is the microglia through the expression of CD39 [14]. The ATP-regulation in the blood is mediated by the red blood cells, which may regulate tissue circulation and O2 delivery by releasing the vasodilator ATP in response to hypoxia. When released extracellularly, ATP is rapidly degraded to ADP in the circulation by ectonucleotidases. Moreover, ADP acting on P2Y13 receptors on red blood cells serves as a negative feedback pathway for the inhibition of ATP release [15].
Nucleosides and nucleotides are recognized by purinergic receptors P1, P2, TLRs, and NLRs. The recognition implies that nucleosides and nucleotides are temporarily held at different concentrations to activate their respective receptors. Purinergic receptors are divided into two families: P1 and P2 receptors [1]. The G-protein coupled metabotropic P1 receptors recognize exclusively extracellular adenosine and can be subdivided into A1R, A2AR, A2BR, and A3R. The P2 receptors can be subdivided into two subtypes: non-selective ion-gated channel P2X receptors (that recognize ATP) and G-coupled P2Y receptors (that recognize ATP, ADP, UTP, UDP, and UDP-glucose) [6]. Actually, it has been described seven P2X receptors (from P2X1 to P2X7) with different affinities for ATP. The P2X7 receptor has a low affinity for ATP (requiring ≥100 mM to be activated; while others can be activated at lower concentrations) [12].
The consensus about the relationship between purinergic signaling and the immune system can be summed up by the opposing effects of ATP and adenosine. The ATP contributes to triggering the inflammatory response along with molecular patterns associated with pathogens [5]. Conversely, the adenosine nucleoside mediates anti-inflammatory and immunosuppressive actions, such as inhibiting the production of pro-inflammatory cytokines and lymphocyte proliferation [9]. However, there are other nucleotides and nucleosides modulating the immune system.
The eATP released from stressed, dying or infected cells bind to P2 receptors (as P2X7R) and may lead to pathogen elimination through several mechanisms: (1) host cell death; (2) inflammasome activation and IL-1β secretion; and (3) production of reactive oxygen species (ROS) and nitric oxide (NO); promoting lysosome and phagosome fusion [16].
P2X7R activation is associated with pore formation, which depends on the concentration and duration of ATP treatment [17], as well as leads to the opening of pores that allow the passage of small molecules (< 900 Da) [18] as dinucleotides or nucleosides, increasing the extracellular concentration of these purinergic ligands. Inflammasomes are multi-protein complexes assembled in the host cell in response to infection or cellular stress, leading to non-homeostatic and lytic cell death, called pyroptosis. P2X7R was shown to activate NLRP3 inflammasomes [19]; and recently, caspase-11-induced pyroptosis was shown to require pannexin-1 channels and the P2X7R activation [20]. Pyroptosis is important because of the cytokines, chemokines, and damage-associated molecular patterns (DAMPs) which are released to the extracellular compartment, and also because intracellular pathogens are exposed to extracellular immune response, thus allowing their destruction [21]. At the same time, the inflammasomes lead to the maturation and secretion of pro-inflammatory cytokines, such as IL-1b and IL-18 [21]. IL-1β affects virtually all cells and organs of the body and is one of the most important cytokines that mediate autoimmunity, infections, and degenerative diseases [22]. This cytokine has a role in the CNS as an endogenous pyrogenic agent, and it can also induce inflammation, leukocyte recruitment, and Th17 profile immune responses [23]. In addition to eATP, uridin diphosphate (UDP) is released by the cleavage of pannexin-1 channels via caspase in apoptotic cells resulting from the vesicular stomatitis virus infection. Then, the UDP-P2Y6R signaling is able to protect both cells and mice from infection through an increase in IFN-β production, in acute neurotropic infection [24].
Purinergic receptors P1 (P1R) and P2 (P2R) can be expressed simultaneously in almost all immune cells, apparently depending on their ligand concentrations in the extracellular space [25]. Therefore, eATP-P2R interactions also activate pro-inflammatory responses in immune cells [26], as we have seen in infected or dying non-immune cells.
Neutrophils, granulocytes participating in both immune systems innate and adaptative, are the first immune cells in arrived at the inflammation site, constituting the main acute inflammatory response against pathogens by both phagocytosis and the oxidative microbicidal molecules production [25]. Neutrophils are the more affected cells by the purinergic signaling, probably because they express several purinergic receptors [26]. For instance, P2Y11 receptor (P2Y11R) is responsible for the ATP-mediated differentiation and maturation of granulocytic progenitors in the bone marrow [27]. Also, the interaction between eATP-P2Y11R mediates the inhibition of neutrophil apoptosis [28] and increases the chemotactic response of neutrophils [29]. In addition to eATP, other nucleotide released by damaged cells is the uridine 5′-diphosphoglucose (UDP-glucose), which activates the P2Y14R signaling. UDP-glucose promotes chemotaxis of freshly isolated human neutrophils through P2Y14R activation [30]. Moreover, some inflammatory diseases have been related to P2Y14R activation. During pelvic inflammatory disease, in the endometria in both women and female mice, the P2Y14R and pro-inflammatory cytokines as IL-8 are up-regulated in the epithelium [31]. Then, the design of therapies to modulate mucosal immunity may be done by targeting P2Y14R [30].
Occasionally, some nucleosides are more concentrated than the ATP in the extracellular matrix. When uridine triphosphate (UTP) is more available than ATP, P2Y2 receptors (P2Y2R) may be activated by either ATP or UTP mediating several activities in the P2Y2R expressing cells. For instance, fibrotic lung disease is related to some activities mediated by P2Y2R such as the lung fibroblast’s proliferation and migration, the recruitment of neutrophils, and IL-6 secretion in the lungs [32]. By the other way, when the eATP-P2X1R signaling is activated in neutrophils and platelets, activated neutrophils are recruited to the injury site and their adherence to vessel walls together with the platelets occurred, promoting both thrombosis and fibrinogenesis [33].
In addition to neutrophils, the eosinophils, and basophils, other granulocyte cells, which are activated during parasitic infections and allergies, are also regulated by the purinergic system. The accumulation of eosinophils during lung inflammation is triggered by UTP-P2Y2R interaction that induces the expression of VCAM-1, an adhesion molecule, which in turn, induces changes in endothelial cell shape for the opening of passageways through which eosinophils migrate [34]. Moreover, P2Y2R activation by ATP in eosinophils has been reported to induce chemotaxis in allergic lung inflammation [35]. In other circumstances, when UDP have more concentrated than UTP or ATP, the UDP-P2Y6R signaling induces IgE-dependent degranulation in human basophils [36].
During infections, dendritic cells (DCs) are responsible for presenting antigens to naive T cells and activating them, making a link between the innate and adaptive immune response [37]. The ATP-P2R interaction is involved in the migration and differentiation of DCs [38]. Specifically, the eATP-P2Y11R interaction modulates the maturation of human monocyte-derived dendritic cells (MoDCs) [39]. Moreover, P2Y2R activation by ATP promotes chemotaxis of MoDCs [35]. In fact, the eATP-P2Y11R interaction mediates the migration of DCs accordingly with the DC type, although all DC populations express P2Y11R. MoDCs down-regulate the P2Y11R expression, decreasing the inhibition of migration triggered by ATP. While either interleukin-3 receptor-positive plasmacytoid DCs or CD1c + peripheral blood DCs do not inhibit their migration by ATP. Then, the possibility of a meeting between DCs and antigens may be mediated by gradients of ATP formed in and around inflamed areas. Therefore, after vaccination, the migration of DCs charged with antigens to near lymph nodes may be increased with the inhibition of P2Y11R expression. This strategy could improve the time of response after vaccination [38]. In addition, P2Y12 receptor (P2Y12R) modulates murine DCs function by ADP, including induction of intracellular Ca2+ transportation, macropinocytosis, and T-cell stimulation [40]. However, the stimulation of the P2X7R with ATP can induce cell death; such as in murine spleen-derived DCs, which increase the permeabilization and the intracellular calcium, resulting in apoptosis [41].
As reviewed, the T-cell activation by DCs can be modulated by the purinergic system. Additionally, lymphocytes (mainly T and B cells) that are characterized by expressing antigen receptors, allowing the activation of anti-microbial responses [25], also express purinergic receptors which modulates lymphocyte proliferation, differentiation, and functioning. Immature T cells pass through the thymus for differentiation, where stromal epithelial cells are in charge of both the positive and negative selection processes, which in turn defines the T cell functional profile between CD8+ or CD4+ cells [42]. In the thymus, P2X7R and P2Y2R are expressed in several cells as murine thymic epithelial cells (TECs), leading to the release of calcium from intracellular stores and increasing the permeabilization membrane [43]; possibly leading to TECs apoptosis as well as reported in DCs [41], and ending in the alteration of both T-cell differentiation and their peripheral functioning. Similarly, the eATP-P2X7R signaling leads to the opening of a transmembrane cationic channel that allows K+ efflux and Na + and Ca2+ influx and promotes cytoplasmic membrane depolarization in the phagocytic cell of the thymic reticulum [18], leading to increase permeabilization and apoptosis, and impairing of T-cell precursors proliferation.
During immune synapse, naïve T-cells release ATP throughout pannexin-1 channels, then the eATP interaction with P2X1R and P2X4R receptors regulates T-cell activation, calcium entry, and IL-2 release [44]. Also, γδ T-cells, abundant at barrier sites such as the skin, gut, lung, and reproductive tract, are activated and upregulated tumor necrosis factor-alpha (TNF-α), and interferon-γ (IFN-γ) release through the eATP-P2X4R interaction [45]. Moreover, P2X4Rs participate in the migration process of CD4+ T-cells. This migration is mediated by the chemokine stromal-derived factor-1α (SDF-1α), which triggers the T-cell polarization by the accumulation of ATP producing mitochondria near ATP-releasing pannexin-1 channels and newly expressed P2X4Rs. This set of molecules promotes both the Ca2+ influx and sustained mitochondrial ATP production required for the pseudopod protrusion and T-cell migration [46]. Conversely, exogenous activation of P2Y11R with eATP blocks T-cell trafficking [47].
Specifically, the purinergic system may modulate inflammatory severe clinical conditions like sepsis. This condition has two phases, first is the hyperinflammatory phase, which may be later restricted by the immunosuppressive phase. However, this last phase characterized by high blood levels of regulatory T cells (Tregs) is strongly associated with mortality. Tregs proliferation is controlled by P2Y12R activation in both Tregs and platelets, and P2Y12R blockade restores the immunological homeostasis. Therefore, this strategy may guide pharmacological treatment for sepsis and increase patient survival [48].
Among innate immune cells acting mainly in chronic inflammatory responses are the mononuclear phagocytes, which are in circulation as monocytes or in several tissues as macrophages, or in specific tissues as microglial cells in the brain. These phagocytes may have either a pro-inflammatory or anti-inflammatory role depending on the type of cytokines around them and express several P2 receptors [25]. For instance, the major pathway of macrophage activation is the eATP-P2Y11R signaling, which leads to cytokine release [49]. Moreover, macrophages exposed to LPS, increase the P2YR and P2X7R activation mediated by eATP, modulating the IL-1β, TNF-α, and NO production [50]. Monocyte adhesion process is also regulated by the ATP-P2R interaction [51]. For example, activated P2Y12R induces both vascular smooth muscle inflammatory changes via MCP-1 upregulation and monocyte adhesion into the vascular wall, promoting atherosclerotic lesions [52].
Microglia is the cell responsible for the immune function of the nervous system in both physiological and pathological conditions [53]. Increased P2X7R expression and its ATP-mediated activation in microglia are observed after the LPS brain challenge, leading to increased immune response associated with NO and ROS, along with reduced neuronal viability. Inhibition of this purinergic response may be a neuroprotective strategy in brain inflammatory diseases [54]. In addition, the upregulation of P2Y6, P2Y12, P2Y13, and P2Y14 receptors in spinal microglia is associated with the development of neuropathic pain [55]. In an inflammatory context, ADP acting on P2Y12R induces extension of microglia processes thereby attracting this cell to the site of ATP/ADP leaking or release. Moreover, the ADP-P2Y12R activation in microglia induces intracellular calcium accumulation, which in turn causes the increase of CC chemokine ligand 3 (CCL3) expression in the peripheral injured site and also in the spinal cord, inducing neuropathic pain. Since the inhibition of CCL3-CCR5 signaling suppresses the development of neuropathic pain, treatments based on inhibition of CCL3 expression can be promising to control this kind of inflammatory disorder [56].
The P2Y6R is also upregulated in microglia when neurons are damaged, then the UDP-P2Y6R signaling facilitates microglial phagocytosis [57]. Consistently, the brain injury caused by ischemic accidents is increased by the inhibition of both P2Y6R expression and the microglia-phagocytic activity [58]. The UDP-P2Y6R signaling is also associated with neuropathic pain and is partially explained by the induction of CCL2 production through the MAP kinases-NF-kappaB pathway in microglia [59]. CCL2 is a recruitment factor of myeloid cells to the regions with injured neurons. In the spinal cord, CCL2 released from primary afferent neurons and reactive astrocytes could contribute to either the induction or maintenance of chronic pain [60], neurodegenerative and neuroinflammatory diseases [61].
As mentioned above, in addition to purinergic receptors, other receptors are able to recognize eATP such as the NLRs and TLRs. These receptors recognize both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (including eATP and uric acid). The relationship between these receptors and nucleotides or nucleosides, and the structure and functions of NLRs will be addressed immediately. TLRs will be explained through the case of gout disease.
The NLRs are cytoplasmic receptors and the structure has three domains: a common domain organization with a central conserved domain NOD (NACHT: NAIP, CIITA, HET-E, and TP-2), N-terminal effector domain, and C-terminal leucine-rich repeats (LRRs) [62]. The NAIP motif (neuronal apoptosis inhibitor protein) and the CIITA motif (MHC class II transcription activator) contain a distinct predicted nucleoside triphosphatase (NTPase) domain. In addition, NTPase domain in CIITA shows highly significant sequence similarity to CARD4 (pro-apoptotic protein). Therefore, the NACHT family includes both pro-apoptotic (e.g. CARD4) and anti-apoptotic (e.g. NAIP) predicted NTPases [63]. In consequence, all NLRs could modulate apoptotic process. However, either the possible apoptotic effect or the ATPase activity of the NATCH domain and the consequence on the concentration of nucleotides and derivatives in the cytoplasm must be the subject of study.
Most NLRs recognize various ligands activating inflammatory responses. These ligands come from different sources, including microbial pathogens (peptidoglycan, flagellin, viral RNA, fungal hyphae, etc.), host cells (ATPs, uric acid, etc.), and esteril activators (alum, silica, UV radiation, skin irritants, etc.). In addition, some NLRs respond to cytokines such as interferons. The activated NLRs show various functions that can be divided into four broad categories: inflammasome formation, signaling transduction, transcription activation, and autophagy [64]. Several NLRs have been used to identify inflammasomes, depending on the receptor that recognizes the PAMPs (for example, NLRP1, NLRP3, AIM2, NLRC4), while the other group of inflammasomes can be activated by cytosolic lipopolysaccharides (LPS) derived from gram-negative bacteria. The NLRP3 inflammasome can be activated by different stimuli, such as bacterial, viral, and fungal pathogens, pore-forming toxins, crystals, silica, and DAMPs (for example, eATP) [65]. The activation of the NLRP3 inflammasome requires two signals: (1) a PAMP, such as LPS, leading to transcription of NF-kB, upregulating genes encoding pro-inflammatory cytokines, chemokines, and proteins involved in the inflammasome platform; and (2) a DAMP, such as eATP, which induces inflammasome activation after ligation to the P2X7R. Once activated, these complexes promote activation of the protease caspase-1, which cleaves pro-IL-1β and pro-IL-18 into their active forms: IL-1β and IL-18 [12].
In addition to the inflammasome activation, eATP induces ROS production. ROS are highly reactive chemicals formed from O2 (such as peroxides, superoxides, and hydroxyl radicals) [66]. For instance, respiratory epithelial cells induce mitochondrial ROS in response to influenza infection. ROS induces the expression of type III interferon, a response associated with viral infection control [67]. Moreover,
Some TLRs recognize in addition to PAMPs from intracellular or extracellular pathogens, others molecules like ATP and uric acid. TLRs recognizing uric acid are involved in several metabolic and cardiovascular diseases, including gout, chronic renal tubular damage, autosomal dominant polycystic kidney disease, and cartilage degeneration. Among them, the accumulation of uric acid crystals (monosodium urate - MSU -) in the joints causes arthritis which is the base of the metabolic disease called Gout [64]. The uric acid also could cause inflammatory events by the activation of the NLRP3 inflammasome and its activation induces the IL-1β formation, which leads to the development of gouty arthropathy [69]. Moreover, when the level of uric acid is higher than 6.8 mg/dL, MSU crystals are formed and are recognized by TLRs. These TLRs then activate the NALP3 inflammasome. MSU also triggers neutrophil activation and further produces immune mediators, which lead to a pro-inflammatory response [70]. In the mice model of Gout, it was found that MSU crystals are recognized by TLR2 and TLR4 with the participation of the TLR adapter protein myeloid differentiation factor 88 (MyD88) in bone marrow-derived macrophages. After recognition by these TLRs, MSU induced the production of pro-inflammatory cytokines as IL-1β, TNF-α, keratinocyte-derived cytokine/growth-related oncogene alpha (KDC/GROα), and transforming growth factor beta1(TGF-β1). Moreover, neutrophil influx, local induction of IL-1β, and more pro-inflammatory reaction were promoted [71].
In addition, patients with hyperuricemia (high levels of uric acid in the blood) develop vascular diseases associated with the formation of aminocarbonyl radicals from excess uric acid with the concomitant oxidative effect [72]. Additionaly, metabolic and cardiovascular diseases are associated with the activation of the renin-angiotensin system (RAS) mediated by uric acid, in adipose tissue. For instance, high blood pressure and increased expression of both TLR2/4, pro-inflammatory cytokines (TNF-α and IL-6), and RAS activation in adipocytes were found in hyperuricemic rats. These high levels of cytokines and RAS components were reverted by TLR2/4 RNA silencing [73]. Proinflammatory pathways are induced by uric acid and angiotensin II-mediated by TLR4 in renal proximal tubular cells developing chronic tubular damage [74]. Moreover, TLR-2 and TLR-4 gene expressions are associated with rapid progression in autosomal dominant polycystic kidney disease (ADPKD) patients [75]. Furthermore, in human chondrocytes, the accumulation of both calcium pyrophosphate dihydrate (CPPD) and MSU crystals was associated with increased expression of TLR2 and the NO generation triggered by TLR2 signaling, inducing inflammation and cartilage deterioration. Other TLR signaling pathways producing NO release are induced by both MSU and CPPD crystals, including the Pl3K/Akt/NF-κB signaling pathway and other mediators as MyD88, IRAK1, and TRAF6 [76].
In the lymph nodes and spleen, lymphocytes are stimulated through eATP-P2X7R interaction to promote the Th1 pro-inflammatory response [77]. However, the eATP may also play an immunosuppressive role. This mechanism occurs mainly when eATP is in low (micromolar) concentrations, increasing its affinity for P2YR, located on the surface of lymphocytes. When stimulated, P2YRs promote the downregulation in the expression and release of pro-inflammatory cytokines, promoting a protective effect against excessive tissue damage [25]. Moreover, chronic exposure of DCs to low ATP doses reduces the capacity to stimulate the Th1 response, while Th2 response is favored [78], which induces the activation of T-cells with an anti-inflammatory profile. However, micromolar levels of eATP through P2Y2R induce the mechanisms of phagocytosis and increase ROS and NO production by macrophages and neutrophils [25].
The most recognized effector of anti-inflammatory responses of the purinergic system is adenosine. Extracellular adenosine is recognized by P1 receptors (A2AR and A2BR). High concentrations of adenosine activate A2AR, inhibiting the production of pro-inflammatory cytokines by macrophages [79], and also decreasing the production of ROS and NO by neutrophils, monocytes, and macrophages. However, low concentrations of adenosine (lower than micromoles) increase phagocytosis and ROS production by activation of A1R in neutrophils [25]. Also, adenosine acts on A2AR inhibiting the production of IL-12 and TNF-α in mice liver and preventing the damage by injury [10].
A1AR and A2AR are abundantly expressed at synapses in the CNS, modulating the synaptic efficacy [80]. A1AR and A2AR receptors are also expressed in the microglia and their activation promotes anti-inflammatory and migration activities, respectively [81]. In the presence of mild alterations of CNS high amounts of ATP can be release, then the activation of P2X7R induces both activation and pro-inflammatory response by microglia, leading to surrounding neuronal death [82]. Therefore, the ATP regulation in the CNS is critical; it has been suggested that CD39 expression has an essential role in cell proliferation and growth, inflammatory processes, and triggering cellular responses from ATP-induced contribute to apoptosis and host defense [83]. Moreover,
Some obligated intracellular bacterial pathogens have diverse target organs. For instance,
Another bacteria controlled by eATP-triggered mechanisms is
Intracellular protozoan parasites as
During the acute toxoplasmosis, in the mice brain, occurs an increase in purines (ATP, ADP, AMP, adenosine, xanthine, hypoxanthine, and uric acid), while in chronic toxoplasmosis reduction of the same purines, except the antioxidant, uric acid, occurs [103]. Specifically, the high levels of xanthine and hypoxanthine are associated with the inhibition of the enzyme xanthine oxidase, which catalyzes the production of uric acid, reported in
Interestingly,
During acute
Interestingly, some pathogens have evolved extracellular nucleotide-hydrolyzing enzymes that mimic the ectonucleotidases expressed in the host, probably inhibiting the ATP-driven immune response [114]. For instance, the surface of
The participation of the purinergic system in the immune response and pathogenesis as a consequence of SARS-CoV-2 virus infection has also been reported. SARS-CoV-2 induces the IFN response in patients, through MDA5-mediated RNA sensing with the participation of IRF3, IRF5, and NF-κB/p65 pro-inflammatory transcription factors [117]. However, Coronaviruses can evade the MDA5 recognition by forming endoplasmic reticulum-derived membrane vesicles around their RNA [118], delaying the IFN production; and in consequence, allowing higher viral replication. Viral load is highly correlated with the levels of IFNs and TNF-α, suggesting that viral load may drive high cytokine production [119]. Increased levels of TNF-α during inflammation induce ATP release via pannexin-1 channels [120]. ATP exportation out of the cell implies a deficit of intracellular ATP available for the ATP-dependent enzymes in the JAK–STAT pathway induced by IFN-I, limiting the cytokine expression and T helper cell activation [121].
At the same time, a pro-inflammatory immune response is initiated by the increase in the extracellular ATP and ADP levels in the microenvironment of immune cells activating the P2XRs and P2YRs [122]. The eATP-P2X7R signaling activation is a key process in the hyper inflammation resulting from the severe pro-inflammatory immune response against SARS-CoV-2 [123]. High levels of eATP are accompanied by the desensitization of all P1 and P2 purinergic receptors, except P2X7R, inducing more hyper inflammation [124], the worst scenario for a COVID-19 patient.
Shortly after the inflammatory explosion or simultaneously, the eATP concentration could decrease by the CD39-mediated transformation into eADP and eAMP, while adenosine quickly increases by the CD73-mediated eAMP conversion [125]. Then, immunosuppressive responses are activated by the adenosine excess in interaction with their A2AR and A2BR, including inhibition of macrophages and lymphocytes [10].
Moreover, increased eADP levels promote platelet activation and intravascular thrombosis mediated by P2YRs [126], and COVID-19 patients with pneumonia frequently developed microvascular thrombosis in their lungs [127]. In summary, the degree of involvement of purinergic receptors and their ligands in the response to SARS-CoV-2 virus infection may partially explain, the presence of asymptomatic infected people and the variation in the severity among the COVID-19 patients.
During inflammation, macrophages, NK cells, and some lymphocytes activities are impaired by the interaction of their adenosine receptors and the high extracellular levels of adenosine [10]. Therefore, the factors involved in extracellular adenosine production may be used in anti-inflammatory strategies, including the ectonucleotidases CD39 which degrades ATP into AMP, and the ectonucleotidase CD73 which converts AMP into adenosine. Following this rationale, several monoclonal antibodies (mAb) have been developed using CD73, CD39, and A2AR receptors as a target [128]. For instance, a humanized anti-CD39 mAb prevents the ATP-ADP conversion. Moreover, the enhancement of T cells and NK cells function was found, when CD39 was blocked by either antibodies or inhibitors such as POM-1; aside from increased T cell proliferation by the lack of suppression exerted by Treg cells [129].
Moreover, the prevention of AMP to adenosine conversion is also achieved using the mAb anti-CD73 which leads to its internalization [130]. As consequence, the adenosine low levels can not inhibit lymphocytes, therefore CD8 and macrophages activities are enhanced, while both myeloid suppressor cells and Treg lymphocytes are inhibited [128]. Lymphocyte proliferation is also promoted with the administration of an A2AR antagonist in two ways, removing checkpoints on both CD4+ FoxP3+ Tregs and CD8+ effector T cells development, and inhibiting the expression of the programmed death-1 receptor (PD-1) in draining lymph nodes [131]. Some of these drugs have been used as anti-cancer therapies, nevertheless, they have a potential action in many diseases based on immunosuppressive mechanisms.
On the other hand, antagonists of P2X7R as lidocaine can disrupt hyperinflammation, leading to the activation of anti-inflammatory responses. For instance, the clonal expansion of Tregs in lymph nodes is promoted by the P2X7Rs-mediated inhibition of the immune cells in the lymphatic system. Later, the Tregs control the hyperinflammation throughout their anti-inflammatory mechanisms [16]. Also, since eATP-P2Y11R signaling is highly activated in macrophages, P2Y11R antagonists maybe they can be used for the treatment of inflammatory diseases [40]. These strategies may constitute immunotherapy with promising results for inflammatory-based diseases, such as severe forms of various viral or bacterial infections, or even autoimmune diseases.
PX and PY receptors are involved in the inflammasome activation, apoptosis induction, oxidant production and activation of several immune cells, mechanisms that can control the infection of several pathogens. Conversely, adenosine is generally associated with the downregulation of inflammation. However, the effects triggered by eATP and nucleosides and their respective purinergic receptors in infected cells, depend on several aspects. These include first, the ability of the receptor expression by infected cells; second, the mechanisms to maintain the balance of nucleotide and nucleoside concentrations in the extracellular environment; and third, the survival strategies of specific pathogens.
The purinergic signaling can modulate infections by different intracellular pathogens, including viruses, bacteria, and parasites, and mediates inflammatory processes in metabolic, cardiovascular, and cancer diseases. For this reason, this knowledge field represents an important focus for future research regarding the survival and elimination of different pathogens and the maintenance of the homeostasis of the diseases related to hyper-inflammation.
Post-doctoral Fellowship of Research Support Foundation of the State of Rio de Janeiro–FAPERJ—Health Research Networks Program in the State of Rio de Janeiro—2019, Brazil. Processo E-26/ 202.139/2020.
The authors declare no conflict of interest.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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This chapter thus briefly discusses different biological methods, specially biofilm technologies, the development of biofilms on different filter media, factors affecting their development as well as their structure and function. It also tackles various conventional and modern molecular techniques for detailed exploration of the composition, diversity and dynamics of biofilms. 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Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. El- Zairy",authors:[{id:"90645",title:"Dr.",name:"Hassan",middleName:null,surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",middleName:null,surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}]}],mostDownloadedChaptersLast30Days:[{id:"65613",title:"The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents",slug:"the-methods-for-detection-of-biofilm-and-screening-antibiofilm-activity-of-agents",totalDownloads:9277,totalCrossrefCites:15,totalDimensionsCites:26,abstract:"Biofilm producer microorganisms cause nosocomial and recurrent infections. Biofilm that is a sticky exopolysaccharide is the main virulence factor causing biofilm-related infections. Biofilm formation begins with attachment of bacteria to biotic surface such as host cell or abiotic surface such as prosthetic devices. After attachment, aggregation of bacteria is started by cell-cell adhesion. Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"62553",title:"Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance",slug:"antibiotic-use-in-poultry-production-and-its-effects-on-bacterial-resistance",totalDownloads:7327,totalCrossrefCites:43,totalDimensionsCites:92,abstract:"A surge in the development and spread of antibiotic resistance has become a major cause for concern. Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"65914",title:"Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance",slug:"introductory-chapter-the-action-mechanisms-of-antibiotics-and-antibiotic-resistance",totalDownloads:4428,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu, Nesrin Gareayaghi and Bekir S. Kocazeybek",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"},{id:"248288",title:"Prof.",name:"Bekir",middleName:null,surname:"Kocazeybek",slug:"bekir-kocazeybek",fullName:"Bekir Kocazeybek"},{id:"406463",title:"Dr.",name:"Nesrin",middleName:null,surname:"Gareayaghi",slug:"nesrin-gareayaghi",fullName:"Nesrin Gareayaghi"}]},{id:"50992",title:"Probiotics: A Comprehensive Review of Their Classification, Mode of Action and Role in Human Nutrition",slug:"probiotics-a-comprehensive-review-of-their-classification-mode-of-action-and-role-in-human-nutrition",totalDownloads:5429,totalCrossrefCites:16,totalDimensionsCites:28,abstract:"Probiotics are live microorganisms that live in gastrointestinal (GI) tract and are beneficial for their hosts and prevent certain diseases. In this chapter, after a complete introduction to probiotics, definition, mechanism of action, and their classification, currently used organisms will be discussed in detail. Moreover, different kinds of nutritional synthetic products of probiotics along with their safety and drug interaction will be noticed. This chapter mentions all clinical trial studies that have been done to evaluate probiotic efficacy with a focus on gastrointestinal diseases.",book:{id:"5193",slug:"probiotics-and-prebiotics-in-human-nutrition-and-health",title:"Probiotics and Prebiotics in Human Nutrition and Health",fullTitle:"Probiotics and Prebiotics in Human Nutrition and Health"},signatures:"Amirreza Khalighi, Reza Behdani and Shabnam Kouhestani",authors:[{id:"179560",title:"Dr.",name:"Amirreza",middleName:null,surname:"Khalighi",slug:"amirreza-khalighi",fullName:"Amirreza Khalighi"},{id:"185238",title:"Dr.",name:"Reza",middleName:null,surname:"Behdani",slug:"reza-behdani",fullName:"Reza Behdani"},{id:"185239",title:"Dr.",name:"Shabnam",middleName:null,surname:"Kouhestani",slug:"shabnam-kouhestani",fullName:"Shabnam Kouhestani"}]},{id:"56849",title:"Physiology and Pathology of Innate Immune Response Against Pathogens",slug:"physiology-and-pathology-of-innate-immune-response-against-pathogens",totalDownloads:6226,totalCrossrefCites:21,totalDimensionsCites:28,abstract:"Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response and an antigen-specific adaptive immune response. The innate response is characterized by being the first line of defense that occurs rapidly in which leukocytes such as neutrophils, monocytes, macrophages, eosinophils, mast cells, dendritic cells, etc., are involved. These cells recognize the pathogen-associated molecular patterns (PAMPs), which have been evolutionarily conserved by the diversity of microorganisms that infect humans. Recognition of these pathogen-associated molecular patterns occurs through pattern recognition receptors such as Toll-like receptors and some other intracellular receptors such as nucleotide oligomerization domain (NOD), with the aim of amplifying the inflammation and activating the adaptive cellular immune response, through the antigenic presentation. In the present chapter, we will review the importance of the main components involved in the innate immune response, such as different cell types, inflammatory response, soluble immune mediators and effector mechanisms exerted by the immune response against bacteria, viruses, fungi, and parasites; all with the purpose of eliminating them and eradicating the infection of the host.",book:{id:"5975",slug:"physiology-and-pathology-of-immunology",title:"Physiology and Pathology of Immunology",fullTitle:"Physiology and Pathology of Immunology"},signatures:"José Luis Muñoz Carrillo, Flor Pamela Castro García, Oscar\nGutiérrez Coronado, María Alejandra Moreno García and Juan\nFrancisco Contreras Cordero",authors:[{id:"214236",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Muñoz-Carrillo",slug:"jose-luis-munoz-carrillo",fullName:"Jose Luis Muñoz-Carrillo"},{id:"216080",title:"Dr.",name:"Alejandra",middleName:null,surname:"Moreno-García",slug:"alejandra-moreno-garcia",fullName:"Alejandra Moreno-García"},{id:"216081",title:"Dr.",name:"Oscar",middleName:null,surname:"Gutiérrez-Coronado",slug:"oscar-gutierrez-coronado",fullName:"Oscar Gutiérrez-Coronado"},{id:"216082",title:"Dr.",name:"Pamela",middleName:null,surname:"Castro-García",slug:"pamela-castro-garcia",fullName:"Pamela Castro-García"},{id:"220717",title:"Dr.",name:"Juan Francisco",middleName:null,surname:"Contreras Cordero",slug:"juan-francisco-contreras-cordero",fullName:"Juan Francisco Contreras Cordero"}]}],onlineFirstChaptersFilter:{topicId:"13",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83067",title:"Multiplicity in the Genes of Carbon Metabolism in Antibiotic-Producing Streptomycetes",slug:"multiplicity-in-the-genes-of-carbon-metabolism-in-antibiotic-producing-streptomycetes",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.106525",abstract:"Streptomycetes exhibit genetic multiplicity, like many other microorganisms, and redundancy occurs in many of the genes involved in carbon metabolism. The enzymes of the glycolytic pathway presenting the greatest multiplicity were phosphofructokinase, fructose 1,6-bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase. The genes that encode citrate synthase and subunits of the succinate dehydrogenase complex are the ones that show the greatest multiplicity, while in the phosphoenolpyruvate-pyruvate-oxaloacetate node, only malic enzymes and pyruvate phosphate dikinase present two copies in some Streptomyces. The extra DNA from these multiple gene copies can be more than 50 kb, and the question arises whether all of these genes are transcribed and translated. As far as we know, there is few information about the transcription of these genes in any of this Streptomyces, nor if any of the activities that are encoded by a single gene could be limiting both for growth and for the formation of precursors of the antibiotics produced by these microorganisms. Therefore, it is important to study the transcription and translation of genes involved in carbon metabolism in antibiotic-producing Streptomyces growing on various sugars.",book:{id:"10893",title:"Actinobacteria",coverURL:"https://cdn.intechopen.com/books/images_new/10893.jpg"},signatures:"Toshiko Takahashi, Jonathan Alanís, Polonia Hernández and María Elena Flores"},{id:"82972",title:"Actinomycosis: Diagnosis, Clinical Features and Treatment",slug:"actinomycosis-diagnosis-clinical-features-and-treatment",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.104698",abstract:"Actinomycosis is a filamentous bacterium that forms part of the normal human flora of the gastrointestinal, oropharynx and female genitalia. This indolent infection is characterized by abscess formation, widespread granulomatous disease, fibrosis, cavitary lung lesions and mass-like consolidations, simulating an active malignancy or systemic inflammatory diseases. It is subacute, chronic and variable presentation may delay diagnosis due to its capability to simulate other conditions. An accurate diagnostic timeline is relevant. Early diagnosis of pulmonary actinomycosis decreases the risk of indolent complications. Proper treatment reduces the need for invasive surgical methods. Actinomycosis can virtually involve any organ system, the infection spread without respecting anatomical variables as metastatic disease does, making malignancy an important part of the differential diagnosis. As it is normal gastrointestinal florae, it is difficult to cultivate, and share similar morphology to other organisms such as Nocardia and fungus. It is often difficult to be identified as the culprit of disease. Its true imitator capability makes this infectious agent a remarkable organism within the spectra of localized and disseminated disease. In this chapter, we will discuss different peculiarities of actinomycosis as an infectious agent, most common presentation in different organ systems, and challenging scenarios.",book:{id:"10893",title:"Actinobacteria",coverURL:"https://cdn.intechopen.com/books/images_new/10893.jpg"},signatures:"Onix J. Cantres-Fonseca, Vanessa Vando-Rivera, Vanessa Fonseca-Ferrer, Christian Castillo Latorre and Francisco J. Del Olmo-Arroyo"},{id:"82412",title:"Potential of Native Microalgae from the Peruvian Amazon on the Removal of Pollutants",slug:"potential-of-native-microalgae-from-the-peruvian-amazon-on-the-removal-of-pollutants",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105686",abstract:"Environmental pollution is a severe and common problem in all the countries worldwide. Various physicochemical technologies and organisms (e.g., plants, microorganisms, etc.) are used to address these environmental issues, but low-cost, practical, efficient, and effective approaches have not been available yet. Microalgae offer an attractive, novel, and little-explored bioremediation alternative because these photosynthetic organisms can eliminate pathogenic microorganisms and remove heavy metals and toxic organic compounds through processes still under study. Our research team has conducted some experiments to determine the bioremediation potential of native microalgae on some pollutant sources (i.e., leachate and wastewater) and its ability to remove hazardous chemical compounds. Therefore, in this chapter, we provide the results of our research and updated information about this exciting topic. Experiments were conducted under controlled culture conditions using several native microalgae species, variable time periods, different pollutant sources, and hazardous chemicals such as ethidium bromide. The results indicated that native microalgae can remove pollutants (i.e., phosphorus, ammonia, etc.) of wastewater, leachate, and some hazardous chemical compounds such as ethidium bromide. In conclusion, native microalgae have an excellent potential for removing several pollutants and, consequently, could be used to develop bioremediation technologies based on native microalgae from the Peruvian Amazon.",book:{id:"11366",title:"Microalgae",coverURL:"https://cdn.intechopen.com/books/images_new/11366.jpg"},signatures:"Marianela Cobos, Segundo L. Estela, Carlos G. Castro, Miguel A. Grandez, Alvaro B. Tresierra, Corayma L. Cabezudo, Santiago Galindo, Sheyla L. Pérez, Angélica V. Rios, Jhon A. Vargas, Roger Ruiz, Pedro M. Adrianzén, Jorge L. Marapara and Juan C. Castro"},{id:"81859",title:"Respiratory Syncytial Virus",slug:"respiratory-syncytial-virus",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104771",abstract:"Respiratory Syncytial Virus (RSV)-driven bronchiolitis is one of the most common causes of pediatric hospitalization. Every year, we face 33.1 million episodes of RSV-driven lower respiratory tract infection without any available vaccine or cost-effective therapeutics since the discovery of RSV eighty years before. RSV is an enveloped RNA virus belonging to the pneumoviridae family of viruses. This chapter aims to elucidate the structure and functions of the RSV genome and proteins and the mechanism of RSV infection in host cells from entry to budding, which will provide current insight into the RSV-host relationship. In addition, this book chapter summarizes the recent research outcomes regarding the structure of RSV and the functions of all viral proteins along with the RSV life cycle and cell-to-cell spread.",book:{id:"11369",title:"RNA Viruses Infection",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg"},signatures:"Sattya Narayan Talukdar and Masfique Mehedi"},{id:"82148",title:"Mosquito Population Modification for Malaria Control",slug:"mosquito-population-modification-for-malaria-control",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.104907",abstract:"Malaria is a mosquito-borne disease that kills millions of people every year. Existing control tools have been insufficient to eliminate the disease in many endemic regions and additional approaches are needed. Novel vector-control strategies using genetic engineering to create malaria-resistant mosquitoes (population modification) can potentially contribute a new set of tools for mosquito control. Here we review the current mosquito control strategies and the development of transgenic mosquitoes expressing anti-parasite effector genes, highlighting the recent improvements in mosquito genome editing with CRISPR-Cas9 as an efficient and adaptable tool for gene-drive systems to effectively spread these genes into mosquito populations.",book:{id:"11379",title:"Mosquito Research - Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11379.jpg"},signatures:"Rebeca Carballar-Lejarazú, Taylor Tushar, Thai Binh Pham and Anthony James"},{id:"81934",title:"Lactobacillus Use for Plant Fermentation: New Ways for Plant-Based Product Valorization",slug:"lactobacillus-use-for-plant-fermentation-new-ways-for-plant-based-product-valorization",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104958",abstract:"Today, plant production is increasing, but most industrial processes generate a lot of waste and by-products for which, in the current context, it is a priority to recycle or valorize them. One of the cheapest valorization routes is fermentation, in particular lactic fermentation by Lactobacillus species, which produces lactic acid and other molecules of industrial interest such as bioactive compounds such as anthocyanin, organic acid, peptides, or phenol, which are widely found in the plant matrix, mainly in cereals, grass, fruits, and vegetables. Bioactive compounds may exert beneficial health effects, such as antioxidant, anti-inflammatory, antimicrobial, or prebiotic activities. In addition, lactic acid fermentation can improve existing products and lead to new applications in food, livestock feeding and biotechnology, such as the production of lactic acid, protein, or silage. This chapter reviews the use of Lactobacillus strains in the fermentation process of many plant bioresources or by-products through their different bioactivities, active molecules, and applications.",book:{id:"11372",title:"Lactobacillus - A Multifunctional Genus",coverURL:"https://cdn.intechopen.com/books/images_new/11372.jpg"},signatures:"Morgan Le Rouzic, Pauline Bruniaux, Cyril Raveschot, François Krier, Vincent Phalip, Rozenn Ravallec, Benoit Cudennec and François Coutte"}],onlineFirstChaptersTotal:102},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 12th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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