Distribution of maize farmers according to the level of women participation in the post-harvest operations of maize (n = 165).
\r\n\tApplied and basic studies - Field studies and lab assays of fungicides can be discussed. We also look for examples of application methods, which may include timing of application, tools for application, fungicide compatibility, phytotoxicity, etc. Field trials have to have at least two years of data;
\r\n\tAdaptation of Integrated Plant Disease Management - How the IPM practice has been adapted in the field. Application of disease risk models, or use of fungicide application aids, which can be hardware or software. The introduction of a new tool for growers can also be included;
\r\n\tNovel fungicides - In addition to the traditional chemical approach, alternative materials (enzymes, oils, extracts, etc.), biological control agents, or plant defense activators can be discussed;
\r\n\tAdaptation of new technologies - Examples will be the use of unmanned vehicles, sensor technologies, advanced sprayers, or disease forecast systems for precision agriculture;
\r\n\tFungicide resistance - Unfortunately, we cannot ignore the fact that fungicide-resistant strains are widespread. Documentation of fungicide-resistant strains, the introduction of new technologies and methods can be discussed.
Agricultural activities are characterized by gender division of labour in the Sub-Saharan Africa and in Nigeria in particular. Thus, women are mostly found to be engaged in post-harvest activities than their men counterpart whose activities revolve round pre-production and actual production operations that are neck twisting and backbreaking, even when women do, their participation in these operations are minimal and largely dependent on the socio-cultural and agrarian setting of the place in question. The Womenfolk plays a key role in agriculture, especially in the activities revolving round harvest and postharvest. However, their contribution is always ignored and relegated to the background. It is reported by [1] that in rural Pakistan, women carryout 53% of farming activities, and devote 20% more time than men for work. Yet, they face more constraints than men as they are negatively affected by socio-cultural values, economics policies and decision making in the society. Lately, studies have shown that the underlying reasons of food losses are associated with specific socio-cultural and gender dimensions [2, 3].
\nMaize is a major staple crop in Nigeria and across Africa. It is said to be the second most common cereal food crop after rice [4]. Green fresh maize is cooked or roasted and hawked by women and children, providing a livelihood for many urban poor households. It is also used for animal feeds and in industries such as flour mills, breweries and confectioneries. Thus, increased maize production will enhance food security, serve as import substitution and earn foreign exchange for the country through export to neighbouring food deficient countries and potentially beyond [1]. In most places across the country, women are found to mostly undertake activities that range from harvesting, transportation of harvested crops from the farms to homes, processing, preservation, packaging and marketing [5]. The women equally provide about 60% of agricultural labour force and contribute to well-being of their households through their income generating activities [6].
\nHistorical trends have suggested that the majority of increased maize production in Nigeria reflects an expansion in land under its cultivation rather than an improvement in yields [7]. In 2010, the estimate for Corn production in Nigeria was put to about 8800 Metric tonnes with growth rate of −1.68% and in the year 2012, it rose to about 9410 Metric tonnes for which the growth rate was put to 1.73%. In recent time, Nigeria’s yield per hectare is found to be lower than the global yields in the 1960s (1.9 tons/ha). It falls in the range of 1.63 and 1.76 tons per hectare between 2004 and 2007, this is lower than the global average which could be found in the range of 4.88 and 4.93 tons per hectares for the same period [8]. Meanwhile, Kogi State recorded about 333.21 Metric tonnes of corn production with the area under cultivation of 206.60 Hectare in 2009 and in 2010, it increased minimally to 371.30 MT with area under cultivation of 227.05 hectares [9]. Kogi State is one of the 36 states in Nigeria and it is in the North-central of the country.
\nMaize post-harvest losses in the tropics have been estimated to be about 20% [10]. Estimated losses of Nigeria maize post-harvest to have ranged from 15 to 20%. Nigeria has a land area of 98.3 million hectares and at present about 34 million hectares or 48% are under cultivation. It has been found that more than 60% of maize produced in Nigeria’s is used industrially for the production of flour, beer, malt drink, corn flakes, starch, syrup, dextrose and animal feeds. An embargo has been placed on the importation of maize in order to boost local production to meet the consumption demand of Nigeria. This reveals significant room for the improvement of maize production in Nigeria which is necessary if the newly developing trend of exportable surplus is to be sustained and expanded.
\nAccording to [11, 12] the post-harvest operations of maize include drying, shelling, threshing, storage and marketing. Apart from the foregoing activities [13], added grading and sorting, packing and bagging, transportation, loading and unloading. Post-harvest management of maize can be categorized into four major stages [5]. The first stage is farm-gate operations which include de-sheathing and packing harvested maize cobs together when they are mature.; the second is transportation, when cobs are transported from farms to homesteads; the third is homestead activities which constitutes drying and grading of cobs, shelling of cobs and drying the grains, winnowing of grains, application of pesticides, packing grains at household level and the fourth stage is storage of maize where grains are stored for later use. Studies have shown that proper post-harvest handling can improve earnings of maize growers especially for the women folk [14, 15]. This study focused on assessing the level of women participations in post-harvest management on maize in Kogi State of Nigeria.
\nThis study was carried out in Kogi State, Nigeria. The State consists of 21 Local Government Areas. The State is located between latitude 6° 30′N and 8° 5′N and longitude 5° 51E and 8° 00E. The state is made up of four agro-ecological zones, namely: Zone A with the headquarter in Aiyetoro Gbede; Zone B has its headquarter in Anyigba; Zone C with headquarter in Koton Karfe; and Zone D has its headquarter in Alloma. This delineation or stratification of the State into these Zones was done By Kogi State Agricultural Development Projects (KSADP) in order to ease their extension service delivery for optimum results in the State.
\nThe state is well endowed with river valleys and swamps lands for dry season farming. Maize is one of the major crops grown in the state and thrives well in virtually all the agro-ecological zones of the State. For the purpose of this study registered farmers were randomly selected. A total of 168 farmers were selected for the study. A three stage random sampling technique was used. In stage one, four (3) extension blocks were randomly selected from each of the agricultural zones (A, B, C, D), that gives a total of 12 extension blocks. There are five blocks in each zone. In stage two, three (2) extension cells were randomly selected from each block, making a total of 24 extension cells. There are 8 cells in each zone. In stage three, five (7) registered farmers were randomly selected from each cell. There are 80 farmers in each cell. A total of 168 farmers were used for study. Structured questionnaire and interview scheduled were used to elicit information from the respondents. The date collected was analysed using both descriptive and inferential statistical tools. The hypothesis for the study was tested using Chi-square (X2) statistics. The calculation of Chi-square statistics is given as follows:
\nwhere χ2 = Chi-square value.
\nfo = the observed frequency of levels of women participation in post-harvest operations in the Zones (A, B, C and D).
\nfe = the expected frequency of levels of women participation in post-harvest operations in the Zones (A, B, C and D).
\nɗf = (R-1) (C-1).
\n\n
\n
The post-harvest management of maize can be discussed under the following subheadings: Storage, processing grading/sorting/packaging, transportation/loading and unloading and marketing of Maize as contained in the \nTable 1\n.
\nPost-harvest operations | \nLow (1) Freq. | \nModerate (2) Freq. | \nHigh (3) Freq. | \nNo participation (0) | \n
---|---|---|---|---|
Storage | \n27 (16.07) | \n62 (36.91) | \n71 (42.26) | \n8 (4.76) | \n
Processing | \n60 (35.71) | \n47 (27.98) | \n28 (16.67) | \n33 (19.64) | \n
Grading/sorting/packaging | \n54 (32.14) | \n29 (17.26) | \n39 (23.21) | \n46 (27.38) | \n
Transportation/loading and unloading | \n67 (39.88) | \n45 (26.79) | \n34 (20.24) | \n22 (13.10) | \n
Marketing | \n32 (19.05) | \n46 (27.38) | \n70 (41.67) | \n20 (11.91) | \n
Distribution of maize farmers according to the level of women participation in the post-harvest operations of maize (n = 165).
Field Survey, 2014.
Note: multiple responses.
The figures in parenthesis represent percentages (%).
The analysis of level of women participation in the post-harvest operations as presented in \nTable 1\n shows that 16.07, 36.91, 42.26 and 4.76% of the women maize farmers rated their participation in storage of maize as low, moderate, high and no participation respectively. Drying and storage of maize grains have always been considered as part of the domestic activities normally performed by women. This is an indication that women farmers in Kogi State participated highly in the post-harvest operations of maize. This result is in consonance with that of [16] who reported that 42.2% of women actively engaged in drying and storage of maize in five agro-climatic zones of rural Punjab, India. The construction of the storage facilities are mostly done by men. Although, women sometimes hire the men and youth in helping them construct the crib as shown in \nFigure 1\n. This construction of crib in the study area is in line with the report of [2] that carried out a study on gender post-harvest activities in Zambia, that the male support their female counterpart in constructing the storage facilities.
\nMaize cobs stored in a typical crib in Bassa, Kogi State.
Effectiveness of the preservation of maize, like that of other cereal grains and food legume, is largely hinged on the ecological conditions of storage; the physical, chemical and biological features of the grain; the period of storage; and the type and the features of the storage facilities. Maize can be stored for a long period of time in the raw form. Its shelf life is largely anchored on the prevailing weather conditions (temperature and humidity) and other factors like the moisture, pests in the stored maize and diseases. Hence, it is worthy of note that proper post-harvest management of maize involve consideration of the above factors in order to improve the shelf life of maize. The recommended quality of maize is highly dependent on control harvesting strategies employed.
\nMaize harvesting is done by separating the cob from its main stalk. The appropriate period of harvesting maize is when the stalk is dried and moisture of grain as about 20–17% [17]. Maize that is harvested dry contains 15–20% moisture at the time of harvesting. After harvesting, the husks are removed from the cob. Then shelling is done to separate the grants from the rest of the cob. In many village settings, the shelling is done by hand, or by rubbing the cob over a roughened piece of metal. However, the use of mechanical shellers for maize is fairly wide spread in West Africa, and adopting the mechanical method for shelling their maize.
\nIn order to reduce the moisture content of maize, it has to be dried to 10–11% moisture content before storing it [18]. Some have advocated drying it to moisture of 13–14% [19]. However, the former seem to increase the shelf life of stored maize because the dryer the maize, the better it is stored. For proper drying of maize, it may be left spread on a mat or any platform over several days; it could also be taken to the drying machine which blows hot air over the grains. After it must have been dried to the desired moisture content, the maize grains can then be stored in silos (metal or earthened) or in bags over a long period of time without deterioration. However, if the grains have not been thoroughly dried, they will deteriorate and become mouldy during storage.
\nIn many rural parts of West Africa, maize is not shelled before being stored. Instead it is stored on the cob, with or without the husk [7]. Quite frequently, the maize is hung over domestic fireplaces where the fire helps make it dry, keep it dry and discourage weevil attack. More commonly, the maize is stored in large circular cribs or bins, built of bamboo and palm material, on raised platforms. Fires are occasionally built underneath the bins to promote drying and to control insect pests in the stored cobs. In these methods, shelling is done only just before the maize is to be utilized or taken to market. Factors that governed the design of storage structures included: tribal inheritance, availability of local building materials, social, economic and cultural standards of the people and local customs.
\nEven though farmers have adopted some innovations in post-harvest management of their crops, farmers continue to be glued to their indigenous post-production practices because of their effectiveness and reliability over time. For example, farmers in the eastern part of Kogi State do not use industrial dryer on the corn that are meant for the next planting season as they believe it will destroy the viability of planting. Instead, they prefer the indigenous way of storing it on cobs local silos or cribs, basket or hung near fire [14]. Effective management during the post-harvest period, rather than the level of sophistication of any given technology, is the key in reaching the desired objectives.
\nSpoilage of harvested maize is prevented wholly or partly either by appropriate storage or by processing it into various storable products. Maize is consumed in many forms in different parts of the world, from maize grits, maize porridge, polenta and corn bread to popcorn and products such as maize flakes [11]. With respect to processing of maize as indicated in \nTable 1\n, it was found that 35.71, 27.98, 16.67 and 19.64% of the women maize farmers said their participation in processing of maize into consumable and marketable forms was low, moderate, high and no participation respectively. This result is in agreement with a study by [2, 16] that processing activities was low among women in Punjab, India and Malawi. Processing activities in this study is associated with those of both primary and secondary transformation of maize into consumable forms. This primary processing includes threshing, winnowing, cleaning, soaking, dehulling, grinding, while the secondary processing are activities involves changing maize into forms ready for the table. They are activities such as boiling, steaming, roasting, frying, crushing, blending, cooking and baking. Primary processing of maize is very essential in the study area as maize flour is highly demanded for across all the agro-ecological zones of the State.
\nTraditional methods of processing maize into flour using pestle and mortar, grinding stones and manually operated mills vary in detail depending on culture and geography [10]. The principles however, are the same in Kogi State, Nigeria. Maize processing essentially begins with soaking the grain and then grinding it between stones or pounding it in a mortar and pestle arrangement. During pounding or grinding the bran is removed. The grain is winnowed at intervals to remove the bran from the kernels. The dehulled grain is then pulverized into flour by further grinding or pounding. Processing of maize into desirable end products usually involves primary processing (cleaning, grading, soaking dehulling, grinding and sieving) and secondary processing (blending, cooking, frying and baking).
\nIn most West African countries, maize is commonly used to make local beer (
Mortar and pestle for threshing maize grains from the cobs.
Women dehulling and grinding maize grains.
A woman winnowing and sun drying maize.
Cornflakes are a hydrothermically treated maize product of world-wide popularity. They owe their success to their high nutrient value combined with low caloric content and good digestibility. Flaking is a process consisting of cooking fragments of cereal kernel, to a certain consistency, pressing the cooked mass between rollers to form flakes, and toasting the flakes at an appropriate temperature.
\nIn terms of sorting, grading and packaging of maize in the study area as shown in \nTable 1\n, 32.14, 17.26, 23.21 and 27.38% rated their participation to be low, moderate, high and no participation respectively. This result indicates that the participation of women farmers in Kogi State in the grading/sorting/packaging of maize was rated low. Sorting and grading are done during threshing of maize whereby, maize grains are winnowed with the lighter grains separated in as it is thrown from the container into the air taking into cognizance the direction of the wind; and bad grains can also be separated from the good ones by hand picking the bad grains as shown in \nFigure 3\n. However, packaging is done by putting the grains into woollen or polythene bags, while labelling is done by using chalk or ink inscribed on the bag with any sign or words for identification. Indigenous value added products like maize porridge (N300 per triple bag as against the N50 per single ones.
With respect to transportation of maize, 39.88, 26.79, 20.24 and 13.10% of the women farmers said their participation was low, medium, high and no response respectively. This means that the participation of women farmers in Kogi State in the transportation of maize was rated low. Transportation is done indigenously by using their head with a basket or any other container to carry the maize cobs or grains. The load could be transported using wheelbarrow or bicycle to convey harvested maize from farm to home or markets or from stores at home to the market. It is noteworthy, that women are sometimes helped by their men counterpart especially those that are married in terms of transportation of maize particularly in the area of loading and unloading, if the harvested maize is bulky. However, in some cases, improved transportation, such as lorry, pick-up van, trucks, etc., could be employed for bulkier loads especially at farm gate where many small-scale farmers put their produce together for buyers (bulk assemblers) (\nFigure 5\n).
\nWheelbarrow for conveying load.
Maize like most agricultural commodities can be marketed freshly harvested or processed. In Kogi State, local market places which are normally held at an interval of 4–5 days are the points of convergence of the farm produce, including maize. Maize processing would further enhance the chances of success in its marketing. In terms of marketing of maize in study area as reflected in \nTable 1\n, 19.05, 27.38, 41.76 and 11.91% of the women maize farmers rated their participation as low, moderate, high and no participation respectively. Women in Kogi State were found to be mostly responsible for price taking and giving in maize grain marketing. This does not mean that men do not take part in marketing of maize; but their activities in marketing of maize are minimal when compared to women involvement in same. One important feature of the markets in the study area is the presence of warehouses in and around the market which makes it easier for marketers to store their goods. \nFigure 6\n depicts a typical market with warehouses.
\nThe researcher observing the triple bagging system in front of a warehouse in the market.
One problem faced by both small and large scale maize farmers in food processing particularly if they are into traditional foods, is how to market their products at a price that will guarantee a reasonable margin of profit. The chances of success of a large scale commercial venture producing traditional food could be further enhanced, especially if they are part of a group or chain of industries, and if some of the materials which they plan to produce will be utilized by one of the other arms of the industrial establishment.
\n\n\nTable 3\n shows the analysis of Chi-square on the level of post-harvest activities among farmers in the various zones (A, B, C and D respectively). This was achieved using the observed frequencies in \nTable 2\n. The result indicated that there was a significant difference (P ≤ 0.10, P ≤ 0.05 and P ≤ 0.01 respectively) their level of post-harvest operations in storage, transportation and marketing. This implies that the null hypothesis which was stated that ‘there was no significant difference in the levels of post-harvest operations of maize in the various agro-ecological zones (A, B, C and D) of the study area’ was rejected in each case. This may not be unconnected with the fact that maize thrives well in all the agro-ecological zones of the State and by extension, a high participation of women in the post-harvest activities should be expected across the zones of the state all things being equal. There were no significant differences in in terms of grading/sorting/packaging and transportation. This could be tied to the fact that these marketing functions are activities that relatively depend on the presence of designated market places; hence, these post-harvest operations may be higher in the areas where these markets were found, and lower if otherwise.
\nLevel of participation in storage of maize | \n|||
---|---|---|---|
Zones | \nLow | \nMedium | \nHigh | \n
A | \n8 | \n15 | \n18 | \n
B | \n3 | \n25 | \n30 | \n
C | \n10 | \n10 | \n12 | \n
D | \n6 | \n12 | \n11 | \n
\n | \n|||
\n | \n\n | \n\n | \n\n | \n
A | \n10 | \n12 | \n6 | \n
B | \n20 | \n18 | \n10 | \n
C | \n20 | \n11 | \n4 | \n
D | \n10 | \n6 | \n4 | \n
\n | \n|||
\n | \n\n | \n\n | \n\n | \n
A | \n13 | \n8 | \n10 | \n
B | \n18 | \n8 | \n10 | \n
C | \n10 | \n6 | \n9 | \n
D | \n13 | \n10 | \n10 | \n
\n | \n|||
\n | \n\n | \n\n | \n\n | \n
A | \n14 | \n11 | \n4 | \n
B | \n15 | \n22 | \n12 | \n
C | \n20 | \n6 | \n8 | \n
D | \n18 | \n6 | \n10 | \n
\n | \n|||
\n | \n\n | \n\n | \n\n | \n
A | \n6 | \n10 | \n20 | \n
B | \n6 | \n18 | \n31 | \n
C | \n10 | \n4 | \n6 | \n
D | \n10 | \n14 | \n13 | \n
Frequency distribution of respondents according to their level of participation in post-harvest operations in the various zones of Kogi State.
Post-harvest operations | \nChi-square (X2) value | \nP-value | \n
---|---|---|
Storage | \n11.22\n*\n\n | \n0.10 | \n
Processing | \n8.99\nNS\n\n | \n0.10 | \n
Grading/sorting/packaging | \n0.85\nNS\n\n | \n0.10 | \n
Transportation/loading and unloading | \n13.29\n*\n\n | \n0.05 | \n
Marketing | \n16.70\n*\n\n | \n0.01 | \n
Chi-square analysis on the level of women participation in post-harvest operations of maize in the various zones (A, B, C and D) of Kogi State, Nigeria.
Significant.
Not significant.
It can be inferred that there is generally, a high participation of women farmers in the storage of maize in the study area, but low participation in transportation, grading/sorting/packaging and processing of maize were recorded. This could be due to some factors that might have directly or indirectly affected the participation of respondents. The differences that occurred in the level of participation by women in post-harvest management of maize at the various agro-ecological zones of the State because of the peculiarity of the dominance of some post-harvest handling operation in a particular zone. This can be seen as a point to harness and integrate the indigenous knowledge on post-harvest handling of maize from these areas in order to boost their post-harvest activities. Their low level of participation in some of the post-harvest operations could be tied to the fact that they had inadequate access to information and other productive resources. If they have access to productive resources, they could improve their level of participation in post-harvest activities. The adequate knowledge and attitude about the appropriate indigenous post-harvest technology to be used by the farmers for maize in a particular agro-ecology will go a long way to boost farmers’ participation in post-harvest management of maize. It is obvious that despite the existence of various improved post-harvest technologies in Nigeria, most of the women in the study area are still glued to some indigenous technologies for the reason that they might have tested and are familiar with these indigenous technologies and perhaps, they have little or no access to the improved or modern ones.
\nIn general, bulk encryption is performed through symmetric ciphers; that is, block ciphers or stream ciphers. Hash functions, message authentication codes and authenticated encryption schemes are also based on the quite similar design and security principles. All these cryptographic primitives are examples of one-way functions for which it must be computationally infeasible to find a preimage. Indeed, the only generic method to invert a given output is exhaustively searching for one of its inputs.1 This may be embodied as brute force attacks on block ciphers and stream ciphers, internal state recovery attacks on keystream generators, preimage attacks on hash functions or constructing valid messages to given tag values for message authentication codes.
The brute force attacks can be expedited significantly by utilizing very large tables that have been already prepared during the offline phase. This phase is called the precomputation phase also and is usually equivalent to exhaustive search. Nevertheless, once it is executed, the prepared tables can be used several times.
It may be possible to further improve a tradeoff attack by exploiting large amount of data (plaintext/ciphertext pairs). Biryukov-Shamir attack on keystream generators can be considered as a typical example of a tradeoff among time, memory and data [1]. One of the internal states of a long keystream sequence is recovered. However, it is still unknown how to use data to improve the tradeoff attacks on block ciphers.
The state sizes of block ciphers are not of security concern against tradeoff attacks, enabling to design ultra-lightweight block ciphers. In fact, we encounter several such block cipher designs in the literature during the last decades [2, 3, 4, 5, 6, 7, 8, 9]. However, it seems to be almost impossible to design ultra-lightweight stream ciphers due to their strict security criterion on the lower bound of their internal state sizes to resist tradeoff attacks.
The tradeoff attacks can be quite effective against some real world cryptographic primitives. The tradeoff tables can be used in practical applications to break real life ciphers such as A5/1 for the GSM encryption [10, 11, 12] or to crack passwords by finding preimages to hash functions [13, 14, 15, 16, 17]. In this chapter, we introduce briefly how to use tradeoff tables to invert small sized one-way functions. Moreover, we evaluate the state of art of the applications, raise some open problems and come up with a discussion on the countermeasures against tradeoff attacks on keystream generators.
We argue that it is possible to loosen the lower bound for the state size without sacrificing the security against tradeoff attacks and this can enable designing ultra-lightweight stream ciphers. We claim that the lower bound for the internal state size can be diminished to
It is straightforward that resistance against tradeoff attacks is not sufficient for security. Unfortunately, the security of small stream ciphers has not been studied sufficiently so far. We still do not know how to design secure and small stream ciphers. This is due to fact that almost all the stream ciphers in the literature have internal state sizes at least twice as large as their key sizes. Hence, there is almost no example in the literature to analyze. The recent small keystream generators such as Sprout [18] or Plantlet [19] are analyzed intensively in a short while and several weaknesses are discovered [20, 21, 22, 23, 24, 25, 26].
The tradeoff attacks on block ciphers so far are limited to the tradeoff between only time and memory. It is an open problem how to construct a tradeoff curve between memory and data or among memory, data and time for a single key recovery attack. We phrase the problem of
The outline of the chapter is as follows. We briefly overview the tradeoff attacks on symmetric ciphers, give some recent applications of these attacks and evaluate them in Section 2. Then, we assess the tradeoff attacks on stream ciphers and keystream generators in Section 3. We also introduce the tradeoff attacks on block ciphers, discuss the differences from those on stream ciphers and state some open problems in Section 4. We assess the internal state recovery tradeoff attacks and make an argument about the internal state sizes of keystream generators in Section 5. Finally, we introduce our concluding remarks in Section 6.
Let
The phrase” computationally infeasible” is not a formal or a precise statement. Indeed, we mean that the fastest algorithm of finding a preimage
The time complexity may be substituted by the memory complexity if we compute all the
In general, we can regard the tradeoff attacks as the attacks searching for a preimage of a one-way function by utilizing a significant memory prepared in the precomputation phase to reduce the time complexity from
It is possible to ease the problem of inverting a one-way function
We can define the problem of
It is possible to address the problem of inverting one-way function with data in stream ciphers and mount some tradeoff attacks for single key setting. We introduce these attacks in Section 3. However, it is not known in the literature yet how to associate a single key recovery attack for a block cipher as a problem of inverting one-way function with data (see Section 4 for details of the tradeoff attacks in the case of block ciphers).
One very well known way of inverting a one-way function is using Hellman tables [27]. Initially, Hellman introduced the tables only for recovering the DES keys in his original work in [27] but it can be used to invert any one-way function.
Let us assume that the input and the output sizes of a one-way function,
If a given value
Therefore, it is highly probable that
Choosing
The most significant disadvantage of Hellman tables is the high propagation of the collisions throughout the rows. If
The time complexity is
Oechslin introduces another kind of tables to invert one-way functions, which he calls rainbow tables [29]. He proposes to use a different function for the computation of each column and hence each row is constituted as
instead of
Rainbow tables have a significant advantage over Hellman tables: The collisions in different columns do not propagate in rainbow tables. So, it is possible to use only one rainbow table for covering majority of the space
Both the Hellman tables and the rainbow tables have the same tradeoff curve. But, the time complexity is
Barkan
The main building blocks of (synchronous) stream ciphers are keystream generators. The most general design principle of keystream generators make use of a state update function
The objective of the attacks on stream ciphers is twofold in general. They aim at either recovering the key or an internal state. The same approach is adopted for tradeoff attacks. The state recovery attacks are conventional examples of the problem of inverting one-way function with data in a single key attack scenario. Indeed, it is enough to recover one of the internal states occurred during the encryption process.
Babbage [32] and Golić [33] independently introduce a natural way of recovering one of the internal states by using data. They define a one-way function by extending the output function which produces enough number of output bits by calling
Another tradeoff attack on keystream generators using data is introduced by Biryukov and Shamir [1]. They propose to use Hellman tables to recover one of the internal states which produce
Both the Babbage-Golić attack and the Biryukov-Shamir attack aim at recovering one of the internal states. The online phases of these attacks are compared with the exhaustive search rather than the default tradeoff attacks. The attacks use multiple data since the one-way function they would like to invert has several outputs available. On the other hand, it is possible to define the one-way function as the function taking the
Armknecht and Mikhalev examine the keyed update functions and show that the keystream generators with keyed state update functions are secure against conventional tradeoff attacks no matter how small the internal state sizes are [18]. They also introduce an example cipher they call Sprout [18]. A keyed state update function takes the main key as the second parameter of the input to produce the next internal state from the current internal state.
The cipher Sprout is analyzed intensively in a short while and some weaknesses are discovered [20, 22]. More interestingly, special tradeoff attacks are mounted [21, 23]. Then, Armknecht and Mikhalev present another keystream generator with keyed state update. They call it Plantlet [19]. This cipher also attains significant interests of cyrptanalysts and several results are published including correlation attacks [24, 25, 26, 37, 38], some of them are even faster than exhaustive search [25]. It seems that it is indeed a challenging task for the crypto community to design keystream generators of small state sizes even if the tradeoff attacks are ignored in their security assessments.
Let
It is possible to invert
There is no known method of using multiple data to improve the tradeoff curve
and
Choosing
The problem may further be generalized as inverting only one of the
be given for
The problem of mutual inverting multiple one-way functions can be applied to stream ciphers also. Several one-way functions may be defined by choosing several
where
It may be still possible to use any number of
It seems that inverting only one specific one-way function once is not easier than the other two problems. One can use the algorithm of inverting a one-way function to invert one of
It is not known yet if these three problems are of equal difficulty. It is an open problem if the mutual inverting problem is strictly easier than the problem of inverting one of the several one-way functions. It is also an open problem that inverting one of the several one-way functions is strictly easier than inverting only one one-way function. If there is an algorithm solving problem of mutual inverting problem but not solving the problem of inverting one-way function then the security levels and the key lengths for both block ciphers and stream ciphers must be assessed again. Because, the algorithms solving mutual inverting problems efficiently can be very powerful and serious attacks on symmetric ciphers.
The online complexities of both the Babbage-Golić and the Biryukov-Shamir attacks are compared to the complexity of the exhaustive search and the security criterion on the state size of a stream cipher is imposed thereof. However, there is still a faster tradeoff attack even though the internal state size is larger than twice of the key size. It is possible to define a one-way function from a main key to its keystream piece of a stream cipher by choosing and fixing an
Any tradeoff attack on symmetric ciphers should be compared with the default tradeoff attack with its complexity
Recall that we have the tradeoff curve
Similarly, the optimum point of the tradeoff curve for the Biryukov-Shamir attack is
As a result, the tradeoff attacks aiming at the internal state recovery should be compared to the default tradeoff key recovery attack. Then, it is possible to loosen the restriction on the state size from
We briefly introduce the tradeoff attacks on symmetric ciphers and initiate hopefully a fruitful discussion about how to assess the degree of precautions or countermeasure to be taken against these attacks.
The tradeoff attacks targeting at recovering one of the internal states producing a given keystream sequence are compared to the exhaustive search attack on the corresponding key used. However, a stream cipher key can be recovered much faster thorough the default tradeoff attack. Therefore, the internal state recovery tradeoff attacks should be compared to the default key recovery tradeoff attack. In this case, it is possible to loosen the bound for the countermeasure taken against state recovery tradeoff attacks.
The internal state size is supposed to be at least twice as large as the key size if the security threshold for tradeoff attacks is taken as the complexity of the exhaustive search. This is indeed a well known and worldwide adopted security criterion. We argue that it is indeed not necessary to allocate such large internal state just for the resistance against tradeoff attacks. The internal state size is enough to be at least
We believe that it is a challenging task to design small stream ciphers and the industry requires such ciphers to use in lightweight applications such as IoT devices, wireless sensors or RFID tags.
We would like to thank Mehmet Sabır Kiraz, Ali Aydın Selçuk and Sırrı Erdem Ulusoy for their helpful comments. We also would like to thank IntechOpen LIMITED for the grant.
The authors declare no conflict of interest.
IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors. To that end we maintain a flexible Copyright Policy guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
',metaTitle:"Publication Agreement - Journals",metaDescription:"IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors",metaKeywords:null,canonicalURL:"/page/publication-agreement-journals",contentRaw:'[{"type":"htmlEditorComponent","content":"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Journal Article:
\\n\\n1. DEFINITIONS
\\n\\nCorresponding Author: The Author of the Article who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author. Co-Author: All other Authors of the Article besides the Corresponding Author. IntechOpen: IntechOpen Ltd., the Publisher of the Journal.
\\n\\nJournal: The publication as a collection of Articles compiled by IntechOpen .
\\n\\nArticle: The original literary work created by Corresponding Author and any Co Author that is the subject of this Agreement.
\\n\\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\\n\\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\\n\\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\\n\\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\\n\\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\\n\\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\\n\\n3. CORRESPONDING AUTHOR'S DUTIES
\\n\\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\\n\\n3.2 When submitting the Article, the Corresponding Author agrees to:
\\n\\n• Comply with all instructions and guidelines provided by IntechOpen;
\\n\\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\\n\\n• Submit all the corrections in due time as defined during the publishing process schedule.
\\n\\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\\n\\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\\n\\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\\n\\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\\n\\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n"}]'},components:[{type:"htmlEditorComponent",content:"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Journal Article:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Article who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author. Co-Author: All other Authors of the Article besides the Corresponding Author. IntechOpen: IntechOpen Ltd., the Publisher of the Journal.
\n\nJournal: The publication as a collection of Articles compiled by IntechOpen .
\n\nArticle: The original literary work created by Corresponding Author and any Co Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\n\n3.2 When submitting the Article, the Corresponding Author agrees to:
\n\n• Comply with all instructions and guidelines provided by IntechOpen;
\n\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\n\n• Submit all the corrections in due time as defined during the publishing process schedule.
\n\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\n\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\n\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
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He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. 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His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. 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