Examples of Text-Hypothesis pairs from Recognizing Text Entailment Challenge.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"5382",leadTitle:null,fullTitle:"Cytoskeleton - Structure, Dynamics, Function and Disease",title:"Cytoskeleton",subtitle:"Structure, Dynamics, Function and Disease",reviewType:"peer-reviewed",abstract:"The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with \"motility\" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.",isbn:"978-953-51-3170-0",printIsbn:"978-953-51-3169-4",pdfIsbn:"978-953-51-4836-4",doi:"10.5772/62622",price:139,priceEur:155,priceUsd:179,slug:"cytoskeleton-structure-dynamics-function-and-disease",numberOfPages:342,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"f1c57584a4107ef50eefd39ceb1c8e64",bookSignature:"Jose C. Jimenez-Lopez",publishedDate:"May 17th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5382.jpg",numberOfDownloads:23198,numberOfWosCitations:32,numberOfCrossrefCitations:17,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:55,numberOfDimensionsCitationsByBook:4,hasAltmetrics:1,numberOfTotalCitations:104,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 16th 2016",dateEndSecondStepPublish:"April 6th 2016",dateEndThirdStepPublish:"July 11th 2016",dateEndFourthStepPublish:"October 9th 2016",dateEndFifthStepPublish:"November 8th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",biography:"Dr. Jose C. Jimenez-Lopez, BS. Biochemistry (1998), BS. Biological Sciences (2001), MS. Agricultural Sciences (2004), University of Granada, Spain; and Ph.D. Plant Cell Biology (2008) at CSIC. He was a Postdoctoral Research Associate at Purdue University, USA (2008-2011), and Marie Curie Research Fellow (EU - FP7) (2012-2015) at the University of Western Australia and CSIC. Currently, he is a Senior Research Fellow (Ramon y Cajal research program, 2016 - present), working in the functionality, health benefits, and molecular allergy aspects of seed proteins from crop species of agro-industrial interest (mainly legumes). He is the author of more than 65 journal articles, 29 book chapters, 2 patents, and more than 130 international congresses. He is an active member of different Scientific Societies and editor of multiple books.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"414",title:"Cytology",slug:"cytology"}],chapters:[{id:"54202",title:"Reorganization of Vegetal Cortex Microtubules and Its Role in Axis Induction in the Early Vertebrate Embryo",doi:"10.5772/66950",slug:"reorganization-of-vegetal-cortex-microtubules-and-its-role-in-axis-induction-in-the-early-vertebrate",totalDownloads:1330,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"In vertebrate species, induction of the embryonic axis is initiated by the transport of maternally supplied determinants, initially localized to the vegetal pole of the egg, toward the prospective organizer in the animal region. This transport process remains incompletely understood. Here, we review studies involving embryonic manipulations, visualization, and functional analysis of the cytoskeleton and loss- and gain-of-function conditions, which provide insights in this process. Transport of dorsal determinants requires cytoskeletal reorganization of a vegetal array of microtubules, microtubule motors, and an off-center movement of the vegetal cortex with respect to the inner egg core, a so-called cortical rotation. Additional mechanisms may be used in specific systems, such as a more general animally directed movement found in the teleost embryo. Initial polarity of the microtubule movement depends on early asymmetries, which are amplified by the movement of the outermost cortex. An interplay between microtubule organization and axis specification has also been reported in other animal species. Altogether, these studies show the importance of cytoskeletal dynamic changes, such as bundling, force-inducing motor activity, and regulated cytoskeletal growth, for the intracellular transport of maternally inherited factors to their site of action in the zygote.",signatures:"Elaine Welch and Francisco Pelegri",downloadPdfUrl:"/chapter/pdf-download/54202",previewPdfUrl:"/chapter/pdf-preview/54202",authors:[{id:"177209",title:"Prof.",name:"Francisco",surname:"Pelegri",slug:"francisco-pelegri",fullName:"Francisco Pelegri"},{id:"201614",title:"Dr.",name:"Elaine L.",surname:"Welch",slug:"elaine-l.-welch",fullName:"Elaine L. Welch"}],corrections:null},{id:"53714",title:"Actin-Microtubule Interaction in Plants",doi:"10.5772/66930",slug:"actin-microtubule-interaction-in-plants",totalDownloads:1676,totalCrossrefCites:1,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Interactions between actins and microtubules play an important role in many fundamental cellular processes in eukaryotes. Although several studies have shown actins and microtubules to be involved in specific cellular activities, little is known about how actins and microtubules contribute together to a given process. Preprophase band formation, which plays an essential role in plant division site determination, is a cellular process that lends itself to studies of actin-microtubule interactions and how they contribute to important cellular functions. Recently, we have analyzed microtubule-associated microfilaments during preprophase band formation in onion cotyledon epidermal cells using a combination of high-pressure freezing/freeze substitution and electron tomography. Quantitative analysis of our electron tomography data showed that relatively short single microfilaments form bridges between two adjacent microtubules in the process of narrowing of the preprophase microtubule band. Two types of microtubule-microfilament-microtubule connections are observed, and these microfilament-microtubule interactions suggest a direct role of F-actins in microtubule bundling. Based on these observations, we discuss how different actin-microtubule linkers might contribute to preprophase band narrowing and to other changes in microtubule organization in plant cells.",signatures:"Miyuki Takeuchi, L. Andrew Staehelin and Yoshinobu Mineyuki",downloadPdfUrl:"/chapter/pdf-download/53714",previewPdfUrl:"/chapter/pdf-preview/53714",authors:[{id:"146804",title:"Dr.",name:"Yoshinobu",surname:"Mineyuki",slug:"yoshinobu-mineyuki",fullName:"Yoshinobu Mineyuki"},{id:"148615",title:"Prof.",name:"Andrew",surname:"Staehelin",slug:"andrew-staehelin",fullName:"Andrew Staehelin"},{id:"189638",title:"Dr.",name:"Miyuki",surname:"Takeuchi",slug:"miyuki-takeuchi",fullName:"Miyuki Takeuchi"}],corrections:null},{id:"53734",title:"Morphological and Functional Aspects of Cytoskeleton of Trypanosomatids",doi:"10.5772/66859",slug:"morphological-and-functional-aspects-of-cytoskeleton-of-trypanosomatids",totalDownloads:1568,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Trypanosomatidae are protozoans that include monogenetic parasites, such as the Blastocrithidia and Herpetomonas genera, as well as digenetic parasites, such as the Trypanosoma and Leishmania genera. Their life cycles alternate between insect vectors and mammalian hosts. The parasite’s life cycle involves symmetrical division and different transitional developmental stages. In trypanosomatids, the cytoskeleton is composed of subpellicular microtubules organized in a highly ordered array of stable microtubules located beneath the plasma membrane, the paraflagellar rod, which is a lattice-like structure attached alongside the flagellar axoneme and a cytostome-cytopharynx. The complex life cycle, the extremely precise cytoskeletal organization and the single copy structures present in trypanosomatids provide interesting models for cell biology studies. The introduction of molecular biology, FIB/SEM (focused ion beam scanning electron microscopy) and electron microscopy tomography approaches and classical methods, such as negative staining, chemical fixation and ultrafast cryofixation have led to the determination of the three-dimensional (3D) structural organization of the cells. In this chapter, we highlight the recent findings on Trypanosomatidae cytoskeleton emphasizing their structural organization and the functional role of proteins involved in the biogenesis and duplication of cytoskeletal structures. The principal finding of this review is that all approaches listed above enhance our knowledge of trypanosomatids biology showing that cytoskeleton elements are essential to several important events throughout the protozoan life cycle.",signatures:"Juliana Cunha Vidal and Wanderley de Souza",downloadPdfUrl:"/chapter/pdf-download/53734",previewPdfUrl:"/chapter/pdf-preview/53734",authors:[{id:"161922",title:"Dr.",name:"Wanderley",surname:"De Souza",slug:"wanderley-de-souza",fullName:"Wanderley De Souza"},{id:"188230",title:"Dr.",name:"Juliana",surname:"Vidal",slug:"juliana-vidal",fullName:"Juliana Vidal"}],corrections:null},{id:"53526",title:"The Interplay between Cytoskeleton and Calcium Dynamics",doi:"10.5772/66862",slug:"the-interplay-between-cytoskeleton-and-calcium-dynamics",totalDownloads:1511,totalCrossrefCites:3,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Cell motility is a complex cellular event that involves reorganization of cytoskeleton. This reorganization encompasses the transient polarization of the cell to facilitate the plasma membrane ruffling, a rearrangement of cortical actin cytoskeleton required for the development of cellular protrusions. It is known that extracellular Ca2+ influx is essential for cell migration and for the positive-feedback cycle that maintains leading-edge structures and ruffling activity. The aim of this review is to summarize our knowledge regarding the Ca2+-dependent signaling pathways, Ca2+ transporters and sensors involved in cell migration. Also, we show here reported evidences that support for a crosstalk between Ca2+ transport and the reorganization of the cytoskeleton required for cell migration. In this regard, we will analyze the role of store-operated Ca2+ entry (SOCE) as a modulator of cytoskeleton and cell migration, but also the modulation of this Ca2+ entry pathway by microtubules and the actin cytoskeleton. As a main conclusion, this review will show that data reported in the last years support a role for SOCE in shaping cytoskeleton, but at the same time, SOCE is strongly dependent on cytoskeletal proteins, in an interesting interplay between cytoskeleton and Ca2+ dynamics.",signatures:"Francisco Javier Martin-Romero, Aida M. Lopez-Guerrero, Carlos\nPascual-Caro and Eulalia Pozo-Guisado",downloadPdfUrl:"/chapter/pdf-download/53526",previewPdfUrl:"/chapter/pdf-preview/53526",authors:[{id:"186585",title:"Dr.",name:"Francisco Javier",surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero"},{id:"186588",title:"Dr.",name:"Eulalia",surname:"Pozo-Guisado",slug:"eulalia-pozo-guisado",fullName:"Eulalia Pozo-Guisado"},{id:"186603",title:"Dr.",name:"Aida M.",surname:"Lopez-Guerrero",slug:"aida-m.-lopez-guerrero",fullName:"Aida M. Lopez-Guerrero"},{id:"186604",title:"Dr.",name:"Carlos",surname:"Pascual-Caro",slug:"carlos-pascual-caro",fullName:"Carlos Pascual-Caro"}],corrections:null},{id:"52365",title:"Role of Band 3 in the Erythrocyte Membrane Structural Changes Under Isotonic and Hypotonic Conditions",doi:"10.5772/64964",slug:"role-of-band-3-in-the-erythrocyte-membrane-structural-changes-under-isotonic-and-hypotonic-condition",totalDownloads:1203,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"An attempt was made to discuss and connect various modeling approaches which have been proposed in the literature in order to shed further light on the erythrocyte membrane relaxation under isotonic and hypotonic conditions. Roles of the main membrane constituents: (1) the actin‐spectrin cortex, (2) the lipid bilayer, and (3) the transmembrane protein band 3 and its course‐consequence relations were considered to estimate the membrane relaxation phenomena. Cell response to loading conditions includes the successive sub‐bioprocesses: (1) erythrocyte local or global deformation, (2) the cortex‐bilayer coupling, and (3) the rearrangements of band 3. The results indicate that the membrane structural changes include: (1) the spectrin flexibility distribution and (2) the rate of its changes influenced by the number of band 3 molecules attached to spectrin filaments, and phosphorylation of the actin‐spectrin junctions. Band 3 rearrangement also influences: (1) the effective bending modulus and (2) the band 3‐bilayer interaction energy and on that base the bilayer bending state. The erythrocyte swelling under hypotonic conditions influences the bilayer integrity which leads to the hemolytic hole formation. The hemolytic hole represents the excited cluster of band 3 molecules.",signatures:"Ivana Pajic‐Lijakovic and Milan Milivojevic",downloadPdfUrl:"/chapter/pdf-download/52365",previewPdfUrl:"/chapter/pdf-preview/52365",authors:[{id:"186758",title:"Dr.",name:"Ivana",surname:"Pajic-Lijakovic",slug:"ivana-pajic-lijakovic",fullName:"Ivana Pajic-Lijakovic"},{id:"193437",title:"Dr.",name:"Milan",surname:"Milivojevic",slug:"milan-milivojevic",fullName:"Milan Milivojevic"}],corrections:null},{id:"53565",title:"Dystrophin–Glycoprotein Complex in Blood Cells",doi:"10.5772/66857",slug:"dystrophin-glycoprotein-complex-in-blood-cells",totalDownloads:1026,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The Dystrophin-Associated Protein Complex (DAPC), known as the Dystrophin–Glycoprotein Complex (DGC), comprises an array of glycoproteins that are essential for the normal function of striated muscle, in which they were first described, and for many other tissues, including blood. Understanding the role that these molecules play in muscle function has increased over the last decade, and some of the knowledge derived can be applied to other biological systems. However, there is no doubt that to date, some progress has been achieved in blood cells.",signatures:"Doris Cerecedo",downloadPdfUrl:"/chapter/pdf-download/53565",previewPdfUrl:"/chapter/pdf-preview/53565",authors:[{id:"101372",title:"Dr.",name:"Doris",surname:"Cerecedo",slug:"doris-cerecedo",fullName:"Doris Cerecedo"}],corrections:null},{id:"53560",title:"Biophysics of Fish Sperm Flagellar Movement: Present Knowledge and Original Directions",doi:"10.5772/66863",slug:"biophysics-of-fish-sperm-flagellar-movement-present-knowledge-and-original-directions",totalDownloads:1481,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"A fish spermatozoon has a minimalist structure: head, mid-piece and flagellum with the active inner core, called “axoneme”. The axoneme represents a cylindrical scaffold of microtubular doublets arranged around a pair of single microtubules and assorted along the entire length with the dynein-ATPase motors. The mechanisms of wave generation along the flagellum becomes possible due to sliding of microtubules relative to each other and their propagation is a result of a balance between mechanical constraints and intra-flagellar biochemical actors that generate force.",signatures:"Galina Prokopchuk and Jacky Cosson",downloadPdfUrl:"/chapter/pdf-download/53560",previewPdfUrl:"/chapter/pdf-preview/53560",authors:[{id:"187828",title:"Dr.",name:"Galina",surname:"Prokopchuk",slug:"galina-prokopchuk",fullName:"Galina Prokopchuk"},{id:"188281",title:"Dr.",name:"Jacky",surname:"Cosson",slug:"jacky-cosson",fullName:"Jacky Cosson"}],corrections:null},{id:"53382",title:"Cytoskeleton Rearrangements during the Execution Phase of Apoptosis",doi:"10.5772/66865",slug:"cytoskeleton-rearrangements-during-the-execution-phase-of-apoptosis",totalDownloads:1531,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Apoptosis is a regulated energy‐dependent process for the elimination of unnecessary or damaged cells during embryonic development, tissue homeostasis and many pathological conditions. Apoptosis is characterized by specific morphological and biochemical features in which caspase activation has a pivotal role. During apoptosis, cells undergo characteristic morphological reorganizations in which the cytoskeleton participates actively. Traditionally, this cytoskeleton rearrangement has been assigned mainly to actinomyosin ring contraction, with microtubule and intermediate filaments both reported to be depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reformed during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Current hypothesis proposes that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis. AMN disruption provokes apoptotic cell collapse, secondary necrosis and the subsequent release of toxic molecules which can damage surrounding cells and promote inflammation. Therefore, AMN formation in physiological or pathological apoptosis is essential for tissue homeostasis.",signatures:"Jesús Porcuna Doncel, Patricia de la Cruz Ojeda, Manuel OropesaÁvila,\nMarina Villanueva Paz, Isabel De Lavera, Mario De La Mata,\nMónica Álvarez Córdoba, Raquel Luzón Hidalgo, Juan Miguel\nSuarez Rivero, David Cotán and José Antonio Sánchez‐Alcázar",downloadPdfUrl:"/chapter/pdf-download/53382",previewPdfUrl:"/chapter/pdf-preview/53382",authors:[{id:"77267",title:"Dr.",name:"José Antonio",surname:"Sánchez-Alcázar",slug:"jose-antonio-sanchez-alcazar",fullName:"José Antonio Sánchez-Alcázar"},{id:"175111",title:"Dr.",name:"Manuel",surname:"Oropesa Ávila",slug:"manuel-oropesa-avila",fullName:"Manuel Oropesa Ávila"},{id:"175112",title:"Dr.",name:"David",surname:"Cotán",slug:"david-cotan",fullName:"David Cotán"},{id:"175113",title:"Mr.",name:"Mario",surname:"De La Mata",slug:"mario-de-la-mata",fullName:"Mario De La Mata"},{id:"175114",title:"Ms.",name:"Marina",surname:"Villanueva Paz",slug:"marina-villanueva-paz",fullName:"Marina Villanueva Paz"},{id:"175116",title:"Ms.",name:"Isabel",surname:"De Lavera",slug:"isabel-de-lavera",fullName:"Isabel De Lavera"},{id:"175757",title:"Ms.",name:"Mónica",surname:"Álvarez Córdoba",slug:"monica-alvarez-cordoba",fullName:"Mónica Álvarez Córdoba"},{id:"194503",title:"M.Sc.",name:"Jesús",surname:"Porcuna Doncel",slug:"jesus-porcuna-doncel",fullName:"Jesús Porcuna Doncel"},{id:"194504",title:"BSc.",name:"Patricia",surname:"De La Cruz Ojeda",slug:"patricia-de-la-cruz-ojeda",fullName:"Patricia De La Cruz Ojeda"},{id:"194505",title:"BSc.",name:"Raquel",surname:"Luzón Hidalgo",slug:"raquel-luzon-hidalgo",fullName:"Raquel Luzón Hidalgo"},{id:"194506",title:"BSc.",name:"Juan Miguel",surname:"Suarez Rivero",slug:"juan-miguel-suarez-rivero",fullName:"Juan Miguel Suarez Rivero"}],corrections:null},{id:"54949",title:"How are Dynamic Microtubules Stably Tethered to Human Chromosomes?",doi:"10.5772/intechopen.68321",slug:"how-are-dynamic-microtubules-stably-tethered-to-human-chromosomes-",totalDownloads:1436,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:1,abstract:"During cell division, microtubules capture and pull chromosomes apart into two equal sets. Without the establishment of proper chromosome-microtubule attachment, microtubules cannot impart the pulling forces needed to separate sister chromatid pairs. How are chromosomes captured along microtubule walls? How is the attachment of chromosomes to dynamic microtubule-ends achieved and monitored? We discuss these key questions by considering the roles of kinetochore-bound microtubule regulating proteins and also the complex regulatory loops of kinases and phosphatases that control chromosome-microtubule attachment and ensure the accurate segregation of chromosomes.",signatures:"Duccio Conti, Madeleine Hart, Naoka Tamura, Roshan Shrestha,\nAsifa Islam and Viji M. Draviam",downloadPdfUrl:"/chapter/pdf-download/54949",previewPdfUrl:"/chapter/pdf-preview/54949",authors:[{id:"188482",title:"Dr.",name:"Viji",surname:"Draviam",slug:"viji-draviam",fullName:"Viji Draviam"},{id:"206119",title:"Ph.D. Student",name:"Madeleine",surname:"Hart",slug:"madeleine-hart",fullName:"Madeleine Hart"},{id:"206120",title:"Dr.",name:"Duccio",surname:"Conti",slug:"duccio-conti",fullName:"Duccio Conti"},{id:"206121",title:"Dr.",name:"Roshan",surname:"Shrestha",slug:"roshan-shrestha",fullName:"Roshan Shrestha"},{id:"206122",title:"Dr.",name:"Asifa",surname:"Islam",slug:"asifa-islam",fullName:"Asifa Islam"},{id:"206123",title:"Dr.",name:"Naoka",surname:"Tamura",slug:"naoka-tamura",fullName:"Naoka Tamura"}],corrections:null},{id:"54157",title:"Muscle Fibers Lacking Desmin in the Extraocular Muscles: A Paradigm Shift",doi:"10.5772/66928",slug:"muscle-fibers-lacking-desmin-in-the-extraocular-muscles-a-paradigm-shift",totalDownloads:1059,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The extraocular muscles are highly specialized muscles responsible for the complex movements of the eyeball. They differ from other skeletal muscles in many respects, including fundamental components of the contractile apparatus and the extracellular matrix. Using immunohistochemistry and a battery of well-characterized antibodies, we have investigated the composition of the cytoskeleton of their myofibers with respect to desmin, vimentin, and nestin. In the adult and fetal human extraocular muscles, a subgroup of the slow tonic muscle fibers is lacking desmin. These fibers, which are multiply innervated, show a normal myofibrillar arrangement, maintained mitochondrial distribution, and sarcolemma integrity. Desmin, the most abundant intermediate filament protein in muscle, has been considered a ubiquitous protein in skeletal muscle fibers where it links adjacent myofibrils and the myofibrillar network to the sarcolemma, the mitochondria and the membrane of the nuclei. The functional implications of the lack of desmin remain to be determined, but these findings represent a paradigm shift, as desmin has been regarded a ubiquitous protein of the cytoskeleton of muscle fibers.",signatures:"Fatima Pedrosa Domellöf",downloadPdfUrl:"/chapter/pdf-download/54157",previewPdfUrl:"/chapter/pdf-preview/54157",authors:[{id:"188144",title:"Prof.",name:"Fatima",surname:"Pedrosa Domellöf",slug:"fatima-pedrosa-domellof",fullName:"Fatima Pedrosa Domellöf"}],corrections:null},{id:"53586",title:"The Actomyosin Network and Cellular Motility: A S100A4 Regulatory View into the Process",doi:"10.5772/66940",slug:"the-actomyosin-network-and-cellular-motility-a-s100a4-regulatory-view-into-the-process",totalDownloads:1343,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cell migration is a fundamental process responsible for numerous physiological and physiopathological conditions such as inflammation, embryogenesis and cancer. This central aspect of cell biology has seen quantum leaps in our understanding of the coordinated regulations, both spatial and temporal of numerous cytoskeletal proteins and their orchestrations. At the molecular level, this dynamic cellular process can be naively summarised as an engineered cycle composed of three distinct phases of (1) formation of cellular protrusion to initiate contact followed by (2) the adhesion with the external environment/cell-extracellular established connection and (3) the actomyosin force generation to consequently remodel the cytoskeleton. A prominent factor that regulates cellular motility is S100A4, a protein that has received constant attention for its significant role in cellular migration. Consequently, and in order to focus further the impact of this work, the present chapter aims to review some of the actomyosin proteins/complexes that have been demonstrated to be crucial players of the cyclic migration process but are also S100A4 interactors. In doing so, this chapter aims to capture a picture of how expression of this small, calcium-binding protein may, in essence, remodel at different levels the actin organisation and fulfil the motility engineered cycle of protrusion, attachments and contractions.",signatures:"Stephane R. Gross",downloadPdfUrl:"/chapter/pdf-download/53586",previewPdfUrl:"/chapter/pdf-preview/53586",authors:[{id:"187744",title:"Dr.",name:"Stephane",surname:"Gross",slug:"stephane-gross",fullName:"Stephane Gross"}],corrections:null},{id:"53691",title:"Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity",doi:"10.5772/66926",slug:"intermediate-filaments-as-a-target-of-signaling-mechanisms-in-neurotoxicity",totalDownloads:1265,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In this chapter, we deal with the current knowledge and important results on the cytoskeletal proteins and their differential regulation by kinases/phosphatases and Ca2+‐mediated mechanisms in developmental rat brain. We focus on the misregulation of the phosphorylating system associated with intermediate filament proteins of neural cells and its relevance to cell and tissue dysfunction. Taking into account our findings, we propose that intermediate‐filament proteins are dynamic structures whose regulation is crucial for proper neural cell function. Given their relevance, they must be regulated in response to extracellular and intracellular signals. The complexity and connection between signaling pathways regulating intermediate‐filament dynamics remain obscure. In this chapter, we get light into some kinase/phosphatase cascades downstream of membrane receptors disrupting the dynamics of intermediate filaments and its association with neural dysfunction. However, intermediate filaments do not act individually into the neural cells. Our results evidence the importance of misregulated cytoskeletal crosstalk in disrupting cytoskeletal dynamics and cell morphology underlying neural dysfunction in experimental conditions mimicking metabolic diseases and nongenomic actions of thyroid hormones and as an end point in the neurotoxicity of organic tellurium.",signatures:"Ariane Zamoner and Regina Pessoa-Pureur",downloadPdfUrl:"/chapter/pdf-download/53691",previewPdfUrl:"/chapter/pdf-preview/53691",authors:[{id:"186612",title:"Dr.",name:"Regina",surname:"Pessoa-Pureur",slug:"regina-pessoa-pureur",fullName:"Regina Pessoa-Pureur"},{id:"187776",title:"Dr.",name:"Ariane",surname:"Zamoner",slug:"ariane-zamoner",fullName:"Ariane Zamoner"}],corrections:null},{id:"53572",title:"Acting on Actin During Bacterial Infection",doi:"10.5772/66861",slug:"acting-on-actin-during-bacterial-infection",totalDownloads:1658,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Bacterial resistance to antibiotics is becoming a major threat to public health. It is imperative to find new therapeutic interventions to fight pathogens. Thus, deciphering host-pathogen interactions may allow defining targets for new strategies for effective treatments of infectious diseases. This chapter focuses on the bacterial manipulation of the host cell actin cytoskeleton. We discuss three infectious processes. The first is pathogen establishment of infection/invasion, explaining cellular uptake pathways that rely on actin, such as phagocytosis and macropinocytosis. The second process focus on the establishment of a replication niche, a process that subverts cytoskeletal functions associated with membrane trafficking namely phagosome maturation and cellular innate immune responses. Finally, pathogen dissemination is an emerging field that microfilaments have shown to participate: pathogen motility through the cytoplasm and from cell-to-cell or on the outer surface of the plasma membrane mimicking a receptor tyrosine kinase signaling pathway that helps the projection of pathogens to neighboring cells. It also establishes a connection with the innate immunity related with induction of cell signaling to inflammation, inflammasome activation, and programmed cell death. These studies revealed several potential targets related to actin cytoskeleton manipulation to design new therapeutic strategies for bacterial infections.",signatures:"Elsa Anes",downloadPdfUrl:"/chapter/pdf-download/53572",previewPdfUrl:"/chapter/pdf-preview/53572",authors:[{id:"78473",title:"Prof.",name:"Elsa",surname:"Anes",slug:"elsa-anes",fullName:"Elsa Anes"}],corrections:null},{id:"53624",title:"Heterotrimeric G Proteins and the Regulation of Microtubule Assembly",doi:"10.5772/66929",slug:"heterotrimeric-g-proteins-and-the-regulation-of-microtubule-assembly",totalDownloads:1505,totalCrossrefCites:0,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Microtubules (MTs), a major component of cell cytoskeleton, exhibit diverse cellular functions including cell motility, intracellular transport, cell division, and differentiation. These functions of MTs are critically dependent on their ability to polymerize and depolymerize. Although a significant progress has been made in identifying cellular factors that regulate microtubule assembly and dynamics, the role of signal transducing molecules in this process is not well understood. It has been demonstrated that heterotrimeric G proteins, which are components of G protein-coupled receptor (GPCR) signaling pathway, interact with microtubules and play important roles in regulating assembly/dynamics of this cytoskeletal filament. While α subunit of G proteins (Gα) inhibits microtubule assembly and accelerates microtubule dynamics, Gβγ promotes tubulin polymerization. In this chapter, we review the current status of G-protein modulation of microtubules and cellular and physiological aspects of this regulation. Molecular, biochemical, and cellular methodologies that have been used to advance this field of research are discussed. Emphasis has been given on G-protein-microtubule interaction in neuronal differentiation as significant progress has been made in this field. The outcome from this research reflects the importance of GPCRs in transducing extracellular signals to regulate a variety of microtubule-associated cellular events.",signatures:"Sukla Roychowdhury and Jorge A. Sierra-Fonseca",downloadPdfUrl:"/chapter/pdf-download/53624",previewPdfUrl:"/chapter/pdf-preview/53624",authors:[{id:"187126",title:"Dr.",name:"Sukla",surname:"Roychowdhury",slug:"sukla-roychowdhury",fullName:"Sukla Roychowdhury"},{id:"196958",title:"Dr.",name:"Jorge",surname:"Sierra-Fonseca",slug:"jorge-sierra-fonseca",fullName:"Jorge Sierra-Fonseca"}],corrections:null},{id:"53708",title:"Novel Insights into the Role of the Cytoskeleton in Cancer",doi:"10.5772/66860",slug:"novel-insights-into-the-role-of-the-cytoskeleton-in-cancer",totalDownloads:2124,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:1,abstract:"The cytoskeleton is a complex network of highly ordered intracellular filaments that plays a central role in controlling cell shape, division, functions, and interactions in human organs and tissues, but dysregulation of this network can contribute to numerous human diseases, including cancer. To clarify the various functions of the cytoskeleton and its role in cancer progression, in this chapter, we will discuss the microfilament (actin cytoskeleton), microtubule (β‐tubulin), and intermediate filament (keratins, cytokeratins, vimentin, and lamins) cytoskeletal structures; analyze the physiological functions of the cytoskeleton and its regulation of cell differentiation; and investigate the roles of the cytoskeleton in cancer progression, the epithelial‐mesenchymal transition process (EMT), and the mechanisms of multidrug resistance (MDR) in relation to the cytoskeleton. Importantly, the cytoskeleton, as a key regulator of the transcription and expression of many genes, is known to be involved in various physiological and pathological processes, which makes the cytoskeleton a novel and highly effective target for assessing the response to antitumor therapy in cancer.",signatures:"Xuan Zhang, Zenglin Pei, Chunxia Ji, Xiaoyan Zhang, Jianqing Xu\nand Jin Wang",downloadPdfUrl:"/chapter/pdf-download/53708",previewPdfUrl:"/chapter/pdf-preview/53708",authors:[{id:"188127",title:"Prof.",name:"Jin",surname:"Wang",slug:"jin-wang",fullName:"Jin Wang"},{id:"194290",title:"Ms.",name:"Xuan",surname:"Zhang",slug:"xuan-zhang",fullName:"Xuan Zhang"},{id:"194291",title:"Dr.",name:"Zenglin",surname:"Pei",slug:"zenglin-pei",fullName:"Zenglin Pei"},{id:"194292",title:"Ms.",name:"Chunxia",surname:"Ji",slug:"chunxia-ji",fullName:"Chunxia Ji"},{id:"194293",title:"Prof.",name:"Xiaoyan",surname:"Zhang",slug:"xiaoyan-zhang",fullName:"Xiaoyan Zhang"},{id:"194294",title:"Prof.",name:"Jianqing",surname:"Xu",slug:"jianqing-xu",fullName:"Jianqing Xu"}],corrections:null},{id:"53741",title:"Targeting the Cytoskeleton with Plant-Bioactive Compounds in Cancer Therapy",doi:"10.5772/66911",slug:"targeting-the-cytoskeleton-with-plant-bioactive-compounds-in-cancer-therapy",totalDownloads:1486,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"In this overview we describe the main plant-derived bioactive compounds used in cancer therapy which has the cell cytoskeleton as therapeutic target. Three major classes of these compounds are described: antimitotics with microtubule-destabilizing and—stabilizing effects, plant-bioactive compounds that interact with intermediate filaments/actin, and plant-bioactive compounds that interact with intermediate filaments like keratins and vimentin. We also focus on the molecular aspects of interactions with their cellular targets: microtubules, intermediate filaments, and microfilaments. Some critical aspects of cardiac side effects of cancer chemotherapy are also discussed, focusing on cardiac cytoskeleton and protective effect of plant-derived compounds. The application of plant bioactives in the treatment of cancer has resulted in increased therapeutic efficacy through targeting the cytoskeleton, respectively, prevention of the injury of cytoskeletal components elicited by chemotherapeutics.",signatures:"Anca Hermenean and Aurel Ardelean",downloadPdfUrl:"/chapter/pdf-download/53741",previewPdfUrl:"/chapter/pdf-preview/53741",authors:[{id:"174395",title:"Prof.",name:"Aurel",surname:"Ardelean",slug:"aurel-ardelean",fullName:"Aurel Ardelean"},{id:"179323",title:"Prof.",name:"Anca",surname:"Hermenean",slug:"anca-hermenean",fullName:"Anca Hermenean"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6096",title:"Seed Biology",subtitle:null,isOpenForSubmission:!1,hash:"0929ebc410ef5c25efdf938e3d34b6b2",slug:"advances-in-seed-biology",bookSignature:"Jose C. 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Recent Advances, New Perspectives and Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThe book "Silver nanoparticles" is proposed to provide the current state-of-the-art synthesis, characterization techniques, properties, and applications of silver nanoparticles and their nanocomposite materials. The articles covered in the book would be experimental research papers, reviews, or minireviews addressing different synthesis methods of silver nanoparticles such as chemical, physical, biological/ green methods, microwave methods, and recent advancements in their characterization techniques. Another important aspect covered would be toxicity evaluation and the health impacts of silver nanoparticles. A broader insight would be provided on the applications of silver nanoparticles in wound healing, tissue engineering, drug delivery, cancer diagnosis, antimicrobial surfaces, corrosion protective coatings, regenerative medicine, therapeutic applications, and others. Biopolymer nanocomposites such as starch, chitosan, cellulose, and others reinforced with silver nanoparticles can also be included. The book would be targeting students, scientists, and researchers, from academia and industry interested in nanoscience and technology of biopolymers, biomedical and tissue engineering, and nanomedicine.
",isbn:"978-1-80356-744-0",printIsbn:"978-1-80356-743-3",pdfIsbn:"978-1-80356-745-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"eadac73f609da20167ba128e077b1669",bookSignature:"Dr. Eram Sharmin",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11463.jpg",keywords:"Silver Nanoparticles, Chemical Synthesis, Electrochemical Synthesis, Physical Synthesis, Nanocomposite Hydrogels, Silver Scaffolds, Ointments, Creams, Biopolymer Nanocomposites, Nanoparticles, Coatings, Bioactive",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 24th 2022",dateEndSecondStepPublish:"April 21st 2022",dateEndThirdStepPublish:"June 20th 2022",dateEndFourthStepPublish:"September 8th 2022",dateEndFifthStepPublish:"November 7th 2022",remainingDaysToSecondStep:"a month",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:'Dr. Eram Sharmin obtained her Ph.D. degree in Chemistry from Jamia Millia Islamia (JMI) - A Central University, India. She has more than 50 publications in peer-reviewed journals and books and has presented more than 30 research papers in national and international conferences. Her research interests include the development of "green” materials with applications such as antimicrobial and protective coatings, films, hydrogels, and packaging materials.',coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"107375",title:"Dr.",name:"Eram",middleName:null,surname:"Sharmin",slug:"eram-sharmin",fullName:"Eram Sharmin",profilePictureURL:"https://mts.intechopen.com/storage/users/107375/images/system/107375.jpeg",biography:'Dr. Eram Sharmin is an Associate Professor at the Department of Pharmaceutical Chemistry, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. She obtained her Ph.D. degree in Chemistry from Jamia Millia Islamia (JMI) - A Central University, New Delhi, India, in the year 2007. She received her MSc degree in Organic Chemistry, in the year 2000, and BSc degree in Chemistry, in the year 1998, from Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh (UP), India. She has previously worked as Senior Research Associate [Under Scientists’ Pool Scheme, Council of Scientific and Industrial Research (CSIR), New Delhi, India], Research Associate (CSIR, New Delhi), and Senior Research Fellow (CSIR, New Delhi), at Materials Research Laboratory, Department of Chemistry, JMI. She has more than 50 publications in peer-reviewed journals and books and has presented more than 30 research papers in national and international conferences. 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From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"6935",title:"Information Extraction from Text – Dealing with Imprecise Data",doi:"10.5772/7223",slug:"information-extraction-from-text-dealing-with-imprecise-data",body:'\n\t\tInformation Extraction from text is a special case of Data Mining where one extracts valuable information from unstructured documents. On the other hand, soft computing approaches, e.g., neural networks, fuzzy systems, deal with information processing. An architecture that can combine these processes into a complete system has been the top research field in computer and information sciences for the last decade. In this paper we will present novel methods for information processing, which can model imprecision in a given database that classical bivalent methods cannot handle. Specifically we will present novel approaches on developing soft models via function representations in place of rule based methods. We will present examples on more intelligent applications of information extraction from text and compare the performance of the novel approaches to the state-of-the-art learning methods on this field.
\n\t\t\tThere have been vast amount of work on information processing, which keeps us listing them all in here. Since the aim of this chapter is to present novel approaches on information processing via fuzzy functions and their extensions, we will start with the related work on functional analysis on information processing. Later in section 3, we introduce the framework of fuzzy system modelling with fuzzy functions followed by extensions of fuzzy functions under uncertainties in section 4. Specifically, we present various fuzzy system modelling approaches via higher order fuzzy sets, e.g., interval-valued type-2 and full type-2 fuzzy modelling. Section 5 presents possible applications of the latter novel approaches on information extraction from text. In section 6 we present the results of this study and discussions for future research. Finally, in section 7 we draw conclusions.
\n\t\tLet us first briefly review the literature to expose a historical account of “fuzzy function?” in a variety of approaches by several authors.
\n\t\t\tOriginally, "Fuzzy Functions" were defined in (Bandler & Grinder, 1976) as a connecting or overlapping of our sensory representational systems. Technically, Bandler and Grinder define "fuzzy functions" as:
\n\t\t\t\n\t\t\t\t
Later we find certain articles in the literature, for example, (Sasaki, 1993) and (Demirci, 1999), etc…
\n\t\t\t\n\t\t\t\tTurksen (2006) first introduced “Fuzzy Functions” unaware of the publications stated above and published “Fuzzy Functions with LSE” (Turksen, 2008) which is quite different in structure and intent from Sasaki and Demirci expositions. Later “Fuzzy Functions” were further developed in a variety of directions in (Celikyilmaz & Turksen, 2007; 2008a-g; 2009a-d; Turksen & Celikyilmaz, 2006).
\n\t\t\tWith this perspective, Fuzzy Functions, for short, FF, are proposed for the structure identification of system models and reasoning with them. These fuzzy functions can be determined by any function identification method such as least squares’ estimates, LSE, maximum likelihood estimates, MLE, support vector machine estimates, SVM (Gunn, 1998) etc. Furthermore, our work extends to Type 2 Fuzzy Functions which incorporates the parameter uncertainties in system modelling.
\n\t\tTraditional FIS structure is based on the fuzzy rule base (FRB) (
In (1) each
In (2)
The traditional FIS structures presented above have various challenges that should not be neglected (Turksen & Celikyilmaz, 2006). Among some of these challenges are identification of the; types of antecedent and consequent membership functions, and their varying parameters, most suitable combination operators (t-norm, t-conorm, etc.), conjunction operators during aggregation of antecedents, and consequents, implication operator types to capture uncertainty associated with the linguistic “AND”, “OR”, “IMP” for the representation of the rules, and reasoning with them, type of defuzzification method, etc.
\n\t\t\t\tThe literature indicates that a given FIS model performance can be slightly affected by the change in t-norm values. Nevertheless, one still needs to decide the type of t-norm and t-conorm operators. Over the course of many years these challenges have been investigated to reduce the fuzzy operations (Babuska & Verbruggen, 1997), and expert intervention and many different methods are proposed such as building hybrid fuzzy systems using other soft computing methods via genetic algorithms or neural networks, etc.
\n\t\t\t\tSome extensions of traditional FISs e.g., (Uncu et.al., 2004), assume that antecedent fuzzy sets are dependent on each other (interactive), so in these systems an entire antecedent part of a given rule is represented with a single type-1 fuzzy set. Such FIS structures are expressed as follows:
\n\t\t\t\tIn (3) the fuzzy set
Later, the performance of latter systems is improved with the implementation of improved fuzzy functions algorithm (\n\t\t\t\t\t\tCelikyilmaz & Turksen, 2008\n\t\t\t\t\t\ta-g). Next subsection briefly reviews such systems, which forms the basis of the Type-2 Fuzzy Functions.
\n\t\t\tAlthough FSM approach based on Fuzzy Functions in Fig. 1 and traditional FSM approaches based on FRB structures (Takagi & Sugeno, 1985; Emami et.al. 1998; Bodur et al., etc.) share similar system design steps, they differ in structure identification, namely in finding the fuzzy models (rules) for each pattern identified. The new FFs approach first clusters a given data into several overlapping fuzzy clusters, each of which is used to define a separate decision rule. Fuzzy c-means clustering (FCM) (Bezdek, 1984) has been the main clustering algorithm utilized in these methods to find fuzzy partitions so far. The novelty of the FFs approaches are that, during structure identification, similarity of the objects are enhanced with additional fuzzy identifiers viz. membership values, by utilizing them as additional predictors of the system model along with the original input variables to estimate the local relations of the input-output data. Thus, membership values and their list of possible (user-defined) transformations are augmented to original dataset as new dimensions to structure different representations for each cluster.
\n\t\t\t\tFramework of fuzzy system models with fuzzy functions approach.
In (\n\t\t\t\t\t\tCelikyilmaz & Turksen, 2008b) a new fuzzy clustering algorithm is proposed, namely Improved Fuzzy Clustering (IFC) algorithm, which carries out two objectives: (i) to find good representation of the partition matrix, which captures the multiple model structure of the given system by identifying the hidden patterns, (ii) to find the membership values, which are good predictors of the regression models of each cluster. Therefore the objective function of the new IFC is designed based on these two objectives. The novelty of the presented fuzzy clustering approach, which aparts itself from the earlier improved fuzzy clustering approaches by (Chen et al. 1998; Höppner & Klawonn, 2003; Menard, 2001) is that, during IFC optimization, regression models, to be build for each cluster, will use only membership values measured at a particular iteration and their user defined transformations, but not the original input variables. Alienating original input variables and building regression models with membership values will shape the memberships into candidate inputs to explain the output variable for each local model. As a result of this improvement, the new IFC introduces a new membership function. In the proposed IFC, we hypothesize to find membership values that can increase the prediction power of the system modeling with FFs. In this sense, the resulting fuzzy functions are referred as “improved fuzzy functions (IFF)”.
\n\t\t\t\tFlow chart of Fuzzy System Models with Fuzzy Functions Approach.
Structure identification of FIS with Fuzzy Functions Systems is based on Improved Fuzzy Clustering (IFC) algorithm to identify the hidden structures in a given dataset. The learning algorithm is sketched in Fig.2.
\n\t\t\t\tThe type-1 FIS with Improved Fuzzy Functions (Celikyilmaz & Turksen, 2007, 2008b) is designed to eliminate most of the aforementioned fuzzy operations of traditional type-1 FIS. In somewhat simplified view, such fuzzy systems work as follows:
\n\t\t\t\tThe domain
To each of these regions a local fuzzy model
Let (xk,yk) denote each training data point, where xk(x1,k…xnv,k), is the kth input vector of nv dimensions, yk, is their output value, µik∈[0,1] represent the membership value of kth vector to cluster i=1…c, c be the total number of clusters, m, be the level of fuzziness parameter. The learning algorithm of type-1 FIS with the Improved Fuzzy Functions approach (Celikyilmaz & Turksen, 2007; 2008b;c) is processed as follows:
\n\t\t\t\t\n\t\t\t\t\t
In (4), dik=||xk-vi||, represents the Euclidean distance of each xk to each cluster center, vi. The error Eik=(yk-gi(τik))2 is the total squared deviation between of the approximated fuzzy models, namely the interim fuzzy functions, gi(τi) of cluster i and the actual output. The novelty of each gi(τi) is that corresponding membership values and their possible transformations are the only predictors of interim fuzzy functions, while excluding original variables. The aim is to calculate the membership values that can be candidate input variables when used to estimate the local models. An example interim fuzzy function can be formed using:
\n\t\t\t\tIn (5), ŵi represents the vector of regression coefficients. IFC minimizes the objective function, Jm\n\t\t\t\t\tIFC. The second term of the objective function can be minimized if optimum functions can be found. Thus, the algorithm searches for the best interim fuzzy functions, gi(τi).
\n\t\t\t\tFrom the Lagrange transformation of the objective function in (4) the membership values are calculated with a new membership value update equation as follows,
\n\t\t\t\t\n\t\t\t\t\t
Proposed IFC optimization method searches for optimum membership values, which are to be used later as additional predictors to estimate parameters of Fuzzy Functions of a given system model. The structures of functions to be approximated depend on distribution of membership values with an output variable. One should choose appropriate membership value transformations to approximate output variable. For any given fuzzifier m and number of clusters c the outputs of the IFC algorithm are as follows:
\n\t\t\t\toptimum parameters of fuzzy functions f(τi) of each cluster ŵi, i=1…c, that are captured from the last iteration step,
structure of the input matrix, τi, viz. the list of different types of membership value transformations that are used to approximate each f(τi) during IFC,
optimized membership matrix, U*(x,y), the cluster centers v*(x,y)
(*) indicates the optimum results from the new IFC algorithm.
\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t
The interim fuzzy functions, gi(τi) are different from principle fuzzy functions \n\t\t\t\t\t
\n\t\t\t\t\t
In (7) vc* represents the compactness and vs* represents the separability. vc* combines within-cluster distances and errors between actual and estimated output obtained from c number of principle fuzzy functions. The vi and vj i,j=1,..,c, i≠j represent the cluster center vectors of two separate clusters of an IFC model. vs* determines the structure of clusters by measuring the ratio of cluster center distances to the angle between their regression functions. The αi in the |αi,αj|∈[0,1], i,j=1,…,c, is the unit normal vector of each principle fuzzy function i, \n\t\t\t\t\t
Any regression approximation method can be employed to identify the parameters of local functions, e.g. LSE or soft computing approaches such as neural networks or support vector machines (SVM) (Gunn, 1998). For instance, when LSE is used to identify the local models of a cluster i, the principle fuzzy function is formed with function as:
\n\t\t\t\t\n\t\t\t\t\t
The experiments indicate that the FIS system based on Fuzzy Functions (Turksen, 2008; \n\t\t\t\t\t\tCelikyilmaz & Turksen, 2008\n\t\t\t\t\t\ta) outperform traditional type-1 FIS as well as other soft computing approaches. One of the issues of this approach is that since type-1 fuzzy sets are implemented, it may not be possible to handle uncertainties. In particular, there is also the uncertainty in determining the system parameters such as; type of membership value transformations (τi) used during IFC algorithm (such as in (5)) and during shaping principle fuzzy functions, \n\t\t\t\t\t
The type-2 fuzzy sets can handle the numerical uncertainties in inputs and outputs of fuzzy functions,
The uncertainty in determining the type, and parameters of membership value extraction functions are managed,
The type-2 fuzzy sets are discretisized into a large number of embedded type-1 fuzzy sets, which enable a wealthy environment to describe the local input-output relations.
The new type-2 FIS based on Fuzzy Functions is designed that can characterize structure of optimum membership value transformations Ω={τi,Фi} of given fuzzy function, the shape of membership values, the number and type of fuzzy function structures, and number of local structures. In summary, the proposed approach searches for the optimum uncertainty interval of membership functions and optimum list of the fuzzy function structures for each local model using soft computing approaches such as genetic algorithms.
\n\t\t\tBefore we present the new type-2 FIS based on Fuzzy Functions, we briefly review the traditional type-2 FISs. For the generalized type-2 case, where the secondary membership functions, the third dimension, are of any type, there is a significant computational complexity that has delayed their development (Coupland & John, 2007). Thus, in most type-2 fuzzy logic research, the interval type-2 fuzzy sets are. Nonetheless, recent investigations on full type-2 fuzzy logic systems such as (Coupland & John, 2007) or (\n\t\t\t\t\t\tCelikyilmaz & Turksen, 2008c) present promising results.
\n\t\t\t\tA type-2 fuzzy set à is characterized by a type-2 membership function μÃ(x,u), where x∈X and u∈Jx⊆[0,1], i.e.,
\n\t\t\t\tThe elements of the domain of
The interval fuzzy logic systems are embedded type-1 fuzzy inference systems, which implement fuzzy sets, Ã. In (10) Jx is a set of real values with finite elements. A special case of interval-valued type-2 FIS is formalized with the fuzzy sets of discrete domain as follows:
\n\t\t\t\tIn (11), the membership functions are discretisized and are used to form a collection of embedded type-1 FIS. Hence, ith rule in a type-2 system having nv inputs x1∈X1…xnv∈Xnv and one output y∈Y is represented with;
\n\t\t\t\tThe uncertainty in primary membership functions of a type-2 fuzzy set Ã, is represented with a bounded region that is called the foot-print of uncertainty (FOU). It is the union of all the primary membership functions. With the implementation of type-2 fuzzy sets, determining the optimum type-1 membership function reduces its significance.
\n\t\t\t\tIn order to extract crisp output, the type of the set is first reduced with a type reduction process, which is an extension of defuzzification method. Then type reduced set is defuzzified to obtain a zero order (crisp) output. The foundations of type-2 fuzzy logic system are explained in (Mendel, 2001) in more detail.
\n\t\t\t\tThe type-2 fuzzy set parameters associated with each variable in each rule are identified mostly using supervised learning methods. In (Uncu et.al., 2004) the FCM (Bezdek, 1984) clustering is used to identify the hidden structures. They use uncertainty in selection of level of fuzziness parameter, m, of FCM as the source of uncertainty of the values of inference parameters and identify embedded type-1 FIS for each m to represent discrete interval type-2 FIS (DIT2FIS). Let mr be the rth level of fuzziness, mr∈{m1.. mNM}, where NM is the number of disjoint m values. Thus, they find rth embedded type-1 fuzzy rule for each different mr. μA\n\t\t\t\t\tr represents the membership values associated with rth embedded type-1 fuzzy set A. Their Tagaki-Sugeno FIS is as follows:
\n\t\t\t\tIn (13) r=1…NM, and ai\n\t\t\t\t\tr xT +bi\n\t\t\t\t\tr are regression coefficients associated with ith rule of rth embedded type-1 fuzzy rule. Thus, the problem of building type-2 FIS in DIT2FIS is reduced to finding traditional embedded type-1 FISs.
\n\t\t\t\tType-2 FIS based on Fuzzy functions (Celikyilmaz & Turksen, 2009c;2008a) is a different approach to uncertainty modeling which extends inference strategy of (Uncu et.al., 2004) by introducing two separate uncertainty parameters, the level of fuzziness and the fuzzy function structures to form interval type-2 fuzzy sets. In the next we will briefly present type-2 fuzzy functions methods.
\n\t\t\tThe interval Valued Type-2 Fuzzy Functions, IVT2FF in short, evidently differs from the other type-2 FIS of the previous sections in many ways. For instance, instead of the traditional FIS such as Tagaki-Sugeno structures, the algorithm is based on the Fuzzy Functions structures (Turksen, 2008), which do not require fuzzy connectives (aggregation, implication, defuzzification) and introduce a new fuzzy clustering algorithm. In addition, the uncertainty interval of membership values are identified based on two different sources of imprecision: (i) selection of the level of fuzziness parameter, m, of IFC by identifying an m-bound (ii) determination of the list of optimum structures of fuzzy functions by identifying optimum forms of membership values.
\n\t\t\t\t\tIVT2FF is an iterative hybrid system, in which, the structure is learnt and parameters are tuned by a genetic learning algorithm, to determine the hidden structures viz. information points, which is the fundamental concept of the system identification. The ET2FF has three fundamental phases:
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
The rest of the nm different alleles represent the membership value transformations to be used to shape fuzzy functions. Among many different types, in our models we used power sets, exponential, sigmoid, logistic transformations, etc., of membership values as additional inputs. Each chromosome represents parameters of two separate models of type-1 FIS with Fuzzy Functions using two different m values, each of which has the same fuzzy function structure and regression parameters. Each individual in the population have different parameters and m boundaries so that population is diverse.
\n\t\t\t\t\tThe optimum number of cluster, c* is fixed based on cviFF validity index of Fuzzy Function systems before GLP is processed. At the start of the GLP a wide range is assigned for the boundary values of m-interval, e.g.. {m-lower=1.2, m-upper=7}. For each chromosome, two separate type-1 FIS are constructed using each m-bound and parameters of the rest of the alleles.
\n\t\t\t\t\tIn Fig. 3, FOU of the membership functions and fuzzy functions before and after GLP is shown. Note that these membership functions are the idealized representations of the membership values obtained from the IFC method. We do not curve fit the membership values into membership function in the actual calculations.
\n\t\t\t\t\tOptimization using Genetic Learning Process. FOU of (a) idealized representation of the membership functions (MF), (b) output from principle fuzzy functions, UMF=Upper MF, LMF=Lower MF.
The membership functions, the top graphs, are predicted via IFC method. They are mainly based on two parameters, the level of fuzziness (m) and the structure of the interim fuzzy functions, gi(τi), (as seen in (5) and (6)). The lower and upper membership functions-LMF(Ã) and UMF(Ã)- of the graph in Fig. 3.a on the left is formed using the initial m-lower and m-upper and the initial interim fuzzy function structures for the IFC method.
\n\t\t\t\t\tThe interim fuzzy function parameters are randomly determined by the fuzzy function type and structure alleles (control genes) of each chromosome. They represent different forms of the membership values to be used to identify the interim fuzzy functions. In between the upper and lower boundaries of the shaded area- FOU any other type-1 membership value distribution can be formed using any value from [m-lower, m-upper] interval or any fuzzy function structure by combining different membership value transformations (Fig. 4). After IFC, two type-1 FIS are constructed using membership values and original input variables to build fuzzy functions to represent each local model.
\n\t\t\t\t\tDecision surfaces - f(x,eμ) obtained from GLP using parameters, SVM-Gaussian Kernel allele=0 {Non-linear} and (mlow,mup,Creg,ε)={1.75,2.00,54.5,0.115}, c*=3. uclusi represents membership values of corresponding cluster i.
The algorithm starts with a larger interval of parameter values and optimizes the interval based on the fitness of each chromosome obtained from the combination of the boundary type-1 FISs. The fitness is evaluated as follows:
\n\t\t\t\t\t\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
Each embedded type-1 FIS defines a list of fuzzy functions for each cluster. These functions may or may not have the same input variables because each function of each cluster may be formed with a different membership value transformation used as additional inputs that best describes the local structure. Each fuzzy function would have a different membership value as a variable and its different possible transformations to approximate the fuzzy functions. The algorithm presented here captures the best model parameters in cluster level among the embedded fuzzy models, one for each training vector, and keeps them in a matrix (collection table) to be used for reasoning.
\n\t\t\t\t\tUsing the optimum parameters, from the previoys step the following steps are processed:
\n\t\t\t\t\t\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
For each cluster, only one of these approximated functions can explain the output better than rest of embedded functions. For instance, Fig. 5 depicts prediction performance of four different types of linear fuzzy functions of a single cluster using different m values based on root mean square error (RMSE). These four functions are formulized using different forms of membership value transformations shown in the label of in Fig.5. Every point corresponds to one function of a specific cluster. One specific model with a specific m value can reduce the error better than others. In another cluster, these results might be different and different fuzzy functions for different fuzziness levels could be more preferable. We need to determine the best functions obtained from different sets of parameters. This corresponds to finding the best embedded type-1 FIS model for each training vector using type-2 FIS system.
\n\t\t\t\t\tThe uncertainty in choosing the m values as a function of the error measure of the proposed type-2 FIS (ET2FF) - RMSE values as a function of degree of fuzziness (m) for four different fuzzy function structures. u: improved membership values.
\n\t\t\t\t\t\t
Interval type-2 fuzzy sets (IT2FS) are simplified forms of full type-2 fuzzy sets (FT2FS), where the secondary MEMBERSHIP FUNCTIONs are unified, e.g., equal to 1. Interval IT2FS identify footprint-of-uncertainty (FOU) as depicted in Fig. 6.
\n\t\t\t\t\tMembership functions where base-end-points have uncertainty intervals. The insert represents secondary MEMBERSHIP FUNCTION of x′.
FOU of a FT2FS \n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
In different studies, e.g., (Celikyilmaz & Turksen, 2008e;f), uncertainties of parameters from imperfect information are investigated using fuzzy clustering algorithm. In particular, the FOU of the IT2FS are formed based on the level of fuzziness parameter of FCM clustering.
\n\t\t\t\t\tIn fuzzy clustering methods, fuzziness is measured by the level of fuzziness parameter, m, which determines the degree of overlap between the clusters, viz. structures, granules, etc., identified in the given dataset. In many research, identification of the footprint_of_uncertainty of membership functions of FCM clustering algorithm, e.g., (Hwang & Rhee, 2007; Celikyilmaz & Turksen, 2008e), or hybrid clustering algorithms (Celikyilmaz & Turksen, 2008f) is based on the level of fuzziness parameter. One can investigate the level of fuzziness, m, of particularly fuzzy c-regression model (FCRM) clustering methods (Hathaway & Bezdek, 1993), instead of conventional clustering algorithms. In building fuzzy inference systems, separate functions are identified for each local input-output relation, which are defined with hyperplanes. Therefore, a better way is to construct hyperplane-shaped clusters.
\n\t\t\t\t\tThus, we presented a new type-2 fuzzy inference method (Celikyilmaz & Turksen, 2008g), which can identify the optimum secondary membershp function grades, i.e., weights, of the primary MF grades using genetic algorithms. New data vectors adopt the secondary membership function grades obtained from the training samples in their neighborhood. During genetic learning process, each individual in the population encodes these weights for each training vector for each cluster, separately. This is quite cumbersome process when the number of training vectors are large therefore it is simplified in this paper by implementing transductive learning method. Instead of learning the secondary MF grades of the entire training dataset, for each new data point a new set of weights are learnt from fairly less training vectors, which are close to this new vector in distance. Experimental analysis demonstrates the performance of the new approach.
\n\t\t\t\t\tThe distibution of secondary membership functions is demonstrated in Fig. 7 using an artificial dataset. The dataset ontains single input and single output with two local structures; therefore, the number of clusters is set to two. The primary MF grades, u(x) values, are obtained from FCRM model using list of levels of fuzziness parameter m={1.1,1.25,..,2.6} as shown in Fig. 7 top-right graph, also the base of the 3D graph, the bottom graph in Fig. 7. The bottom 3-D graph in Fig. 7 displays secondary membership function of a single point xk=0.5. The secondary membership function values of nearest data points are optimized with genetic algorithms.
\n\t\t\t\t\tTop-left) Artificial Dataset, (Top-right) FOU by m∈[1.1, 2.6], (Bottom) secondary MF of data point x′=0.5.
In this paper we present various different fuzzy function approaches which is a summary of our research for the last five years. Our experiments have shown that as we introduce the uncertainty, we gain more performance from the models that we build to represent the real systems, i.e., variaous natual language processing applications on infomration retrieval and information extraction. Hence, the interval type-2 fuzzy system models based on fuzzy functions have shown better performance improvement compared to the type-2 fuzzy function models (Celikyilmaz & Turksen, 2008a). Later on we have developed the full type-2 fuzzy functions method with which we can introduce second-order uncertainties to the system model. The results have shown that the full type-2 fuzzy functions can improve the perforamnce of fuzzy system models when there is uncertainty. Since natural language appliations are imprecise in nature, we prefer to use full type-2 fuzzy functions when building language models. In addition the space limitations keep us presenting all the result from different our different system modeling approaches. Hence, in the next we will present the result of our experiments using Full Type-2 Fuzzy Functions, in other words, Type-2 Fuzzy Inference System (T2FIS) presented in this paper. We will build a Question and Answering (QA) system.
\n\t\t\tThe aim of QA systems is to find precise answers to natural language questions from large document collections by processing several modules in sequence including question analysis, document retrieval, answer extraction and answer selection. In this paper we are particularly interested in answer selection part, in which retrieved candidate answers are ranked based on a textual entailment model Textual entailment models are first introduced in Pascal RTE conference (Dagan et.al. 2006).
Inasmuch our QA system is designed to return candidate sentences from a corpus, instead of returning exact answer phrases, such as we return the sentence containing the answer-phrase but not extract the phrase Answer-extraction is left out as a future research study on natural language processing applications.
t: Harry was born in Iowa.
\n\t\t\t\th: Harry’s birthplace is Iowa.
\n\t\t\tt entails h, otherwise we recognize the relation between the meaning of the texts as false entailment. In this section, we demonstrate experiments conducted on Textual Entailment datasets (freely available from PASCAL recognizing textual entailment (RTE) challenge conference- http://pascallin.ecs.soton.ac.uk/Challenges/RTE/) using the proposed T2FIS method. The goal of RTE challenge is to recognize semantic inference that a textual entailment defines directional relation between two text fragments, called text (T) and hypothesis (H) so that a human being can infer that H is most likely true on the basis of the contents of T. As a further note, we use the entailment model to build a QA system.
\n\t\t\tUsing the RTE datasets, we build a classifier model using proposed T2FIS method. This model is build to be implemented to our Question Answering (QA) system to rank the sentences retrieved from a search engine while matching each retrieved sentence (T) with the question query sentence (H). The question query is transformed into a sentence putting a placeholder to where the answer should be in the question sentence.
\n\t\t\t\n\t\t\t\t
Example Pairs | \n\t\t\t\t\t\tEntailment | \n\t\t\t\t\t
T: In February 2002, President George Bush visited China to mark the 30th anniversary of Nixon\'s historic trip. H: Nixon visited China in February 2002. | \n\t\t\t\t\t\tFALSE | \n\t\t\t\t\t
T: The Chernobyl nuclear-power plant is in Ukraine, but the reactor that exploded during the night of April 26, 1986, is only 10 miles from the Belarusian border H: The Chernobyl disaster took place on the 26th of April, 1986. | \n\t\t\t\t\t\tTRUE | \n\t\t\t\t\t
T: Microsoft was established in Italy in 1985. H: Microsoft was established in 1985. | \n\t\t\t\t\t\tFALSE | \n\t\t\t\t\t
Examples of Text-Hypothesis pairs from Recognizing Text Entailment Challenge.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
Since the task is text entailment, we extracted two verb match statistics using WordNet’s cause to and entailment relations. For each verb pair that groups a verb from the text vT and one from the hypothesis vH we tested either a caused by or entailment relation when;
\n\t\t\t\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
To generate separate features for each relation, we counted the number of verb pairs constructed in the above form.
\n\t\t\tWe generate the train and testing datasets using the T-H pairs from RTE challenge and extract features as explained above to form the inputs. The binary output variable having the value ‘1’ indicates “true entailment” and ‘0’ “false entailment”, and these are assigned manually (given by the RTE challenge datasets). We extract 29 features using different combinations of the lexico-syntactic and semantic features. We use 1670 T-H pairs for building the learning models--training and 2400 pairs for testing purposes. False and true entailments are evenly distributed. We used 10, 50, 100, 200 number of training vectors as the number of nearest neighbors to build four different T2FIS models, i.e., T2FIS_10, T2FIS_50, T2FIS_100, T2FIS_200, and analyzed the difference in the experiments. For the rest of the benchmark models, we randomly selected 750 training samples five times to build different models and analyzed their average testing performance on the same testing dataset and measured their error margins between five experiments, i.e., standard deviation of the accuracies.
\n\t\t\t\n\t\t\t\t
Since the classification model outputs are probabilities, different threshold values (to discern between two classes) values are varied to obtain the optimum True Positives (TPs) and True Negatives (TNs) during learning stage of each modeling approach. The threshold values that are identified by the structure identification are used during inference to estimate class labels of testing dataset. The same parameters that are used in the previous experiments is used in this experiments as well with the exception that the algorithms are designed to find classifier functions, e.g., SVM for classification, and FCCM of T2FIS methods are used. The feature extraction, explained above, is implemented as a part of entailment into our QA system using Java and the T2FIS is implemented using Matlab. The average accuracy results from the five repetitions of experiments and the model with the best average accuracy are shown in Table 2.
\n\t\t\tModel --accuracy | \n\t\t\t\t\t\tTesting Dataset Average Accuracy | \n\t\t\t\t\t\tsignificance-test between the best T2FIS model and the benchmarks (p<0.05) | \n\t\t\t\t\t
T2FIS-10 | \n\t\t\t\t\t\t0.579 | \n\t\t\t\t\t\t\n\t\t\t\t\t |
T2FIS-50 | \n\t\t\t\t\t\t0.585 | \n\t\t\t\t\t\t\n\t\t\t\t\t |
T2FIS-100 | \n\t\t\t\t\t\t0.598 | \n\t\t\t\t\t\t\n\t\t\t\t\t |
T2FIS-200 | \n\t\t\t\t\t\t0.582 | \n\t\t\t\t\t\t\n\t\t\t\t\t |
ANFIS | \n\t\t\t\t\t\t0.547 | \n\t\t\t\t\t\t0.001 | \n\t\t\t\t\t
SVM-LIN | \n\t\t\t\t\t\t0.568 | \n\t\t\t\t\t\t0.021 | \n\t\t\t\t\t
SVM-RBF | \n\t\t\t\t\t\t0.561 | \n\t\t\t\t\t\t0.009 | \n\t\t\t\t\t
NN | \n\t\t\t\t\t\t0.550 | \n\t\t\t\t\t\t0.006 | \n\t\t\t\t\t
Accuracy results of the Text Entailment for QA tasks.
Based on the results of this experiment, the best testing accuracy is obtained when the T2FIS is executed for when 100 nearest training vectors are used (T2FIS_100). Compared to the benchmark methods, there is a [5-9%] improvement when the proposed T2FIS_100 is used. Fig. 8 shows accuracies along with their standard deviations across five separate experiments.
\n\t\t\tAccuracy Comparison Graph between the models constructed based on five repetitions. The standard errors are also shown as error-bars.
We also measure the statistical significance of the proposed approach T2FIS on classification problems. The same two-sample left-tailed t-test with 95 percent confidence level is used to indicate the significance of the optimum models of each methodology. Our hypothesis is that cross validation errors of the best proposed method (T2FIS_100) and the rest of the models are same with 95% confidence. In Table 2 significance probabilities are shown. In all experiments the T2FIS_100 model is significantly better than the benchmark models (p<0.05). Thus, we can conclude that the proposed algorithm has comparable/significantly better results than other powerful well-known modeling tools.
\n\t\t\tThe proposed approach helps us to quantify the uncertainty in the membership functions used in the fuzzy system models and variation in model parameters. It is shown that it is possible to capture the variations with a list of discrete membership functions and weighing them individually to incorporate their individual effects to the model. We quantify this uncertainty based on the imprecision in the level of fuzziness parameter of the fuzzy clusters we identify. The real problems can be modeled by using type-2 membership functions which can be derived from the changing values of the fuzziness of the clusters. Hence, when the expert is not present to identify the fuzzy sets, this method could provide better solutions. With the two experiments, we showed that the T2FIS is better compared to the rest of the fuzzy or non-fuzzy reasoning approaches based on the modeling error.
\n\t\tFuzzy logic encompasses conceptual framework of sets and logic that is able to handle both precise and imprecise information and meaning. Although fuzzy systems still do not necessarily outperform human in dealing with uncertainty and imprecision, it helps to reduce the real world problems to a scale that is possible for computing solutions that was impossible before. The principal objective of the presented methods of this paper is to develop applications to enable information extraction under uncertainty, particularly on the conception and design of autonomous systems for natural language processing applications specifically on question and answering systems and textual entailment mechanism. A direct practical application of fuzzy logic to these fields does not seem to exist at present. Thus, higher order fuzzy system models based on fuzzy functions will have many uses in textual and semantic analysis, data mining, and search algorithms in the near future.
\n\t\t\tIn this paper, a new approach to information extraction via fuzzy functions is presented. The presented type-2 fuzzy inference system is used for uncertainty quantification of real-world data. Partitioning a given set of data into granules is most fundamental problem in pattern recognition and data mining. With the presented fuzzy inference system, we define membership functions based on the given dataset and use fuzzy clustering methods. The approach of membership function elicitation of type-2 fuzzy inference system is a category of hybrid knowledge-data class of fuzzy set elicitation and enables employment of different membership functions and local dependency function structures for each cluster. The major benefit of this approach is that, it does not require definition of membership function by an expert. The primary membership functions are found from fuzzy clustering methods presented in the paper and the secondary membership grades are optimized with genetic algorithms. The algorithm adopts simple type-reduction and does not require defuzzification. Textual entailment task is a challenging problem and depends on careful analysis of the features between the question and candidate answer pairs and an efficient classifier model such as uncertainty modeling tool presented in this paper.
\n\t\tLocal anesthetic agents have been used in clinical dentistry to allay or eliminate pain associated with invasive operations as early as the nineteenth century [1]. Local anesthetics are used routinely also in oral and maxillofacial surgery. Despite that local anesthetics are reliable and efficient drugs, the risks that practitioners need to be aware of were also reported [2].
Complications associated with local anesthetics can be evaluated systemically and locally. Common systemic reactions due to local anesthesia are reported as psychogenic reactions, systemic toxicity, allergy, and methemoglobinemia. Common local complications associated with local anesthesia are reported as pain at injection, needle fracture, prolongation of anesthesia and various sensory disorders, lack of effect, trismus, infection, edema, hematoma, gingival lesions, soft tissue injury, and ophthalmologic complications [2, 3].
This chapter is presenting the local and systemic complications associated with the local anesthetics used in oral and maxillofacial surgery. The prevention of complications and management methods are also emphasized.
Local anesthetics can be classified according to their chemical structure, a rate of onset, potency, and duration of action. Chemically, they are either amino esters or amino amides (i.e., an aromatic, lipophilic ring connected to a hydrophilic amine group by an intermediate chain containing either an ester or amide linkage). Ester local anesthetics are hydrolyzed in the plasma by pseudocholinesterase into para-aminobenzoic acid (PABA) and other derivatives, whereas amide-type local anesthetics are metabolized by the liver. The rate of hydrolysis has an effect on the potential toxicity of a local anesthetic. Allergic reactions that occur in response to ester local anesthetics usually are related to para-aminobenzoic acid, which is a major metabolic product of many ester local anesthetics. The rates of biotransformation of amide group lidocaine, mepivacaine, etidocaine, and bupivacaine are similar. Articaine, which contains both amide and ester, metabolizes both in the liver and blood. The ester group (cenzoic acid esters) includes cocaine, procaine, chloroprocaine, tetracaine, and benzocaine. The amide group includes lidocaine, mepivacaine (Carbocaine), prilocaine (Citanest), bupivacaine (Marcaine), etidocaine (curanest), dibucaine (nupercaine), and ropivacaine (Naropin).
Ester local anesthetics are not available in dental cartridges essentially because of several reasons such as the lack of efficacy, the potential for allergenicity, and the advantages of amino amides [4, 5, 6, 7].
This psychogenic answer is associated with either the patient’s body counterbalance to an anxiety-inducing situation or due to adrenaline secreted by the vasoconstrictor agent. As a result of mood changes, heart rate, respiratory rate, and blood pressure are altered. Patients often have a blush or erythema which mimics allergic reactions, hyperventilation, nausea, and vomiting [3]. It is important to understand the patient and make them relax. In more severe cases, these reactions should be maintained as syncope and hyperventilation. For preventing psychogenic reactions, the patient should be relaxed before administering local anesthetic injections. Using oral sedatives is an efficacious method to manage dental fears. Initial dosage should be dependent on patient health, age, weight, and duration of the operation. For healthy adult patients in short-term operations antihistamine-diphenhydramine (Benadryl) 50 mg 1 hour prior to the operation, moderate length (1–2 hours) operation benzodiazepine, triazolam (Halcion) 0.125–0.5 mg 1 hour before the operation triazolam, for longer duration (2–4 hours) benzodiazepine such as lorazepam (Ativan) 1–4 mg may be given 1–2 hours prior to the operation or 30–60 minutes prior for the sublingual preparation may be described and given. Pharmacologically, mildly and moderately anxious dental patients can be managed using sedation or extremely anxious or phobic patients using general anesthesia [8, 9].
Local anesthetic systemic toxicity develops when a sufficient (toxic) concentration of anesthetic drug in the blood level reaches to the central nervous system and cardiovascular systems.
Initial symptoms are characterized by central nervous system signs such as excitation, convulsions, followed by loss of consciousness and respiratory arrest. These symptoms are often accompanied by cardiovascular signs such as hypertension, tachycardia, and premature ventricular contractions. The clinical signs and symptoms usually show objective symptoms such as quick talking, flicker, and tremor in the extremities [10, 11].
Predisposing factors are associated with age, weight, other drugs, gender, the presence of disease, genetics, vasoactivity, concentration, dose, route of administration, the rate of injection, vascularity of the injection site, and the presence of vasoconstrictors [7].
In order to prevent systemic toxicity, the patient should be evaluated. The volume of local anesthesia should be decreased, young or lightweight patients should not be treated all four quadrants at one visit using local anesthetic alone; accurate and slow injection technique, adjustment of dosage divided administration and aspirating technique, using agents with low toxicity such as ropivacaine and levobupivacaine, and performing an aspiration test are recommended [11]. Preventing from a toxic dose complication, it should be evoked that for healthy adults, the suggested maximum safe dose of 2% lignocaine in 1:80,000 adrenaline is four-and-a-half 2 or 2.2 mL cartridges (180–198 mg lignocaine); for 3% prilocaine and felypressin 0.03 i.u./mL, the maximum safe dose is 400 mg (six 2 mL cartridges) [12]. Another strategy to reduce toxicity is using the guideline of 1/10th cartridge per kilo as a rough guide to the maximum dose [13].
Dentists should be aware that excessive doses of topical anesthetics while these agents are more concentrated to facilitate infiltration may lead to toxic effects, particularly in children.
Treatment at the office includes airway support, administration of 100% oxygen, supine positioning, and protection from injury in the event of seizure activity, treating convulsions (benzodiazepines or thiopental; propofol cannot be used in patients with unstable blood pressure, heartbeat) [14]. If severe hypotension arrhythmia occurs, administration of the infusion of a 1.5 mL/kg 20% lipid emulsion over approximately 1 minute and then starting with continuous application at 0.25 mL/kg/min = 1000 mL/h. Studies have reported a resuscitation effect at a total dose of ≤10 mL/kg; therefore, 12 mL/kg can be used as an approximate estimate for the maximum dose. The adrenaline dose should be based on resuscitation guidelines such as those of the American Heart Association. The American Society of Regional Anesthesia and Pain Medicine standard of <1 μg/kg does not need to be strictly adhered to [11].
Allergy is also known as hypersensitive reactions, initiated by immunological mechanisms acquired through exposure to a specific allergen; re-exposure to which produces a heightened capacity to react. The prevalence of allergic reactions to amide group local anesthetics is rare. It is predicted that less than 1% of all complications are caused by an allergy. Many of the complications doubt to be allergic are actually anxiety-induced reactions [15].
Ester-type local anesthetics are more allergenic than amide-type local anesthetics. Therefore, amide-type anesthetics are broadly used, among which lidocaine is the most commonly used for dental anesthesia epinephrine involving form. Adverse reactions to local anesthesia are caused by preservatives (e.g., methyl-p-hydroxybenzoate), antioxidants (e.g., bisulfate), antiseptics (e.g., chlorhexidine), vasoconstrictor (e.g., sulfites), and other antigens such as latex, as well as local anesthetic drugs themselves [5].
Allergic reactions may include mild symptoms, such as urticaria, erythema, and intense itching, as well as severe reactions in the form of angioedema and/or respiratory distress. Even more severe life-threatening anaphylactic responses include symptoms of apnea, hypotension, and loss of consciousness [15].
In order to diagnose allergies, the skin prick test is the most endorsed. When skin prick test results are determined to be negative, intradermal testing should be performed for patients who have a history of allergy to local anesthetics intradermal tests become obligatory [15, 16].
The following treatments a local anesthetic patient had tested negative in the allergy tests, should be used.
The initial treatment for an allergic reaction in office at the first step should be the removal of the causative agent. For the management of mild symptoms, oral or intramuscular antihistamine-diphenhydramine (Benadryl), 25 or 50 mg, should be given. Additionally, hydrocortisone cream may be prescribed to relieve skin itching or erythema. In life-threatening cases basic life support, intramuscular or subcutaneous epinephrine 0.3–0.5 mg, and hospitalization services should be given.
Anaphylaxis is an acute potentially life-threatening hypersensitivity reaction. The clinical symptoms of anaphylaxis are depending on the organ systems involved. Uncontrolled co-existing asthma, mast cell disorders, and patients with specific allergens such as peanut and tree nut allergy are the risk factors for anaphylaxis. In emergency management of anaphylaxis in the office, due to guidelines of the Australasian Society of Clinical Immunology and Allergy should be in these steps, the patient should lie flat, but also in the case of breathing difficulty, the patient is allowed to sit. Adrenaline 1:1000 dilution (0.01 mg/kg up to 0.5 mg per dose) should be administered intramuscular with 1-mL syringes, 21 gauge needles, and should be repeated every 5 minutes as needed. Another recommendation for epinephrine is or children and adults who weigh 30 kg or over is 0.3 mg. For those weighing 15 to 30 kg, the epinephrine dose is 0.15 mg. The use of adrenaline auto-injector can also be chosen, which is carried mostly by heavy allergic patients themselves.
Adrenaline should be administered for anaphylaxis by intravenous (IV) route only in the case of profoundly hypotensive patients or patients who develop a cardiopulmonary arrest or those who fail to respond to multiple doses of IM adrenaline because of the potential cardiovascular adverse effects of IV administration of adrenaline [17, 18].
Estelle and Simons evaluated evidence-based pharmacologic treatment of anaphylaxis. They agreed using epinephrine at the first step intramuscular in the treatment of anaphylaxis. But the use of antihistamines and glucocorticoids is controversial. Some authors claim using antihistamines is not effective because they are not effective on upper or lower airway obstruction, hypotension, or shock, while others advocate that these drugs decrease the side effects urticaria, flushing, headache, hypotension, and rhinorrhea. In the World Allergy Organization survey, glucocorticoids were reported to be the second most widely available medications (after epinephrine) for anaphylaxis treatment globally, even though some claim glucocorticoids have no proven benefit in anaphylaxis [19].
As a result first step of treatment must be epinephrine additionally glucocorticoids and antihistamines may use to treat severe systemic reactions.
Methemoglobinemia is a unique dose-dependent reaction where the iron in hemoglobin is stabilized in the ferric (Fe3+) form, unable to attach oxygen, leading to tissue hypoxia and causing a varying degree of cyanosis. Methemoglobinemia can be either inherited or acquired [20].
The risk of methemoglobinemia increased in infants and the elderly. Patients with underlying health problems; liver cirrhosis, with underdeveloped hepatic and renal function; heart disease; and pulmonary disease (chronic obstructive pulmonary disease, pneumonia) are under the risk of methemoglobinemia. When administered in excessive doses, the local anesthetics mostly prilocaine and benzocaine (90% of reported cases) and barely lidocaine and articaine may also lead to methemoglobinemia [21].
Symptoms of cyanosis will be observed in nail beds and mucous membranes. In more severe cases, headache, dizziness, fatigue, dyspnea, and tachycardia are seen. For diagnosis in the dental clinic, pulse oximetry and in-hospital arterial blood analysis play an essential role [21].
Management of methemoglobinemia begins with supplemental oxygen (100%) immediately. As a guideline, methylene blue, which is a heterocyclic aromatic chemical compound increasing the rate of conversion of methemoglobin to hemoglobin, may be given to a symptomatic patient. For severe cases, hyperbaric oxygenation may also be used if available. Methylene blue should be administrated in 1 to 2 mg/kg doses, given as 0.1 mL/kg of a 1% solution (10 mg/mL) intravenously over 5–10 minutes every hour up to a 7 mg/kg maximum. Repeated doses may be necessary within 30–60 minutes of the initial dose [22, 23]. Guay summarizes 242 cases of methemoglobinemia complications related to dental local anesthetics lidocaine, bupivacaine, cocaine, mepivacaine, prilocaine, and tetracaine in children and adults. He concluded that benzocaine should be out of usage. In a specific patient group, in children younger than 6 months, in pregnant women, or in patients taking other oxidizing drugs, prilocaine should not be used. The dose should be limited to 2.5 mg/kg [21].
Pain on injection can be due to specific circumstances such a temperate of the solution, velocity of injection, dull needles, needles with barbs, or aggressive insertion of the needle, damaging soft tissues, blood vessels, nerves, or the periosteum and causing more pain and other complications.
The burning is dependent on the rate of injection and the acidity of the solution. Lidocaine causes an intense burning sensation when injected locally. When the needle penetrates a nerve, the patient may also feel a sudden “electric” shock, suddenly moving the head, with the risk of self-inflicted damage [24].
In order to prevent discomfort, topical anesthetic application, warming anesthetics to body temperature, using a smaller-gauge needle (27 gauge), switching to a fresh needle when you have to inject multiple times in the same lesion or when you have multiple injection sites, and injecting slowly and with low pressure which reduces pain are done. A rate of 30 seconds per mL of solution is recommended. An inadequate injection site can lead to an intramuscular or intraneural injection blunting of the needle, side of injection anatomic structure (palate) it is unacceptable to feel a little pain during injection [13, 24, 25].
Needle breakage in the oral cavity after local anesthesia is a rare complication, since the establishment of non-reusable, stainless steel dental local anesthetic needles. In most cases, needle fracture happened with 30-gauge needles and during inferior alveolar nerve block, as a result of either incorrect injection technique, improper choice of hypodermic needle magnitude, or unexpected motion of the patient or assistants [26].
In order to prevent needle fracture, first the injection needles should be checked; 30-gauge and short needles should not be used for inferior alveolar nerve block in adults or children (25–27 should be chosen). Needles should not bend while inserting them into soft tissue [26, 27].
In the case of a broken needle, if visible, it should be removed immediately with a hemostat. If this is inaccessible, computed tomographic (CT) scanning should be taken to ensure the location of the needle, and under general anesthesia, the patient should be operated. In the literature for the removal of the fragment, mostly superficial mucosal incision perpendicular to the trajectory of the needle followed by blunt supra-periosteal dissection to spare vital structures is recommended [28, 29].
Acham et al. in 2018 made an analysis of the literature complication of needle fracture following dental local anesthesia on 36 reports and 59 needle breakage events; they concluded that three-dimensional imaging techniques should be taken to see the broken fragment and also surrounding structures like vessels and the the parotid gland. It is important because 27 out of 57 cannula fragments were located in the pterygomandibular space, and the choice of the removal of the fragment, whether general or local anesthesia, should be dependent on the patient’s systemic condition [30].
Prolonged anesthesia, paresthesia, or neuralgia may occur following dental local anesthetic blocks. This may be temporary, where after a few days, weeks, or months, sensation returns or it may be permanent [31]. This mostly involves nervus lingualis or nervus mandibularis or both [32]. The nerve may be damaged during injection by direct injury, or the needle may damage the intraneural blood supply, resulting in a hematoma, or the needle may traumatize the medial pterygoid muscle which results in trismus. Neurotoxicity of the local anesthetic is another theory for nerve damage [33]. Procaine and tetracaine cause more damage than bupivacaine or lidocaine [34]. Paresthesia or neuralgia complication is mostly transient but may also be permanent if the anesthetic solution is injected directly into the nerve. Due to a numb feeling, the patient may have discomfort such as tongue biting, drooling, loss of taste, and speech impediment. Sullivan et al. conducted a randomized, double-blind, placebo-controlled trial on 496 patients with Bell’s palsy. They maintain treatment with steroids within 3 days after onset quite advances the chance for full recovery at 3 or 9 months [35]. Piccinni et al. conducted an analysis of reports to the FDA Adverse Event Reporting System; about 573 cases of paresthesia and dysesthesia after local anesthetics between 2004 and 2011 were performed. They concluded that the use of prilocaine, articaine, or both drugs has a higher risk of paresthesia [36].
If a nerve is damaged due to dental local anesthesia, the first treatment should be managing the pain. In order to decrease local anesthesia-dependent nerve injury, avoiding high concentration of anesthetic agent for inferior alveolar nerve blocks (use 2% lidocaine as standard), preventing iterative injections, and avoiding inferior alveolar nerve blocks are done by using high concentration agents (articaine) infiltrations only. The use of a low daily dose of multivitamin B, to regaining nerve healing and function, has been recommended [37, 38].
Reasons for unsuccess in obtaining local anesthesia can be dependent on anatomical variants, pathological and psychological factors, choice of technique and solution, and poor technique [24].
Anatomical factors comprise accessory nerve supply, alteration in foramen location, atypical development of the nerves (bifid mandibular canals), and bone density [39, 40].
Pathological reasons for the failure of anesthesia are trismus, infection, inflammation, and previous surgery or trauma. Inflammatory diseases altering the pharmacokinetics and pharmacodynamics of local anesthetics cause a response to decrease and unfavorable effects to increase [41].
Local anesthetic failure or difficulty to obtain satisfactory analgesia commonly occurs in the situations with inflammations such as pulpitis and apical periodontitis acute periodontal abscess or pericoronitis [42]. Psychological determinants such as angst and anxiety can also cause local anesthesia failure [39].
Poor technique failure mostly occurs to obtain mandibular anesthesia. If the needle is inserted and advanced too deeply and too far dorsally, the terminal branches of the facial nerve within the deep lobe of the parotid gland are affected. Direct anesthesia to the facial nerve can force a rapid onset that occurs while the anesthetic agent is being injected; reflex vasospasms of the external carotid artery can lead to ischemia of the facial nerve, so facial nerve palsy occurs. The patient is unable to wrinkle the forehead, raise the eyebrow, close the upper eyelid, retract the commissure of the lips to smile, and turn down the lower lip on the affected side. The removal of contact lenses and closing of the eye on the affected side in Bell’s palsy prevent corneal abrasion or drying [43, 44].
In most cases, paralysis occurs immediately after mandibular anesthesia injection, but there are also some cases in which paralysis starts lately. Cakarer et al. have a case report for late paralyses. They extracted simple teeth, without any complication, and 1 day after the patient returned with complaints of a weakness of the muscles of the left side of his face. On the examination, they observed Bell’s palsy sign on the left side and unilateral expressionless, and there was no pathologic sign in the wound or any herpetic lesions. They consulted the patient with the Department of Ophthalmology and the Department of Physical Therapy and Rehabilitation. For the treatment lubricant eye drop (4 × 1), tobramycin ophthalmic solution (4 × 1) and lanolin eye ointment (during night) supported by eye patch were used. For 4 weeks, galvanic stimulation of the affected side of the facial nerve was performed, and mime therapy was recommended. In 2 weeks all of the symptoms disappeared [45].
If the needle is inserted too high and deep, N. auriculotemporalis will be affected, and the feeling of “numbness” will occur. There has been a report of sudden unilateral deafness following inferior dental nerve anesthesia.
Trismus is defined as a painful circumstance with inability to open the mouth normally. Several factors cause trismus such as multiple injections in a short period of time in the same area, intramuscular injections inside the muscle or trauma to muscles (either the lateral pterygoid muscle or the temporal muscle) which cause hematoma formation and fibrosis, needle fracture in the muscles inserting to styloid process, inaccurate positioning of the needle when giving the inferior nerve block or maxillary posterior injections or inflammation of the masseter and other masticatory muscles, a low-grade infection, and excessive volumes of local anesthetic solution deposited into a bounded region which cause expansion of tissues. In the acute phase, pain from hemorrhage leads to muscle contraction and limitation of motion.
Once trismus develops, some cases will resolve spontaneously. Progression of trismus to chronic hypomobility and fibrous ankylosis may be prevented by the early institution of treatment consisting of heat therapy; soft diet; prescription of analgesics, anti-inflammatory drugs, antibiotics, muscle relaxants; or physiotherapy. Trismus caused by an infection needs to be treated by antibiotics. Usually, trismus will resolve in 6 weeks, with a range of 4 to 20 weeks.
Awareness of the anatomical landmarks and muscles: palpation of bony anterior ramus for temporalis muscle, pterygomandibular fold for pterygoid muscle, and appropriate angulation of the needle and bone contact before injecting are good methods for avoiding trismus via local anesthesia.
Intraorally the Vazirani-Akinosi technique, the closed-mouth mandibular nerve block technique, or extraoral techniques can provide anesthesia to trismus patients [43, 46].
Infection complication is rare since the usage of disposable needles and glass cartridges. Infection may extend to tissues by penetration of the needle through a contaminated tissue, because of the needle being contaminated before an operation or improper preparation of local anesthetic diluted solutions. On the other hand, a latent viral infection may be reactivated due to the trauma of the procedure which may be responsible for neural sheath inflammation.
The area to be penetrated should be cleaned with a topical antiseptic prior to insertion of the needle. Antiseptic mouthwash solutions such as chlorhexidine gluconate should be considered for all regional techniques. The local anesthesia should not be injected through the infected area.
Injecting local anesthesia during the presence of infection is important to increase the pH of anesthetic agent in order to increase efficiency because the infected tissue is more acidic. This process is called anesthetic buffering and leads to patient comfort during injection, fast onset of anesthesia, and lower postinjection tissue injury. Recommendation for treatment of infection is antibiotics (penicillin V 500 mg every 6 hour for 7–10 days), analgesics, heat, drainage, and physiotherapy [2, 31, 47].
Swelling of tissues can be due to trauma during injection, infection, allergy, hemorrhage, and injection of irritating solutions.
The management of edema is dependent on the cause. Allergy-induced edema treatment consists of intramuscular epinephrine injection as mentioned above and, additionally, antihistamine and corticosteroid administration and consultation with an allergist to determine the precise cause of the edema. Trauma-induced edema should be managed as a hematoma. For the treatment of edema produced by infection, antibiotics should be prescribed [27].
Hematoma formation as a complication of local anesthesia is the result of a venous or arterial laceration; intra-arterial blood pressure increase causes effusion of blood into the surrounding soft tissues. While injecting, if there is a high pressure, it may be a warning injecting against the bloodstream. The size of a hematoma depends on the density and compactness of the affected tissue; when a vein rupture is concerned, hematoma does not necessarily occur. Discoloration on the area, a bruise may accompany hematoma [48].
From the anatomical point of view, different nerve effects cause hematoma on specific regions such as anterior superior alveolar (infraorbital) nerve block below the lower eyelid, incisive (mental) nerve block at the chin area, buccal nerve block or any palatal injection within the mouth, and posterior superior alveolar nerve block extraoral in the lower buccal region of the mandible, intraoral distal to maxillary tuberosity.
Hematoma formation can be prevented by aspirating before injecting the anesthetic solution, by using a short needle and a minimum number of needle penetrations into tissues. When swelling forms immediately after injection, localized pressure should be applied with a minimum of 2 minutes. This will stop the hemorrhage.
Both swelling and discoloration usually subside in 10 to 15 days. Ice packs should be held for the first 24 hours after surgery following which intermittent hot moist packs can be used to resolve the condition and massage therapy using a heparin cream. Antibiotics should be prescribed if the hematoma is large in order to prevent the development of a wound infection [14, 49].
Gingival lesions consist of recurrent aphthous stomatitis, and herpes simplex can occur intraorally after a local anesthetic injection or after any trauma to the intraoral tissues. The exact mechanism is unknown, but any trauma to tissues by a needle may activate the latent form of the disease process that was present in the tissues with previous injection.
No management is necessary until there is severe pain. In order to relieve pain, topical anesthetic solutions (e.g., viscous lidocaine) may be used on affected areas. A concoction of identical amounts of diphenhydramine and milk of magnesia rinsed in the mouth effectively covers the ulcerations and provides relief from pain. Triamcinolone acetonide without corticosteroid can remedy pain [14, 27].
Lip or tongue biting or chewing can occur on children with special needs or disabled patients, following dental local anesthesia with the unfamiliar sensation of being numb [50]. Shorter-acting local anesthetics such as plain mepivacaine should be chosen, and the patient or the guardian should be warned about eating, drinking hot fluids, and biting on the lips or tongue to test for anesthesia; cotton rolls can be placed between the teeth and soft tissues to prevent chewing. In order to accelerate recovery time for sensation, an alpha-adrenergic receptor, phentolamine mesylate (OraVerse), may be injected. For adults, the proposed dosage is 1 to 2 cartridges of phentolamine mesylate (a dose of 0.4 to 0.8 mg), while for children the proposed dosage is 0.5 to 1 cartridge (0.2 to 0.4 mg) [50, 51] Malamed [52].
Swelling may decay after 2 to 3 days. The lesion will heal over the next 10 to 14 days. For pain complains, analgesics may be prescribed and topical local anesthetic gel may be applied to the area.
The most common complications include diplopia (dual vision), ophthalmoplegia (paralysis or weakening of eye muscles), ptosis, and mydriasis (dilatation of pupil). In extremely rare instances, amaurosis (partial/total blindness) can be seen. All these complications are transient and disappear on interruption of the anesthetic effects [53].
Intraarterial injection or perforation of the vascular wall would stimulate the sympathetic fibers running alongside the internal maxillary artery until reaching the orbit. The intravenous injection could reach the cavernous sinus via the pterygoid plexus and anesthetize the oculomotor, trochlear, or abducens nerves.
Horner’s syndrome may occur after an inferior dental nerve block anesthesia because of penetration of the local anesthetic through the lateral pharyngeal and prevertebral spaces, causing barrier of the stellate ganglion [54, 55].
Alamanos et al. conducted a systematic review in 2016 on ophthalmologic complications following dental local anesthesia with 66 reports and 89 cases. They found that the Gow-Gates technique for mandibular block anesthesia is only associated with diplopia, vision impairment is more associated with inferior alveolar nerve blocks than with posterior superior alveolar nerve blocks, and the latter technique has rarely been reported as a cause of amaurosis. Ocular complications in the literature are mostly with an injection of lidocaine [56].
In order to minimize the possible complications, visualization of the regional anatomy, numerous aspirations while injection, and aspiration on at least two planes before administration local anesthetic are performed.
Administration of a local anesthetic can be associated with complications of adverse events. In order to prevent local anesthetic complications, the medical history of the patients should routinely be evaluated in details, and effective anxiety management should be performed. Doses of local anesthetics should be always strictly assessed with body weight, and the maximum recommended dosages should be considered. While administrating anesthesia, the painless injection should be performed, avoiding intravascular or intramuscular or direct trauma to the nerve. New developments should be followed by the practitioners to reduce possible complications associated with the local anesthesia.
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The majority of European Member States (MS) has enforced this directive and completed fully or, in some cases, partially, with European smart cities to use and share the same criteria and methodologies and along with transport operators to communicate to the public the relevant results and respective action plans by ensuring the citizen’s awareness about the environmental noise, the quality acoustic environment, and their effect to their professional and everyday lifestyle. Today, 18 years after its first edition, the European Directive 2002/49/EC is needed to be reformulated to take into account all defects that have been identified and to adapt as well as possible to contemporary constraints. New methodology tools have been developed especially regarding soundscaping and environmental acoustic rehabilitation of urban areas, and the respective chapter will describe the progress being made on these smart developments of cities and infrastructures. This chapter will also evoke criticisms of these smart tools and will present results from several—state of the art—case studies especially regarding the practical and theoretical limits they face.",book:{id:"7624",slug:"smart-urban-development",title:"Smart Urban Development",fullTitle:"Smart Urban Development"},signatures:"Konstantinos Vogiatzis and Nicolas Remy",authors:null},{id:"63405",doi:"10.5772/intechopen.80810",title:"Restructuring Gauteng City Region in South Africa: Is a Transportation Solution the Answer?",slug:"restructuring-gauteng-city-region-in-south-africa-is-a-transportation-solution-the-answer-",totalDownloads:1850,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"The Gauteng city region forms the economic hub of socio-economic development and growth in South Africa. The province itself includes the Johannesburg metropolitan city, Ekurhuleni metropolitan city as well as Tshwane municipality—key urban growth regions of Gauteng province, South Africa, and by extension Southern Africa. The region exhibits the rapid urbanisation challenges typical in any developing country city. Rural–urban migration, pressure on infrastructure demand, supply and capacity constraints and mismatches in urban governance structures with respect to service delivery have remained stubborn challenges. Initiatives and strategies to resolve urban traffic congestion such as through road construction and highway expansion (physical instrument), e-tolling of roads (financial instrument), innovative housing and waste management technology deployment (technology instruments) as well as presenting advanced spatial planning and development and management systems (planning and regulatory instruments) have been employed with mixed fortunes in attempts to (re)solve the urban problems in the study area. Making use of a thematic approach and technique, the major urbanisation issues are explored and solutions proffered. Recommendations revolve around the need to implement robust and progressive rafts of projects, programmes, activities, measures and actions to reverse spatial fragmentation and spatially inefficient transport induced and perpetuated disadvantages.",book:{id:"7470",slug:"an-overview-of-urban-and-regional-planning",title:"An Overview of Urban and Regional Planning",fullTitle:"An Overview of Urban and Regional Planning"},signatures:"James Chakwizira, Peter Bikam and Thompson A. 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A smart city is one of the burning topics of research. Although there is no particular definition of a smart city, it means smart grid, e-health, e-environmental monitoring, smart home, smart water quality, smart air quality, etc. integrated into a single application. Human civilization can’t be sustained and prosper with shortage of usable water. Hence, water has a vital share in human life even for those living in smart cities. This chapter describes about the smart water quality issues in a smart city and some of the research advances in handling those issues. Among them it investigates the rainwater harvesting technologies and some of their practical applications.",book:{id:"7624",slug:"smart-urban-development",title:"Smart Urban Development",fullTitle:"Smart Urban Development"},signatures:"Raseswari Pradhan and Jayaprakash Sahoo",authors:null},{id:"62066",title:"Urban Planning and Mega-Event Projects: Lessons from Expo 2010, Shanghai",slug:"urban-planning-and-mega-event-projects-lessons-from-expo-2010-shanghai",totalDownloads:1327,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"With the capitalist transformation from Fordist-Keynesianism to neoliberalism, mega-events such as Olympic Games and World Exposition have increasingly been incorporated into urban development plan to boost urban renewal. Seeking the role of mega-event in urban transformation and its related effects have practical significance as mega-event movements have become a worldwide phenomenon. Although the profile of world fairs is reduced and does not have the international impacts that they used to have, Shanghai Expo 2010, the first Expo ever held in a developing country is pinned hope on as the “Turn to Save the World Expo” and is unusually ambitious to bring opportunities in urban transformation. While much attention has been paid to how mega-events can be used in tourism development in previous literature, this research links mega-event to urban development. Specifically, it reviews planning history before Expo 2010, addresses how a mega-event is integrated into city’s overall transformation strategy and what possible challenges a mega-event strategy may encounter related to the ultimate goal of urban transformation. It finds that political added value of mega-events empowers Shanghai to advance its urban agenda and the role of urban planner is vital to deliver a sustainable mega-event.",book:{id:"7470",slug:"an-overview-of-urban-and-regional-planning",title:"An Overview of Urban and Regional Planning",fullTitle:"An Overview of Urban and Regional Planning"},signatures:"Lingyue Li",authors:[{id:"247599",title:"Dr.",name:"Xx",middleName:null,surname:"Xx",slug:"xx-xx",fullName:"Xx Xx"}]},{id:"67808",title:"Understanding Urban Mobility and Pedestrian Movement",slug:"understanding-urban-mobility-and-pedestrian-movement",totalDownloads:1358,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Urban environments continue to expand and mutate, both in terms of size of urban area and number of people commuting daily as well as the number of options for personal mobility. City layouts and infrastructure also change constantly, subject to both short-term and long-term imperatives. Transportation networks have attracted particular attention in recent years, due to efforts to incorporate “green” options, enabling positive lifestyle choices such as walking or cycling commutes. In this chapter we explore the pedestrian viewpoint, aids to familiarity with and ease of navigation in the urban environment, and the impact of novel modes of individual transport (as options such as smart urban bicycles and electric scooters increasingly become the norm). We discuss principal factors influencing rapid transit to daily and leisure destinations, such as schools, offices, parks, and entertainment venues, but also those which facilitate rapid evacuation and movement of large crowds from these locations, characterized by high occupation density or throughput. The focus of the chapter is on understanding and representing pedestrian behavior through the agent-based modeling paradigm, allowing both large numbers of individual actions with active awareness of the environment to be simulated and pedestrian group movements to be modeled on real urban networks, together with congestion and evacuation pattern visualization.",book:{id:"7624",slug:"smart-urban-development",title:"Smart Urban Development",fullTitle:"Smart Urban Development"},signatures:"Marija Bezbradica and Heather J. Ruskin",authors:null},{id:"63405",title:"Restructuring Gauteng City Region in South Africa: Is a Transportation Solution the Answer?",slug:"restructuring-gauteng-city-region-in-south-africa-is-a-transportation-solution-the-answer-",totalDownloads:1855,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"The Gauteng city region forms the economic hub of socio-economic development and growth in South Africa. The province itself includes the Johannesburg metropolitan city, Ekurhuleni metropolitan city as well as Tshwane municipality—key urban growth regions of Gauteng province, South Africa, and by extension Southern Africa. The region exhibits the rapid urbanisation challenges typical in any developing country city. Rural–urban migration, pressure on infrastructure demand, supply and capacity constraints and mismatches in urban governance structures with respect to service delivery have remained stubborn challenges. Initiatives and strategies to resolve urban traffic congestion such as through road construction and highway expansion (physical instrument), e-tolling of roads (financial instrument), innovative housing and waste management technology deployment (technology instruments) as well as presenting advanced spatial planning and development and management systems (planning and regulatory instruments) have been employed with mixed fortunes in attempts to (re)solve the urban problems in the study area. Making use of a thematic approach and technique, the major urbanisation issues are explored and solutions proffered. Recommendations revolve around the need to implement robust and progressive rafts of projects, programmes, activities, measures and actions to reverse spatial fragmentation and spatially inefficient transport induced and perpetuated disadvantages.",book:{id:"7470",slug:"an-overview-of-urban-and-regional-planning",title:"An Overview of Urban and Regional Planning",fullTitle:"An Overview of Urban and Regional Planning"},signatures:"James Chakwizira, Peter Bikam and Thompson A. 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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",