Complications encountered with modified Bassini technique [6].
\r\n\tThe planning and technology of the tunnel and underground structures is an important issue for building of the structure. Depending on the particulars of each project location and the construction time available, the adopted construction methods have an important influence on the success of the project. Traditional and novel methods are underlined with the focus on reliable and cost effective technology.
\r\n\tOnce built, the tunnel needs to guarantee comfort to the users and reduce the risks of accident. The equipment is important to obtain adequate visibility and reduced concentration of contaminants. For these purposes, an adequate lighting system and ventilation system are necessary. Ventilation is also crucial in the case of emergency conditions, as it used to control fire development and smoke propagation. Operational and safety systems are to be analysed to fulfill the all the operational and emergency needs. The book investigates the relevant topics in these regards as the crucial point of tunnel exploitation.
\r\n\tThe aim of the book in focused also on the aspect of the optimised maintenance strategy of tunnels that bases on a systematic condition assessment through the investigations. Operation and maintenance works in tunnels have an adverse effect on the traffic, hence it is essential to plan operation and maintenance works rationally and effectively as the maintenance have to minimise the impact on the daily traffic and to ensure cost effectiveness at all times.
Inguinal hernia is one of the common surgical pathologies. A better understanding of the anatomy of the inguinal canal improved the surgical techniques and the outcomes for the patients. Developed countries are well organized in scientific societies enhancing these improvements. Instead, the sub-Saharan countries do not have specialized centers which will help by improving the hernia surgery [1] and the general surgeon’s training. The problematic of hernia surgery here is double, the improvement of inexpensive safe techniques and training of the general surgeons. This chapter emphasizes on two tension-free repair techniques, Desarda and modified Bassini, which are currently used for their low cost and are easily learned by the surgeons [2].
Bassini developed his hernia repair in 1887, which was minutely described by his student Catterina in 1930. This technique is the one currently used by general surgeon in secondary and tertiary hospitals in sub-Saharan countries. A modified Bassini was introduced, described as an autologous patch. The intervention can be under general or locoregional anesthesia. The description below is a modified Bassini technique by Atah [3].
A semi-Pfannenstiel incision is done homolateral to the hernia, for an esthetic scar. The inguinal canal opening is performed parallel to the inguinal ligament and the conjoint tendon through the superficial fascia and deep fascia; the external oblique aponeurosis (EOA) is cut. The EOA cut is extended to the superficial inguinal ring. The spermatic cord is opened layer by layer, and the hernia sac is exposed, dissected, and resected.
Through the inguinal canal, the internal oblique tendon and the transverse tendon are united to form the joint tendon or separated. Those muscle fibers are parallel to the external oblique muscle, which is behind them. The conjoint tendon or the internal oblique tendon is easily used to strengthen the inguinal canal.
The herniorrhaphy is made with the inguinal ligament left in its normal position without being dissected and sutured to the conjoint tendon with number 1 or 0 Polyglactin 910 rounded overlock suture. The suture begins at the pubic tubercle to the deep inguinal ring. The free leaf of the conjoint tendon is sutured to the inferior part of the inguinal ligament, behind the spermatic cordon following the retro-funicular Bassini technique.
The diameter of the deep inguinal ring is reduced with a separate point, to admit only the tip of the little finger, enough caring not to strangulate the spermatic cordon in male or the round ligament in female. If the repair is under tension, a discharge incision is done, and the two borders are sutured to the EOA with number 1 or 0 Polyglactin 910 interrupted sutures. The skin closure is done.
The Desarda hernia repair, eponym name to its author, described in 2001, is an autologous hernioplasty. The technique was developed as a tension-free hernia repair without mesh, to reduce the chronic groin pain, recovery time, and cost [4]. The intervention can be performed under general anesthesia or locoregional anesthesia.
The skin incision is a 6 cm oblique at the level of the inferior abdominal line or the Malgaigne’s line (Figure 1). The fascia is incised and the EOA exposed. The EOA is cut in line with the inguinal ligament and the upper crux of the superficial ring, with a medial leaf and lateral leaf (Figure 2).
Skin incision.
External oblique aponeurosis incision.
A direct or indirect hernia, with or without a sac, can be found. The cremaster muscle is resected, and the hernia sac dissected in the direction of the deep inguinal ring protecting the spermatic cord (Figure 3). The sac is ligatured with a resorbable thread USP 2/0 and excised in an indirect hernia and inverted in a direct hernia.
Hernia sac dissection.
The fascial plasty starts with the medial leaf of the EOA which is sutured with the inguinal ligament from the pubic tubercle to the abdominal ring using number 2/0 or 0 Monofilament Polydioxanone continuous sutures (Figure 4). The first two sutures were taken through the anterior rectus sheath, and the last suture is taken to narrow the abdominal ring sufficiently, caring not to strangulate the spermatic cord.
Suture of the medial leaf of the EOA to the inguinal ligament.
An incision is made on the sutured medial leaf to obtain an aponeurosis flap of 1–2 cm (Figure 5). This fascial flap is extended medially up to the pubic symphysis and 2 cm beyond the abdominal ring laterally.
Incision of the sutured medial leaf of the EOA.
The upper free border of the aponeurosis flap is sutured to the internal oblique muscle at the level of the conjoint tendon with a number 2/0 or 0 Monofilament Polydioxanone continuous suture (Figure 6). With these sutures of the EOA, a new posterior wall of the inguinal canal is formed behind the spermatic cord. After the suture of the EOA, the patient is asked to cough or strain if it is under locoregional anesthesia, and under general anesthesia the anesthetist is asked to give a deep breath to the patient; this is to verify the solidity of the new posterior wall.
Suture of the upper free border of the aponeurosis flap.
The spermatic cord is replaced in the inguinal canal; the lateral leaf of the EOA is sutured to the new medial leaf of the EOA with a number 2/0 Monofilament Polydioxanone continuous sutures (Figure 7).
Suture of the lateral leaf of the EOA to the new medial leaf of the EOA.
The EOA is sutured forward the spermatic cord (Figure 8), and a classic closure of the superficial fascia and the skin is done.
Closure of the EOA.
The recurrence rate after an inguinal hernia repair is difficult to determine because of the high percentage of loss to follow-up. But some studies have shown that the modified Bassini technique is the most commonly used or the inguinal hernia repair [5]. This could be explained by the fact that surgeons in most of the peripheral hospitals are using tissue repair, mainly due to the limited resources of the population [6].
However, some complications occur with the tissue repair. Complications encountered in patient follow-up after a modified Bassini hernia repair are multiple; a prospective study in a rural hospital including 300 male patients highlighted some of them (Table 1).
Complications | Incidence (%) |
---|---|
Urine retention | 5 (2.07) |
Hematoma (superficial) | 1 (0.41) |
Wound infection | 1 (0.41) |
Seroma | 2 (0.83) |
Postoperative neuralgia | 3 (1.24) |
Scrotal edema | 2 (0.83) |
Ischemic orchitis | 0 (0.00) |
Recurrence | 2 (0.83) |
Complications encountered with modified Bassini technique [6].
The same complications can be observed with the Desarda technique as shown in a prospective study of 2 years, with 100 patients (Table 2) [7].
Complications | Incidence (%) |
---|---|
Urine retention | 3 (0.03) |
Wound infection | 4 (0.04) |
Vomiting | 2 (0.02) |
Acute postoperative pain | 32 (0.32) |
Chronic postoperative pain after 3 months | 4 (0.01) |
Scrotal edema | 2 (0.02) |
Recurrence from 3 to 27 months | 0 (0.00) |
Complications encountered with Desarda technique.
The two techniques are cost inexpensive, with a low rate of recurrence of the hernia and postoperative pain.
The European Hernia Society (EHS) gold standard regarding open tension-free hernia repair is the Lichtenstein mesh repair. However complications associated with it includes an important rate of mesh-related infection as wound infection due in some cases to an allergic reaction, mesh migration, and nerve entrapment [8]. These complications can lead to a prolonged hospital stay and a long treatment with antibiotics. Using Desarda or modified Bassini techniques avoid the risk of mesh-related complications, which would be an extra cost for the patient.
Inguinal hernia treatment depends also on the surgeon training and experiences. There are several tension-free techniques describe with or without mesh. Another goal in the management of hernias is the training of surgeons, depending on the medical and socioeconomic context.
Inguinal hernia is one of the commonest surgical pathology. In sub-Saharan Africa, it should be considered as a public health disease, to improve its management. The socioeconomic context is important here to consider the choice of the hernia repair technique. The tension-free repairs without mesh, Desarda and modified Bassini, response well to the economic criteria, with the advantages of a low rate of recurrence, postoperative pain, and reduced hospital stay.
The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this manuscript.
The Republic of Suriname is a small independent country in South America that is renowned for its ethnic, cultural, and religious diversity [1]. The Javanese are currently the fourth most numerous ethnic group in Suriname, after the Hindustanis, the Creoles, and the Maroons [1]. The Javanese are the descendants of indentured laborers from particularly the Indonesian island of Java who were attracted by the Dutch colonizers from the former Dutch East Indies - modern-day Indonesia - at the end of the 19th century to work on the sugar cane plantations in Suriname following the abolition of slavery in the year 1863 [2, 3]. They had signed contracts for five years, and although some returned to their home country and others relocated to The Netherlands [2, 3], most remained in Suriname and settled in the district of Commewijne where the first groups of Javanese had been put to work [2, 3].
Today, only five generations later, the Javanese have integrated well in Suriname, actively participating in all sections of the society including politics, arts, entertainment, and sports. For instance, Iding and Willy Soemita and Paul Somohardjo were prominent Surinamese Javanese politicians. Iding Soemita was born in West Java and came as an indentured laborer to Suriname, and founded the political party
The Surinamese-Javanese writer Karin Amatmoekrim studied Modern Literature at the University of Amsterdam, graduated with a thesis on ‘The ethnicity in literature in Suriname’, and won the 2009-Black Magic Woman Literature Prize for her novel ‘Titus’. The Surinamese-Javanese singers Ragmad Amatstam, Oesje Soekatma, and Eddy Assan are among the greatest and most beloved musicians Suriname has brought forth. Specializing in pop-Jawa songs, they reached a broad audience in both Suriname and The Netherlands. Notable Surinamese-Javanese sports heroes are Andy Atmodimedjo, Virgil Soeroredjo, and Mitchel Wongsodikromo. Andy Atmodimedjo was an impressive professional football player and became the successful manager of several clubs in Suriname’s highest soccer league as well as the head coach of the country’s senior and under-21 national soccer teams. And Virgil Soeroredjo and Mitchel Wongsodikromo were among the world’s top badminton players who excelled on various national, Caribbean, Central American, and South American competitions.
Nevertheless, the Javanese have preserved their own identity, speaking their own language and adhering to their own specific religious and cultural customs. This also holds true for their traditional medical customs which are based on
Hereunder, six medicinal plants that are traditionally mainly used by Surinamese Javanese - in addition to four that have been addressed in the first part of this chapter - have in detail been assessed for their phytochemical contents and pharmacological activities in order to provide a scientific rationale for their ethnopharmacological applications. The plants have been selected on the basis of the number of times they have been dealt with in a number of comprehensive publications describing the use of medicinal plants in the country [4, 5, 6, 7, 8, 9, 10, 11, 12]. All the ten plants and their main traditional use by Surinamese Javanese have been given in Table 1.
Family | Species (vernacular names in English; Surinamese-Javanese) | Part(s) used | Traditional indications | References |
---|---|---|---|---|
Acanthaceae | Leaf | Disorders of the urinary system, diabetes mellitus | [8] | |
Araceae | Rhizome | Gastrointestinal disorders, intestinal parasites, common cold, convulsions and seizures in children, evil eye and evil spirits | [7, 8, 12] | |
Arecaceae | Coconut oil, coconut meat, coconut water, husk fibers | Respiratory problems, pimples, shingles due to herpes, diabetes mellitus, hypertension, gastrointestinal disorders, skin and hair care, skin lesions, burns, sprains, sore muscles, evil eye and luck | [6, 7, 8, 9, 10] | |
Asclepiadaceae | Latex, stem | Bleeding, skin lesions, burns, toothache, tonsillitis, colds, heart conditions | [10, 12] | |
Asteraceae | Whole plant, leaf, root | Symptioms of flu, gastrointestinal problems, gynecological disorders, gonorrhea, itching, skin lesions, burns, allergic conjunctivitis | [6, 9, 11, 12] | |
Caesalpiniaceae | Leaf, fruit pulp | Health-promoting | [4, 8, 12] | |
Fabaceae | Leaf, bark | Abdominal disorders, throat and oral infections | [12] | |
Portulacaceae | Whole plant, leaf | Skin lesions, sprains, swellings, stiff joints, pain, bronchitis, conjunctivitis, anemia | [5, 9, 12] | |
Zingiberaceae | Rhizome | Health-promoting | [8, 12] | |
Zingiberaceae | Rhizome | Health-promoting | [8, 12] |
Plants commonly used in Javanese traditional medicine addressed in this chapter, parts preferentially used, and traditional indications in the Surinamese-Javanese community.
The goat weed
The goat weed
In Suriname, an infusion from the whole plant is drunk against a sore throat, colics, and atony of the digestive tract [11], as well as gynecological diseases and gonorrhea [9]. A tea prepared from the root as well as the juice from the leaf are also used against a sore throat and, in addition, for reducing fever and fighting colds [12]. Itching all over the body, diarrhea, and chest conditions are treated by drinking a tea from the leaves [6]. A concentrated leaf decoction is used against chiggers [17], the juvenile forms of a type of mite (Trombiculidae) that are also known as berry bugs and that produces itching and blisters on the skin [18]. An infusion from the leaves is externally used against allergic conjunctivitis [6]. And a paste from the crushed leaves is applied on abscesses or burn wounds [6].
Most of the traditional uses and supporting pharmacological activities of
The use of preparations from
Indications for antiiflammatory effects of
Support for antimicrobial activities of
The analgesic, antiinflammatory, antimicrobial, and wound healing properties of
The tamarind
The tamarind
The incorporation of
Indications for weight-reducing properties of
The use of
Further support for the traditional uses of
The claims of efficacy of
The vegetable hummingbird
The vegetable hummingbird
Phytochemical studies revealed the presence of several bioactive in
Pharmacological support for the use of a concoction from
The use of the leaf juice against conditions of the throat and the oral cavity [12] may be accounted for by the antibacterial and wound healing activity of this preparation. Support for the former suggestion came from the notable activity of extracts from the leaf - but also from the stembark, the flower, and other parts of the plant - against a variety of bacterial strains [66, 67, 68]. The antimicrobial activity was most prominent with extracts prepared with organic solvents [66, 67, 68] and was also directed against methicillin-resistant
Indications for wound healing activity of
The green purslane
The green purslane
Some of the traditional uses may be associated with the presence in the plant of potent bioactive compounds such as flavonoids and alkaloids [77, 78]. Some of the flavonoids have been associated with antibacterial, antiviral, antiinflammatory, and/or antioxidant activities of the plant [77, 78, 79]. Potent alkaloids identified in the plant are dopa, dopamine, and noradrenalin as well as oleracimines which have been associated with the antiinflammatory properties of the plant [77, 78, 80].
The apparent usefulness of
Indications for antiinflammatory and analgesic activities of
Indications for antioxidant activity of
The turmeric
The turmeric
The main constituents of
Several lines of evidence support the inclusion of
The usefulness of
These apparent antiinflammatory activities of
The aseptic properties of
The ginger
The ginger
The distinctive odor and flavor of
Both gingerols and shogaols exhibit a host of biological activities [129, 130], supporting some of the traditional claims of
Furthermore, crude rhizome methanol extracts elicited potent positive-inotropic effects in an isolated guinea pig left atria preparation [135]. These extract also induced a dose-dependent fall in blood pressure in anesthetized rats, inhibited the spontaneous force and beating rate of atrial contractions in guinea pig atria similarly to the calcium antagonist verapamil, and caused endothelium-independent vasodilation in rabbit and rat aorta [136]. These apparent cardiotonic activities have been ascribed to the gingerols and the shogaols in the preparations [125, 136]. Additional support for the inclusion of
The folkloristic use of
Several pieces of evidence support the traditional use of
The Javanese have been in Suriname for over a century. They have been brought to that country as poor and unaccustomed indentured laborers but have become successful individuals who have integrated well into the Surinamese community, actively participating in all its sections. Indeed, the Javanese are full-fledged citizens of the country and an integral part of the vibrant color palette represented by its unique cultural, religious, and ethnic diversity. This is reflected by the presence of the small, often family-owned Javanese restaurants called
Nevertheless, the Javanese have maintained most of their cultural traditions. This particularly holds true for their ancient form of medicine that is based on centuries-old
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She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334239",title:"Prof.",name:"Leung",middleName:null,surname:"Wai Keung",slug:"leung-wai-keung",fullName:"Leung Wai Keung",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Hong Kong",country:{name:"China"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},onlineFirstChapters:{paginationCount:13,paginationItems:[{id:"82409",title:"Purinergic Signaling in Covid-19 Disease",doi:"10.5772/intechopen.105008",signatures:"Hailian Shen",slug:"purinergic-signaling-in-covid-19-disease",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82096",title:"An Important Component of Tumor Progression: Fatty Acids",doi:"10.5772/intechopen.105087",signatures:"Jin Wang, Qifei Wang and Guangzhen Wu",slug:"an-important-component-of-tumor-progression-fatty-acids",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - 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