More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\n
Additionally, each book published by IntechOpen contains original content and research findings.
\\n\\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\n
Simba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\n
IntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\n
Since the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\n
Additionally, each book published by IntechOpen contains original content and research findings.
\n\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n
\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"1852",leadTitle:null,fullTitle:"Visions for Global Tourism Industry - Creating and Sustaining Competitive Strategies",title:"Visions for Global Tourism Industry",subtitle:"Creating and Sustaining Competitive Strategies",reviewType:"peer-reviewed",abstract:"We have been witnessing huge competition among the organisations in the business world. Companies, NGO's and governments are looking for innovative ways to compete in the global tourism market. In the classical literature of business the main purpose is to make a profit. However, if purpose only focus on the profit it will not to be easy for them to achieve. Nowadays, it is more important for organisations to discover how to create a strong strategy in order to be more competitive in the marketplace. Increasingly, organisations have been using innovative approaches to strengthen their position. Innovative working enables organisations to make their position much more competitive and being much more value-orientated in the global tourism industry. In this book, we are pleased to present many papers from all over the world that discuss the impact of tourism business strategies from innovative perspectives. This book also will help practitioners and academician to extend their vision in the light of scientific approaches.",isbn:null,printIsbn:"978-953-51-0520-6",pdfIsbn:"978-953-51-5120-3",doi:"10.5772/2278",price:139,priceEur:155,priceUsd:179,slug:"visions-for-global-tourism-industry-creating-and-sustaining-competitive-strategies",numberOfPages:492,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"e5750e9145b14c8354ef9bd0b4097316",bookSignature:"Murat Kasimoglu",publishedDate:"April 18th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/1852.jpg",numberOfDownloads:123805,numberOfWosCitations:111,numberOfCrossrefCitations:86,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:166,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:363,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 30th 2011",dateEndSecondStepPublish:"June 27th 2011",dateEndThirdStepPublish:"November 1st 2011",dateEndFourthStepPublish:"December 1st 2011",dateEndFifthStepPublish:"March 30th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"115863",title:"Dr.",name:"Murat",middleName:null,surname:"Kasimoglu",slug:"murat-kasimoglu",fullName:"Murat Kasimoglu",profilePictureURL:"https://mts.intechopen.com/storage/users/115863/images/5511_n.jpg",biography:"Dr. Murat Kasimoğlu is a professor of management. He received his doctorate degree from the Istanbul University, Faculty of Business. He worked on management projects with companies, NGOs for various organizations in the tourism industry. He teaches Management, Business Strategy at the Undergraduate, Graduate and Doctorate levels. He has given lectures at various universities in EU and some developing countries (Slovakia, Azerbaijan, ets). He also attended international conferences and published papers in international journals. He has developed strategic partnership around the world. He also joined international programs for developing global strategies.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"445",title:"Strategic Management",slug:"business-management-and-economics-business-administration-strategic-management"}],chapters:[{id:"35517",title:"Sustainable Tourism – A Model Approach",doi:"10.5772/37718",slug:"sustainable-tourism-a-modeling-approach",totalDownloads:7187,totalCrossrefCites:8,totalDimensionsCites:10,hasAltmetrics:0,abstract:null,signatures:"Leszek Butowski",downloadPdfUrl:"/chapter/pdf-download/35517",previewPdfUrl:"/chapter/pdf-preview/35517",authors:[{id:"114047",title:"Ph.D.",name:"Leszek",surname:"Butowski",slug:"leszek-butowski",fullName:"Leszek Butowski"}],corrections:null},{id:"35518",title:"Knowledge-Based Decisions in Tourism",doi:"10.5772/37623",slug:"knowledge-based-decisions-in-tourism",totalDownloads:2423,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Diana Târnăveanu",downloadPdfUrl:"/chapter/pdf-download/35518",previewPdfUrl:"/chapter/pdf-preview/35518",authors:[{id:"113554",title:"Dr.",name:"Diana",surname:"Tarnaveanu",slug:"diana-tarnaveanu",fullName:"Diana Tarnaveanu"}],corrections:null},{id:"35519",title:"Introduction to Input-Output Framework for Analysis of Tourism as an Industry",doi:"10.5772/37109",slug:"input-output-modeling-as-a-tool-for-measurement-of-economic-impacts-of-tourism-as-an-industry",totalDownloads:7105,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:null,signatures:"Tadayuki (Tad) Hara",downloadPdfUrl:"/chapter/pdf-download/35519",previewPdfUrl:"/chapter/pdf-preview/35519",authors:[{id:"111309",title:"Dr.",name:"Tadayuki",surname:"Hara",slug:"tadayuki-hara",fullName:"Tadayuki Hara"}],corrections:null},{id:"35520",title:"Golden Age of Mass Tourism: Its History and Development",doi:"10.5772/37283",slug:"mass-tourism-its-history-and-development-in-the-golden-age",totalDownloads:22084,totalCrossrefCites:10,totalDimensionsCites:13,hasAltmetrics:0,abstract:null,signatures:"Erkan Sezgin and Medet Yolal",downloadPdfUrl:"/chapter/pdf-download/35520",previewPdfUrl:"/chapter/pdf-preview/35520",authors:[{id:"112080",title:"Dr.",name:"Erkan",surname:"Sezgin",slug:"erkan-sezgin",fullName:"Erkan Sezgin"},{id:"140397",title:"Dr.",name:"Medet",surname:"Yolal",slug:"medet-yolal",fullName:"Medet Yolal"}],corrections:null},{id:"35521",title:"Recent Developments in Research and Future Directions of Culinary Tourism: A Review",doi:"10.5772/38142",slug:"recent-developments-in-research-and-future-directions-of-culinary-tourism-a-review-",totalDownloads:6563,totalCrossrefCites:6,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Ching-Shu Su and Jeou-Shyan Horng",downloadPdfUrl:"/chapter/pdf-download/35521",previewPdfUrl:"/chapter/pdf-preview/35521",authors:[{id:"115775",title:"PhD.",name:"Ching-Shu",surname:"Su",slug:"ching-shu-su",fullName:"Ching-Shu Su"}],corrections:null},{id:"35522",title:"Enterprise Proportionalities in the Tourism Sector of South African Towns",doi:"10.5772/37319",slug:"enterprise-proportionalities-in-the-tourism-sector-of-south-african-towns",totalDownloads:1714,totalCrossrefCites:0,totalDimensionsCites:6,hasAltmetrics:0,abstract:null,signatures:"Daan Toerien",downloadPdfUrl:"/chapter/pdf-download/35522",previewPdfUrl:"/chapter/pdf-preview/35522",authors:[{id:"109200",title:"Dr.",name:"Daan",surname:"Toerien",slug:"daan-toerien",fullName:"Daan Toerien"}],corrections:null},{id:"35523",title:"New Opportunities for the Tourism Market: Senior Tourism and Accessible Tourism",doi:"10.5772/38092",slug:"new-opportunities-for-the-tourism-market-senior-tourism-and-accessible-tourism",totalDownloads:16650,totalCrossrefCites:19,totalDimensionsCites:47,hasAltmetrics:0,abstract:null,signatures:"Elisa Alén, Trinidad Domínguez and Nieves Losada",downloadPdfUrl:"/chapter/pdf-download/35523",previewPdfUrl:"/chapter/pdf-preview/35523",authors:[{id:"115524",title:"Dr.",name:"Elisa",surname:"Alen",slug:"elisa-alen",fullName:"Elisa Alen"},{id:"118677",title:"Dr.",name:"Trinidad",surname:"Dominguez",slug:"trinidad-dominguez",fullName:"Trinidad Dominguez"},{id:"118678",title:"MSc.",name:"Nieves",surname:"Losada",slug:"nieves-losada",fullName:"Nieves Losada"}],corrections:null},{id:"35524",title:"The Role of Time in the Global Tourism Market - A Demand Perspective",doi:"10.5772/38825",slug:"-the-role-of-time-in-the-global-tourism-market-a-demand-perspective",totalDownloads:2618,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Grzegorz Gołembski and Agnieszka Niezgoda",downloadPdfUrl:"/chapter/pdf-download/35524",previewPdfUrl:"/chapter/pdf-preview/35524",authors:[{id:"119760",title:"Dr.",name:null,surname:"Gotembski",slug:"gotembski",fullName:"Gotembski"}],corrections:null},{id:"35525",title:"Mature Tourist Destination: A New Tool to Forecast Internal Composition of Its Demand",doi:"10.5772/37804",slug:"mature-tourist-destination-a-new-tool-to-forecast-internal-composition-of-its-demand",totalDownloads:2672,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Montserrat Hernández-López",downloadPdfUrl:"/chapter/pdf-download/35525",previewPdfUrl:"/chapter/pdf-preview/35525",authors:[{id:"114413",title:"Dr.",name:"Montserrat",surname:"Hernandez-Lopez",slug:"montserrat-hernandez-lopez",fullName:"Montserrat Hernandez-Lopez"}],corrections:null},{id:"35526",title:"Security Measures on the International Tourism",doi:"10.5772/37178",slug:"security-measures-on-the-international-tourism-industry-",totalDownloads:2353,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Jesús E. Martínez Marín",downloadPdfUrl:"/chapter/pdf-download/35526",previewPdfUrl:"/chapter/pdf-preview/35526",authors:[{id:"111623",title:"Dr.",name:"Jesus",surname:"Martinez Marin",slug:"jesus-martinez-marin",fullName:"Jesus Martinez Marin"}],corrections:null},{id:"35527",title:"Heritages and Transformations of Agrarian Structures and the Rural Tourism Dynamic in the Czech Republic",doi:"10.5772/38806",slug:"inheritances-changes-in-agrarian-structures-and-rural-tourism-dynamics-in-czech-republic",totalDownloads:1473,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Pascal Chevalier",downloadPdfUrl:"/chapter/pdf-download/35527",previewPdfUrl:"/chapter/pdf-preview/35527",authors:[{id:"119530",title:"Dr.",name:"Chevalier",surname:"Pascal",slug:"chevalier-pascal",fullName:"Chevalier Pascal"}],corrections:null},{id:"35528",title:"Using Weather-Related Derivative Products for Tourism and Hospitality Businesses",doi:"10.5772/38932",slug:"using-weather-derivatives-for-tourism-and-hospitality-businesses-",totalDownloads:1924,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"M. Fuat Beyazit and Erdogan Koc",downloadPdfUrl:"/chapter/pdf-download/35528",previewPdfUrl:"/chapter/pdf-preview/35528",authors:[{id:"123323",title:"Dr.",name:"Fuat",surname:"Beyazit",slug:"fuat-beyazit",fullName:"Fuat Beyazit"},{id:"137258",title:"Dr.",name:"Erdogan",surname:"Koc",slug:"erdogan-koc",fullName:"Erdogan Koc"}],corrections:null},{id:"35529",title:"Tourism Life Cycle Assessment (LCA): Proposal of a New Methodological Framework for Sustainable Consumption and Production",doi:"10.5772/23550",slug:"tourism-life-cycle-assessment-lca-a-new-methodological-framework-for-sustainable-consumption-and-pro",totalDownloads:6948,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:null,signatures:"Camillo De Camillis, Paul Peeters, Luigia Petti and Andrea Raggi",downloadPdfUrl:"/chapter/pdf-download/35529",previewPdfUrl:"/chapter/pdf-preview/35529",authors:[{id:"120456",title:"Dr.",name:"Camillo",surname:"De Camillis",slug:"camillo-de-camillis",fullName:"Camillo De Camillis"},{id:"120458",title:"Prof.",name:"Paul",surname:"Peeters",slug:"paul-peeters",fullName:"Paul Peeters"},{id:"120459",title:"Prof.",name:"Luigia",surname:"Petti",slug:"luigia-petti",fullName:"Luigia Petti"},{id:"120460",title:"Prof.",name:"Andrea",surname:"Raggi",slug:"andrea-raggi",fullName:"Andrea Raggi"}],corrections:null},{id:"35530",title:"Economic Impact of Tourism - A Review of Literatures on Methodologies and Their Uses: 1969-2011",doi:"10.5772/38635",slug:"economic-impact-of-tourism-a-review-of-literatures-on-methodologies-and-their-uses-1969-2009",totalDownloads:8180,totalCrossrefCites:1,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Mohammad Nurul Huda Mazumder, Abdullah Al-Mamun, Abul Quasem Al-Amin and Muhammad Mohiuddin",downloadPdfUrl:"/chapter/pdf-download/35530",previewPdfUrl:"/chapter/pdf-preview/35530",authors:[{id:"118439",title:"Mr.",name:"Mohammad",surname:"Mazumder",slug:"mohammad-mazumder",fullName:"Mohammad Mazumder"},{id:"138029",title:"Mr.",name:"Abdullah",surname:"Al-Mamun",slug:"abdullah-al-mamun",fullName:"Abdullah Al-Mamun"},{id:"138030",title:"Dr.",name:"Abul Quasem",surname:"Al-Amin",slug:"abul-quasem-al-amin",fullName:"Abul Quasem Al-Amin"},{id:"138031",title:"Mr.",name:"Muhammad",surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],corrections:null},{id:"35531",title:"Carrying Capacity of Tourism System: Assessment of Environmental and Management Constraints Towards Sustainability",doi:"10.5772/38750",slug:"carrying-capacity-of-tourism-system-assessment-of-environmental-and-management-constraints-towards-s",totalDownloads:4994,totalCrossrefCites:7,totalDimensionsCites:14,hasAltmetrics:0,abstract:null,signatures:"Valentina Castellani and Serenella Sala",downloadPdfUrl:"/chapter/pdf-download/35531",previewPdfUrl:"/chapter/pdf-preview/35531",authors:[{id:"119162",title:"Dr.",name:"Serenella",surname:"Sala",slug:"serenella-sala",fullName:"Serenella Sala"},{id:"119278",title:"Dr.",name:"Valentina",surname:"Castellani",slug:"valentina-castellani",fullName:"Valentina Castellani"}],corrections:null},{id:"35532",title:"Reputational Damage to Tourism Industry from Earthquakes - Impact and Analysis of Mass Media Information",doi:"10.5772/38228",slug:"harmful-rumor-on-tourism-industry-caused-by-earthquake-impact-of-mass-media-information-and-analysis",totalDownloads:3788,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Mitsuyoshi Nagao and Azuma Ohuchi",downloadPdfUrl:"/chapter/pdf-download/35532",previewPdfUrl:"/chapter/pdf-preview/35532",authors:[{id:"116129",title:"Dr.",name:"Mitsuyoshi",surname:"Nagao",slug:"mitsuyoshi-nagao",fullName:"Mitsuyoshi Nagao"}],corrections:null},{id:"35533",title:"The Tourist Potential of the Minho-Lima Region (Portugal)",doi:"10.5772/38197",slug:"the-tourism-potential-of-the-minho-lima-northern-portugal-region-",totalDownloads:2235,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"José Cadima Ribeiro and Laurentina Cruz Vareiro",downloadPdfUrl:"/chapter/pdf-download/35533",previewPdfUrl:"/chapter/pdf-preview/35533",authors:[{id:"115965",title:"Prof.",name:"José",surname:"Cadima Ribeiro",slug:"jose-cadima-ribeiro",fullName:"José Cadima Ribeiro"},{id:"118377",title:"PhD.",name:"Laurentina",surname:"Vareiro",slug:"laurentina-vareiro",fullName:"Laurentina Vareiro"}],corrections:null},{id:"35534",title:"Long-Term Impacts of Non-Sustainable Tourism and Urban Development in Small Tropical Islands Coastal Habitats in a Changing Climate: Lessons Learned from Puerto Rico",doi:"10.5772/38140",slug:"long-term-impacts-of-non-sustainable-tourism-and-urban-development-in-tropical-coastal-habitats-in-a",totalDownloads:5343,totalCrossrefCites:8,totalDimensionsCites:11,hasAltmetrics:0,abstract:null,signatures:"Edwin A. Hernández- Delgado, Carlos E. Ramos-Scharrón, Carmen R. Guerrero-Pérez, Mary Ann Lucking, Ricardo Laureano, Pablo A. Méndez-Lázaro and Joel O. Meléndez-Díaz",downloadPdfUrl:"/chapter/pdf-download/35534",previewPdfUrl:"/chapter/pdf-preview/35534",authors:[{id:"105547",title:"Dr.",name:"Carlos",surname:"Ramos-Scharron",slug:"carlos-ramos-scharron",fullName:"Carlos Ramos-Scharron"},{id:"108403",title:"Dr.",name:"Edwin",surname:"Hernandez- Delgado",slug:"edwin-hernandez-delgado",fullName:"Edwin Hernandez- Delgado"},{id:"118359",title:"BSc.",name:"Mary Ann",surname:"Lucking",slug:"mary-ann-lucking",fullName:"Mary Ann Lucking"},{id:"118360",title:"Mr.",name:"Ricardo",surname:"Laureano",slug:"ricardo-laureano",fullName:"Ricardo Laureano"},{id:"151525",title:"MSc.",name:"Carmen",surname:"Guerrero-Perez",slug:"carmen-guerrero-perez",fullName:"Carmen Guerrero-Perez"},{id:"151526",title:"Dr.",name:"Pablo",surname:"Mendez-Lazaro",slug:"pablo-mendez-lazaro",fullName:"Pablo Mendez-Lazaro"}],corrections:null},{id:"35535",title:"Nautical Tourism and Its Function in the Economic Development of Europe",doi:"10.5772/38058",slug:"nautical-tourism-in-the-function-of-the-economic-development-of-europe",totalDownloads:6130,totalCrossrefCites:18,totalDimensionsCites:28,hasAltmetrics:0,abstract:null,signatures:"Tihomir Luković",downloadPdfUrl:"/chapter/pdf-download/35535",previewPdfUrl:"/chapter/pdf-preview/35535",authors:[{id:"115398",title:"Dr.",name:"Tihomir",surname:"Lukovic",slug:"tihomir-lukovic",fullName:"Tihomir Lukovic"}],corrections:null},{id:"35536",title:"Sustainability in the Management of World Cultural Heritage",doi:"10.5772/37940",slug:"sustainability-in-the-management-of-world-cultural-heritage",totalDownloads:3250,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Devi Roza Kausar",downloadPdfUrl:"/chapter/pdf-download/35536",previewPdfUrl:"/chapter/pdf-preview/35536",authors:[{id:"114864",title:"Dr.",name:"Devi",surname:"Kausar",slug:"devi-kausar",fullName:"Devi Kausar"}],corrections:null},{id:"35537",title:"Tourism in Rural Areas: Foundation, Quality and Experience",doi:"10.5772/37483",slug:"tourism-in-rural-areas-foundation-quality-and-experience",totalDownloads:4186,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Sandra Maria Correia Loureiro",downloadPdfUrl:"/chapter/pdf-download/35537",previewPdfUrl:"/chapter/pdf-preview/35537",authors:[{id:"112943",title:"Prof.",name:"Sandra",surname:"Loureiro",slug:"sandra-loureiro",fullName:"Sandra Loureiro"}],corrections:null},{id:"35538",title:"Islands and Tourism Development: A Viewpoint of Tourism Stakeholders of Lesvos Island",doi:"10.5772/37110",slug:"islands-and-tourism-development-a-viewpoint-of-tourism-stakeholders-of-lesvos-island-greece",totalDownloads:3989,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Kostas Rontos, Eleni Kitrinou, Dimitrios Lagos and Mihail Diakomihalis",downloadPdfUrl:"/chapter/pdf-download/35538",previewPdfUrl:"/chapter/pdf-preview/35538",authors:[{id:"111311",title:"Prof.",name:"Kostas",surname:"Rontos",slug:"kostas-rontos",fullName:"Kostas Rontos"},{id:"111729",title:"Prof.",name:"Mihail",surname:"Diakomihalis",slug:"mihail-diakomihalis",fullName:"Mihail Diakomihalis"},{id:"117320",title:"Dr.",name:"Eleni",surname:"Kitrinou",slug:"eleni-kitrinou",fullName:"Eleni Kitrinou"},{id:"117322",title:"Prof.",name:"Dimitrios",surname:"Lagos",slug:"dimitrios-lagos",fullName:"Dimitrios Lagos"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2298",title:"Strategies for Tourism Industry",subtitle:"Micro and Macro Perspectives",isOpenForSubmission:!1,hash:"756704471c1209186b420f9985bd4fa6",slug:"strategies-for-tourism-industry-micro-and-macro-perspectives",bookSignature:"Murat Kasimoglu and Handan Aydin",coverURL:"https://cdn.intechopen.com/books/images_new/2298.jpg",editedByType:"Edited by",editors:[{id:"115863",title:"Dr.",name:"Murat",surname:"Kasimoglu",slug:"murat-kasimoglu",fullName:"Murat Kasimoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"275",title:"Supply Chain Management",subtitle:"New Perspectives",isOpenForSubmission:!1,hash:"4916452247f0dca332b9c5ce44186819",slug:"supply-chain-management-new-perspectives",bookSignature:"Sanda Renko",coverURL:"https://cdn.intechopen.com/books/images_new/275.jpg",editedByType:"Edited by",editors:[{id:"40806",title:"Prof.",name:"Sanda",surname:"Renko",slug:"sanda-renko",fullName:"Sanda Renko"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1344",title:"Pathways to Supply Chain Excellence",subtitle:null,isOpenForSubmission:!1,hash:"5aa3ffa9fd74532ac088791640bcba64",slug:"pathways-to-supply-chain-excellence",bookSignature:"Ales Groznik and Yu Xiong",coverURL:"https://cdn.intechopen.com/books/images_new/1344.jpg",editedByType:"Edited by",editors:[{id:"22725",title:"Dr.",name:"Ales",surname:"Groznik",slug:"ales-groznik",fullName:"Ales Groznik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"232",title:"Supply Chain Management",subtitle:"Applications and Simulations",isOpenForSubmission:!1,hash:"b691bc5f6d9e959c3472eb2610e9d98f",slug:"supply-chain-management-applications-and-simulations",bookSignature:"Mamun Habib",coverURL:"https://cdn.intechopen.com/books/images_new/232.jpg",editedByType:"Edited by",editors:[{id:"12501",title:"Prof.",name:"Dr. Md. Mamun",surname:"Habib",slug:"dr.-md.-mamun-habib",fullName:"Dr. Md. Mamun Habib"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"471",title:"The Economic Geography of Globalization",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"the-economic-geography-of-globalization",bookSignature:"Piotr Pachura",coverURL:"https://cdn.intechopen.com/books/images_new/471.jpg",editedByType:"Edited by",editors:[{id:"33832",title:"Prof.",name:"Piotr",surname:"Pachura",slug:"piotr-pachura",fullName:"Piotr Pachura"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6180",title:"Positive and Negative Aspects of Outsourcing",subtitle:null,isOpenForSubmission:!1,hash:"bbb23ab7b6c01663b1764d8374602a00",slug:"positive-and-negative-aspects-of-outsourcing",bookSignature:"Mário Franco",coverURL:"https://cdn.intechopen.com/books/images_new/6180.jpg",editedByType:"Edited by",editors:[{id:"105529",title:"Dr.",name:"Mário",surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4686",title:"Perspectives on Business and Management",subtitle:null,isOpenForSubmission:!1,hash:"39e4396dfbd84c6c0f014bc4b1263110",slug:"perspectives-on-business-and-management",bookSignature:"Vito Bobek",coverURL:"https://cdn.intechopen.com/books/images_new/4686.jpg",editedByType:"Edited by",editors:[{id:"128342",title:"Prof.",name:"Vito",surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1385",title:"Advanced Topics in Applied Operations Management",subtitle:null,isOpenForSubmission:!1,hash:"ef5c00eb107de910b3641016f2c6a1d1",slug:"advanced-topics-in-applied-operations-management",bookSignature:"Yair Holtzman",coverURL:"https://cdn.intechopen.com/books/images_new/1385.jpg",editedByType:"Edited by",editors:[{id:"96791",title:"Mr.",name:"Yair",surname:"Holtzman",slug:"yair-holtzman",fullName:"Yair Holtzman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7570",title:"Strategic Management",subtitle:"a Dynamic View",isOpenForSubmission:!1,hash:"f64ac900c22d892e48ff84a23668f124",slug:"strategic-management-a-dynamic-view",bookSignature:"Okechukwu Lawrence Emeagwali",coverURL:"https://cdn.intechopen.com/books/images_new/7570.jpg",editedByType:"Edited by",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1325",title:"Advances in Customer Relationship Management",subtitle:null,isOpenForSubmission:!1,hash:"c00c0699c09d1a96c619153d82f37eea",slug:"advances-in-customer-relationship-management",bookSignature:"Daniel Catalan-Matamoros",coverURL:"https://cdn.intechopen.com/books/images_new/1325.jpg",editedByType:"Edited by",editors:[{id:"49198",title:"Dr.",name:"Daniel",surname:"Catalan-Matamoros",slug:"daniel-catalan-matamoros",fullName:"Daniel Catalan-Matamoros"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"erratum-covid-19-transmission-in-children-implications-for",title:"Erratum: COVID-19 Transmission in Children: Implications for Schools",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/78823.pdf",downloadPdfUrl:"/chapter/pdf-download/78823",previewPdfUrl:"/chapter/pdf-preview/78823",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/78823",risUrl:"/chapter/ris/78823",chapter:{id:"77986",slug:"covid-19-transmission-in-children-implications-for-schools",signatures:"Evelyn Mendoza-Torres, Franklin Torres, Wendy Rosales-Rada, Liliana Encinales, Lil Avendaño, María Fernanda Pérez, Ivana Terán, David Vergara, Estefanie Osorio-Llanes, Paige Fierbaugh, Wendy Villamizar, Aileen Y. Chang and Jairo Castellar-Lopez",dateSubmitted:"June 15th 2021",dateReviewed:"July 12th 2021",datePrePublished:"September 13th 2021",datePublished:"March 16th 2022",book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"342716",title:"Assistant Prof.",name:"Aileen",middleName:null,surname:"Y. Chang",fullName:"Aileen Y. Chang",slug:"aileen-y.-chang",email:"chang@email.gwu.edu",position:null,institution:null},{id:"342718",title:"Dr.",name:"Evelyn",middleName:null,surname:"Mendoza-Torres",fullName:"Evelyn Mendoza-Torres",slug:"evelyn-mendoza-torres",email:"evelyn.mendozat@unilibre.edu.co",position:null,institution:{name:"Free University of Colombia",institutionURL:null,country:{name:"Colombia"}}},{id:"427633",title:"Dr.",name:"Franklin",middleName:null,surname:"Torres",fullName:"Franklin Torres",slug:"franklin-torres",email:"dummy+427633@intechopen.com",position:null,institution:null},{id:"427634",title:"Dr.",name:"Wendy",middleName:null,surname:"Rosales-Rada",fullName:"Wendy Rosales-Rada",slug:"wendy-rosales-rada",email:"dummy+427634@intechopen.com",position:null,institution:null},{id:"427635",title:"Dr.",name:"Liliana",middleName:null,surname:"Encinales",fullName:"Liliana Encinales",slug:"liliana-encinales",email:"dummy+427635@intechopen.com",position:null,institution:null},{id:"427636",title:"Dr.",name:"Lil",middleName:null,surname:"Avendaño",fullName:"Lil Avendaño",slug:"lil-avendano",email:"dummy+427636@intechopen.com",position:null,institution:null},{id:"427637",title:"Dr.",name:"María Fernanda",middleName:null,surname:"Pérez",fullName:"María Fernanda Pérez",slug:"maria-fernanda-perez",email:"dummy+427637@intechopen.com",position:null,institution:null},{id:"427638",title:"Dr.",name:"Ivana",middleName:null,surname:"Terán",fullName:"Ivana Terán",slug:"ivana-teran",email:"dummy+427638@intechopen.com",position:null,institution:null},{id:"427639",title:"Dr.",name:"David",middleName:null,surname:"Vergara",fullName:"David Vergara",slug:"david-vergara",email:"dummy+427639@intechopen.com",position:null,institution:null},{id:"427640",title:"Dr.",name:"Estefanie",middleName:null,surname:"Osorio-Llanes",fullName:"Estefanie Osorio-Llanes",slug:"estefanie-osorio-llanes",email:"dummy+427640@intechopen.com",position:null,institution:null},{id:"427641",title:"Dr.",name:"Paige",middleName:null,surname:"Fierbaugh",fullName:"Paige Fierbaugh",slug:"paige-fierbaugh",email:"dummy+427641@intechopen.com",position:null,institution:null},{id:"427642",title:"Dr.",name:"Wendy",middleName:null,surname:"Villamizar",fullName:"Wendy Villamizar",slug:"wendy-villamizar",email:"dummy+427642@intechopen.com",position:null,institution:null},{id:"457495",title:"Dr.",name:"Jairo",middleName:null,surname:"Castellar-Lopez",fullName:"Jairo Castellar-Lopez",slug:"jairo-castellar-lopez",email:"dummy+427643@intechopen.com",position:null,institution:null}]}},chapter:{id:"77986",slug:"covid-19-transmission-in-children-implications-for-schools",signatures:"Evelyn Mendoza-Torres, Franklin Torres, Wendy Rosales-Rada, Liliana Encinales, Lil Avendaño, María Fernanda Pérez, Ivana Terán, David Vergara, Estefanie Osorio-Llanes, Paige Fierbaugh, Wendy Villamizar, Aileen Y. Chang and Jairo Castellar-Lopez",dateSubmitted:"June 15th 2021",dateReviewed:"July 12th 2021",datePrePublished:"September 13th 2021",datePublished:"March 16th 2022",book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"342716",title:"Assistant Prof.",name:"Aileen",middleName:null,surname:"Y. Chang",fullName:"Aileen Y. Chang",slug:"aileen-y.-chang",email:"chang@email.gwu.edu",position:null,institution:null},{id:"342718",title:"Dr.",name:"Evelyn",middleName:null,surname:"Mendoza-Torres",fullName:"Evelyn Mendoza-Torres",slug:"evelyn-mendoza-torres",email:"evelyn.mendozat@unilibre.edu.co",position:null,institution:{name:"Free University of Colombia",institutionURL:null,country:{name:"Colombia"}}},{id:"427633",title:"Dr.",name:"Franklin",middleName:null,surname:"Torres",fullName:"Franklin Torres",slug:"franklin-torres",email:"dummy+427633@intechopen.com",position:null,institution:null},{id:"427634",title:"Dr.",name:"Wendy",middleName:null,surname:"Rosales-Rada",fullName:"Wendy Rosales-Rada",slug:"wendy-rosales-rada",email:"dummy+427634@intechopen.com",position:null,institution:null},{id:"427635",title:"Dr.",name:"Liliana",middleName:null,surname:"Encinales",fullName:"Liliana Encinales",slug:"liliana-encinales",email:"dummy+427635@intechopen.com",position:null,institution:null},{id:"427636",title:"Dr.",name:"Lil",middleName:null,surname:"Avendaño",fullName:"Lil Avendaño",slug:"lil-avendano",email:"dummy+427636@intechopen.com",position:null,institution:null},{id:"427637",title:"Dr.",name:"María Fernanda",middleName:null,surname:"Pérez",fullName:"María Fernanda Pérez",slug:"maria-fernanda-perez",email:"dummy+427637@intechopen.com",position:null,institution:null},{id:"427638",title:"Dr.",name:"Ivana",middleName:null,surname:"Terán",fullName:"Ivana Terán",slug:"ivana-teran",email:"dummy+427638@intechopen.com",position:null,institution:null},{id:"427639",title:"Dr.",name:"David",middleName:null,surname:"Vergara",fullName:"David Vergara",slug:"david-vergara",email:"dummy+427639@intechopen.com",position:null,institution:null},{id:"427640",title:"Dr.",name:"Estefanie",middleName:null,surname:"Osorio-Llanes",fullName:"Estefanie Osorio-Llanes",slug:"estefanie-osorio-llanes",email:"dummy+427640@intechopen.com",position:null,institution:null},{id:"427641",title:"Dr.",name:"Paige",middleName:null,surname:"Fierbaugh",fullName:"Paige Fierbaugh",slug:"paige-fierbaugh",email:"dummy+427641@intechopen.com",position:null,institution:null},{id:"427642",title:"Dr.",name:"Wendy",middleName:null,surname:"Villamizar",fullName:"Wendy Villamizar",slug:"wendy-villamizar",email:"dummy+427642@intechopen.com",position:null,institution:null},{id:"457495",title:"Dr.",name:"Jairo",middleName:null,surname:"Castellar-Lopez",fullName:"Jairo Castellar-Lopez",slug:"jairo-castellar-lopez",email:"dummy+427643@intechopen.com",position:null,institution:null}]},book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"8250",leadTitle:null,title:"The Burden of Respiratory Syncytial Virus Infection in the Young",subtitle:null,reviewType:"peer-reviewed",abstract:"Respiratory syncytial virus (RSV) causes seasonal epidemics during the winter and wet seasons, particularly in young children. Although there is one drug available for prophylaxis, palivizumab, it is indicated for high-risk children only. Therefore a vaccine is urgently needed. This book provides an overview of RSV and discusses its incidence and presentation in different populations, including preterm infants and children with congenital heart disease. It also discusses future strategies for RSV prophylaxis and developments in and barriers to creating a viable vaccine.",isbn:"978-1-78984-643-0",printIsbn:"978-1-78984-642-3",pdfIsbn:"978-1-83962-252-6",doi:"10.5772/intechopen.78206",price:119,priceEur:129,priceUsd:155,slug:"the-burden-of-respiratory-syncytial-virus-infection-in-the-young",numberOfPages:108,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"576eea34382b48ecff475d3f267837a2",bookSignature:"Bernhard Resch",publishedDate:"October 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8250.jpg",keywords:null,numberOfDownloads:4820,numberOfWosCitations:6,numberOfCrossrefCitations:5,numberOfDimensionsCitations:10,numberOfTotalCitations:21,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 6th 2018",dateEndSecondStepPublish:"January 14th 2019",dateEndThirdStepPublish:"March 15th 2019",dateEndFourthStepPublish:"May 20th 2019",dateEndFifthStepPublish:"July 19th 2019",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"66173",title:"Prof.",name:"Bernhard",middleName:null,surname:"Resch",slug:"bernhard-resch",fullName:"Bernhard Resch",profilePictureURL:"https://mts.intechopen.com/storage/users/66173/images/system/66173.png",biography:"Born in Graz, Austria, Prof. Resch received his medical degree at the Karl-Franzens-University Graz in 1988. Following post-doc studies at the Division of Neonatology, and the Department of Pediatric Surgery of the University Hospital Graz, he became consultant of Pediatrics in 1997 and consultant of Neonatal and Pediatric Intensive Care Medicine in 2000. Since 2004, he is Professor of Pediatrics and since 2008, Head of the Research Unit of Neonatal Infectious Diseases and Epidemiology of the Medical University Graz. Since 2012 he is Deputy Head of the Division of Neonatology of the Medical University of Graz. His main research fields include neonatal infectious diseases, RSV infection, periventricular leukomalacia of the preterm infant, the neonatal microbiome and the role of probiotics.\nHe is a member and board member of several scientific societies including ESPID, past president of the Austrian Society of Perinatal Medicine, and member of the editorial board of several international journals including 'BMC Infectious Diseases' and 'Frontiers in Pediatrics'",institutionString:"Medical University of Graz",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Medical University of Graz",institutionURL:null,country:{name:"Austria"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1047",title:"Pulmonology",slug:"pulmonology"}],chapters:[{id:"68674",title:"Disease Severity in Respiratory Syncytial Virus Infection: Role of Viral and Host Factors",slug:"disease-severity-in-respiratory-syncytial-virus-infection-role-of-viral-and-host-factors",totalDownloads:772,totalCrossrefCites:0,authors:[{id:"290959",title:"Dr.",name:"Julian",surname:"Legg",slug:"julian-legg",fullName:"Julian Legg"},{id:"409527",title:"Dr.",name:"Julian P.",surname:"Legg",slug:"julian-p.-legg",fullName:"Julian P. Legg"}]},{id:"66054",title:"Resolving the Debate on RSV Prophylaxis in Late Preterm Infants",slug:"resolving-the-debate-on-rsv-prophylaxis-in-late-preterm-infants",totalDownloads:819,totalCrossrefCites:0,authors:[{id:"287108",title:"Dr.",name:"Barry",surname:"Rodgers-Gray",slug:"barry-rodgers-gray",fullName:"Barry Rodgers-Gray"},{id:"287110",title:"Dr.",name:"Bosco",surname:"Paes",slug:"bosco-paes",fullName:"Bosco Paes"},{id:"287130",title:"Prof.",name:"Xavier",surname:"Carbonell-Estrany",slug:"xavier-carbonell-estrany",fullName:"Xavier Carbonell-Estrany"},{id:"406705",title:"Dr.",name:"Bosco",surname:"Paes",slug:"bosco-paes",fullName:"Bosco Paes"},{id:"406706",title:"Dr.",name:"Barry",surname:"Rodgers-Gray",slug:"barry-rodgers-gray",fullName:"Barry Rodgers-Gray"},{id:"406707",title:"Dr.",name:"Xavier",surname:"Carbonell-Estrany",slug:"xavier-carbonell-estrany",fullName:"Xavier Carbonell-Estrany"}]},{id:"66450",title:"Respiratory Syncytial Virus Infections among Children with Congenital Heart Disease",slug:"respiratory-syncytial-virus-infections-among-children-with-congenital-heart-disease",totalDownloads:997,totalCrossrefCites:1,authors:[{id:"288835",title:"Dr.",name:"Maja",surname:"Daurach",slug:"maja-daurach",fullName:"Maja Daurach"},{id:"407393",title:"Dr.",name:"Maja",surname:"Daurach",slug:"maja-daurach",fullName:"Maja Daurach"},{id:"407394",title:"Dr.",name:"Ina",surname:"Michel-Behnke",slug:"ina-michel-behnke",fullName:"Ina Michel-Behnke"}]},{id:"65931",title:"RSV: Available Prophylactic Options and Vaccines in Clinical Trials",slug:"rsv-available-prophylactic-options-and-vaccines-in-clinical-trials",totalDownloads:1020,totalCrossrefCites:2,authors:[{id:"287189",title:"Dr.",name:"Fariba",surname:"Rezaee",slug:"fariba-rezaee",fullName:"Fariba Rezaee"},{id:"287519",title:"BSc.",name:"Debra",surname:"Linfield",slug:"debra-linfield",fullName:"Debra Linfield"},{id:"406495",title:"Dr.",name:"Debra T.",surname:"Linfield",slug:"debra-t.-linfield",fullName:"Debra T. Linfield"},{id:"406496",title:"Dr.",name:"Fariba",surname:"Rezaee",slug:"fariba-rezaee",fullName:"Fariba Rezaee"}]},{id:"68404",title:"Hurdles in Vaccine Development against Respiratory Syncytial Virus",slug:"hurdles-in-vaccine-development-against-respiratory-syncytial-virus",totalDownloads:1221,totalCrossrefCites:2,authors:[{id:"201590",title:"Dr.",name:"Bilal",surname:"Aslam",slug:"bilal-aslam",fullName:"Bilal Aslam"},{id:"224512",title:"Dr.",name:"Muhammad Asif",surname:"Zahoor",slug:"muhammad-asif-zahoor",fullName:"Muhammad Asif Zahoor"},{id:"229168",title:"Dr.",name:"Abu Baker",surname:"Siddique",slug:"abu-baker-siddique",fullName:"Abu Baker Siddique"},{id:"229169",title:"Dr.",name:"Muhammad",surname:"Shafique",slug:"muhammad-shafique",fullName:"Muhammad Shafique"},{id:"261133",title:"Dr.",name:"Muhammad Hidayat",surname:"Rasool",slug:"muhammad-hidayat-rasool",fullName:"Muhammad Hidayat Rasool"},{id:"288062",title:"Dr.",name:"Muhammad Imran",surname:"Arshad",slug:"muhammad-imran-arshad",fullName:"Muhammad Imran Arshad"},{id:"303654",title:"Dr.",name:"Muhammad Usman",surname:"Qamar",slug:"muhammad-usman-qamar",fullName:"Muhammad Usman Qamar"},{id:"303655",title:"Mr.",name:"Muhammad",surname:"Usman",slug:"muhammad-usman",fullName:"Muhammad Usman"},{id:"409438",title:"Dr.",name:"Muhammad",surname:"Shafique",slug:"muhammad-shafique",fullName:"Muhammad Shafique"},{id:"409439",title:"Dr.",name:"Muhammad Asif",surname:"Zahoor",slug:"muhammad-asif-zahoor",fullName:"Muhammad Asif Zahoor"},{id:"409440",title:"Dr.",name:"Muhammad Imran",surname:"Arshad",slug:"muhammad-imran-arshad",fullName:"Muhammad Imran Arshad"},{id:"409441",title:"Dr.",name:"Bilal",surname:"Aslam",slug:"bilal-aslam",fullName:"Bilal Aslam"},{id:"409442",title:"Dr.",name:"Abu Baker",surname:"Siddique",slug:"abu-baker-siddique",fullName:"Abu Baker Siddique"},{id:"409443",title:"Dr.",name:"Muhammad Hidayat",surname:"Rasool",slug:"muhammad-hidayat-rasool",fullName:"Muhammad Hidayat Rasool"},{id:"409444",title:"Dr.",name:"Muhammad Usman",surname:"Qamar",slug:"muhammad-usman-qamar",fullName:"Muhammad Usman Qamar"},{id:"409445",title:"Dr.",name:"Muhammad",surname:"Usman",slug:"muhammad-usman",fullName:"Muhammad Usman"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"194666",firstName:"Nina",lastName:"Kalinic Babic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/194666/images/4750_n.jpg",email:"nina@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"990",title:"Human Respiratory Syncytial Virus Infection",subtitle:null,isOpenForSubmission:!1,hash:"b5d980a120eec6669c7f37a5082f0696",slug:"human-respiratory-syncytial-virus-infection",bookSignature:"Bernhard Resch",coverURL:"https://cdn.intechopen.com/books/images_new/990.jpg",editedByType:"Edited by",editors:[{id:"66173",title:"Prof.",name:"Bernhard",surname:"Resch",slug:"bernhard-resch",fullName:"Bernhard Resch"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2990",title:"Neonatal Bacterial Infection",subtitle:null,isOpenForSubmission:!1,hash:"093e4b7e0964b0fe0229a4b4cafef28c",slug:"neonatal-bacterial-infection",bookSignature:"Bernhard Resch",coverURL:"https://cdn.intechopen.com/books/images_new/2990.jpg",editedByType:"Edited by",editors:[{id:"66173",title:"Prof.",name:"Bernhard",surname:"Resch",slug:"bernhard-resch",fullName:"Bernhard Resch"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"956",title:"Cystic Fibrosis",subtitle:"Renewed Hopes Through Research",isOpenForSubmission:!1,hash:"703f0969078948d82535b7b0c08ab613",slug:"cystic-fibrosis-renewed-hopes-through-research",bookSignature:"Dinesh Sriramulu",coverURL:"https://cdn.intechopen.com/books/images_new/956.jpg",editedByType:"Edited by",editors:[{id:"91317",title:"Dr.",name:"Dinesh",surname:"Sriramulu",slug:"dinesh-sriramulu",fullName:"Dinesh Sriramulu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"969",title:"Lung Diseases",subtitle:"Selected State of the Art Reviews",isOpenForSubmission:!1,hash:"b4344208b8b993d83e0131d23db46343",slug:"lung-diseases-selected-state-of-the-art-reviews",bookSignature:"Elvis Malcolm Irusen",coverURL:"https://cdn.intechopen.com/books/images_new/969.jpg",editedByType:"Edited by",editors:[{id:"87213",title:"Prof.",name:"Elvis",surname:"Irusen",slug:"elvis-irusen",fullName:"Elvis Irusen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"648",title:"Chronic Obstructive Pulmonary Disease",subtitle:"Current Concepts and Practice",isOpenForSubmission:!1,hash:"d52ddc19c473a70b91e5a64f41760a04",slug:"chronic-obstructive-pulmonary-disease-current-concepts-and-practice",bookSignature:"Kian-Chung Ong",coverURL:"https://cdn.intechopen.com/books/images_new/648.jpg",editedByType:"Edited by",editors:[{id:"103585",title:"Dr.",name:"Kian Chung",surname:"Ong",slug:"kian-chung-ong",fullName:"Kian Chung Ong"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5444",title:"Hypoxia and Human Diseases",subtitle:null,isOpenForSubmission:!1,hash:"331b1aa8d399bc404988a8bc5e431582",slug:"hypoxia-and-human-diseases",bookSignature:"Jing Zheng and Chi Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/5444.jpg",editedByType:"Edited by",editors:[{id:"89898",title:"Dr.",name:"Jing",surname:"Zheng",slug:"jing-zheng",fullName:"Jing Zheng"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3843",title:"Lung Inflammation",subtitle:null,isOpenForSubmission:!1,hash:"92938e8752fa3444849d88b776cd7892",slug:"lung-inflammation",bookSignature:"Kian Chung Ong",coverURL:"https://cdn.intechopen.com/books/images_new/3843.jpg",editedByType:"Edited by",editors:[{id:"103585",title:"Dr.",name:"Kian Chung",surname:"Ong",slug:"kian-chung-ong",fullName:"Kian Chung Ong"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3309",title:"Respiratory Disease and Infection",subtitle:"A New Insight",isOpenForSubmission:!1,hash:"2e85d47bf0576f1c2ccf642156ccbda2",slug:"respiratory-disease-and-infection-a-new-insight",bookSignature:"Bassam H. Mahboub",coverURL:"https://cdn.intechopen.com/books/images_new/3309.jpg",editedByType:"Edited by",editors:[{id:"148941",title:"Dr.",name:"Mayank",surname:"Vats",slug:"mayank-vats",fullName:"Mayank Vats"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"989",title:"Respiratory Diseases",subtitle:null,isOpenForSubmission:!1,hash:"d4856a618f9ca898b76edc356ad3067b",slug:"respiratory-diseases",bookSignature:"Mostafa Ghanei",coverURL:"https://cdn.intechopen.com/books/images_new/989.jpg",editedByType:"Edited by",editors:[{id:"90900",title:"Dr.",name:"Mostafa",surname:"Ghanei",slug:"mostafa-ghanei",fullName:"Mostafa Ghanei"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"783",title:"Pulmonary Hypertension",subtitle:"From Bench Research to Clinical Challenges",isOpenForSubmission:!1,hash:"488ca2b21e4374b6337d1aacbd107c3b",slug:"pulmonary-hypertension-from-bench-research-to-clinical-challenges",bookSignature:"Roxana Sulica and Ioana Preston",coverURL:"https://cdn.intechopen.com/books/images_new/783.jpg",editedByType:"Edited by",editors:[{id:"74136",title:"Dr.",name:"Roxana",surname:"Sulica",slug:"roxana-sulica",fullName:"Roxana Sulica"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"68628",title:"The Health and Economic Costs of Violence against Women and Girls on Survivors, Their Families, and Communities in Ghana",doi:"10.5772/intechopen.88690",slug:"the-health-and-economic-costs-of-violence-against-women-and-girls-on-survivors-their-families-and-co",body:'
1. Introduction
Violence against women and girls (VAWG) is a critical public health, societal, and economic problem affecting 35% of women globally [1]. Women from all countries, socio-economic status, culture and religion can be affected by violence perpetrated by spouses, other family members, authority figures, work colleagues, acquaintances and strangers. The impacts of such violence are widespread and long lasting, ranging from physical injuries, to functional disorders, to reduced capabilities [1]. Countries in the continent of Africa are not exempt from such experiences. In this chapter we focus on evidence of the impacts of VAWG in Ghana.
Ghana is a middle income country that has made progress in improving the status of women, currently ranking 59th out of 144 countries in the Global Gender Gap Index and 11th in Africa [2]. Nevertheless, VAWG has persisted as a problem affecting approximately one third of women during their lifetime [3, 4]. While there are a wide range of forms of violence that women in Ghana may experience, the most common form of violence reported across multiple studies, is intimate partner violence (IPV). Other forms of violence reported in Ghana include sexual violence by non-partners, violence by other family members, sexual harassment, forced and early marriage, female genital mutilation and other forms of harmful cultural practices [5, 6, 7].
Increasing the political will to invest in the prevention of VAWG is an ongoing task that many organisations in Ghana are undertaking. We aim to contribute to such efforts by providing evidence that VAWG affects the health and well-being of those who experience it directly, as well as their families and communities, creating costs that undermine personal capacity, family and community stability, and ultimately the economy as a whole. In this study, we focus on IPV, as well as violence against women by other family members in the home, violence in the workplace, educational institute and/or public space and consider the impact of physical, sexual, economic and psychological violence.
Our study examines the economic losses caused by VAWG and the non-economic costs of violence that impact economic growth, development, and social stability. The project was supported by the UK Department for International Development (DFID) in recognition of the dearth of knowledge on the social and economic costs of VAWG. The study presented in this chapter is part of a larger project that the National University of Ireland, Galway with Ipsos-MORI and International Centre for Research on Women (ICRW), in collaboration with in-country partners, conducted in Ghana, Pakistan and South Sudan to estimate the economic losses caused by VAWG.
In this chapter we present evidence of the costs of violence as they impact on the health and wellbeing of women who experience violence in Ghana. We further consider the ‘costs’ to households and communities. Finally, we extrapolate some of these costs to the national level to consider how VAWG impacts the economy of Ghana. Importantly, these findings represent only a small proportion of the overall cost of VAWG, based on costs captured in the study that are tangible and quantifiable. The overall loss to Ghanaian society and economy due to VAWG is certain to be far higher than can be presented here.
2. Literature/state of knowledge
The literature about VAWG in Ghana provides a plethora of evidence about the depth and prevalence of the problem. The 2008 Ghana Demographic and Health Survey (GDHS) suggests that at least one out of every three ever-married women experienced some form of sexual, physical, and/or emotional violence from a husband or partner in their lifetime [3]. Similar findings were also identified in the recent Ghana Family Life and Health Survey (GFLHS) [4]. Here, the study found that 28% of women reported experiencing IPV (including physical, sexual, economic, social, and/or psychological violence) in the past 12 months. The study also highlighted the impact on daily life and wellbeing of survivors of IPV and their families [4].
Feminist contributions to understanding VAWG have identified that unequal gender power relations that are characteristic of patriarchy influence the forms and prevalence of VAWG in Ghana [5], as elsewhere on the African Continent [8], and globally [9]. Heise’s ecological framework further develops the theory in relation to the aetiology of VAWG through recognition of the complex interplay between personal, situational and socio-cultural factors [10]. These contributions clearly situate the drivers of VAWG within social experiences, and thus importantly shift away from explanations of violence that are purely psychological (e.g. as a personality defect) or due to simplistic cause and effect (e.g. the woman burned the dinner so the man beat her). Such understandings have allowed the emergence of a wide-range of interventions and programmes targeted at ending, reducing or mitigating VAWG [11]; however, investment and uptake of these remains limited, in part due to failure to fully grasp the impacts of violence on economic stability, growth and development. Heise’s application of the social and ecological framework to explain VAWG has been adopted internationally as a theoretical framework that calls attention to the interplay of factors at multiple levels, the individual, the household, the community and society as a whole. Our study uses this framework to discuss the impacts of VAWG at different societal levels as well [10].
A number of studies have demonstrated the pervasive effects of violence on the health of survivors. In 2016, in Ghana, a mixed methods nationally representative study found that 44% of women who had experienced domestic physical violence in the previous 12 months had been ill in the 30 days prior to the survey, compared to 31% of women who had not experienced this type of domestic violence [4]. In studies in northern Ghana, women reported feelings of worthlessness, suicidal ideation, hypertension, sleep disruption, genital sores, and premature termination of pregnancy as a result of the violence they experienced [12, 13]. The GFLHS study also identified strong correlations between exposure to IPV and serious mental illness. Relationships were further identified between IPV, health impacts and quality of life, with violence affecting women’s ability to go to work, to school, complete domestic chores, and concentrate on activities as well as reducing their level of confidence [4].
In addition to physical and mental health impacts and their sequelae, a number of studies in Ghana have outlined pathways through which VAWG impacts individuals and households in Ghana. For instance, Essel finds evidence of women being prevented from working by intimate partners or who have their earnings taken by them [14]. Cantalupo et al. and Danso document costs to victims of VAWG, such as fees for doctors, that result in losses to household income [15, 16]. The children of women were also found to be affected by their mothers’ experience of violence, including impacts on behaviour and education that results in long-term opportunity costs [4]. However, there is a dearth of studies that aim to assess the costs of violence beyond the individual or household, resulting in a fragmented understanding of the true impact of VAWG in Ghana.
Despite the high prevalence, there is still a gap between needs and service provision to women and girls who have experienced VAWG. The government of Ghana is a signatory of international treaties that convey a framework for actions to prevent and combat VAWG [17]. Ghana has a Domestic Violence Act, which aims to protect domestic violence victims [18], and approved a National Gender Policy in 2015 [19]. Its main instrument at the local level, the Domestic Violence Victims Services Unit (DOVVSU), has a key role in implementing the law and policy on GBV in Ghana despite having only nearly 180 inadequately resourced units [17]. Advocating for adequate investment in programmes aimed at reducing the prevalence of VAWG or mitigating the impact of VAWG, in line with Government obligations, is facilitated by adequate information about the costs of violence.
Understanding the broad range of impacts of VAWG is still a key gap in the literature. Such evidence is particularly compelling to incentivise government investments in programmes and services for survivors. Identifying and quantifying, where possible, the costs of violence is thus an important contribution towards understanding and addressing VAWG in Ghana.
3. Methodology
This chapter discusses the impacts of VAWG and its health, social and economic effects on the families and communities of the survivors. We argue that the impact of VAWG goes beyond individual health effects. VAWG affects individual women and girls, their families, their communities and larger societal and economic structures (See Figure 1 for the conceptual framework of the study). Using this framework, this study measures the impact of intimate partner violence (IPV) and sexual violence by non-intimate partner (NPSV) on the health and wellbeing of the women and girls who experience violence. It also estimates the social and economic costs of VAWG by analysing the direct and indirect tangible and intangible costs by looking at the impact on both the individual and society.
Figure 1.
Conceptual framework of social and economic impacts of VAWG and economic loss.
For this, a mixed method study consisting of both quantitative surveys with women and with households and qualitative interviews was implemented. For the quantitative study, the team used a household questionnaire to collect data about the general household and individuals within the household and a women’s questionnaire applied only to women between 18 and 60 years of age. A multidisciplinary team surveyed 2002 women and 1917 households in 10 regions in Ghana.
The surveyors requested consent to a follow up qualitative interview to all participants in the women’s survey. The team selected women and men to participate in in-depth interviews (IDIs), key informant interviews (KIIs) and focus group discussions (FGDs) conducted in Ga and Twi. The team conducted 28 IDIs and 8 FGDs with between 6 and 10 women and men and 10 KIIs (Table 1).
Urban areas
Rural areas
Total
Quantitative survey (female)
1046
956
2002
In-depth interviews (female)
15
13
28
Focus group discussions (male, 6–10 participants in each group)
15
13
28
Focus group discussions (female, 6–10 participants in each group)
16
19
35
Key informant interviews (female/male)
5
5
10
Table 1.
Number of participants by type of data collection activity.
Researchers used Stata and/or SPSS for the quantitative analysis and NVivo to analyse qualitative data. During the analysis, the team created quality of life measures to establish health effects of IPV on the woman involved, her partner and her children. The authors used econometric modelling to establish implications, including economic, social and health, of experiences of violence. The analysis included violence at the household level and at the workplace, educational institutes and in public spaces. At the household level, the analysis included the type and nature of injuries suffered, and the impact of IPV on reproductive, physical and mental health.
4. Findings and discussion
The study found, in-line with previous studies, that violence is a common experience for women in Ghana. An estimated 46% of the respondents of the women’s survey reported having experienced physical, psychological, sexual or economic violence in the home, workplace, educational institution, or public space in the past 12 months. In the case of IPV, 43% of partnered women had suffered IPV in the last 12 months.
Incidents of violence ranged in severity. In relation to IPV, the study found that 38% of IPV survivors reported suffering severe violence. This means that they experienced economic or psychological violence in a frequency greater than 10 times, physical violence greater than three times and/or sexual violence during the last 12 months. Twenty-five percent of women reported moderate violence, defined as physical violence once or twice and economic and psychological violence 6–10 times. Finally 36% reported low violence, defined as economic or psychological violence up to five times in past 12 months.
Additionally, women reported VAWG in a range of locations, and violence by different types of perpetrators, not just their partners or relatives. About 4% of the total sample in this study reported experiencing violence in educational institutions. About 18% of female respondents reported having suffered some form of violence in a public space, such as the market, on public transportation or on streets. About 43% of female respondents who are married or have a partner and 47% of female respondents who are staying with other family members reported IPV and violence by other family members respectively. Twenty four percent of female respondents who were working reported workplace violence.
The evidence indicates that women in Ghana experience violence from a range of actors and locations. Notably, while violence occurs in workplaces, public spaces and in educational institutes, the home was identified as the place women are most likely to experience violence. The impact of these incidents of violence, on both physical and psychological well-being and on women’s capabilities is critical to assess to gain a deeper understanding of the scope and depth of the problem of VAWG in Ghana.
4.1 Impacts on women’s health, well-being, and capabilities
Impacts of VAWG can occur in a myriad of ways, often indirect, hence difficult to fully capture in a single study. However, the negative impact of VAWG on the health and well-being of survivors is clear. As is explored below, these impacts often have far-reaching consequences that go beyond the immediate injuries (whether physical or psychological) to constrain women’s capabilities in relation to a number of functions, including working, learning, and socialising.
4.1.1 Physical, mental health, and reproductive impacts of IPV
In line with the literature, participants in this survey and qualitative study identified a number of different negative impacts due to VAWG. These included physical, reproductive, and mental health impacts, discussed further below.
Many participants highlighted physical injuries, chronic pain, and disability as a result of beating, hitting, slapping, or other physically violent acts. Drawing from data from the women’s survey, a set of scores were constructed, including disability, illness, and depression scores, to identify the strength and significance of the relationship between these health outcomes and experience of IPV, the most commonly experienced form of VAWG in the study. The disability score was calculated based on the following elements: visual, auditory, mobility, cognitive, and articulation difficulties. The score was computed by summing up the level of difficulty of these elements as experienced by respondents. There was a weak but statistically significant relationship between experience of physical and/or sexual IPV and higher disability score.
Similarly, an acute illness score was constructed that identified particularly strong relationships between higher scores on the scale and experience of any form of IPV. The acute illness score was calculated based on: acute health problem, acute impairment, acute pain, consulting any health care worker, headache, loss of appetite, poor sleep, anxiety, difficulty in thinking clearly, mood, crying, loss of enjoyment, difficulty in making decisions, loss of productivity, loss of interest, worthlessness, and tiredness in past 4 weeks. The acute illness score was statistically significantly higher among women who experienced any of the forms of IPV considered (P-value <0.001).
Participants reported insomnia, feelings of anxiety, and varying degrees of depression. Women reported chronic fear after being raped; that fear was described as turning into intense and persistent worry that some women said “could lead one to lose [their] sanity”. A depression score, calculated based on suicidal thoughts, loss of interest, mood, poor sleep, tiredness, loss of appetite, worthlessness, and difficulty in thinking clearly, found that women who had experienced any form of IPV scored statistically significantly higher than women who had not experienced IPV (P value <0.001) (Table 2).
Economic
Psychological
Physical
Sexual
Yes
No
Yes
No
Yes
No
Yes
No
Disability score
Mean
0.52
0.43
0.49
0.44
0.65
0.41
0.77
0.43
Mean difference
0.09
0.05
0.24
0.34
95% CI
0.366; 0.682
0.344; 0.518
0.359; 0.614
0.343; 0.534
0.445; 0.845
0.324; 0.486
0.440; 1.094
0.348; 0.503
P value
0.293
0.554
0.012
0.011
Acute illness score
Mean
11.31
8.29
11.19
8.09
11.43
8.57
14.16
8.66
Mean difference
3.02
3.1
2.86
5.50
95% CI
10.539; 12.081
7.746; 8.835
10.460; 11.914
7.536; 8.643
10.550; 12.308
8.040; 9.097
12.989; 15.331
8.195; 9.119
P value
0.000
0.000
0.000
0.000
Depression score
Mean
3.2
1.6
2.8
1.6
3.02
1.71
3.98
1.78
Mean difference
1.6
1.2
1.31
2.20
95% CI
2.928; 3.495
1.415; 1.689
2.515; 3.013
1.423; 1.715
2.670; 3.361
1.575; 1.847
3.404; 4.561
1.652; 1.908
P value
0.000
0.000
0.000
0.000
Table 2.
Physical and mental health outcome scores among partnered women in past 12 months [20].
Out of the total sample of 2002 women, about 52% of women who had experienced health problems in the last 4 weeks also reported experiencing IPV in the last 12 months. Nineteen percent of women who experienced IPV reported having had suicidal thoughts. Out of this number, 63% attempted suicide.
The survey data was used to identify sexual and reproductive health impacts of physical and sexual violence (PSV). The proportion of women who had miscarried and had suffered PSV (15%) is higher than the proportion of women who have miscarried and have not suffered PSV (14%). We did not find significant differences between women who had suffered PSV and those who had not suffered PSV in terms of abortions and still births.
IDI and FGD participants discussed the link between physical violence and sexual abuse and miscarriages and bleeding, and some mentioned contracting infectious diseases such as HIV and other STIs. Many participants linked VAWG experiences to fatal consequences indirectly as they discussed that depression could lead to suicide or fatal complications of unsafe abortions. Respondents discussed several instances of women who died, or were severely ill, from injuries suffered as a result of VAWG or unsafe abortions.
Notably, some participants also distinguished between acceptable and unacceptable levels of physical violence, based on the degree of harm to the victim, as explained by a participant below:
“…There are different kinds of beating; there is love beating and a beating which can lead to death. There are times your husband will beat, but that is love beating… This small one will not hurt you [reference to love beating]. Wicked beating can lead to death…” - Urban In-Depth Interview, Female
4.1.2 Impacts on capabilities due to VAWG
The mental and physical health effects of VAWG can have secondary affects that impact on women’s capabilities. Participants described how violence could impact women’s mobility, as well as cause them to miss work and school due to physical injuries or psychological distress. VAWG can also create barriers to women’s social and political participation as well as economic agency. Rural participants discussed feelings of shame, fear, and embarrassment associated with having experienced VAWG that kept them from going out in their community to do chores or do attend social events. Participants also discussed remaining at home out of fear of encountering their perpetrator(s) while out in public.
“…She will not be able to go there [market]. She will fear that the man will show up over there to disgrace her. It is a market where a lot of people are found. If he shows up over there, the woman will feel bad so she will not go there, so that she will save herself of the disgrace. If she wants something from the market, she will send someone…” - Rural In-Depth Interview, Female
Women also reported missing work and being unable to conduct other daily activities given the physical and mental health effects, social stigma and reduced mobility that may result of experiencing VAWG. The women’s survey asked respondents about missed work and schooling due to VAWG. The results show that about 6% of women experiencing IPV missed on an average 11 days of work from their economic activity in the prior 12 months. Approximately 4% of women experiencing another form of violence reported missing about 10 days of work in the 12 months. About 8% of women living with school going children reported children missing about 3 days annually due to IPV.
The withdrawal from social and work spaces due to VAWG places a constraint on women’s capabilities that may translate over time to reduced social status and position, isolation and further vulnerabilities. Missed work is likely to result in lost wages and carries with it a significant opportunity cost. These impacts further expose women to poverty, itself a risk-factor for violence. Thus, VAWG significantly undermines women’s potential—an impact that may be passed on to other family members and the next generation.
4.2 Impacts to households
Individual women survivors of VAWG are not the only ones affected by the experience of violence. Family members, including children, are also likely to suffer a range of costs due to VAWG. Below, we discuss the findings of the impacts of VAWG on the health and finances of the relatives of survivors and the impact on the children of survivors.
4.2.1 Health effects on the relatives of survivors
Participants identified several mental health effects of VAWG on relatives of survivors. Among these effects, they discussed depression and feelings of guilt. They also discussed anxiety caused by threats from the perpetrator, social stigma and isolation. This anxiety may affect direct victims but also their relatives, including parents or children of the women and girls affected by VAWG. Further, participants in the qualitative research described that victims of VAWG whose capacity to carry out chores and household duties was reduced, relied on family members for assistance. The time-burden of taking on such extra workloads by the relatives of survivors also contributes to a loss to households.
4.2.2 Economic costs
Families may experience increased expenses and/or loss of income or productivity due to VAWG. The lack of shelters and public support for VAWG survivors create financial hardship that may lead to household dissolution or homelessness in extreme cases. Some participants emphasised that these financial burdens fall onto the woman’s family because there is a lack of formal social support for affected women and their families. Women described economic worries and concerns about their ability to take care of their children as a barrier to escaping VAWG. Families are burdened by hospital bills when survivors require medical care for physical injuries, pregnancies, STIs, or mental health care as a result of VAWG, in addition to the cost of caring for children of women who are no longer able to care for their children due to death or long-term injury.
The study also identified out of pocket expenditures incurred on health care, police, court, shelter and replacing property. For example, a participant described:
“…I was speaking to a woman about this yesterday, and she said when her husband gets angry at her, he just destroys things that belong to her…when she came back he had disconnected the light and spoilt her kettle…” - Rural In-Depth Interview, Female
To estimate these economic costs to households of VAWG an accounting methodology was employed whereby costs were calculated for specific categories and added to calculate the total cost to households and/or society [21]. Tangible costs can be grouped into direct, from the use of goods and services and indirect, calculated using imputed monetary value such as lost income and reduced profits [22]. This approach was used to estimate the costs to households due to VAWG.
The calculations based on the accounting methodology described above were applied to the survey data. It was found that, on average, almost 11% of women experiencing IPV incurred costs of GH¢275.62 due to IPV. Among women experiencing any form of violence, 11% of women reported out of pocket expenditures equivalent to US$53 in the last 12 months, including on health-related expenditures, filing police reports, or replacement of furniture; this amount is equivalent to 10% of the annual per capita expenditure on non-food consumption in Ghana. This economic loss to households has the potential to result in further vulnerability, including poverty, or to the re-direction of funds away from long-term planning, such as children’s education or building a business, towards immediate survival.
4.2.3 Impacts on the children of survivors
IPV does not only affect the victims’ physical and psychological health and social wellbeing, but also the children in the home. Participants discussed direct effects on children, such as fear, anxiety, stigma, and pain; they also discussed how VAWG can lead to the loss of school days when homes are dissolved as a result of violence.
Evidence from the women’s survey provides further support that children are negatively affected by the violence experienced by their mothers. Twenty-one percent of participants in the survey noted that their children felt scared after witnessing IPV. About 18% of them said their children felt confused and 14% reported that their children asked a lot of questions about the incident. An important finding was the children of women who experienced violence were more likely to miss school, due to their mother’s being unable to bring them, or having to help care for their mothers after an incident. It was found that 3 days of school were lost on average per year, among those women with children who reported violence and responded to the question. When extrapolated to the national level, this indicates that nearly 300,000 school days are lost to children in Ghana annually—a significant drain on future potential.
Participants and key informants mentioned that VAWG may become normalised among children who witness it in the household. They were especially concerned about how witnessing violence could lead to male children perpetuating violence in the future and female children accepting violence as a normal part of relationships. While this intangible impact cannot be immediately monetized, the long-term cost to society would be immense and would ultimately translate into economic costs.
It is clear that the cost VAWG is not only an issue for the survivor. It has impacts that ripple beyond the individual to their children and other relatives. Indeed, as is explored below, they also affect whole communities.
4.3 Impacts to community and participation
4.3.1 Help-seeking behaviour and service usage
Studies suggest that the rate of help seeking for VAWG, and IPV in particular, is generally low. Stigma, fear and challenges in availability and access all create barriers to help-seeking. Our survey shows that only 3% of survivors of IPV reported any of the incidents to the police.
Among those who did seek help, participants mentioned seeking help from the Department of Social Welfare, police, and assemblymen as a source of legal aid and punishment for perpetrators; others sought help from local chiefs, traditional community elders, family elders, and religious leaders. However, many participants reported that women were unlikely to seek formal help, such as from police or legal institutions, preferring to seek advice from community or church elders, family members, or close friends, or to keep the issue secret. Reasons for this included normalisation (“this is just how marriage is”), that IPV is a personal issue, and love for their partners. One participant went further, to say that women who did report their husbands would be disparaged by the community:
“People insulted the woman that she was stupid and a foolish. How could she report a man who was the father of her children? Why did she not forgive the man for the sake of her children?” - Rural In-Depth Interview, Female
The evidence suggests that family unity and even community cohesion were deemed as more important than individual wellbeing. Thus, reporting violence was seen as either a failure of the woman to maintain a peaceful household or a selfish act that sacrificed her family’s reputation or wellbeing for her own interests. In such contexts, reporting of IPV is unlikely to occur, potentially reinforcing existing stigma against women who experience violence.
4.3.2 Women’s participation in the community and leadership
Respondents discussed how experiencing VAWG impacted women’s participation in community events and decision-making. They explained that a leader who experiences any type of VAWG would no longer be seen as having “the qualities of a leader” or as being “qualified” to give her opinion on issues in the community, as she would no longer be deemed a good role model. This affects the ability of survivors to take and keep leadership positions in their community. In communities where VAWG is common, the fear of experiencing violence may have an effect on women’s and girls’ mobility and leadership undermining their potential. Women and girls in the community who have not experienced violence themselves may reduce their mobility and participation in order to avoid the violence they have heard that others have experienced.
“… It depends. People may decide to vote against her, or ask her to step down because they think she might not be a good example to the younger ones. At other times too, they may decide to help her fight against the violence she may be experiencing from her partner…” - Urban In-Depth Interview, Female
When women reduce their participation and involvement, communities experience a loss of input that undermines genuine democratic functioning. Considering the high proportion of women in Ghana who experience violence, the potential consequences of even a small percentage of them reducing leadership activities and participation, is substantial.
4.4 Impacts on the economy
The economic implications of VAWG at individual, household and community levels impact the overall economy via productivity loss. Productivity loss emerged as an impact that women and households experience and discussed within the qualitative research. A participant in a focus group with young urban women remarked:
“[A woman who is abused by her husband] will not be able to focus on her work so her income level will reduce. If you are working for someone, and you always have a divided attention, you will not be able to meet your set target.” -Urban Focus Group Discussion, Female
In the quantitative survey, productivity loss was probed through measuring absenteeism (missing work), tardiness (being late or leaving early by an hour), and presenteeism (being less productive or having less focus, low concentration, working slowly, stopping work or having an accident). The estimates of productivity loss due to IPV and VAWG more broadly were derived as the difference in means between working women experiencing violence and those not experiencing violence.
For women who experience IPV, the productivity loss was equivalent to 12 working days per woman in the past 12 months; nearly two-thirds of this loss is due to being less productive at work and the remaining one third is due to absenteeism (see Table 3). For women experiencing any form of violence across various locations, the total days of lost productivity is 26 days per woman in the past 12 months. This translates into nearly 65 million days at the national level or equivalent to 216,000 employed women not working, assuming women work 300 days in the year. Overall, the economy is estimated to lose output equivalent to 5% of its female workforce not working annually due to VAWG.
Category
Due to partner violence
Due to any violence
Mean days lost
Total days lost
Mean days lost
Total days lost
Absenteeism
4.1
4,714,811
15.14
37,042,551
Presenteeism
7.49
8,601,655
11.27
27,789,032
Total
11.59
13,316,465
26.41
64,831,583
Table 3.
National estimate of productivity loss due to violence [20].
Notes for calculation of mean and total days lost:
-The weighted IPV prevalence rate among working women = 24.13% (based on study survey).
-The weighted any violence prevalence rate among working women = 51.47% (based on study survey).
-Used estimated number of women aged 18–60 in Ghana as of 2016 = 7,377,138 (Ghana Statistical Service—GSS).
-Used the employment rate of women 15+ 2016 = 64.6% (Ghana Labour Force Survey).
The impact of annual loss of output combined with the ongoing negative consequences for the capability and participation of women establishes the systematic but unrecognised drain that violence against women and girls imposes on the economic prosperity and societal well-being of the nation.
5. Conclusion
In this mixed methods study, we found that VAWG is a persistent public health problem that affects women and girls who experience it, as well as their families and communities. Almost half of the women who participated in the women’s survey reported having experienced physical, psychological, sexual, or economic violence in the home, workplace, educational institution, or public space in the past 12 months. The violence women and girls experience varies in severity. It also varies by type of perpetrator and place of experience. Women reported experiencing violence in educational institutions, in public spaces, such as the market, on public transportation or on streets, in their work places, and at home. Nevertheless, it was also found that the home was the most dangerous place for women in Ghana.
This study also found that there are clear negative impacts on the health and well-being of survivors of VAWG. The effects that we identified have far-reaching consequences that go beyond immediate injuries (whether physical or psychological) to affect women’s ability to work, learn, and socialise. Participants in the study identified physical, reproductive, and mental health impacts. The study also found a statistically significant correlation between an illness score, a depression score, and experiencing any form of IPV.
The effects of VAWG on the health of women who have experienced violence affect other areas of their lives, creating a complex net of effects that goes beyond their individual health and well-being to affect their livelihood, through the impact of VAWG on the women and girls’ capabilities, with economic costs that have to be covered by women and girls and their families. Family members’ health may also be affected by VAWG. More subtle and difficult to notice are the costs that VAWG brings to the communities and countries.
VAWG also affects community cohesion and, according to the participants in our study, is often underestimated given that women and girls hardly ever report VAWG to formal authorities. The overall economy of Ghana is impacted due to the productivity loss that results from VAWG.
The study highlights the importance of research on costs/impacts of violence that recognise the social embeddedness of individuals and their locations within broader ecological systems. Such approaches go beyond simplistic accounts of immediate injuries and impacts but rather recognize how negative impacts ripple outwards—both through social networks as well as through time—thus creating much more substantive impacts with consequences for societies, economies and generations. While this study focused on Ghana, similar effects have been identified in South Sudan [23] and are likely to be replicated throughout countries in Africa. Further studies on the costs of VAWG are recommended, particularly longitudinal studies that can produce robust evidence of the long-term consequences of VAWG on capabilities in developing countries.
This study identifies the serious and long-lasting costs of VAWG to individuals, households, communities and economy through assessment of data from Ghana. The evidence generated by this study can be used by advocates across developing, low-to-middle income countries in Africa to influence policy makers and stakeholders, showing them the importance of investing funds in sustainable actions to prevent VAWG. Given the lack of funding for shelters and treatment for women and girls who experience violence, the authors suggest increasing the funding for support services, treatment and prevention initiatives. Such investments are sure to yield high returns—reducing the human and financial losses that impact on the health of populations and, ultimately, achieving development goals.
Acknowledgments
The project that forms the basis for this chapter was made possible by funding from the UK Department for International Development through the What Works to Prevent Violence against Women and Girls programme. We would also like to acknowledge the contributions of Felix Asante, University of Ghana, who oversaw the project in Ghana, Carol Ballantine, National University of Ireland, for her assistance with the literature review, and Mrinal Chadha for his work on quantitative analysis. We would also like to acknowledge the research team in Ghana who undertook data collection.
Conflict of interest
The authors declare no conflict of interest.
Notes/thanks/other declarations
We gratefully acknowledge the women who willingly gave their time to share their experiences and insights on the impacts of violence for them and their communities.
\n',keywords:"violence against women, intimate partner violence, costs of violence",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/68628.pdf",chapterXML:"https://mts.intechopen.com/source/xml/68628.xml",downloadPdfUrl:"/chapter/pdf-download/68628",previewPdfUrl:"/chapter/pdf-preview/68628",totalDownloads:859,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,introChapter:null,impactScore:0,impactScorePercentile:26,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"April 18th 2019",dateReviewed:"July 18th 2019",datePrePublished:"October 28th 2019",datePublished:"September 9th 2020",dateFinished:"August 19th 2019",readingETA:"0",abstract:"Violence against women and girls (VAWG) is a worldwide phenomenon. Globally, 35% of women have experienced physical or sexual intimate partner violence (IPV) or non-partner sexual violence in their lives. VAWG is estimated to cost the global economy about US$ eight trillion. Most studies on violence in Ghana discuss domestic violence or some forms of sexual violence but lack a comprehensive view of VAWG and its costs and impacts on communities, businesses, and the national economy. Our international consortium undertook a mixed-methods study to estimate the economic and non-economic losses caused by VAWG. We surveyed 2002 women and 805 male and female employees and conducted 24 in-depth interviews (IDIs) and 8 focus group discussions (FGDs). The study finds that costs of VAWG are high and multi-fold. It estimates costs to health, social relationships, and productivity for individuals, their families, and communities. Individual well-being and capabilities are impacted through absenteeism or missed care work and mental health issues. VAWG deepens household poverty by out-of-pocket expenditures that arise to address medical and legal issues that result from violence. Additionally, VAWG affects the vibrancy of communities as women’s participation and leadership decline. These costs accumulate to have profound effects on the Ghanaian economy and society.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/68628",risUrl:"/chapter/ris/68628",book:{id:"9138",slug:"public-health-in-developing-countries-challenges-and-opportunities"},signatures:"Gina Alvarado Merino, Stacey Scriver, Jennifer L. Mueller, Lila O’Brien-Milne, Ama P. Fenny and Nata Duvvury",authors:[{id:"302382",title:"Dr.",name:"Gina",middleName:null,surname:"Alvarado",fullName:"Gina Alvarado",slug:"gina-alvarado",email:"ginaa@landesa.org",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002mZoL9QAK/Profile_Picture_2022-05-26T08:14:10.jpg",institution:{name:"Landesa Rural Development Institute",institutionURL:null,country:{name:"United States of America"}}},{id:"303963",title:"Dr.",name:"Nata",middleName:null,surname:"Duvvury",fullName:"Nata Duvvury",slug:"nata-duvvury",email:"nata.duvvury@nuigalway.ie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"National University of Ireland, Galway",institutionURL:null,country:{name:"Ireland"}}},{id:"303964",title:"Dr.",name:"Stacey",middleName:null,surname:"Scriver",fullName:"Stacey Scriver",slug:"stacey-scriver",email:"stacey.scriver@nuigalway.ie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"National University of Ireland, Galway",institutionURL:null,country:{name:"Ireland"}}},{id:"309167",title:"Ms.",name:"Jennifer",middleName:null,surname:"Mueller",fullName:"Jennifer Mueller",slug:"jennifer-mueller",email:"jlmueller41@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"309168",title:"Ms.",name:"Lila",middleName:null,surname:"O'Brien-Milne",fullName:"Lila O'Brien-Milne",slug:"lila-o'brien-milne",email:"lilaobrienmilne@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"309169",title:"Dr.",name:"Ama",middleName:null,surname:"Fenny",fullName:"Ama Fenny",slug:"ama-fenny",email:"amafenny@yahoo.co.uk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Literature/state of knowledge",level:"1"},{id:"sec_3",title:"3. Methodology",level:"1"},{id:"sec_4",title:"4. Findings and discussion",level:"1"},{id:"sec_4_2",title:"4.1 Impacts on women’s health, well-being, and capabilities",level:"2"},{id:"sec_4_3",title:"Table 2.",level:"3"},{id:"sec_5_3",title:"4.1.2 Impacts on capabilities due to VAWG",level:"3"},{id:"sec_7_2",title:"4.2 Impacts to households",level:"2"},{id:"sec_7_3",title:"4.2.1 Health effects on the relatives of survivors",level:"3"},{id:"sec_8_3",title:"4.2.2 Economic costs",level:"3"},{id:"sec_9_3",title:"4.2.3 Impacts on the children of survivors",level:"3"},{id:"sec_11_2",title:"4.3 Impacts to community and participation",level:"2"},{id:"sec_11_3",title:"4.3.1 Help-seeking behaviour and service usage",level:"3"},{id:"sec_12_3",title:"4.3.2 Women’s participation in the community and leadership",level:"3"},{id:"sec_14_2",title:"4.4 Impacts on the economy",level:"2"},{id:"sec_16",title:"5. Conclusion",level:"1"},{id:"sec_17",title:"Acknowledgments",level:"1"},{id:"sec_20",title:"Conflict of interest",level:"1"},{id:"sec_17",title:"Notes/thanks/other declarations",level:"1"}],chapterReferences:[{id:"B1",body:'WHO, Department of Reproductive Health and Research, London School of Hygiene and Tropical Medicine, South African Medical Research Council. Global and Regional Estimates of Violence against Women: Prevalence and Health Effects of Intimate Partner Violence and Nonpartner Sexual Violence; 2013'},{id:"B2",body:'World Economic Forum. The Global Gender Gap Report; 2016'},{id:"B3",body:'Ghana Statistical Service, Ghana Health Service and Macro I. Ghana Demographic and Health Survey 2008. Accra, Ghana: GSS, GHS, and ICF Macro; 2009'},{id:"B4",body:'IDS, GSS and Associates. Domestic Violence in Ghana: Incidents, Attitudes, Determinants and Behaviours; 2016'},{id:"B5",body:'Amoakohene MI. Violence against women in Ghana: A look at women’s perceptions and review of policy and social responses. Social Science & Medicine. 2004;59:2373-2385'},{id:"B6",body:'Committee on the Elimination of Discrimination against Women. Concluding Observations on the Combined Sixth and Seventh Periodic Reports of Ghana; 2014'},{id:"B7",body:'Ballantine C, Fenny A, Asante F, Duvvury N. Working Paper No. 4—Ghana: The Economic and Social Impact of Violence against Women and Girls (VAWG); 2017'},{id:"B8",body:'Bowman CG. Theories of domestic violence in the African context. Journal of Gender, Social Policy & the Law. 2003;11:847-863'},{id:"B9",body:'Hunnicutt G. Varieties of patriarchy and violence against women: Resurrecting “patriarchy” as a theoretical tool. Violence Against Women. 2009;15:553-573'},{id:"B10",body:'Heise L. Violence against women: An integrated, ecological framework. Violence Against Women. 1998;4:262-290'},{id:"B11",body:'Fulu F, Heise L. What Do we Know about Violence against Women and Girls and What More Do we Need to Know to Prevent it? A Summary of the Evidence; 2014'},{id:"B12",body:'Issahaku PA. Health implications of partner violence against women in Ghana. Violence and Victims. 2015;30:250-264'},{id:"B13",body:'Sedziafa AP, Tenkorang EY, Owusu AY. Kinship and intimate partner violence among married women in Ghana: A qualitative exploration. Journal of Interpersonal Violence. 2016;33:2197-2224'},{id:"B14",body:'Essel PI. Effects of Violence against Women on the Socio-Economic Growth of the Nation; WiLDAF Ghana; 2016'},{id:"B15",body:'Cantalupo NC, Martin LV, Pak K, Shin S. Domestic violence in Ghana: The open secret. The Georgetown Journal of Gender and the Law. 2006;7:10-56'},{id:"B16",body:'Danso J. State Must Support Domestic Violence Victims-Court. Ghana News Agency; 2017'},{id:"B17",body:'Ministry of Gender, Children and Social Protection. National Gender Policy. Theme/Ghana: Mainstreaming Gender Equality and Women’s Empowerment into Ghana’s Development Efforts; 2015'},{id:"B18",body:'Domestic Violence Act, c.732 Ghana; 2007. Available from: http://www.ilo.org/dyn/natlex/docs/ELECTRONIC/88525/101248/F503368907/GHA88525.pdf'},{id:"B19",body:'Government of Ghana. National Gender Policy; 2015. Available from: http://www.ilo.org/dyn/natlex/docs/ELECTRONIC/103987/126660/F-515436150/GHA103987.pdf'},{id:"B20",body:'Asante F, Fenny A, Dzudzor M, Chadha M, Scriver S, Ballantine C, et al. Economic and Social Costs of Violence Against Women and Girls in Ghana: Country Technical Report. NUI Galway: Galway; 2019. p. 59'},{id:"B21",body:'Addo-Lartey A, Alangea D, Sikweyiya Y, Chirwa E, Coker-Appiah D, Jewkes R, et al. Rural response system to prevent violence against women: Methodology for a community randomised controlled trial in the central region of Ghana. Global Health Action. 2019;12:1. DOI: 10.1080/16549716.2019.1612604'},{id:"B22",body:'Duvvury N, Grown C, Redner J. Costs of Intimate Partner Violence at the Household and Community Levels: An Operational Framework for Developing Countries; ICRW. 2004'},{id:"B23",body:'Elmusharaf K, Scriver S, Chadha M, Ballantine C, Sabir M, Raghavendra S, et al. Economic and Social Costs of Violence Against Women and Girls in South Sudan: Country Technical Report. NUI Galway: Galway; 2019. Available from: https://whatworks.co.za/resources/reports/item/594-economic-and-social-costs-of-violence-against-women-in-south-sudan-technical-report'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Gina Alvarado Merino",address:null,affiliation:'
Centre for Global Women’s Studies, National University of Ireland Galway, Ireland
'}],corrections:null},book:{id:"9138",type:"book",title:"Public Health in Developing Countries",subtitle:"Challenges and Opportunities",fullTitle:"Public Health in Developing Countries - Challenges and Opportunities",slug:"public-health-in-developing-countries-challenges-and-opportunities",publishedDate:"September 9th 2020",bookSignature:"Edlyne Eze Anugwom and Niyi Awofeso",coverURL:"https://cdn.intechopen.com/books/images_new/9138.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-874-7",printIsbn:"978-1-78985-873-0",pdfIsbn:"978-1-83962-380-6",reviewType:"peer-reviewed",numberOfWosCitations:5,isAvailableForWebshopOrdering:!0,editors:[{id:"293469",title:null,name:"Edlyne Eze",middleName:null,surname:"Anugwom",slug:"edlyne-eze-anugwom",fullName:"Edlyne Eze Anugwom"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"36610",title:"Prof.",name:"Niyi",middleName:null,surname:"Awofeso",slug:"niyi-awofeso",fullName:"Niyi Awofeso"},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1131"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"72687",type:"chapter",title:"Introductory Chapter: Public Health Afflictions and Challenges in the Developing World",slug:"introductory-chapter-public-health-afflictions-and-challenges-in-the-developing-world",totalDownloads:400,totalCrossrefCites:1,signatures:"Edlyne Eze Anugwom",reviewType:"peer-reviewed",authors:[{id:"293469",title:null,name:"Edlyne Eze",middleName:null,surname:"Anugwom",fullName:"Edlyne Eze Anugwom",slug:"edlyne-eze-anugwom"}]},{id:"69468",type:"chapter",title:"The Global Burden and Perspectives on Non-Communicable Diseases (NCDs) and the Prevention, Data Availability and Systems Approach of NCDs in Low-resource Countries",slug:"the-global-burden-and-perspectives-on-non-communicable-diseases-ncds-and-the-prevention-data-availab",totalDownloads:2772,totalCrossrefCites:7,signatures:"Melkamu Kassa and Jeanne Grace",reviewType:"peer-reviewed",authors:[{id:"306689",title:"Dr.",name:"Melkamu",middleName:null,surname:"Kassa",fullName:"Melkamu Kassa",slug:"melkamu-kassa"},{id:"306691",title:"Dr.",name:"Grace",middleName:null,surname:"Jeanne",fullName:"Grace Jeanne",slug:"grace-jeanne"}]},{id:"69370",type:"chapter",title:"Non-Communicable Diseases and Urbanization in African Cities: A Narrative Review",slug:"non-communicable-diseases-and-urbanization-in-african-cities-a-narrative-review",totalDownloads:1363,totalCrossrefCites:5,signatures:"Kenneth Juma, Pamela A. Juma, Constance Shumba, Peter Otieno and Gershim Asiki",reviewType:"peer-reviewed",authors:[{id:"304657",title:"Dr.",name:"Kenneth",middleName:null,surname:"Juma",fullName:"Kenneth Juma",slug:"kenneth-juma"},{id:"310042",title:"Dr.",name:"Gershim",middleName:null,surname:"Asiki",fullName:"Gershim Asiki",slug:"gershim-asiki"},{id:"310043",title:"Dr.",name:"Pamela",middleName:null,surname:"Juma",fullName:"Pamela Juma",slug:"pamela-juma"},{id:"310045",title:"Dr.",name:"Peter",middleName:"O",surname:"Otieno",fullName:"Peter Otieno",slug:"peter-otieno"},{id:"310059",title:"Dr.",name:"Constance",middleName:null,surname:"Shumba",fullName:"Constance Shumba",slug:"constance-shumba"}]},{id:"71667",type:"chapter",title:"Health Promotion and Its Challenges to Public Health Delivery System in Africa",slug:"health-promotion-and-its-challenges-to-public-health-delivery-system-in-africa",totalDownloads:1520,totalCrossrefCites:1,signatures:"Edlyne Eze Anugwom",reviewType:"peer-reviewed",authors:[{id:"293469",title:null,name:"Edlyne Eze",middleName:null,surname:"Anugwom",fullName:"Edlyne Eze Anugwom",slug:"edlyne-eze-anugwom"}]},{id:"72878",type:"chapter",title:"Understanding the Science of Indigenous Health System: Key to Sustainable Collaborations",slug:"understanding-the-science-of-indigenous-health-system-key-to-sustainable-collaborations",totalDownloads:690,totalCrossrefCites:0,signatures:"Mbulaheni S. Nemutandani, SJH Hendrick and FM Mulaudzi",reviewType:"peer-reviewed",authors:[{id:"304220",title:"Prof.",name:"Simon",middleName:null,surname:"Nemutandani",fullName:"Simon Nemutandani",slug:"simon-nemutandani"}]},{id:"72270",type:"chapter",title:"Public Health Effects of Wood Fuel in Africa: Bioenergy from Tree Commodities as a Sustainable Remedy",slug:"public-health-effects-of-wood-fuel-in-africa-bioenergy-from-tree-commodities-as-a-sustainable-remedy",totalDownloads:750,totalCrossrefCites:0,signatures:"Serge Mandiefe Piabuo and Janice Tieguhong Puatwoe",reviewType:"peer-reviewed",authors:[{id:"237109",title:"M.Sc.",name:"Serge Mandiefe",middleName:null,surname:"Piabuo",fullName:"Serge Mandiefe Piabuo",slug:"serge-mandiefe-piabuo"},{id:"310642",title:"MSc.",name:"Janice",middleName:null,surname:"Tieguhong Puatwoe",fullName:"Janice Tieguhong Puatwoe",slug:"janice-tieguhong-puatwoe"}]},{id:"69631",type:"chapter",title:"Cultural Practices and Health Consequences: Health or Habits, the Choice Is Ours",slug:"cultural-practices-and-health-consequences-health-or-habits-the-choice-is-ours",totalDownloads:916,totalCrossrefCites:0,signatures:"Radiance Ogundipe",reviewType:"peer-reviewed",authors:[{id:"302308",title:"Dr.",name:"Radiance",middleName:null,surname:"Ogundipe",fullName:"Radiance Ogundipe",slug:"radiance-ogundipe"}]},{id:"70667",type:"chapter",title:"Mitigating the Hazard of Lightning Injury and Death across Africa",slug:"mitigating-the-hazard-of-lightning-injury-and-death-across-africa",totalDownloads:856,totalCrossrefCites:0,signatures:"Mary Ann Cooper, Ronald L. Holle and Richard Tushemereirwe",reviewType:"peer-reviewed",authors:[{id:"183336",title:"Dr.",name:"Mary Ann",middleName:null,surname:"Cooper",fullName:"Mary Ann Cooper",slug:"mary-ann-cooper"},{id:"305781",title:"Mr.",name:"Ronald L.",middleName:null,surname:"Holle",fullName:"Ronald L. Holle",slug:"ronald-l.-holle"},{id:"309128",title:"Mr.",name:"Richard",middleName:null,surname:"Tushemereirwe",fullName:"Richard Tushemereirwe",slug:"richard-tushemereirwe"}]},{id:"72196",type:"chapter",title:"Leprosy: Prevention and Control",slug:"leprosy-prevention-and-control",totalDownloads:895,totalCrossrefCites:0,signatures:"Vaseem Anjum",reviewType:"peer-reviewed",authors:[{id:"303053",title:"M.D.",name:"Vaseem",middleName:null,surname:"Anjum",fullName:"Vaseem Anjum",slug:"vaseem-anjum"}]},{id:"68036",type:"chapter",title:"Laser Applications in Periodontology",slug:"laser-applications-in-periodontology",totalDownloads:1274,totalCrossrefCites:1,signatures:"Sura Dakhil Jassim",reviewType:"peer-reviewed",authors:[{id:"302461",title:"Dr.",name:"Sura",middleName:null,surname:"Jassim",fullName:"Sura Jassim",slug:"sura-jassim"}]},{id:"71202",type:"chapter",title:"Development of a Rough Terrain Wheelchair Design",slug:"development-of-a-rough-terrain-wheelchair-design",totalDownloads:522,totalCrossrefCites:0,signatures:"Ignatio Madanhire, Loice Gudukeya and Roy Mushonga",reviewType:"peer-reviewed",authors:[{id:"282665",title:"Dr.",name:"Ignatio",middleName:null,surname:"Madanhire",fullName:"Ignatio Madanhire",slug:"ignatio-madanhire"},{id:"315729",title:"Mr.",name:"Roy",middleName:null,surname:"Mushonga",fullName:"Roy Mushonga",slug:"roy-mushonga"},{id:"315730",title:"Dr.",name:"Loice",middleName:null,surname:"Gudukeya",fullName:"Loice Gudukeya",slug:"loice-gudukeya"}]},{id:"70815",type:"chapter",title:"Temporal Trend and Inequality in Immunization Coverage in India",slug:"temporal-trend-and-inequality-in-immunization-coverage-in-india",totalDownloads:660,totalCrossrefCites:1,signatures:"Basant Kumar Panda",reviewType:"peer-reviewed",authors:[{id:"302712",title:"Mr.",name:"Basant",middleName:"Kumar",surname:"Panda",fullName:"Basant Panda",slug:"basant-panda"}]},{id:"70021",type:"chapter",title:"Social and Institutional Support in Breast Cancer Management among Elderly Women in Nigeria",slug:"social-and-institutional-support-in-breast-cancer-management-among-elderly-women-in-nigeria",totalDownloads:617,totalCrossrefCites:0,signatures:"Kenechukwu N. Anugwom",reviewType:"peer-reviewed",authors:[{id:"302831",title:"Dr.",name:"Kenechukwu",middleName:null,surname:"Anugwom",fullName:"Kenechukwu Anugwom",slug:"kenechukwu-anugwom"}]},{id:"68628",type:"chapter",title:"The Health and Economic Costs of Violence against Women and Girls on Survivors, Their Families, and Communities in Ghana",slug:"the-health-and-economic-costs-of-violence-against-women-and-girls-on-survivors-their-families-and-co",totalDownloads:859,totalCrossrefCites:0,signatures:"Gina Alvarado Merino, Stacey Scriver, Jennifer L. Mueller, Lila O’Brien-Milne, Ama P. Fenny and Nata Duvvury",reviewType:"peer-reviewed",authors:[{id:"302382",title:"Dr.",name:"Gina",middleName:null,surname:"Alvarado",fullName:"Gina Alvarado",slug:"gina-alvarado"},{id:"303963",title:"Dr.",name:"Nata",middleName:null,surname:"Duvvury",fullName:"Nata Duvvury",slug:"nata-duvvury"},{id:"303964",title:"Dr.",name:"Stacey",middleName:null,surname:"Scriver",fullName:"Stacey Scriver",slug:"stacey-scriver"},{id:"309167",title:"Ms.",name:"Jennifer",middleName:null,surname:"Mueller",fullName:"Jennifer Mueller",slug:"jennifer-mueller"},{id:"309168",title:"Ms.",name:"Lila",middleName:null,surname:"O'Brien-Milne",fullName:"Lila O'Brien-Milne",slug:"lila-o'brien-milne"},{id:"309169",title:"Dr.",name:"Ama",middleName:null,surname:"Fenny",fullName:"Ama Fenny",slug:"ama-fenny"}]},{id:"69588",type:"chapter",title:"Obesity in School Children in India",slug:"obesity-in-school-children-in-india",totalDownloads:1436,totalCrossrefCites:1,signatures:"Vangal Krishnaswamy Sashindran and Puja Dudeja",reviewType:"peer-reviewed",authors:[{id:"241625",title:"Dr.",name:"V K",middleName:null,surname:"Sashindran",fullName:"V K Sashindran",slug:"v-k-sashindran"},{id:"310983",title:"Dr.",name:"Puja",middleName:null,surname:"Dudeja",fullName:"Puja Dudeja",slug:"puja-dudeja"}]},{id:"70556",type:"chapter",title:"Innovations in Vector-Borne Disease Control in India",slug:"innovations-in-vector-borne-disease-control-in-india",totalDownloads:600,totalCrossrefCites:0,signatures:"Susanta Kumar Ghosh and Chaitali Ghosh",reviewType:"peer-reviewed",authors:[{id:"301164",title:"Prof.",name:"Susanta",middleName:null,surname:"Ghosh",fullName:"Susanta Ghosh",slug:"susanta-ghosh"},{id:"306830",title:"Dr.",name:"Chaitali",middleName:null,surname:"Ghosh",fullName:"Chaitali Ghosh",slug:"chaitali-ghosh"}]}]},relatedBooks:[{type:"book",id:"6339",title:"Towards Malaria Elimination",subtitle:"A Leap Forward",isOpenForSubmission:!1,hash:"2ab88726cd9291b2b1c29889c948c902",slug:"towards-malaria-elimination-a-leap-forward",bookSignature:"Sylvie Manguin and Vas Dev",coverURL:"https://cdn.intechopen.com/books/images_new/6339.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"61376",title:"Malaria Elimination: Challenges and Opportunities",slug:"malaria-elimination-challenges-and-opportunities",signatures:"Umberto D’Alessandro",authors:[{id:"214368",title:"Prof.",name:"Umberto",middleName:null,surname:"D'Alessandro",fullName:"Umberto D'Alessandro",slug:"umberto-d'alessandro"}]},{id:"60988",title:"The Artemisinin Resistance in Southeast Asia: An Imminent Global Threat to Malaria Elimination",slug:"the-artemisinin-resistance-in-southeast-asia-an-imminent-global-threat-to-malaria-elimination",signatures:"Aung Pyae Phyo and François Nosten",authors:[{id:"214099",title:"Dr.",name:"Aung",middleName:null,surname:"Pyae Phyo",fullName:"Aung Pyae Phyo",slug:"aung-pyae-phyo"},{id:"215774",title:"Prof.",name:"Francois",middleName:null,surname:"Nosten",fullName:"Francois Nosten",slug:"francois-nosten"}]},{id:"62029",title:"Preparing for the Next Global Threat: A Call for Targeted, Immediate Decisive Action in Southeast Asia to Prevent the Next Pandemic in Africa",slug:"preparing-for-the-next-global-threat-a-call-for-targeted-immediate-decisive-action-in-southeast-asia",signatures:"Colin Ohrt, Thang Duc Ngo and Thieu Quang Nguyen",authors:[{id:"217746",title:"Dr.",name:"Colin",middleName:null,surname:"Ohrt",fullName:"Colin Ohrt",slug:"colin-ohrt"},{id:"240534",title:"Dr.",name:"Thang Duc",middleName:null,surname:"Ngo",fullName:"Thang Duc Ngo",slug:"thang-duc-ngo"},{id:"240535",title:"Dr.",name:"Thieu Quang",middleName:null,surname:"Nguyen",fullName:"Thieu Quang Nguyen",slug:"thieu-quang-nguyen"}]},{id:"61584",title:"Challenges in the Control and Elimination of Plasmodium vivax Malaria",slug:"challenges-in-the-control-and-elimination-of-plasmodium-vivax-malaria",signatures:"Puji BS Asih, Din Syafruddin and John Kevin Baird",authors:[{id:"216332",title:"Dr.",name:"Puji",middleName:"Budi Setia",surname:"Budi Setia Asih",fullName:"Puji Budi Setia Asih",slug:"puji-budi-setia-asih"},{id:"216335",title:"Dr.",name:"Kevin",middleName:null,surname:"Baird",fullName:"Kevin Baird",slug:"kevin-baird"},{id:"239838",title:"Prof.",name:"Din",middleName:null,surname:"Syafruddin",fullName:"Din Syafruddin",slug:"din-syafruddin"}]},{id:"61329",title:"Human and Simian Malaria in the Greater Mekong Subregion and Challenges for Elimination",slug:"human-and-simian-malaria-in-the-greater-mekong-subregion-and-challenges-for-elimination",signatures:"Jeffrey Hii, Indra Vythilingam and Arantxa Roca-Feltrer",authors:[{id:"151116",title:"Dr.",name:"Indra",middleName:null,surname:"Vythilingam",fullName:"Indra Vythilingam",slug:"indra-vythilingam"},{id:"214902",title:"Dr.",name:"Arantxa",middleName:null,surname:"Roca-Feltrer",fullName:"Arantxa Roca-Feltrer",slug:"arantxa-roca-feltrer"},{id:"215079",title:"Dr.",name:"Jeffrey",middleName:null,surname:"Hii",fullName:"Jeffrey Hii",slug:"jeffrey-hii"}]},{id:"61559",title:"Understanding the Importance of Asymptomatic and Low- Density Infections for Malaria Elimination",slug:"understanding-the-importance-of-asymptomatic-and-low-density-infections-for-malaria-elimination",signatures:"Chris Drakeley, Bronner Gonçalves, Lucy Okell and Hannah Slater",authors:[{id:"215238",title:"Prof.",name:"Chris",middleName:null,surname:"Drakeley",fullName:"Chris Drakeley",slug:"chris-drakeley"},{id:"215831",title:"Dr.",name:"Bronner",middleName:null,surname:"Goncalves",fullName:"Bronner Goncalves",slug:"bronner-goncalves"},{id:"215834",title:"Dr.",name:"Hannah",middleName:null,surname:"Slater",fullName:"Hannah Slater",slug:"hannah-slater"},{id:"215835",title:"Dr.",name:"Lucy",middleName:null,surname:"Okell",fullName:"Lucy Okell",slug:"lucy-okell"}]},{id:"62169",title:"Insecticide Resistance in Malaria Vectors: An Update at a Global Scale",slug:"insecticide-resistance-in-malaria-vectors-an-update-at-a-global-scale",signatures:"Jacob M. Riveron, Magellan Tchouakui, Leon Mugenzi, Benjamin D.\nMenze, Mu-Chun Chiang and Charles S. Wondji",authors:[{id:"212661",title:"Dr.",name:"Charles",middleName:null,surname:"Wondji",fullName:"Charles Wondji",slug:"charles-wondji"},{id:"215729",title:"Dr.",name:"Jacob",middleName:null,surname:"Riveron",fullName:"Jacob Riveron",slug:"jacob-riveron"},{id:"215730",title:"MSc.",name:"Magellan",middleName:null,surname:"Tchouakui",fullName:"Magellan Tchouakui",slug:"magellan-tchouakui"},{id:"215731",title:"MSc.",name:"Leon",middleName:null,surname:"Mugenzi",fullName:"Leon Mugenzi",slug:"leon-mugenzi"},{id:"215732",title:"MSc.",name:"Benjamin",middleName:null,surname:"Menze",fullName:"Benjamin Menze",slug:"benjamin-menze"},{id:"240599",title:"MSc.",name:"Mu-Chun",middleName:null,surname:"Chiang",fullName:"Mu-Chun Chiang",slug:"mu-chun-chiang"}]},{id:"60966",title:"Malaria Elimination in the Greater Mekong Subregion: Challenges and Prospects",slug:"malaria-elimination-in-the-greater-mekong-subregion-challenges-and-prospects",signatures:"Liwang Cui, Yaming Cao, Jaranit Kaewkungwal, Amnat\nKhamsiriwatchara, Saranath Lawpoolsri, Than Naing Soe, Myat\nPhone Kyaw and Jetsumon Sattabongkot",authors:[{id:"217491",title:"Dr.",name:"Liwang",middleName:null,surname:"Cui",fullName:"Liwang Cui",slug:"liwang-cui"},{id:"240119",title:"Prof.",name:"Yaming",middleName:null,surname:"Cao",fullName:"Yaming Cao",slug:"yaming-cao"},{id:"240120",title:"Prof.",name:"Jaranit",middleName:null,surname:"Kaewkungwal",fullName:"Jaranit Kaewkungwal",slug:"jaranit-kaewkungwal"},{id:"240121",title:"Mr.",name:"Amnat",middleName:null,surname:"Khamsiriwatchara",fullName:"Amnat Khamsiriwatchara",slug:"amnat-khamsiriwatchara"},{id:"240122",title:"Prof.",name:"Saranath",middleName:null,surname:"Lawpoolsri",fullName:"Saranath Lawpoolsri",slug:"saranath-lawpoolsri"},{id:"240123",title:"MSc.",name:"Than Naing",middleName:null,surname:"Soe",fullName:"Than Naing Soe",slug:"than-naing-soe"},{id:"240124",title:"Dr.",name:"Myat Phone",middleName:null,surname:"Kyaw",fullName:"Myat Phone Kyaw",slug:"myat-phone-kyaw"},{id:"240125",title:"Prof.",name:"Jetsumon",middleName:null,surname:"Sattabongkot",fullName:"Jetsumon Sattabongkot",slug:"jetsumon-sattabongkot"}]},{id:"59967",title:"Ending Malaria Transmission in the Asia Pacific Malaria Elimination Network (APMEN) Countries: Challenges and the Way Forward",slug:"ending-malaria-transmission-in-the-asia-pacific-malaria-elimination-network-apmen-countries-challeng",signatures:"Kinley Wangdi and Archie CA Clements",authors:[{id:"212325",title:"Dr.",name:"Kinley",middleName:null,surname:"Wangdi",fullName:"Kinley Wangdi",slug:"kinley-wangdi"},{id:"221224",title:"Prof.",name:"Archie",middleName:null,surname:"Clements",fullName:"Archie Clements",slug:"archie-clements"}]},{id:"61600",title:"Malaria Elimination in the People’s Republic of China: Current Progress, Challenges, and Prospects",slug:"malaria-elimination-in-the-people-s-republic-of-china-current-progress-challenges-and-prospects",signatures:"Shaosen Zhang, Li Zhang, Jun Feng, Jianhai Yin, Xinyu Feng, Zhigui\nXia, Roger Frutos, Sylvie Manguin and Shuisen Zhou",authors:[{id:"50017",title:"Prof.",name:"Sylvie",middleName:null,surname:"Manguin",fullName:"Sylvie Manguin",slug:"sylvie-manguin"},{id:"222596",title:"Prof.",name:"Roger",middleName:null,surname:"Frutos",fullName:"Roger Frutos",slug:"roger-frutos"},{id:"241436",title:"Dr.",name:"Shaosen",middleName:null,surname:"Zhang",fullName:"Shaosen Zhang",slug:"shaosen-zhang"},{id:"249302",title:"Prof.",name:"Shuisen",middleName:null,surname:"Zhou",fullName:"Shuisen Zhou",slug:"shuisen-zhou"},{id:"249874",title:"Ms.",name:"Li",middleName:null,surname:"Zhang",fullName:"Li Zhang",slug:"li-zhang"},{id:"249875",title:"Dr.",name:"Jun",middleName:null,surname:"Feng",fullName:"Jun Feng",slug:"jun-feng"},{id:"249876",title:"Dr.",name:"Jianhai",middleName:null,surname:"Yin",fullName:"Jianhai Yin",slug:"jianhai-yin"},{id:"249877",title:"Dr.",name:"Xinyu",middleName:null,surname:"Feng",fullName:"Xinyu Feng",slug:"xinyu-feng"},{id:"249880",title:"Dr.",name:"Zhigui",middleName:null,surname:"Xia",fullName:"Zhigui Xia",slug:"zhigui-xia"}]},{id:"61663",title:"Declining Transmission of Malaria in India: Accelerating Towards Elimination",slug:"declining-transmission-of-malaria-in-india-accelerating-towards-elimination",signatures:"Sunil Dhiman, Vijay Veer and Vas Dev",authors:[{id:"244465",title:"Dr.",name:"Sunil",middleName:null,surname:"Dhiman",fullName:"Sunil Dhiman",slug:"sunil-dhiman"},{id:"244466",title:"Dr.",name:"Vijay",middleName:null,surname:"Veer",fullName:"Vijay Veer",slug:"vijay-veer"},{id:"249455",title:"Dr.",name:"Vas",middleName:null,surname:"Dev",fullName:"Vas Dev",slug:"vas-dev"}]},{id:"62219",title:"Malaria Transmission in South America—Present Status and Prospects for Elimination",slug:"malaria-transmission-in-south-america-present-status-and-prospects-for-elimination",signatures:"Jan Evelyn Conn, Maria Eugenia Grillet, Margarita Correa and Maria\nAnice Mureb Sallum",authors:[{id:"154256",title:"Prof.",name:"Maria Anice",middleName:"Mureb",surname:"Sallum",fullName:"Maria Anice Sallum",slug:"maria-anice-sallum"},{id:"214033",title:"Prof.",name:"Jan",middleName:null,surname:"Conn",fullName:"Jan Conn",slug:"jan-conn"}]},{id:"60602",title:"Malaria Eradication in the European World: Historical Perspective and Imminent Threats",slug:"malaria-eradication-in-the-european-world-historical-perspective-and-imminent-threats",signatures:"Evangelia-Theophano Piperaki",authors:[{id:"213542",title:"Dr.",name:"Evangelia - Theophano",middleName:null,surname:"Piperaki",fullName:"Evangelia - Theophano Piperaki",slug:"evangelia-theophano-piperaki"}]},{id:"61237",title:"Assessing Malaria Vaccine Efficacy",slug:"assessing-malaria-vaccine-efficacy",signatures:"Laurent Rénia, Yun Shan Goh, Kaitian Peng, Marjorie Mauduit and\nGeorges Snounou",authors:[{id:"215401",title:"Prof.",name:"Laurent",middleName:null,surname:"Renia",fullName:"Laurent Renia",slug:"laurent-renia"},{id:"243625",title:"Dr.",name:"Yun Shan",middleName:null,surname:"Goh",fullName:"Yun Shan Goh",slug:"yun-shan-goh"},{id:"243626",title:"Dr.",name:"Katian",middleName:null,surname:"Peng",fullName:"Katian Peng",slug:"katian-peng"},{id:"243628",title:"Dr.",name:"Marjorie",middleName:null,surname:"Mauduit",fullName:"Marjorie Mauduit",slug:"marjorie-mauduit"},{id:"243629",title:"Dr.",name:"Georges",middleName:null,surname:"Snounou",fullName:"Georges Snounou",slug:"georges-snounou"}]},{id:"61993",title:"Malaria Transmission-Blocking Vaccines: Present Status and Future Perspectives",slug:"malaria-transmission-blocking-vaccines-present-status-and-future-perspectives",signatures:"Ogobara K. Doumbo, Karamoko Niaré, Sara A. Healy, Issaka Sagara\nand Patrick E. Duffy",authors:[{id:"220804",title:"Prof.",name:"Ogobara",middleName:"Keguerem",surname:"Doumbo",fullName:"Ogobara Doumbo",slug:"ogobara-doumbo"}]},{id:"60183",title:"Newer Approaches for Malaria Vector Control and Challenges of Outdoor Transmission",slug:"newer-approaches-for-malaria-vector-control-and-challenges-of-outdoor-transmission",signatures:"John C. Beier, André B.B. Wilke and Giovanni Benelli",authors:[{id:"212309",title:"Prof.",name:"John C.",middleName:null,surname:"Beier",fullName:"John C. Beier",slug:"john-c.-beier"},{id:"238235",title:"Dr.",name:"Andre",middleName:null,surname:"Wilke",fullName:"Andre Wilke",slug:"andre-wilke"},{id:"238241",title:"Dr.",name:"Giovanni",middleName:null,surname:"Benelli",fullName:"Giovanni Benelli",slug:"giovanni-benelli"}]},{id:"61802",title:"Entomological Surveillance as a Cornerstone of Malaria Elimination: A Critical Appraisal",slug:"entomological-surveillance-as-a-cornerstone-of-malaria-elimination-a-critical-appraisal",signatures:"Gerry F. Killeen, Prosper P. Chaki, Thomas E. Reed, Catherine L.\nMoyes and Nicodem J. Govella",authors:[{id:"217064",title:"Dr.",name:"Gerry",middleName:null,surname:"Killeen",fullName:"Gerry Killeen",slug:"gerry-killeen"}]}]}],publishedBooks:[{type:"book",id:"670",title:"Addictions",subtitle:"From Pathophysiology to Treatment",isOpenForSubmission:!1,hash:"9c807a142be4c589ba8d325568a2d9ae",slug:"addictions-from-pathophysiology-to-treatment",bookSignature:"David Belin",coverURL:"https://cdn.intechopen.com/books/images_new/670.jpg",editedByType:"Edited by",editors:[{id:"97877",title:"Dr.",name:"David",surname:"Belin",slug:"david-belin",fullName:"David Belin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"762",title:"Contemporary and Innovative Practice in Palliative Care",subtitle:null,isOpenForSubmission:!1,hash:"243832000765abc39fee7009494c2ab0",slug:"contemporary-and-innovative-practice-in-palliative-care",bookSignature:"Esther Chang and Amanda Johnson",coverURL:"https://cdn.intechopen.com/books/images_new/762.jpg",editedByType:"Edited by",editors:[{id:"86476",title:"Prof.",name:"Esther",surname:"Chang",slug:"esther-chang",fullName:"Esther Chang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1809",title:"Insight and Control of Infectious Disease in Global Scenario",subtitle:null,isOpenForSubmission:!1,hash:"3ef57f4cdbc59a806312c24bff4e3097",slug:"insight-and-control-of-infectious-disease-in-global-scenario",bookSignature:"Priti Kumar Roy",coverURL:"https://cdn.intechopen.com/books/images_new/1809.jpg",editedByType:"Edited by",editors:[{id:"95723",title:"Dr.",name:"Roy",surname:"Priti",slug:"roy-priti",fullName:"Roy Priti"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5171",title:"Recent Advances in Drug Addiction Research and Clinical Applications",subtitle:null,isOpenForSubmission:!1,hash:"d4d43741fe591f3102735d26db3c51a0",slug:"recent-advances-in-drug-addiction-research-and-clinical-applications",bookSignature:"William M. Meil and Christina L. Ruby",coverURL:"https://cdn.intechopen.com/books/images_new/5171.jpg",editedByType:"Edited by",editors:[{id:"87876",title:"Dr.",name:"William M.",surname:"Meil",slug:"william-m.-meil",fullName:"William M. Meil"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5387",title:"Worldwide Wound Healing",subtitle:"Innovation in Natural and Conventional Methods",isOpenForSubmission:!1,hash:"7fce44f4147d70a5f22ce850dedc729a",slug:"worldwide-wound-healing-innovation-in-natural-and-conventional-methods",bookSignature:"Cesar Joao Vicente da Fonseca",coverURL:"https://cdn.intechopen.com/books/images_new/5387.jpg",editedByType:"Edited by",editors:[{id:"182006",title:"Prof.",name:"César",surname:"Fonseca",slug:"cesar-fonseca",fullName:"César Fonseca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"9138",title:"Public Health in Developing Countries",subtitle:"Challenges and Opportunities",isOpenForSubmission:!1,hash:"28c7e86f71905feb65668941c4f259f4",slug:"public-health-in-developing-countries-challenges-and-opportunities",bookSignature:"Edlyne Eze Anugwom and Niyi Awofeso",coverURL:"https://cdn.intechopen.com/books/images_new/9138.jpg",editedByType:"Edited by",editors:[{id:"293469",title:null,name:"Edlyne Eze",surname:"Anugwom",slug:"edlyne-eze-anugwom",fullName:"Edlyne Eze Anugwom"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"80675",title:"Medicinal Mushroom Mycelia: Characteristics, Benefits, and Utility in Soybean Fermentation",doi:"10.5772/intechopen.102522",slug:"medicinal-mushroom-mycelia-characteristics-benefits-and-utility-in-soybean-fermentation",body:'
1. Introduction
Mushrooms, their fruiting bodies and mycelia have served as food and food supplements around the world. They are relatively less toxic and are rich in bioactive compounds, such as polysaccharides, proteins, minerals, and other nutrients [1]. Beneficial activities associated with mushroom fruiting bodies and mycelia include antitumor [2], antimutagenic [3], antiviral [4], and antioxidant activities [5]. Some mushrooms alleviate the risk of diseases, such as Parkinson’s and Alzheimer’s disease, and hypertension [6].
Mushroom mycelia contain bioactive compounds as well as mushroom fruiting bodies, which have been investigated for their medicinal value. For example, oral administration of Sparassis crispa mycelia resulted in antitumor responses in tumor-bearing ICR mice [7]. The ability of erinacines, the bioactive compounds of H. erinaceum mycelia, to promote nerve health has been documented [8]. However, published data on the bioactivity of mushroom mycelia are limited compared with those of mushroom fruiting bodies.
In this chapter, we first discuss the antioxidant activity of 20 different species of wild mushroom mycelia [9]. These mushrooms are considered edible in the Tohoku area in northern Japan. Second, we present our findings on the ability of the comb tooth cap medicinal mushroom, H. ramosum mycelia, to promote NGF synthesis [9]. Finally, we discuss our results from using these mushroom mycelia in soybean fermentation [10] and discuss the prospects of utilizing H. ramosum mycelia in soybean fermentation for large-scale production of aglycons.
2. Characteristics of wild mushroom mycelia
2.1 Collection of mushrooms and separation of mycelia
We investigated the characteristics of 20 species of mushrooms: #1, A. brasiliensis (Agaricaceae); #2, Mycoleptodonoides aitchisonii (Climacodontaceae); #3, Ganoderma applanatum and #4, G. lusidum (Ganodermataceae); #5, H. erinaceum and #6, Hericium ramosum (Hericiaceae); #7, Inonotus obliquus (Hymenochaetaceae); #8, Lentinus edodes (Pleurotaceae); #9, Dendropolyporus umbellatus; #10, Grifola frondosa; #11, Laetiporus sulphureus; #12, Polyporellus badius and #13, Polyporus tuberaster (Polyporaceae); #14, Sparassis crispa (Sparassidaceae); #15, Pholiota aurivella and #16, Pholiota nameko (Strophariaceae); #17, Hypsizygus marmoreus, #18, Lepista nuda; #19, Lyophyllum shimeji and #20, Panellus serotinus (Tricholomataceae).
Nineteen of these (#2–20) wild mushroom fruiting bodies were collected from the Akita and Iwate prefectures in the Tohoku area in northern Japan. A. brasiliensis (#1) mycelia were provided by Dr. Makoto Yoneyama, I.M.C. Institution (Yamanashi Prefecture, Japan). Pieces of mushroom fruiting bodies collected from natural sites were plated in a 90-mm Petri dish containing potato dextrose agar (PDA) medium and incubated at 25°C for 2 days until the mycelia germinated. Mycelia were allowed to germinate and then cultured for 14 days at 25°C, after which period, they were maintained at 3°C on PDA medium. Mushroom mycelia were grown in submerged culture following the methods of A. brasiliensis mycelia cultivation, as described previously [11]. The culture was incubated at 25°C for 14 days with gentle shaking and the mycelia were lyophilized by freeze-drying after cultivation.
2.2 Ethanol extract preparation from mushroom mycelia
Mushroom mycelia extraction with ethanol was performed following methods described in previous reports [12, 13] with a few modifications. Lyophilized mushroom mycelia (0.1 g) were extracted with 80% ethanol (10 mL) at 25°C for 24 h and the resulting solutions were concentrated and lyophilized to a powder.
2.3 Antioxidant activity of wild mushroom mycelia
Free radicals exert tissue damage through reactive oxygen species (ROS)-induced oxidative stress, which can be counterbalanced by antioxidants [14, 15]. ROS, such as superoxide anion radicals, hydroxyl radicals, and hydrogen peroxide (H2O2), induce aging and cell damage [16, 17], and have been implicated in several diseases [18]. Recent epidemiological data indicate the association between inactivation of ROS and the disease-prevention benefits resulting from consuming food containing antioxidants, such as fruits, vegetables, and certain cereals [19]. As a result, there is an increasing trend worldwide in the incorporation of antioxidant compounds and foods into regular diet. We measured the antioxidant activity of the 20 wild mushrooms listed above by DPPH radical scavenging activity assay.
2.3.1 Methods
Measurement of 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity of mushroom mycelia was performed as previously described [20]. Ethanol extracts of mushroom mycelia (0.3 mL) were mixed with 0.6 mL of 100 mM MES buffer (pH 6.0)/10% ethanol solution, and 0.3 mL of 400 μM DPPH in ethanol. The absorbance of the reaction mixture was quantified at 520 nm after the reaction was set to complete for 20 minutes at RT. The DPPH radical scavenging activity of mushroom mycelia was calculated from assay lines of Trolox (0, 5, 10, 15, 20, and 25 μM) and expressed as μmol Trolox/g dry powder.
2.3.2 DPPH free radical scavenging activity of mushroom mycelia
Eighty-percent ethanol extracts of mushroom mycelia were used for antioxidant activity measurements using DPPH radical scavenging activity (Figure 1). Among the 20 mushroom mycelia analyzed, L. shimeji (#19), G. frondosa (#10), H. erinaceum (#5), and H. ramosum (#6) showed more robust DPPH radical scavenging activities. Among the mycelia tested, H. ramosum showed maximum antioxidant activity, followed by H. erinaceum, G. frondosa, and L. shimeji.
Figure 1.
DPPH radical scavenging activity of mycelial extracts from the 20 wild mushrooms [9]. 1, A. brasiliensis; 2, M. aitchisonii; 3, G. applanata; 4, G. lucidum; 5, H. erinaceum; 6, H. ramosum; 7, I. obliquus; 8, L. edodes; 9, D. umbellatus; 10, G. frondosa; 11, L. sulphureus; 12, P. badius; 13, P. tuberaster; 14, S. crispa; 15, P. aurivella; 16, P. nameko; 17, H. marmoreus; 18, L. nuda; 19, L. shimeji; and 20, P. serotinus. The DPPH radical scavenging activity of mushroom mycelia was calculated and expressed as the Trolox equivalent. Data represent the mean ± SD (n = 5).
2.4 Total phenolic content of the wild mushroom mycelia
Phenolic compounds are secondary metabolites of plants produced as defensive responses to threatening environments, including pathogen attack and UV radiation [21]. Generally, these polyphenols are classified as phenolic acids, flavonoids, lignans, and stilbenes [22]. These phenolic compounds possess antioxidant, antiglycemic, anticarcinogenic, and anti-inflammatory properties and can protect against bacterial and viral infections [23]. We analyzed the total phenolic content of the mushroom mycelia.
2.4.1 Methods
Folin & Ciocalteu method [24] with catechin as a standard was used for analysis. Ethanol extracts of mushroom mycelia (1 mL) were mixed with 0.5 mL of Folin & Ciocalteu solution and 5 mL of 0.4 M sodium carbonate solution. The absorbance of the reaction mixture was quantified at 660 nm after the reaction was set to complete for 30 minutes at 30°C. Methods are described in detail in Suruga et al. [9].
2.4.2 Measurement of total phenolic content
The phenolic contents of the samples were expressed as mg of catechin equivalent/g dry powder in Figure 2. H. ramosum (#6) showed the highest amount of phenol contents, followed by H. erinaceum (#5), G. frondosa (#10), A. brasiliensis (#1), L. shimeji (#19), E. applanata (#3), G. lucidum (#4), and H. marmoreus (#17).
Figure 2.
Total phenolic content of wild mushrooms mycelia extracts [9]. 1, A. brasiliensis; 2, M. aitchisonii; 3, G. applanata; 4, G. lucidum; 5, H. erinaceum; 6, H. ramosum; 7, I. obliquus; 8, L. edodes; 9, D. umbellatus; 10, G. frondosa; 11, L. sulphureus; 12, P. badius; 13, P. tuberaster; 14, S. crispa; 15, P. aurivella; 16, P. nameko; 17, H. marmoreus; 18, L. nuda; 19, L. shimeji; and 20, P. serotinus. Data represent the mean ± SD (n = 5).
2.5 Phenolic compounds enable the DPPH radical scavenging capacity of mushroom mycelia
DPPH radical scavenging activity showed a significant correlation (R2 = 0.7929) with the total phenolic content in the wild mushroom mycelia extracts (Figure 3). The Hericiaceae group, including H. erinaceum (#5) and H. ramosum (#6), which had a higher total phenolic content, showed stronger antioxidant potential. All these results suggest that the DPPH radical scavenging capacity of these extracts is driven by the phenolic compounds.
Figure 3.
Direct correlation between DPPH radical scavenging activity and phenolic content [9].
3. NGF synthesis of H. ramosum mycelia
Senile dementia, such as AD, is a severe problem, with no effective therapy [25]. Neurotrophic factors, including NGF, brain-derived neurotrophic factor (BDNF), neurotrophin 3, and glial-derived neurotrophic factor (GDNF), have been implicated in the prevention of neuronal death and promotion of neurite outgrowth [26]. Among them, NGF has been associated with AD [27], with decreased NGF levels in the basal forebrain of AD patients. Intracerebroventricular administration of NGF has been reported to eliminate degeneration and resultant cognitive deficits in rats after brain injury [28]. In rats, poor cognitive effects caused by neuronal degeneration have been shown to be eliminated by intracerebroventricular administration of NGF. However, since NGF cannot cross the blood-brain barrier, utilizing it for therapeutic application will be difficult. Several studies have investigated low-molecular-weight compounds, such as catecholamines [29], benzoquinones [30], hericenones [31], and erinacines [32], for their ability to promote NGF synthesis.
H. erinaceum is a common fungus found in the East Asian diet. Hericenones [33] have been isolated from the fruiting bodies of H. erinaceum and erinacines [34] have been identified in H. erinaceum mycelia. H. erinaceum may be valuable in the treatment and prevention of dementia [35, 36]. However, to our knowledge, no reports have shown the induction of NGF synthesis by H. ramosum mycelia. In this section, we show the results of our assessment on the ability of H. erinaceum and H. ramosum mycelia to induce NGF synthesis.
3.1 Methods
NGF synthesis was measured as described by Hazekawa et al. [37]. Male ddY mice (25–30 g weight) obtained from Kiwa Laboratory Animals Co., Ltd. (Wakayama, Japan), were housed under a 12-h light/dark cycle at room temperature and 55 ± 5% humidity. The lyophilized mycelia from H. erinaceum and H. ramosum were suspended in purified water and the samples were orally administrated to mice once a day for 14 days. NGF levels were analyzed in the cortex, striatum, and hippocampus 24 h after the last administration. Results are expressed as mean ± standard error of mean (SEM). The standard dose (300 mg/kg body weight) was determined based on Hazekawa et al. [37]. More detailed methodology can be found in Suruga et al. [9].
3.2 Stimulation of NGF synthesis by H. ramosum and H. erinaceum mycelia
The effects of 14-days of oral administration of 300 mg/kg H. erinaceum mycelia and H. ramosum mycelia on NGF levels in intact mouse brains are shown in Figure 4. H. ramosum mycelia were more potent than H. erinaceum mycelia in terms of NGF stimulation in the hippocampus of intact mice. Processing of H. ramosum mycelia over time significantly increased NGF levels in the hippocampus.
Figure 4.
Activation of NGF synthesis with wild H. erinaceum and H. ramosum mycelia [9]. NGF levels in various parts of the brain were measured after 14 days of repeated oral administration of H. erinaceum and H. ramosum mycelia (300 mg/kg). 1, Cortex; 2, striatum; and 3, hippocampus. Data are expressed as the mean ± SEM. *p < 0.05, compared with vehicle (Student’s test).
Different regions of the mouse brain responded differently to application of varying concentrations of H. ramosum mycelia on NGF synthesis [9]. The NGF levels in hippocampus increased with increased concentration of H. ramosum mycelia, while such dose-dependent response was not seen in cortex or striatum (Figure 5).
Figure 5.
Effect of varying concentrations of wild H. ramosum mycelia on NGF synthesis in different parts of mouse brain [9]. 1, Cortex; 2, striatum; and 3, hippocampus. Data are expressed as the mean ± SEM. *p < 0.05 and **p < 0.01, compared with vehicle (Student’s test).
4. Soybean fermentation using mushroom mycelia
The legume soybean is highly proteinaceous (36% protein in dried beans), rich in major nutrients essential for human nutrition and can potentially be a good replacement for animal-derived proteins [38, 39, 40, 41]. It can be used both in fermented and non-fermented forms [42]. While soybeans are rich in flavonoid groups such as genistein, daidzein, and glycitein isoflavones that have tremendous health benefits [43], they are not easily absorbed and incorporated in their natural glycosylated forms unless hydrolyzed by the microflora of the intestine through their beta-glucosidase production [44]. Isoflavones have health benefits against several diseases and hormone-related issues [45, 46, 47, 48]. The easily absorbable form of flavones is the aglycon form, which is abundant in fermented sources of soybean, such as tempeh, miso, and natto [49].
Mushroom mycelia can be used as a source of beta glucosidase to convert isoflavone glycosides to their aglycon form. For example, G. lusidum, belonging to the basidiomycetes group, has been shown to increase serum concentration of the aglycon form of isoflavones in soybeans [50].
Studies from our laboratory investigated the health effects of fermentation using mushrooms, such as G. lucidum, H. erinaceum, and H. ramosum [10]. We measured DPPH scavenging activity, total phenolic content, antioxidant activity, alpha glucosidase inhibition, and isoflavone concentration, few major health parameters of paramount importance, in soybeans fermented with different mushroom types and compared them with non-fermented soybeans.
Soybean fermentation was carried out as described in Suruga et al. [10]. We found that G. lucidum was more effective in quickly fermenting soybeans compared to the other two mushroom types (Figure 6).
Figure 6.
G. lucidum was faster in fermenting soybeans compared to other types (a) Control (non-fermented soybeans); (b) G. lucidum; (c) H. erinaceum; (d) H. ramosum [10].
4.1 Antioxidant activity of fermented soybean
4.1.1 Methods
The DPPH radical scavenging activity and total phenolic content of fermented soybeans were analyzed using the methods described in Subsections 2.3.1 and 2.4.1. Oxygen radical absorbance capacity (ORAC) was determined using the OxiSelect™ ORAC Activity Assay Kit (Cell Biolabs Inc., San Diego, CA, USA) [51]. The assay was performed as described in Suruga et al. [10]. Briefly, fluorescence activity of the reaction mixture with antioxidant and fluorescein solution was measured after adding the free radical initiator. Increasing Trolox concentrations were used for the standard curve, and extracts were quantified and expressed as μmol Trolox equivalents/g of dry fermented soybean powder.
4.1.2 Total phenolic content and antioxidant activity of fermented soybean by mushroom mycelia
Total phenolic content was higher in all the fermented extracts compared to non-fermented control soybeans. Both DPPH radical scavenging activity and antioxidant activity were higher in fermented soybeans than in non-fermented ones (Table 1).
Total phenolic content and antioxidant activity of soybeans fermented by mushroom mycelia [10].
4.2 Alpha-glucosidase inhibitory activity of soybeans fermented with mushroom mycelia
4.2.1 Methods
Yeast alpha-glucosidase inhibitory activity was measured using methods reported before [52] with modifications as described in Suruga et al. [10]. Briefly, yeast alpha-glucosidase was incubated with fermented soybean extract solutions and then p-nitrophenyl α-D-glucopyranoside (pNP-glucoside) was added and absorbance was determined at 400 nm. For the mammalian reaction, alpha glucosidase from rat intestinal acetone powder [53] was incubated with fermented soybean extract and the amount of glucose released was measured. We also used maltose as the substrate and calculated the % inhibition rate of alpha glucosidase [54].
4.2.2 Fermented soybean showed higher inhibition of alpha-glucosidase activity compared to non-fermented ones
Comparison of control (non-fermented soybeans) to soybeans fermented with mushroom mycelia showed that significant alpha-glucosidase inhibition could be achieved in the fermented soybeans using both pNP-glucoside and maltose (Figure 7A and B). Yeast alpha-glucosidase inhibition was the highest with H. ramosum compared to G. lucidum and H. erinaceum, while the mammalian alpha-glucosidase inhibition was significantly higher with G. lucidum fermentation (Figure 7A–C).
Figure 7.
Inhibition of alpha-glucosidase activity soybeans fermented by mushroom mycelia. (A) Yeast alpha-glucosidase inhibition using pNP-glucoside as substrate, (B) mammalian alpha-glucosidase inhibition using maltose as substrate, and (C) mammalian alpha-glucosidase inhibition using sucrose as substrate. Results are expressed as mean ± SD (n = 3). N.D.: not detectable. 1: p < 0.01 vs. control, 2: p < 0.01 vs. G. lucidum, 3: p < 0.01 vs. H. erinaceum, 4: p < 0.01 vs. H. ramosum, and 5: p < 0.05 vs. H. ramosum [10].
4.3 Comparison of isoflavone concentrations in soybeans fermented with mycelia versus non-fermented soybeans
We followed the methods described in Kudou et al. [55] for measuring isoflavone concentrations in fermented and non-fermented soybeans. An LC-6A system (Shimadzu, Kyoto, Japan) equipped with a PEGASIL-ODS (4.6 mm i.d. × 250 mm) HPLC column (Senshu Scientific, Tokyo, Japan) was used for analysis. HPLC parameters used for the measurement of different isoflavones, such as genistein, daidzein, glycitein, daidzin, and glycitin, both in the glycosylated and in aglycone forms, are detailed in Suruga et al. [10].
An ACQUITY UPLC apparatus (Waters MS Technologies, Manchester, UK) equipped with a reversed-phase Acquity UPLC CHS C18 column with a particle size of 2.1 mm × 100 mm × 1.7 μm (Waters MS Technologies) was used for LC/MS analysis. Parameters of analysis are documented in detail in Suruga et al. [10].
4.3.3 Fermentation with mushrooms decreased the concentrations of glycosylated forms of isoflavones and increased the concentrations of aglycon forms
LC/MS profile was shown in Figure 8. The concentration of glycosylated forms of isoflavones, such as daidzin, glycitin, and genistin was about 95.6% in non-fermented soybeans, while it was reduced to 52.5, 15.8, and 17.6% in soybeans fermented by the G. lucidum, H. erinaceum, and H. ramosum mycelia, respectively. The aglycone forms of these isoflavones, on the other hand, increased from 4.4% in the non-fermented controls to 47.5, 84.2, and 82.4% in soybeans fermented by G. lucidum, H. erinaceum, and H. ramosum mycelia, respectively. LC/MS profile shown in Figure 8 corroborate these results. Based on the retention time and MS data, molecular formula and identity of compounds corresponding to 11 of the 12 peaks have been predicted: peak #1, daidzin; peak #2, glycitin; peak #3, 8-hydroxydaidzein; peak #4, genistin; peak #5, 6″-O-malonyldaidzin; peak #7, 6″-O-acetyldaidzin; peak #8, 6″-O-malonylgenistin; peak #9, daidzein; peak #10, glycitein; peak #11, 6″-O-acetylgenistin; and peak #12, genistein, respectively.
Figure 8.
LC/MS profile of soybean fermented using mushroom mycelia: a, control (non-fermented soybeans); b, G. lucidum; c, H. erinaceum; and d, H. ramosum [10].
5. Discussion
5.1 Characteristics of H. ramosum mycelia and other mushroom mycelia
While the beneficial effects of mushrooms in human health and nutrition have long been known and their pharmacological use has been studied in several types of mushrooms, including Pleurotus, Ganoderma, Cordyceps, Lentinus, Grifola, and Hericium [56], there are plenty of rare species of mushrooms that have not been investigated yet in terms of their biological functions, such as antioxidant activity, induction of NGF synthesis, etc. For example, there is only a single report that investigated the kappa opioid receptor binding activity of erinacine E on H. ramosum, indicating the rarity of this mushroom. Our analysis has provided a vast amount of data on the potential value of this mushroom. Given their vast health benefits and medicinal value, finding new mushrooms and analyzing their biological and pharmacological properties is of tremendous importance toward utilizing them in the development of new drugs and food supplements. We have investigated 20 mushroom types for their health benefits.
DPPH radical scavenging activity is a good indicator of antioxidant properties. Our study indicated that several mushrooms (L. shimeji #19, G. frondosa #10, H. erinaceum #5, and H. ramosum #6) were potent scavengers of DPPH (Figure 1). We also found a direct correlation (R2 = 0.7929) between total phenolic content and DPPH radical scavenging activity (Figure 3). A direct relationship between total phenolic content and DPPH scavenging activity has been demonstrated in several studies. For example, a direct correlation (R2 = 0.9788) between total phenolic content and total antioxidant activity has been shown in 11 kinds of fruits by Sun et al. [58]. A direct relationship (R2 = 0.8181) between total phenolics volume and DPPH radical scavenging activity has also been reported in the fruiting bodies of 14 different kinds of commercially available mushrooms by Abdullah et al. [59]. A direct relationship was reported between the high antioxidant activity observed in rice fermented by Monascus mycelia and its high total phenolic compound levels [60]. Our results corroborate the findings from these reports.
From our analyses, we have found that L. shimeji (#19) and G. frondosa (#10) had potent DPPH radical-scavenging activities. Several studies have investigated the applications of these and other mushrooms in various diseases and for other purposes. Pyranose oxidase, a flavoprotein from L. shimeji (Honshimeji in Japanese), has been studied and its heterologous expression is reported to be under the control of the T7 promoter in Escherichia coli [61]. L. connatum fruiting bodies (Oshiroishimeji) have been shown to contain new ceramides [62]. The antitumor activities of (1 → 3)-ß-D-glucan and (1 → 6)-ß-D-glucan from L. decastes (Hatakeshimeji) hot water extract against Sarcoma 180 have also been described [63].
Several compounds responsible for DPPH and antioxidant activity have been isolated from mushrooms and studied in detail. However, little information has been published regarding the DPPH scavenging activity of active compounds from mycelia of L. shimeji and G. frondosa. DPPH active compounds ergothioneine, N-hydroxy-N′,N′-dimethylurea, connatin, and ß-hydroxyergothioneine have been isolated from L. connatum fruiting bodies [64]. Yeh et al. described the antioxidant compounds β-tocopherol and flavonoids in ethanol extracts of G. frondosa fruiting bodies, which are edible mushrooms in Japan [65]. Zhang et al. isolated three analogues of ergosterol from G. frondosa mycelia as compounds with antioxidant activity [66]. Reis et al. investigated the effects of five kinds of mushroom mycelia (A. bisporus-white, A. bisporus-brown, P. ostreatus, P. eryngii, and L. edodes) on antioxidant activity. The authors reported that the antioxidant compounds of these mushroom mycelia were gallic acid, protocatechuic acid, p-hydroxybenzoic acid, and p-coumaric acid [67]. Considering these observations, the potent DPPH scavenging activity of L. shimeji, G. frondosa, and other mushrooms could be attributed to the polyphenols ergothioneine, N-hydroxy-N′,N′-dimethylurea, connatin, ß-hydroxyergothioneine ergosterol, α-tocopherol, flavonoids, gallic acid, protocatechuic acid, p-hydroxybenzoic acid, and p-coumaric acid.
The present findings indicate that the DPPH radical scavenging activity of the Hericiaceae group, including H. erinaceum (#5) and H. ramosum (#6), was stronger than those of other mushroom mycelia. The antioxidant activity of some phenolic compounds has been reported in the H. erinaceum and its mycelial extracts [68]. A strong antioxidant activity has also been shown in vitro in polysaccharides derived from an ethanol extract of H. erinaceum grown on tofu [69]. Thus, there has been minimal effect on H. ramosum mycelia which contain phenolic compounds and polysaccharides with strong antioxidant activity.
NGF plays a crucial role in nerve growth and neuronal cell function, and protection of neurons. NGF has been implicated in various diseases, including in Alzheimer’s disease, the most common type of dementia that affects language, memory, processing of visual cues, judgment, and mood [70]. Reduced levels of NGF or increased accumulation of β-amyloid peptide and tau protein have been suggested as causes of AD [71]. Given its importance, there has been a demand for finding natural inducers of NGF synthesis. Natural compounds such as hericenones and erinacines isolated from H. erinaceum have been shown to induce NGF synthesis [33, 72]. We have shown that H. ramosum mycelia induced stronger NGF synthesis activity compared to H. erinaceum mycelia in the hippocampus of intact mice, and that processing of H. ramosum mycelia over time elevated the levels of NGF levels (Figure 4). We also found a dose-dependent response of NGF with increasing concentrations of H. ramosum mycelia in the hippocampi of intact mice (Figure 5). However, we have not determined the active compounds in the mycelia responsible for NGF synthesis. There are mounting evidence suggesting that erinacine species could be responsible, with the isolation of erinacine E from H. ramosum [57], and the observation that active substances other than hericenones stimulated NGF synthesis through c-Jun N-terminal kinase activation in H. erinaceum [73]. This evidence indicates that erinacine species could be involved in the induction of NGF synthesis in H. ramosum mycelia. There may be involvement from other unknown compounds as well, as our data comes from mycelia and not the fruiting bodies.
5.2 Soybean fermentation of mushroom mycelia
Mushrooms are effective in combating issues caused by obesity, diabetes, and other health issues [74]. The medicinal value of mushrooms has been known for thousands of years [75, 76] and they have been incorporated in nutrition supplements [74] and in the production of fermented foods, such as soybean-based foods, bread and cheese, and in alcoholic beverages [77]. However, detailed analysis of soybeans fermented by mushroom mycelia has not been conducted, insofar as their oxidative properties or alpha-glucosidase inhibitory activity are concerned. Our study analyzed all these properties and the LC/MS profiles of the bioactive products to glean more insights into the medicinal value of fermented soybeans.
We found that soybeans fermented with mushroom mycelia had stronger DPPH radical scavenging activity and ORAC than the non-fermented control ones. We also found that H. ramosum mycelia were more potent in DPPH radical scavenging and oxygen radical absorbance compared to all the other 19 mushroom groups we had tested (Figure 1) [9]. While this result was consistent in our subsequent study, we also found that DPPH radical scavenging activity and total phenolic content of G. lucidum mycelia-fermented soybeans was higher than soybeans fermented with H. erinaceum and H. ramosum mycelia [10].
The compound 8-hydroxydaidzein (peak #3 in Figure 8b) and one unidentified compound (peak #6) were identified by LC/MS analysis in soybeans fermented using G. lucidum mycelia. While we are investigating the identity of this unknown compound, we believe that this could possibly be 6-hydroxydaidzein or 3-hydroxydaidzein based on mass spectrometry analysis results. 6-Hydroxydaidzein has been isolated from soybean koji fermented with Aspergillus oryzae [78] and was found to be more potent in terms of antioxidative properties compared to daidzein [79], suggesting that phenolic compounds such as hydroxydaidzeins could influence the antioxidant effects of soybeans fermented with G. lucidum mycelia. Since oxidative stress is linked to several diseases [80], mushroom mycelia showing antioxidant activity is of much relevance toward producing antioxidant foods and nutritional supplements. We have shown high antioxidant activity in G. lucidum mycelia-fermented soybeans [10], as well as in fermented soy residue (“okara”) with Rhizopus oligosporus [81, 82, 83].
Alpha-glucosidases are the primary enzymes responsible for hydrolyzing carbohydrates into glucose. Inhibition of alpha-glucosidase activity, therefore, is a strategy for controlling increase in blood glucose levels in diabetic conditions. We have shown that soybeans fermented with mushroom mycelia have significantly higher alpha-glucosidase activity than the non-fermented control groups. When pNP-glucoside was used as a substrate, the yeast alpha-glucosidase activity was inhibited in soybeans fermented with H. erinaceum, H. ramosum, and G. lucidum mycelia, with fermentation using the Hericiaceae members showing higher inhibition than with G. lucidum mycelia. Similar inhibition of alpha-glucosidase using pNP-glucoside has been achieved by the commercial soy isoflavone genistein by Lee et al. [84], suggesting that genistein might play a role. Despite pNP-glucoside’s wide usage in testing anti-diabetic agents, maltose and sucrose are biologically more relevant as substrates than pNP-glucoside for mammalian systems. Therefore, we used these two substrates for testing inhibition of alpha-glucosidase activity in soybeans fermented using H. erinaceum, H. ramosum, and G. lucidum mycelia. We found that all three were able to inhibit alpha-glucosidase activity with varying degrees, with G. lucidum mycelia exhibiting higher inhibition with both maltose and sucrose as substrates compared to the other mushroom species. We suspect that in addition to genistein, hydroxydaidzein in soybeans fermented using G. lucidum mycelia could facilitate this inhibition. The precise identification of the active compounds in fermented soybeans using mushroom mycelia is yet to be completed, but fermented soybeans have potential use as nutritional supplements for treating diabetes.
The beta-glucosidase enzyme (EC 3.2.1.21) produced by microbes facilitates the breakdown of glycosylated isoflavones to their aglycon form, which is more easily absorbable [85]. Several microbes, including Aspergillus niger [86], A. oryzae [87], Penicillium brasilianum [88], and Phanerochaete chrysosporium [89], are being tapped for this fermentation purpose. We found that the levels of aglycons (daidzein, glycitein, and genistein), were higher in soybeans fermented with mycelia compared to non-fermented soybeans. While one previous report has shown the conversion of isoflavone glucosides to aglycons using G. lucidum mycelia to ferment soybeans [50], not many studies have investigated soybean fermentation using H. erinaceum and H. ramosum mycelia. We have shown that fermentation using these mycelia increased the amount of the aglycon form compared to non-fermented ones. The amount of aglycons was higher with H. erinaceum and H. ramosum mycelia compared to that when G. lucidum mycelia were used, possibly because the former produces more beta-glucosidase enzyme than the latter.
Our mass spectrometry analysis data revealed that the aglycon form of isoflavones obtained in soybeans fermented with G. lucidum mycelia contained 8-hydroxydaidzein and an unidentified compound, which we assumed to be 6-hydroxydaidzein or 3-hydroxydaidzein based on m/z data and molecular formula derived from LC/MS analysis. 8-Hydroxydaidzein was first isolated from Streptomyces sp. fermentation broth [90] and has also been obtained from A. oryzae and recombinant Pichia pastoris, in addition to 6-hydroxydaidzein and 3-hydroxydaidzein [91]. This compound has been shown to have anti-proliferative, tyrosinase inhibition, aldose reductase inhibition, anti-inflammatory, and antioxidant activities [79, 92, 93, 94, 95], indicating that soybeans fermented with G. lucidum mycelia might also have these properties. Since the mechanism of conversion of hydroxydaidzein to daidzin is known [96], and given its valuable properties, synthetic hydroxydaidzein is produced at the commercial level, but the process has its own limitations, such as the formation of undesirable by-products, lengthy reaction steps and low yield [97]. Large-scale production of hydroxydaidzein using natural resources such as A. oryzae are being investigated [96, 98]. Our results have added several suitable candidates for this purpose. In particular, soybeans fermented using G. lucidum mycelia have enormous potential to be used as food, nutritional supplement and as a source for commercial production of hydroxydaidzein.
Acknowledgments
We are grateful to the Chairman and CEO Masahito Hoashi, Kibun Foods Inc., for his support of this study.
Conflict of interest
The authors declare that there are no conflicts of interest.
\n',keywords:"H. ramosum mycelia, antioxidant, NGF synthesis, soybean fermentation, isoflavone",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/80675.pdf",chapterXML:"https://mts.intechopen.com/source/xml/80675.xml",downloadPdfUrl:"/chapter/pdf-download/80675",previewPdfUrl:"/chapter/pdf-preview/80675",totalDownloads:38,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 29th 2021",dateReviewed:"January 7th 2022",datePrePublished:"April 12th 2022",datePublished:null,dateFinished:"March 2nd 2022",readingETA:"0",abstract:"The medicinal value of mushrooms is long known, but there is increasing awareness of their health benefits and interest in utilizing these in diet as food or nutritional supplement. In this chapter, we discuss the characteristics of 20 wild mushrooms and results from our work on their antioxidant activity, ability to promote nerve growth factor (NGF) synthesis and to convert the glycosylated forms of isoflavones to usable aglycon forms in soybeans fermented with their mycelia. Of the 20 mushroom types, we found that Hericium ramosum (H. ramosum) mycelia had higher antioxidant activity and showed greater capability for increasing the levels of aglycons, such as daidzein, glycitein, and genistein when used for fermentation of soybeans. In general, soybeans fermented with mushrooms increased the levels of aglycons compared to non-fermented ones. Taken together, all these results suggest that mushroom mycelia have a huge potential to be used as food and nutritional supplements for the health benefits they offer and present the prospects for utilizing them in soybean fermentation as natural resources for the large-scale production of aglycons.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/80675",risUrl:"/chapter/ris/80675",signatures:"Kohei Suruga, Tsuyoshi Tomita and Kazunari Kadokura",book:{id:"11363",type:"book",title:"Functional Food",subtitle:null,fullTitle:"Functional Food",slug:null,publishedDate:null,bookSignature:"Dr. Naofumi Shiomi and Ph.D. Anna Savitskaya",coverURL:"https://cdn.intechopen.com/books/images_new/11363.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-793-9",printIsbn:"978-1-80355-792-2",pdfIsbn:"978-1-80355-794-6",isAvailableForWebshopOrdering:!0,editors:[{id:"163777",title:"Dr.",name:"Naofumi",middleName:null,surname:"Shiomi",slug:"naofumi-shiomi",fullName:"Naofumi Shiomi"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Characteristics of wild mushroom mycelia",level:"1"},{id:"sec_2_2",title:"2.1 Collection of mushrooms and separation of mycelia",level:"2"},{id:"sec_3_2",title:"2.2 Ethanol extract preparation from mushroom mycelia",level:"2"},{id:"sec_4_2",title:"2.3 Antioxidant activity of wild mushroom mycelia",level:"2"},{id:"sec_4_3",title:"2.3.1 Methods",level:"3"},{id:"sec_5_3",title:"2.3.2 DPPH free radical scavenging activity of mushroom mycelia",level:"3"},{id:"sec_7_2",title:"2.4 Total phenolic content of the wild mushroom mycelia",level:"2"},{id:"sec_7_3",title:"2.4.1 Methods",level:"3"},{id:"sec_8_3",title:"2.4.2 Measurement of total phenolic content",level:"3"},{id:"sec_10_2",title:"2.5 Phenolic compounds enable the DPPH radical scavenging capacity of mushroom mycelia",level:"2"},{id:"sec_12",title:"3. NGF synthesis of H. ramosum mycelia",level:"1"},{id:"sec_12_2",title:"3.1 Methods",level:"2"},{id:"sec_13_2",title:"3.2 Stimulation of NGF synthesis by H. ramosum and H. erinaceum mycelia",level:"2"},{id:"sec_15",title:"4. Soybean fermentation using mushroom mycelia",level:"1"},{id:"sec_15_2",title:"4.1 Antioxidant activity of fermented soybean",level:"2"},{id:"sec_15_3",title:"4.1.1 Methods",level:"3"},{id:"sec_16_3",title:"Table 1.",level:"3"},{id:"sec_18_2",title:"4.2 Alpha-glucosidase inhibitory activity of soybeans fermented with mushroom mycelia",level:"2"},{id:"sec_18_3",title:"4.2.1 Methods",level:"3"},{id:"sec_19_3",title:"4.2.2 Fermented soybean showed higher inhibition of alpha-glucosidase activity compared to non-fermented ones",level:"3"},{id:"sec_21_2",title:"4.3 Comparison of isoflavone concentrations in soybeans fermented with mycelia versus non-fermented soybeans",level:"2"},{id:"sec_21_3",title:"4.3.1 Methods: high-performance liquid chromatography (HPLC) analysis",level:"3"},{id:"sec_22_3",title:"4.3.2 Methods: liquid chromatography/mass spectrometry (LC/MS) analysis",level:"3"},{id:"sec_23_3",title:"4.3.3 Fermentation with mushrooms decreased the concentrations of glycosylated forms of isoflavones and increased the concentrations of aglycon forms",level:"3"},{id:"sec_26",title:"5. Discussion",level:"1"},{id:"sec_26_2",title:"5.1 Characteristics of H. ramosum mycelia and other mushroom mycelia",level:"2"},{id:"sec_27_2",title:"5.2 Soybean fermentation of mushroom mycelia",level:"2"},{id:"sec_29",title:"Acknowledgments",level:"1"},{id:"sec_32",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Wang Q, Wang F, Xu Z, Ding Z. Bioactive mushroom polysaccharides: A review on monosaccharide composition, biosynthesis and regulation. Molecules. 2017;22:955. DOI: 10.3390/molecules22060955'},{id:"B2",body:'Yang Y, He P, Li N. The antitumor potential of extract of the oak bracket medicinal mushroom Inonotus baumii in SMMC-7721 tumor cells. Evidence-based Complementary and Alternative Medicine. 2019;2019:1242784. DOI: 10.1155/2019/1242784'},{id:"B3",body:'Yang NC, Wu CC, Liu RH, Chai YC, Tseng CY. Comparing the functional components, SOD-like activities, antimutagenicity, and nutrient compositions of Phellinus igniarius and Phellinus linteus mushrooms. Journal of Food and Drug Analysis. 2016;24:343-349. DOI: 10.1016/j.jfda.2015.11.007'},{id:"B4",body:'Ellan K, Thayan R, Raman J, Hidari KIPJ, Ismail N, Sabaratnam V. Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: An in-vitro study. BMC Complementary and Alternative Medicine. 2019;19:260. DOI: 10.1186/s12906-019-2629-y'},{id:"B5",body:'Fontes A, Alemany-Pagès M, Oliveira PJ, Ramalho-Santos J, Zischka H, Azul AM. Antioxidant versus pro-apoptotic effects of mushroom-enriched diets on mitochondria in liver disease. International Journal of Molecular Sciences. 2019;20:3987. DOI: 10.3390/ijms20163987'},{id:"B6",body:'Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biological & Pharmaceutical Bulletin. 2008;31:1727-1732. DOI: 10.1248/bpb.31.1727'},{id:"B7",body:'Kimura T, Yamamoto K, Nishikawa Y. Comparison of the antitumor effect of the fruit body and mycelia of Hanabiratake (Sparassis crispa). Mushroom Science and Biotechnology. 2013;21:129-132. DOI: 10.24465/msb.213_129'},{id:"B8",body:'Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, et al. Neurohealth properties of Hericium erinaceus mycelia enriched with erinacines. Behavioural Neurology. 2018;2018:5802634. DOI: 10.1155/20185802634'},{id:"B9",body:'Suruga K, Kadokura K, Sekino Y, Nakano T, Matsuo K, Irie K, et al. Effects of comb tooth cap medicinal mushroom, Hericium ramosum (Higher Basidiomycetes) mycelia on DPPH radical scavenging activity and nerve growth factor synthesis. International Journal of Medicinal Mushrooms. 2015;17:331-338. DOI: 10.1615/imtjmedmushrooms.v17.i4.20'},{id:"B10",body:'Suruga K, Tomita T, Kadokura K. Soybean fermentation with basidiomycetes (medicinal mushroom mycelia). Chemical and Biological Technologies in Agriculture. 2020;7:23. DOI: 10.1186/s40538-020-00189-1'},{id:"B11",body:'Yoneyama M, Meguro S, Kawachi S. Liquid culture of Agaricus blazei (in Japanese). Mokuzai Gakkaishi. 1997;43:349-355'},{id:"B12",body:'Mizuno M, Morimoto M, Minato K, Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Bioscience, Biotechnology, and Biochemistry. 1998;62:434-437. DOI: 10.1271/bbb.62.434'},{id:"B13",body:'Nakamura T, Matsugo S, Uzuka Y, Matsuo S, Kawagishi H. Fractionation and anti-tumor activity of the mycelia of liquid-cultured Phellinus linteus. Bioscience, Biotechnology, and Biochemistry. 2004;68:868-872. DOI: 10.1271/bbb.68.868'},{id:"B14",body:'Osawa T, Ide A, Su JD, Namiki M. Inhibition of in vitro lipid peroxidation by ellagic acid. Journal of Agricultural and Food Chemistry. 1987;35:808-812. DOI: 10.1021/jf00077a042'},{id:"B15",body:'Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Rosa GD, et al. Oxidative stress in obesity: A critical component in human diseases. International Journal of Molecular Sciences. 2015;16:378-400. DOI: 10.3390/ijms16010378'},{id:"B16",body:'Cutlar RG. Genetic stability and oxidative stress: Common mechanisms in aging and cancer. In: Emerit I, Chance B, editors. Free Radicals and Aging. Basel: Birkhäuser; 1992. pp. 31-46'},{id:"B17",body:'Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, et al. Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Archives of Biochemistry and Biophysics. 2015;576:39-48. DOI: 10.1016/j.abb.2014.12.018'},{id:"B18",body:'Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 2nd ed. Oxford: Clarendon Press; 1989. pp. 20-30'},{id:"B19",body:'Peng X, Gao Q, Zhou J, Ma J, Zhao D, Hao L. Association between dietary antioxidant vitamins intake and homocysteine levels in middle-aged and older adults with hypertension: A cross-sectional study. BMJ Open. 2021;11:e045732. DOI: 10.1136/bmjopen-2020-045732'},{id:"B20",body:'Midoh N, Tanaka A, Nagayasu M, Furuta C, Suzuki K, Ichikawa T, et al. Antioxidative activities of oxindole-3-acetic acid derivatives from supersweet corn powder. Bioscience, Biotechnology, and Biochemistry. 2010;74:1794-1801. DOI: 10.1271/bbb.100124'},{id:"B21",body:'Shahidi F, Yao JD. Insoluble-bound phenolics in food. Molecules. 2016;21:1216. DOI: 10.3390/molecules21091216'},{id:"B22",body:'Eskin NA, Ho CT, Shahidi F. Browning reactions in foods. In: Eskin NAM, Shahidi F, editors. Biochemistry of Foods. 3rd ed. Cambridge, MA, USA: Academic Press; 2012. pp. 245-289'},{id:"B23",body:'Osakabe N, Yasuda A, Natsume M, Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: Anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis. 2004;25:549-557. DOI: 10.1093/carcin/bgh034'},{id:"B24",body:'Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods in Enzymology. 1999;299:152-178'},{id:"B25",body:'Collerton D. Cholinergic function and intellectual decline in Alzheimer’s disease. Neuroscience. 1986;19:1-28. DOI: 10.1016/0306-4522(86)90002-3'},{id:"B26",body:'Obara Y, Nakahata N. The signaling pathway of neurotrophic factor biosynthesis. Drug News & Perspectives. 2002;15:290-298. DOI: 10.1358/dnp.2002.15.5.840042'},{id:"B27",body:'Allen SJ, Dawbarn D. Clinical relevance of the neurotrophins and their receptors. Clinical Science (London). 2006;110:175-191. DOI: 10.1042/CS20050161'},{id:"B28",body:'Kromer LF. Nerve growth factor treatment after brain injury prevents neuronal death. Science. 1987;235:214-216. DOI: 10.1126/science.3798108'},{id:"B29",body:'Furukawa Y, Furukawa S, Ikeda F, Satoyoshi E, Hayasghi K. Aliphatic side chain of catecholamine potentiates the stimulatory effect of the catechol part on the synthesis of nerve growth factor. FEBS Letters. 1986;208:258-262. DOI: 10.1016/0014-5793(86)81028-6'},{id:"B30",body:'Tekauchi R, Murase K, Furukawa Y, Furukawa S, Hayashi K. Stimulation of nerve growth factor synthesis/secretion by 1,4-benzoquinone and its derivatives in cultured mouse astroglial cells. FEBS Letters. 1990;261:63-66. DOI: 10.1016/0014-5793(90)80637-x'},{id:"B31",body:'Obara Y, Nakahata N, Kita T, Takaya Y, Kobayashi H, Hosoi S, et al. Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. European Journal of Pharmacology. 1999;370:79-84. DOI: 10.1016/s0014-2999(99)00077-1'},{id:"B32",body:'Kawagishi H, Shimada A, Hosokawa S, Mori H, Sakamoto H, Ishiguro Y, et al. Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Letters. 1996;37:7399-7402. DOI: 10.1016/0040-4036(96)01687-5'},{id:"B33",body:'Kawagishi H, Ando M, Shinba K, Sakamoto H, Yoshida S, Ojima F, et al. Chromans, hericenones F, G and H from the mushroom Hericium erinaceum. Phytochemistry. 1992;32:175-178. DOI: 10.1016/0031-9422(92)80127-Z'},{id:"B34",body:'Kawagishi H, Shimada A, Shirai R, Okamoto K, Ojima F, Sakamoto H, et al. Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Letters. 1994;35:1569-1572. DOI: 10.1016/S0040-4039(00)76760-8'},{id:"B35",body:'Kawagishi H, Ando M, Mizuno T. Hericenone A and B as cytotoxic principles from the mushroom Hericium erinaceum. Tetrahedron Letters. 1990;31:373-376. DOI: 10.1016/S0040-4039(00)94558-1'},{id:"B36",body:'Lee EW, Shizuki K, Hosokawa S, Suzuki M, Suganuma H, Inakuma T, et al. Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum. Bioscience, Biotechnology, and Biochemistry. 2000;64:2402-2405. DOI: 10.1271/bbb.64.2402'},{id:"B37",body:'Hazekawa M, Kataoka A, Hayakawa K, Uchimasu T, Furuta R, Irie K, et al. Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion. Journal of Health Science. 2010;56:296-303. DOI: 10.1248/jhs.56.296'},{id:"B38",body:'Bahuguna A, Shukla S, Lee JS, Bajpai VK, Kim SY, Huh YS, et al. Garlic augments the functional and nutritional behavior of Doenjang, a traditional Korean fermented soybean paste. Scientific Reports. 2019;9:5436. DOI: 10.1038/s41598-019-41691-3'},{id:"B39",body:'Liu KS. Chemistry and nutritional value of soybean components. In: Soybeans, Chemistry, Technology, and Utilization. New York, USA: Chapman & Hall; 1997. pp. 25-113'},{id:"B40",body:'Derbyshire E, Wright DJ, Boulter D. Legumin and vicilin, storage proteins of legume seeds. Phytochemistry. 1976;15:3-24. DOI: 10.1016/S0031-9422(00)89046-9'},{id:"B41",body:'Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M. Soy protein, isoflavones, and cardiovascular health: An American heart association science advisory for professionals from the nutrition committee. Circulation. 2006;113:1034-1044. DOI: 10.1161/CIRCULATIONAHA.106.171052'},{id:"B42",body:'Kwon YS, Lee S, Lee SH, Kim HJ, Lee CH. Comparative evaluation of six traditional fermented soybean products in East Asia: A metabolomics approach. Metabolites. 2019;9:183. DOI: 10.3390/metabo9090183'},{id:"B43",body:'Křížová L, Dadáková K, Kašparovská J, Kašparovskŷ T. Isoflavones. Molecules. 2019;24:1076. DOI: 10.3390/molecules24061076'},{id:"B44",body:'Friend DR, Change GW. A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria. Journal of Medicinal Chemistry. 1984;27:261-266. DOI: 10.1021/jm00369a005'},{id:"B45",body:'Messina M, Kucuk O, Lampe JW. An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. Journal of AOAC International. 2006;89:1121-1134'},{id:"B46",body:'Carroll KK. Review of clinical studies on cholesterol-lowering response to soy protein. Journal of the American Dietetic Association. 1991;91:820-827'},{id:"B47",body:'Ye YB, Tang XY, Verbruggen MA, Su YX. Soy isoflavones attenuate bone loss in early postmenopausal Chinese women: A single-blind randomized, placebo-controlled trial. European Journal of Nutrition. 2006;45:327-334. DOI: 10.1007/s00394-006-0602-2'},{id:"B48",body:'Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews. 2007;17:CD001395. DOI: 10.1002/14651858.CD001395.pub3'},{id:"B49",body:'Walker DE, Axelrod B. Evidence for a single catalytic site on the “β-D-glucosidase-β-D-glactosidase” of almond emulsin. Archives of Biochemistry and Biophysics. 1978;187:102-107. DOI: 10.1016/0003-9861(78)90011-5'},{id:"B50",body:'Miura T, Yuan L, Sun B, Fujii H, Yoshida M, Wakame K, et al. Isoflavone aglycone produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity. Bioscience, Biotechnology, and Biochemistry. 2002;66:2626-2631. DOI: 10.1271/bbb.66.2626'},{id:"B51",body:'Ou B, Hampsch-Woodill M, Prior RL. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. Journal of Agricultural and Food Chemistry. 2001;49:4619-4626. DOI: 10.1021/jf10586o'},{id:"B52",body:'Matsui T, Yoshimoto C, Osajima K, Oki T, Osajima Y. In vitro survey of α-glucosidase inhibitory food components. Bioscience, Biotechnology, and Biochemistry. 1996;60:2019-2022. DOI: 10.1271/bbb.60.2019'},{id:"B53",body:'Ohta T, Sasaki S, Oohori T, Yoshikawa S, Kurihara H. Alpha-glucosidase inhibitory activity of a 70% methanol extract from ezoishige (Pelvetia babingtonii de Toni) and its effect on the elevation of blood glucose level in rats. Bioscience, Biotechnology, and Biochemistry. 2002;66:1552-1554. DOI: 10.1271/bbb.66.1552'},{id:"B54",body:'Sawada Y, Tsuno T, Ueki T, Yamamoto H, Furukawa Y, Oki T. Pradimicin Q, a new pradimicin aglycone, with α-glucosidase inhibitory activity. The Journal of Antibiotics. 1993;46:507-510. DOI: 10.7164/antibiotics.46.507'},{id:"B55",body:'Kudou S, Fleury Y, Welti D, Magnolato D, Uchida T, Kitamura K, et al. Malonyl isoflavone glycosides in soybean seeds (Glycine max MERRILL). Agricultural and Biological Chemistry. 1991;55:2227-2233. DOI: 10.1271/bbb1961.55.2227'},{id:"B56",body:'Lindequist U, Niedermeyer THJ, Jülish WD. The pharmacological potential of mushrooms. Evidence-based Complementary and Alternative Medicine. 2005;2:285-299. DOI: 10.1093/ecam/neh107'},{id:"B57",body:'Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, et al. Erinacine E as a kappa opioid receptor agonist and its new analogs from a Basidiomycete, Hericium ramosum. The Journal of Antibiotics. 1998;51:983-990. DOI: 10.7164/antibiotics.51.983'},{id:"B58",body:'Sun J, Chu YF, Wu X, Liu RH. Antioxidant and antiproliferative activities of common fruits. Journal of Agricultural and Food Chemistry. 2002;50:7449-7454. DOI: 10.1021/jf0207530'},{id:"B59",body:'Abdullash N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-based Complementary and Alternative Medicine. 2012;2012:464238. DOI: 10.1155/2012/464238'},{id:"B60",body:'Yang JH, Tseng YH, Lee YL, Mau JL. Antioxidant properties of methanolic extracts from monascal rice. LWT- Food Science and Technology. 2006;39:740-747. DOI: 10.1016/j.lwt.2005.06.002'},{id:"B61",body:'Salaheddin C, Takakura Y, Tsunashima M, Stranzinger B, Spadiut O, Yamabjai M, et al. Characterization of recombinant pyranose oxidase from the cultivated mycorrhizal basidiomycete Lyophyllum shimeji (hon-shimeji). Microbial Cell Factories. 2010;9:1-12. DOI: 10.1186/1475-2859-9-57'},{id:"B62",body:'Yaoita Y, Kohata R, Kakuda R, Machida K, Kikuchi M. Ceramide constituents from five mushrooms. Chemical & Pharmaceutical Bulletin. 2002;50:681-684. DOI: 10.1248/cpb.50.681'},{id:"B63",body:'Ukawa Y, Hisamitsu M, Ito H. Antitumor effects of (1→3)-β-D-glucan and (1→6)-β-D-glucan purified from newly cultivated mushroom, Hatakeshimeji (Lyophyllum decastes Sing). Journal of Bioscience and Bioengineering. 2000;90:98-104'},{id:"B64",body:'Barger G, Ewins AJ. CCLVII—The constitution of ergothioneine: A betaine related to histidine. Journal of the Chemical Society, Transactions. 1911;99:2336-2341'},{id:"B65",body:'Yeh JY, Hsieh LH, Wu KT, Tsai CF. Antioxidant properties and antioxidant compounds of various extracts from the edible basidomycete Grifola frondosa (Maitake). Molecules. 2011;16:3197-3211. DOI: 10.3390/molecules16043197'},{id:"B66",body:'Zhang Y, Mills GK, Nair MG. Cyclooxygenase inhibition and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. Journal of Agricultural and Food Chemistry. 2002;50:7581-7585. DOI: 10.1021/jf0257648'},{id:"B67",body:'Reis FS, Martins A, Barros L, Ferreira ICFR. Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: A comparative study between in vivo and in vitro samples. Food and Chemical Toxicology. 2012;50:1201-1207. DOI: 10.1016/jf2012.02.013'},{id:"B68",body:'Khan MA, Tania M, Liu R, Rahman MM. Hericium erinaceus: An edible mushroom with medicinal values. Journal of Complementary and Integrative Medicine. 2013;10:1-6. DOI: 10.1515/jcim-2013-0001'},{id:"B69",body:'Zhang Z, Lv G, Pan H, Pandey A, He W, Fan L. Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey. International Journal of Biological Macromolecules. 2012;51:1140-1146. DOI: 10.1016/j.ijbiomac.2012.09.002'},{id:"B70",body:'Chételat G, Joie RL, Villain N, Perrotin A, Sayette VL, Eustache F, et al. Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer’s disease. NeuroImage: Clinical. 2013;2:356-365. DOI: 10.1016/j.nicl.2012.02.006'},{id:"B71",body:'Kawagishi H, Zhuang C. Compounds for dementia from Hericium erinaceum. Drugs of the Future. 2008;33:149-155. DOI: 10.1358/dof.2008.033.02.1173290'},{id:"B72",body:'Kawagishi H, Ando M, Sakamoto H, Yoshida S, Ojima F, Ishiguro Y, et al. Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum. Tetrahedron Letters. 1991;32:4561-4564. DOI: 10.1016/0040-4039(91)80039-9'},{id:"B73",body:'Kawagishi H, Shimada A, Shizuki K, Ojima F, Mori H, Okamoto K, et al. Erinacines D, a stimulator of NGF-synthesis, from the mycelia of Hericium erinaceum. Heterocyclic Communications. 1996;2:51-54'},{id:"B74",body:'Chaturvedi VK, Agarwal S, Gupta KK, Ramteke PW, Singh MP. Medicinal mushroom: Boon for therapeutic applications. 3 Biotech. 2018;8:334. DOI: 10.1007/s13205-018-1358-0'},{id:"B75",body:'El Enshasy HA, Hatti-Kaul R. Mushroom immunomodulators: Unique molecules with unlimited applications. Trends in Biotechnology. 2013;31:668-677. DOI: 10.1016/j.tibtech.2013.09.003'},{id:"B76",body:'Muszyńska B, Grzywacz-Kisielewska A, Kała K, Gdula-Argasińska J. Anti-inflammatory properties of edible mushrooms: A review. Food Chemistry. 2018;243:373-381. DOI: 10.1016/j.foodchem.2017.09.149'},{id:"B77",body:'Matsui T. Development of functional foods by mushroom fermentation (in Japanese). Mushroom Science and Biotechnology. 2017;24(4):169-175'},{id:"B78",body:'Esaki H, Kawakishi S, Morimitsu Y, Osawa T. New potent antioxidative o-dihydroxyisoflavones in fermented Japanese soybean products. Bioscience, Biotechnology, and Biochemistry. 1999;63:1637-1639. DOI: 10.1271/bbb.63.1637'},{id:"B79",body:'Esaki H, Watanebe R, Onozaki H, Kawakishi S, Osawa T. Formation mechanism for potent antioxidative o-dihydroxyisoflavones in soybean fermented with Aspergillus saitoi. Bioscience, Biotechnology, and Biochemistry. 1999;63:851-858. DOI: 10.1271/bbb.63.851'},{id:"B80",body:'Willcox JK, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Critical Reviews in Food Science and Nutrition. 2004;44:275-295. DOI: 10.1080/10408690490468489'},{id:"B81",body:'Suruga K, Akiyama Y, Kadokura K, Sekino Y, Kawagoe M, Komatsu Y, et al. Synergistic effect on reactive oxygen scavenging activity of fermented okara and banana by XYZ system. Food Science and Technology Research. 2007;13:139-144. DOI: 10.3136/fstr.13.139'},{id:"B82",body:'Suruga K, Kato A, Kadokura K, Hiruma W, Sekino Y, Buffinton CAT, et al. “Okara” a new preparation of food material with antioxidant activity and dietary fiber from soybean. In: El-Shemy H, editor. Soybean and Nutrition. 1st ed. London, UK: IntechOpen; 2011. pp. 311-326. DOI: 10.5772/18821'},{id:"B83",body:'Noguchi S, Suruga K, Nakai K, Murashima A, Koshino-Kimura Y, Kobayashi A. An exploratory study of okara product on postprandial blood glucose and serum insulin responses. The Japanese Journal of Nutrition and Dietetics. 2018;76:156-162. DOI: 10.5264/eiyogakuzashi.76.156'},{id:"B84",body:'Lee DS, Lee SH. Genistein, a soy isoflavone, is a potent α-glucosidase inhibitor. FEBS Letters. 2001;501:84-86. DOI: 10.1016/s0014-5793(01)02631-x'},{id:"B85",body:'Doan DT, Luu DP, Nguyen TD, Thi BH, Thi HMP, Do HN, et al. Isolation of Penicillium citrinum from roots of Clerodendron cyrtophyllum and application in biosynthesis of aglycone isoflavones from soybean waste fermentation. Food. 2019;8:554. DOI: 10.3390/foods8110554'},{id:"B86",body:'Baraldo JA, Borges DG, Tardioli PW, Farinas CS. Characterization of β-glucosidase produced by Aspergillus niger under solid-state fermentation and partially purified using MANAE-agarose. Biotechnology Research International. 2014;2014:317092. DOI: 10.1155/2014/317092'},{id:"B87",body:'Langston J, Sheehy N, Xu F. Substrate specificity of Aspergillus oryze family 3 beta-glucosidase. Biochimica et Biophysica Acta, Proteins and Proteomics. 2006;1764:972-978. DOI: 10.1016/j.bbapap.2006.03.009'},{id:"B88",body:'Krogh KBRM, Harris PV, Olsen CL, Johansen KS, Hojer-Pedersen J, Borjesson J, et al. Characterization and kinetic analysis of a thermostable GH3 beta-glucosidase from Penicillium brasilianum. Applied Microbiology and Biotechnology. 2010;86:143-154. DOI: 10.1007/s00253-009-2181-7'},{id:"B89",body:'Tsukada T, Igarashi K, Yoshida M, Samejima M. Molecular cloning and characterization of two intracellular β-glucosidase belonging to glycoside hydrolase family 1 from the basidiomycete Phanerochaete chrysosporium. Applied Microbiology and Biotechnology. 2006;73:807-814. DOI: 10.1007/s00253-006-0526-z'},{id:"B90",body:'Chang TS, Wang TY, Yang SY, Kao YH, Wu JY, Chiang CM. Potential industrial production of a well-soluble, alkaline-stable, and anti-inflammatory isoflavone glucoside from 8-hydroxydaidzein glucosylated by recombinant amylosucrase of Deinococcus geothermalis. Molecules. 2019;24:2236. DOI: 10.3390/molecules24122236'},{id:"B91",body:'Chiang CM, Ding HY, Tsai YT, Chang TS. Production of two novel methoxy-isoflavones from biotransformation of 8-hydroxydaidzein by recombinant Escherichia coli expressing O-methyltransferase SpOMT2884 from Streptomyces peucetius. International Journal of Molecular Sciences. 2015;16:27816-27823. DOI: 10.3390/ijms161126070'},{id:"B92",body:'Lo YL. A potential daidzein derivative enhances cytotoxicity of epirubicin on human colon adenocarcinoma Caco-2 cells. International Journal of Molecular Sciences. 2013;14:158-176. DOI: 10.3390/ijms14010158'},{id:"B93",body:'Tai SS, Lin CG, Wu MH, Chang TS. Evaluation of depigmenting activity by 8-hydroxydaidzein in mouse B16 melanoma cells and human volunteers. International Journal of Molecular Sciences. 2009;10:4257-4266. DOI: 10.3390/ijms10104257'},{id:"B94",body:'Fujita T, Funako T, Hayashi H. 8-Hydroxydaidzein, an aldose reductase inhibitor from okara fermented with Aspergillus sp. HK-388. Bioscience, Biotechnology, and Biochemistry. 2004;68:1588-1590. DOI: 10.1271/bbb.68.1588'},{id:"B95",body:'Wu PS, Ding HY, Yen JH, Chen SF, Lee KH, Wu MJ. Anti-inflammatory activity of 8-hydroxydaidzein in LPS-stimulated BV2 microglial cells via activation of Nrf2-antioxidant and attenuation of Akt/NF-κB-inflammatory signaling pathways, as well as inhibition of COX-2 activity. Journal of Agricultural and Food Chemistry. 2018;66:5790-5801. DOI: 10.1021/acs.jafc.8b00437'},{id:"B96",body:'Seo MH, Kim BN, Kim KR, Lee KW, Lee CH, Oh DK. Production of 8-hydroxydaidzein from soybean extract by Aspergillus oryzae KACC 40247. Bioscience, Biotechnology, and Biochemistry. 2013;77:1245-1250. DOI: 10.1271/bbb.120899'},{id:"B97",body:'Roh C, Seo SH, Choi KY, Cha M, Pandey BP, Kim JH, et al. Regioselective hydroxylation of isoflavones by Streptomyces avermitilis MA-4680. Journal of Bioscience and Bioengineering. 2009;108:41-46. DOI: 10.1016/j.jbiosc.2009.02.021'},{id:"B98",body:'Wu SC, Chang CW, Lin CW, Hsu YC. Production of 8-hydroxydaidzein polyphenol using biotransformation by Aspergillus oryzae. Food Science and Technology Research. 2015;21:557-562. DOI: 10.3136/fstr.21.557'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Kohei Suruga",address:"kouhei_suruga@kibun.co.jp",affiliation:'
Research and Development Division, Products Development Department, Kibun Foods Inc., Tokyo, Japan
Research and Development Division, Products Development Department, Kibun Foods Inc., Tokyo, Japan
'}],corrections:null},book:{id:"11363",type:"book",title:"Functional Food",subtitle:null,fullTitle:"Functional Food",slug:null,publishedDate:null,bookSignature:"Dr. Naofumi Shiomi and Ph.D. Anna Savitskaya",coverURL:"https://cdn.intechopen.com/books/images_new/11363.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-793-9",printIsbn:"978-1-80355-792-2",pdfIsbn:"978-1-80355-794-6",isAvailableForWebshopOrdering:!0,editors:[{id:"163777",title:"Dr.",name:"Naofumi",middleName:null,surname:"Shiomi",slug:"naofumi-shiomi",fullName:"Naofumi Shiomi"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"101053",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Yamamoto",email:"yamamoto@med.kanazawa-u.ac.jp",fullName:"Hiroshi Yamamoto",slug:"hiroshi-yamamoto",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Kanazawa University",institutionURL:null,country:{name:"Japan"}}},booksEdited:[],chaptersAuthored:[{id:"35639",title:"Significance of Advanced Glycation End-Products (AGE) and the Receptor for AGE (RAGE) in Diabetic Nephropathy",slug:"pathogenesis-of-diabetic-nephropathy-significance-of-advanced-glycation-end-products-age-and-the-rec",abstract:null,signatures:"Tarek Kamal, Yasuhiko Yamamoto and Hiroshi Yamamoto",authors:[{id:"101053",title:"Prof.",name:"Hiroshi",surname:"Yamamoto",fullName:"Hiroshi Yamamoto",slug:"hiroshi-yamamoto",email:"yamamoto@med.kanazawa-u.ac.jp"},{id:"109717",title:"Mr.",name:"Kamal",surname:"Tarek",fullName:"Kamal Tarek",slug:"kamal-tarek",email:"dosouk2000@yahoo.com"},{id:"109718",title:"Dr.",name:"Yasuhiko",surname:"Yamamoto",fullName:"Yasuhiko Yamamoto",slug:"yasuhiko-yamamoto",email:"yasuyama@med.kanazawa-u.ac.jp"}],book:{id:"1429",title:"Diabetic Nephropathy",slug:"diabetic-nephropathy",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"81978",title:"Prof.",name:"Dulce",surname:"Casarini",slug:"dulce-casarini",fullName:"Dulce Casarini",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"101894",title:"Prof.",name:"Mohammad",surname:"Saklayen",slug:"mohammad-saklayen",fullName:"Mohammad Saklayen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wright State University",institutionURL:null,country:{name:"United States of America"}}},{id:"101924",title:"Dr.",name:"John",surname:"Chan",slug:"john-chan",fullName:"John Chan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/101924/images/system/101924.jpg",biography:"Dr. Chan is currently a Professor of Medicine at the Université de Montréal and the Chief of the Laboratory of Molecular Nephrology and Endocrinology at the Research Centre of Centre hospitalier de l’Université de Montréal (CRCHUM). Dr. Chan’s research program seeks to understand the role(s) of intrarenal renin angiotensin system (RAS) and oxidative stress in the pathogenesis of diabetic nephropathy, with special emphasis on renal angiotensinogen gene expression and reactive oxygen species (ROS) generation on tubular apoptosis in diabetes. Dr. Chan has published over 100 papers in scientific journals and presented more than 250 abstracts in various scientific societies. Dr. Chan’s research program is supported by several peer-reviewed granting agencies including the Canadian Institutes of Health Research, Kidney Foundation of Canada, Canadian Diabetes Association and Canadian Foundation of Innovation.",institutionString:null,institution:{name:"University of Montreal",institutionURL:null,country:{name:"Canada"}}},{id:"105224",title:"Prof.",name:"Uh-Hyun",surname:"Kim",slug:"uh-hyun-kim",fullName:"Uh-Hyun Kim",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jeonbuk National University",institutionURL:null,country:{name:"Korea, South"}}},{id:"107429",title:"Dr.",name:"Brice Enid",surname:"Nouthe Tietchou",slug:"brice-enid-nouthe-tietchou",fullName:"Brice Enid Nouthe Tietchou",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Montreal",institutionURL:null,country:{name:"Canada"}}},{id:"107430",title:"Prof.",name:"Shao-Ling",surname:"Zhang",slug:"shao-ling-zhang",fullName:"Shao-Ling Zhang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Montreal",institutionURL:null,country:{name:"Canada"}}},{id:"109717",title:"Mr.",name:"Kamal",surname:"Tarek",slug:"kamal-tarek",fullName:"Kamal Tarek",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kanazawa University",institutionURL:null,country:{name:"Japan"}}},{id:"109718",title:"Dr.",name:"Yasuhiko",surname:"Yamamoto",slug:"yasuhiko-yamamoto",fullName:"Yasuhiko Yamamoto",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kanazawa University",institutionURL:null,country:{name:"Japan"}}},{id:"109732",title:"Dr.",name:"Rozina",surname:"Rani",slug:"rozina-rani",fullName:"Rozina Rani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Chattagram Maa-O-Shishu Hospital Medical College",institutionURL:null,country:{name:"Bangladesh"}}},{id:"110080",title:"Dr.",name:"Maya",surname:"Saleh",slug:"maya-saleh",fullName:"Maya Saleh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"McGill University",institutionURL:null,country:{name:"Canada"}}}]},generic:{page:{slug:"content-alerts",title:"Content alerts",intro:"
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11662},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22333},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33644}],offset:12,limit:12,total:135278},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{amp:"",hasNoEditors:"0",sort:"dateEndThirdStepPublish"},books:[{type:"book",id:"11369",title:"RNA Viruses Infection",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11027",title:"Basics of Hypoglycemia",subtitle:null,isOpenForSubmission:!0,hash:"98ebc1e36d02be82c204b8fd5d24f97a",slug:null,bookSignature:"Dr. Alok Raghav",coverURL:"https://cdn.intechopen.com/books/images_new/11027.jpg",editedByType:null,editors:[{id:"334465",title:"Dr.",name:"Alok",surname:"Raghav",slug:"alok-raghav",fullName:"Alok Raghav"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11124",title:"Next-Generation Textiles",subtitle:null,isOpenForSubmission:!0,hash:"093f9e26bb829b8d414d13626aea1086",slug:null,bookSignature:"Dr. Hassan Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/11124.jpg",editedByType:null,editors:[{id:"90645",title:"Dr.",name:"Hassan",surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11610",title:"New Insights in Herbicide Science",subtitle:null,isOpenForSubmission:!0,hash:"eb3830b8176caf3d1fd52c32313c5168",slug:null,bookSignature:"Ph.D. Kassio Ferreira Mendes",coverURL:"https://cdn.intechopen.com/books/images_new/11610.jpg",editedByType:null,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11561",title:"Zeolite From Wastes - New Perspectives on Innovative Resources and Their Valorization Process",subtitle:null,isOpenForSubmission:!0,hash:"3ed0dfd842de9cd1143212415903e6ad",slug:null,bookSignature:"Dr. Claudia Belviso",coverURL:"https://cdn.intechopen.com/books/images_new/11561.jpg",editedByType:null,editors:[{id:"61457",title:"Dr.",name:"Claudia",surname:"Belviso",slug:"claudia-belviso",fullName:"Claudia Belviso"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11814",title:"Liposomes - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"62d8542d18b8cddcf507f7948b2ae74b",slug:null,bookSignature:"Dr. Rajeev K. Tyagi",coverURL:"https://cdn.intechopen.com/books/images_new/11814.jpg",editedByType:null,editors:[{id:"269120",title:"Dr.",name:"Rajeev",surname:"Tyagi",slug:"rajeev-tyagi",fullName:"Rajeev Tyagi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11778",title:"Correctional Facilities and Correctional Treatment - International Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"a933550a6966a04e4677a4c0aea8f5b2",slug:null,bookSignature:"Prof. Rui Abrunhosa Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11778.jpg",editedByType:null,editors:[{id:"198691",title:"Prof.",name:"Rui",surname:"Abrunhosa Gonçalves",slug:"rui-abrunhosa-goncalves",fullName:"Rui Abrunhosa Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11709",title:"Type 1 Diabetes Mellitus",subtitle:null,isOpenForSubmission:!0,hash:"cc0e61f864a2a8a9595f4975ce301f70",slug:null,bookSignature:"Dr. Shilpa Mehta and Dr. Resmy Palliyil Gopi",coverURL:"https://cdn.intechopen.com/books/images_new/11709.jpg",editedByType:null,editors:[{id:"342545",title:"Dr.",name:"Shilpa",surname:"Mehta",slug:"shilpa-mehta",fullName:"Shilpa Mehta"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11889",title:"Sexual Disorders and Dysfunctions",subtitle:null,isOpenForSubmission:!0,hash:"b988fda30a4e2364ee9d47e417bd0ba9",slug:null,bookSignature:"Dr. Dhastagir Sultan Sheriff",coverURL:"https://cdn.intechopen.com/books/images_new/11889.jpg",editedByType:null,editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11867",title:"Echocardiography",subtitle:null,isOpenForSubmission:!0,hash:"d9159ce31733bf78cc2a79b18c225994",slug:null,bookSignature:"Dr. Gabriel Cismaru",coverURL:"https://cdn.intechopen.com/books/images_new/11867.jpg",editedByType:null,editors:[{id:"191888",title:"Dr.",name:"Gabriel",surname:"Cismaru",slug:"gabriel-cismaru",fullName:"Gabriel Cismaru"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11556",title:"Numerical Simulation",subtitle:null,isOpenForSubmission:!0,hash:"0a68fbeb303684344bda285aa06769af",slug:null,bookSignature:"Dr. Ali Soofastaei",coverURL:"https://cdn.intechopen.com/books/images_new/11556.jpg",editedByType:null,editors:[{id:"257455",title:"Dr.",name:"Ali",surname:"Soofastaei",slug:"ali-soofastaei",fullName:"Ali Soofastaei"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11784",title:"Bryophytes - The State of Knowledge in a World Under Climate Change",subtitle:null,isOpenForSubmission:!0,hash:"80743b2add35e11b09c10e6895a45831",slug:null,bookSignature:"Prof. Jair Putzke",coverURL:"https://cdn.intechopen.com/books/images_new/11784.jpg",editedByType:null,editors:[{id:"324930",title:"Prof.",name:"Jair",surname:"Putzke",slug:"jair-putzke",fullName:"Jair Putzke"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:22},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:6},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:15},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:37},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:15},{group:"topic",caption:"Mathematics",value:15,count:8},{group:"topic",caption:"Medicine",value:16,count:62},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:2},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:5},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:241},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3737",title:"MATLAB",subtitle:"Modelling, Programming and Simulations",isOpenForSubmission:!1,hash:null,slug:"matlab-modelling-programming-and-simulations",bookSignature:"Emilson Pereira Leite",coverURL:"https://cdn.intechopen.com/books/images_new/3737.jpg",editors:[{id:"12051",title:"Prof.",name:"Emilson",middleName:null,surname:"Pereira Leite",slug:"emilson-pereira-leite",fullName:"Emilson Pereira Leite"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"1770",title:"Gel Electrophoresis",subtitle:"Principles and Basics",isOpenForSubmission:!1,hash:"279701f6c802cf02deef45103e0611ff",slug:"gel-electrophoresis-principles-and-basics",bookSignature:"Sameh Magdeldin",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4797},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7175,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1981,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2308,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1473,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318571,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271836,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",publishedDate:"July 1st 2013",numberOfDownloads:243450,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1582,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2082,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",publishedDate:"October 17th 2012",numberOfDownloads:256294,editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"399",title:"Molecular Dynamics",slug:"human-genetics-molecular-dynamics",parent:{id:"54",title:"Human Genetics",slug:"human-genetics"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:31,numberOfWosCitations:68,numberOfCrossrefCitations:22,numberOfDimensionsCitations:79,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"399",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"2265",title:"Molecular Dynamics",subtitle:"Studies of Synthetic and Biological Macromolecules",isOpenForSubmission:!1,hash:"58aa18b5670a4dcc031fe3d9006767aa",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",bookSignature:"Lichang Wang",coverURL:"https://cdn.intechopen.com/books/images_new/2265.jpg",editedByType:"Edited by",editors:[{id:"107906",title:"Prof.",name:"Lichang",middleName:null,surname:"Wang",slug:"lichang-wang",fullName:"Lichang Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"35489",doi:"10.5772/37107",title:"MM-GB(PB)SA Calculations of Protein-Ligand Binding Free Energies",slug:"mm-gb-pb-sa-calculations-of-protein-ligand-binding-free-energies",totalDownloads:8602,totalCrossrefCites:11,totalDimensionsCites:62,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Joseph M. Hayes and Georgios Archontis",authors:[{id:"102666",title:"Dr.",name:"Joseph",middleName:"M.",surname:"Hayes",slug:"joseph-hayes",fullName:"Joseph Hayes"},{id:"111282",title:"Prof.",name:"Georgios",middleName:null,surname:"Archontis",slug:"georgios-archontis",fullName:"Georgios Archontis"}]},{id:"35497",doi:"10.5772/35561",title:"Molecular Dynamics Simulation of Nanoscale Machining",slug:"molecular-dynamics-simulation-of-nanoscale-machining",totalDownloads:2531,totalCrossrefCites:5,totalDimensionsCites:8,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Akinjide Oluwajobi",authors:[{id:"104989",title:"Dr.",name:"Akinjide",middleName:null,surname:"Oluwajobi",slug:"akinjide-oluwajobi",fullName:"Akinjide Oluwajobi"}]},{id:"35481",doi:"10.5772/36289",title:"Introduction to Molecular Dynamics Simulations: Applications in Hard and Soft Condensed Matter Physics",slug:"introduction-to-molecular-dynamics-simulations-applications-in-hard-and-soft-condensed-matter-physic",totalDownloads:2353,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Martin Oliver Steinhauser",authors:[{id:"107752",title:"Dr.",name:"Martin",middleName:"Oliver",surname:"Steinhauser",slug:"martin-steinhauser",fullName:"Martin Steinhauser"}]},{id:"35485",doi:"10.5772/35955",title:"M.DynaMix Studies of Solvation, Solubility and Permeability",slug:"m-dynamix-studies-of-solvation-solubility-and-permeability",totalDownloads:2809,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Aatto Laaksonen, Alexander Lyubartsev and Francesca Mocci",authors:[{id:"106499",title:"Prof.",name:"Aatto",middleName:null,surname:"Laaksonen",slug:"aatto-laaksonen",fullName:"Aatto Laaksonen"},{id:"111652",title:"Prof.",name:"Alexander",middleName:null,surname:"Lyubartsev",slug:"alexander-lyubartsev",fullName:"Alexander Lyubartsev"},{id:"111653",title:"Prof.",name:"Francesca",middleName:null,surname:"Mocci",slug:"francesca-mocci",fullName:"Francesca Mocci"}]},{id:"35494",doi:"10.5772/36246",title:"Simulations of Unusual Properties of Water Inside Carbon Nanotubes",slug:"simulations-of-unusual-properties-of-water-inside-carbon-nanotubes",totalDownloads:2164,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Yoshimichi Nakamura and Takahisa Ohno",authors:[{id:"107624",title:"Dr.",name:"Yoshimichi",middleName:null,surname:"Nakamura",slug:"yoshimichi-nakamura",fullName:"Yoshimichi Nakamura"},{id:"112144",title:"Prof.",name:"Takahisa",middleName:null,surname:"Ohno",slug:"takahisa-ohno",fullName:"Takahisa Ohno"}]}],mostDownloadedChaptersLast30Days:[{id:"35485",title:"M.DynaMix Studies of Solvation, Solubility and Permeability",slug:"m-dynamix-studies-of-solvation-solubility-and-permeability",totalDownloads:2809,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Aatto Laaksonen, Alexander Lyubartsev and Francesca Mocci",authors:[{id:"106499",title:"Prof.",name:"Aatto",middleName:null,surname:"Laaksonen",slug:"aatto-laaksonen",fullName:"Aatto Laaksonen"},{id:"111652",title:"Prof.",name:"Alexander",middleName:null,surname:"Lyubartsev",slug:"alexander-lyubartsev",fullName:"Alexander Lyubartsev"},{id:"111653",title:"Prof.",name:"Francesca",middleName:null,surname:"Mocci",slug:"francesca-mocci",fullName:"Francesca Mocci"}]},{id:"35489",title:"MM-GB(PB)SA Calculations of Protein-Ligand Binding Free Energies",slug:"mm-gb-pb-sa-calculations-of-protein-ligand-binding-free-energies",totalDownloads:8602,totalCrossrefCites:11,totalDimensionsCites:62,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Joseph M. Hayes and Georgios Archontis",authors:[{id:"102666",title:"Dr.",name:"Joseph",middleName:"M.",surname:"Hayes",slug:"joseph-hayes",fullName:"Joseph Hayes"},{id:"111282",title:"Prof.",name:"Georgios",middleName:null,surname:"Archontis",slug:"georgios-archontis",fullName:"Georgios Archontis"}]},{id:"35482",title:"Molecular Dynamics Simulation of Synthetic Polymers",slug:"molecular-dynamics-simulation-in-synthetic-polymers",totalDownloads:4073,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Claudia Sandoval",authors:[{id:"102573",title:"Dr.",name:"Claudia",middleName:null,surname:"Sandoval",slug:"claudia-sandoval",fullName:"Claudia Sandoval"}]},{id:"35486",title:"Practical Estimation of TCR-pMHC Binding Free-Energy Based on the Dielectric Model and the Coarse-Grained Model",slug:"practical-estimation-of-tcr-pmhc-binding-free-energy-based-on-dielectric-model-and-coarse-graine-mod",totalDownloads:1733,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Hiromichi Tsurui and Takuya Takahashi",authors:[{id:"106238",title:"Dr.",name:"Hiromichi",middleName:null,surname:"Tsurui",slug:"hiromichi-tsurui",fullName:"Hiromichi Tsurui"},{id:"111076",title:"Prof.",name:"Takuya",middleName:null,surname:"Takahashi",slug:"takuya-takahashi",fullName:"Takuya Takahashi"}]},{id:"35493",title:"Studies of Cardio Toxin Protein Adsorption on Mixed Self-Assembled Monolayers Using Molecular Dynamics Simulations",slug:"studies-of-ctx-protein-adsorption-on-mixed-sams-surfaces-using-molecular-dynamics-simulations",totalDownloads:1903,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2265",slug:"molecular-dynamics-studies-of-synthetic-and-biological-macromolecules",title:"Molecular Dynamics",fullTitle:"Molecular Dynamics - Studies of Synthetic and Biological Macromolecules"},signatures:"Shih-Wei Hung, Pai-Yi Hsiao and Ching-Chang Chieng",authors:[{id:"109688",title:"Prof.",name:"Ching-Chang",middleName:null,surname:"Chieng",slug:"ching-chang-chieng",fullName:"Ching-Chang Chieng"}]}],onlineFirstChaptersFilter:{topicId:"399",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
\r\n
\r\n\t
\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
\r\n\t
\r\n
\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
\r\n
\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
\r\n
\r\n\t
\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:7,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. Her research interests include multi-criteria decision analysis, industrial plants, logistics, manufacturing, and safety. She serves as an associate editor for the International Journal of the Analytic Hierarchy Process and is an editorial board member for several other journals. She is also a member of the Analytic Hierarchy Process (AHP) Academy.",institutionString:"Parthenope University of Naples",institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"179628",title:"Prof.",name:"Dima",middleName:null,surname:"Jamali",slug:"dima-jamali",fullName:"Dima Jamali",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSAIlQAO/Profile_Picture_2022-03-07T08:52:23.jpg",institutionString:null,institution:{name:"University of Sharjah",institutionURL:null,country:{name:"United Arab Emirates"}}},{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş",profilePictureURL:"https://mts.intechopen.com/storage/users/170206/images/system/170206.png",institutionString:null,institution:{name:"Akdeniz University",institutionURL:null,country:{name:"Turkey"}}},{id:"250347",title:"Associate Prof.",name:"Isaac",middleName:null,surname:"Oluwatayo",slug:"isaac-oluwatayo",fullName:"Isaac Oluwatayo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVIVQA4/Profile_Picture_2022-03-17T13:25:32.jpg",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},{id:"141386",title:"Prof.",name:"Jesús",middleName:null,surname:"López-Rodríguez",slug:"jesus-lopez-rodriguez",fullName:"Jesús López-Rodríguez",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRBNIQA4/Profile_Picture_2022-03-21T08:24:16.jpg",institutionString:null,institution:{name:"University of A Coruña",institutionURL:null,country:{name:"Spain"}}},{id:"208657",title:"Dr.",name:"Mara",middleName:null,surname:"Del Baldo",slug:"mara-del-baldo",fullName:"Mara Del Baldo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLMUQA4/Profile_Picture_2022-05-18T08:19:24.png",institutionString:"University of Urbino Carlo Bo",institution:{name:"University of Urbino",institutionURL:null,country:{name:"Italy"}}}]},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"169536",title:"Dr.",name:"David",middleName:null,surname:"Claborn",slug:"david-claborn",fullName:"David Claborn",profilePictureURL:"https://mts.intechopen.com/storage/users/169536/images/system/169536.jpeg",institutionString:null,institution:{name:"Missouri State University",institutionURL:null,country:{name:"United States of America"}}},{id:"248594",title:"Ph.D.",name:"Jasneth",middleName:null,surname:"Mullings",slug:"jasneth-mullings",fullName:"Jasneth Mullings",profilePictureURL:"https://mts.intechopen.com/storage/users/248594/images/system/248594.jpeg",institutionString:"The University Of The West Indies - Mona Campus, Jamaica",institution:null},{id:"331299",title:"Prof.",name:"Pei-Shan",middleName:null,surname:"Liao",slug:"pei-shan-liao",fullName:"Pei-Shan Liao",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000032Fh2FQAS/Profile_Picture_2022-03-18T09:39:41.jpg",institutionString:"Research Center for Humanities and Social Sciences, Academia Sinica, Taiwan",institution:null}]},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"320585",title:"Dr.",name:"Deborah",middleName:null,surname:"Young",slug:"deborah-young",fullName:"Deborah Young",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002vZLcTQAW/Profile_Picture_2022-05-10T08:30:47.jpg",institutionString:"Empowering Communities Globally, United States of America",institution:null},{id:"348038",title:"Associate Prof.",name:"Feyza",middleName:null,surname:"Bhatti",slug:"feyza-bhatti",fullName:"Feyza Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/348038/images/system/348038.jpg",institutionString:"Girne American University, Cyprus",institution:{name:"Girne American University",institutionURL:null,country:{name:"Cyprus"}}},{id:"302382",title:"Dr.",name:"Gina",middleName:null,surname:"Alvarado",slug:"gina-alvarado",fullName:"Gina Alvarado",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002mZoL9QAK/Profile_Picture_2022-05-26T08:14:10.jpg",institutionString:null,institution:{name:"Landesa Rural Development Institute",institutionURL:null,country:{name:"United States of America"}}},{id:"128665",title:"Prof.",name:"Man-Chung",middleName:null,surname:"Chiu",slug:"man-chung-chiu",fullName:"Man-Chung Chiu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bR9OrQAK/Profile_Picture_2022-03-09T08:36:59.JPG",institutionString:null,institution:{name:"Beijing Normal University",institutionURL:null,country:{name:"China"}}}]},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"267257",title:"Dr.",name:"Wame",middleName:null,surname:"Hambira",slug:"wame-hambira",fullName:"Wame Hambira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZhvQAG/Profile_Picture_2022-06-09T08:16:15.jpg",institutionString:"Botswana University of Agriculture and Natural Resources, Botswana",institution:null},{id:"256906",title:"Dr.",name:"Zenebe",middleName:null,surname:"Mekonnen",slug:"zenebe-mekonnen",fullName:"Zenebe Mekonnen",profilePictureURL:"https://mts.intechopen.com/storage/users/256906/images/20300_n.jpg",institutionString:null,institution:{name:"Ethiopian Environment and Forest Research Institute",institutionURL:null,country:{name:"Ethiopia"}}}]},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. He holds a Master’s Degree in Urban Development Planning from the University College of London (UCL), and a Ph.D. in Urban Planning & Engineering from TU Berlin. He has conducted applied research on urban planning and infrastructure issues in over 20 countries in Africa and Asia. In 2005 he joined Eawag-Sandec as Leader of the Strategic Environmental Sanitation Planning Group. Since 2015 he heads the research department Sanitation, Water and Solid Waste for Development (Sandec) at the Swiss Federal Institute of Aquatic Research and Technology (Eawag).",institutionString:"Swiss Federal Institute of Aquatic Science and Technology, Switzerland",institution:{name:"Swiss Federal Institute of Aquatic Science and Technology",institutionURL:null,country:{name:"Switzerland"}}},editorTwo:{id:"290571",title:"Dr.",name:"Rui Alexandre",middleName:null,surname:"Castanho",slug:"rui-alexandre-castanho",fullName:"Rui Alexandre Castanho",profilePictureURL:"https://mts.intechopen.com/storage/users/290571/images/system/290571.jpg",biography:"Rui Alexandre Castanho has a master\\'s degree in Planning, Audit, and Control in Urban Green Spaces and an international Ph.D. in Sustainable Planning in Borderlands. Currently, he is a professor at WSB University, Poland, and a visiting professor at the University of Johannesburg, South Africa. Dr. Castanho is a post-doc researcher on the GREAT Project, University of Azores, Ponta Delgada, Portugal. He collaborates with the Environmental Resources Analysis Research Group (ARAM), University of Extremadura (UEx), Spain; VALORIZA - Research Center for the Enhancement of Endogenous Resources, Polytechnic Institute of Portalegre (IPP), Portugal; Centre for Tourism Research, Development and Innovation (CITUR), Madeira, Portugal; and AQUAGEO Research Group, University of Campinas (UNICAMP), Brazil.",institutionString:"University of Johannesburg, South Africa and WSB University, Poland",institution:{name:"University of Johannesburg",institutionURL:null,country:{name:"South Africa"}}},editorThree:null,editorialBoard:[{id:"181486",title:"Dr.",name:"Claudia",middleName:null,surname:"Trillo",slug:"claudia-trillo",fullName:"Claudia Trillo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSAZHQA4/Profile_Picture_2022-03-14T08:26:43.jpg",institutionString:null,institution:{name:"University of Salford",institutionURL:null,country:{name:"United Kingdom"}}},{id:"308328",title:"Dr.",name:"Dávid",middleName:null,surname:"Földes",slug:"david-foldes",fullName:"Dávid Földes",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002nXXGKQA4/Profile_Picture_2022-03-11T08:25:45.jpg",institutionString:null,institution:{name:"Budapest University of Technology and Economics",institutionURL:null,country:{name:"Hungary"}}},{id:"282172",title:"Dr.",name:"Ivan",middleName:null,surname:"Oropeza-Perez",slug:"ivan-oropeza-perez",fullName:"Ivan Oropeza-Perez",profilePictureURL:"https://mts.intechopen.com/storage/users/282172/images/system/282172.jpg",institutionString:"Universidad de las Américas Puebla",institution:{name:"Universidad de las Américas Puebla",institutionURL:null,country:{name:"Mexico"}}}]}]},overviewPageOFChapters:{paginationCount:27,paginationItems:[{id:"83092",title:"Novel Composites for Bone Tissue Engineering",doi:"10.5772/intechopen.106255",signatures:"Pugalanthipandian Sankaralingam, Poornimadevi Sakthivel and Vijayakumar Chinnaswamy Thangavel",slug:"novel-composites-for-bone-tissue-engineering",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biomimetics - Bridging the Gap",coverURL:"https://cdn.intechopen.com/books/images_new/11453.jpg",subseries:{id:"8",title:"Bioinspired Technology and Biomechanics"}}},{id:"82800",title:"Repurposing Drugs as Potential Therapeutics for the SARS-Cov-2 Viral Infection: Automatizing a Blind Molecular Docking High-throughput Pipeline",doi:"10.5772/intechopen.105792",signatures:"Aldo Herrera-Rodulfo, Mariana Andrade-Medina and Mauricio Carrillo-Tripp",slug:"repurposing-drugs-as-potential-therapeutics-for-the-sars-cov-2-viral-infection-automatizing-a-blind-",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Molecular Docking - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82582",title:"Protecting Bioelectric Signals from Electromagnetic Interference in a Wireless World",doi:"10.5772/intechopen.105951",signatures:"David Marcarian",slug:"protecting-bioelectric-signals-from-electromagnetic-interference-in-a-wireless-world",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82586",title:"Fundamentals of Molecular Docking and Comparative Analysis of Protein–Small-Molecule Docking Approaches",doi:"10.5772/intechopen.105815",signatures:"Maden Sefika Feyza, Sezer Selin and Acuner Saliha Ece",slug:"fundamentals-of-molecular-docking-and-comparative-analysis-of-protein-small-molecule-docking-approac",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Molecular Docking - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},overviewPagePublishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 7th 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11473",title:"Social Inequality - Structure and Social Processes",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",hash:"cefab077e403fd1695fb2946e7914942",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:49,paginationItems:[{id:"83087",title:"Role of Cellular Responses in Periodontal Tissue Destruction",doi:"10.5772/intechopen.106645",signatures:"Nam Cong-Nhat Huynh",slug:"role-of-cellular-responses-in-periodontal-tissue-destruction",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"83073",title:"Dental and Orofacial Trauma Impacts on Oral-Health-Related—Quality of Life in Children: Low- and Middle-Income Countries",doi:"10.5772/intechopen.105845",signatures:"Yolanda Malele-Kolisa, Nazia Khan, Mpho P. Molete, Maphefo D. Thekiso and Mzubanzi Mabongo",slug:"dental-and-orofacial-trauma-impacts-on-oral-health-related-quality-of-life-in-children-low-and-middl",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"82938",title:"Trauma from Occlusion: Practical Management Guidelines",doi:"10.5772/intechopen.105960",signatures:"Prashanth Shetty, Shweta Hegde, Shubham Chelkar, Rahul Chaturvedi, Shruti Pochhi, Aakanksha Shrivastava, Dudala Lakshmi, Shreya Mukherjee, Pankaj Bajaj and Shahzada Asif Raza",slug:"trauma-from-occlusion-practical-management-guidelines",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"82654",title:"Atraumatic Restorative Treatment: More than a Minimally Invasive Approach?",doi:"10.5772/intechopen.105623",signatures:"Manal A. Ablal",slug:"atraumatic-restorative-treatment-more-than-a-minimally-invasive-approach",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82608",title:"Early Management of Dental Trauma in the Era of COVID-19",doi:"10.5772/intechopen.105992",signatures:"Khairul Bariah Chi Adam, Haszelini Hassan, Pram Kumar Subramaniam, Izzati Nabilah Ismail, Nor Adilah Harun and Naziyah Shaban Mustafa",slug:"early-management-of-dental-trauma-in-the-era-of-covid-19",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"82767",title:"Teeth Avulsion",doi:"10.5772/intechopen.105846",signatures:"Manal Abdalla Eltahir, Randa Fath Elrahman Ibrahim and Hanan Alharbi",slug:"teeth-avulsion",totalDownloads:21,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"82735",title:"The Influence of Salivary pH on the Prevalence of Dental Caries",doi:"10.5772/intechopen.106154",signatures:"Laura-Cristina Rusu, Alexandra Roi, Ciprian-Ioan Roi, Codruta Victoria Tigmeanu and Lavinia Cosmina Ardelean",slug:"the-influence-of-salivary-ph-on-the-prevalence-of-dental-caries",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82288",title:"Dental Emergency and Conditions",doi:"10.5772/intechopen.105495",signatures:"Navneet Kaur",slug:"dental-emergency-and-conditions",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"81961",title:"Antioxidants as an Adjuncts to Periodontal Therapy",doi:"10.5772/intechopen.105016",signatures:"Sura Dakhil Jassim and Ali Abbas Abdulkareem",slug:"antioxidants-as-an-adjuncts-to-periodontal-therapy",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"82357",title:"Caries Management Aided by Fluorescence-Based Devices",doi:"10.5772/intechopen.105567",signatures:"Atena Galuscan, Daniela Jumanca and Aurora Doris Fratila",slug:"caries-management-aided-by-fluorescence-based-devices",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}}]},subseriesFiltersForOFChapters:[{caption:"Prosthodontics and Implant Dentistry",value:2,count:23,group:"subseries"},{caption:"Oral Health",value:1,count:26,group:"subseries"}],publishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"10840",title:"Benzimidazole",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10840.jpg",slug:"benzimidazole",publishedDate:"July 13th 2022",editedByType:"Edited by",bookSignature:"Pravin Kendrekar and Vinayak Adimule",hash:"e28c770013e7a8dd0fc37aea6aa9def8",volumeInSeries:34,fullTitle:"Benzimidazole",editors:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",slug:"protein-detection",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Yusuf Tutar and Lütfi Tutar",hash:"2f1c0e4e0207fc45c936e7d22a5369c4",volumeInSeries:31,fullTitle:"Protein Detection",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",institutionString:"University of Health Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"2c628f4757f9639a4450728d839a7842",volumeInSeries:30,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:14}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:9},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:30,paginationItems:[{id:"425474",title:"Mr.",name:"Jasper",middleName:"Okoro Godwin",surname:"Okoro Godwin Elechi",slug:"jasper-okoro-godwin-elechi",fullName:"Jasper Okoro Godwin Elechi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/425474/images/19990_n.jpg",biography:"Mr. Elechi is an innovative and passionate food professional and educator who can collaborate across boundaries with an integrated aspiration of innovation to provide good, sustainable, and healthy food solutions that promote human health and conserve planetary health. He has a special interest in innovative food product development, nutrition, indigenous food products, biotechnology, bioeconmy, sustainable global food systems transformation, food safety Nanotechnology, and Nanomaterials. He has carried out independent research and publications in these areas. He possesses comprehensive knowledge and technical know-how on nutritional formulation and production of healthy and sustainable foods from locally available underutilized Cereal-Legume crops for combating food security and malnutrition in developing communities.",institutionString:null,institution:null},{id:"307387",title:"Dr.",name:"Cecilia",middleName:null,surname:"Camporeale",slug:"cecilia-camporeale",fullName:"Cecilia Camporeale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Agency For New Technologies, Energy and Sustainable Economic Development",country:{name:"Italy"}}},{id:"296882",title:"Dr.",name:"Mario",middleName:null,surname:"Jorizzo",slug:"mario-jorizzo",fullName:"Mario Jorizzo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Agency For New Technologies, Energy and Sustainable Economic Development",country:{name:"Italy"}}},{id:"307388",title:"Dr.",name:"ROBERTO",middleName:null,surname:"DEL CIELLO",slug:"roberto-del-ciello",fullName:"ROBERTO DEL CIELLO",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Agency For New Technologies, Energy and Sustainable Economic Development",country:{name:"Italy"}}},{id:"437647",title:"M.Sc.",name:"Fernando",middleName:null,surname:"Teixeira",slug:"fernando-teixeira",fullName:"Fernando Teixeira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"423338",title:"Dr.",name:"Harjeet",middleName:null,surname:"Singh",slug:"harjeet-singh",fullName:"Harjeet Singh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Chitkara University",country:{name:"India"}}},{id:"443635",title:"Dr.",name:"Suruchi",middleName:null,surname:"Jindal",slug:"suruchi-jindal",fullName:"Suruchi Jindal",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Punjab Agricultural University",country:{name:"India"}}},{id:"426265",title:"Mrs.",name:"Inonge",middleName:null,surname:"Chibua",slug:"inonge-chibua",fullName:"Inonge Chibua",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Botswana",country:{name:"Botswana"}}},{id:"426266",title:"Ms.",name:"Mesha",middleName:null,surname:"Mbisana",slug:"mesha-mbisana",fullName:"Mesha Mbisana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Botswana",country:{name:"Botswana"}}},{id:"426264",title:"Mr.",name:"Samuel",middleName:null,surname:"Raditloko",slug:"samuel-raditloko",fullName:"Samuel Raditloko",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Botswana",country:{name:"Botswana"}}},{id:"426394",title:"Dr.",name:"Mags",middleName:null,surname:"Adams",slug:"mags-adams",fullName:"Mags Adams",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Central Lancashire",country:{name:"United Kingdom"}}},{id:"441182",title:"Dr.",name:"Neil",middleName:null,surname:"Wilson",slug:"neil-wilson",fullName:"Neil Wilson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Central Lancashire",country:{name:"United Kingdom"}}},{id:"425171",title:"Ph.D. Student",name:"Tanya",middleName:null,surname:"Zerbian",slug:"tanya-zerbian",fullName:"Tanya Zerbian",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Central Lancashire",country:{name:"Cyprus"}}},{id:"424714",title:"Prof.",name:"Elke",middleName:null,surname:"Stedefeldt",slug:"elke-stedefeldt",fullName:"Elke Stedefeldt",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",country:{name:"Brazil"}}},{id:"425244",title:"Dr.",name:"Rayane",middleName:"Stephanie Gomes",surname:"Stephanie Gomes De Freitas",slug:"rayane-stephanie-gomes-de-freitas",fullName:"Rayane Stephanie Gomes De Freitas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",country:{name:"Brazil"}}},{id:"424688",title:"Dr.",name:"Bart",middleName:null,surname:"de Steenhuijsen Piters",slug:"bart-de-steenhuijsen-piters",fullName:"Bart de Steenhuijsen Piters",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"429404",title:"Dr.",name:"Emma",middleName:null,surname:"Termeer",slug:"emma-termeer",fullName:"Emma Termeer",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"429407",title:"Dr.",name:"Herman",middleName:null,surname:"Brouwer",slug:"herman-brouwer",fullName:"Herman Brouwer",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"429406",title:"Dr.",name:"Hubert",middleName:null,surname:"Fonteijn",slug:"hubert-fonteijn",fullName:"Hubert Fonteijn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"427504",title:"Dr.",name:"Kriengsak",middleName:null,surname:"Chareonwongsak",slug:"kriengsak-chareonwongsak",fullName:"Kriengsak Chareonwongsak",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"423333",title:"Ph.D. Student",name:"Shivani",middleName:null,surname:"Sood",slug:"shivani-sood",fullName:"Shivani Sood",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"452297",title:"Mr.",name:"Cornelius",middleName:null,surname:"Smah Adamu",slug:"cornelius-smah-adamu",fullName:"Cornelius Smah Adamu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"452296",title:"Mr.",name:"Ikechukwu",middleName:null,surname:"U. Nwiyi",slug:"ikechukwu-u.-nwiyi",fullName:"Ikechukwu U. Nwiyi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"423395",title:"Assistant Prof.",name:"Adane",middleName:null,surname:"Atara Debessa",slug:"adane-atara-debessa",fullName:"Adane Atara Debessa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"426267",title:"Mr.",name:"Banyaladzi",middleName:null,surname:"Paphane",slug:"banyaladzi-paphane",fullName:"Banyaladzi Paphane",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"483388",title:"Dr.",name:"Berhanu",middleName:null,surname:"Denu",slug:"berhanu-denu",fullName:"Berhanu Denu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"483387",title:"Dr.",name:"Degefa",middleName:null,surname:"Tolossa",slug:"degefa-tolossa",fullName:"Degefa Tolossa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"426059",title:"Dr.",name:"Dikabo",middleName:null,surname:"Mogopodi",slug:"dikabo-mogopodi",fullName:"Dikabo Mogopodi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"422909",title:"Dr.",name:"Dorcas Stella",middleName:null,surname:"Shumba",slug:"dorcas-stella-shumba",fullName:"Dorcas Stella Shumba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"429405",title:"Dr.",name:"Deborah",middleName:null,surname:"Bakker",slug:"deborah-bakker",fullName:"Deborah Bakker",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",slug:"cesar-lopez-camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]},onlineFirstChapters:{paginationCount:2,paginationItems:[{id:"82936",title:"Soil Degradation Processes Linked to Long-Term Forest-Type Damage",doi:"10.5772/intechopen.106390",signatures:"Pavel Samec, Aleš Kučera and Gabriela Tomášová",slug:"soil-degradation-processes-linked-to-long-term-forest-type-damage",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}},{id:"82124",title:"Assessment of Diversity, Growth Characteristics and Aboveground Biomass of Tree Species in Selected Urban Green Areas of Osogbo, Osun State",doi:"10.5772/intechopen.104982",signatures:"Omolara Aremu, Olusola O. Adetoro and Olusegun Awotoye",slug:"assessment-of-diversity-growth-characteristics-and-aboveground-biomass-of-tree-species-in-selected-u",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}}]},publishedBooks:{paginationCount:5,paginationItems:[{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"3",title:"Bacterial Infectious Diseases",scope:"
\r\n\tThe era of antibiotics led us to the illusion that the problem of bacterial infection is over. However, bacterial flexibility and adaptation mechanisms allow them to survive and grow in extreme conditions. The best example is the formation of a sophisticated society of bacteria defined as a biofilm. Understanding the mechanism of bacterial biofilm formation has changed our perception of the development of bacterial infection but successfully eradicating biofilm remains a challenge. Considering the above, it is not surprising that bacteria remain a major public health threat despite the development of many groups of antibiotics. Additionally, increasing prevalence of acquired antibiotic resistance forces us to realize that we are far from controlling the development of bacterial infections. On the other hand, many infections are endogenous and result from an unbalanced relationship between the host and the microorganism. The increasing use of immunosuppressants, such as chemotherapy or organ transplantation, increases the incidence of patients highly susceptible to bacterial infections in the population.
\r\n
\r\n\tThis topic will focus on the current challenges and advantages in the diagnosis and treatment of bacterial infections. We will discuss the host-microbiota relationship, the treatment of chronic infections due to biofilm formation, and the development of new diagnostic tools to rapidly distinguish between colonization and probable infection.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",keywords:"Antibiotics, Biofilm, Antibiotic Resistance, Host-microbiota Relationship, Treatment, Diagnostic Tools"},{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/68628",hash:"",query:{},params:{id:"68628"},fullPath:"/chapters/68628",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()