Results of samples under non-predictive pattern measurement protocol.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"234",leadTitle:null,fullTitle:"Acute Phase Proteins - Regulation and Functions of Acute Phase Proteins",title:"Acute Phase Proteins",subtitle:"Regulation and Functions of Acute Phase Proteins",reviewType:"peer-reviewed",abstract:"The two volumes of Acute Phase Proteins book consist of chapters that give a large panel of fundamental and applied knowledge on one of the major elements of the inflammatory process during the acute phase response, i.e., the acute phase proteins expression and functions that regulate homeostasis. 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He received from the Montpellier University his Ph.D. in 1986. He was a post-doctoral laureate fellow (1987-8) on molecular biology at CNRS. From this date, he has been heading/coordinating several dozens of projects on viral pathogenesis (eg: HIV, Dengue, Hantavirus, Ebola, SARS-CoV-2) funded by international agencies, including the European Commission (2006 -2022). He created biotech companies (ApoH-Technologies) and platforms BSL2/3. He is a member of different evaluation panels (NIH, European Council, Frontiers in Immunology, etc). 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A normal non-ionizing radiation (NIR) is that which is produced from a radiation mechanism based on electromagnetic propagation and its propagation components; that is, it follows a radiation mechanism where the electromagnetic wave encounters a discontinuity in its path waveguide, being forced to change the shape of longitudinal propagation within a closed environment to a spread radiation in an open environment.
The typical discontinuity that is used for the radiation to be efficient and allows controlling to some degree the propagation of an essentially isotropic radiation and transforming it into a directional radiation is the element called antenna.
An antenna, in essence, transforms an ideal isotropic radiation into a radiation that concentrates, in a certain direction, in the energy coming from a source of electromagnetic radiation. In this chapter, we analyze the characteristics of the normal radiations that generate predictive patterns based on the propagation characteristics and those of the antennas with respect to non-predictive patterns. To verify this alteration of the patterns, measurement points with discordant values were obtained in a specific campaign.
The energy radiated by an antenna will be distributed uniformly in all directions and with divergent direction of the source, which in this case is the antenna, this case is also ideal since the radiation cannot be precise considering that the antenna does not it is more than a discontinuous prolongation of a transmission line and therefore has a feature of balanced line or balanced lines, this implies the existence of two elements or arms and therefore an antenna is basically a dipole.
This implies that, in essence, the radiation will have zero in the directions axial to the axis of that dipole.
In this way, if the dipole is placed with alignment to the Z axis, that is to say in a vertical position, the radiation null will be at ±90 of the dipole antenna itself.
In the case that the antenna is aligned with the axis y or x, the minimum radiation will be aligned with the corresponding axis.
However, the generality for broadcasting or cell phone transmission dipole antennas has an orientation on the Z axis in such a way that the main polarization is the so-called vertical polarization.
This means that the electric field vector has the same direction as the originating antenna, i.e., vertical (aligned with the Z axis), and that the magnetic field vector is of horizontal orientation since it will always be perpendicular to the vector of magnetic field enunciated in Maxwell’s equations.
Radiation emitted by a dipole is conditioned by two factors that are not directly related to propagation or radiation and if the electrical characteristics of the circuit between a transmitting device and an antenna are:
Adaptation efficiency
Radiation efficiency
The adaptation efficiency depends on the adaptation of impedances between the transmission line and the antenna, where what is sought is that the impedance of the antenna constitutes the conjugate transpose of the impedance of the transmission line in which case the adaptation is perfect (Figure 1).
Thevenin model of transmission of an antenna.
The radiation efficiency is specified by the relation between the totality of the energy that is delivered by the transmission line to the antenna and the energy actually radiated by it. The ideal situation is for the antenna to behave as an electrical element of resistance equal to zero, so that 100% of the energy delivered is radiated, this being an unrealizable situation; however, a part of the energy delivered is transformed into heat by Joule effect and is conditioned by the quality of the physical components of the antenna.
Therefore, the gain is conditioned by two efficiencies in such a way that the gain must be affected by the relationship between the impedance of the line and the antenna and the relationship between the ohmic and radiation resistances.
However, these considerations are not the only ones to be carried out for wireless communication and in particular for cellular telephony due to two factors:
Limitation on profit
Unequal coverage
The gain of an antenna is defined based on a factor called directivity.
The directivity is a factor that is given by the deformation of the radiation lobe that has a dipolar antenna and is measured as a relationship between a totally isotropic radiation and the radiation of a lobe that has an angular aperture bounded by a certain value less than that of isotropic radiation that has a 360-degree lobe.
The directivity can be defined as the lobe whose opening is limited by the angles that limit radiation with a drop of 3 decibels with respect to the maximum.
So the lobe will have a maximum of radiation in some direction and will have a smaller amount of radiation in directions with different angles from the maximum, that angle where it is verified that falls 3 decibels with respect to the maximum constitutes the limit of the radiation lobe or half power points. In short, the angle of opening will be twice the angle between the direction of the main lobe and the direction of the points of half power.
Obviously, the energy is not dispersed but is concentrated within the radiation lobe, i.e., the Poynting vector of the radiation lobe will have its maximum in the main direction of it and will decrease in different directions to that of the main lobe (Figure 2).
Directivity of an antenna.
The gain of the antenna as previously expressed depends directly on the directivity so that the lower the opening of the lobe, the greater the verified directivity and, consequently, the greater the gain allocated to the antenna.
As a consequence, the Poynting vector has a much higher value in the main direction of the radiation lobe, where the greater part of the radiated energy is concentrated, so that to have greater radiated energy, a greater directivity is needed.
That is why what is sought in an antenna, in most cases, is the directivity, since having more energy in the center of the lobe, the attenuation will have a lesser effect and you can have a communication that arrives with good energy level at a greater distance.
The design of an antenna is based on the fundamental premise that the radiation lobe, both vertically and horizontally, is calculated for the electric field of the radiated wave.
However, the search in wireless communications is based on achieving the maximum use of radiated energy to achieve propagation distances as long as possible, which are why the gain of the antenna is the main factor in the efficiency of telecommunications.
Coverage is the geographical area in which the energy radiated by a radiator element such as an antenna has such a value that it can be exploited by an electronic receiving device.
That is, it is the area where the signal has a suitable value so that the receiving electronic equipment can adequately transform the electromagnetic signal into an electrical signal with an adequate signal-to-noise ratio in order to be intelligible information.
Depending on the type of coverage required, it will be the characteristic of the antenna that is used to radiate.
If what is required is an omnidirectional radiation, a dipole antenna is more than enough; however, it is precisely this antenna that has the lowest gain and, therefore, although it achieves an omnidirectional coverage, the attenuation it suffers is so strong that the coverage it has is very deficient.
That is why, for the omnidirectional coverage, antennas with a characteristic in the horizontal lobe of high aperture and in the vertical radiation lobe of high directivity are used.
A generic situation is to achieve the 360° coverage by antennas that have a horizontal lobe opening of 120° placing in this case three antennas or even placing 6 antennas with 60° openings.
As far as the coverage in distance is concerned, it depends on the vertical lobe opening and how it is required to achieve the widest possible coverage. It is required that the effects of the attenuation in the free space be compensated by the high gain or directivity that the antenna has.
For this, antenna panels with apertures smaller than 20° are used (Figure 3).
Huawei Dual Band Panel Radiation Diagram ADU4518R3 [
This coverage is usually referred to as the footprint of the antenna and the situation generates that in the areas closest to the antenna there is more radiation in the case that the center of the radiation lobe is aimed at the point closest to the antenna.
What is required, for a good coverage, is that all users have reasonably the same level of signal. It is customary to make the center of the radiation lobe point toward the most extreme point, so that the signal level at the most extreme point coincides with the maximum of the radiation lobe. In the same way, those points that coincide with the minimum values of the radiation ovule, i.e., the 3 decibel points, are those that have less attenuation by distance.
In this way, the radiation lobe will tilt such that the level of radiation that will suffer the least attenuation by distance will fall at the point of coverage closest to the antenna and that the center of the radiation lobe having the highest power will suffer the greater attenuation in such a way that the coverage is equalized between both extremes and the users do not feel the decrease of the signal given by the attenuation in the free space (Figure 4).
Coverage method by downtilt [
It is evident that the height of the tower on which the antenna is located has a direct influence on the coverage area; however, there is a limitation that has to do with the attenuation in the free space so that the height of the tower has a practical limit that has to do with coverage and attenuation.
where A is the downtilt angle of the main beam, H is the height of the antenna relative to the ground, and BW is the angle of opening of the lobe for 3 dB of fall with respect to the main lobe.
These trigonometric equations give us the rule that the largest distance will depend on the angle of inclination that is the lowest, possibly and logically, and will also depend on the height of the tower as it has a direct proportionality.
It is very evident that if the value of the bandwidth of the beam width is 15° half of it will be 7° and the minimum distance of radiation from the base of the antenna would be corresponding to 7°. However, this would imply that it is directly pointing down. (A = 90°), which is not feasible or economically acceptable.
Considering that the Poynting vector analyzed practically how radiation density per unit area is 100 watts over square centimeters, a normal tread has a radiation density value of the order of 0.2 W/cm2. This value is very important to take into account in the study of electromagnetic emission, derived from the radiation of a cell phone installation, characterizing the emission in the exclusive values of the frequency spectrum used by this application, for which the considered emission is in the values of 700 megahertz at 2.3 GHz
These values are directly related to the tread and with the radiated power from the radio bases and correspond to an average value of −79 decibels.
Mobile cellular equipment in turn will change its data reception system depending on the signal level in such a way that when receiving a signal lower than this value, it will automatically change to Enhanced Data Rates for GSM Evolution (EDGE) or General Packet Radio Service (GPRS) mode.
Therefore, the signal level will directly affect the speed of the internal modems of cellular equipment.
Another aspect that has to be taken into account is what is normal radiation has to do with the emitting antennas.
The mobile telephone antennas are characterized by being bi-directional (emission or reception) of low power. In addition to producing RF radiation, they are mounted on poles, transmission towers, or the roofs of tall buildings, since they need to be at a certain height in order to have a wider coverage.
In a typical mobile telephone antenna, the radio emission is made toward the front and horizontally, in the form of a substantially flat beam, and covers a sector between 60 and 120°. Emissions are almost non-existent in the other directions (back, bottom, and top).
The characteristics of the antennas and the conditions in which they are usually installed make the emission levels in terms of radiation density very low in the place where they are located.
The flat panel antennas, as the name suggests, are a square- or rectangular-shaped panel. And they are configured in a patch-type format. Flat panel antennas are very directional since most of their radiated power is a single direction in either the horizontal or the vertical plane. In the elevation pattern (Figure 5) and in the azimuth pattern (Figure 6) [3], you can see the directivity of the flat panel antenna.
Flat elevation pattern high gain panel [
Azimuth flat high gain panel pattern [
The flat panel antennas can be manufactured in different directivity values according to their construction. This can provide excellent directivity and considerable gain.
These panels, in fact, are an array of 4 or 5 antennas whose separation between each other within the panel and the different paths that run through the signal in the waveguides that feed them provide an additional tilt (called an electric tilt).
The angle of inclination of the main lobe is the sum of the mechanical TILT (conditioned by mobile supports) and the electric TILT given by the regulation of the paths (phase delays) of the power supply of each antenna of the array installed in a panel (Figure 7).
Angle of an array of antennas caused by different phases [
Normal radiation follows a predictive pattern in which there are components that allow to know what is the power density value in the surface based on:
The power with which the antenna is fed
The attenuations of the connections
The antenna gain affected by the coupling coefficients and radiation loss coefficient
The attenuation in free space
The resulting value can still be added to a variety of attenuations produced by the surrounding environment that can be characterized as:
High density urban
Urban low density
Suburban
Rural
These attenuation parameters have been contemplated in various models such as the following:
This model is used to predict the power of the signal when there is a clear line of sight between the transmitter and the receiver. Satellite communication systems and microwave links can be modeled as free space propagation. The free space model predicts that the received power decays as a function of the separation distance between the transmitter and receiver raised to some power. The power received in the free space by a receiving antenna, which is separated from the transmitting antenna by a distance d, is given by the equation.
Where Pt is the transmitted power, Pr is the received power that is a function of the Tx-Rx separation (transmitter-receiver), Gt is the transmit antenna gain, Gr is the gain of the receiving antenna, D is the separation distance of Tx-Rx given in meters, λ is the wavelength given in meters, and L depends on the obstacles, line of sight is = 1.
The equation shows that the power of the received signal is attenuated to form the square of the distance between the transmitter and the receiver, which implies that 20 dB /decade decays.
The Okumura model [5] is one of the most widely used for signal prediction in urban areas. This model is applicable for frequencies in the range of 150–1920 MHz, that is, it comprises the VHF and UHF band (however, it is typically extrapolated for frequencies above 3000 MHz entering the SHF band) and distances of 1 Km to 100 Km. It can be used for antenna heights of the base station in the range of 30–1000 m.
The model can be expressed as:
where L50 (dB) is the median attenuation per trajectory, LF is the free space attenuation, Amu (f, d) is the average relative attenuation (curves), G (htx) is the height gain of the Tx antenna, G (hrx) is the height gain of the Rx antenna, and GAREA is the gain due to the type of environment.
Okumura found that G (hte) varies at an index of 20 dB/decade and G (hre) varies at an index of 10 dB/decade for heights less than 3 m.
G (hte) = 20log (hte/200) for 30 m < hte < 1000 m
G (hre) = 10log (hre/3) for hre < 3 m
G (hre) = 20log (hre/3) for 3 m < the <10 m
It is one of the simplest and most suitable models for attenuation predictions.
It is an empirical formulation of the propagation loss data provided by Okumura and is valid in the frequency range of VHF and UHF, from 150 to 1500 MHz. Although Hata [5] presented the losses within an urban area as a standard formula:
Taking into account that:
150 MHz < fc <1500 MHz
30 m < hte <200 m
1 m < hre <10 m
It should be considered that the definitions are the same as for the Okumura model, including:
fc: carrier frequency [MHz].
the height of the transmitting antenna in [m] in the range from 30 to 200 meters.
hre: receiving antenna height in [m] in the range from 1 to 10 meters.
a (hre): correction factor for the effective height of the mobile antenna that is function of the type of service area.
d: distance between transmitter and receiver [km].
As can be seen, it involves a new variable that is the correction factor of the mobile antenna and is defined according to the size of the city:
For small- and medium-sized cities:
For large cities:
The following is the formula that can be used in a suburban environment:
For rural areas:
This model adapts very well for the design of large-scale systems, but not for PCS systems, which have cells of the order of 1 km radius. For this purpose, a numerical-empirical formulation of the graphical data provided by Okumura of attenuation for urban areas is made.
The European Cooperative for Scientific and Technical Research (EURO-COST) [5] developed the COST 231 model, in which it extends the Hata model up to the 2 GHz range covering the VHF and UHF bands. The model is expressed as:
where CM is a correction factor to adapt the model by extending the frequency range for which the Hata model operates, CM is 0 dB for medium-sized cities and suburban areas, CM is 3 dB for metropolitan centers, and a (hre) corresponds to the equations presented in the previous topic (Hata Model).
One of the contributions of this model is to consider dispersion losses.
It is also defined in the following range:
f: 1500–2000 MHz
Th: 30–200 m
hre: 1–10 m
d: 1–20 km
Although the above are mitigation calculations, the regulations applied in Argentina are those issued by CNC (National Communications Commission) under resolution number 3690 of 2004 [6].
In the aforementioned, reference is made to the fact that prior to any measurement, a predictive calculation based on attenuation in space must be made, which takes into account the antenna power to calculate the radiation density in relation to the distance.
where S is the power density in
Measurements of non-ionizing radiation are clearly developed not only with a number of works on the subject, only to exemplify the work of Azpurua et al. [7], the thesis work of Br. Jorge Juan Eduardo Ríos Solar [8], or the work that preceded it [9] and the relevant regulations in Argentina. In all these works and even regulations, measurements are made or measurements based on the theoretical radiation lobes are standardized of the installations taken as a reference for the emission of non-ionizing radiation.
This research developed a plan of field measurements, which focused on areas already studied in the project “Analysis of Measurements of Non-Ionizing Radiation in the City of Salta from the UCASAL” [9]. It was extended for 2 months in the areas studied and new areas.
The methodology emanating from RES N ° 3690/04 was used because the following stipulations were applied:
The measurement must be made at accessible points by the public.
The measurement points will be chosen according to the characteristics of the system.
Irradiation and the wavelength of the emissions, where “applicable a the predictive calculations”.
For omnidirectional systems, at least 16 points should be selected, conveniently located on the ground, whose separation from the station is a function of the wavelength of the emitter.
Factors that influence the response of the instruments:
The following should be taken into account when making measurements:
Variation of the impedance of antennas or probes in the vicinity of conductive surfaces
Capacitive coupling between the probe and the field radiation source
The influence of these factors can be reduced by maintaining a separation greater than 20 cm or three times the size of the probe, whichever is greater, with respect to the source of re-irradiation field. That is why it is recommended that the antennas and/or probes are installed on tripods of non-conductive material.
In all cases, the instruments used were a TES-92 and TM-190 (TENMARS); previously, a contrast of measurements was made with an NARDA −550 that was taken as a calibration standard in a total of 25 measurements, the dispersion of results of 10% for TES-92 and 22% for TM-190, so the measurements presented correspond (unless specific indication) to TES-92.
The characteristics of the instrument are:
Sensor type: electric field (E)
Frequency range: 50–3.5 GHz
Directional characteristic: isotropic, three-dimensional
Measuring range (signal >50 MHz): 20 mV/m up to 108.0 V/m
Error of use (@ 1 V/m and 50 MHz): ± 1.0 dB
Frequency response (taking into account the number Factor CAL Factor: ±1.0 dB (50 MHz–1.9 GHz), ±2.4 dB (1.9–35 GHz)
The noise deviation: Type. ±1.0 dB f > 50 MHz
Load limit: 4.2 W/m2 (40 V/m)
The Miguel Ortiz site is an area centered on a monopost and located in the northern area of the city of Salta. It is characterized for being a suburban and quasi-rural location, since two of the panels partially cover areas corresponding to the field. It also covers an area of the Bolivian avenue that is an urban continuation of the highway of the same name. That is why in the path marked according to the regulations, there are rough areas of absolute clearance and line of sight (Figures 8 and 9).
Miguel Ortiz site measurement area.
Graph of radiation density measurements and predictive patterns. Miguel ortiz site.
Some deviations (attributed to motorway conditions) can be seen, although the trend of the curve follows a predictive pattern
This site is relevant because the first 150 ms of separation from the antenna are in free space due to the presence of a clear field; here, the installation is of a self-supporting tower 40 meters high (Figures 10 and 11).
Castañares site measurement route.
Graph of radiation density measurements and predictive patterns. Castañares site.
A correction by footprint is made linearly from the point of −3 dB not taking into account the real lobe but an approximation that does not take secondary lobes into account.
In both cases, it can be observed that there is a clearance at least in the first section of the measurement and that it responds to the calculation trend taking into account the theoretical tread.
The uniformity in density values along the tread is also denoted, which is a desirable effect and compatible with an expected behavior for mobile telephony coverage.
During the measurement process referred to in the work “Analysis of Measurements of Non-Ionizing Radiation in the City of Salta from the UCASAL” [10], a series of random measurements were taken and also values were found that do not respond to a predictive pattern within urban trajectories and in trajectories in suburban environments but with sufficient clearance to be considered with little incidence of buildings; however, it was observed that there are phenomena that cannot be predicted with the stated models since they correspond to the attenuation in the free space and this is added in all cases of additional attenuations.
The cases that are listed show sites where, in the level of radiation density, not only does it not follow a predictive pattern, but also the level of radiation density increases.
The measurement in the Aeroclub Salta site constitutes the first measurement parameter discordant with the applied theory from the point of view of both the attenuation in the free space and the correction by tread (Figures 12 and 13).
Measurement trajectory and discordant points. Aeroclub Salta site.
Graph of radiation density measurements and predictive patterns. Aeroclub Salta site.
The point located at 200 meters and the point located at 180 meters completely change the predictivity of the measurement; although the scope of measurement is free space in most of the path, the jarring factor is given in a point close to metal signage with a minimum height of 3 meters.
This is a completely suburban site in the Tres Cerritos neighborhood of the City of Salta. It is a self-supporting tower 65 meters high and has a large number of panels as it is used by three telephone companies to provide service in the area. Measurements followed a path in a street (Las Acacias) that provides a line of sight of good quality and there is even a square with ample clearance (Figures 14 and 15).
Measurement trajectory and discordant points. Guayacanes site.
Graph of radiation density measurements and predictive patterns. Guayacanes site.
The values measured in this area are much higher than the trend, and additionally, they are punctual since, as the advance of the planned measurement path continues, they return to their normal value.
It can be seen that in a high clearance area there are highly discordant points
The aerial lines of low- and medium-voltage lines are in some cases considered as causing a probability of increase in the radiation density by radiofrequency, which is why it is worth considering what the applicable concept of immission is and what the ranges of measurement of the immission sensors used by the instruments are.
As can be inferred from [11], “this term refers (in law) to an attack, aggression or attack of environmental type or also to a concentration, agglutination or conglomeration of pollution or the transfer of pollutants in a place or site and at a specific moment, more in common in the air and in general to an electromagnetic energy or radioactive particles.”
The analysis of the definition is very useful because the agglutination does not imply a sum necessarily (it is an essentially biological concept) [12] and the possibility of a concentration.
In the case of electromagnetic immission, it must be considered that the sensors used for measurement are made in the three electric field vectors (x and z) and the sum is a vector sum of these fields.
However, the sensed fields start from frequencies from 100 Khz. If we consider the harmonic spectrum of an electrical network, this would correspond to a harmonic of order 2000, considering 50 Hz as fundamental frequency, so it cannot be considered to the radiation of electric lines as a member of the emission that can be measured by RNI sensors.
Such is the case that there are no sensors with such a large bandwidth to detect RF radiation with values below 100 KHz [13], and in fact the detectors are based on Schottky diodes with bounded bandwidths, hence the need to change the probe for certain high-frequency measurements.
In the research project “Analysis of non-predictive patterns of non-ionizing radiation in a sector of the northern area of the City of Salta” approved by the research council of the UCASAL a plan of measurements inside and outside lobe trajectories is planned of radiation, a work methodology and a measurement protocol were implemented in accordance with the objective of identifying and characterizing points where the radiation value exceeds the normal value of the area. Off-trajectory measurements were also made from radiation lobes centered on radio bases with the sole purpose of verifying the possible existence of other points of discordance, not with a radiation pattern but with their close environment.
Thus, random routes were generated with a permanent measurement methodology with configurable alarm instrument, and it was particularized in density levels higher than 1 uW/cm2.
For the field measurements, both the TES-92 meter (which exclusively measures the emission in a range of 300 KHz–2.5 GHz) and the TM-190 meter that measures a range of 50 MHz–3.5 GHz of RNI were used. And additionally, it measures electromagnetic and electric field radiation separately in the frequency of 50 to 60 exclusively. The objective of this double measurement was to contrast the presence of abnormal values of electric fields in conditions of electromagnetic fields relevant to this study.
In informal measurements prior to the launch of the measurement campaign, 4 points were found where the level greatly exceeds the level of 1 uW/cm2, reaching values of 2.75 uW/cm2. That measurement campaign was launched with the aim of finding other points and analyzing the environmental conditions in order to establish a prediction pattern.
As a consequence of the aforementioned antecedents, the possibility arises that there are specific locations, or small areas where phenomena of increase in the level of radiation density are manifested that are not a consequence of the emission produced by antenna radiation, but of other factors which are related to the environment of the point in question.
There is sufficient evidence of the increase in light radiation at infrared frequencies and visible by the effects of the surfaces on which they affect, such as the case of Raman scattering. [14] When light interacts with matter, it can disperse inelastically from vibrational quantum states. During this process, the photons can lose energy, or gain it from vibratory excitations, and it can also produce a concomitant change in the scattered frequency. The phenomenon, called the Raman effect, was discovered experimentally in 1928 by C. V. Raman and K. S. Krishnan in India and, independently, by Leonid Mandelstam and Grigory Landsberg in the former Soviet Union.
Oldenburg SJ, Hale GD, Jackson JB, and Halas NJ postulate in their work Light scattering from dipole and quadrupole nanoshell antennas [15] that metal nanoshells are nanoscale optical components that allow the controllable redirection of electromagnetic radiation through a careful engineering of its multilayer structures. By varying the size of the core and the thickness of the shell of these nanoparticles, nanoscale “antennas” are constructed that can be selectively driven in a dipolar or quadrupole oscillation pattern. With spaced transverse sections many times larger than their physical cross-section, these antennas are efficiently coupled to the incident electromagnetic wave. These structures can focus, redirect, or divide incident light
In this sense, Martin Moskovits in his work Surface-Enhanced Spectroscopy [16] reveals that molecules adsorbed on specially prepared silver surfaces produce a Raman spectrum that is sometimes a million times more intense than expected. This effect was called improved surface Raman scattering (SERS). Since then, the effect has been demonstrated with many molecules and with several metals, including Cu, Ag, Au, Li, Na, K, In, Pt, and Rh.
Another factor that could be the cause of non-predictive patterns is stated in the work of Francisco J. Rodríguez-Fortuño, Giuseppe Marino, Pavel Ginzburg, Daniel O’Connor, Alejandro Martínez, and Gregory A. W, Near-Field Interference for the Unidirectional Excitation of Electromagnetic Guided Modes [17], where they postulate that wave interference is a fundamental manifestation of the superposition principle with numerous applications. Although in conventional optics, the interference between waves that experience different phase advances during propagation, the vector structure of the near field of an emitter is essential to control its radiation, since it interferes with the interaction with a mediating object. Then, the near-field interference of a circularly polarized dipole results in the unidirectional excitation of the electromagnetic modes guided in the near field, without a preferred far-field radiation direction.
With these studies, it can be postulated that in the vicinity of certain surfaces there may be abnormal concentrations of radiation with respect to a prediction based on the propagation models from a source based on an antenna and that there is a dependence of the characteristics of this abnormality with the polarization that occurs in the near field of the source, so not all antennas could produce constructive interferences.
Under this hypothesis is that a campaign of measurements focused on the probability of finding hot spots of radiation density in certain environmental conditions, in particular, metallic reflective surfaces or with reflective paints, is required.
It is a possibility that these points are the consequence of antennas or panels that have circular polarization characteristics, that is, discarding the linear polarization dipoles.
Although the emission should not be related to power lines, it is no less true that the process of transforming voltage with high power levels could generate harmonics that contribute to the emission, whose value could be a significant analysis of the presence of transformers in the vicinity of points of high radiation density.
Resolution ITU No P526-11 is a methodology that includes a series of predictive patterns taking into account a variety of effects of buildings on the radiation pattern by diffraction [18] and most other propagation models also take into account reflection effects. It is necessary to identify the presence of buildings with a differential height with respect to the normal level of buildings; in this sense, it will take into account only the buildings very close to the points of differential radiation of electromagnetic density.
For these purposes, a non-predictive non-ionizing radiation measurements protocol was designed.
In order to systematize the analysis of the environmental conditions that could eventually generate points with differential RNI levels, a working protocol was established based on the hypothesis that certain elements or constructive characteristics could be generating the points with radiation differentials with respect to normal radiation in the area.
A known radiation source of omnidirectional radiation must be determined in the UHF or higher bands whose radiation model is omnidirectional. To this end, the application Cell Network Info lite or similar should be used in an Android phone to locate the antenna on which the route will be based.
An analysis grid will be drawn identifying the route to be carried out. For this purpose, radial routes to the location of the tower should be prioritized.
A walking tour will be started by holding the TES 92 meter or similar in a hand at an approximate height of 1.60 meters above ground level, your own cell phone or any other device that can emit radiation (e.g., Bluetooth) must be deactivated.
The field analyst must observe the radiation indicator At all times looking for radiation patterns that exceed the normal nominal values of the area by 100% or more.
Upon the detection of a value such as stated above, proceed as follows:
The field analyst will stop or start a scan in the detailed area looking for the point where the maximum radiation is detected.
At that point, he will proceed to do the following:
Record the exact coordinates of the site.
Photograph the meter at that point.
Take the meter to a nearby point where the radiation level is significantly lower.
Record the coordinates of this point.
Photograph the meter in the foreground and in the background the place where the significant level was verified.
Return to the point where the significance was verified.
He will make an observation of the physical/constructive characteristics of the place, emphasizing the following aspects:
Constructions or parts of metal buildings both solid and grilled.
Metal signage nearby.
Surfaces that can be identified as reflective.
Metal gates.
Vehicles parked in the vicinity (in this case, check again when the vehicle is not).
Painted surfaces with some type of metallic or shiny paint.
Presence of obvious radiation sources (such as antennas, transformers, welding machines, electric motors in operation, generators, etc.).
viii. Any other aspect of the environment that is relevant.
He will photograph the surrounding environment and place particular focus on the constructions or elements listed.
Continue the journey under the rules stated.
Table 1 shows the values found taking into account the value of the point found and the value of its environment, obtaining the differential value. The table is ordered in descending order with respect to the differential.
From the analysis of Table 1, the following conclusions can be obtained:
The radius of a point of high differential radiation is variable and does not depend on the center’s RNI level.
The radiation differential between the maximum and the normal level is not directly related to the maximum level of radiation.
The observed average radius is 1.81 mts.
Table 2 is shown in order to determine the possible relationship between the proximity to the emission source and the points with the highest differential value of radiation density with respect to the normal values of the site.
ID site | Coordinates | Dif real-normal | Level l | Normal level | Radius (mts) |
---|---|---|---|---|---|
9-Rioja 880 | −24.76664, −65.39294 | 16.95 | 20.15 | 3.2 | 0.5 a 1 |
14-Avda. Independencia 1286 | −24.80827, −65.39923 | 16.14 | 17.64 | 1.5 | 4 |
8-Rioja 862 | −24.77988, −65.40314 | 7.71 | 8.51 | 0.8 | 0.4 a 0.9 |
12-Avda. Paraguay y J Castellanos | −24.80575, −65.4197 | 4.134 | 5.058 | 0.924 | 2 |
15-Avda. Independencia 1290 | −24.80828, −65.39889 | 4.05 | 5.25 | 1.2 | 3 |
7-Rioja 842 | −24.7813, −65.40111 | 2.859 | 3.599 | 0.74 | 0.9 a 1.5 |
4-Florida y San Luis | −24.77664, −65.40431 | 2.772 | 4.011 | 1.239 | 0.4 a 1 |
5-Florida 602 | −24.7796, −65.40132 | 2.609 | 3.223 | 0.614 | 0.3 a 07 |
Avda. Uruguay 735 | −24.7813, −65.40111 | 2.026 | 3 | 0.537 | 4 |
20-Mendoza “Lago del Parque” | −24.79541, −65.4028 | 1.602 | 3.152 | 1.55 | 2 |
16-Avda. Independencia 1326 | −24.80825, −65.39829 | 1.26 | 2.06 | 0.8 | 2 |
Avda. del Bicentenario 800 | −24.77988, −65.40314 | 1.19 | 2 | 0.33 | 5 |
25-Sarmiento y 12 de Octubre | −24.77378, −65.41483 | 1.161 | 1.791 | 0.63 | 1 |
18-Santa Fe y Mendoza | −24.79534, −65.4045 | 1.138 | 1.738 | 0.6 | 2 |
2-Santa Esq. Rioja | −24.76743, −65.39803 | 1.067 | 2.533 | 1.466 | 0.5 a 1 |
19-Mendoza 2 | −24.79551, −65.40302 | 0.935 | 1.735 | 0.8 | 3 |
Avda. Uruguay 895 | −24.7796, −65.40132 | 0.9 | 1 | 0.253 | 1 |
23-Aniceto Latorre y A. Güemes | −24.77307, −65.41625 | 0.883 | 1.57 | 0.687 | 1 |
22-San Martin Y Lavalle | −24.79374, −65.40344 | 0.85 | 1.45 | 0.6 | 3 |
26-Sarmiento y 12 de Octubre | −24.77416, −65.41455 | 0.811 | 1.261 | 0.45 | 2 |
Vicente López 1000 | −24.77664, −65.40431 | 0.81 | 1 | 0.22 | 4 |
24-Aniceto Latorre y A. Güemes | −24.77309, −65.41596 | 0.719 | 1.029 | 0.31 | 1 |
11-Lamadrid y Lola mora | −24.80426, −65.42133 | 0.7 | 1.3 | 0.6 | 1 |
Los Jazmines 840 | −24.76403, −65.3905 | 0.667 | 0.777 | 0.11 | 3 |
Avda. Uruguay 751 | −24.78087, −65.4012 | 0.663 | 0.955 | 0.292 | 2 |
Vicente López 1075 | −24.77694, −65.40427 | 0.621 | 0.934 | 0.313 | 2 |
6-Rioja 710 | −24.78087, −65.4012 | 0.601 | 1.141 | 0.54 | 0.5 a 1 |
Los Jazmines y Los Mandarinos | −24.76664, −65.39294 | 0.587 | 0.6 | 0.013 | 10 |
21-Mendoza “Paseo” | −24.79544, −65.40224 | 0.511 | 1.523 | 1.012 | 2 |
1-Santa Fe 698 | −24.76403, −65.3905 | 0.421 | 1.071 | 0.65 | 1 a 1.5 |
13-Avda. Independencia y calle Pucha | −24.80825, −65.40466 | 0.4 | 0.7 | 0.3 | 1 |
17-Avda. Independencia 1360 | −24.80827, −65.39797 | 0.3 | 0.5 | 0.2 | 2 |
Av. Reyes Católicos 1617 | −24.76743, −65.39803 | 0.294 | 0.535 | 0.241 | 1 |
3-Rioja Esq. Catamarca | −24.77694, −65.40427 | 0.21 | 0.89 | 0.68 | 0.3 a 0.7 |
Los Ombúes 95 | −24.76449, −65.39652 | 0.129 | 0.226 | 0.097 | 3 |
10-Jujuy 804 | −24.76449, −65.39652 | 0.06 | 0.61 | 0.55 | 0.4 a 0.8 |
Results of samples under non-predictive pattern measurement protocol.
Real-normal dif of S in | Theoretical radiation source (mts) |
---|---|
1695 | 100 |
1614 | 15 |
771 | 80 |
413.4 | 200 |
405 | 20 |
285.9 | 70 |
277.2 | 200 |
260.9 | 100 |
202.6 | 38 |
160.2 | 250 |
126 | 30 |
119 | 86 |
116.1 | 245 |
113.8 | 200 |
106.7 | 70 |
93.5 | 220 |
90 | 194 |
88.3 | 370 |
85 | 400 |
81.1 | 200 |
81 | 94 |
71.9 | 360 |
70 | 3 |
66.7 | 400 |
66.3 | 63 |
62.1 | 90 |
60.1 | 150 |
58.7 | 400 |
51.1 | 250 |
42.1 | 50 |
40 | 300 |
30 | 50 |
29.4 | 300 |
21 | 50 |
12.9 | 420 |
6 | 300 |
Differential radiation density values as a function of distance to probable source.
From Table 2 and Figure 16, it can be seen that there is no relationship between the increase in the differential of radiation and the distance to the most probable source of radiation since, for example, for a distance to the site of most likely emission of 100 meters, radiation differential values as different as 16.95 uW/cm2
Differential radiation density as a function of distance to probable source.
From Table 3 and Figure 17, it can be concluded that the presence of electrical distribution transformers does not constitute a conditioning factor for the point increase in the level of differential radiation density. However, the lack of influence in the specific increase cannot be guaranteed since they have an incidence of 27% in the total of events.
Real-normal differential | Proximity of transformers (mts) |
---|---|
16.95 | 1 |
16.14 | 0 |
7.71 | 1 |
4.134 | 0 |
4.05 | 0 |
2.859 | 1 |
2.772 | 0 |
2.609 | 0 |
2.026 | 0 |
1.602 | 0 |
1.26 | 1 |
1.19 | 1 |
1.161 | 0 |
1.138 | 0 |
1.067 | 0 |
0.935 | 0 |
0.9 | 0 |
0.883 | 0 |
0.85 | 0 |
0.811 | 0 |
0.81 | 0 |
0.719 | 0 |
0.7 | 1 |
0.667 | 0 |
0.663 | 0 |
0.621 | 0 |
0.601 | 0 |
0.587 | 0 |
0.511 | 0 |
0.421 | 0 |
0.4 | 0 |
0.3 | 1 |
0.294 | 0 |
0.21 | 1 |
0.129 | 1 |
0.06 | 1 |
Presence of distribution transformers in relation to differential level of radiation density.
Cases of presence of distribution transformers in relation to differential level of radiation density (y axis).
Incidence of the number of cases of metallic surfaces with respect to the differential of radiation density.
Distribution of probability of increase of differential level of radiation density according to the amount of metal surfaces nearby.
According to working hypothesis 4.3, the analysis of metal surfaces near points of high differential level of radiation density is of particular interest.
From Table 4, the following can be concluded:
Some surface 89%
Metal posters 27%
Metal gates 57%
Fences 68%
Differential real-normal | High metal signage cases | Metal gates cases | Metal fences/wiring cases | Number of cases |
---|---|---|---|---|
16.95 | 0 | 1 | 1 | 2 |
16.14 | 0 | 1 | 1 | 2 |
7.71 | 0 | 1 | 1 | 2 |
4.134 | 1 | 0 | 1 | 2 |
4.05 | 0 | 1 | 1 | 2 |
2.859 | 0 | 1 | 1 | 2 |
2.772 | 0 | 0 | 1 | 1 |
2.609 | 0 | 1 | 1 | 2 |
2.026 | 0 | 1 | 1 | 2 |
1.602 | 0 | 0 | 1 | 1 |
1.26 | 1 | 1 | 0 | 2 |
1.19 | 1 | 1 | 1 | 3 |
1.161 | 0 | 0 | 1 | 1 |
1.138 | 1 | 0 | 0 | 1 |
1.067 | 1 | 1 | 0 | 2 |
0.935 | 0 | 0 | 1 | 1 |
0.9 | 1 | 1 | 0 | 2 |
0.883 | 0 | 0 | 1 | 1 |
0.85 | 0 | 0 | 0 | 0 |
0.811 | 0 | 0 | 1 | 1 |
0.81 | 1 | 1 | 1 | 3 |
0.719 | 0 | 0 | 1 | 1 |
0.7 | 1 | 1 | 1 | 3 |
0.667 | 0 | 1 | 1 | 2 |
0.663 | 0 | 1 | 1 | 2 |
0.621 | 0 | 1 | 1 | 2 |
0.601 | 0 | 0 | 0 | 0 |
0.587 | 0 | 1 | 1 | 2 |
0.511 | 0 | 0 | 0 | 0 |
0.421 | 0 | 1 | 0 | 1 |
0.4 | 0 | 0 | 1 | 1 |
0.3 | 0 | 1 | 0 | 1 |
0.294 | 0 | 1 | 1 | 2 |
0.21 | 1 | 0 | 0 | 1 |
0.129 | 0 | 1 | 1 | 2 |
0.06 | 1 | 0 | 0 | 1 |
Closeness of billboard, gates, or metal fences with respect to the differential of radiation density.
The probability increases by 30% if there is more than one metal surface in the vicinity (Figure 18).
Having some type of metallic surface, there is an 89% chance of finding a point with radiation density differential (Figure 19).
From Table 5, the following can be concluded:
Some building 84%
Buildings of 2 floors 73%
Buildings of 3 floors or more 22%
Real-normal differential | 2-floor buildings | Buildings of 3 or more floors | Amount | Amount > 0 |
---|---|---|---|---|
16.95 | 1 | 0 | 1 | 1 |
16.14 | 1 | 0 | 1 | 1 |
7.71 | 1 | 0 | 1 | 1 |
4.134 | 1 | 1 | 2 | 1 |
4.05 | 1 | 0 | 1 | 1 |
2.859 | 1 | 0 | 1 | 1 |
2.772 | 1 | 1 | 2 | 1 |
2.609 | 1 | 0 | 1 | 1 |
2.026 | 1 | 0 | 1 | 1 |
1.602 | 1 | 0 | 1 | 1 |
1.26 | 1 | 0 | 1 | 1 |
1.19 | 0 | 1 | 1 | 1 |
1.161 | 0 | 0 | 0 | 0 |
1.138 | 0 | 0 | 0 | 0 |
1.067 | 1 | 0 | 1 | 1 |
0.935 | 1 | 0 | 1 | 1 |
0.9 | 1 | 0 | 1 | 1 |
0.883 | 0 | 1 | 1 | 1 |
0.85 | 0 | 0 | 0 | 0 |
0.811 | 0 | 0 | 0 | 0 |
0.81 | 1 | 1 | 2 | 1 |
0.719 | 0 | 1 | 1 | 1 |
0.7 | 1 | 0 | 1 | 1 |
0.667 | 1 | 0 | 1 | 1 |
0.663 | 1 | 0 | 1 | 1 |
0.621 | 1 | 0 | 1 | 1 |
0.601 | 1 | 0 | 1 | 1 |
0.587 | 1 | 0 | 1 | 1 |
0.511 | 0 | 0 | 0 | 0 |
0.421 | 1 | 0 | 1 | 1 |
0.4 | 1 | 0 | 1 | 1 |
0.3 | 1 | 0 | 1 | 1 |
0.294 | 0 | 1 | 1 | 1 |
0.21 | 1 | 0 | 1 | 1 |
0.129 | 1 | 0 | 1 | 1 |
0.06 | 1 | 1 | 2 | 1 |
Total | 27 | 8 | 31 |
Relationship between nearby buildings and the radiation level differential.
In 84% of the cases of differential increase in radiation density, there is a building with 2 or more floors nearby, although the presence of these two types of buildings only increases the possibility by 0.06%.
The following additional factors have been taken into account as a probable factor of point increase:
Influence of vegetation and trees
Pavement
Metallic ceilings
Electrical wiring
High density of parked vehicles
In this analysis, it is possible to deepen the point radiation according to its value.
From the analysis of Table 6, the following can be concluded:
Real-normal differential | High-density electrical wiring | High-density parked vehicles | Site under plants | Metal ceilings nearby |
---|---|---|---|---|
16.95 | 1 | 1 | 1 | 0 |
16.14 | 0 | 0 | 1 | 1 |
7.71 | 1 | 1 | 1 | 0 |
4.134 | 0 | 1 | 0 | 0 |
4.05 | 0 | 0 | 1 | 1 |
2.859 | 1 | 1 | 1 | 0 |
2.772 | 0 | 0 | 0 | 0 |
2.609 | 0 | 1 | 0 | 1 |
2.026 | 0 | 0 | 0 | 0 |
1.602 | 0 | 0 | 0 | 0 |
1.26 | 1 | 0 | 0 | 0 |
1.19 | 1 | 1 | 0 | 1 |
1.161 | 0 | 0 | 0 | 0 |
1.138 | 0 | 0 | 0 | 0 |
1.067 | 0 | 1 | 0 | 0 |
0.935 | 0 | 0 | 0 | 0 |
0.9 | 0 | 1 | 0 | 0 |
0.883 | 0 | 1 | 0 | 1 |
0.85 | 0 | 0 | 0 | 1 |
0.811 | 0 | 0 | 0 | 0 |
0.81 | 0 | 1 | 1 | 0 |
0.719 | 0 | 1 | 0 | 1 |
0.7 | 1 | 0 | 0 | 1 |
0.667 | 0 | 0 | 0 | 0 |
0.663 | 0 | 1 | 0 | 1 |
0.621 | 1 | 1 | 0 | 0 |
0.601 | 0 | 0 | 0 | 0 |
0.587 | 0 | 0 | 0 | 0 |
0.511 | 0 | 0 | 0 | 1 |
0.421 | 0 | 1 | 0 | 0 |
0.4 | 0 | 0 | 1 | 0 |
0.3 | 1 | 0 | 0 | 0 |
0.294 | 1 | 0 | 0 | 0 |
0.21 | 1 | 0 | 1 | 0 |
0.129 | 1 | 0 | 0 | 0 |
0.06 | 1 | 1 | 0 | 0 |
Influence of other factors on the increase in the difference in radiation density.
High levels:
63% cars
63% plants
38% roofs
Low levels:
34% cars
10% plants
24% ceilings
The presence of cars parked in the vicinity, plants or trees on the measurement area, and to lesser extent metal roofs have a strong influence on the point value, such that in the values above the average of 2.12 uW/cm2, the presence of these factors is verified. On the other hand, in low radiation values, there are no such conditions. Therefore, it can be concluded that vehicles and some types of plants contribute to the possibility of an increase in the level of radiation density.
It is also observed that at the highest levels there is the presence of two of these conditions.
There is no doubt that electromagnetic radiation has a number of variables whose study is constantly evolving, at the same time as technology evolves. New radiation patterns are incorporated to make the calculation more accurate and the behavior of electromagnetic waves more predictive.
In this work, it is demonstrated by field exploration in urban and suburban environments that there are points of high concentration of radiation, that these points have locations not related to the distance to the source, which are only points and not extensive areas with smaller radii than 4 meters, and that you can evaluate possibilities of existence of these points based on the surrounding environment, taking into account metallic surfaces at level and above ground level, constructions of more than one plant nearby, and to a lesser extent other factors, but in some cases, they are definitive in the location of what can be called hot spots of differential density of non-ionizing radiation.
The authors wish to express their gratitude to the Research Council of the Catholic University of Salta (UCASAL) for their support in the development of the research.
The authors declare that there is no potential conflict of interest related to the article.
Psoriasis is a chronic inflammatory skin disease that progresses with remission and exacerbations [1, 2]. It constitutes an important percentage, approximately 6–8% of patients who apply to dermatology clinics [3]. Due to its high prevalence and chronic course, it is important to diagnose it early and clearly to manage patient appropriately and avoid functional losses as much as possible. In addition, in some situations that should be intervened swiftly such as erythrodermic psoriasis or generalized pustular psoriasis; the sooner we diagnose, the better we take control of disease setting.
In diagnosis of psoriasis, usually clinical observation is enough; however, in doubtful cases, histopathological examination is required as gold standard technique. However, it requires an invasive procedure and needs time for pathological preparation. With dermoscopy, we can mostly distinguish psoriasis from other resembling diseases in clinic noninvasively. Despite it not being gold standard, easily applicable and noninvasive properties of dermoscopy make it a helpful diagnostic tool and reduce the need of performing biopsies.
Plaque psoriasis is the most common clinical subtype of psoriasis with 90% of all cases [4]. It is characterized by erythematous, well-defined, and usually indurated plaques greater than 1 cm in size with white-silvery scales on them (Figure 1). They can vary in size and may coalesce. Especially rapidly progressing lesions can be seen in annular configuration (Figure 2) [4, 5]. Removal of psoriatic scales may cause pinpoint bleedings, which is called Auspitz sign. Psoriatic plaques are mostly located in the scalp, trunk, lumbosacral area, and extensor surfaces of extremities (Figure 3) [6].
Erythematous, well-defined indurated plaque with white scales.
Erythematous, annular plaques with white scales.
Psoriatic plaques located on the trunk and extensor surfaces of the arms.
Dermoscopic examination of a psoriasis plaque should be done in three categories: background, vessels, and scales. Examination should be done with minimal pressure to visualize vessels better and with immersion oil if possible.
In dermoscopic examination of plaque psoriasis with handheld dermoscope, we usually see regularly distributed dotted vessels in a reddish-pinkish background and white scales (Figure 4) [7]. In some cases, background can be grayish-white due to highly hyperkeratotic scales (Figure 5).
Regularly distributed dotted vessels on reddish background with patchy distributed white scales. Note dot blood hemorrhages (red circle). Anatomical localization: Upper extremity (×10).
Background color can barely be seen due to diffuse thick white scales. Dotted vessels can be seen in the center. Note dot blood hemorrhages (red circle). Anatomical localization: Elbow (×10).
Apart from regular distribution, vessels can be distributed scattered, in clusters, in rings, and patchy (Figure 6a). In higher magnifications (with videodermoscopy), these dotted vessels can be seen as bushy capillaries, globules, radial capillaries, globular rings, hairpin capillaries, and comma vessels in descending order [8] (Figure 6b). Rarely dot blood hemorrhages can be seen in vessel locations (Figure 5). Scales can be distributed diffuse, patchy, central, or peripheral in descending order; however, white color is key point for scales [8, 9].
a: Vessel distribution patterns (regular, scattered, in clusters, in rings, patchy, respectively). b: Vessels subtypes can be seen in higher magnifications (bushy, globular, radial, globular ring, hairpin, and comma vessels, respectively).
Differential diagnosis of plaque psoriasis should be done with skin diseases, which are characterized by erythematous plaques with scales such as dermatitis, tinea corporis, pityriasis rosea, pityriasis rubra pilaris, lichen planus, and non-pigmented squamous cell carcinoma in situ.
In dermoscopic examination of dermatitis, we usually see patchy or scattered distributed dotted vessels with yellow globules (corresponding to sero-crusts) [10]. Background can be erythematous or not depending on lesions phase (acute or chronic). Hemorrhagic crusts can be seen as well secondary to traumatization (Figure 7).
Yellow globules, dot blood hemorrhages, and hemorrhagic crusts, patchy distributed dotted vessels (red circle). Background is slightly pinkish. Anatomical localization: Lower extremity (×20).
In dermoscopic examination of tinea corporis, we usually see peripherally located dotted vessels and rough white scales (Figure 8). In contrast with psoriasis, dotted vessels are not regularly distributed and not uniform. In addition, scales are only located peripherally, tend to peel outward, and shaped in moth-eaten pattern [11].
Peripherally located dotted vessels and white scales. Note the moth-eaten pattern (red circle). Anatomical localization: Trunk (×10).
Pityriasis rubra pilaris shows dotted and more frequently linear vessels, perifollicular yellow-orange halos, follicular plugs with central hair on them (Figure 9). Scales can be yellowish or whitish. Background is usually dark or yellowish red [7, 12].
Dotted vessels regularly distributed on pinkish background. Note the follicular plugs and central hairs (red circles). Anatomical localization: Elbow (×20).
Squamous cell carcinoma in situ and psoriasis can be challenging especially in solitary plaques. Dermoscopic clues for non-pigmented squamous cell carcinoma in situ are dotted or glomerular vessels in clusters in the center and arranged in lines at the periphery with yellowish white scales (Figure 10) [13, 14].
Glomerular vessels in the center, white scales. Note the linear arrangement of dotted vessels at the periphery (red circles) and actinic keratosis area at top left. Anatomical localization: Forearm (×20).
Dermoscopic features of plaque psoriasis and its differentials are summarized in Table 1.
Background | Vessel types | Vessel arrangement | Scales | Additional features | |
---|---|---|---|---|---|
Reddish-pinkish Whitish (due to hyperkeratotic scales) | Dotted | Regular | Whitish-grayish | ||
Skin colored-pinkish | Dotted | Scattered/patchy | Yellowish | Irregularly distributed dot blood hemorrhages due to traumatization | |
Reddish | Dotted | Peripheral | White and rough; peripheral; moth-eaten pattern; tend to peel outwards | ||
Dark red/yellowish red | Linear and/or dotted | Scattered | Yellowish-whitish; follicular | Perifollicular yellow-orange halos, follicular plugs, central hair | |
Pinkish | Glomerular or dotted | Regularly in center, may organize in lines at the periphery | Yellowish white scales | Peripheral actinic keratosis areas may help (white and wide follicular openings, rosettes) |
Dermoscopic features of plaque psoriasis and its differentials.
Guttate psoriasis, a psoriasis variant that is more common in pediatric population and young adults. Distinctly from other variants, we know that guttate psoriasis is selectively triggered by beta hemolytic streptococcal infections [15]. It is characterized by erythematous, well-defined flat papules/plaques lower than 1 cm in size with white-silvery scales on them. Lesions mostly located in the trunk and extremities (Figure 11a and b).
a: Slightly erythematous flat papules/plaques with white scales on them in an adolescent. Trunk localization. b: Slightly erythematous flat papules/plaques with white scales on them in an adolescent. Extremity localization.
Dermoscopic features of guttate psoriasis are very similar with plaque psoriasis, which is characterized by regularly distributed dotted vessels in a reddish background and white scales on them (Figure 12). Due to guttate psoriasis’ smaller lesion sizes (lower than 1 cm in diameter), findings may be insignificant when compared with plaque psoriasis (Figure 13).
Regularly distributed dotted vessels in reddish background. White scales. Anatomical localization: Upper extremity (×10).
Regularly distributed dotted vessels on pinkish background. Scales are white, thin, and patchy. Anatomical localization: Upper extremity (×10).
Differential diagnosis of guttate psoriasis should be done with skin diseases, which are characterized by erythematous papules/small plaques with scales. Pityriasis rosea, lichen planus, nummular dermatitis, secondary syphilis, tinea corporis, pityriasis lichenoides chronica, and disseminated eruptive porokeratosis may count as differential. (Dermatitis and tinea corporis will not be mentioned because they were discussed above.)
Dermoscopic examination of pityriasis rosea shows irregular distributed dotted vessels and peripheral thin white scale (Figure 14) [10]. Scales tend to peel outward as in tinea corporis. But note the white scale is not rough and vessels are not in the same distribution with scales. Background is generally skin-colored or slightly pinkish.
Patchy distributed dotted vessels and peripheral thin white scale. The configuration of the scales named “collarette sign.” anatomical localization: Back (×10).
In dermoscopic examination of lichen planus, key point is detecting Wichkam striaes, which cannot be seen macroscopically sometimes. In fair-skinned patients, dotted and linear vessels around Wickham striae make these structures more visible (Figure 15); however, in dark-skinned patients, absence of peripheral vascular structures around Wichkam striaes may lead to misdiagnosis [16].
Reticular arranged white lines (Wickham striae). Note the dotted vessels around Wickham striae in this fair-skinned patient. Anatomical localization: Lower extremity (×10).
In dermoscopic examination of secondary syphilis, yellowish-orange background and absence of vascular structures are key points (Figure 16) [17]. Scales may be present, however, thinner and smaller when compared with psoriatic scales.
Yellowish-orange structureless area with thin white scales. Note the absence of vascular structures. Anatomical localization: Back (×10).
In dermoscopic examination of pityriasis lichenoides chronica, we usually see orange-yellowish structureless areas and focally distributed dotted or linear vessels (Figure 17) [18].
Yellowish-orange structureless areas with thin white scales. Note the focal dotted vessel areas (red circles). Anatomical localization: Hand dorsum (×10).
In dermoscopic examination of porokeratosis, key clue is peripheral double lines resembling railways (Figure 18). This feature is called “cornoid lamella” [19].
Small white scales on yellowish-brown background. Note the railway-like “cornoid lamella” at the periphery (red arrows). Anatomical localization: Hand dorsum (×10).
Dermoscopic features of guttate psoriasis and its differentials are summarized in Table 2.
Background | Vessel types | Vessel arrangement | Scales | Additional features | |
---|---|---|---|---|---|
Reddish-pinkish | Dotted | Regular | Whitish-grayish, thin and small | ||
Pinkish | Dotted (vascularization is not dominant) | Patchy | White, thin, peripheral and tend to peel outwards “collarette sign” | ||
Pinkish, violaceus | Dotted or absent | Aroud Wickham striae | Whitish, patchy distributed, thin and small | ||
Yellowish-orange | Absent | White and thin | |||
Pinkish, yellowish-orange | Dotted or linear | Focal | White, patchy, thin | ||
Yellowish-brown | Unsignificant | White, small | Peripheral railway like double lines called “cornoid lamella” |
Dermoscopic features of guttate psoriasis and its differentials.
Inverse psoriasis is another clinical variant of psoriasis, which involves flexural areas such as axillary, inguinal, and inframammary [20]. The prevalence of inverse psoriasis is not clear and varies in 3–36% because of diagnostic challenges [21]. And also it is controversial that if genital involvement is a part of inverse psoriasis; however, we include genital involvement under this topic for convenience of expression.
Inverse psoriasis is typically present with well-defined erythematous plaques located in flexural areas (Figure 19a and b). It can present with or without typical psoriasis plaques. In contrast with plaque and guttate psoriasis, scales are insignificant or absent.
a: Erythematous plaque located in inframammary fold. b: Erythematous papules and plaques located in axillary fold. Note peripheral lesions have mild white scales.
Genital involvement shares similar clinical features with inverse psoriasis such as well-defined erythematous papules and plaques (Figure 20). However, occlusion in the genital areas is not as much as flexural areas, scales could be more visible in the genitals.
Coalesced erythematous papules located in the glans penis and penile dorsum.
Dermoscopic features of inverse psoriasis are characterized by regularly distributed dotted vessels on reddish background (Figure 21). In contrast with other variants, scales are absent. Absence of scales enhances visualization of vascular structures. Consequently, dermoscopic differential diagnosis of flexural dermatosis mainly leans on evaluation of vascular structures.
Regularly distributed dotted vessels on pinkish background. Anatomical localization: Inframammary (×10).
Differential diagnosis of inverse psoriasis should be done with skin diseases, which present with erythematous patches/plaques in flexural and genital areas. Mechanical intertrigo, seborrheic dermatitis, lichen planus inversus, and fungal/bacterial infections may count as differential. Because no clear dermoscopic features have been defined for mechanical intertrigo and flexural infections, we will discuss dermoscopic features of seborrheic dermatitis and lichen planus inversus under this topic.
The main dermoscopic features of seborrheic dermatitis of flexural areas are irregularly distributed linear, blurry vessels [22]. As we mentioned before, we do not see classical yellowish scales of seborrheic dermatitis in flexuras.
When we review the literature so far, there are only three reports about dermoscopic features of lichen planus inversus. In all of these reports, dermoscopic features of only pigmented variant of lichen planus inversus were evaluated and defined as diffuse brown patches containing multiple granular gray-brown dots [23, 24, 25]. In our clinical practice, we see non-pigmented lichen planus inversus more than pigmented subtype. According to our dermoscopic experience, Wickham striae, which is seen in lichen planus inversus, tends to be in “starry sky” or “radial streaming” pattern rather than reticular pattern. Background is usually pinkish or violaceous. Dotted vessels usually encircle Wickham striae (Figure 22).
Wickham striae in “radial streaming” pattern (red circle) and “starry sky” pattern (blue circle). Dotted vessels surround Wickham striae in a patchy arrangement. Anatomical localization: Intermammary (×10).
Dermoscopic features of inverse psoriasis and its differentials are summarized in Table 3.
Background | Vessel types | Vessel arrangement | Additional features | |
---|---|---|---|---|
Reddish-pinkish | Dotted | Regular | ||
Pinkish | Linear, blurry vessels | Irregular | ||
Pinkish, violaceus | Dotted or absent | Aroud Wickham striae | According to our dermoscopic experience, Wickham striae, which is seen in lichen planus inversus, tends to be in “starry sky” or “radial streaming” pattern |
Dermoscopic features of inverse psoriasis and its differentials.
Pustular psoriasis is a rare clinical variant of psoriasis, which is characterized by sterile pustules on an erythematous skin (Figure 23). It could be either local or generalized [26]. In generalized pustular psoriasis, concomitant fever, malaise, dehydration may also be present [27].
Small pustules and lake of pus on erythematous background.
Dermoscopic features of pustular psoriasis are characterized by regularly distributed dotted vessels with milky globules (corresponding to sterile pustules) on reddish background (Figure 24) [28]. Attention should be paid on non-follicular localization of pustules. Typical vascular structures are seen. Nonspecific yellow crust may be seen. Dermoscopic features are same in both localized and generalized subtypes.
Milky globules and regularly distributed dotted and bushy vessels on reddish background in pustular psoriasis. Anatomical localization: Trunk (×10).
Dermoscopic differential diagnosis of pustular psoriasis should be done with acute generalized exanthematous pustulosis (AGEP). In life-threatening clinical conditions such as generalized pustular eruptions, rapid and right diagnosis is essential, and dermoscope is very helpful at that point. In both pustular psoriasis and AGEP, pustules are sterile, disseminated, may coalesce, and be non-follicular. Thereby, we cannot distinguish these two situations by their clinical view only. In dermoscopic examination of both pustular psoriasis and AGEP, non-follicular milky globules on reddish background are seen [28]. Discriminately, in pustular psoriasis we see regularly distributed dotted vessels (Figure 24). In dermoscopic examination of AGEP, background is usually pinkish and vascular structures are absent (Figure 25) [29].
Milky globules on reddish background. Globules are non-follicular (red circle). Note the absence of vessels. Anatomical localization: Trunk (×10).
Erythroderma is a life-threatening condition, which is defined as desquamation and erythema of more than 90% of body surface area [30]. Erythrodermic variant of psoriasis (Figure 26) generally occurs due to poor control of disease, withdrawal of anti-psoriatic treatments, triggering drug intake, underlying systemic infections or conditions [31]. Clinical clues for erythrodermic psoriasis diagnosis are known history of psoriasis, psoriatic nail changes, presence of psoriatic arthritis. However, if none of the mentioned features is present, dermoscopy could be a game-changer.
Desquamation and erythema of all body surfaces.
Dermoscopic features of erythrodermic psoriasis are the same as other psoriasis variants. Regularly distributed dotted vessels on a reddish background, and patchy white scales are seen (Figure 27) [32].
Regularly distributed dotted vessels and white scales. Anatomical localization: Lower extremity (×20).
Dermoscopic differential diagnosis of erythrodermic psoriasis includes dermatosis that can present with erythroderma such as atopic dermatitis, mycosis fungoides, and pityriasis rubra pilaris (Pityriasis rubra pilaris will not be mentioned because it was discussed above.)
Dermoscopic examination of atopic dermatitis shows typical dermatitis features. Yellowish globules (corresponding to sero-crusts) and patchy distributed dotted vessels on a pinkish background are demonstrative (Figure 28) [32].
Yellow globules, patchy distributed dotted vessels. Background is slightly pinkish. Tiny white scales are also present. Tiny white scales correspond to desquamation areas. Anatomical localization: Trunk (×10).
Dermoscopic features of erythrodermic mycosis fungoides are a combination of linear and dotted vessels on a pale pinkish background (Figure 29) [32]. Some short linear vessels may be curved and named as “spermatozoon-like” vessels.
Linear, serpiginous, and dotted vessels on pinkish background. Tiny white scales correspond to desquamation areas. Anatomical localization: Trunk (×10).
Dermoscopic features of erythrodermic psoriasis and its differentials are summarized in Table 4.
Background | Vessel types | Vessel arrangement | Scales | Additional features | |
---|---|---|---|---|---|
Reddish | Dotted | Regular | White, scattered-patchy scales | ||
Pinkish | Dotted | Patchy | Yellowish sero-crusts | ||
Pinkish (pale) | Linear and dotted | Scattered | Whitish scales can present. | . |
Dermoscopic features of erythrodermic psoriasis and its differentials.
Psoriasis is a common skin disease with different clinical presentations. Generally, clinical evaluation is enough for diagnosis, though dermoscope is a helpful and noninvasive examination technique that enhances true diagnosis ratio. Knowing psoriasis’ and its differentials’ dermoscopic features may reduce requirement for histopathological examination and also makes rapid diagnosis possible in life-threatening conditions such as erythroderma. Note that regularly distributed dotted vessels on a reddish background are the most important clues for any variant of psoriasis. In doubtful cases, histopathological examination should be done for verifying the diagnosis as a gold standard technique.
All photos used in this chapter were taken by Dr. Ece Gokyayla with iPhone (XS) and dermatoscope (DermLite, DL4 model, 3Gen, USA) connected to an iPhone (XS) via adapter (DermLite Connection Kit MagnetiConnect). Immersion oil was not used.
The authors declare no conflict of interest and no funding source.
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",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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In food industries, nanoparticles are leading in forming the food with high quality and good nutritive value.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Alaa Y. Ghidan and Tawfiq M. Al Antary",authors:null},{id:"68760",doi:"10.5772/intechopen.88744",title:"Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers",slug:"nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers",totalDownloads:1291,totalCrossrefCites:5,totalDimensionsCites:16,abstract:"Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. 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In this section, the oxidation of cyclohexane (CH) and benzyl alcohol (BA) to adipic acid (AA), benzaldehyde (BAl), and ammoxidation of 2-methylpyrazine to 2-cyanopyrazine are discussed. Finally, Section 6 describes, main points and outlook are summarized.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Ahmad Alshammari and Venkata Narayana Kalevaru",authors:[{id:"178547",title:"Dr.",name:"Ahmad",middleName:null,surname:"Alshammari",slug:"ahmad-alshammari",fullName:"Ahmad Alshammari"},{id:"180753",title:"Dr.",name:"V. Narayana",middleName:null,surname:"Kalevaru",slug:"v.-narayana-kalevaru",fullName:"V. Narayana Kalevaru"}]},{id:"50852",doi:"10.5772/63729",title:"Synthesis of Gold Nanoparticles Using Amino Acids by Light Irradiation",slug:"synthesis-of-gold-nanoparticles-using-amino-acids-by-light-irradiation",totalDownloads:3622,totalCrossrefCites:3,totalDimensionsCites:10,abstract:"The synthesis of nanoparticles is generally carried out by chemical reduction, which is effective but uses a number of toxic substances, making the process potentially harmful to the environment. Thus, as part of the search for environmentally friendly or green synthetic methods, this chapter aimed to present the synthesis of gold nanoparticles (AuNPs) using only HAuCl4, Milli-Q water, white light from a xenon lamp, and amino acids. A total of 21 amino acids were studied, and the shapes and sizes of the resultant nanoparticles were evaluated. The products were characterized by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy, zeta potential measurements, and transmission electron microscopy. The synthesis of the AuNPs was successful with 18 amino acids, and the best results were obtained with aspartic acid, arginine, threonine, tryptophan, and valine. The nanoparticles were spherical and their sizes ranged from 5 to 100 nm. Changes in pH were required to improve the stability of the colloidal suspensions.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Lilia Coronato Courrol and Ricardo Almeida de Matos",authors:[{id:"183894",title:"Ph.D.",name:"Lilia",middleName:null,surname:"Courrol",slug:"lilia-courrol",fullName:"Lilia Courrol"},{id:"185446",title:"MSc.",name:"Ricardo",middleName:null,surname:"Matos",slug:"ricardo-matos",fullName:"Ricardo Matos"}]},{id:"72461",doi:"10.5772/intechopen.92796",title:"Role of Nanobiotechnology in Drug Discovery, Development and Molecular Diagnostic",slug:"role-of-nanobiotechnology-in-drug-discovery-development-and-molecular-diagnostic",totalDownloads:1079,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"Nano-biotechnology has already tested its magnitude in a number of sections of existence science and biotechnology field. It is no longer hyperbole to say that in future, nano-scale method would in reality take the associated science area to the subsequent level. Since, there are technical hurdles present; despite the fact that scientists are giving their great to overcome such problems. Applications of nano-biotechnology have already been discussed in this chapter. Future potential are really associated with innovative amendment of such applications. Despite of some impedance, this technology presents giant hope in the future. It performs most important position in distinct sorts of biomedical application such as shipping of drug, gene therapy, biosensors, biomarkers and molecular imaging. It additionally leads to innovations in this field. The fundamental lookup goal of this discipline would be the innovation of early analysis approach and cure with target-specific remedy therapy. Although there would possibly be some safety worries with admire to the in vivo use of nanoparticles, research are in region to decide the nature and extent of adverse events.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Deepak Kumar Dash, Rajni Kant Panik, Anil Kumar Sahu and Vaibhav Tripathi",authors:[{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu"},{id:"250558",title:"Dr.",name:"Deepak Kumar",middleName:null,surname:"Dash",slug:"deepak-kumar-dash",fullName:"Deepak Kumar Dash"},{id:"314683",title:"Dr.",name:"Rajnikant",middleName:null,surname:"Panik",slug:"rajnikant-panik",fullName:"Rajnikant Panik"},{id:"316679",title:"Dr.",name:"Vaibhav",middleName:null,surname:"Tripathi",slug:"vaibhav-tripathi",fullName:"Vaibhav Tripathi"}]}],mostDownloadedChaptersLast30Days:[{id:"68970",title:"Applications of Nanotechnology in Agriculture",slug:"applications-of-nanotechnology-in-agriculture",totalDownloads:3546,totalCrossrefCites:8,totalDimensionsCites:21,abstract:"Nanotechnology has gained intense attention in the recent years due to its wide applications in several areas like medicine, medical drugs, catalysis, energy and materials. Those nanoparticles with small size to large surface area (1–100 nm) have several potential functions. These days, sustainable agriculture is needed. The development of nanochemicals has appeared as promising agents for the plant growth, fertilizers and pesticides. In recent years, the use of nanomaterials has been considered as an alternative solution to control plant pests including insects, fungi and weeds. Several nanomaterials are used as antimicrobial agents in food packing in which several nanoparticles such as silver nanomaterials are in great interest. Many nanoparticles (Ag, Fe, Cu, Si, Al, Zn, ZnO, TiO2, CeO2, Al2O3 and carbon nanotubes) have been reported to have some adverse effects on plant growth apart from the antimicrobial properties. In food industries, nanoparticles are leading in forming the food with high quality and good nutritive value.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Alaa Y. Ghidan and Tawfiq M. Al Antary",authors:null},{id:"72461",title:"Role of Nanobiotechnology in Drug Discovery, Development and Molecular Diagnostic",slug:"role-of-nanobiotechnology-in-drug-discovery-development-and-molecular-diagnostic",totalDownloads:1079,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"Nano-biotechnology has already tested its magnitude in a number of sections of existence science and biotechnology field. It is no longer hyperbole to say that in future, nano-scale method would in reality take the associated science area to the subsequent level. Since, there are technical hurdles present; despite the fact that scientists are giving their great to overcome such problems. Applications of nano-biotechnology have already been discussed in this chapter. Future potential are really associated with innovative amendment of such applications. Despite of some impedance, this technology presents giant hope in the future. It performs most important position in distinct sorts of biomedical application such as shipping of drug, gene therapy, biosensors, biomarkers and molecular imaging. It additionally leads to innovations in this field. The fundamental lookup goal of this discipline would be the innovation of early analysis approach and cure with target-specific remedy therapy. Although there would possibly be some safety worries with admire to the in vivo use of nanoparticles, research are in region to decide the nature and extent of adverse events.",book:{id:"9012",slug:"applications-of-nanobiotechnology",title:"Applications of Nanobiotechnology",fullTitle:"Applications of Nanobiotechnology"},signatures:"Deepak Kumar Dash, Rajni Kant Panik, Anil Kumar Sahu and Vaibhav Tripathi",authors:[{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu"},{id:"250558",title:"Dr.",name:"Deepak Kumar",middleName:null,surname:"Dash",slug:"deepak-kumar-dash",fullName:"Deepak Kumar Dash"},{id:"314683",title:"Dr.",name:"Rajnikant",middleName:null,surname:"Panik",slug:"rajnikant-panik",fullName:"Rajnikant Panik"},{id:"316679",title:"Dr.",name:"Vaibhav",middleName:null,surname:"Tripathi",slug:"vaibhav-tripathi",fullName:"Vaibhav Tripathi"}]},{id:"51930",title:"Gold-Catalysed Reactions",slug:"gold-catalysed-reactions",totalDownloads:1949,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"In recent years, there have been three significant pieces of research which helped propel gold catalysis research into the forefront: the discoveries that gold/silica can catalyse the hydrogenation of pentene, that gold on carbon can be used in the hydrochlorination of acetylene and that deposition-precipitation (DP) methods can be used to prepare nanogold on titania capable of enabling the oxidation of CO at very low temperatures. The synthesis of small gold particles, their characterisation and peculiar properties are considered together with their behaviour as heterogeneous catalysts for a variety of reactions. Some of the issues concerning the practical application of gold catalysts are also discussed.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"J.A. Moma, T.A. Ntho and Michael Scurrell",authors:[{id:"179872",title:"Prof.",name:"Mike",middleName:null,surname:"Scurrell",slug:"mike-scurrell",fullName:"Mike Scurrell"},{id:"183973",title:"Dr.",name:"John",middleName:null,surname:"Moma",slug:"john-moma",fullName:"John Moma"},{id:"183974",title:"Dr.",name:"Thabang",middleName:"Abraham",surname:"Ntho",slug:"thabang-ntho",fullName:"Thabang Ntho"}]},{id:"52066",title:"Supported Gold Nanoparticles as Promising Catalysts",slug:"supported-gold-nanoparticles-as-promising-catalysts",totalDownloads:3108,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"In recent times, gold nanoparticles (AuNPs) either in the form of colloids or as supported nanoparticles are being extensively used as efficient redox catalyst materials. Catalysis particularly using supported gold nanoparticles (AuNPs) has attracted immense research interest due to their unique properties and greater potentiality that is directly related to their particle size. The primary objective of this chapter is to provide comprehensive overview about gold metal nanoparticles (AuNPs) and their application as promising catalysts. This chapter contains six sections in total. Section 1 starts with a general introduction, recent progress, and brief summary of the application of supported AuNPs as promising catalysts for different applications. Section 2 briefs the properties and stability of gold nanoparticles. Section 3 reviews the preparation methods of supported AuNPs for a wide range of catalytic applications. Section 4 describes briefly some of the most commonly reported supported AuNPs for different applications. Section 5 concentrates on our own results related to the application of supported AuNPs in heterogeneous catalysis. In this section, the oxidation of cyclohexane (CH) and benzyl alcohol (BA) to adipic acid (AA), benzaldehyde (BAl), and ammoxidation of 2-methylpyrazine to 2-cyanopyrazine are discussed. Finally, Section 6 describes, main points and outlook are summarized.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Ahmad Alshammari and Venkata Narayana Kalevaru",authors:[{id:"178547",title:"Dr.",name:"Ahmad",middleName:null,surname:"Alshammari",slug:"ahmad-alshammari",fullName:"Ahmad Alshammari"},{id:"180753",title:"Dr.",name:"V. Narayana",middleName:null,surname:"Kalevaru",slug:"v.-narayana-kalevaru",fullName:"V. Narayana Kalevaru"}]},{id:"50852",title:"Synthesis of Gold Nanoparticles Using Amino Acids by Light Irradiation",slug:"synthesis-of-gold-nanoparticles-using-amino-acids-by-light-irradiation",totalDownloads:3621,totalCrossrefCites:3,totalDimensionsCites:10,abstract:"The synthesis of nanoparticles is generally carried out by chemical reduction, which is effective but uses a number of toxic substances, making the process potentially harmful to the environment. Thus, as part of the search for environmentally friendly or green synthetic methods, this chapter aimed to present the synthesis of gold nanoparticles (AuNPs) using only HAuCl4, Milli-Q water, white light from a xenon lamp, and amino acids. A total of 21 amino acids were studied, and the shapes and sizes of the resultant nanoparticles were evaluated. The products were characterized by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy, zeta potential measurements, and transmission electron microscopy. The synthesis of the AuNPs was successful with 18 amino acids, and the best results were obtained with aspartic acid, arginine, threonine, tryptophan, and valine. The nanoparticles were spherical and their sizes ranged from 5 to 100 nm. Changes in pH were required to improve the stability of the colloidal suspensions.",book:{id:"5310",slug:"catalytic-application-of-nano-gold-catalysts",title:"Catalytic Application of Nano-Gold Catalysts",fullTitle:"Catalytic Application of Nano-Gold Catalysts"},signatures:"Lilia Coronato Courrol and Ricardo Almeida de Matos",authors:[{id:"183894",title:"Ph.D.",name:"Lilia",middleName:null,surname:"Courrol",slug:"lilia-courrol",fullName:"Lilia Courrol"},{id:"185446",title:"MSc.",name:"Ricardo",middleName:null,surname:"Matos",slug:"ricardo-matos",fullName:"Ricardo Matos"}]}],onlineFirstChaptersFilter:{topicId:"44",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:754,paginationItems:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",biography:"Dr. Pravin Kendrekar, MSc, MBA, Ph.D., is currently a visiting scientist at the Lipid Nanostructure Laboratory, University of Central Lancashire, England. He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. 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