Brucellosis is one of the most common and economically important zoonotic diseases globally. Office International des Epizooties (OIE) listed it as the second most important zoonotic disease. The disease affects almost all animals but importantly buffalo. The disease manifests itself in the form of abortion, still births, weak calves, infertility, and specific lesions on reproductive organs. It is prevalent worldwide but still a neglected disease. As a zoonotic disease its importance is multifarious for animals as well as public health. Taking into account poor health facilities and unawareness, its control becomes very significant. The difficulty to treat this disease and its zoonotic potential compel slaughtering as a best strategy to get rid of this disease. There are not too many therapeutic trials conducted to control bovine brucellosis. Instead many therapeutic trials have been conducted for treating human brucellosis. The therapeutic trial requires long term administration of drugs (almost 6 weeks) without any surety of complete recovery so it is a preferred practice to eradicate the animal or sell it out instead of treating.
- therapeutic trial
Brucellosis is one of the most common and economically important zoonotic diseases globally . It was first discovered by Bruce in 1887. It is also known as undulant fever, Mediterranean fever, Epizootic abortion, Enzootic abortion, Malta fever, and Bang’s disease [2, 3]. It is considered as the most rapidly spreading disease by the World Health Organization (WHO), Food and Agriculture Organization (FAO), and Office International des Epizooties (OIE) . Significant economic losses due to brucellosis are abortion, low milk yield, low conception rate and culling of animal . Central Asia, the Middle East and adjacent subtropical geographies are among those with the highest incidence of brucellosis among humans and livestock worldwide . There is a reason to believe that the burden caused by brucellosis in low-income countries in Asia and Africa is large . Important animal species that can get this disease include cattle, buffalo, swine, sheep, goats, camels, dogs and being zoonotic can also infect humans . Prevalence of brucellosis in Buffalo is 5.05% in Pakistan . This is suggested by quite an old study and conduction of a new research is required to study the current trends of brucellosis in Pakistan. It is for sure that its prevalence has increased to threatening level.
2. Diagnosis of brucellosis
ELISA and PCR are more specific tests to diagnose brucellosis but there are various limitations to these tests. Both of these tests are expansive and need sophisticated equipment to perform. Both cannot be performed in field conditions.
2.1 Therapeutic trial of brucellosis
The bovine brucellosis is very prevalent but a neglected disease on the whole. The countries which are declared as
Alavi and Ali Reza treated
Hari and Sughanda conducted a different type of research and checked immunotherapeutic response in cattle using a specific biomarker. They are against brucellosis. The SL induced strong antibody response and RL reported successful use of phage lysates of RB51 (RL) and S19 (SL) against brucellosis. The SL induced strong antibody response and RL stimulated cell mediated immunity (CMI). Other than these, no therapeutic trial are available in literature for evaluation. The reasons of which have already been discussed.
Although bovine brucellosis is very prevalent and now reemerging still no therapeutic trial has been conducted since now. The main reasons behind include the complex nature of
This chapter is supported by PAK US Science and Technology project entitled “Capacity building for vector born neglected diseases in livestock.”
Conflict of interest
The authors declare that there is no conflict of interest regarding the use of this data.
|OIE||Office International des Epizooties|
|WHO||World Health Organization|
|FAO||Food and Agriculture Organization|
|FPA||fluorescence polarization assays|
|CMI||cell mediated immunity|
|RBPT||Rose Bengal plate test|
|STAT||standard tube agglutination test|
|CFT||complement fixation test|
|ELISA||enzyme linked immunosorbant assay|
|PCR||polymerase chain reaction|
Godfroid J, Nielsen K, Saegerman C. Croatian Medical Journal. 2010; 51:296-305
Abubakar M, Mansoor M, Arshad MJ. Bovine brucellosis: Old and new concepts with Pakistan perspective. Pakistan Veterinary Journal. 2012; 32(2):147-155
Bano Y, Lone SA. Brucellosis: An economically important infection. Journal of Medical Microbiology & Diagnosis. 2015; 4:208. DOI: 10.4172/2161-0703.1000208
Pappas G. The changing Brucellaecology: Novel reservoirs, new threats. International Journal of Antimicrobial Agents. 2010. DOI: 10.1016/j.ijantimicag.2010.06.013
Gul ST, Khan A. Epidemiology and epizootology of brucellosis: A review. Pakistan Veterinary Journal. 2007; 27(3):145-151
McDermott J, Grace D, Zinsstag J. Economics of brucellosis impact and control in low-income countries. Revue scientifique et technique (International Office of Epizootics). 2013; 32:249-261
Falade S. Serological response of sheep to Brucellamelitensis rev. 1 Vaccine. Zoonoses and Public Health. 1983; 30(1-10):546-551
Ahmad R, Munir MA. Epidemiological investigation of brucellosis in Pakistan. Pakistan Veterinary Journal. 1995; 15:169-172
Ahmad T, Iahtasham K, Saddaf R, Saeed HK, Raheela A. Prevalence of bovine brucellosis in Islamabad and Rawalpindi districts of Pakistan. Pakistan Journal of Zoology. 2016; 49(3):761-1149. DOI: 10.17582/journal.pjz/2017.49.3.sc5
Alavi SM, Alavi L. Treatment of brucellosis: A systematic review of studies in recent twenty years. Caspian Journal of Internal Medicine. 2013; 4(2):636-641
Rajala EL, Cecilia G, Isabel L, Nosirjon S, Sofia B, Ulf M. Prevalence and risk factors for Brucellaseropositivity among sheep and goats in a peri-urban region of Tajikistan. 2016; 48(3):553-558
Alavi SM, Rajabzadeh AR. Comparison of two chemotherapy regimen: Doxycycline-rifampicin and doxycycline cotrimoxazol in the brucellosis patients AHVAZ, IRAN, 2004-2006. Pakistan Journal of Medical Sciences. 2007 (Part-II); 23(6):889-892