Type of episiotomy.
\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
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When parents are engaged in students’ academic experiences they are more likely to know what is being taught in students’ classes and can to find ways to support their learning at home. As the significance of parent involvement becomes more evident school leaders, teachers, and policy makers are exploring ways to expand parent involvement. There is a motivation to move beyond traditional approaches such as parent-teacher conferences to more dynamic, engaging approaches where parents’ knowledge is valued and leveraged to create culturally responsive education experiences. Even though the structure of formal K-12 schools creates more opportunities for parents to participate in young elementary students’ education experiences, middle school students still show great benefit when their parents participate in school-based events and academic experiences [2].
If parents can engage in academic tasks with their students, it extends students’ instruction experiences. Students have more opportunities to discuss content, relate it to real world contexts and make meaningful connections to their lived experiences. These experiences could improve students’ science, technology, engineering, and math (STEM) knowledge and lead to increased learning outcomes.
This chapter summarizes some of the work being done on the Fostering Equitable Science through Parental Involvement and Technology (ESPRIT) Project that focuses on the ways that parents participate in activities designed to increase their involvement in middle school students’ science education experiences. In the ESPRIT project work, ethnic and racial minority and immigrant parents are invited to create video responses to questions and activities assigned by their middle school students’ science teachers.
ESPRIT leverages a technology-enhanced social learning environment (SLE) called Flipgrid™ (flipgrid.com) to engage science teachers and student-parent pairs in discussions and activities designed to create connected learning experiences [3] that prompt middle school students to connect their personal interests and cultural knowledge with their academic science learning experiences. The Flipgrid social learning environment is available via an app that works on laptops, tablets, and smart phones. In a typical sequence of events, teachers create a video or text based question or assign a brief activity within the SLE and share the question via a secure link sent to students and parents. Then parents and students create a video-based response between 90 seconds and 5 minutes long. Teachers can show the video responses during class, respond to them individually, or ask students to engage in an online discussion by responding to each other’s videos. This project is well-situated to examine the rich affordances of computer supported collaborative learning experiences as we focus on how teachers, students, and parents form a dynamic knowledge building community via interactions with the SLE activities [4].
A major facet of the ESPRIT project research is to understand the ways in which participating in the SLE activities increases parent involvement. This chapter presents a new model intended to expand the notion parent involvement to focus on behaviors and activities that shift and adjust as teachers, students, and parents participate in a range of constructive, collaborative activities. The chapter also highlights roles that parents take on as they participate in an online social learning environment. These ideas are relevant for researchers, teachers, and curriculum designers interested in new ways to support parent involvement and incorporate technology into science education experiences.
Parent involvement is broadly defined as the behaviors that parents engage in with their children at home and the activities they participate in in school contexts. In their conceptualization of parent involvement, the authors in [5] describe parent involvement as having three dimensions related to behavioral, affective, and cognitive behaviors. They further specify that in order for children to experience the positive benefits of parent involvement, they must actively process information related to the involvement behaviors and incorporate it into their attitudes, motivations, and school-based schemas.
Recent research aimed at understanding home-school relationships asks that we reconceptualize parent involvement as parent engagement that is “a two-way interaction process between school and home, referring to a mutual exchange of values and knowledge. It places emphasis on reciprocity, empowerment, empathy, change and opportunities for both parents and the school” [6], p. 11.
Other perspectives of parent involvement discuss the distinction between parent involvement and parent engagement as a continuum of roles [7]. At one end of the continuum, parents participate in traditional parent involvement activities. They are primarily recipients of information from teachers and participants in school-directed activities. The other end of the continuum represents more active parent engagement where parents have agency and participate in activities that directly support student learning. This continuum framing aligns with the call for schools to view families as partners who can play important roles that support students’ academic success [8].
Many types of parent involvement have been shown to support students’ educational experiences and increase student learning outcomes [9]. To build on this knowledge, teachers, curriculum designers and researchers can leverage technology to take advantage of the fact that parents are driven to be engaged in meaningful ways and are willing to take on significant roles in their students’ education experiences. As we consider how technology can support student learning, we can also focus on how it can enhance parent involvement.
The ESPRIT project embodies this approach to broadening the impact of technology in education. In the social learning environment, teachers ask open-ended questions that allow parents and students to determine how they want to respond. Parents are asked to participate in activities that invite them to make cognitive, socio-emotional, or cultural contributions to the tasks. Parents also have more agency to structure the activities they engage in with their children. For example, as they record a video response, parents might share an experience from their lives that relates to an academic lesson their child is learning at school. In discussions with their child, they could share their ideas about how a particular content area relates to real world issues, or they could explain a scientific phenomenon and the factors that influence it. Prior to recording their video responses, parents and students are likely to have offline discussions to decide what they are going to say. After they post their responses, they may continue to discuss the content and ideas included in their response. The full cycle of parents and students creating responses that teachers can use during instruction creates the mutual exchange of knowledge that supports the type of parent involvement being called for in current educational research.
Multiple studies indicate that parents from diverse cultural and ethnic backgrounds recognize the importance of education and are keen to participate in their students’ education experiences. However, there are barriers to participation that parents from minority, immigrant, and low-socioeconomic status groups are likely to experience [10]. For instance, parents from minority groups have expressed challenges related to transportation and scheduling issues. Immigrant parents who do not speak English may experience additional obstacles that prevent them from participating in traditional parent involvement activities [11]. Language and communication are among the most frequently cited variables that influence the ways that immigrant families participate in school events [12].
In an interview based study of Latino immigrant parents, participants summarized the communication and scheduling frustrations they experience when trying to participate in activities like parent-teacher conferences and open house night. Time was also mentioned as a barrier because some parents work evenings and cannot attend after school events. Communication was reported as a barrier because translators were not always available. Parents also expressed confusion about knowing the ways to best support their children’s learning. A general frustration with not knowing what was expected of them created a culture of dissatisfaction and confusion [13].
In addition to these reported barriers, narrow views of parent involvement are likely to overlook ways that parents from diverse cultural and ethnic backgrounds are involved in students’ education experiences [6].
Parents have access to multiple types of technology platforms (i.e., laptop computers, mobile phones, tablets) and recognize that these tools can be used to broaden the ways that they are involved in their children’s education [14].
In the ESPRIT Project, parents and students create video-based responses in their homes or other locations in their community, and they are able to do it in a fairly short timeframe that fits their schedules. In several cases, parents speak in Spanish, Somali, Hmong, or Karen. Members of our research team translate those responses, or the teachers ask students to translate as they show the response during class. By using the SLE environment, teachers emphasize and value the diversity of languages spoken in their students’ families.
When teachers design prompts and activities for parents and students to complete together, parents are developing an awareness of the content being covered in their child’s science lessons. In addition, parents are included in the school community when teachers show parents’ recorded responses in their classrooms. Because teachers are able to use the SLE across multiple curriculum units, they create several SLE assignments throughout the school year and establish an expectation that parents and students should work together to discuss content being covered in their science lessons.
For example, in her lesson about scientific practices, a fifth grade teacher created a prompt asking parents to explain what scientists do. Parents recorded videos in the social learning environment. Their responses included ideas about discovering cures for illnesses, conducting experiments, and solving problems. During her lesson, the teacher quickly transcribed the responses on a post-it note while she played the parent video responses for the class. Then, she asked the class which scientific practice they thought the parent was talking about according to a chart in the classroom. Once the students agreed on the practice, the student whose parent was speaking in the video response took the post-it note and placed it in the section of the chart with the practice identified in the discussion.
In addition to the home-school connections that are being created, it is also important to note that because parents and students can view responses from other families, they are getting to know more about the families in the school community. Overall, using the social learning environment addresses some of the typical barriers immigrant and minority parents face and provide meaningful opportunities for all parents. These types of parent involvement are changing the ways that parents are engaged in their children’s learning and enriching the ways that teachers are providing instruction.
Currently, the ways that parents are invited to participate in their children’s learning are largely routine; whether they are asked to help them study for tests, complete daily homework, or assist with large project-based assignments. Still, these activities have been shown to have positive impacts on academic outcomes and are customarily offered as involvement opportunities in most K-12 schools in the US. The argument presented in this chapter is not that these types of involvement are not important and impactful. Instead, I am suggesting that there are ways to expand our thinking about parent involvement so that parents and students are continually exploring ways to connect academic experiences to meaningful, real-world contexts and students’ lived experiences.
Figure 1 presents a new model of productive parent involvement that illustrates the ways that parents participate in students’ academic experiences. It builds on ideas related to adaptive expertise [15], and is meant to provide a framework for thinking about how parents experience parent involvement activities.
New model of productive parent involvement.
When parents are new to the school environment or are engaging in unfamiliar activities they are involved novices. They do not have enough experience engaging in the tasks to feel that they can be innovative or creative nor do they have enough practice so that participating in the activities feels familiar. If parents are unable to develop a comfort level and knowledge base so that the parent involvement activities become familiar, they may view it as a generally frustrating endeavor. They are also unlikely to advance from being novices.
In cases of routine involvement, parents become familiar with particular opportunities for involvement and are able to master particular ways of being involved. They may participate in a variety of activities ranging from attending parent teacher conferences and other school events to assisting their children with homework. These behaviors are largely unidirectional. School administrators and teachers create the experiences and have a fairly scripted role for parents to play. Parents and students may become bored, passive, and unmotivated in these instances of routine parent involvement.
In this model, productive parent involvement occurs when parents are invited to participate in a broad range of activities that support their child’s education. They have the scaffolded support needed to try new activities and become familiar with them. Over time, they can further enhance their involvement by personalizing activities and connecting them students’ everyday lived experiences. The model is intended to illustrate the idea that productive parent involvement requires multiple experiences that allow parents to become familiar with the activities. It also underscores the need for to challenge and inspire parents to engage in innovative thinking about their students’ education.
Figure 2 presents the model with technology featured as a mechanism for supporting parent involvement activities and for promoting productive parent involvement. In this version of the model, novice involvement is that in which parents have little to no experience or knowledge of a new technology being utilized. As an example, imagine that schools and/or teachers are attempting to try new technologies to support parent involvement. However, parents are not receiving the proper guidance or support to experience the value of the technology. Parents may try the new tools, become frustrated, and then ultimately decide not use them. At the school level, this might include utilizing a new parent portal designed to provide information about school events and grades. At the classroom level, teachers may ask parents to help their students use specific apps to complete homework assignments. When parents are new to the technology, they do not feel comfortable enough to use it efficiently nor do they have enough experience with it to support their students’ learning.
Technology and productive parent involvement.
Frustrated involvement occurs when parents are asked to learn to use multiple technologies with little support. They might also be asked to use too many technologies (i.e., apps for homework, texting and email for communication, and portals for information). As more school districts adopt one-to-one device programs, parents are likely to see a wide range of technologies that their children are being asked to use. Without proper guidance and support, they may become frustrated and decide that they are unable to be involved as much as they would like. Parents are also likely to become frustrated when they are asked to utilize technology to increase home-school connections that are primarily unidirectional [16].
When parents use a particular technology one way without making adjustments based on the academic content, students’ understanding, cultural knowledge, or personal interests and routine involvement becomes the norm. While this type of involvement may be fine in the short term [17], it does not hold much promise for sustained engagement.
By using a technology-enhanced social learning environment, we avoid frustrated and routine parent involvement because parents are invited to participate in students’ learning in a variety of activities. They are asked to engage in familiar activities like discussing everyday ideas and explaining scientific phenomena. They are asked to complete demonstrations and experiments at home with their students and they are invited to share their cultural knowledge and expertise. The social learning environment remains the same, but the activities that parents participate in with their students is ever-changing. Over time, parents are able to become active and engaged participants in students’ academic experiences. They are more likely to understand what students are learning in their classes and know how to support them at home. They are empowered to engage in productive parent involvement where share knowledge, learn new ideas, and try new activities with their children.
In the ESPRIT Project, parent involvement occurs through discourse within a technology-enhanced social learning environment. By assigning prompts that students and parents complete together, teachers are inviting parents to take on a variety of roles that enhance students’ learning experiences. In our work, one way that we explain the various participation dynamics is to characterize parents’ participation by describing the roles they play. The roles could vary based on the structure and content of the prompt. They could also vary based on the parents’ personality and experience with the project activities. We have observed four main roles that parents take on as they generate video responses with their children: [1] passive participant, [2] scientific knowledge resource, [3] cultural knowledge resource, and [4] co-learner.
Many parents begin as
Another SLE prompt asks, “What is the oldest thing you own? Do you know how old it is and where it came from?” In one of the responses, we can see and hear the student talking while her mother is off camera giving her details about the items she is describing and directing her to turn the camera around to show some of the items. Even when they are responding directly to the prompts, several parents’ initial responses are voice only responses. They do not show their faces, but they provide information related to the prompt.
After observing their children creating one or two prompt responses, parents are likely to transition from being passive participants to engaging in more active roles. Once parents are actively participating it is possible to further characterize their roles by the type of information they share.
In some cases, parents serve as a
Parents take on the role of a
When parents are involved in their students’ learning as a resource the experience is largely passive for the students. However, students are benefitting from revisiting scientific information covered in their classes or hearing new scientific ideas. When parents share cultural knowledge, students see the value of their funds of knowledge [18] and make important home-school connections.
A fourth role we have observed is that of
New understandings of parent involvement are necessary as more efforts are made to use technology to connect students’ home and school environments. The work in this chapter expands parent involvement research by focusing on how parents are involved in academic tasks with their students. It also recognizes the power of technology to create new pathways for parent involvement and contributes to a growing body of work focusing on parent roles and outcomes [19].
The flexibility and accessibility of mobile technologies and apps allow parents who may not be typically involved in education to engage in a range of activities that can enhance their children’s educational experiences. Technology can expand parent involvement from unidirectional, school-based, experiences to community-building experiences that encourage parents to discuss academic ideas with their children, their family members, and other families in their school community.
In the ESPRIT project, we have observed how technology can help parents from diverse backgrounds to engage in academic activities with their students and have an impact on their students’ classroom experiences. Parents share their knowledge in their own voice and in their first language. In some instances, the teacher shows the video response in class and the student translates. This sends a powerful message that the students’ funds of knowledge are valued in their classrooms. Even if teachers do not show all of the video responses in class, the act of being asked to engage in the SLE tasks, has impressive impacts. Students see that their parents have valuable knowledge to share, and parents feel validated as key advocates in their children’s academic experiences.
The roles that parents play in the SLE activities illustrate that technology enhanced interventions can increase and sustain parent involvement so that parents are able to engage in productive parent involvement. The SLE is flexible enough that teachers can invite parents to participate in a multiple roles across a wide range of content areas. Parents and students are able to participate in academic activities that are culturally rich and personally meaningful.
There is evidence that when teachers enact technology-enhanced systems, parents are likely to use the system as well. Additionally, the more frequently teachers incorporate these systems into their classroom practices, the more they become a normative aspect of parent involvement [19]. Once this happens, a critical feedback loop can be created so that parents have a better understanding about what is happening in classrooms and teachers develop an awareness of the wealth of knowledge parents have that can enhance their instruction [20].
Parent involvement requires innovative thinking about ways to provide opportunities for parents to participate in their children’s education experiences. This type of thinking is especially important in order to include parents from underrepresented groups who are more likely to experience inequities and disadvantages that prevent them from being as engaged as parents from majority populations. Technology-enhanced parent engagement activities like those discussed in this chapter can elicit academic discourse that is culturally responsive and personally relevant.
The ESPRIT project is funded by a grant from the National Science Foundation (#1657088). Any opinions, findings, and conclusions expressed in the chapter are those of the author and do not necessarily reflect the views of the National Science Foundation. I would like to acknowledge the hard work and creative ideas from all of the ESPRIT research team members: Tayler Loiselle, Elena Gullickson, Isabel Lopez, Abdirashid Abdi, Corissa Wurth, Samuel Bullard, Madeline Quickstad, Daria Zharova, and Lucas Simpson. This work would not be possible without all of you.
Keisha Varma has NO affiliations with or involvement in any organization or entity with any financial or non-financial interest in the subject matter or materials discussed in this chapter.
Thank you to all of the teachers, students, and parents who have participated in the ESPRIT project activities.
Episiotomy is a surgical cut in the tissue between the vagina and the anus (called the perineum) made just before delivery. It is one of the most commonly practiced obstetric procedures done to enlarge the diameter of the vulval outlet to facilitate the passage for the fetal head and prevent an uncontrolled tear of the perineal tissues in the second stage of labor [1, 2, 3]. The procedure was introduced into obstetric practice without any sound scientific evidence corroborating any possible benefits [4]. It was promoted in the twentieth century by renowned interventionists, obstetricians such as Gabe and De Lee [5]. Their perception was that the female body was essentially defective and dependent on medical interventions to enable childbirth [5]. In 1970s, there was disagreement in the practice especially because of pressure from the women’s movements demanding changes in the obstetric model [4].
In 1983, Thacker and Banta gave a full account of the lack of scientific data supporting the use of episiotomy and the potential danger associated with the procedure [3]. Historical indications such as a prolonged second stage, macrosomia, non-reassuring fetal heart rate, instrumental delivery, occiput posterior position, and shoulder dystocia have been questioned [6].
Routine episiotomy is now considered to be obstetrics violence when a woman is automatically transformed into a patient and when routine medical procedures are carried out without giving the woman the right to make her own decisions concerning her own body [7].
The most commonly practiced and accepted type of episiotomy is the mediolateral, owing to its protective roles in preventing obstetric anal sphincter injury (OASI) [8]. Median/midline episiotomy, although has a bigger risk of causing OASI, is praised for causing less pain/bleeding, ease in repair, and healing more easily [9]. A clear illustration and description of the type of episiotomy can be seen in Figure 1 and Table 1. Other reported episiotomy types in literature are lateral episiotomy, which was condemned, and also a J-shaped episiotomy incision that is not commonly practiced.
Illustration of episiotomy types.
Type of episiotomy | |
---|---|
Definition | Way of execution |
Median | The incision starts at the posterior fourchette and runs along the midline through the center of the perineal body. The incision should run for approximately half of the length of the perineum (2–3 cm) without affecting the anal muscle |
Mediolateral | An incision is performed downward and outward from the midpoint of the fourchette, either to the right or left toward the ischial tuberosity with 3–4 cm length, beginning in the midline and directed laterally, and downward away from the rectum. It affects the skin, subcutaneous tissue, bulbospongiosus muscle, superficial transverse perineal muscle, and the levator |
Lateral | The incision starts from about 1 cm (0.4 in) away from the center of the fourchette and extends laterally. Possible complications comprise injury to the Bartholin’s duct, which is why lateral incisions are deemed inadvisable by most specialists and rarely mentioned in the obstetric literature |
J-shaped episiotomy | It entails a midline incision, curved laterally away from the anus. Curved scissors are used starting in the midline of the vagina until the incision is 2·5° cm from the anus, then directing the incision toward the ischial tuberosity away from the anal sphincter |
Radical lateral (Schuchardt incision) | Generally considered a non-obstetrical incision, it is a fully extended episiotomy, deep into one vaginal sulcus and is curved downward and laterally partway around the rectum. It may be carried out at the beginning of radical vaginal hysterectomy or trachelectomy to allow easy access to the parametrium, to enable extraction of a neglected vaginal pessary, or quite rarely, to facilitate childbirth if complications arise (fetal macrosomia, difficult breech, or shoulder dystocia) |
Episiotomy incision is generally repaired after delivery of placenta to achieve hemostasis and approximate lacerated tissues. The aseptic procedure is carried out in a well-lit room with adequate exposure and appropriate instruments and anesthesia. Since most if not all repairs are done in laboring wards, adequate local or regional analgesia is used. Extension to a third- or fourth-degree perineal tear may necessitate examination under anesthesia and requires regional or general anesthesia that is done in an operating theater.
A suture is placed approximately a centimeter proximal to the apex of the incision within the vagina and secured with a knot, vaginal mucosa, and sub-mucosa are sutured up to the hymeneal ring, perineal muscles are then approximated followed by the closure of perineal skin using a continuous subcutaneous suturing technique [11]. Continuous stitching technique is preferred to interrupted as it is associated with less pain, easily performed by the inexperienced operator, and economical [12].
Episiotomy is practiced in varied ways with differing prevalence ranging from as low as less than 1/3 to as high as 86% [13] depending on whether it is used routinely or in a restricted way.
World Health Organization (WHO) Guideline Developing Groups emphasized the need for health systems to adopt a policy of restrictive rate of not more than 10% rather than routine use of episiotomy to reduce its potential complications and the use of additional resources for its treatment [14] as restrictive episiotomy has shown benefits [15]. Restrictive other than routine episiotomy protocol has been supported by FIGO [16], a mediolateral episiotomy type is the one recommended, and this should be performed under adequate analgesia, whether anesthesia is already in place for labor, such as epidural, or by administering a local infiltration [16].
Despite the controversy regarding the validity of episiotomy’s routine use in obstetrics and the fact that liberal use of the procedure has been discouraged, this is still one of the most commonly performed obstetric procedures worldwide [17, 18]. Although this restrictive episiotomy practice has shown many benefits, especially regarding the reduction of injuries to the posterior perineum, the strictest definition of restrictive use was to avoid episiotomy unless indicated for fetal well-being. Other definitions of restrictive episiotomy are to “avoid the procedure,” use only when “medically necessary,” or not perform an episiotomy to avoid a laceration [19]. The balance between risk and benefit for episiotomy is therefore not entirely straightforward. An episiotomy may be unavoidable if the baby needs to be delivered quickly.
The lack of evidence supporting episiotomy benefits has caused a significant decline in the practice in most countries. In France, a decline from 15.5% in 2013 to 9.3% in 2017 has been realized [20], and for operative vaginal births, there had been a varied decrease in episiotomy rates from as low as 25% to as high as 75% in some geographical location in France [21].
Historical indications for episiotomy included: abnormal progress of labor, non-reassuring fetal status, prematurity, assisted vaginal delivery, shoulder dystocia. It was also believed to hasten the second stage of labor, decrease pelvic floor disorder and sexual dysfunction, reduce urinary and fecal incontinence [15]. Several guidelines recommend the use of mediolateral episiotomy for the prevention of obstetric anal sphincter injuries (OASI) [8]. Episiotomy plays the main role during assisted vaginal birth as this is related to the increased incidence of OASI. The procedure can be indicated when there is a high likelihood of third-degree or fourth-degree perineal tear, soft tissue dystocia, a requirement to accelerate delivery of a compromised fetus, and need to facilitate operative vaginal delivery or a history of female genital mutilation [22].
Varied risk and protective factors are influencing the practice of episiotomy in obstetrics. The risk factors include primiparity [23, 24], absence of prior vaginal birth, assisted vaginal delivery are among the predictive factors influencing episiotomy practice. In some settings, episiotomy operations were being performed to allow midwifery and medical students the opportunity to learn and practice the procedure [24]. Being an adolescent and having other medical conditions while pregnant is associated with the procedure [25].
Factors that are protective against episiotomy include perineal massage. This procedure can be done especially in the second stage of labor [26, 27, 28]. The procedure is an effective approach to increasing the chance of delivery with intact perineum especially for women with a first vaginal birth [29]. In other literature, massage can be started as early as 34 weeks of gestation, and it is done with oil for 5–10 min every day to increase flexibility and elasticity [30]. In addition to massage, perineal support and warm compresses during the second stage are protective for episiotomy and anal sphincter injury [30].
Another important innovative tool to reduce the risk of episiotomy is an Epi-No device, developed in early 2000, to facilitate a natural birth and reduce the risk of perineal injury including needs for episiotomy. The Epi-No device is promising, with potentially positive effects on a natural birth without major complications [31].
OASI are injuries that involve the anal sphincter. It is dreaded complication after a vaginal delivery that has significant maternal morbidity such as perineal pain, dyspareunia, flatulence, and anal incontinence [33].
OASI either involves third or fourth-degree perineal tears. A third-degree perineal tear is defined as a partial or complete disruption of the anal sphincter muscles, a fourth-degree involves the rectal mucosa [34] as seen in Table 2 and Figure 2.
Third-degree tear | Injury to the perineum involving the anal sphincter complex |
---|---|
3A | Less than 50% of EAS thickness torn |
3B | More than 50% of EAS thickness torn |
3C | Both EAS and IAS torn |
Fourth-degree tear | Injury to perineum involving the anal sphincter complex (both EAS and IAS) and anal epithelium |
Buttonhole tear | External anal sphincter intact but anal or rectal mucosa with or without internal anal sphincter tear |
Description of OASI.
Adopted from [35].
Key: IAS, internal anal sphincter; EAS, external anal sphincter.
OASI; (a) third-degree perineal tear, (b) fourth-degree perineal tear. Adopted from [
The risk of getting OASI can be done by relieving pressure on the central posterior perineum by an episiotomy and/or controlled delivery of the head. An episiotomy aimed at 60° from the midline has been seen to be protective for OASI [36]; hence, the introduction of episiotomy scissors specially designed to achieve a cutting angle of 60°, EPISCISSORS-60® [37]. Vacuum-assisted delivery and bigger babies were seen to be an important independent factor in one cohort study [38].
A repair can be done primarily if OASI is diagnosed following vaginal delivery, and this represents the mainstay of treatment. A delay of up to 12 h is allowable if resources for repair are not available. A secondary repair can be done later when tissue edema has subsided for cases diagnosed later or if injuries have been unrepaired for more than 12 h, and this is referred to as secondary repair [39].
The aim of sphincter repair (either primary or secondary) is to restore a functioning anal canal by reconstruction of a muscular cylinder that is at least 2 cm thick and 3 cm long [39].
Meticulous hemostasis and anatomic approximation with a multilayer closure of all disrupted tissue layers are the key principles for preventing complications and restoring fecal continence and two recognized methods for the repair of OASI: end-to-end (approximation) and overlap repair [39] are important depending on the extent of the injuries as illustrated in Figure 3.
Episiotomy repair technique. Adopted from [
An overlap is more superior to an end-to-end method in terms of reduction in perineal pain, dyspareunia, flatus incontinence, and fecal incontinence [39, 40].
Although the repair techniques have been well documented, the confidence in detecting OASI and competence in the repair of OASI does not correlate with knowledge of anatomy and risk factors of OASI in a survey among obstetricians [41].
The suitability of routine use of episiotomy has been questioned by specialists and scientific societies, and several professional medical associations and patient and women’s rights advocates have been associating it with obstetric violence [9]. Episiotomy has been associated with the risk of repeat episiotomy in the subsequent birth due to tighter perineum and weaker scar [42]. Post episiotomy pain is common after delivery, and this may end up in pain at first intercourse especially if it occurs in the first 3 months after delivery [43]. The risk is higher if intercourse occurs within the first 6 weeks after delivery and in some cases, women present with gaping episiotomy wounds following intercourse [44]. The incision substantially increases maternal blood loss, the average depth of posterior perineal injury, risk of anal sphincter damage, improper wound healing, increased amount of pain in the first several postpartum days, and infection [45]. Episiotomy at the first vaginal birth significantly and independently increases the risk of repeated episiotomy and spontaneous tears in subsequent delivery [42, 46].
Episiotomy-related morbidity can be measured using the Redness, Ecchymosis, Edema, Discharge, and Apposition scale (REEDA scale) [47]. Higher REEDA scores denote poor healing process or severe trauma to the perineal tissue as shown in one of our studies in Mulago Hospital in Uganda [48]. The rate of the gaping wound is particularly higher among those done episiotomy compared with spontaneous perineal tear [48], and this can be attributed to the fact that spontaneous perineal tear occurs normally along the natural tissue planes, and it’s easier to repair compared with episiotomy. A similar study in Mulago relates episiotomy to increased risk of infection and the need for secondary re-suturing [49].
Episiotomy-related pain has been shown to persist for more than 14 days after delivery [48] supporting claims that cutting across tissue planes is associated with more pain compared with spontaneous tear that normally follows the natural tissue planes as reported by [3, 50, 51] and that episiotomy is a painful policy [2]. A meta-analysis done by [52] found out that episiotomy is associated with increased incidence and severity of postpartum perineal pain.
An episiotomy is, therefore, a traumatic procedure that should be practiced restrictively. World Health Organization (WHO) Guideline Developing Groups and FIGO emphasized the need for health systems to adopt a policy of restrictive rate of not more than 10%, and mediolateral episiotomy type is the one recommended, and this should be performed under adequate analgesia, whether anesthesia is already in place for labor, such as epidural, or by administering a local infiltration.
The authors declare no conflict of interest.
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Thin films are considered as backbone for advanced applications in the various fields such as optical devices, environmental applications, telecommunications devices, energy storage devices, and so on . The crucial issue for all applications of thin films depends on their morphology and the stability. The morphology of the thin films strongly hinges on deposition techniques. Thin films can be deposited by the physical and chemical routes. In this chapter, we discuss some advance techniques and principles of thin-film depositions. The vacuum thermal evaporation technique, electron beam evaporation, pulsed-layer deposition, direct current/radio frequency magnetron sputtering, and chemical route deposition systems will be discussed in detail.",book:{id:"5541",slug:"modern-technologies-for-creating-the-thin-film-systems-and-coatings",title:"Modern Technologies for Creating the Thin-film Systems and Coatings",fullTitle:"Modern Technologies for Creating the Thin-film Systems and Coatings"},signatures:"Asim Jilani, Mohamed Shaaban Abdel-wahab and Ahmed Hosny\nHammad",authors:[{id:"192377",title:"Dr.",name:"Asim",middleName:null,surname:"Jilani",slug:"asim-jilani",fullName:"Asim Jilani"},{id:"192972",title:"Dr.",name:"M.Sh",middleName:null,surname:"Abdel-Wahab",slug:"m.sh-abdel-wahab",fullName:"M.Sh Abdel-Wahab"},{id:"192973",title:"Dr.",name:"Ahmed",middleName:"H",surname:"Hammad",slug:"ahmed-hammad",fullName:"Ahmed Hammad"}]},{id:"17722",doi:"10.5772/23174",title:"Study of SiO2/Si Interface by Surface Techniques",slug:"study-of-sio2-si-interface-by-surface-techniques",totalDownloads:14161,totalCrossrefCites:13,totalDimensionsCites:35,abstract:null,book:{id:"332",slug:"crystalline-silicon-properties-and-uses",title:"Crystalline Silicon",fullTitle:"Crystalline Silicon - Properties and Uses"},signatures:"Rodica Ghita, Constantin Logofatu, Catalin-Constantin Negrila, Florica Ungureanu, Costel Cotirlan, Adrian-Stefan Manea, Mihail-Florin Lazarescu and Corneliu Ghica",authors:[{id:"50919",title:"Dr.",name:"Rodica V.",middleName:null,surname:"Ghita",slug:"rodica-v.-ghita",fullName:"Rodica V. 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The principles underlying RF‐magnetron sputtering used to prepare calcium phosphate‐based, mainly hydroxyapatite coatings, are discussed in this chapter. The fundamental characteristic of the RF‐magnetron sputtering is an energy input into the growing film. In order to tailor the film properties, one has to adjust the energy input into the substrate depending on the desired film properties. The effect of different deposition control parameters, such as deposition time, substrate temperature, and substrate biasing on the hydroxyapatite (HA) film properties is discussed.",book:{id:"5541",slug:"modern-technologies-for-creating-the-thin-film-systems-and-coatings",title:"Modern Technologies for Creating the Thin-film Systems and Coatings",fullTitle:"Modern Technologies for Creating the Thin-film Systems and Coatings"},signatures:"Roman Surmenev, Alina Vladescu, Maria Surmeneva, Anna Ivanova,\nMariana Braic, Irina Grubova and Cosmin Mihai Cotrut",authors:[{id:"193921",title:"Dr.",name:"Alina",middleName:null,surname:"Vladescu",slug:"alina-vladescu",fullName:"Alina Vladescu"},{id:"193922",title:"Prof.",name:"Roman",middleName:null,surname:"Surmenev",slug:"roman-surmenev",fullName:"Roman Surmenev"},{id:"193923",title:"Dr.",name:"Maria",middleName:null,surname:"Surmeneva",slug:"maria-surmeneva",fullName:"Maria Surmeneva"},{id:"193948",title:"Dr.",name:"Mariana",middleName:null,surname:"Braic",slug:"mariana-braic",fullName:"Mariana Braic"},{id:"194047",title:"Ms.",name:"Anna",middleName:null,surname:"Ivanova",slug:"anna-ivanova",fullName:"Anna Ivanova"},{id:"194048",title:"BSc.",name:"Irina",middleName:null,surname:"Grubova",slug:"irina-grubova",fullName:"Irina Grubova"},{id:"196398",title:"Prof.",name:"Cosmin Mihai",middleName:null,surname:"Cotrut",slug:"cosmin-mihai-cotrut",fullName:"Cosmin Mihai Cotrut"}]},{id:"21157",doi:"10.5772/24330",title:"Compilation on Synthesis, Characterization and Properties of Silicon and Boron Carbonitride Films",slug:"compilation-on-synthesis-characterization-and-properties-of-silicon-and-boron-carbonitride-films",totalDownloads:5219,totalCrossrefCites:6,totalDimensionsCites:19,abstract:null,book:{id:"326",slug:"silicon-carbide-materials-processing-and-applications-in-electronic-devices",title:"Silicon Carbide",fullTitle:"Silicon Carbide - Materials, Processing and Applications in Electronic Devices"},signatures:"P. Hoffmann, N. Fainer, M. Kosinova, O. Baake and W. Ensinger",authors:[{id:"56722",title:"Dr.",name:"Peter",middleName:null,surname:"Hoffmann",slug:"peter-hoffmann",fullName:"Peter Hoffmann"},{id:"56726",title:"Dr.",name:"Marina",middleName:null,surname:"Kosinova",slug:"marina-kosinova",fullName:"Marina Kosinova"},{id:"56727",title:"Prof.",name:"Wolfgang",middleName:null,surname:"Ensinger",slug:"wolfgang-ensinger",fullName:"Wolfgang Ensinger"}]}],mostDownloadedChaptersLast30Days:[{id:"52684",title:"Advance Deposition Techniques for Thin Film and Coating",slug:"advance-deposition-techniques-for-thin-film-and-coating",totalDownloads:7725,totalCrossrefCites:33,totalDimensionsCites:63,abstract:"Thin films have a great impact on the modern era of technology. Thin films are considered as backbone for advanced applications in the various fields such as optical devices, environmental applications, telecommunications devices, energy storage devices, and so on . The crucial issue for all applications of thin films depends on their morphology and the stability. The morphology of the thin films strongly hinges on deposition techniques. Thin films can be deposited by the physical and chemical routes. In this chapter, we discuss some advance techniques and principles of thin-film depositions. The vacuum thermal evaporation technique, electron beam evaporation, pulsed-layer deposition, direct current/radio frequency magnetron sputtering, and chemical route deposition systems will be discussed in detail.",book:{id:"5541",slug:"modern-technologies-for-creating-the-thin-film-systems-and-coatings",title:"Modern Technologies for Creating the Thin-film Systems and Coatings",fullTitle:"Modern Technologies for Creating the Thin-film Systems and Coatings"},signatures:"Asim Jilani, Mohamed Shaaban Abdel-wahab and Ahmed Hosny\nHammad",authors:[{id:"192377",title:"Dr.",name:"Asim",middleName:null,surname:"Jilani",slug:"asim-jilani",fullName:"Asim Jilani"},{id:"192972",title:"Dr.",name:"M.Sh",middleName:null,surname:"Abdel-Wahab",slug:"m.sh-abdel-wahab",fullName:"M.Sh Abdel-Wahab"},{id:"192973",title:"Dr.",name:"Ahmed",middleName:"H",surname:"Hammad",slug:"ahmed-hammad",fullName:"Ahmed Hammad"}]},{id:"68467",title:"Semiconductor Nanocomposites for Visible Light Photocatalysis of Water Pollutants",slug:"semiconductor-nanocomposites-for-visible-light-photocatalysis-of-water-pollutants",totalDownloads:1825,totalCrossrefCites:7,totalDimensionsCites:12,abstract:"Semiconductor photocatalysis gained reputation in the early 1970s when Fujishima and Honda revealed the potential of TiO2 to split water in to hydrogen and oxygen in a photoelectrochemical cell. Their work provided the base for the development of semiconductor photocatalysis for the environmental remediation and energy applications. Photoactivity of some semiconductors was found to be low due to larger band gap energy and higher electron-hole pair recombination rate. To avoid these problems, the development of visible light responsive photocatalytic materials by different approaches, such as metal and/or non-metal doping, co-doping, coupling of semiconductors, composites and heterojunctions materials synthesis has been widely investigated and explored in systematic manner. This chapter emphasizes on the different type of tailored photocatalyst materials having the enhanced visible light absorption properties, lower band gap energy and recombination rate of electron-hole pairs and production of reactive radical species. Visible light active semiconductors for the environmental remediation purposes, particularly for water treatment and disinfection are also discussed in detail. Studies on the photocatalytic degradation of emerging organic compounds like cyanotoxins, VOCs, phenols, pharmaceuticals, etc., by employing variety of modified semiconductors, are summarized, and a mechanistic aspects of the photocatalysis has been discussed.",book:{id:"7671",slug:"concepts-of-semiconductor-photocatalysis",title:"Concepts of Semiconductor Photocatalysis",fullTitle:"Concepts of Semiconductor Photocatalysis"},signatures:"Fatima Imtiaz, Jamshaid Rashid and Ming Xu",authors:[{id:"292882",title:"Dr.",name:"Jamshaid",middleName:null,surname:"Rashid",slug:"jamshaid-rashid",fullName:"Jamshaid Rashid"},{id:"302498",title:"Ms.",name:"Fatima",middleName:null,surname:"Imtiaz",slug:"fatima-imtiaz",fullName:"Fatima Imtiaz"},{id:"308434",title:"Prof.",name:"Ming",middleName:null,surname:"Xu",slug:"ming-xu",fullName:"Ming Xu"}]},{id:"17728",title:"Defect Related Luminescence in Silicon Dioxide Network: A Review",slug:"defect-related-luminescence-in-silicon-dioxide-network-a-review",totalDownloads:9508,totalCrossrefCites:46,totalDimensionsCites:99,abstract:null,book:{id:"332",slug:"crystalline-silicon-properties-and-uses",title:"Crystalline Silicon",fullTitle:"Crystalline Silicon - Properties and Uses"},signatures:"Roushdey Salh",authors:[{id:"48391",title:"Dr.",name:"Roushdey",middleName:null,surname:"Salh",slug:"roushdey-salh",fullName:"Roushdey Salh"}]},{id:"58469",title:"The Electrochemical Performance of Deposited Manganese Oxide-Based Film as Electrode Material for Electrochemical Capacitor Application",slug:"the-electrochemical-performance-of-deposited-manganese-oxide-based-film-as-electrode-material-for-el",totalDownloads:1754,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"The transition metal oxide has been recognized as one of the promising electrode materials for electrochemical capacitor application. Due to the participation of charge transfer reactions, the capacitance offered by transition metal oxide can be higher compared to double layer capacitance. The investigation on hydrous ruthenium oxide has revealed the surface redox reactions that contributed to the wide potential window shown on cyclic voltammetry curve. Although the performance of ruthenium oxide is impressive, its toxicity has limited itself from commercial application. Manganese oxide is a pseudocapacitive material behaves similar to ruthenium oxide. It consists of various oxidation states which allow the occurrence of redox reactions. It is also environmental friendly, low cost, and natural abundant. The charge storage of manganese oxide film takes into account of the redox reactions between Mn3+ and Mn4+ and can be accounted to two mechanisms. The first one involves the intercalation/deintercalation of electrolyte ions and/or protons upon reduction/oxidation processes. 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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