The essential circadian rhythm genes in mammals.
Human physiological activity and condition during illness are under the control of the circadian rhythm. Circadian rhythms handle a wide diversity of physiological and metabolic functions, and the interruption of these rhythms has been linked to obesity, sleep disorders, metabolic and psychological disorders, and cardiovascular events such as myocardial infarction (MI), stroke, and vascular death. Disruption of circadian rhythms increases the risk of developing myocardial infarction, indicating that circadian genes might play an essential role in determining disease susceptibility. It is well known that many cardiovascular processes show daily variations depending on the circadian rhythm (blood pressure, heart rate), and the gene expression of the cardiomyocyte circadian clock influences myocardial contractile function, metabolism, and other gene expressions. We present a review of the latest knowledge on the impact of circadian rhythm and circadian rhythm genes on myocardial infarction. Today, in a time of personalized medicine, it is essential to know each person’s circadian rhythm for its treatment and possible inclusion in the diagnostic procedures.
- circadian rhythm
- myocardial infarction
Everyday life is organized according to three different clocks: the solar clock which gives us light and temperature during the day, the social clock which determines the working day, and the biological clock which we notice during shift work or when we adjust to a reduced amount of daylight. In real life, the circadian clock is synchronized within 24 hours of the solar clock [1, 2].
It is known that almost all cardiovascular events occur in a circadian manner with a higher frequency in the morning after waking . In the peripheral clocks of the cardiovascular tissues or cells, there is daily expression of the clock-controlled genes (CCG) synchronized and regulated by central clock [4, 5]. Disturbances of circadian rhythm can lead to cardiovascular disease.
Today we are facing a global epidemic of cardiovascular disease. In 2015 cardiovascular disease was the cause of 17.7 million deaths worldwide or 31% of total mortality. Of these 7.4 million deaths were caused by ischemic heart disease and 6.7 million by cerebrovascular diseases, according to World Health Organization (WHO) .
2. Circadian rhythm
Circadian rhythm is controlled by a molecular clock located in almost every cell. A hierarchical system organizes molecular clocks—the master clock is located in the suprachiasmatic nucleus (SCN) in the hypothalamus [2, 7], while the peripheral clocks are located in each organ or cell. The central clock regulates physiological functions via the autonomic nervous system, humoral mediators, and other still unknown factors [7, 8]. In the maintenance and generation of circadian or biological rhythm in humans, a whole series of anatomical (suprachiasmatic nucleus), neurological (retinohypothalamic paths) and neuroendocrine (melatonin) systems are involved, indicating that the biology of the circadian rhythm of humans is similar to that of animals .
The master clock in the SCN consists of about 100,000 neurons in humans. It is the only molecular clock that receives light as an input signal from the retina. Internal clocks are synchronized with light depending on the time of day. SCN receives a direct light signal from the retina via the optic nerve from the photoreceptor called the intrinsically photoreceptive retinal ganglion cell (ipRGC), which expresses the circadian photopigment, melanopsin . The signal is further transmitted to peripheral clocks via the endocrine system [11, 12]. The central clock synchronizes each of the peripheral clocks in the body, and the primary circadian hormone is melatonin . The pineal gland secretes melatonin during the night. Melatonin plays an essential role in maintaining the circadian rhythm depending on the period of light or darkness. The main difference between the master and peripheral clocks is in their degree of intercellular interaction. Peripheral clocks are under the influence of the master clock from the SCN via hormones, chemical signals and other metabolites (such as food), as well as by changes in the body, such as body temperature [11, 12].
On the other hand, due to the high degree of neuron connection the master clock in the SCN is not under the influence of internal signals but only under the influence of light . Peripheral tissues integrate central clock signals with environmental factors (including sleepiness, physical activity, and feeding) and their autonomic rhythms which regulate the metabolism in a circadian manner . The rhythm of the peripheral clocks in humans is measured by direct measurement of physiological changes, or by determining the expression of the clock genes. Central and peripheral clocks together control the daily circadian rhythm of the metabolism .
Feeding time is one of the key triggers or external factors that sets the phases of the peripheral clocks . Complex feedback loops connect the circadian clock with metabolic pathways and integrate these systems independently of light . It is believed that the central clock regulates the metabolism by hormones (primarily cortisol and melatonin) and synaptic signaling (via the autonomic nervous system) . Feeding is a circadian event that serves not only as the output of the central clock, but also as an input signal for peripheral clocks because peripheral tissues communicate with the brain through ghrelin, leptin, glucose, and insulin. Circadian feeding contributes to the interworking of the clock and metabolism, which is crucial for metabolic homeostasis . The central clock rhythm is primarily related to light, whereas peripheral tissue rhythms derive from the input of signals from the central clock, external factors (light, physical activity, feeding, and sleepiness) and the availability of numerous metabolites . All these signals affect the molecular clock, creating a complex correlation between the circadian clock and physiological processes . SCN coordinates all cellular circadian clocks in the organs and tissues through its rhythmic outcomes, to adapt physiology to Earth’s rotation .
The two clock systems become desynchronized when their drivers or stimuli do not coincide because different stimuli affect the phases of the central and peripheral clocks. This mismatch disrupts the metabolism because the two clock systems coordinate interlinked metabolic pathways. Circadian rhythm mismatch increases the risk of developing metabolic diseases .
The central clock is primarily triggered by light, and its rhythm is often measured by determining the concentrations of melatonin, cortisol or body temperature . The expression of the clock genes is disrupted in pathological conditions. Such a change may result in different tissue response to external signals and accelerate tissue damage. The loss of synchronization can lead to various diseases, including an increased incidence of cardiovascular disease .
3. Molecular basis of circadian rhythm
The central clock genes are expressed in a circadian manner in the SCN, and light is one of the main initiators (so-called
ARNTL and CLOCK heterodimers bind to regulatory elements of the promoters and enhancers (E-box) of the
During the day a new cycle begins by the termination of the ARNTL-CLOCK heterodimer inhibition. Casein kinase 1 (CK1) controls the amount of phosphorylation or degradation of PER-CRY heterodimers and thereby determines the amount of PER-CRY heterodimer entering the nucleus and inhibiting the ARNTL-CLOCK complex. CK1 phosphorylates the proteins and thus regulates their activity .
The additional negative loop is REV-ERBα that binds to the REV-ERB/ROR response element (RRE) of the
Circadian clock genes have an essential role in many physiological processes. Thus, animal models demonstrate that the
|Rhythmically expressed. Physically associates with CLOCK. Promotes transcription of |
|Physically associates with and phosphorylates PER. Affects PER stability and nuclear localization.|
|Constitutively expressed. Physically associates with |
|Physically associates with and stabilizes PER. Negative regulator of Per and Cry transcription.|
|Physically associates with CRY. Positive regulator of |
|Associates with regulatory elements and negative regulator of the |
|Associates with regulatory elements and positive regulator of the |
|Circadian function not known. Physically associates with CRY. Negative regulator of |
4. Cardiovascular diseases
The WHO data for 2017 show that cardiovascular diseases were the cause of 19.9 million deaths worldwide, and about 80% of deaths from cardiovascular diseases were due to myocardial infarction and stroke . It is estimated that by 2030, 23.6 million people will die annually due to cardiovascular diseases .
Cardiovascular diseases are the primary cause of death in developed countries of the world, and in less developed parts of the world, this mortality is rising and overtaking mortality rates for infectious diseases .
There are variable and constant risk factors for cardiovascular disease. The variable risk factors are those that can be affected by therapy and lifestyle change, such as smoking, hyperlipoproteinemia, hypertension, and to some extent diabetes and homocysteinemia. The constant risk factors cannot be affected, namely age, genetic predisposition, gender, and menopause. The general risk factors which can be altered most are smoking, hypertension and hyperlipidemia, and obesity and diabetes whose prevalence has risen in the last few decades. However, some recent risk factors (fibrinogen, lipoprotein (a), homocysteine) should not be ignored. All of these contribute to total cardiovascular risk .
Cardiometabolic risk factors are determined by a cluster of metabolic and cardiovascular changes. Diabetes and obesity are also associated with reduced quality of life and increased economic burden on the person and society [46, 47]. Cardiovascular diseases and type 2 diabetes share common pathophysiological mechanisms of insulin resistance and risk factors for cardiovascular diseases, such as metabolic syndrome. Excessive weight plays a significant role because fatty tissue becomes an active endocrine organ that secretes low-level inflammation mediators, and these stimulate the development of metabolic syndrome and vascular diseases [32, 48, 49].
5. Myocardial infarction
Myocardial infarction is the leading cause of mortality in developed countries and developing countries. It can be caused and triggered by different pathophysiological processes. Myocardial infarction is an inflammatory disease due to the death of myocardial cells because of complete coronary circulation interruption, which is in most cases a consequence of thrombotic occlusion of the coronary artery at the site of the activated atherosclerotic plaque. An electrocardiogram (ECG) of the ST elevation is only an indirect indicator of the fact that ischemia affects all three layers of cardiac muscle (endocardium, myocardium, and epicardium) .
ST-elevation myocardial infarction (STEMI) is the most severe form of acute coronary syndrome. Myocardial infarction is accompanied by increased cellular oxidative stress in the pericardial cavity . The primary cause of infarction is platelet aggregation in the coronary artery. The platelet activity is the highest in the morning. Also, in the morning hours, mental and physical activity increase due to cortisol and catecholamine elevation, which increases cardiac output . The biochemical markers of myocardial damage are cardiac troponin T or troponin I in serum. These biochemical markers are more reliable than those previously used, such as measurement of creatine kinase (CK). The initial increase in troponin in peripheral blood in patients with infarction occurs over 3–4 hours with a permanent increase for up to 2 weeks after infarction. In order to confirm or exclude myocardial damage, troponin T serum levels are repeated in the first 6–12 hours after severe chest pain .
The classification of myocardial infarction in five types was introduced in 2007 and established the clinical criteria for its exact differentiation . Type 1 is related to a coronary plaque rupture, fissuring, or dissection with resulting intraluminal thrombosis. Type 2 myocardial infarction is secondary to myocardial ischemia resulting from increased oxygen demand or decreased supply. Type 3 myocardial infarction is linked to unexpected cardiac death when cardiac biomarkers are unavailable. Types 4 and 5 myocardial infarction are procedure related .
In the study of Saaby et al.,  it was shown that the most significant number of patients with myocardial infarction come under Type 1 (72%). In patients with Type 1 myocardial infarction, changes in the ECG are seen either as the elevation or depression of the ST segment; the troponin T level also increases in the blood and serves as a diagnostic marker. The troponin T level in the blood is higher in patients with Type 1 myocardial infarction than Type 2 .
For manifestation of infarction, apart from lifestyle, a genetic background of myocardial infarction is also essential. A positive family history of myocardial infarction is a major cardiovascular risk factor . Coronary artery disease and myocardial infarction have a genetic background in 50–60% of cases. Many genes are found in the genetic background of myocardial infarction. Whole genome association studies have revealed many variants of genes associated with increased risk for myocardial infarction . So far the most frequently explored genes with increased risk for myocardial infarction are involved in the metabolic pathways of lipid metabolism and development of type 2 diabetes. The relationship between the circadian rhythm genes and the onset of myocardial infarction will be discussed below.
6. Myocardial infarction and circadian rhythm
Many cardiovascular events and diseases have a circadian pattern of appearance. The normal circadian blood pressure shows the two highest values during the day, around 9 am and 7 pm, while there is a slight decrease around 3 pm. It is considered that circadian variations in the tone of coronary vessels and endothelial function play an essential role in the onset of myocardial infarction. As myocardial infarction is significant medical stress, it causes increased cortisol levels in plasma . In the acute phase of myocardial infarction, the phase of the circadian clock in the ischemic part of the heart differs from the non-ischemic part of the heart. The arrhythmia may occur because of the difference in the phase of the rhythm, or different expressions of the circadian clock genes. The loss of synchronization of the circadian rhythm between organs or tissues occurs more often than we would expect . Circadian regulation of physiological processes is regulated locally. Peripheral tissue clocks control tissue-specific expression .
Homeostatic changes, gene expression changes, and external triggers can cause a stressful environment and cause damage to the atherosclerotic plaque in the coronary arteries in the morning, when prothrombin is increased . Many intrinsic vasoactive and cardioactive substances, such as angiotensin II, melatonin, plasminogen activator inhibitor 1 (PAI-1), glucocorticoids, epinephrine, norepinephrine, and nitrogen oxide, show a specific circadian pattern. The fibrinolytic system, which regulates PAI-1, shows a circadian pattern of occurrence in both healthy patients and those with ischemic heart disease. The concentration and activity of PAI-1 depend on the circadian rhythm and are the highest in the morning . CLIF (Cycle-Like Factor) expression in endothelial cells creates heterodimers with CLOCK protein, and binds to the E-box of the
It is known that melatonin levels decrease during the night in coronary heart disease and infarction. Melatonin is an antioxidant that can inhibit the action of reactive oxygen radicals during heart ischemia. It also plays a vital role in regulating blood pressure, depending on the circadian rhythm. Animal studies have shown that animals with the pineal gland removed develop hypertension. Clinical examinations have shown that in patients with hypertension melatonin drugs taken daily before bedtime reduced blood pressure .
The appearance of myocardial infarction has two peaks during the day. The highest incidence of myocardial infarction is during the morning, and the second peak occurs late at night . The beta blockers prevent increased sympathetic activity, catecholamine concentration, heart rate, blood pressure and lack of oxygen in the heart, and these are the physiological reasons for the existence of two peaks of myocardial infarction [57, 61].
Ischemia occurs in the morning due to increased oxygen demand, whereas in the evening it is due to decreased coronary blood flow. The appearance of myocardial infarction depends on ethnic origin, and the British differ from Asians in the frequency of the infarction . In the Mediterranean, the highest incidence of myocardial infarction is between midday and midnight, while in the UK the highest incidence is between midnight and midday . Numerous factors might affect the later occurrence of infarction in the Mediterranean, such as the number of sunlight hours, inequality in the prevalence of risk factors for cardiovascular disease, and the habit of afternoon rest or ‘siesta’ . It has also been noted that the incidence of myocardial infarction is higher in the winter . The specific circadian pattern of infarction symptoms has been observed, and the correlation of the circadian rhythm gene with the infarction investigated. The role of the molecular circadian clock in myocardial activity was initially investigated on animal models. It has been observed that the clock gene mutations of the circadian rhythm affect the heart rate, myocardial contractility, energy metabolism, which altogether leads to ischemia [64, 65]. In contrast, variants of the
Different variations of circadian rhythm genes are associated with many risk factors for cardiovascular disease. Thus, CLOCK gene variations are associated with metabolic syndrome in humans, type 2 diabetes, and some with stroke [64, 66, 67, 68], while
6.1 Cardiomyocyte circadian clock
A peripheral clock is also found in cardiomyocytes, and the internal molecular mechanism of cardiomyocytes, such as the circadian clock, might contribute to cardiovascular disease . Similar to SCN, cardiomyocytes have a circadian expression of clock genes in response to serum shock or norepinephrine. Several genes are associated with intracellular metabolism or physiological activity that has a circadian expression in cardiomyocytes . After development, cardiomyocytes do not replicate, although they possess a meager and permanent rate of renewal. Cardiomyocytes renew cellular structure with their new proteins and membrane lipids every few weeks . The ischemic precondition is an adaptation of cardiomyocytes to hypoxia, and once the heart has suffered an ischemic insult, cardiomyocytes become more resistant to MI because of PER2 and hypoxia inducible factor (HIF)-1a . Circadian genes regulate a group of genes encoding for cardiac metabolic enzymes, and it is considered that a significant role of circadian genes in the heart is to synchronize cardiomyocyte metabolic activity with the availability of nutrients in the blood (i.e., feeding time) . It is known that
The cardiomyocyte circadian clock affects the daily variations in the heart. Studies show that the cardiomyocyte circadian clock affects myocardial contractions, the metabolism and gene expression. This clock is vital since impairment of the cardiomyocyte circadian clock might significantly alter cardiac function, cardiovascular disease pathogenesis, and treatment strategies for cardiovascular diseases (e.g., chronopharmacology) . Desynchronization between different cell types (e.g., cardiomyocytes, vascular smooth muscle cells, endothelial cells) could occur within the organs (e.g. the heart) during certain physiological or pathological conditions . The cardiomyocyte circadian clock allows the heart to predict circadian rhythm by extracellular stimuli, allowing rapid and temporally response . The cardiomyocyte circadian clock has a crucial role in mediating the daily rhythm in myocardial metabolism and affects the cardiovascular function . The cardiomyocyte circadian clock changes during illness, and this molecular mechanism might affect the etiology of cardiovascular disease .
Circadian rhythm adjusts the physiological functions of an individual on a daily basis. Daily variations of physiological parameters in the cardiovascular system maintain cardiovascular function according to the needs of different activities during the day. This information suggests that we need to know not only how, but also when to treat heart disease, and also to treat pathological changes not only symptomatically but to treat non-symptomatic but potentially harmful changes in the circadian rhythm.
Understanding the pathophysiological processes involved in the onset of myocardial infarction requires additional studies to assess the crucial elements of the circadian rhythm. In today’s personalized medicine, knowledge of the circadian rhythm (i.e., the genetic background) of an individual can be significant for treatment and should be included as an essential part of the diagnostic process.
Conflict of interest
Authors declare no conflict of interest.
Guo YF, Stein PK. Circadian rhythm in the cardiovascular system: Chronocardiology. American Heart Journal. 2003; 145:779-786. DOI: 10.1016/S0002-8703(02)94797-6
Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: Daily temporal patterns of human chronotypes. Journal of Biological Rhythms. 2003; 18:80-90. DOI: 10.1177/0748730402239679
Touitou Y, Bogdan A. Circadian and seasonal variations of physiological and biochemical determinants of acute myocardial infarction. Biological Rhythm Research. 2007; 38:169-179. DOI: 10.1080/09291010600906075
Takeda N, Maemura K. Circadian clock and vascular disease. Hypertension Research. 2010; 33:645-651. DOI: 10.1038/hr.2010.68
Suzuki S, Ishii H, Ichimiya S, Kanashiro M, Watanabe J, Uchida Y, et al. Impact of the circadian rhythm on microvascular function in patients with ST-elevation myocardial infarction. International Journal of Cardiology. 2013; 168:4948-4949. DOI: 10.1016/j.ijcard.2013.07.106
WHO. Global Status Report on Noncommunicable Diseases 2014. Geneva. p. 2015
Mendoza J. Circadian clocks: Setting time by food. Journal of Neuroendocrinology. 2007; 19:127-137. DOI: 10.1111/j.1365-2826.2006.01510.x
Chen R, Seo D-O, Bell E, von Gall C, Lee C. Strong resetting of the mammalian clock by constant light followed by constant darkness. The Journal of Neuroscience. 2008; 28:11839-11847. DOI: 10.1523/JNEUROSCI.2191-08.2008
Huang W, Ramsey KM, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. The Journal of Clinical Investigation. 2011; 121:2133-2141. DOI: 10.1172/JCI46043.rons
Mohawk JA, Green CB, Takahashi JS. Central and peripheral circadian clocks in mammals. Annual Review of Neuroscience. 2012; 35:445-462. DOI: 10.1146/annurev-neuro-060909-153128
Gibson EM, Williams WP, Kriegsfeld LJ. Aging in the circadian system: Considerations for health, disease prevention and longevity. Experimental Gerontology. 2009; 44:51-56. DOI: 10.1016/j.exger.2008.05.007
Dibner C, Schibler U. Circadian timing of metabolism in animal models and humans. Journal of Internal Medicine. 2015; 277:513-527. DOI: 10.1111/joim.12347
Dominguez-Rodriguez A, Abreu-Gonzalez P, Sanchez-Sanchez JJ, Kaski JC, Reiter RJ. Melatonin and circadian biology in human cardiovascular disease. Journal of Pineal Research. 2010; 49:14-22. DOI: 10.1111/j.1600-079X.2010.00773.x
Karaganis S. Non-ultradian cardiac rhythms: Circadian regulation of the heart. In: Vonend O, editor. Aspects of Pacemakers—Functions and Interactions in Cardiac and Non-Cardiac Indications. INTECH; 2011. pp. 67-88. DOI: 10.5772/845
Poggiogalle E, Jamshed H, Peterson CM. Circadian regulation of glucose, lipid, and energy metabolism in humans. Metabolism. 2018; 84:11-27. DOI: 10.1016/J.METABOL.2017.11.017
Eckel-Mahan K, Sassone-Corsi P. Metabolism and the circadian clock converge. Physiological Reviews. 2013; 93:107-135. DOI: 10.1152/physrev.00016.2012
Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K, Gordijn M, et al. Epidemiology of the human circadian clock. Sleep Medicine Reviews. 2007; 11:429-438. DOI: 10.1016/j.smrv.2007.07.005
Griffett K, Burris TP. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters. 2013; 23:1929-1934. DOI: 10.1016/j.bmcl.2013.02.015
Roenneberg T, Merrow M. The network of time: Understanding the molecular circadian system. Current Biology. 2003; 13:R198-R207
Konopka RJ, Benzer S. Clock mutants of Drosophila melanogaster. PNAS. 1971; 68:2112-2116
Ohkura N, Oishi K, Fukushima N, Kasamatsu M, Atsumi G-I, Ishida N, et al. Circadian CLOCK molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression. Journal of Thrombosis and Haemostasis. 2006; 4:2478-2485. DOI: 10.1111/j.1538-7836.2006.02210.x
Turek FW. Circadian clocks: Not your grandfather’s clock. Science. 2016; 354:992-993
Antypa N, Mandelli L, Nearchou FA, Vaiopoulos C, Stefanis CN, Serretti A, et al. The 3111T/C polymorphism interacts with stressful life events to influence patterns of sleep in females. Chronobiology International. 2012; 29:891-897. DOI: 10.3109/07420528.2012.699380
Kelleher FC, Rao A, Maguire A. Circadian molecular clocks and cancer. Cancer Letters. 2014; 342:9-18. DOI: 10.1016/j.canlet.2013.09.040
Langmesser S, Tallone T, Bordon A, Rusconi S, Albrecht U. Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Molecular Biology. 2008; 9:41. DOI: 10.1186/1471-2199-9-41
Ohdo S, Koyanagi S, Matsunaga N. Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock. Advanced Drug Delivery Reviews. 2010; 62:885-897. DOI: 10.1016/j.addr.2010.04.005
Partch CL, Green CB, Takahashi JS. Molecular architecture of the mammalian circadian clock. Trends in Cell Biology. 2014; 24:90-99. DOI: 10.1016/j.tcb.2013.07.002
Takeda N, Maemura K. Cardiovascular disease, chronopharmacotherapy, and the molecular clock. Advanced Drug Delivery Reviews. 2010; 62:956-966. DOI: 10.1016/j.addr.2010.04.011
Virag JAI, Lust RM. Circadian influences on myocardial infarction. Frontiers in Physiology. 2014; 5:422. DOI: 10.3389/fphys.2014.00422
Kumar J, P Challet E, Kalsbeek A. Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals. Molecular and Cellular Endocrinology. 2015; 418:74-88. DOI: 10.1016/j.mce.2015.01.024
Leu H-B, Chung C-M, Lin S-J, Chiang K-M, Yang H-C, Ho H-Y, et al. Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: A genetic association with young-onset hypertension. Hypertension Research. 2015; 38:155-162. DOI: 10.1038/hr.2014.152
Gómez-Abellán P, Madrid JA, Ordovás JM, Garaulet M. Chronobiological aspects of obesity and metabolic syndrome. Endocrinología y Nutrición. 2012; 59:50-61. DOI: 10.1016/j.endoen.2011.08.002
Gale JE, Cox HI, Qian J, Block GD, Colwell CS, Matveyenko AV. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. Journal of Biological Rhythms. 2011; 26:423-433. DOI: 10.1177/0748730411416341
Kovanen L, Saarikoski ST, Haukka J, Pirkola S, Aromaa A, Lönnqvist J, et al. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Alcohol and Alcoholism. 2010; 45:303-311. DOI: 10.1093/alcalc/agq035
Pedrazzoli M, Secolin R, Esteves LOB, Pereira DS, Koike BDV, Louzada FM, et al. Interactions of polymorphisms in different clock genes associated with circadian phenotypes in humans. Genetics and Molecular Biology. 2010; 33:627-632. DOI: 10.1590/S1415-47572010005000092
Kovanen L, Donner K, Kaunisto M, Partonen T. CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome. Hypertension Research. 2015; 38:186-192. DOI: 10.1038/hr.2014.157
Dashti HS, Smith CE, Lee Y-C, Parnell LD, Lai C-Q, Arnett DK, et al. CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiology International. 2014; 31:660-667. DOI: 10.3109/07420528.2014.886587
Young MW, Kay SA. Time zones: A comparative genetics of circadian clocks. Nature Reviews. Genetics. 2001; 2:702-715. DOI: 10.1038/35088576
Mongrain V, Cermakian N. Clock genes in health and diseases. Journal of Applied Biomedicine. 2009; 7:15-33
Cornelissen G. Metabolic syndrome, adiponectin, sleep, and the circadian system. eBioMedicine. 2018; 33:20-21. DOI: 10.1016/J.EBIOM.2018.06.013
Crnko S, Cour M, Van Laake LW, Lecour S. Vasculature on the clock: Circadian rhythm and vascular dysfunction. Vascular Pharmacology. 2018; 108:1-7. DOI: 10.1016/J.VPH.2018.05.003
WHO. Noncommunicable Diseases Progress Monitor 2017. Geneva; 2017. p. 231
Kralj V, Brkić BI. Mortalitet i morbiditet od kardiovaskularnih bolesti. Cardiologia Croatica. 2013; 8:373-378
Tengattini S, Reiter RJ, Tan D-X, Terron MP, Rodella LF, Rezzani R. Cardiovascular diseases: Protective effects of melatonin. Journal of Pineal Research. 2008; 44:16-25. DOI: 10.1111/j.1600-079X.2007.00518.x
Matura LA. Gender and circadian effects of myocardial infarctions. Clinical Nursing Research. 2010; 19:55-70. DOI: 10.1177/1054773809354371
Knutson KL. Sleep duration and cardiometabolic risk: A review of the epidemiologic evidence. Best Practice & Research. Clinical Endocrinology & Metabolism. 2010; 24:731-743. DOI: 10.1016/j.beem.2010.07.001
Morgan TM, Xiao L, Lyons P, Kassebaum B, Krumholz HM, Spertus JA. Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome. BMC Medical Genetics. 2008; 9:66. DOI: 10.1186/1471-2350-9-66
Prasai MJ, George JT, Scott EM. Molecular clocks, type 2 diabetes and cardiovascular disease. Diabetes and Vascular Disease Research. 2008; 5:89-95. DOI: 10.3132/dvdr.2008.015
Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, et al. Disruption of the CLOCK components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010; 466:627-631. DOI: 10.1038/nature09253
Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. European Heart Journal. 2007; 28:2525-2538. DOI: 10.1093/eurheartj/ehm355
Domínguez-Rodríguez A, Abreu-González P, García MJ, Sanchez J, Marrero F, de Armas-Trujillo D. Decreased nocturnal melatonin levels during acute myocardial infarction. Journal of Pineal Research. 2002; 33:248-252
Klinkenberg LJJ, van Dijk J-W, Tan FES, van Loon LJC, van Dieijen-Visser MP, Meex SJR. Circulating cardiac troponin T exhibits a diurnal rhythm. Journal of the American College of Cardiology. 2014; 63:1788-1795. DOI: 10.1016/j.jacc.2014.01.040
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. Nature Reviews. Cardiology. 2012; 9:620-633. DOI: 10.1038/nrcardio.2012.122
Saaby L, Poulsen TS, Hosbond S, Larsen TB, Pyndt Diederichsen AC, Hallas J, et al. Classification of myocardial infarction: Frequency and features of type 2 myocardial infarction. The American Journal of Medicine. 2013; 126:789-797. DOI: 10.1016/j.amjmed.2013.02.029
Alpert JS, Thygesen KA, White HD, Jaffe AS. Diagnostic and therapeutic implications of type 2 myocardial infarction: Review and commentary. The American Journal of Medicine. 2014; 127:105-108. DOI: 10.1016/j.amjmed.2013.09.031
Erdmann J, Linsel-Nitschke P, Schunkert H. Genetic causes of myocardial infarction: New insights from genome-wide association studies. Deutsches Ärzteblatt International. 2010; 107:694-699. DOI: 10.3238/arztebl.2010.0694
Kanth R, Ittaman S, Rezkalla S. Circadian patterns of ST elevation myocardial infarction in the new millennium. Clinical Medicine & Research. 2013; 11:66-72. DOI: 10.3121/cmr.2013.1120
Chong NW, Codd V, Chan D, Samani NJ. Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference. FEBS Letters. 2006; 580:4469-4472. DOI: 10.1016/j.febslet.2006.07.014
Tsimakouridze E, Alibhai F, Martino T. Therapeutic applications of circadian rhythms for the cardiovascular system. Frontiers in Pharmacology. 2015; 6:1-10. DOI: 10.3389/fphar.2015.00077
Chowta K, Prijith P, Chowta M, Prabhu M. Circadian pattern in the onset of acute myocardial infarction. Indian Academy of Clinical Medicine Journal. 2006; 7:206-210
Sheikh M, Murshad N, Majid A, Abid A, Malik S, Mallick N. Infuence of circadian variations on onset and in-hospital outcome of first acute myocardial infarction. Pakistan Heart Journal. 2010; 43:31-38
Chan C-M, Chen W-L, Kuo H-Y, Huang C-C, Shen Y-S, Choy C-S, et al. Circadian variation of acute myocardial infarction in young people. The American Journal of Emergency Medicine. 2012; 30:1461-1465. DOI: 10.1016/j.ajem.2011.11.019
López F, Lee KW, Marín F, Roldán V, Sogorb F, Caturla J, et al. Are there ethnic differences in the circadian variation in onset of acute myocardial infarction? A comparison of 3 ethnic groups in Birmingham, UK and Alicante, Spain. International Journal of Cardiology. 2005; 100:151-154. DOI: 10.1016/j.ijcard.2004.12.002
Scott EM. Circadian clocks, obesity and cardiometabolic function. Diabetes, Obesity and Metabolism. 2015; 17:84-89. DOI: 10.1111/dom.12518
Virag JAI, Dries JL, Easton PR, Friesland AM, Deantonio JH, Chintalgattu V, et al. Attenuation of myocardial injury in mice with functional deletion of the circadian rhythm gene mPer2. American Journal of Physiology-Heart and Circulatory Physiology. 2010; 198:H1088-H1095
Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the clock gene, obesity and the metabolic syndrome in man. International Journal of Obesity. 2008; 32:658-662. DOI: 10.1038/sj.ijo.0803778
Corella D, Asensio EM, Coltell O, Sorlí JV, Estruch R, Martínez-González MÁ, et al. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: Dietary modulation in the PREDIMED randomized trial. Cardiovascular Diabetology. 2016; 15:4. DOI: 10.1186/s12933-015-0327-8
Škrlec I. Varijabilnost gena cirkadijalnog ritma u osoba s infarktom miokarda [thesis]. Osijek: Faculty of Medicine; 2018
Škrlec I, Milić J, Heffer M, Peterlin B, Wagner J. Genetic variations in circadian rhythm genes and susceptibility for myocardial infarction. Genetics and Molecular Biology. 2018; 41:403-409. DOI: 10.1590/1678-4685-gmb-2017-0147
Gómez-Abellán P, Hernández-Morante JJ, Luján JA, Madrid JA, Garaulet M. Clock genes are implicated in the human metabolic syndrome. International Journal of Obesity. 2008; 32:121-128. DOI: 10.1038/sj.ijo.0803689
Paneni F, Beckman JA, Creager MA, Cosentino F. Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I. European Heart Journal. 2013; 34:2436-2443. DOI: 10.1093/eurheartj/eht149
Martín-Timón I, Sevillano-Collantes C, Segura-Galindo A, Del Cañizo-Gómez FJ. Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? World Journal of Diabetes. 2014; 5:444-470. DOI: 10.4239/wjd.v5.i4.444
Suárez-Barrientos A, López-Romero P, Vivas D, Castro-Ferreira F, Núñez-Gil I, Franco E, et al. Circadian variations of infarct size in acute myocardial infarction. Heart. 2011; 97:970-976. DOI: 10.1136/hrt.2010.212621
Takeda N, Maemura K. The role of clock genes and circadian rhythm in the development of cardiovascular diseases. Cellular and Molecular Life Sciences. 2015; 72:3225-3234. DOI: 10.1007/s00018-015-1923-1
Martino TA, Sole MJ. Molecular time: An often overlooked dimension to cardiovascular disease. Circulation Research. 2009; 105:1047-1061. DOI: 10.1161/CIRCRESAHA.109.206201
Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013; 8:e71493. DOI: 10.1371/journal.pone.0071493
Bray MS, Shaw CA, Moore MWS, Garcia RAP, Zanquetta MM, Durgan DJ, et al. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. American Journal of Physiology-Heart and Circulatory Physiology. 2008; 294:H1036-H1047. DOI: 10.1152/ajpheart.01291.2007
Durgan DJ, Young ME. The cardiomyocyte circadian clock: Emerging roles in health and disease. Circulation Research. 2010; 106:647-658. DOI: 10.1161/CIRCRESAHA.109.209957
Chatham JC, Young ME. Regulation of myocardial metabolism by the cardiomyocyte circadian clock. Journal of Molecular and Cellular Cardiology. 2013; 55:139-146. DOI: 10.1016/J.YJMCC.2012.06.016